CN1712026A - Compound Chinese medicinal preparation containing Astragalus mongholicus active component - Google Patents
Compound Chinese medicinal preparation containing Astragalus mongholicus active component Download PDFInfo
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- CN1712026A CN1712026A CN 200410025558 CN200410025558A CN1712026A CN 1712026 A CN1712026 A CN 1712026A CN 200410025558 CN200410025558 CN 200410025558 CN 200410025558 A CN200410025558 A CN 200410025558A CN 1712026 A CN1712026 A CN 1712026A
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Abstract
A compound Chinese medicine contains proportionally one or more of the active components extracted from astragalus root, ginseng, shortscape fleabane herb, acanthopanax bark and notoginseng, and the pharmacologically acceptable carrier or auxiliary.
Description
Technical field
The present invention relates to a kind of Chinese traditional compound medicine, especially relate to a kind of Radix Astragali active component that contains, especially relate to a kind of Radix Astragali active component that contains, and with the active component of other kinds of traditional Chinese medicines, by a certain percentage the Chinese traditional compound medicine that forms of compatible combination.
Background technology
As time goes on the progress of society, the aging trend of Chinese population is also more and more obvious, and people are also more and more higher to the requirement of good health and a long life, and the demand of medicine also constantly increases thereupon, and wherein the demand of Chinese medicine and Chinese medicine preparation is the trend of rising appreciably.On the other hand, cardiovascular and cerebrovascular disease has become the first human killer, and cancerous protuberance is one of main threat of human life, and development medicine to the ill is medical worker's a vital task.Yet, present Chinese medicine preparation adopts Chinese crude drug directly to extract preparation mostly, component content by inventory control pharmaceutical preparation, but since the place of production difference of raw material, the not equal reason of collecting season difference, resting period length, make that the actual active constituent content in each batch pharmaceutical preparation is also inconsistent, so can not guarantee the stability of drug quality, the safety of pharmaceutical preparation, effectiveness are difficult to obtain desirable control, even improper malpractice occurs.
Summary of the invention
It is restive to the invention solves in the existing in prior technology Chinese medicine preparation active constituent content, the technical problem that safety, effectiveness and stability are not good enough etc., but provide active constituent content in a kind of better controlled medicament, safety is higher, a kind of Chinese traditional compound medicine that is used to prevent and treat human senilism, cancerous protuberance, cardio-cerebrovascular diseases that effect is preferable.
The present invention has solved also that existing in prior technology Chinese medicine preparation compatibility is not good enough, and indication is narrow partially, and the technical problem that takes effect and wait more slowly provides a kind of compatibility better, a kind of Chinese traditional compound medicine of indication broad and quick result.
Above-mentioned technical purpose of the present invention solves by the following technical programs: a kind of Chinese traditional compound medicine that contains Radix Astragali active component, it is characterized in that being grouped into (weight ratio): Radix Astragali active component 1-8 part by following one-tenth, be equipped with the Radix Ginseng active component, the Herba Erigerontis active component, the Radix Et Caulis Acanthopanacis Senticosi active component, in the pseudo-ginseng activity composition one or more, proportion compatibility is Radix Ginseng active component 0.2-4 part, Herba Erigerontis active component 0.2-4 part, Radix Et Caulis Acanthopanacis Senticosi active component 3-10 part, pseudo-ginseng activity composition 3-10 part, mix with pharmaceutically acceptable pharmaceutical carrier or adjuvant, make Chinese traditional compound medicine.The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali, is tonic commonly used, and sweet in the mouth, warm in nature is returned lung, spleen channel.Have the raising immunologic function, prolong cell survival; Strengthen hemopoietic function, reduce blood viscosity; The protection heart body suppresses tumor, strengthens the effect of renal function, is a kind of application Chinese crude drug very widely.Radix Notoginseng is the dry root of panax araliaceae plant, having the effect of loose silt hemostasis, subduing swelling and relieving pain, and coronary heart disease, angina pectoris are had significant curative effect.Herba Erigerontis is the herb of feverfew, has expelling cold and relieving exterior syndrome, pain relieving, easypro effect through invigorating blood circulation, and can be used for treating symptom such as hypertension, cerebral hemorrhage, cerebral embolism.Radix Et Caulis Acanthopanacis Senticosi is the dry root and rhizome or the stem of Araliaceae Radix Et Caulis Acanthopanacis Senticosi, has the metabolic function of the body of adjusting, improve the nonspecific resistance of body, improve the adaptability and the toleration of body, lower of the effect of the multiple virulence factor in inside and outside body damage to the destructive stimulus factor.Radix Ginseng is the dry root of Araliaceae Radix Ginseng, has that strongly invigorating primordial QI, multiple arteries and veins take off admittedly, an invigorating the spleen to benefit the lung, the effect of promoting the production of body fluid, calming the nerves.This Chinese medicine preparation is based on Radix Astragali active component, be equipped with the active component of wherein one or both or three kinds of medicines again, the method that reaches is by a certain percentage made Chinese traditional compound medicine, have transfer invigorating primordial QI, uphold the good and suppress the bad, effects such as activating blood circulation to dissipate blood stasis, regulating QI to relieve pain, can be used for preventing and treating diseases such as senilism, cancerous protuberance, cardiovascular and cerebrovascular vessel.The rare Chinese medicine that the selected a few flavor Chinese medicines of this Chinese traditional compound medicine all are China, the mutual compatibility between them both remedied the not enough and narrow partially defective of indication of single pharmaceutical treatment disease effect, coordinated again medicine between pharmacological action, be to bring out the best in each other.Along with development of modern science and technology, people have successfully isolated corresponding effective active composition---saponin, polysaccharide or its mixture and flavone from the Radix Astragali, Radix Ginseng, Herba Erigerontis, Radix Et Caulis Acanthopanacis Senticosi, Radix Notoginseng, and be applied to clinically, obtained better therapeutic effect.Chinese medicine preparation of the present invention is the not only clear and definite active drug composition that is contained, give the proportion compatibility of each active component, the traditional characteristics that had both kept Chinese medicine, merged the modern pharmaceutical technology again, be comparatively advanced at present drug preparation technique, effectively solved controllability, safety, the effectiveness of pharmaceutical preparation.
Chinese traditional compound medicine of the present invention comprises dosage forms such as injection, oral liquid, tablet, capsule, drop pill and granule.Used pharmaceutical carrier comprises isotonic agent, buffer agent, proppant (excipient), disintegrating agent and water for injection etc.Used isotonic agent can be sodium chloride, glucose, fructose, xylitol, sorbitol; Used buffer agent can be sodium sulfite, sodium sulfite, sodium pyrosulfite, sodium carbonate, sodium bicarbonate, sodium hydroxide, lactic acid, hydrochloric acid, acetic acid etc.Used adjuvant comprises disintegrating agent: carboxymethyl starch sodium, starch, microcrystalline Cellulose, sodium carboxymethyl cellulose; Antiseptic: sorbic acid, benzoic acid, propanoic acid; Correctives: Mel, simple syrup, glycyrrhizin, stevioside; Fluidizer: micropowder silica gel, magnesium stearate, Pulvis Talci; Filler: starch, dextrin, Icing Sugar, lactose, calcium hydrogen phosphate.
As preferably, the optimization proportioning of described Chinese traditional compound medicine is (weight ratio): Radix Astragali active component 3-6 part, be equipped with in Radix Ginseng active component, Herba Erigerontis active component, Radix Et Caulis Acanthopanacis Senticosi active component, the pseudo-ginseng activity composition one or more, proportion compatibility is Radix Ginseng active component 0.5-2 part, Herba Erigerontis active component 0.5-2 part, Radix Et Caulis Acanthopanacis Senticosi active component 4-8 part, pseudo-ginseng activity composition 4-8 part, mix with pharmaceutically acceptable pharmaceutical carrier or adjuvant, make Chinese traditional compound medicine.Each active component during compatibility, can obtain better effect according to the above ratio.
As preferably, the described Chinese traditional compound medicine that contains Radix Astragali active component, it is characterized in that being grouped into (weight ratio): 6 parts of Radix Astragali active component by following one-tenth, be equipped with 1 part of Herba Erigerontis active component, 6 parts of Radix Et Caulis Acanthopanacis Senticosi active component, 4 parts of pseudo-ginseng activity compositions, mix with pharmaceutically acceptable pharmaceutical carrier or adjuvant, make Chinese traditional compound medicine.
As preferably, the Radix Astragali active component in the described Chinese traditional compound medicine is meant Radix Astragali effective active composition---contain Radix Astragali saponin more than 50% or astragalus polysaccharides more than 50%; The Radix Ginseng active component comprises the effective active composition that extracts in Radix Ginseng and the Stem and leaf of Radix Ginseng---contains more than the ginsenoside 20 %; The Herba Erigerontis active component is meant Herba Erigerontis effective active composition---contain breviscapine more than 95%; The Radix Et Caulis Acanthopanacis Senticosi active component is meant Radix Et Caulis Acanthopanacis Senticosi effective active composition---contain Radix Et Caulis Acanthopanacis Senticosi glucoside 50% or Radix Et Caulis Acanthopanacis Senticosi polysaccharide more than 50%; The pseudo-ginseng activity composition is meant Radix Notoginseng effective active composition---contain in the Radix Notoginseng total saponins more than 60%.Use the effective active composition that is contained in each Chinese medicine, can better control the content of each composition in the medicament, further strengthened stability of formulation, safety and effectiveness.
Therefore, the present invention has characteristics such as active constituent content is clear and definite, and safety is higher, and effect is preferable, is that a kind of compatibility is better, the Chinese traditional compound medicine of indication broad.
The specific embodiment
Below by specific embodiment, and in conjunction with the accompanying drawings, technical scheme of the present invention is described in further detail.
Embodiment 1: preparation contains the liquid drugs injection of astragalus polysaccharides and breviscapine, carry out according to the following steps: take by weighing astragalus polysaccharides 120g, breviscapine 8g, add water for injection to 4000ml, warmly make moltenly, add activated carbon decolorizing, remove pyrogen, with sand rod elimination active carbon, add water for injection to 5000ml, regulating pH value with the pH regulator agent is 6.0～7.8.Detect its content, when qualified, through 0.22 μ m microporous filter membrane fine straining, fill was sterilized 30 minutes in the ampoule of cleaning, and cooled off laggard portable lighter inspection, again through after the assay was approved, obtained 1000 of liquid drugs injection finished products.
Embodiment 2: preparation contains the liquid drugs injection of Radix Astragali saponin, Radix Et Caulis Acanthopanacis Senticosi glucoside and Radix Notoginseng total arasaponins, get Radix Astragali saponin 50g, Radix Et Caulis Acanthopanacis Senticosi glucoside 115g, Radix Notoginseng total arasaponins 125g, be dissolved in the 4000ml water for injection, stirring makes dissolving,, add the active carbon room temperature and stirred 30 minutes, remove pyrogen, with sand rod elimination active carbon, add the injection water to 5000ml, regulating pH value is 5.0～7.5.Intermediate is measured, and when qualified, through 0.22 μ m microporous filter membrane fine straining, fill was sterilized 30 minutes in the ampoule of cleaning, and cools off laggard portable lighter inspection, again through after the assay was approved, obtains 1000 of liquid drugs injection finished products.
Embodiment 3: the freeze-dried powder that preparation contains astragalus polysaccharides, Radix Astragali saponin and the breviscapine of mannitol, carry out: take by weighing astragalus polysaccharides 130g, Radix Astragali saponin 60g according to the following steps, breviscapine 8g, add water for injection to 1600ml, add mannitol 50g, warm make molten, stir, add activated carbon decolorizing, remove pyrogen, with sand rod elimination active carbon, add water for injection to 2000ml, regulating pH value with the pH regulator agent is 6.0～7.8.With 0.22 μ m filtering with microporous membrane, fill is put the freeze dryer lyophilization in the glass tube vial of cleaning, and vacuum falls to covering, and obtains 1000 bottles of freeze-dried powder finished products.
Embodiment 4: preparation contains the freeze-dried powder of astragalus polysaccharides, Radix Astragali saponin and Radix Et Caulis Acanthopanacis Senticosi glucoside, get astragalus polysaccharides 150g, astragaloside 50g, Radix Et Caulis Acanthopanacis Senticosi glucoside 150g, be dissolved in the 1600ml water for injection, stirring makes dissolving, adds mannitol 80g, stirs, adding the active carbon room temperature stirred 30 minutes, be filtered to clear and brightly, add the injection water to 2000ml, regulating pH is 5.0～7.5, intermediate is measured, with being sub-packed in the glass tube vial after the 0.22 μ m microporous filter membrane aseptic filtration, put the freezer dryer lyophilizing, vacuum fall to covering 1000 bottles of freeze-dried powders.
Embodiment 5: preparation contains the aseptic powder injection of Radix Astragali saponin, breviscapine and Radix Notoginseng total arasaponins, carry out according to the following steps: take by weighing Radix Astragali saponin 100g, breviscapine 8g, Radix Notoginseng total arasaponins 150g, add water for injection to 1600ml, warmly make moltenly, stir, add activated carbon decolorizing, remove pyrogen, with sand rod elimination active carbon, regulating pH value with the pH regulator agent is 6.0～7.8, adds water for injection to 2000ml.With 0.22 μ m filtering with microporous membrane, medicinal liquid is obtained sterilized powder by spray drying, aseptic subpackaged in the glass tube vial of cleaning, lid is rolled in tamponade, obtains 1000 bottles of aseptic powder injection finished products.
Embodiment 6: preparation contains the aseptic powder injection of Radix Astragali saponin, Radix Notoginseng total arasaponins and Radix Et Caulis Acanthopanacis Senticosi glucoside, get Radix Astragali saponin 100g, Radix Notoginseng total arasaponins 60g, Radix Et Caulis Acanthopanacis Senticosi glucoside 100g, be dissolved in the 1400ml water for injection, stirring makes dissolving, adds the active carbon room temperature and stirs 30 minutes, is filtered to clear and bright, add the injection water to 2000ml, regulating pH is 5.0～7.8, and intermediate is measured, with 0.22 μ m microporous filter membrane aseptic filtration, put lyophilizing in the deep bid, crushing screening is sub-packed in the glass tube vial, tamponade roll cover 1000 bottles of aseptic powder injections.
Embodiment 7: preparation contains Radix Astragali saponin, the transfusion of astragalus polysaccharides and Radix Notoginseng total arasaponins, carry out according to the following steps: take by weighing astragalus polysaccharides 140g, Radix Astragali saponin 40g, Radix Notoginseng total arasaponins 180g adds water for injection to 40000ml, warm make molten, stir, after the dissolving, add activated carbon decolorizing, remove pyrogen, with sand rod elimination active carbon, add the injection water to 50000ml, regulating pH value with the pH regulator agent is 6.0～7.8, and fill is in infusion bottle of cleaning or transfusion bag, 115 ℃ of flowing steam sterilizations 15 minutes, cool off the inspection of laggard portable lighter, again through after the assay was approved, 1000 bottles of finished products obtain infusing.
Embodiment 8: preparation contains the transfusion of Radix Astragali saponin and Radix Et Caulis Acanthopanacis Senticosi glucoside, get Radix Astragali saponin 100g, Radix Et Caulis Acanthopanacis Senticosi glucoside 100g, be dissolved in the 80000ml water for injection, stirring makes dissolving, add the active carbon room temperature and stirred 30 minutes, be filtered to clear and brightly, add the injection water to 100000ml, regulating pH is 5.0～7.8, intermediate is measured, and with 0.22 μ m microporous filter membrane aseptic filtration, fill is in the 100ml infusion bottle, 115 ℃ of flowing steam sterilizations 15 minutes, cool off laggard portable lighter inspection,, must infuse 1000 bottles again through after the assay was approved.
Embodiment 9: the oral liquid that preparation contains astragalus polysaccharides, ginsenoside and Radix Notoginseng total arasaponins, carry out according to the following steps: take by weighing astragalus polysaccharides 200g, ginsenoside 20g, Radix Notoginseng total arasaponins 150g adds water for injection 8000ml and makes dissolving, stirs, and leaves standstill.Add 0.1% sorbic acid, adjust total amount, stir evenly, filter to 10000ml, fill, sterilization promptly gets 1000 bottles of oral liquid finished products.
Embodiment 10: the capsule that preparation contains Radix Astragali saponin, ginsenoside and Radix Notoginseng total arasaponins, carry out: take by weighing Radix Astragali saponin 100g, ginsenoside 30g, Radix Notoginseng total arasaponins 150g according to the following steps, starch 300g, mix homogeneously sieves, 60 ℃ of oven dry, encapsulated, promptly get 1000 of capsule finished products.
Embodiment 11: preparation contains the granule of astragalus polysaccharides, Radix Et Caulis Acanthopanacis Senticosi polysaccharide and Radix Notoginseng total arasaponins, carry out according to the following steps: take by weighing astragalus polysaccharides 150g, Radix Et Caulis Acanthopanacis Senticosi polysaccharide 150g, Radix Notoginseng total arasaponins 150g, the mixture of sucrose and dextrin (3: 1) 300g, mixing, sieve, make granule in right amount, 60 ℃ of dryings with ethanol, pack promptly gets 1000 bags of granules.
Embodiment 12: the tablet that preparation contains Radix Astragali saponin, ginsenoside and Radix Notoginseng total arasaponins, carry out: take by weighing Radix Astragali saponin 150g, breviscapine 20g according to the following steps; Radix Notoginseng total arasaponins 150g, lactose 100g, mixing; make soft material with 10% starch slurry; the granulation of sieving, 60 ℃ of dryings, granulate; add 1% magnesium stearate, an amount of sodium carboxymethyl cellulose; with granule mixing, tabletting, get product 1000.
Embodiment 13: preparation contains the drop pill of astragalus polysaccharides, Radix Notoginseng total arasaponins, carry out according to the following steps: take by weighing astragalus polysaccharides 250g, Radix Notoginseng total arasaponins 200g, Macrogol 4000 1000g after the adding fusion, following insulation is 3.3mm with internal diameter about 80 ℃, external diameter is the 5.1mm dropper, drip speed with 60～70 droplets/minute and splash in the methyl-silicone oil, collect drop pill, get product 100000.
Claims (9)
1, a kind of Chinese traditional compound medicine that contains Radix Astragali active component, it is characterized in that being grouped into (weight ratio): Radix Astragali active component 1-8 part by following one-tenth, be equipped with in Radix Ginseng active component, Herba Erigerontis active component, Radix Et Caulis Acanthopanacis Senticosi active component, the pseudo-ginseng activity composition one or more, proportion compatibility is Radix Ginseng active component 0.2-4 part, Herba Erigerontis active component 0.2-4 part, Radix Et Caulis Acanthopanacis Senticosi active component 3-10 part, pseudo-ginseng activity composition 3-10 part, mix with pharmaceutically acceptable pharmaceutical carrier or adjuvant, make Chinese traditional compound medicine.
2, the Chinese traditional compound medicine that contains Radix Astragali active component according to claim 1, it is characterized in that being grouped into (weight ratio): Radix Astragali active component 3-6 part by following one-tenth, be equipped with in Radix Ginseng active component, Herba Erigerontis active component, Radix Et Caulis Acanthopanacis Senticosi active component, the pseudo-ginseng activity composition one or more, proportion compatibility is Radix Ginseng active component 0.5-2 part, Herba Erigerontis active component 0.5-2 part, Radix Et Caulis Acanthopanacis Senticosi active component 4-8 part, pseudo-ginseng activity composition 4-8 part, mix with pharmaceutically acceptable pharmaceutical carrier or adjuvant, make Chinese traditional compound medicine.
3, the Chinese traditional compound medicine that contains Radix Astragali active component according to claim 1 and 2, it is characterized in that being grouped into (weight ratio): 6 parts of Radix Astragali active component by following one-tenth, be equipped with 1 part of Herba Erigerontis active component, 6 parts of Radix Et Caulis Acanthopanacis Senticosi active component, 4 parts of pseudo-ginseng activity compositions, mix with pharmaceutically acceptable pharmaceutical carrier or adjuvant, make Chinese traditional compound medicine.
4, the Chinese traditional compound medicine that contains Radix Astragali active component according to claim 1 and 2 is characterized in that described Radix Astragali active component, is meant Radix Astragali effective active composition---contain Radix Astragali saponin more than 50% or astragalus polysaccharides more than 50%.
5, the Chinese traditional compound medicine that contains Radix Astragali active component according to claim 3 is characterized in that described Radix Astragali active component, is meant Radix Astragali effective active composition---contain Radix Astragali saponin more than 50% or astragalus polysaccharides more than 50%.
6, the Chinese traditional compound medicine that contains Radix Astragali active component according to claim 1 and 2 is characterized in that described Radix Ginseng active component, comprises the effective active composition that extracts in Radix Ginseng and the Stem and leaf of Radix Ginseng---contain more than the ginsenoside 20 %.
7, the Chinese traditional compound medicine that contains Radix Astragali active component according to claim 1 and 2 is characterized in that described Herba Erigerontis active component, is meant Herba Erigerontis effective active composition---contain breviscapine more than 95%.
8, claim 1 or the 2 described Chinese traditional compound medicines that contain Radix Astragali active component is characterized in that described Radix Et Caulis Acanthopanacis Senticosi active component, are meant Radix Et Caulis Acanthopanacis Senticosi effective active composition---contain Radix Et Caulis Acanthopanacis Senticosi glucoside 50% or Radix Et Caulis Acanthopanacis Senticosi polysaccharide more than 50%.
9, the Chinese traditional compound medicine that contains Radix Astragali active component according to claim 1 and 2 is characterized in that described pseudo-ginseng activity composition, is meant Radix Notoginseng effective active composition---contain in the Radix Notoginseng total saponins more than 60%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410025558 CN1712026A (en) | 2004-06-22 | 2004-06-22 | Compound Chinese medicinal preparation containing Astragalus mongholicus active component |
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| CN 200410025558 CN1712026A (en) | 2004-06-22 | 2004-06-22 | Compound Chinese medicinal preparation containing Astragalus mongholicus active component |
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| CN 200410025558 Pending CN1712026A (en) | 2004-06-22 | 2004-06-22 | Compound Chinese medicinal preparation containing Astragalus mongholicus active component |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994345B (en) * | 2006-01-06 | 2010-05-12 | 程高楼 | Compound Chinese medicinal formulation for treating cardiovascular and cerebrovascular disease |
| CN102813790A (en) * | 2012-07-28 | 2012-12-12 | 张茂根 | Traditional Chinese medicine for treating yin-yang deficiency type chronic heart failure |
| CN114344435A (en) * | 2022-01-11 | 2022-04-15 | 中优尚品(广州)生物科技有限公司 | Thrombolytic oral bacteriostatic spray and preparation method thereof |
-
2004
- 2004-06-22 CN CN 200410025558 patent/CN1712026A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994345B (en) * | 2006-01-06 | 2010-05-12 | 程高楼 | Compound Chinese medicinal formulation for treating cardiovascular and cerebrovascular disease |
| CN102813790A (en) * | 2012-07-28 | 2012-12-12 | 张茂根 | Traditional Chinese medicine for treating yin-yang deficiency type chronic heart failure |
| CN114344435A (en) * | 2022-01-11 | 2022-04-15 | 中优尚品(广州)生物科技有限公司 | Thrombolytic oral bacteriostatic spray and preparation method thereof |
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