CN1709430A - Medicinal bock greenbrier rhizome micro pill and its preparing method - Google Patents
Medicinal bock greenbrier rhizome micro pill and its preparing method Download PDFInfo
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- CN1709430A CN1709430A CN 200510080293 CN200510080293A CN1709430A CN 1709430 A CN1709430 A CN 1709430A CN 200510080293 CN200510080293 CN 200510080293 CN 200510080293 A CN200510080293 A CN 200510080293A CN 1709430 A CN1709430 A CN 1709430A
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- rhizoma smilacis
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- smilacis bockii
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Abstract
The present invention discloses a medicine micropill and its preparation method. Said medicine micropill contains dried Bock's greenbrier root extract, microcrystalline cellulose and cross-linked polyvidone. Its quality is stable and its therapeutic effect is reliable.
Description
Invention field
The present invention relates to a kind of medicament pellet and preparation method thereof, particularly a kind of Buddha's warrior attendant rattan Pill and its preparation method.
Background technology
The Rhizoma Smilacis Bockii medical material is the dry rhizome of liliaceous plant Rhizoma Smilacis Chinensis (Smilax Ching 1.), and main product has expelling wind and removing dampness in Hubei, Hunan and other places, and the function of detoxifcation dissipating blood stasis is used for muscles and bones aching, dribbling urination, profuse leukorrhea, furuncle carbuncle.
'Jingangteng ' has syrup, capsule and tablet, and function is a heat-clearing and toxic substances removing, and dispersing swelling and dissipating binds is used for the multiple inflammation of adnexitis and inflammatory masses of ovarian appendages and gynecological.There are the problems such as inconvenience that dissolution velocity is slow, bioavailability is low, take and carry in existing preparation, and has seriously fettered applying of 'Jingangteng '.Develop a kind of determined curative effect, cheap, the 'Jingangteng ' that is fit to China's national situation, carries taking convenience, have no side effect, have important theoretical meaning and value for clinical application, and will produce good economic benefit and social benefit.
Summary of the invention
One object of the present invention is to disclose a kind of Bock greenbrier rhizome micro pill; Another object of the present invention is to disclose a kind of preparation method of Bock greenbrier rhizome micro pill.
The raw material of medicament pellet of the present invention is formed and proportioning following (by weight):
Rhizoma Smilacis Bockii dry extract 45-150 weight portion, add microcrystalline Cellulose 50-90 weight portion, polyvinylpolypyrrolidone 5-15 weight portion
It is (by weight) that the raw material of medicament pellet of the present invention is formed optimum ratio:
Rhizoma Smilacis Bockii dry extract 120 weight portions, add microcrystalline Cellulose 70 weight portions, polyvinylpolypyrrolidone 10 weight portions
It is (by weight) that the raw material of medicament pellet of the present invention is formed optimum ratio:
Rhizoma Smilacis Bockii dry extract 140 weight portions, add microcrystalline Cellulose 55 weight portions, polyvinylpolypyrrolidone 13 weight portions
It is (by weight) that the raw material of medicament pellet of the present invention is formed optimum ratio:
Rhizoma Smilacis Bockii dry extract 50 weight portions, add microcrystalline Cellulose 85 weight portions, polyvinylpolypyrrolidone 6 weight portions
The Rhizoma Smilacis Bockii dry extract can be conventional solvent and conventional method preparation.The present invention also provides the method for being prepared as follows:
Rhizoma Smilacis Bockii is decocted with water 1-3 time, and each 1-3 hour, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, made that to contain amount of alcohol in the solution be 20~70%, left standstill filtration, filtrate recycling ethanol 12-36 hour; Clear paste is evaporated to relative density 1.15~1.25 (60 ℃ of heat are surveyed), is spray dried to dry extract; Or being evaporated to relative density 1.35~1.38 (60 ℃ of heat are surveyed), vacuum drying becomes dry extract.
The preparation method of said medicine micropill:
The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone, mix homogeneously; Add water and stir the system soft material in right amount, soft material is with the granulation of sieving of 10-20 mesh sieve, and wet granular is round as a ball, makes micropill; Or a wet micropill 50-80 ℃ drying, make pellet preparations, promptly.
Above-mentioned wet granular micropill can be made other pills: honeyed pill, water-honeyed pill, the watered pill, paste pill, wax pill, concentrated pill etc.
The preparation technology of water-honeyed pill is:
The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone, mix homogeneously is made micropill; Add an amount of general ball of water with refined honey 30~40 weight portions, drying is made water-honeyed pill, promptly.
The preparation technology of the watered pill is:
The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone, mix homogeneously is made micropill; Use water pill, drying is made the watered pill, promptly.
The preparation technology of paste pill is:
The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone, mix homogeneously is made micropill; Adding adds the rice paste that water is made with Semen oryzae sativae powder 7-10 weight portion, pill, and drying is made 200 weight portion paste pills, promptly approximately.
Rhizoma Smilacis Bockii is made Bock greenbrier rhizome micro pill, can make that medicine is fast molten to loose, improve bioavailability, also have taking convenience, easy to carry, be easy to advantages such as transportation and preservation, steady quality, determined curative effect.
Following experimental example is used to further specify the present invention:
Experimental example 1: prescription design
This product dry extract is to carry the after drying gained through water, character according to medicated powder, selecting microcrystalline Cellulose is diluent, and the microcrystalline Cellulose compressibility is better, and quickens the pill disintegrate, selecting hyprolose (the low replacement), polyvinylpolypyrrolidone, carboxymethyl starch sodium is disintegrating agent, selecting water is binding agent, counts ten prescriptions, sees Table 1, with outward appearance, one-tenth ball, dissolve scattered time limit is the examination index, the results are shown in Table 2.
Ten prescriptions of table 1 design
Method for making: dry extract and adjuvant are crossed 100 mesh sieves respectively, take by weighing dry extract and required adjuvant by recipe quantity, mix homogeneously adds water and stirs the system soft material in right amount, and soft material is with the granulation of sieving of 12-20 mesh sieve, and wet granular is round as a ball, and 50-80 ℃ of drying made the 200g micropill.
Dissolve scattered time limit: getting this product by the inspection of an appendix dissolve scattered time limit of Chinese Pharmacopoeia version in 2000 algoscopy, is medium with water, should be in 2 hours moltenly looses and passes through screen cloth.
The investigation result of ten prescriptions of table 2
Conclusion: investigate results according to ten prescriptions, ten prescriptions all meet the requirements, and it is eight ideal wherein to write out a prescription, and dissolve scattered time limit is the shortest, and outward appearance is bright and clean attractive in appearance.So main adjuvant is selected microcrystalline Cellulose 70g, polyvinylpolypyrrolidone 10g in the prescription.
Experimental example 2: the contrast experiment of this Bock greenbrier rhizome micro pill and Rhizoma Smilacis Bockii capsule, sheet: compare during the disintegrate of the dissolve scattered time limit of this Bock greenbrier rhizome micro pill and Rhizoma Smilacis Bockii capsule, sheet, the results are shown in Table 3.
Comparative result disintegration of dissolve scattered time limit of this Bock greenbrier rhizome micro pill of table 3 and Rhizoma Smilacis Bockii capsule, sheet
This Bock greenbrier rhizome micro pill | The Rhizoma Smilacis Bockii capsule | The Rhizoma Smilacis Bockii sheet | |
Dissolve scattered time limit disintegration | About 7 minutes | About 15 minutes | About 40 minutes |
Conclusion: as can be known from the above table, the dissolve scattered time limit of this Bock greenbrier rhizome micro pill is obviously short than the disintegration of Rhizoma Smilacis Bockii capsule, sheet, and the Bock greenbrier rhizome micro pill of this research can fast instantly loose the bioavailability height.
Experimental example 3: the preparation method of this Bock greenbrier rhizome micro pill and traditional pill preparation method contrast experiment:
The normal preparation method that adopts of medicine pill is to rub ball method and agitation procedure with the hands, adopts agitation procedure to prepare the Rhizoma Smilacis Bockii ball, will compare with the Bock greenbrier rhizome micro pill of this research, the results are shown in Table 4.
The Bock greenbrier rhizome micro pill that table 4 agitation procedure prepares Rhizoma Smilacis Bockii ball and this research compares
Agitation procedure prepares the Rhizoma Smilacis Bockii ball | The Bock greenbrier rhizome micro pill of this research | |
Dissolve scattered time limit | About 7 minutes | About 30 minutes |
The result: as can be known from the above table, it is short that the Bock greenbrier rhizome micro pill dissolve scattered time limit of this research obviously prepares Rhizoma Smilacis Bockii ball dissolve scattered time limit than agitation procedure, can fast instantly loose the bioavailability height.
Embodiment 1:Bock greenbrier rhizome micro pill
1500g decocts with water secondary with Rhizoma Smilacis Bockii, and each 2 hours, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, makes that to contain amount of alcohol in the solution be 20~70%, leaves standstill filtration, filtrate recycling ethanol 24 hours.Clear paste is evaporated to relative density 1.15~1.25 (60 ℃ of heat are surveyed), is spray dried to dry extract 120g; The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose 70g, polyvinylpolypyrrolidone 10g, mix homogeneously.Add water and stir the system soft material in right amount, soft material is with the granulation of sieving of 14 mesh sieves, and wet granular is round as a ball, and 60 ℃ of dryings are made the 200g micropill, promptly approximately.
Embodiment 2:Bock greenbrier rhizome micro pill
1500g decocts with water secondary with Rhizoma Smilacis Bockii, and each 2 hours, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, makes that to contain amount of alcohol in the solution be 20~70%, leaves standstill filtration, filtrate recycling ethanol 24 hours.Clear paste is evaporated to relative density 1.35~1.38 (60 ℃ of heat are surveyed), and vacuum drying becomes dry extract 140g.The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose 55g, polyvinylpolypyrrolidone 13g, mix homogeneously.Add water and stir the system soft material in right amount, soft material is with the granulation of sieving of 14 mesh sieves, and wet granular is round as a ball, and 60 ℃ of dryings are made the 200g micropill, promptly approximately.
Embodiment 3:Bock greenbrier rhizome micro pill
1500g decocts with water secondary with Rhizoma Smilacis Bockii, and each 2 hours, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, makes that to contain amount of alcohol in the solution be 20~70%, leaves standstill filtration, filtrate recycling ethanol 24 hours.Clear paste is evaporated to relative density 1.15~1.25 (60 ℃ of heat are surveyed), is spray dried to dry extract 50g; The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose 85g, polyvinylpolypyrrolidone 6g, mix homogeneously.Add water and stir the system soft material in right amount, soft material is with the granulation of sieving of 14 mesh sieves, and wet granular is round as a ball, and 60 ℃ of dryings are made the 200g micropill, promptly approximately.
Embodiment 4:Rhizoma Smilacis Bockii water-honeyed pill preparation
1500g decocts with water secondary with Rhizoma Smilacis Bockii, and each 2 hours, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, makes that to contain amount of alcohol in the solution be 20~70%, leaves standstill filtration, filtrate recycling ethanol 24 hours.Clear paste is evaporated to relative density 1.15~1.25 (60 ℃ of heat are surveyed), is spray dried to dry extract 100g; The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose 70g, polyvinylpolypyrrolidone 10g, mix homogeneously is made micropill.Add refined honey 30-40g and add the solution that water is made into and stir the system soft material in right amount, soft material is with the granulation of sieving of 14 mesh sieves, and wet granular is round as a ball, and 60 ℃ of dryings are made the 200g water-honeyed pill approximately.
Embodiment 5:Rhizoma Smilacis Bockii watered pill preparation
1500g decocts with water secondary with Rhizoma Smilacis Bockii, and each 2 hours, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, makes that to contain amount of alcohol in the solution be 20~70%, leaves standstill filtration, filtrate recycling ethanol 24 hours.Clear paste is evaporated to relative density 1.35~1.38 (60 ℃ of heat are surveyed), and vacuum drying becomes dry extract 140g.The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose 55g, polyvinylpolypyrrolidone 13g, and mix homogeneously is made micropill.Add water and stir the system soft material in right amount, soft material is with the granulation of sieving of 14 mesh sieves, and wet granular is round as a ball, and 60 ℃ of dryings are made the 200g watered pill approximately.
Embodiment 6:Rhizoma Smilacis Bockii paste pill preparation
1500g decocts with water secondary with Rhizoma Smilacis Bockii, and each 2 hours, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, makes that to contain amount of alcohol in the solution be 20~70%, leaves standstill filtration, filtrate recycling ethanol 24 hours.Clear paste is evaporated to relative density 1.15~1.25 (60 ℃ of heat are surveyed), is spray dried to dry extract 50g; The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose 85g, polyvinylpolypyrrolidone 6g, mix homogeneously is made micropill.In addition Semen oryzae sativae powder 8.5g adds the rice that water makes and sticks with paste an amount of system soft material that stirs, and soft material is with the granulation of sieving of 14 mesh sieves, and wet granular is round as a ball, and 60 ℃ of dryings are made the 200g paste pill approximately.
Embodiment 7:Bock greenbrier rhizome micro pill
Rhizoma Smilacis Bockii dry extract 100g adds microcrystalline Cellulose 70g, polyvinylpolypyrrolidone 10g makes micropill 200g according to conventional method, promptly.
Embodiment 8:Bock greenbrier rhizome micro pill
Rhizoma Smilacis Bockii dry extract 104g adds microcrystalline Cellulose 55g, polyvinylpolypyrrolidone 13g makes micropill 200g according to conventional method, promptly.
Embodiment 9:Bock greenbrier rhizome micro pill
Rhizoma Smilacis Bockii dry extract 50g adds microcrystalline Cellulose 85g, polyvinylpolypyrrolidone 6g makes micropill 200g according to conventional method, promptly.
Embodiment 10:Bock greenbrier rhizome micro pill
Rhizoma Smilacis Bockii 1500g is added 4 times of water gagings to be decocted twice, each 1 hour, collecting decoction, be concentrated into relative density and be 1.12~1.16 clear paste, add 85% ethanol and make and contain the alcohol amount and reach 60%, fully stir, leave standstill more than 3 hours, centrifugal, supernatant reclaims ethanol, is concentrated into relative density and is 1.14~1.18 clear paste; Rhizoma Smilacis Bockii dry extract 104g is added microcrystalline Cellulose 55g, polyvinylpolypyrrolidone 13g mix homogeneously, make micropill 200g.
Embodiment 11:Bock greenbrier rhizome micro pill
Rhizoma Smilacis Bockii 1500g is added 8 times of water gagings to be decocted 2 times, each 1 hour, collecting decoction, centrifugal, filtrate is passed through styrene tyle macroporous adsorption resin, with 0.2 parts by volume water elution, discard eluent, use 55% 0.1 parts by volume ethanol and 0.6 parts by volume water elution more successively, merge eluent, reclaim ethanol, be concentrated into relative density and be 1.06~1.40 clear paste 50g; The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose 85g, polyvinylpolypyrrolidone 6g mix homogeneously, make micropill 200g.
Claims (10)
1, a kind of medicament pellet is characterized in that this medicament pellet is to be made by the raw material of following weight parts:
Rhizoma Smilacis Bockii dry extract 45-150 weight portion, add microcrystalline Cellulose 50-90 weight portion, polyvinylpolypyrrolidone 5-15 weight portion.
2, medicament pellet as claimed in claim 1 is characterized in that this medicament pellet is to be made by the raw material of following weight parts:
Rhizoma Smilacis Bockii dry extract 120 weight portions, add microcrystalline Cellulose 70 weight portions, polyvinylpolypyrrolidone 10 weight portions.
3, medicament pellet as claimed in claim 1 is characterized in that this medicament pellet is to be made by the raw material of following weight parts:
Rhizoma Smilacis Bockii dry extract 140 weight portions, add microcrystalline Cellulose 55 weight portions, polyvinylpolypyrrolidone 13 weight portions.
4, medicament pellet as claimed in claim 1 is characterized in that this medicament pellet is to be made by the raw material of following weight parts:
Rhizoma Smilacis Bockii dry extract 50 weight portions, add microcrystalline Cellulose 85 weight portions, polyvinylpolypyrrolidone 6 weight portions.
5,, it is characterized in that the Rhizoma Smilacis Bockii dry extract in this medicament pellet is prepared by following method as claim 1,2,3 or 4 described medicament pellets:
Rhizoma Smilacis Bockii is decocted with water 1-3 time, and each 1-3 hour, collecting decoction filtered, and filtrate is concentrated in right amount, adds ethanol, made that to contain amount of alcohol in the solution be 20~70%, left standstill filtration, filtrate recycling ethanol 12-36 hour; Clear paste is evaporated to relative density 1.15~1.25, is spray dried to dry extract; Or being evaporated to relative density 1.35~1.38, vacuum drying becomes dry extract.
6, the preparation method of medicament pellet as claimed in claim 5 is characterized in that this method is:
The Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone mix homogeneously; Add water and stir the system soft material, soft material is with the granulation of sieving of 10-20 mesh sieve, and wet granular is round as a ball, and 50-80 ℃ of drying made micropill, promptly.
7,, it is characterized in that this medicament pellet also can be made into the honeyed pill of clinical acceptance, water-honeyed pill, the watered pill, paste pill, wax pill, concentrated pill as claim 1,2,3 or 4 described medicament pellets.
8, the preparation method of water-honeyed pill as claimed in claim 7, it is characterized in that this method is: the Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone, mix homogeneously is made micropill; Add an amount of general ball of water with refined honey 30~40 weight portions, drying is made water-honeyed pill, promptly.
9, the preparation method of the watered pill as claimed in claim 7, it is characterized in that this method is: the Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone, mix homogeneously is made micropill; Use water pill, drying is made the watered pill, promptly.
10, the preparation method of paste pill as claimed in claim 7, it is characterized in that this method is: the Rhizoma Smilacis Bockii dry extract is broken into fine powder, adds microcrystalline Cellulose, polyvinylpolypyrrolidone, mix homogeneously is made micropill; Adding adds the rice paste that water is made with Semen oryzae sativae powder 7-10 weight portion, pill, and drying is made paste pill, promptly.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103566055A (en) * | 2013-09-26 | 2014-02-12 | 许力宏 | Callicarpa nudiflora pellet capsule as well as preparation method thereof |
CN106798816A (en) * | 2017-03-16 | 2017-06-06 | 贵州健瑞安药业有限公司 | A kind of Smilax china L semisolid preparation |
CN106798867A (en) * | 2017-04-05 | 2017-06-06 | 怀化正好制药有限公司 | A kind of Smilax china L ball and its preparation technology |
-
2005
- 2005-07-01 CN CNB200510080293XA patent/CN100500195C/en active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103566055A (en) * | 2013-09-26 | 2014-02-12 | 许力宏 | Callicarpa nudiflora pellet capsule as well as preparation method thereof |
CN103566055B (en) * | 2013-09-26 | 2014-09-24 | 许力宏 | Callicarpa nudiflora pellet capsule as well as preparation method thereof |
CN106798816A (en) * | 2017-03-16 | 2017-06-06 | 贵州健瑞安药业有限公司 | A kind of Smilax china L semisolid preparation |
CN106798867A (en) * | 2017-04-05 | 2017-06-06 | 怀化正好制药有限公司 | A kind of Smilax china L ball and its preparation technology |
CN106798867B (en) * | 2017-04-05 | 2018-01-26 | 怀化正好制药有限公司 | A kind of Smilax china L ball and its preparation technology |
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