CN1709210A - Microporous structure blood vessel stent - Google Patents
Microporous structure blood vessel stent Download PDFInfo
- Publication number
- CN1709210A CN1709210A CN 200510040936 CN200510040936A CN1709210A CN 1709210 A CN1709210 A CN 1709210A CN 200510040936 CN200510040936 CN 200510040936 CN 200510040936 A CN200510040936 A CN 200510040936A CN 1709210 A CN1709210 A CN 1709210A
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- China
- Prior art keywords
- micropore
- arc section
- bar
- cradling piece
- blood vessel
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Abstract
The present invention relates to a blood vessel support with micro pore structure. It has a reticular structure made of metal micro tube graven by laser, and the described reticular structure is characterized by that it is formed from several groups of micro pore supporting rings which are connected by means of micro pore connection curved bars, the described every group of micro pore supporting rings is formed from 4-16 unit waves, and adjacent two micro pore supporting rings are connected by adopting 2-16 micro pore connection curved bars, and the described unit wave is formed from flat straight part and curved part. Said micro pore structure support can be favorable for loading medicine, can raise medicine-loaded quantity; and is easy to control and release.
Description
Technical field
The present invention relates to a kind of expanding intravascular stent of puncture shaping surgery treatment angiemphraxis.Be specifically related to a kind of micropore bracing ring and be connected the micropore intravascular stent that curved bar combines with micropore, belong to the technical field that medical apparatus and instruments is made.
Background technology
Successful percutaneous transluminal coronary angioplasty (Percutaneous transluminalcoronary angioplasty, PTCA) postoperative still has 30～50% restenosis generation in 3～6 months, and the generation of restenosis has become the noticeable research focus in Wicresoft interventional therapy cardiovascular disease field.
Deepening continuously of the mechanism research that restenosis is taken place along with people finds that it is three main causes that cause restenosis that Wicresoft's interventional therapy causes smooth muscle cell proliferation, thrombosis and the blood vessel wall of vascular damaged initiation to reinvent.Keeping local high drug level and secular medicine controlled releasing is the main method of the preceding two kinds of reasons of treatment, and the implant frame art plays the support effect to injured blood vessel, can reduce the influence that blood vessel wall is reinvented, and becomes to solve the main method that blood vessel wall is reinvented.So people have produced implant frame naturally as pharmaceutical carrier, carry out the mode of topical and treat restenosis, and made coating stent of medicine (drug-eluting stents).But existing coating stent of medicine adds the medicine coating on general bare bracket surface mostly, support Design does not take into full account the characteristics of its medicine carrying, therefore it is uncontrollable that its structure has drug release rate, simultaneously because support coating surface only can cover 5～12% of tunica intima face, thereby its drug loading is limited shortcoming, also has the restenosis about 10% to take place.For this reason, the present invention has designed a kind of microcellular structure support that is beneficial to medicine carrying more effectively from improving the angle of structure, to overcome the deficiency of existing support.
Summary of the invention
Technical problem; The purpose of this invention is to provide a kind of microporous structure blood vessel stent so that in microcellular structure medicine carrying, improve the support drug loading, or carry a radioactive source and carry out local radiotherapy in the body, or carry microsensor and other have the small apparatus of treatment or diagnosis.
Technical scheme: the present invention is achieved through the following technical solutions its purpose: this support reticulates structure by the metal microtubule through laser engraving, described network structure connects curved bar by some groups of micropore bracing rings by micropore and is formed by connecting, every group of micropore bracing ring adopted 2～16 micropores to connect curved bar and connected by 4～16 unit wave components between the adjacent micropore bracing ring; The unit ripple is made up of flat segments and arc section, and wherein micropore connects curved bar and connects curved bar or segmental arc pore type connection curved bar for the straight section pore type.
Related content and variation further are explained as follows in the technique scheme:
1, described " microcellular structure " be meant frame support rails be connected curved bar on the structure of laser engraving micropore.Described " micropore bracing ring " is meant the circulus that is made of continuously a plurality of unit ripple.Described " unit ripple " refers to a supporting construction in the bracing ring.
2, in the technique scheme, described micropore bracing ring unit popin straight section comprises following variation from structure:
The flat segments of unit ripple is " string sugarcoated haws on a stick symmetric form " bar, and micropore is positioned at cradling piece width center, and the tapping periphery is widened; Or the flat segments of unit ripple is " string sugarcoated haws on a stick eccentrically arranged type " bar, and the micropore position is offset the 1/4-1/2 bar in the same way along cradling piece width center wide, and the tapping periphery is widened; Or the flat segments of unit ripple is " string sugarcoated haws on a stick alternate bias type " bar, and alternately oppositely skew 1/4-1/2 bar is wide along cradling piece width center in the micropore position, and the tapping periphery is widened.
3, in the technique scheme, described micropore bracing ring unit ripple arc section comprises following variation from structure:
The arc section of unit ripple is a single hole centre type arc section, and micropore is positioned at cradling piece arc section width center, and the tapping periphery is widened; Or the arc section of unit ripple is single hole offset-type arc section, and the micropore position is offset the 1/4-1/2 bar in the same way along cradling piece width center wide, and the tapping periphery is widened; Or the arc section of unit ripple is ears center pass arc section, and micropore is positioned at cradling piece arc section width center, and the tapping periphery is widened; Or the arc section of unit ripple is ears skews pass arc section, and the micropore position is offset the 1/4-1/2 bar in the same way along cradling piece width center wide, and the tapping periphery is widened.
4, in the technique scheme, described micropore comprises following variation from planform:
The micropore of described cradling piece is a circular port, or square opening, or the grooved hole, or slotted eye, or tri-angle-holed.
The micropore of described cradling piece is used for medicine carrying, improves the support drug loading, or carries a radioactive source and carry out local radiotherapy in the body, or carries microsensor and other have the small apparatus of treatment or diagnosis.
The technology of the present invention core is: at first, frame support rails be connected curved bar on carve microcellular structure, secondly, near micropore, make material and do not reduce the mechanical property of material, and this structure support press hold or when expanding micropore can not be out of shape, therefore to carrying the deposits yields influence in the micropore.Drug loading when this structural design is beneficial to as pharmaceutical carrier greatly also can be used for carrying radioactive source and carries out local radiotherapy in the body, and can be used for carrying microsensor and other small apparatuses that has treatment or diagnose.
Operation principle of the present invention is: be different from the design of existing bracket for eluting medicament, but characteristics at support medicine carrying and requirement controlled release, employing frame support rails be connected curved bar on engraving micropore and the new structural design strengthened, microcellular structure support of the present invention is beneficial to the support medicine carrying, improve drug loading, and be easy to controlled release; Microcellular structure support of the present invention also can be used for loading radioactive source and carries out local radiotherapy in the body; Microcellular structure support of the present invention also can be used for carrying microsensor and other have the small apparatus of treatment or diagnosis, has broad application prospects.
Description of drawings
Fig. 1 is a micropore bracing ring of the present invention unit popin straight section bar sketch map; Wherein Fig. 1 a is string sugarcoated haws on a stick symmetric form bar sketch map; Fig. 1 b is string sugarcoated haws on a stick eccentrically arranged type bar sketch map; Fig. 1 c is string sugarcoated haws on a stick alternate bias type bar sketch map.
Fig. 2 is a micropore bracing ring of the present invention unit ripple arc section structural representation; Wherein Fig. 2 a is a single hole centre type arc section structural representation; Fig. 2 b is a single hole offset-type arc section structural representation; Wherein Fig. 2 c is an ears center pass arc section structural representation; Fig. 2 d is an ears skew pass arc section structural representation;
Fig. 3 connects the curved bar sketch map for micropore of the present invention; Wherein Fig. 3 a connects the curved bar sketch map for the straight section pore type; Fig. 3 b connects the curved bar sketch map for the segmental arc pore type;
Fig. 4 is a micropore shape sketch map of the present invention; Wherein Fig. 4 a is the circular port sketch map; Fig. 4 b is the square opening sketch map; Wherein Fig. 4 c is a grooved hole sketch map; Wherein Fig. 4 d is the slotted eye sketch map; Fig. 4 e is tri-angle-holed sketch map;
Fig. 5 is that the support network management framework of the embodiment of the invention one launches sketch map;
Fig. 6 is that the support network management framework of the embodiment of the invention two launches sketch map;
Have in the above accompanying drawing: bracing ring 10; Unit ripple 11; String sugarcoated haws on a stick symmetric form bar 12; String sugarcoated haws on a stick eccentrically arranged type bar 13; String sugarcoated haws on a stick alternate bias type bar 14; Single hole centre type arc section 15; Single hole offset-type arc section 16; Ears center pass arc section 17 ears skew pass arc section 18; The straight section pore type connects curved bar 21; The segmental arc pore type connects curved bar 22; Circular port 31; Square opening 32; Grooved hole 33; Slotted eye 34; Tri-angle-holed 35.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is further described:
Embodiment one: see shown in Figure 5, a kind of microporous structure blood vessel stent, this support becomes network management framework to be constituted by the metal microtubule through laser engraving.Described network management framework is formed by connecting by connecting curved bar by 8 groups of bracing rings 10, every group of bracing ring 10 is made of 6 unit ripples 11 respectively, unit ripple 11 is made of flat segments string sugarcoated haws on a stick alternate bias type bar 14 and ears skew pass arc section 18, between the adjacent supports circle 10 be 3 and connect curved bar, connecting curved bar is straight section pore type 21, connects curved bar along circumferentially evenly arranging.
Embodiment two: see shown in Figure 6, a kind of microporous structure blood vessel stent, this support becomes network management framework to be constituted by the metal microtubule through laser engraving.Described network management framework is formed by connecting by connecting curved bar by 10 groups of bracing rings 10, every group of bracing ring 10 is made of 8 unit ripples 11 respectively, unit ripple 11 is made of flat segments string sugarcoated haws on a stick symmetric form bar 12 and single hole centre type arc section 15, between the adjacent supports circle 10 be 4 and connect curved bar, connecting curved bar is segmental arc pore type 22, connects curved bar along circumferentially evenly arranging.
Frame support rails be connected curved bar on carve microcellular structure, secondly, near micropore, make material and do not reduce the mechanical property of material, and this structure support press hold or when expanding micropore can not be out of shape, therefore to carrying the deposits yields influence in the micropore.Be beneficial to the support medicine carrying, improve drug loading, and be easy to controlled release; Microcellular structure support of the present invention also can be used for loading radioactive source and carries out local radiotherapy in the body; Microcellular structure support of the present invention also can be used for carrying microsensor and other have the small apparatus of treatment or diagnosis, has broad application prospects.
Claims (6)
1, a kind of microporous structure blood vessel stent, it is characterized in that: this support reticulates structure by the metal microtubule through laser engraving, described network structure connects curved bar by some groups of micropore bracing rings (10) by micropore and is formed by connecting, every group of micropore bracing ring (10) is made up of 4～16 unit ripples (11), adopts 2～16 micropores to connect curved bar between the adjacent micropore bracing ring (10) and connects; Unit ripple (11) is made up of flat segments and arc section, and wherein micropore connects curved bar and connects curved bar (21) or segmental arc pore type connection curved bar (22) for the straight section pore type.
2, microporous structure blood vessel stent according to claim 1 is characterized in that: the material of used metal microtubule is medical stainless steel or cochrome or niti-shaped memorial alloy.
3, microporous structure blood vessel stent according to claim 1 is characterized in that: the flat segments of unit ripple (11) is string sugarcoated haws on a stick symmetric form bar (12), and micropore is positioned at cradling piece width center, and the tapping periphery is widened; Or the flat segments of unit ripple (11) for the string sugarcoated haws on a stick eccentrically arranged type bar (13), the micropore position is offset the 1/4-1/2 bar in the same way along cradling piece width center wide, the tapping periphery is widened; Or the flat segments of unit ripple (11) is " string sugarcoated haws on a stick alternate bias type " bar (14), and alternately oppositely skew 1/4-1/2 bar is wide along cradling piece width center in the micropore position, and the tapping periphery is widened.
4, microporous structure blood vessel stent according to claim 1 is characterized in that: the arc section of unit ripple (11) is a single hole centre type arc section (15), and micropore is positioned at cradling piece arc section width center, and the tapping periphery is widened; Or the arc section of unit ripple (11) is single hole offset-type arc section (16), and the micropore position is offset the 1/4-1/2 bar in the same way along cradling piece width center wide, and the tapping periphery is widened; Or the arc section of unit ripple (11) is ears center pass arc section (17), and micropore is positioned at cradling piece arc section width center, and the tapping periphery is widened; Or the arc section of unit ripple (11) is ears skews pass arc section (18), and the micropore position is offset the 1/4-1/2 bar in the same way along cradling piece width center wide, and the tapping periphery is widened.
5, microporous structure blood vessel stent according to claim 1 is characterized in that: the micropore of described cradling piece is circular port (31), or square opening (32), or grooved hole (33), or slotted eye (34), or tri-angle-holed (35).
6, microporous structure blood vessel stent according to claim 1, it is characterized in that: the micropore of described cradling piece is used for medicine carrying, improve the support drug loading, or carry a radioactive source and carry out local radiotherapy in the body, or carry microsensor and other have the small apparatus of treatment or diagnosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510040936 CN100471470C (en) | 2005-07-08 | 2005-07-08 | Microporous structure blood vessel stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510040936 CN100471470C (en) | 2005-07-08 | 2005-07-08 | Microporous structure blood vessel stent |
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| Publication Number | Publication Date |
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| CN1709210A true CN1709210A (en) | 2005-12-21 |
| CN100471470C CN100471470C (en) | 2009-03-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510040936 Expired - Fee Related CN100471470C (en) | 2005-07-08 | 2005-07-08 | Microporous structure blood vessel stent |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009052703A1 (en) * | 2007-10-17 | 2009-04-30 | Microport Medical (Shanghai) Co., Ltd. | Nested stent in body lumen |
| US7607208B2 (en) | 1996-12-30 | 2009-10-27 | Sorin Biomedica Cardio S.R.L. | Method of making a medicated stent |
| WO2010083770A1 (en) * | 2009-01-23 | 2010-07-29 | 微创医疗器械(上海)有限公司 | Vascular stent with biological polypeptides |
| CN101327343B (en) * | 2007-06-20 | 2012-05-23 | 乐普（北京）医疗器械股份有限公司 | Compound medicament intravascular stent and preparation method thereof |
| CN102824236A (en) * | 2011-06-16 | 2012-12-19 | 乐普（北京）医疗器械股份有限公司 | Bioabsorbable polymer scaffold matrix as well as preparation method and application thereof |
| CN102920539A (en) * | 2012-11-12 | 2013-02-13 | 淮阴工学院 | Intravascular stent in imitating carbon nanotube structure |
| CN104127269A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent |
| CN104352293A (en) * | 2014-11-25 | 2015-02-18 | 北京航空航天大学 | Drug eluting stent capable of reducing late thrombosis |
| CN110384575A (en) * | 2013-03-15 | 2019-10-29 | 威廉·L·亨特 | Bracket monitor component and its application method |
| US11911141B2 (en) | 2014-06-25 | 2024-02-27 | Canary Medical Switzerland Ag | Devices, systems and methods for using and monitoring tubes in body passageways |
-
2005
- 2005-07-08 CN CN 200510040936 patent/CN100471470C/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7607208B2 (en) | 1996-12-30 | 2009-10-27 | Sorin Biomedica Cardio S.R.L. | Method of making a medicated stent |
| US7739781B2 (en) | 1996-12-30 | 2010-06-22 | Sorin Biomedica Cardio S.R.L | Process for producing a stent for angioplasty |
| US7946019B2 (en) | 1996-12-30 | 2011-05-24 | Sorin Biomedica Cardio S.R.L. | Process for producing a stent for angioplasty |
| CN101327343B (en) * | 2007-06-20 | 2012-05-23 | 乐普（北京）医疗器械股份有限公司 | Compound medicament intravascular stent and preparation method thereof |
| WO2009052703A1 (en) * | 2007-10-17 | 2009-04-30 | Microport Medical (Shanghai) Co., Ltd. | Nested stent in body lumen |
| WO2010083770A1 (en) * | 2009-01-23 | 2010-07-29 | 微创医疗器械(上海)有限公司 | Vascular stent with biological polypeptides |
| CN102824236A (en) * | 2011-06-16 | 2012-12-19 | 乐普（北京）医疗器械股份有限公司 | Bioabsorbable polymer scaffold matrix as well as preparation method and application thereof |
| CN102824236B (en) * | 2011-06-16 | 2016-01-20 | 乐普（北京）医疗器械股份有限公司 | A kind of biologically absorbable polymer rest body and its preparation method and application |
| CN102920539A (en) * | 2012-11-12 | 2013-02-13 | 淮阴工学院 | Intravascular stent in imitating carbon nanotube structure |
| CN102920539B (en) * | 2012-11-12 | 2015-04-22 | 淮阴工学院 | Intravascular stent in imitating carbon nanotube structure |
| CN110384575A (en) * | 2013-03-15 | 2019-10-29 | 威廉·L·亨特 | Bracket monitor component and its application method |
| CN110384575B (en) * | 2013-03-15 | 2023-11-17 | 卡纳里医疗公司 | Bracket monitoring assembly and use method thereof |
| CN104127269A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent |
| CN104127269B (en) * | 2014-06-16 | 2017-01-18 | 苏州固基电子科技有限公司 | Vascular stent |
| US11911141B2 (en) | 2014-06-25 | 2024-02-27 | Canary Medical Switzerland Ag | Devices, systems and methods for using and monitoring tubes in body passageways |
| CN104352293A (en) * | 2014-11-25 | 2015-02-18 | 北京航空航天大学 | Drug eluting stent capable of reducing late thrombosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100471470C (en) | 2009-03-25 |
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Inventor after: Gu Xingzhong Inventor after: Ni Zhonghua Inventor after: Yi Hong Inventor after: Tang Wencheng Inventor after: Wang Yuexuan Inventor before: Ni Zhonghua Inventor before: Gu Xingzhong Inventor before: Yi Hong Inventor before: Tang Wencheng Inventor before: Wang Yuexuan |
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| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: NI ZHONGHUA GU XINGZHONG YI HONG TANG WENCHENG WANG YUEXUAN TO: GU XINGZHONG NI ZHONGHUA YI HONG TANG WENCHENG WANG YUEXUAN |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090325 Termination date: 20160708 |