CN1698849A - Chinese medicine preparation for treating acute pharyngitis and acute tonsillitis and its preparation method - Google Patents
Chinese medicine preparation for treating acute pharyngitis and acute tonsillitis and its preparation method Download PDFInfo
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- CN1698849A CN1698849A CNA2005102003452A CN200510200345A CN1698849A CN 1698849 A CN1698849 A CN 1698849A CN A2005102003452 A CNA2005102003452 A CN A2005102003452A CN 200510200345 A CN200510200345 A CN 200510200345A CN 1698849 A CN1698849 A CN 1698849A
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Abstract
The invention discloses a Chinese medicine preparation for treating acute pharyngitis and acute tonsillitis and its preparation method, which comprises charging water into wild tobacco leaf, Woodfordia fruticos, ardisia japonica, folium elaeagni, batryticated silkworm, Schizonepeta tenuifolia, and peppermint, immersing 30min, grilling three times, gathering volatile oil, merging the grilling liquid, filtrating, concentrating the filtrate to clear grease with specific gravity of 1.25 (80 deg C), charging cane sugar, bed blending, obtaining particles from and drying, charging the volatile oil, dissolving with right amount of ethanol, finally bed blending.
Description
Technical field:
The invention belongs to a kind of Chinese medicine preparation and production method thereof for the treatment of acute inflammation of the throat and acute tonsillitis, belong to technical field of medicaments.
Technical background:
Acute inflammation of the throat claims acute pharyngitis due to wind-heat again, is equivalent to acute pharyngitis, because of the primary disease etiology and pathology has the different of wind heat and the deficiency of YIN, so the sore throat that wind-heat evil toxin is caused is called acute pharyngitis due to wind-heat, i.e. acute inflammation of the throat.Acute pharyngitis due to wind-heat often sharply changes because of weather, and daily life is careless, and lung is defended imbalance, and is that wind-heat evil toxin take advantage of a weak point in opponent's defence to be invaded, and directly attacks throat from mouth and nose, and internal injury is in lung, and the knot mutually of fighting mutually causes laryngopharynx swelling and pain and is sore throat.Acute tonsillitis claims acute tonsillitis caused by pathogenic windheat again, is equivalent to the modern medicine acute tonsillitis, and its site of pathological change is at the pharyngeal tonsils place of bottleneck throat both sides, and card is seen the pharyngeal tonsils congestion and swelling pain, because of its shape such as nipple, or as Bombycis mori, so the name tonsillitis.Acute inflammation of the throat (acute pharyngitis), acute tonsillitis (acute tonsillitis) all because of suffer from cold, during situation such as fatigue, Abwehrkraft des Koepers descends, viral infection often is guide's secondary bacterial infection, staphylococcus aureus, streptococcus is the common bacteria of pharyngeal infection, the suitable wind and heat dispersing of the rule of treatment, resolving toxin and disinhibiting the throat, reducing swelling and alleviating pain.At present the medicine of the above-mentioned disease of treatment commonly used is a lot, but unsatisfactory curative effect mostly, have in addition side effect is arranged, can not well be patient's use.
Summary of the invention:
The objective of the invention is to: Chinese medicine preparation and production method thereof that a kind of treatment acute inflammation of the throat (acute pharyngitis) and acute tonsillitis (acute tonsillitis) are provided, this medicine not only has the effect of heat-clearing and toxic substances removing, detumescence sore-throat relieving, but also have antiinflammatory and the effect that suppresses staphylococcus aureus, streptococcus and viral growth, for the laryngopharynx swelling and pain due to acute inflammation of the throat (acute pharyngitis), the acute tonsillitis (acute tonsillitis) reasonable therapeutic effect is arranged, have no side effect.In addition, its preparation method is easy, and medical material is easy to get, and production cost is low.
The present invention is achieved in that it mainly is to be made by following bulk drugs: Folium solani verbascifolii 400-500 part, Herba Inulae cappae 400-500 part.
Wherein the accurate consumption of crude drug is: 468.7 parts of Folium solani verbascifoliis, 468.7 parts of Herba Inulae cappae.
Said medicine wherein crude drug also has: Herba Ardisiae Japonicae 300-400 part, Folium Radix seu Fructus Actinidiae Purpureae 300-400 part, Bombyx Batryticatus 300-400 part, Herba Schizonepetae 300-400 part, Herba Menthae 300-400 part.
Wherein the accurate consumption of each component is: 468.7 parts of Folium solani verbascifoliis, 468.7 parts of Herba Inulae cappae, 312.5 parts of Herba Ardisiae Japonicaes, 312.5 parts of Folium Radix seu Fructus Actinidiae Purpureaes, 312.5 parts of Bombyx Batryticatus, 312.5 parts of Herba Schizonepetae, 312.5 parts of Herba Menthaes.
Also be added with 835 parts of sucrose therein.
Manufacturing method for above mentioned medicine: Folium solani verbascifolii, Herba Inulae cappae, Herba Ardisiae Japonicae, Folium Radix seu Fructus Actinidiae Purpureae, Bombyx Batryticatus, Herba Schizonepetae, the above seven flavor medicine material of Herba Menthae are soaked 30min, decoct three times, each 1 hour, collect volatile oil simultaneously, standby; Collecting decoction filters, and filtrate decompression is concentrated into the clear paste that relative density is 1.25 (80 ℃), adds sucrose, and mixing is made granule, and drying adds above-mentioned volatile oil (making dissolving in right amount with ethanol), mixing, promptly.
Also can it be prepared into tablet, pill, aerosol according to the common process of pharmacy.
Wherein Folium solani verbascifolii has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, adds the effect that Herba Inulae cappae increases wind-dispelling heat-dissipating, removing toxic substances and promoting subsidence of swelling; The adding Herba Ardisiae Japonicae plays the effect of promoting diuresis to eliminate damp pathogen, blood circulation promoting and blood stasis dispelling; Adding Folium Radix seu Fructus Actinidiae Purpureae is in order to reach the repercussive purpose better; Bombyx Batryticatus has dissipating phlegm and resolving masses, the functions of detumescence, relieving inflammation effect; In order to reach the effect of antimicrobial antiphlogistic and analgesic better, added Herba Schizonepetae in the prescription; Herba Menthae has the effect of refrigerant analgesic, reducing swelling and alleviating pain, can play the effect of eliminating the foreign body in pharynx sense; In order to cover the poor taste of medicine, in prescription, add correctives Zhao sucrose.
Compared with prior art, the present invention has the effect of heat-clearing and toxic substances removing, relieving sore throat and pain, and preparation method is easy, and production cost is low, is mainly used in the laryngopharynx swelling and pain due to acute inflammation of the throat (acute pharyngitis), the acute tonsillitis (acute tonsillitis).Using method is oral, a 10g, 3 times on the one.Open country pharynx leaf used among the present invention is the dry herb of feverfew smoke pipe head grass and Herba Carpesii Divaricati, Herba Inulae cappae is the fresh or dry herb of feverfew Herba Inulae cappae, Herba Ardisiae Japonicae is the dry Herb of Myrsinacea plant PINGDIMU, more than three kinds of medical materials be the medication among the people of minority area, Guizhou Province.Folium Radix seu Fructus Actinidiae Purpureae is the dried leaves of Elaeangnaceae plant Fructus Elaeagni, Fructus elaeagni glabrae or Yichang Fructus Elaeagni; Herba Menthae is the dry aerial parts of labiate Herba Menthae; Bombyx Batryticatus is that the larva of Bombycidae insecticide silkworm is all because of infecting the lethal drying of light color silk Cordycepps muscardine; Herba Schizonepetae is herb and flower (really) fringe of Labiatae Nepeta Herba Schizonepetae.This product has the effect of heat-clearing and toxic substances removing, detumescence sore-throat relieving, and is obvious to the laryngopharynx swelling and pain curative effect due to acute inflammation of the throat (acute pharyngitis), the acute tonsillitis (acute tonsillitis), has no side effect, and taking convenience is easy to accept into extensive patients.
The specific embodiment:
Below by testing the beneficial effect of further setting forth medicine of the present invention:
Observed 90 examples altogether, wherein 60 examples (acute pharyngitis 30 examples, acute tonsillitis 30 examples) are organized in treatment, matched group 30 examples (acute pharyngitis 15 examples, acute tonsillitis 15 examples).Observed result: the present invention is 63.32% to the obvious effective rate of acute pharyngitis, and total effective rate is 96.66%; The obvious effective rate of acute tonsillitis is 60%, and total effective rate is 90%.
Clinical data
One, case is selected
1, observe disease: tcm diagnosis is acute inflammation of the throat, acute tonsillitis, and Western medicine diagnose is that acute pharyngitis, acute tonsillitis are main.
2, the age: Chinese and western medicine was diagnosed clear and definite person in 18 years old to 65 years old.
3, sex: the men and women takes into account.
4, be in hospital and clinic case, can finish whole observation index persons.
5, get rid of object:
The acute pharyngitis of acute infectious disease performance, or the hematologic disease acute pharyngitis, the chronic tonsillitis that cause;
Age is under-18s over-65s person;
Be associated with serious primary disease such as cardiovascular, liver, kidney and hemopoietic system;
Gestation or women breast-feeding their children;
To this medicine allergy sufferers.
Two, physical data
Observe acute pharyngitis 45 examples altogether, wherein 30 examples are organized in treatment, male's 16 examples, women's 14 examples; Age reckling 18 years old, the maximum 61 years old; The shortest person of the course of disease 1 day, elder 10 days.Matched group 15 examples, male's 10 examples, women's 5 examples; Age reckling 20 years old, the maximum 61 years old; The shortest person of the course of disease 1 day, 1 week of elder.Acute tonsillitis 45 examples, wherein 30 examples are organized in treatment, male's 13 examples, women's 17 examples; Age reckling 19 years old, the maximum 58 years old; Matched group 15 examples, male's 9 examples, women's 6 examples; Age reckling 20 years old, the maximum 50 years old.Treatment group and matched group are close substantially from pairing factors such as diagnosis, state of an illness weight, the course of disease, sex, ages.It is 2: 1 that population proportion is closed.
Three, Therapeutic Method
The treatment group: acute pharyngitis, oral the present invention, each 1 bag (heavy 10g), 3 times on the one, five is a course of treatment; Acute tonsillitis, oral the present invention, each 2 bags (heavy 20g), 3 times on the one, five is a course of treatment.
Matched group: acute pharyngitis, oral LIYAN JIEDU CHONGJI, each 1 bag, 3 times on the one, the course of treatment is consistent with the treatment group; Acute tonsillitis, oral pills for throat disease, each 10,3 times on the one, the course of treatment is consistent with the treatment group.
The treatment viewing duration, heat-clearing and toxic substances removing, the antibiotic Chinese and western drugs of stop using other buccal or for oral administration and injection.
Four, observed result
Curative effect judging standard: formulate according to new Chinese medicine treatment acute pharyngitis, acute tonsillitis clinical research guideline that Ministry of Public Health bureau of drug administration issues.Be divided into clinical cure, produce effects, effective, invalid level Four.
1, to the efficacy result of acute pharyngitis
Treat acute pharyngitis 30 examples altogether, curative effect sees Table 1, and obvious effective rate is 63.32%, and total effective rate is 96.66%.
The present invention is to the curative effect table 1 of acute pharyngitis
| Observation unit | The example number | Clinical cure | Produce effects | Effectively | Invalid | Effectively total |
| Example number %) | ||||||
| The attached institute of your doctor | ??10 | ??5(50.00) | ??2(20.00) | ??2(20.00) | ??1(10.00) | ??9(90.00) |
| Abide by doctor two attached institutes | ??10 | ??0(0.00) | ??7(70.00) | ??3(30.00) | ??0(0.00) | ??10(100.00) |
| 44 hospitals | ??10 | ??3(30.00) | ??2(20.00) | ??5(50.00) | ??0(0.00) | ??10(100.00) |
| Mouth pI | ??30 | ??8(26.66) | ??11(36.66) | ??10(33.33) | ??1(3.33) | ??29(96.66) |
2, acute pharyngitis treatment group of the present invention and matched group curative effect are relatively
In the clinical verification process of the present invention, matched group is set in accordance with regulations, basic consistent from pairing factors such as diagnosis, state of an illness weight, the course of disease, sex, ages with the treatment group, take the grouping of simple randomization method.Clinical in the acute pharyngitis observed result, two groups of curative effects relatively see Table 2.
Acute pharyngitis treatment group of the present invention and matched group curative effect comparison sheet 2
| Group | The example number | Clinical cure | Produce effects | Effectively | Invalid | Effectively total |
| Example number %) | ||||||
| The treatment group | ??30 | ??8(26.66) | ??11(36.66) | ??10(33.33) | ??1(3.33) | ??29(96.66) |
| Matched group | ??15 | ??2(13.33) | ??5(33.33) | ??4(26.66) | ??4(26.66) | ??11(73.33) |
Compare P＞0.05 with matched group
Learning by statistics and handle, is 0.5 with the average R value of Ridt analytic process reference group (matched group), and treatment group R value is 0.64, and 95%cl:0.08-1.2 is because of comprising 0.5, so P＞0.05.Make u-test, u=1.5714＜1.96, P＞0.05.There was no significant difference between prompting treatment group and the matched group, the curative effect of treatment group is consistent with matched group.
3, the present invention is to the efficacy result of acute tonsillitis
Three hospitals treat acute tonsillitis 30 examples altogether, and curative effect sees Table 3, and produce effects is 60%, and total effective rate is 90%.
The present invention is to the curative effect table 3 of acute tonsillitis
| Observation unit | The example number | Clinical cure | Produce effects | Effectively | Invalid | Effectively total |
| Example number %) | ||||||
| The attached institute of your doctor | ??10 | ??2(20.00) | ??2(20.00) | ??5(50.00) | ??1(10.00) | ??9(90.00) |
| Abide by doctor two attached institutes | ??10 | ??3(30.00) | ??4(40.00) | ??2(20.00) | ??1(10.00) | ??9(90.00) |
| 44 hospitals | ??10 | ??5(50.00) | ??2(20.00) | ??2(20.00) | ??1(10.00) | ??9(90.00) |
| Mouth pl | ??30 | ??10(33.33) | ??8(26.66) | ??9(30.00) | ??3(10.00) | ??27(90.00) |
4, acute tonsillitis treatment group of the present invention and matched group curative effect are relatively
In the clinical verification of the present invention, matched group is set in accordance with regulations, takes easy randomized grouping, clinical in the acute tonsillitis observed result, two groups of curative effects relatively see Table 4.
Acute tonsillitis treatment group of the present invention and matched group curative effect comparison sheet 4
| Group | The example number | Clinical cure | Produce effects | Effectively | Invalid | Effectively total |
| Example number %) | ||||||
| The treatment group | ??30 | ??10(33.33) | ??3(26.66) | ??9(30.00) | ??3(10.00) | ??27(90.00) |
| Matched group | ??15 | ??1(6.67) | ??3(20.00) | ??6(40.00) | ??5(33.33) | ??10(66.67) |
Compare with matched group, P＜0.05 is learned processing by statistics, and two groups of average Ri dit compare, u-test, and u=2.4232＞1.96, P＜0.05, there were significant differences between prompting treatment group and the matched group, and the curative effect of treatment group is better than matched group.
5, untoward reaction
All case is not all found obvious adverse reaction and other toxic and side effects in the treatment phase.
Model case
What X, the woman, 50 years old, because of the pharyngalgia of suffering from cold, odynophagia, dry pharynx, whole body was uncomfortable slightly, the course of disease 1 day.Check: the hyperemia of pharynx posterior phraynx degree soft palate, pharyngeal secretions is many slightly, has no temperature, and routine blood test is normal.Diagnosis: acute pharyngitis, differential diagnosis in tcm belongs to wind-heat syndrome.1 time 1 bag of the oral pair of logical granule of sheep sore throat, 3 times on the one.Pharyngalgia alleviated in second day, and the 3rd day pharyngalgia disappears, swallow red slightly, clinical judgement healing.
Zhu X, the man, 29 years old, pharyngalgia came to go to a doctor in 1 day.Pharyngalgia after suffering from cold, takes place in readme, odynophagia, fever fear of cold, general malaise, check the tonsil acute congestion, II ° big, and blood, routine urinalysis are normal, the diagnosing acute tonsillitis, wind heat is invaded card outward, with the present invention's treatment, each 2 bags, every day 3 times, the 3rd day pharyngalgia symptom and tonsil hyperemia obviously alleviate, and body temperature is normal.
Open XX, man, 19 years old.Systemic pain appears after suffering from cold, pharyngalgia, and the fear heating, tonsil III ° is big, and obviously congested, hemogram is normal, is diagnosed as acute tonsillitis, last sense.Give the present invention three times on the one, one time 2 bag, next day, pharyngalgia and systemic pain alleviated, check after 3 days, tonsil I ° size, hyperemia is clearly better, symptom complete obiteration after taking medicine 5 days.
The king *, the woman, 32 years old, the back pharyngalgia of suffering from cold, hoarseness, general malaise pharyngeally is diffusivity hyperemia, and tonsil is little, and hemogram is normal, is diagnosed as acute pharyngitis, last sense.Give the logical granule of two sheep sore throat three times on the one, one time one bag, transference cure after 2 days, pharyngeal congestion is clearly better, recovery from illness after taking medicine 4 days.
X recklessly, the woman, 23 years old, on that night after the bilateral amygdala gland enucleation, pharyngalgia was serious, heating, fear of cold, general malaise, gave the present invention and took 2 bags, and conscious pharyngalgia obviously alleviates after half an hour, heat moves back.Taking 3 next day can take food, and changes oral each 1 bag on the 3rd day, postoperative the 4th day, and pharyngalgia disappears substantially, takes food, and tunica albuginea forms satisfaction.
Come further to set forth the preparation method of medicine of the present invention by the following examples.
Embodiments of the invention: Folium solani verbascifolii 468.7 grams, Herba Inulae cappae 468.7 grams, Herba Ardisiae Japonicae 312.5 grams, Folium Radix seu Fructus Actinidiae Purpureae 312.5 grams, Bombyx Batryticatus 312.5 grams, Herba Schizonepetae 312.5 grams, the above seven flavor medicine material of Herba Menthae 312.5 grams are soaked 30min, decoct three times, each 1 hour, collect volatile oil simultaneously, standby; Collecting decoction filters, and filtrate decompression is concentrated into the clear paste that relative density is 1.25 (80 ℃), adds sucrose 835g, and mixing is made granule, and drying adds above-mentioned volatile oil (making dissolving in right amount with ethanol), mixing, promptly.
The present invention also can be prepared into tablet, pill, aerosol with it according to the common process of pharmacy.
Claims (7)
1. Chinese medicine preparation for the treatment of acute inflammation of the throat and acute tonsillitis, it is characterized in that: it mainly is to be made by following bulk drugs: Folium solani verbascifolii 400--500 part, Herba Inulae cappae 400--500 part.
2. according to the Chinese medicine preparation of claim 1, wherein the consumption of crude drug is: 468.7 parts of Folium solani verbascifoliis, 468.7 parts of Herba Inulae cappae.
3. according to the described medicine of claim 1, wherein crude drug also has: 300 400 parts of Herba Ardisiae Japonicaes, Folium Radix seu Fructus Actinidiae Purpureae 300-400 part, Bombyx Batryticatus 300-400 part, Herba Schizonepetae 300-400 part, Herba Menthae 300-400 part.
4. according to the described medicine of claim 3, wherein the consumption of each component is: 468.7 parts of Folium solani verbascifoliis, 468.7 parts of Herba Inulae cappae, 312.5 parts of Herba Ardisiae Japonicaes, 312.5 parts of Folium Radix seu Fructus Actinidiae Purpureaes, 312.5 parts of Bombyx Batryticatus, 312.5 parts of Herba Schizonepetae, 312.5 parts of Herba Menthaes.
5. according to the described medicine of claim 4, wherein also be added with 835 parts of sucrose.
6. preparation method as medicine as described in the claim 1,2,3,4 or 5, it is characterized in that: Folium solani verbascifolii, Herba Inulae cappae, Herba Ardisiae Japonicae, Folium Radix seu Fructus Actinidiae Purpureae, Bombyx Batryticatus, Herba Schizonepetae, the above seven flavor medicine material of Herba Menthae are soaked 30min, decoct three times, each 1 hour, collect volatile oil simultaneously, standby; Collecting decoction filters, and filtrate decompression is concentrated into the clear paste that relative density is 1.25 (80 ℃), adds sucrose, and mixing is made granule, and drying adds above-mentioned volatile oil (making dissolving in right amount with ethanol), mixing, promptly.
7. according to the preparation method of the described medicine of claim 6, it is characterized in that: also can it be prepared into tablet, pill, aerosol according to the common process of pharmacy.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103134898A (en) * | 2013-03-18 | 2013-06-05 | 贵州百灵企业集团正鑫药业有限公司 | Detection method of Shuangyang pharyngitis particles |
| CN103599154A (en) * | 2012-11-23 | 2014-02-26 | 陆超 | Application of inula cappa in preparation of medicament for preventing tonsillitis disease of children |
| CN105233110A (en) * | 2015-10-16 | 2016-01-13 | 雷霜 | Traditional Chinese medicine preparation for prevention and treatment of bovine bronchopneumonia and production method of traditional Chinese medicine preparation for prevention and treatment of bovine bronchopneumonia |
| CN105796778A (en) * | 2016-05-04 | 2016-07-27 | 包莉丽 | Medicine for treating throat obstruction pharyngitis |
| CN106389499A (en) * | 2015-08-13 | 2017-02-15 | 亚宝药业集团股份有限公司 | Drug composition with effects of clearing heat and toxins, removing swelling and relieving sore-throat |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283501A (en) * | 1999-08-04 | 2001-02-14 | 成都迪康药物研究所 | Spary for treating laryngitis and its preparing process |
| CN100337645C (en) * | 2002-02-05 | 2007-09-19 | 南京凯优科贸有限公司 | Medicine composition for treating acute pharyngitis and its prepn |
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2005
- 2005-06-22 CN CNB2005102003452A patent/CN100337648C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599154A (en) * | 2012-11-23 | 2014-02-26 | 陆超 | Application of inula cappa in preparation of medicament for preventing tonsillitis disease of children |
| CN103134898A (en) * | 2013-03-18 | 2013-06-05 | 贵州百灵企业集团正鑫药业有限公司 | Detection method of Shuangyang pharyngitis particles |
| CN106389499A (en) * | 2015-08-13 | 2017-02-15 | 亚宝药业集团股份有限公司 | Drug composition with effects of clearing heat and toxins, removing swelling and relieving sore-throat |
| CN105233110A (en) * | 2015-10-16 | 2016-01-13 | 雷霜 | Traditional Chinese medicine preparation for prevention and treatment of bovine bronchopneumonia and production method of traditional Chinese medicine preparation for prevention and treatment of bovine bronchopneumonia |
| CN105796778A (en) * | 2016-05-04 | 2016-07-27 | 包莉丽 | Medicine for treating throat obstruction pharyngitis |
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| CN100337648C (en) | 2007-09-19 |
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