CN1686535A - Preparation method of medicinal composition containing glutathione peroxidase - Google Patents
Preparation method of medicinal composition containing glutathione peroxidase Download PDFInfo
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- CN1686535A CN1686535A CN 200510046156 CN200510046156A CN1686535A CN 1686535 A CN1686535 A CN 1686535A CN 200510046156 CN200510046156 CN 200510046156 CN 200510046156 A CN200510046156 A CN 200510046156A CN 1686535 A CN1686535 A CN 1686535A
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Abstract
A Chinese medicine in the form of eyedrops containing glutathion peroxidase is prepared from 6 Chinese-medicinal materials including feather cockscomb seed, siberian solomonseal rhizome, cassia seed, chrysanthemum flower, etc. Its preparing process is also disclosed.
Description
One, technical field: what the present invention relates to be used to prevent and treat ophthalmics such as cataract, myopia a kind ofly is rich in selenic preparation of drug combination method.
Two, background technology: the high development of society, the quickening of rhythm of life, various eye class diseases are also more and more, particularly a large amount of computed crowds increase, make suffer from myopia, cataractous crowd also constantly increases, and the crowd more than 50 years old also is cataractous group of people at high risk, and these ophthalmics bring greatly inconvenience for people's life.People's eyes will be seen surroundings clearly, will possess perspective and focusing function, transparent membrane vesicle that these two kinds of functions can be regulated voluntarily by middle filled with fluid, sphericity, flat is realized, this transparent membrane vesicle is exactly an eye's lens, crystalline lens plays an important role to the dioptric and the visual accommodation of eyes, and realize the material base of this function, it but is crystalline intravital protein ingredient, it is in crystalline intravital concentration,, just in time corresponding from the center with lenticular refractive power to descending gradually all around.Crystallin is divided into soluble protein and insoluble protein, and wherein the former accounts for 8605%, and it is keeping lenticular clairvoyance just, and the latter mainly plays a role aspect dioptric.Soluble protein in the crystalline lens is divided into three kinds, and they all keep its molecular structure by " SH-" group.In the crystalline lens metabolic process, have a large amount of peroxide, peroxide radical (O
2 -, H
2O, ROOH, LOOH) produce, if can not in time be removed, they will combine with the free radical in the crystalline lens soluble protein, the CHARGE DISTRIBUTION and the molecular structure of whole protein surface can be changed, the SH-group of protein molecular inside is come out, make it to be oxidized to-the S-S-bond structure, finally make a plurality of solubility small molecular protein polymerization reaction take places, form insoluble macromolecule protein polymer, cause the perspective obstacle of crystalline lens, cataractous pathogeny that Here it is light.Under the normal situation of human physiological functions, crystalline lens self has a series of antioxidant system, as the existence of enough peroxide dismutases (SOD), catalase (CAT), peroxidase, glutathione reductase (GSH-R), glutathione peroxidase (GPX), phospholipid glutathione peroxidase (PHGPX), the peroxide that produces in can spontaneous elimination metabolic process.Preceding four kinds of enzymes, because the raw material supply source is sufficient, human body self can synthesize easily, then two kinds of enzymes is synthetic, but be affected owing to lacking specific aminoacid, human body self is difficult to synthetic, and these two kinds of enzymes are keys of prevention and ophthalmics such as treatment cataract, myopia.Along with research in recent years, it is found that selenium is trace element essential in the human body, human body is by preventing multiple disease to selenic replenishing, and therefore, the relation of selenium and health comes into one's own day by day.In the human multiple tissue cell, for the highest, selenium is the important trace element of keeping vision with the Se content of eyes, because of it is insoluble in water, so human body is extremely difficult synthetic.Traditional useful Rhizoma amorphophalli extracts the method for glutathione peroxidase pharmaceutical composition, but this method is made tablet, takes the back by the people and plays treatment, because of the difference of individual absorbing state, fails to reach optimum therapeuticing effect.
Three, summary of the invention: the invention provides a kind of glutathione peroxidase pharmaceutical composition and preparation method thereof that contains, its purpose is to provide a kind of can prevent and treat various ophthalmics, is rich in the preparation method that selenium and human body are difficult to synthetic glutathione peroxidase medicine.
The present invention comes to be realized by the following technical programs:
A kind of glutathione peroxidase preparation of drug combination method that contains, it is characterized in that: this preparation method follows these steps to carry out:
(1), by weight get Semen Celosiae 30～40: Rhizoma Polygonati 30～40: the Herba Equiseti Hiemalis 7～13: Semen Cassiae 7～13: Flos Buddlejae 3～7: Flos Chrysanthemi 3～7 is raw material, and various medicines clean respectively;
(2), crude drug is handled respectively: Semen Celosiae 50 ℃～80 ℃ oven dry of temperature 20～50 minutes, is fine powder through pulverizing to grind, in fine powder, adds water, after fully stirring, soaked 3～8 hours with fine powder weight 1/2; Add entry in Rhizoma Polygonati, water weight is equivalent to 1/3 of Rhizoma Polygonati weight, fully soaks 2～4 hours, puts into jar and pulls an oar, and fully stirs; After each raw material after the above-mentioned processing fully mixed, fully stir; Add the water identical with Herba Equiseti Hiemalis's weight in the Herba Equiseti Hiemalis, fully soaked 3～6 hours, 50 ℃～80 ℃ were heated 10～60 minutes; After the Semen Cassiae fragmentation, in Semen Cassiae, add the water identical with Semen Cassiae weight, heat to 50 ℃～80 ℃ and fried in shallow oil 10～60 minutes; After Flos Buddlejae and Flos Chrysanthemi mixing, add water with Flos Buddlejae and Flos Chrysanthemi weight and 1/3, fully soaked 2～4 hours, put into jar and pull an oar, fully stir; After each raw material after the above-mentioned processing fully mixed, fully stir;
(3), press the above-mentioned raw materials weight ratio, round reason, the medical material soak that cooks drops in the extraction pot, collecting decoction filters, and puts cold, under agitation add ethanol, make the alcohol amount of containing reach 30% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, put cold, under agitation add ethanol once more, make to contain alcohol amount and reach 55%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, cold preservation was left standstill 48 hours, filter, reclaim ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filtered, and adjust pH is 6.5--7.5, filter to clear and bright with microporous filter membrane, the microwave sterilizating of employing frequency 1000MHz～2000MHz 5～10 minutes promptly gets eye drop.
This preparation method follows these steps to carry out:
(1), by weight get Semen Celosiae 35: Rhizoma Polygonati 35: the Herba Equiseti Hiemalis 10: Semen Cassiae 10: Flos Buddlejae 5: Flos Chrysanthemi 5 is raw material, and various medicines clean respectively;
(2), crude drug is handled respectively: Semen Celosiae 50 ℃～80 ℃ oven dry of temperature 20～50 minutes, is fine powder through pulverizing to grind, in fine powder, adds water, after fully stirring, soaked 3～8 hours with fine powder weight 1/2; Add entry in Rhizoma Polygonati, water weight is equivalent to 1/3 of Rhizoma Polygonati weight, fully soaks 2～4 hours, puts into jar and pulls an oar, and fully stirs; Add the water identical with Herba Equiseti Hiemalis's weight in the Herba Equiseti Hiemalis, fully soaked 3～6 hours, 50 ℃～80 ℃ were heated 10～60 minutes; After the Semen Cassiae fragmentation, in Semen Cassiae, add the water identical with Semen Cassiae weight, heat to 50 ℃～80 ℃ and fried in shallow oil 10～60 minutes; After Flos Buddlejae and Flos Chrysanthemi mixing, add water with Flos Buddlejae and Flos Chrysanthemi weight and 1/3, fully soaked 2～4 hours, put into jar and pull an oar, fully stir; After each raw material after the above-mentioned processing fully mixed, fully stir;
(3), press the above-mentioned raw materials weight ratio, round reason, the medical material soak that cooks drops in the extraction pot, collecting decoction filters, and puts cold, under agitation add ethanol, make the alcohol amount of containing reach 30% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, put cold, under agitation add ethanol once more, make to contain alcohol amount and reach 55%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, cold preservation was left standstill 48 hours, filter, reclaim ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filtered, and adjust pH is 6.5--7.5, filter to clear and bright with microporous filter membrane, the microwave sterilizating of employing frequency 1000MHz～2000MHz 5～10 minutes promptly gets eye drop.
Advantage of the present invention and effect: the glutathione under the catalytic action of glutathione peroxidase in the human lens (being a kind of Reducing agent) can suppress the generation of harmful metabolite " peroxide " and the formation of " free radical "; thereby play the protection biomembrane and avoid its evil; thereby make crystalline lens keep normal pellucidity; reduce myopia; the sickness rate of ophthalmics such as cataract; simultaneously polymeric insoluble macromolecule protein-S-S-bond structure takes place to ophthalmic and dissociates in prepared product of the present invention, thereby makes established insoluble macromolecule protein be decomposed into the catalyzing enzyme of course of reaction of the small molecular protein of solubility again.Selenium is necessary for human body, and selenium is rich in the present invention, can provide necessary selenium for human body, replenishes eye and lacks selenic situation, ophthalmic is had excellent prevention and therapeutical effect, and other disease is also had the excellent prevention effect.
The present invention utilizes natural wild plant resource, through simple extraction process, the active ingredient of the medicine of respectively distinguishing the flavor of is fully extracted, obtain the pharmaceutical composition of the very high glutathione peroxidase of selenium content, and the present invention makes liquid eye drop, directly acts on the affected part, and medicine is effectively absorbed, reach the best prevention and the therapeutic effect of various ophthalmics such as treatment myopia, cataract, its prospect is boundless.
Four, the specific embodiment:
Semen Celosiae is seed, stem and leaf, the root of Amaranthaceae annual herb plant Herba Celosiae argenteae, claims Semen Cassiae again, with the Semen Cassiae that is called Semen Cassiae be not a kind of, bitter in the mouth, cold nature is rich in the selenium element, and the effect of diffusion pupil is arranged, liver heat removing and eyesight improving is controlled order diseases such as conjunctival congestion and swelling pain, the glaucoma patient forbidding.
Rhizoma Polygonati claims a meter dried meat again, sweet in the mouth, and property is flat, is rich in selenium, treatment myopia.
The Herba Equiseti Hiemalis claims Herba Equiseti Hiemalis, Herba Clinopodii Polycephali again, bitter in the mouth, and property is flat, function dispelling wind and heat pathogens, improving acuity of vision and removing nebula, hemostasis.
Semen Cassiae claims Semen Cassiae, horse tellurium Semen Cassiae again.Sweet in the mouth, hardship, cold nature, function cures mainly liver heat removing and eyesight improving, conjunctival congestion and swelling pain etc.
The alabastrum that Flos Buddlejae is irritated this Flos Buddlejae tree for the Loganiaceae leaf cures mainly liver-heat conjunctival congestion, the many tears of shy order, the living nebula of blurred vision.
Flos Chrysanthemi acrid in the mouth, sweet, bitter, cold nature, the function wind and heat dispersing, suppressing the hyperactive liver makes eye bright, detoxifcation.
The above-mentioned medicine of respectively distinguishing the flavor of all has the function of the treatment ophthalmic that makes eye bright, and gets Semen Celosiae by the formulation weight ratio: Herba Equiseti Hiemalis: Semen Cassiae: Flos Buddlejae: Flos Chrysanthemi=65～75: 7～13: 7～13: 3～7: 3～7 are raw material, can bring into play the curative effect of the medicine of respectively distinguishing the flavor of better.
Embodiment 1:
A kind of glutathione peroxidase preparation of drug combination method that contains, it is characterized in that: this preparation method follows these steps to carry out:
(1), getting weight ratio gets Semen Celosiae 30: Rhizoma Polygonati 30: the Herba Equiseti Hiemalis 13: Semen Cassiae 13: Flos Buddlejae 7: Flos Chrysanthemi 7 is raw material, and various medicines clean respectively;
(2), crude drug is handled respectively: Semen Celosiae 50 ℃～80 ℃ oven dry of temperature 20～50 minutes, is fine powder through pulverizing to grind, in fine powder, adds water, after fully stirring, soaked 3～8 hours with fine powder weight 1/2; Add entry in Rhizoma Polygonati, water weight is equivalent to 1/3 of Rhizoma Polygonati weight, fully soaks 2～4 hours, puts into jar and pulls an oar, and fully stirs; After each raw material after the above-mentioned processing fully mixed, fully stir; Add the water identical with Herba Equiseti Hiemalis's weight in the Herba Equiseti Hiemalis, fully soaked 3～6 hours, 50 ℃～80 ℃ were heated 10～60 minutes; After the Semen Cassiae fragmentation, in Semen Cassiae, add the water identical with Semen Cassiae weight, heat to 50 ℃～80 ℃ and fried in shallow oil 10～60 minutes; After Flos Buddlejae and Flos Chrysanthemi mixing, add water with Flos Buddlejae and Flos Chrysanthemi weight and 1/3, fully soaked 2～4 hours, put into jar and pull an oar, fully stir; After each raw material after the above-mentioned processing fully mixed, fully stir;
(3), press the above-mentioned raw materials weight ratio, round reason, the medical material soak that cooks, drop in the extraction pot, collecting decoction filters, put cold, under agitation add ethanol, make the alcohol amount of containing reach 30% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, put coldly, under agitation add ethanol once more, make and contain alcohol amount and reach 55%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, and cold preservation was left standstill 48 hours, filters, reclaim ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filter, adjust pH is 6.5--7.5, because of made liquid is directly used in eyes, so carry out above-mentioned processing, pH degree of balance when guaranteeing to use, filter to clear and bright with microporous filter membrane, the microwave sterilizating of employing frequency 1000MHz～2000MHz 5～10 minutes, microwave sterilizating is convenient and practical, and cost is low, sterilization effect is good, row when need not in hundred grades of traditional better purifying spaces, aseptic subpackaged in 20ml bottle (should give a baby a bath on the third day after its birth all over the passed examination after drying) with cobalt 60 radiation sterilizations, buckle closure, the qualified back of lamp inspection quality inspection packing promptly.
Embodiment 2:
A kind of glutathione peroxidase preparation of drug combination method that contains, it is characterized in that: this preparation method follows these steps to carry out:
(1), getting weight ratio gets Semen Celosiae 35: Rhizoma Polygonati 35: the Herba Equiseti Hiemalis 10: Semen Cassiae 10: Flos Buddlejae 5: Flos Chrysanthemi 5 is raw material, and various medicines clean respectively;
(2), crude drug is handled respectively: Semen Celosiae 50 ℃～80 ℃ oven dry of temperature 20～50 minutes, is fine powder through pulverizing to grind, in fine powder, adds water, after fully stirring, soaked 3～8 hours with fine powder weight 1/2; Add entry in Rhizoma Polygonati, water weight is equivalent to 1/3 of Rhizoma Polygonati weight, fully soaks 2～4 hours, puts into jar and pulls an oar, and fully stirs; Add the water identical with Herba Equiseti Hiemalis's weight in the Herba Equiseti Hiemalis, fully soaked 3～6 hours, 50 ℃～80 ℃ were heated 10～60 minutes; After the Semen Cassiae fragmentation, in Semen Cassiae, add the water identical with Semen Cassiae weight, heat to 50 ℃～80 ℃ and fried in shallow oil 10～60 minutes; After Flos Buddlejae and Flos Chrysanthemi mixing, add water with Flos Buddlejae and Flos Chrysanthemi weight and 1/3, fully soaked 2～4 hours, put into jar and pull an oar, fully stir; After each raw material after the above-mentioned processing fully mixed, fully stir;
(3), press the above-mentioned raw materials weight ratio, round reason, the medical material soak that cooks drops in the extraction pot, collecting decoction filters, and puts cold, under agitation add ethanol, make the alcohol amount of containing reach 30% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, put cold, under agitation add ethanol once more, make to contain alcohol amount and reach 55%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, and cold preservation was left standstill 48 hours, filters, reclaim ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filter, adjust pH is 6.5--7.5, filters to clear and bright with microporous filter membrane, the microwave sterilizating of employing frequency 1000MHz～2000MHz 5～10 minutes, aseptic subpackaged in 20ml bottle (time passed examination after drying of should giving a baby a bath on the third day after its birth, with cobalt 60 radiation sterilizations) in, buckle closure, the qualified back of lamp inspection quality inspection packing is promptly.
Embodiment 3:
A kind of glutathione peroxidase preparation of drug combination method that contains, it is characterized in that: this preparation method follows these steps to carry out:
(1), getting weight ratio gets Semen Celosiae 40: Rhizoma Polygonati 40: the Herba Equiseti Hiemalis 7: Semen Cassiae 7: Flos Buddlejae 3: Flos Chrysanthemi 3 is raw material, and various medicines clean respectively;
(2), crude drug is handled respectively: Semen Celosiae 50 ℃～80 ℃ oven dry of temperature 20～50 minutes, is fine powder through pulverizing to grind, in fine powder, adds water, after fully stirring, soaked 3～8 hours with fine powder weight 1/2; Add entry in Rhizoma Polygonati, water weight is equivalent to 1/3 of Rhizoma Polygonati weight, fully soaks 2～4 hours, puts into jar and pulls an oar, and fully stirs; Add the water identical with Herba Equiseti Hiemalis's weight in the Herba Equiseti Hiemalis, fully soaked 3～6 hours, 50 ℃～80 ℃ were heated 10～60 minutes; After the Semen Cassiae fragmentation, in Semen Cassiae, add the water identical with Semen Cassiae weight, heat to 50 ℃～80 ℃ and fried in shallow oil 10～60 minutes; After Flos Buddlejae and Flos Chrysanthemi mixing, add water with Flos Buddlejae and Flos Chrysanthemi weight and 1/3, fully soaked 2～4 hours, put into jar and pull an oar, fully stir; After each raw material after the above-mentioned processing fully mixed, fully stir;
(3), press the above-mentioned raw materials weight ratio, round reason, the medical material soak that cooks drops in the extraction pot, collecting decoction filters, and puts cold, under agitation add ethanol, make the alcohol amount of containing reach 30% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, put cold, under agitation add ethanol once more, make to contain alcohol amount and reach 55%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, and cold preservation was left standstill 48 hours, filters, reclaim ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filter, adjust pH is 6.5--7.5, filters to clear and bright with microporous filter membrane, the microwave sterilizating of employing frequency 1000MHz～2000MHz 5～10 minutes, aseptic subpackaged in 20ml bottle (time passed examination after drying of should giving a baby a bath on the third day after its birth, with cobalt 60 radiation sterilizations) in, buckle closure, the qualified back of lamp inspection quality inspection packing is promptly.
As follows to myopia and the contrast of cataract patient therapeutic effect respectively with eye drop of the present invention and the precious tablet of vision:
Treatment target: cataract patient male 10 examples, minimum 45 years old of age, maximum 65 years old, average 52 years old;
Treatment time: 15 days course of treatment;
Therapeutic Method: matched group 5 people take the precious tablet of vision, every day twice, each two;
The eye drop that 5 people use the present invention to prepare is organized in treatment, and each 3, every day three times;
The therapeutic effect contrast of the precious tablet of the present invention and traditional treatment vision is as follows:
By this cataract patient is contrasted treatment, draw precious tablet in treatment two examples of vision effectively, three examples are invalid, and an example has positive effect, and eye drop of the present invention treatment four examples effectively, two examples have positive effect, one example is invalid, is significantly improved so draw the cataractous effect of the precious tablet in treatment of eye drop contrast vision of the present invention, but should notes, because of one of principal agent in the eye drop of the present invention is a Semen Celosiae, so glaucoma patient is avoided usefulness.
| Matched group | ||||
| Before the treatment | After the treatment | |||
| Vision | Left eye | Right eye | Left eye | Right eye |
| The 1st example | ????0.4 | ????0.3 | ????0.6 | ????0.5 |
| The 2nd example | ????0.5 | ????0.6 | ????0.7 | ????0.8 |
| The 3rd example | ????0.2 | ????0.3 | ????0.2 | ????0.3 |
| The 4th example | ????0.8 | ????0.7 | ????0.8 | ????0.7 |
| The 5th example | ????0.3 | ????0.6 | ????0.3 | ????0.6 |
| The treatment group | ||||
| Before the treatment | After the treatment | |||
| Vision | Left eye | Right eye | Left eye | Right eye |
| The 6th example | ????0.3 | ????0.4 | ????0.7 | ????0.8 |
| The 7th example | ????0.3 | ????0.2 | ????0.6 | ????0.6 |
| The 8th example | ????0.5 | ????0.6 | ????1.0 | ????1.0 |
| The 9th example | ????0.6 | ????0.8 | ????0.6 | ????0.8 |
| The 10th example | ????0.5 | ????0.4 | ????1.0 | ????0.9 |
Claims (2)
1, a kind of glutathione peroxidase preparation of drug combination method that contains, it is characterized in that: this preparation method follows these steps to carry out:
(1), by weight get Semen Celosiae 30～40: Rhizoma Polygonati 30～40: the Herba Equiseti Hiemalis 7～13: Semen Cassiae 7～13: Flos Buddlejae 3～7: Flos Chrysanthemi 3～7 is raw material, and various medicines clean respectively;
(2), crude drug is handled respectively: Semen Celosiae 50 ℃～80 ℃ oven dry of temperature 20～50 minutes, is fine powder through pulverizing to grind, in fine powder, adds water, after fully stirring, soaked 3～8 hours with fine powder weight 1/2; Add entry in Rhizoma Polygonati, water weight is equivalent to 1/3 of Rhizoma Polygonati weight, fully soaks 2～4 hours, puts into jar and pulls an oar, and fully stirs; After each raw material after the above-mentioned processing fully mixed, fully stir; Add the water identical with Herba Equiseti Hiemalis's weight in the Herba Equiseti Hiemalis, fully soaked 3～6 hours, 50 ℃～80 ℃ were heated 10～60 minutes; After the Semen Cassiae fragmentation, in Semen Cassiae, add the water identical with Semen Cassiae weight, heat to 50 ℃～80 ℃ and fried in shallow oil 10～60 minutes; After Flos Buddlejae and Flos Chrysanthemi mixing, add water with Flos Buddlejae and Flos Chrysanthemi weight and 1/3, fully soaked 2～4 hours, put into jar and pull an oar, fully stir; After each raw material after the above-mentioned processing fully mixed, fully stir;
(3), press the above-mentioned raw materials weight ratio, round reason, the medical material soak that cooks drops in the extraction pot, collecting decoction filters, and puts cold, under agitation add ethanol, make the alcohol amount of containing reach 30% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, put cold, under agitation add ethanol once more, make to contain alcohol amount and reach 55%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, cold preservation was left standstill 48 hours, filter, reclaim ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filtered, and adjust pH is 6.5-7.5, filter to clear and bright with microporous filter membrane, the microwave sterilizating of employing frequency 1000MHz～2000MHz 5～10 minutes promptly gets eye drop.
2, according to containing glutathione peroxidase preparation of drug combination method described in the claim 1, it is characterized in that: this preparation method follows these steps to carry out:
(1), by weight get Semen Celosiae 35: Rhizoma Polygonati 35: the Herba Equiseti Hiemalis 10: Semen Cassiae 10: Flos Buddlejae 5: Flos Chrysanthemi 5 is raw material, and various medicines clean respectively;
(2), crude drug is handled respectively: Semen Celosiae 50 ℃～80 ℃ oven dry of temperature 20～50 minutes, is fine powder through pulverizing to grind, in fine powder, adds water, after fully stirring, soaked 3～8 hours with fine powder weight 1/2; Add entry in Rhizoma Polygonati, water weight is equivalent to 1/3 of Rhizoma Polygonati weight, fully soaks 2～4 hours, puts into jar and pulls an oar, and fully stirs; Add the water identical with Herba Equiseti Hiemalis's weight in the Herba Equiseti Hiemalis, fully soaked 3～6 hours, 50 ℃～80 ℃ were heated 10～60 minutes; After the Semen Cassiae fragmentation, in Semen Cassiae, add the water identical with Semen Cassiae weight, heat to 50 ℃～80 ℃ and fried in shallow oil 10～60 minutes; After Flos Buddlejae and Flos Chrysanthemi mixing, add water with Flos Buddlejae and Flos Chrysanthemi weight and 1/3, fully soaked 2～4 hours, put into jar and pull an oar, fully stir; After each raw material after the above-mentioned processing fully mixed, fully stir;
(3), press the above-mentioned raw materials weight ratio, round reason, the medical material soak that cooks drops in the extraction pot, collecting decoction filters, and puts cold, under agitation add ethanol, make the alcohol amount of containing reach 30% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, put cold, under agitation add ethanol once more, make to contain alcohol amount and reach 55%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, cold preservation was left standstill 48 hours, filter, reclaim ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filtered, and adjust pH is 6.5-7.5, filter to clear and bright with microporous filter membrane, the microwave sterilizating of employing frequency 1000MHz～2000MHz 5～10 minutes promptly gets eye drop.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510046156 CN1686535A (en) | 2005-04-01 | 2005-04-01 | Preparation method of medicinal composition containing glutathione peroxidase |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510046156 CN1686535A (en) | 2005-04-01 | 2005-04-01 | Preparation method of medicinal composition containing glutathione peroxidase |
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| CN1686535A true CN1686535A (en) | 2005-10-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079795A (en) * | 2015-08-21 | 2015-11-25 | 胡勇 | Organic selenium eye washing liquid and preparation method thereof |
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2005
- 2005-04-01 CN CN 200510046156 patent/CN1686535A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079795A (en) * | 2015-08-21 | 2015-11-25 | 胡勇 | Organic selenium eye washing liquid and preparation method thereof |
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