CN1686288A - Shenxian capsulea nd its preparation technology - Google Patents

Abstract

A Chinese medicine in the form of capsule for treating psoriasis, purpura, leukoderma, intractable tinea, etc is prepared from 11 Chinese-medicinal materials including flavescent sophora root, clematis root, fleece flower root, etc through pulverizing grass-leaved sweetflag rhizome, decocting others mixing, granulating, and filling in capsules.

Description

Shenxian capsulea nd and preparation technology thereof

Affiliated technical field

Shenxian capsulea nd of the present invention and preparation technology thereof belong to dermopathic medicine of treatment and preparation technology thereof, relate in particular to Chinese prescription and treat psoriatic medicine and preparation technology thereof.

Background technology

Psoriasis is a kind of common, recurrence is covered with the chronic dermatosis that silvery white squama is a main clinical manifestation with erythema easily, also claim psoriasis or psoriasis, Chinese medical discrimination is divided into blood-heat type, blood stasis type, cold type, the deficiency of the liver and kindey type, blood-dryness type five big classes, skin lesion is with red pimple, maculopapule and the red speckle that differs in size are main, be covered with the dry silvery white squama of multilamellar, after striking off squama, as seen petechial hemorrhage, with pruritus in various degree, patient's restlessness and thirst, the constipation yellow urine, lusterless complexion, dizzy few the dormancy, except that the skin lesion psoriasis, also has joint type, pustule type, erythrodermic psoriasis, the cause of disease is from wind and cold, wind heat, the heresy of pathogenic wind-warm is outer attacks, causing battalion to defend becomes estranged, internal injury caused by excess of seven emotions, QI-mass is stopped up stagnant, failure of skin and muscle to be nourished, qi-blood disharmony, or deficiency of the liver and kindey causes disharmony of Chong and Conception Channels, nothing more than with wind, heat, wet, cold, heat in blood, blood is dry, blood stasis and deficiency of the liver and kindey etc. are relevant.It is very extensive to be applied to treat psoriatic medicine at present, and traditional medium-height grass prescription proved recipe or compound preparation are arranged, and chemical medicinal treatment is arranged, the vitamin therapy is arranged, physiotherapy is arranged, but all have the high defective of relapse rate.

Summary of the invention

The objective of the invention is: provide scientific formulation to the psoriatic, compatibility is proper, the pure Chinese medicinal preparation for the treatment of both the principal and secondary aspects of a disease, reach heat clearing and damp drying, removing blood stasis dispel the wind, draw out pus by applying a plaster to the affected part collapse itch, removing obstruction in the collateral to relieve pain, can effectively cure dissimilar psoriasises, and no longer recurrence.

In order to realize the foregoing invention purpose, the technical solution adopted in the present invention is: Shenxian capsulea nd is according to psoriatic main etiology and pathogenesis, with heat clearing and damp drying, removing blood stasis dispel the wind, draw out pus by applying a plaster to the affected part collapse itch, removing obstruction in the collateral to relieve pain, nourishing the liver and kidney, nourishing blood and promoting blood circulation be principle of treatment, the crude drug total amount is 1060 grams in the prescription, is made up of Radix Sophorae Flavescentis 120 grams, Radix Clematidis 120 grams, Radix Polygoni Multiflori 100 grams, Radix Trichosanthis 80 grams, Rhizoma Chuanxiong 80 grams, Radix Angelicae Sinensis 80 grams, Fructus Cnidii 120 grams, Radix Achyranthis Bidentatae 100 grams, Rhizoma Atractylodis 80 grams, Rhizoma Acori Graminei 100 grams, Radix Glycyrrhizae 80 grams.The preparation method of Shenxian capsulea nd is divided into Rhizoma Acori Graminei powder process, many medicine decocting to thick ointment, mixed pelletization, dress capsule four road technologies, getting Rhizoma Acori Graminei earlier pulverized 80 mesh sieves and was mixed into the fine powder medicine, get Radix Sophorae Flavescentis again, Radix Trichosanthis, Radix Polygoni Multiflori, Radix Clematidis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Glycyrrhizae nine flavor Chinese herbal medicine add 10 times of water gagings and decoct for the first time, decocted 1.5 hours, filter, the Rhizoma Atractylodis immersion was added 6 times of water gagings with filtering medicinal residues after 2 hours, decoct once more for the second time, decocted 1 hour, and filtered, merge twice and decoct filtrate, it is 1.28-1.30 (60 ℃) thick paste that filtrate is concentrated into relative density, with fine powder medicine mixing, to granulate, No. 0 capsule of packing into gets patent medicine.Chinese medicine thinks that psoriasis and wind, heat, wet, cold, heat in blood, blood are dry, blood deficiency, deficiency of the liver and kindey, hypoimmunity are relevant, in Shenxian capsulea nd, Radix Sophorae Flavescentis has heat clearing and damp drying, wind dispelling insecticide effect, the directly inflammation-inhibiting reaction of contained matrine, pathogenic bacterias such as staphylococcus aureus, group B streptococcus there is obviously antibacterial action, cures mainly damp-heat dysentery, scabies, skin pruritus, noxious dampness skin infection; Radix Clematidis has the effect of expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, and decoct all has stronger inhibitory action to staphylococcus aureus and multiple Grain-positive negative bacteria and multiple tinea bacterium, cures mainly rheumatic arthralgia, numb limbs and tense tendons; Radix Polygoni Multiflori has nourishing the blood and yin, the detoxicating functions that dispels the wind, and decocting liquid all has inhibitory action to multiple pathogenic bacteria, cures mainly blood deficiency Light-headedness, the hepatic and renal YIN deficiency, chronic malaria body void, rubella pruritus, carbuncle sore scrofula; Radix Trichosanthis has the function of clearing away heat and promoting production of body fluid, detumescence and apocenosis, and trichosanthin has immunostimulation simultaneously and suppresses two kinds of functions, and nuclease is arranged, and is a kind of albumen with broad-spectrum disease resistance toxic action, cures mainly lung-heat type cough, sore swollen toxin; Rhizoma Chuanxiong has blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping effect, controls a wind cutting, all gas, long-pending, all blood of all labor, cures mainly wind and cold temperature numbness, dizzy, the ulcer sores of headache; Radix Angelicae Sinensis have enrich blood, invigorate blood circulation, moisturize, the effect of laxation, cure mainly asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, human body numbness, ulcer sores; Fructus Cnidii has the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, and extract has the effect of very strong antifungal, virus, infusorian, cures mainly scrotum pruritus due to damp pathogen, rheumatic arthralgia, eczema scabies; Radix Achyranthis Bidentatae has invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow effect, and decoct has analgesic and anti-inflammatory effects, cures mainly soreness of waist and knee joint, carbuncle malignant boil, cold-damp flaccidity syndrome and arthralgia syndrome; Drying damp and strengthening spleen, wind-damp dispelling effect that Rhizoma Atractylodis have cures mainly the spleen and stomach being stranded by dampness, asthenia drowsiness, damp-edema, arthromyodynia domination of damp pathogen; Rhizoma Acori Graminei has waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, the sharp numbness effect of dispeling the wind, and leachate has inhibitory action to common property fungus, cures mainly rheumatic arthralgia, carbuncle scabies; Radix Glycyrrhizae has the effect of QI invigorating invigorating middle warmer, relieving spasm to stop pain, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription, cures mainly asthenia lack of appetite, leanness yellowish complexion, carbuncle pyogenic infections from tumour or sore.In prescription, each pharmaceutically active ingredient is integrated, play altogether heat clearing and damp drying, removing blood stasis dispel the wind, draw out pus by applying a plaster to the affected part collapse itch, the removing obstruction in the collateral to relieve pain effect, treating both the principal and secondary aspects of a disease is effectively cured psoriasis, and does not recur, and lichen planus, vitiligo, stupid wind agriopsoria are had significant curative effect.Shenxian capsulea nd preparation technology adopts fine powder medicine and many medicine thick pastes to granulate and adorns capsule, and preparation technology is easy, low production cost, convenient oral.

Shenxian capsulea nd cures mainly the test of relevant main pharmacodynamics with function and has confirmed significant curative effect in preclinical study, and recommends Coming-of-Age Day oral dose 3 times on the one, one time 4.

The invention has the beneficial effects as follows: the scientific formulation novelty, the prescription medication is imitated complementary, preparation technology is easy, low production cost, convenient oral, have heat clearing and damp drying, removing blood stasis dispel the wind, draw out pus by applying a plaster to the affected part collapse itch, removing obstruction in the collateral to relieve pain, nourishing the liver and kidney, nourishing blood and promoting blood circulation effect, can effectively cure dissimilar psoriasises, and do not recur, and lichen planus, vitiligo, wind and tinea are had significant curative effect.

Specific embodiments:

1, the Shenxian capsulea nd prescription by ten simply Chinese herbal medicine form, wherein Radix Sophorae Flavescentis 120 gram, Radix Clematidis 120 grams, Radix Polygoni Multiflori 100 grams, Radix Trichosanthis 80 grams, Rhizoma Chuanxiong 80 grams, Radix Angelicae Sinensis 80 grams, Fructus Cnidii 120 grams, Radix Achyranthis Bidentatae 100 grams, Rhizoma Atractylodis 80 grams, Rhizoma Acori Graminei 100 grams, Radix Glycyrrhizae 80 grams, get crude drug remove impurity well sifted respectively by existing tcm and herbal slice standard before the preparation after weighing standby.

2, Shenxian capsulea nd preparation technology:

1. getting Rhizoma Acori Graminei pulverized 80 mesh sieves and becomes the fine powder medicine standby.

2. getting Radix Sophorae Flavescentis, Radix Trichosanthis, Radix Polygoni Multiflori, Radix Clematidis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Glycyrrhizae adds 10 times of water gagings and decocts for the first time, decocted 1.5 hours, after getting Rhizoma Atractylodis again and being soaked in water 2 hours, add to fry in shallow oil and add 6 times of water gagings decoctions in the slag for the second time, decocted 1 hour, merge twice decoction liquor and filter, it is that 1.28-1.30 (60 ℃) thick paste is standby that filtrate is concentrated into relative density.

3. with thick paste and standby fine powder medicine mixing, 60 ℃ of temperature are dried, and powder becomes fine powder, makes soft material with an amount of ethanol, cross 14 order nylon mesh and granulate, and 60 ℃ of temperature are dried into the granule medicine.

4. the granule medicine is sub-packed in and gets patent medicine in 1000 No. 0 capsules.

Claims (2)

1, a kind of Shenxian capsulea nd, it is characterized in that: the crude drug total amount is 1060 grams in the prescription, is made up of Radix Sophorae Flavescentis 120 grams, Radix Clematidis 120 grams, Radix Polygoni Multiflori 100 grams, Radix Trichosanthis 80 grams, Rhizoma Chuanxiong 80 grams, Radix Angelicae Sinensis 80 grams, Fructus Cnidii 120 grams, Radix Achyranthis Bidentatae 100 grams, Rhizoma Atractylodis 80 grams, Rhizoma Acori Graminei 100 grams, Radix Glycyrrhizae 80 grams.

2, Shenxian capsulea nd preparation technology according to claim 1, it is characterized in that: get Rhizoma Acori Graminei earlier and pulverized 80 mesh sieves and be mixed into the fine powder medicine, get Radix Sophorae Flavescentis again, Radix Trichosanthis, Radix Polygoni Multiflori, Radix Clematidis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Glycyrrhizae nine flavor Chinese herbal medicine add 10 times of water gagings and decoct for the first time, decocted 1.5 hours, filter, the Rhizoma Atractylodis immersion was added 6 times of water gagings with filtering medicinal residues after 2 hours, decoct once more for the second time, decocted 1 hour, and filtered, merge twice and decoct filtrate, it is 1.28-1.30 (60 ℃) thick paste that filtrate is concentrated into relative density, with fine powder medicine mixing, to granulate, No. 0 capsule of packing into gets patent medicine.