CN1683386A - Method for extracting vitexin, use and preparation - Google Patents
Method for extracting vitexin, use and preparation Download PDFInfo
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- CN1683386A CN1683386A CN 200510038041 CN200510038041A CN1683386A CN 1683386 A CN1683386 A CN 1683386A CN 200510038041 CN200510038041 CN 200510038041 CN 200510038041 A CN200510038041 A CN 200510038041A CN 1683386 A CN1683386 A CN 1683386A
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- vitexin
- product
- crude extract
- howthorn leaf
- howthorn
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Abstract
The present invention discloses the extraction process of vitexin and the extraction process includes the following steps: obtaining coarse haw leaf extract, hydrolyzing the coarse haw leaf extract in water solution of strong acid, separating crystal, and re-crystallization to obtain the product vitexin. The vitexin product has purity over 98%, and may be used in preparing instilment liquid, freeze dried powder, tablet, capsule or dripping pill applied in the treatment of cardiac vascular diseases, including coronary heart disease, myocardial infarction and angina pectoris.
Description
Technical field
The invention belongs to effective components of Chinese medicinal, specifically the extracting method of Vitexin, purposes and preparation in the Howthorn Leaf.
Background technology
Hawthorn is a kind of herbal medicine commonly used, and in the existing history of more than one thousand years of China, Folium Crataegi extract is made tablet, based on mouth with, but lack by scientific process, purifying process, composition mixes, content differs, with using the post-absorption degree varies, dosage is difficult to grasp, and curative effect is affected.
Summary of the invention
The extracting method, purposes and the preparation that the purpose of this invention is to provide a kind of Howthorn Leaf effective ingredient Vitexin obtain highly purified Vitexin monomer, make the vein medicine and mouthful use administration, treat cardiovascular disordeies such as coronary heart disease, myocardial infarction, stenocardia clinically.
Technical scheme of the present invention is as follows:
A kind of extracting method of Vitexin obtains the crude extract of Howthorn Leaf earlier, it is characterized in that the crude extract hydrolysis in the aqueous solution under highly acid condition with Howthorn Leaf, separate out crystallization after, carry out recrystallization again, obtain the target product Vitexin.
Described strong acidic condition is meant that the PH of the aqueous solution is 0.1～1.5.
The crude extract of described Howthorn Leaf carries out the product of extraction using alcohol again for after Howthorn Leaf water is carried.
The crude extract of described Howthorn Leaf is that the water of hawthorn is carried product or extraction using alcohol product.
The purposes of Vitexin is characterized in that being applied to cardiovascular disorder coronary heart disease, myocardial infarction, anginal treatment.
The preparation of Vitexin is characterized in that it being small acicula driping liquid, lyophilized powder, reaches tablet, capsule or pill.
Preparation of the present invention is extracted, separates, makes with extra care and got by the single medicinal material Howthorn Leaf.The Vitexin purity of carrying reaches more than 98%, makes intravenous fluid and oral preparations again.Prove that through experimentation on animals this product can increase the volume of blood flow of coronary artery and cardiac muscle, reduces the cardiovascular blood resistance of penetrating, reduce blood viscosity, improve the RBC deformability and suppress thrombosis, ischemia myocardial damage is had good protective action.The clinical diseases such as coronary heart disease, myocardial infarction, stenocardia that are used for the treatment of, effect is remarkable.
Embodiment
The extraction of Vitexin:
1, with Howthorn Leaf boiling 1～3 time, 6～12 times of amount of water.
2, collecting decoction is concentrated into fluid extract, medicinal material: medicinal extract liquid weight ratio=1～3: 1～3: 1.
3, add ethanol and precipitate, leave standstill a few hours hypsokinesis and pour out pure liquid, adding amount of alcohol is 2～6 times, and the time is 12～36 hours.
4, decompression recycling ethanol is condensed into fluid extract.
5, above-mentioned fluid extract is added in the entry, and add hydrochloric acid, water transfer solution PH=0.6～1 is hydrolyzed.
6, with hydrating solution refrigeration 3～6 days, separate out crystallization.Refrigerating temperature=0～10 ℃.
7, get crystallization, carry out recrystallization with ethanol.
8, the Vitexin that obtains is made little liquid drugs injection injection liquid, lyophilized powder and tablet, capsule, pill.
9, the various preparations that made by Vitexin are applied to coronary heart disease, myocardial infarction, stenocardia clinically.
Claims (6)
1, a kind of extracting method of Vitexin obtains the crude extract of Howthorn Leaf earlier, it is characterized in that the crude extract hydrolysis in the aqueous solution under highly acid condition with Howthorn Leaf, separate out crystallization after, carry out recrystallization again, obtain the target product Vitexin.
2, method according to claim 1 is characterized in that described strong acidic condition is meant that the PH of the aqueous solution is 0.1～1.5.
3, method according to claim 1, the crude extract that it is characterized in that described Howthorn Leaf carries out the product of extraction using alcohol again for after Howthorn Leaf water is carried.
4, method according to claim 1, the crude extract that it is characterized in that described Howthorn Leaf are that the water of hawthorn is carried product or extraction using alcohol product.
5, the purposes of Vitexin is characterized in that being applied to cardiovascular disorder coronary heart disease, myocardial infarction, anginal treatment.
6, the preparation of Vitexin is characterized in that it being small acicula driping liquid, lyophilized powder, reaches tablet, capsule or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510038041 CN1300164C (en) | 2005-03-06 | 2005-03-06 | Method for extracting vitexin, use and preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510038041 CN1300164C (en) | 2005-03-06 | 2005-03-06 | Method for extracting vitexin, use and preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1683386A true CN1683386A (en) | 2005-10-19 |
| CN1300164C CN1300164C (en) | 2007-02-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510038041 Active CN1300164C (en) | 2005-03-06 | 2005-03-06 | Method for extracting vitexin, use and preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1300164C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100473658C (en) * | 2006-08-09 | 2009-04-01 | 江苏省中国科学院植物研究所 | Method of extracting and purifying sphenomeris chinensis orientin and vitexin |
| EP2417976A1 (en) * | 2009-04-10 | 2012-02-15 | Fuji-Sangyo Co., Ltd. | Process for production of orally ingestible composition containing arabinosyl vitexin, and use of the composition |
| CN107721992A (en) * | 2017-09-08 | 2018-02-23 | 东北林业大学 | A kind of method for being converted from sorbic acid wastewater and separating Vitexin |
-
2005
- 2005-03-06 CN CN 200510038041 patent/CN1300164C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100473658C (en) * | 2006-08-09 | 2009-04-01 | 江苏省中国科学院植物研究所 | Method of extracting and purifying sphenomeris chinensis orientin and vitexin |
| EP2417976A1 (en) * | 2009-04-10 | 2012-02-15 | Fuji-Sangyo Co., Ltd. | Process for production of orally ingestible composition containing arabinosyl vitexin, and use of the composition |
| CN102387806A (en) * | 2009-04-10 | 2012-03-21 | 富士产业株式会社 | Process for production of orally ingestible composition containing arabinosyl vitexin, and use of the composition |
| EP2417976A4 (en) * | 2009-04-10 | 2013-05-01 | Fuji Sangyo Co Ltd | Process for production of orally ingestible composition containing arabinosyl vitexin, and use of the composition |
| CN107721992A (en) * | 2017-09-08 | 2018-02-23 | 东北林业大学 | A kind of method for being converted from sorbic acid wastewater and separating Vitexin |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1300164C (en) | 2007-02-14 |
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| PB01 | Publication | ||
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| C14 | Grant of patent or utility model | ||
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Effective date of registration: 20170809 Address after: 236800 Bozhou Economic Development Zone, Anhui Patentee after: ANHUI JIUFANG PHARMACEUTICAL CO., LTD. Address before: 230088 No. 624, Mount Huangshan Road, Hefei, Anhui Patentee before: Hefei Qixing Medical Technology Co., Ltd. |
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| TR01 | Transfer of patent right |