CN1679691A - Medicine for treating encephalatrophy and preparation thereof - Google Patents
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Abstract
A Chinese medicine for treating encephalocele is prepared from 6 Chinese-medicinal materials including hispid fig, fortune euonymus stem, red ginseng, rehmannia root, etc. Its advantage is high cure rate.
Description
The present invention relates to medicine (Fructus Alpiniae Oxyphyllae health brain ball) of a kind of brain atrophy and preparation method thereof, belong to the field of Chinese medicines.
Brain atrophy is a kind of encephalopathy with the pathological change name, how finger human body cerebral tissue structural volume is dwindled, the cell number minimizing also has slight gliosis and cerebral arteries degeneration in various degree, be a kind of chronic progressive disease, mainly show as hypomnesis, emotional lability, ability of thinking goes down, attention can not be concentrated, and develops into dementia when serious, loses to intelligence eventually to be its Clinical symptoms.Primary disease is mainly in the patient more than 50 years old, and the course of disease can exceed surplus several years even 10 year, and the women is more than the male.
Syndrome in TCM has been controlled (1) deficiency of kidney-essence, and the hollow card of brain: [method of treatment] replenishing kidney-essence, marrow is filled out in Fructus Alpiniae Oxyphyllae.The medicinal Bolus as a Kidney-Yin-Tonic plus-minus in side: Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae, Poria, the Cortex Eucommiae, Semen Cuscutae, Colla cornus cervi, Colla Plastri Testudinis, Fructus Lycii, Rhizoma Acori Graminei, Radix Polygalae, Fructus Alpiniae Oxyphyllae (2) kidney yang deficiency, brain lose the replenishing vital QI with drugs of warm nature card: [method of treatment] temperature male wind-supplying kidney, nourishing the brain and improving intelligence.The medicinal Yougui Wan, the kidney-Yang-Reinforcing Bolus plus-minus in side: Radix Rehmanniae Preparata, Rhizoma Dioscoreae, mountain cornel, the Cortex Eucommiae, Fructus Lycii, Semen Cuscutae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Colla cornus cervi, Radix Angelicae Sinensis, Rhizoma Acori Graminei, Radix Polygalae.(3) hepatic and renal YIN deficiency, syndrome of upper hyperactivity of liver yang: [method of treatment] suppressing the hyperactive liver and subsiding YANG, promoting blood circulation to remove obstruction in the collateral.Medicinal TIANMA GOUTENG YIN in side or Zhengan Xifeng Tang plus-minus: Radix Paeoniae Alba, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Concha Margaritifera, Concha Haliotidis, Radix Salviae Miltiorrhizae, Pollen Tyjphae, Rhizoma Chuanxiong, Herba Leonuri, Pheretima, Scorpio, Fructus Crataegi, SHENGLONGMU.(4) the turbid heap soil or fertilizer over and around the roots of expectorant is contained, and brain key card is covered in resistance: the expectorant of [method of treatment] dissipating depression of QI, change turbid refreshment.The medicinal WEIDANTANG plus-minus in side: Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Fructus Aurantii Immaturus, Rhizoma Acori Graminei, Radix Polygalae, Radix Curcumae, Semen Sinapis Albae, Radix Glycyrrhizae.(5) syndrome of blood stasis blocking brain: [method of treatment] blood circulation promoting and blood stasis dispelling, collateral dredging is had one's ideas straightened out.Medicinal TONGQIAOHUOXUE Decoction in side or decoction for removing blood stasis plus-minus: Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, the Radix Rehmanniae, Radix Bupleuri, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Radix Et Rhizoma Rhei, the Radix Astragali, Rhizoma Polygonati, Rhizoma Acori Graminei.(6) deficiency of qi and blood card: [method of treatment] benefiting QI and nourishing blood, nourishing the brain and improving intelligence.The medicinal BAZHEN TANG plus-minus in side: Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Rehmanniae, the Radix Paeoniae Alba, the Radix Astragali, Fructus Alpiniae Oxyphyllae, Fructus Rubi, the Cortex Eucommiae.Have than positive effect.
Western medical treatment does not still have the effectively preventing measure at present to primary disease.Medicine haloperidol commonly used, antidepressants etc.
Encephalopathy, much more particularly cerebrovascular disease is the property in the China and even the world, multiple disease, to see in the city, is listed as human No.1 disease with cardiovascular disease, researching and developing out low toxicity, efficient, multi-functional medicine, is ailing patient and household, friend's long-cherished wish.Therefore, people better treat the spleen kidney deficiency to curative effect, and essence and blood loses empty, forgetful giddy, and the asthenia lack of appetite, diseases such as soreness of the waist and knees are the eager demand of Chinese medicine preparation of the brain atrophy of doctor trained in Western medicine.By retrieval, up to now, also do not find the report of any relevant pharmaceutical composition of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, finally found the treatment of better curative effect spleen kidney deficiency has been arranged, essence and blood loses empty, forgetful giddy, the asthenia lack of appetite, diseases such as soreness of the waist and knees are the oral medicinal herb medicine of doctor trained in Western medicine brain atrophy, the market sale feedback has confirmed unique curative effect of this medicine, thereby has finished the present invention.
The object of the invention just provides a kind of Chinese medicine composition of more effectively treating brain atrophy.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
Medicament selection Herba Fici Simplicissimae of the present invention, Caulis Seu Folium Euonymi Fortunei, Millettia Speciosa, Radix Flemingiae Philippinensis, Radix Ginseng Rubra, Radix Rehmanniae Preparata, Herba Cistanches, Fructus Corni, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Notoginseng, Rhizoma Cimicifugae, Radix Glycyrrhizae make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat (brain atrophy) spleen kidney deficiency, essence and blood loses empty, forgetful giddy, the asthenia lack of appetite, diseases such as soreness of the waist and knees.Wherein select dementia (be the brain atrophy of the doctor trained in Western medicine) etiology and pathogenesis of Fructus Alpiniae Oxyphyllae health brain ball for use according to theory of Chinese medical science: primary disease many because of the people to old, get weaker physically, deficiency of spleen and stomach, asthenia of essence and blood is due to the brains inanition.Lid " Ling Shu Miraculous Pivot or Divine Axis sea opinion " is said: " the brain being the reservoir of the marrow ", " excess of marrow-reservoir, the then light many power of strength are crossed its degree certainly; Deficiency of marrow-reservoir is vertigo and tinnitus then, soreness of waist dizziness, and order does not have finding, slack peacefully sleeping." " Lei Zheng Zhi Cai " think: " and brain is a supreme mental palace, the sea of clear marrow, and the institute of real memory is with also." Wang Qingren " correction of the errors of medical works theory of human brain " thinks: " the sudden inspiration memory is at brain "; " high year no memory person, gradually sky is also for brains.So ", theory of Chinese medical science thinks that brain is a supreme mental palace, is nourished by brains, the brains abundance could be spirited clear clever; Deficiency of marrow-reservoir, then refreshing stupidity is blunt, loses spirit clearly.Traditional Chinese medical science ancient books still has the record of " brains disappear "." disappearing " is meant consumption, and disappear " brains disappear " drilled again and caused slow-witted, stupid, stupid all diseases.This is like similar to cerebral malacia, the brain atrophy disease of modern medicine.From the above, dementia is a mental diseases, and its sick position is at brain, but sudden inspiration, and memory and brains have the ten minutes confidential relation, also with visceral dysfunction such as the heart spleen kidney substantial connection is arranged.Lid the kidney generating marrow and dominating bone and leading in brain, old people, deficiency of kidney-essence, brains lose and fill, refreshing machine out of control and confuse slow-witted, clumsy in one's movement, delay of response; Spleen injury, the strong mistake department that transports, the source of generating QI and blood deficiency, deficiency of qi and blood, the damage of essence insufficiency of blood is difficult to fill in brain,
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have better curative effect in the following weight parts scope:
Herba Fici Simplicissimae 5-10 part, Caulis Seu Folium Euonymi Fortunei 2-4 part, Millettia Speciosa 2-5 part, Radix Flemingiae Philippinensis 2-10 part, Radix Ginseng Rubra 1-3 part, Radix Rehmanniae Preparata 3-5 part, Herba Cistanches 2-3 part, Fructus Corni 1-4 part, Radix Angelicae Sinensis 1-4 part, Cortex Cinnamomi 0.33-1.5 part, Radix Notoginseng 1-3 part, Rhizoma Cimicifugae 1-3 part, Radix Glycyrrhizae 0.5-3 part.
Be preferably: 5 parts of Herba Fici Simplicissimae, 3 parts of Caulis Seu Folium Euonymi Fortuneis, 2.6 parts of Millettia Speciosa, 2.6 parts of Radix Flemingiae Philippinensiss, 3 parts of Radix Ginseng Rubra, 3 parts of Radix Rehmanniae Preparata, 3 parts of Herba Cistanches, 1.8 parts of Fructus Corni, 1.6 parts of Radix Angelicae Sinensis, 0.66 part of Cortex Cinnamomi, 1 part of Radix Notoginseng, 1 part of Rhizoma Cimicifugae, 1.8 parts in Radix Glycyrrhizae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.For example these crude drugs can be made powder through pulverizing takes after mixing it with water; Can be with these crude drug decoctings, the condensed water decocting liquid is taken by decoction then; Can become concentrated pill to take through water concentration contraction these crude drugs, also can explore and make other preparations, but for each raw material that makes this medicine is brought into play drug effect better, preferably above-mentioned 13 kinds of crude drugs are carried out water concentration the groping of technology of contracting with orthogonal experiment, preferably, the preparation method of medicine activity component of the present invention is as follows:
A. 1 part of 3 parts of 5 parts of Herba Fici Simplicissimae, Radix Ginseng Rubra, Radix Notoginseng, the Cortex Cinnamomi with described weight proportion is ground into fine powder for 0.66 part, and be standby;
B. 3 parts of Caulis Seu Folium Euonymi Fortuneis, 2.6 parts of Millettia Speciosa, 2.6 parts of Radix Flemingiae Philippinensiss, 3 parts of Radix Rehmanniae Preparata, 3 parts of Herba Cistanches, 1.8 parts of Fructus Corni, 1.6 parts of Radix Angelicae Sinensis, 1 part of Rhizoma Cimicifugae, 1.8 part of 9 flavor of Radix Glycyrrhizae medical material decoct with water three times by weight ratio, each amount of water was not advisable to have powder, merge three times decocting liquid, filter, filtrate is concentrated into the thick paste of relative density 1.30 ~ 1.35 (70 ℃);
C. b gained thick paste is mixed with a gained fine powder, drying is ground into fine powder.
D. will add refined honey in the c gained fine powder, mixing, pill promptly gets and concentrates big honeyed pills.
Medicine activity component of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as pill, powder, decoction, granule etc.
Medicine of the present invention has invigorating the kidney and spleen, and functions such as creating the marrow and invigorating the brain are used for the spleen kidney deficiency, and essence and blood loses empty, forgetful giddy, and the asthenia lack of appetite, diseases such as soreness of the waist and knees are the brain atrophy of doctor trained in Western medicine.
(testing data 1) Fructus Alpiniae Oxyphyllae health brain ball cures mainly relevant Pharmacodynamic test of active extract data with function
Summary: obstacle is consolidated in mice that Fructus Alpiniae Oxyphyllae health brain ball causes the one-sided common carotid artery of ligation and rat memory the improvement effect; The mouse memory acquired disturbance that Camphor tree willow alkali is caused has certain antagonism; The mice balanced capacity reduction that the one-sided common carotid artery of ligation is caused has certain improvement effect; To heavily not influence of cutaneous horn, this product still has certain sedation.
Fructus Alpiniae Oxyphyllae health brain ball system is by the Chinese medicine preparation of Guangxi Qiang Shou Pharmaceutical Group Co., Ltd's development, be used for the treatment of brain atrophy, clinical plan daily dose is 43.6g crude drug/day, be grown up for 9 ball/days, we are subjected to the trust of Guangxi Qiang Shou Pharmaceutical Group Co., Ltd, this product is carried out the test of pesticide effectiveness, Test Summary is as follows:
Experiment purpose:, cause animal brain ischemic damage in learning and memory and disequilibrium pathological model and other test method by reducing the blood supply of brain.Observe this product therapeutical effect and other pharmacological actions, for the medication of clinical treatment brain atrophy provides reference to brain atrophy (vascular dementia).
Be subjected to the reagent thing: Fructus Alpiniae Oxyphyllae health brain ball (we use it to extract the dried cream of intelligence) lot number is 980928, and the dried cream of every gram is equivalent to total medical material 7.4 grams.Provide by Guangxi Qiang Shou Pharmaceutical Group Co., Ltd.Time spent, be diluted to the suspension of institute's arm concentration with water.Each group dispensing volume is equated.Used dosage all refers to " gram medical material/kg " in the literary composition.
Animal: SD rat and NIH white mice, Chinese medicine institute animal housing provides by Guangxi, by the sex sub-cage rearing. 6 in every cage.Feed the standard particle feedstuff, 25+3 ℃ of experiment room temperature, relative humidity 70 soil 5%.
Test method is selected: brain atrophy is one of reason of senile dementia.Majority is because the cerebrovascular function obstacle causes brain blood supply deficiency, due to the malnutrition.Mainly show as the imbalance of the obstacle and the body equilibrium function of memory function.Therefore, our reference literature
[1], method. and improvement a little, cause rat and mouse brain blood for empty not enough one-sided common carotid artery ligation, cause learning and memory, equilibrium function imbalance (being equivalent to vascular dementia), with diving tower method, maze method
[2]With the balancer method
[3](improvement slightly) detects memory function and the equilibrium function of animal respectively; With Camphor tree willow alkali blocking-up brain M one choline energy function of nervous system, observe the influence that this product obtains memory.With autonomic activities and pentobarbital sodium hypnosis test, observe the sedation of this product.
Main test method: see " test method and result " for details
The animals administer reaction: each dosage treated animal is not seen the abnormal response relevant with drug toxicity at duration of test, and each test index all adopts quantitative target.
Dosage is provided with and medication: according to document
[4]And trial test. Fructus Alpiniae Oxyphyllae health brain ball white mice is established 25.9g/kg/d, 12.95g/kg/d, 6.48g/kg/d (be equivalent to respectively clinical daily dose 43.5g/60kg/d 35.6,17.8,8.9 times), and rat is established 12.95g/kg/d, 6.48g/kg/d, 3.24g/kg/d (be equivalent to respectively clinical daily dose 17.8,8.9,4.4 times); Piracetam (positive control drug) is 0.3g/kg/d (rat, mice is together); Diazepam (positive control drug) is 2.5mg/kg.Be gastric infusion, the rat oral gavage volume is the 1ml/100g body weight, and mice is the 0.2ml/10g body weight.
Experimental control: the model contrast is established in the learning and memory test, and intact animal's contrast and positive drug contrast are established in positive drug contrast and intact animal's contrast, calm test.This test adopts the common carotid artery ligation to cause the blood supply in brain deficiency, and cerebral disorder is checked learning and memory in rats and mice with maze method then.Document
(1)Only introduce pathological model, and do not have medicine, we are according to pharmacological action (the learning capacity decline due to the tool opposing anoxia etc. of piracetam.Improve cerebral circulation. promote the brain of damage to recover. strengthen ability of learning and memory.Be mainly used in treatment memory and thought disturbance, for decline in old age, cerebrovascular accident, the dysmnesia that cerebral trauma causes all have certain curative effect). it is elected to be the positive control drug of test model.
Test method and result: 1, rat aorta disordered brain function test (vascular dementia): select normal health ♂ rat for use. body weight 250-280g. is under pentobarbital sodium 40mg/kg ip anesthesia. carry out the permanent ligation of right common carotid artery. 10 days wound healings of postoperative. with the rat random packet of survival, per 10. totally 5 groups.If model control group, piracetam (positive drug) 0.3g/kg/d group, Fructus Alpiniae Oxyphyllae health brain ball 12.95g/kg/d group, 6.48g/kg/d group, 3.24g/kg/d group.Other gets 10 of normal ♂ SD rat (not operation) as intact animal's matched group.Each administration treated animal accept every day gastric infusion once, continuous 35 days, last administration 1 hour had " Y " type labyrinth.Train each treated animal debating not to light (place of safety) signal.Stimulate with alternating current 30-50V. train 10 times.Each clockwise direction changes the position, place of safety.Second day again administration obtain situation with the memory that method detects each animal after one hour, write down the errors number of every animal to place of safety identification, and with errors number the animal below 2 times as remembering animal up to standard.Number of animals up to standard respectively organized in record.And model control group is relatively. with the significance of errors number difference between t value method check group. use corrected X
2The significance of number of animals difference up to standard between method check group.
As a result, the animal number average up to standard of each administration group and normal control group is more than model control group, has only that difference has remarkable meaning between small dose group and the model control group; The errors number of each administration group all is less than model control group, has only the difference between normal control group and the model control group to have remarkable meaning.Prompting, this product has the trend (table 1) of facilitation to the recovery of impaired rat brain function.
Table 1 Fructus Alpiniae Oxyphyllae health brain ball is to the influence of rat brain functional rehabilitation
| Group | Dosage (g/kg) | Number of animals | Remember animal up to standard | Errors number |
| Normal control model contrast piracetam Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball | ????- ????- ????0.30 ????12.95 ????6.48 ????3.24 | ????10 ????10 ????10 ????10 ????10 ????10 | ????6 ????2 ????4 ????6 ????6 ????8* | ??2.1±1.2* ??4.3±2.5 ??2.9±1.9 ??2.8±2.0 ??2.4±2.7 ??2.4±2.3 |
*P＜0.05
2, mice vascular disordered brain function test is selected normal health ♂ NIH mice for use, body weight 25-28g.Under pentobarbital sodium 50mg/kg ip anesthesia, carry out the permanent ligation of right common carotid artery.Postoperative began grouping, 15 every group in 24 hours.If model control group, piracetam (positive drug) 0.3g/kg/d group, Fructus Alpiniae Oxyphyllae health brain ball 25.90g/kg/d, 12.95g/kg/d, 6.48g/kg/d group.Other gets 10 of normal ♂ NIH white mice (not operation) as the normal control group.Each administration treated animal is accepted to irritate stomach and cheat medicine 1 time every day, continuous 16 days, administration in the 15th day after 1 hour, trains each treated animal distinguishing the place of safety with the diving tower method.Stimulate with alternating current 36v.Trained 10 minutes.After 24 hours, be administered once, after 1 hour, each Mus is put into the place of safety of diving tower device, observe each animal in 5 minutes from the place of safety (valve rubber) down to the number of times (errors number) of electric grid and record from putting into the place of safety to time (error latence) of making a mistake for the first time and mistake generation number of animals.With observation animal learning capacitation.Trained back 72 hours, and detected the errors number of each treated animal with method, error latence and the wrong number of animals of each group are consolidated ability with the memory of observation animal.Compare with model control group, with the error latence and the errors number significance of difference between t value method or reference differential technique check group; Use corrected X
2The significance of wrong number of animals difference between method check group.
The influence that table 2 Fructus Alpiniae Oxyphyllae health brain ball recovers cerebral functions of mice
| Group | Dosage (g/kg) | Error latence (second) | Errors number | The mistake number of animals | |||
| Instructed back 1 day | Instructed back 3 days | Instructed back 1 day | Instructed back 3 days | Instructed back 1 day | Instructed back 3 days | ||
| Normal control model contrast piracetam Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball | ??- ??- ??0.30 ??25.90 ??12.95 ??6.48 | ??285±33 ??217±102 ??286±50* ??296±14* ??254±87 ??257±96 | ??260±97 ??148±89 ??213±120 ??232±106* ??214±118 ??242±104* | ?0.2±0.4° ??1.3±1.9 ?0.1±0.3° ??0.1±0.3° ??0.8±1.4° ??0.6±1.8° | ??0.1±0.3° ????5.0±6.1 ??3.2±5.3 ??1.9±3.4 ??1.5±3.0 ??1.3±2.9° | ?2/10 ?6/13 ?1/13 ?1/12 ?4/11 ?2/11 | ?1/10Δ ??11/13 ?5/13Δ ??4/12Δ ??5/11 ?3/10Δ |
* P＜0.05 (t value method). Δ P＜0.05 (corrected X
2Method), P＞0.05 (reference differential technique)
As a result, train in back 24 hours observation indexs, the error latence of organizing except that Fructus Alpiniae Oxyphyllae health brain ball 25.90g/kg/d group and piracetam 0.3g/kg/d, is significantly than the model group leader.The equal nonsignificance of the group difference of errors number and wrong number of animals.Prompting, this model obtains influence little (table 2) to the memory of mice.But in the index of training observation in back 72 hours, the error latence of Fructus Alpiniae Oxyphyllae health brain ball 25.90g/kg/g group and 6.48g/kg/d group,, the mistake number of animals was obviously lacked than model control group significantly than model group leader, and difference has the significance meaning; Although and errors number is also lacked than model group, the difference nonsignificance.Prompting, this product are consolidated the memory of impaired mice certain facilitation, helps forgetful recovery (table 2).
3, Camphor tree willow alkali brings out the test of cerebral functions of mice obstacle, chooses normal NIH white mice ♂, ♀ half and half, 10 every group.If normal control group, model control group, piracetam (positive drug) 0.30g/kg matched group.Fructus Alpiniae Oxyphyllae health brain ball 25.90g/kg/d, 12.95g/kg/d, the 6.48g/kg/d group, each administration treated animal is accepted gastric infusion once every day.Continuous 14 days.After the last administration 1 hour, except that the normal control group, ip Camphor tree willow alkali 10mg/kg, after 10 minutes mice put into the diving tower device, train 10 minutes (method with test 2) after 24 hours, be administered once again, measure diving tower errors number in the mice 5 minutes with method after 1 hour, the wrong number of animals of error latence and each group is estimated the memory acquisition disturbance effect that medicine antagonism Camphor tree willow alkali brings out.Compare with model control group.With errors number between t value method check group and error latence difference significance, with the significance of wrong number of animals difference between direct probability method check group.
As a result, the error latence of Fructus Alpiniae Oxyphyllae health brain ball 12.95g/kg group,, the errors number of 12.95g/kg group and 6.48g/kg group was lacked than model control group than model group leader, but had only the difference between 6.48g/kg group and the model group to have the significance meaning; 12.95g/kg the wrong animal of group and 6.48g/kg group is imitated and lacks than model group, but has only the difference between 12.95g/kg group and the model control group to have remarkable meaning.Prompting, the memory acquisition disturbance that this product is brought out the Camphor tree willow has antagonism (table 3).
Table 3 Fructus Alpiniae Oxyphyllae health brain ball brings out the sound of mouse memory acquired disturbance to Camphor tree willow alkali
| Group | Dosage (g/kg) | Error latence | Errors number | The mistake number of animals |
| Normal control model contrast piracetam Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball | ????- ????- ????0.30 ????25.90 ????12.95 ????6.48 | ????259.6±13.9* ????147.9±56.1 ????242.0±85.2* ????104.5±88.9 ????182.9±121.9 ????137.0±111.0 | ??0.4±0.7* ??5.7±2.5 ??0.8±0.9* ??6.0±6.0 ??3.0±3.6 ??2.6±2.8* | ??3/10Δ ????10/10 ??5/10Δ ????10/10 ??6/10Δ ????8/10 |
* t value method is proofreaied and correct in P＜0.05, compares with model group) Δ P＜0.05 (directly the probability method compares with model group)
4, brain injury mice equilibrant test: choose normal health ♂ NIH white mice.Body weight 25-28g carries out the right common carotid artery ligation under pentobarbital sodium 50mg/kg ip anesthesia.Wood grouping in back 24 hours, 15 every group.If model control group, piracetam (positive drug) 0.3g/kg/d matched group, health brain ball 25.90g/kg/d, 12.95g/kg/d, 6.48g/kg/d group.Each administration group is accepted gastric infusion once every day, continuous 15 days.After the last administration 1 hour, it was on the 0.8cm horizontal glass rod that mice is placed on a diameter.If mice falls, immediately it to be put back on the glass rod, record adds up mice drop number on glass rod in 1 minute, then, the full brain taking-up of each Mus is weighed.Compare with model group.With drop number and the different significance of the cutaneous horn method of double differences between t value method check group.
As a result, the drop number of health brain ball 25.90g/kg/d group significantly is less than model control group.Prompting, this product has the trend (table 4) of facilitation to the recovery of brain injury mice equilibrant, and the face cutaneous horn does not heavily have significant change (table 5).
Table 4 Fructus Alpiniae Oxyphyllae health brain ball is to the influence of brain injury mice equilibrant
| Group | Dosage (g/kg) | Number of animals | Drop number | The P value |
| Model contrast piracetam Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball | ????- ????0.30 ????25.90 ????12.95 ????6.48 | ????13 ????13 ????12 ????11 ????10 | ????6.3±2.9 ????4.4±3.5 ????3.7±3.1 ????7.4±3.1 ????6.2±2.3 | ????＞0.05 ????＜0.05 ????＞0.05 ????＞0.05 |
Table 5 Fructus Alpiniae Oxyphyllae health brain ball soaks heavy influence to the full brain of brain injury white mice
| Group | Dosage (g/kg) | Cutaneous horn heavy (mg) | The P value |
| Model contrast piracetam Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball | ????- ????0.30 ????25.90 ????12.95 ????6.48 | ????519±103 ????519±83 ????533±83 ????523±91 ????533±92 | ????＞0.05 ????＞0.05 ????＞0.05 ????＞0.05 |
5, mice autonomic activities test: select normal health NIH mice ♂ ♀ half and half for use, 10 every group.If the normal control group, diazepam 2.5mg/kg group, Fructus Alpiniae Oxyphyllae health brain ball 25.90g/kg, 12.95g/kg, 6.48g/kg group.Behind gastric infusion of each administration group 1 hour, mice is put into the lucite groove of one 30 * 20 * 20cm, mice is praised the number of times of forelimb in the observed and recorded 2 minutes in groove, as the index of mice autonomic activities.To organizing relatively, check the significance of group difference with normally with t value method.
The movable number of times of the brain of Fructus Alpiniae Oxyphyllae health as a result, ball 12.95g/kg and 6.48g/kg group significantly reduces than normal control group.Prompting, this product have the mice autonomic activities effect (table 6) of inhibition
Table 6 Fructus Alpiniae Oxyphyllae health brain ball is to the influence of mice autonomic activities
| Group | Dosage (g/kg) | Movable number of times | The P value |
| Model contrast diazepam Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball | ??- ??2.5mg ??25.90 ??1?2.95 ??6.48 | ??16.4±5.7 ??1.4±1.9 ??8.8±12.3 ??8.2±6.8 ??3.6±3.9 | ????＜0.05 ????＞0.05 ????＜0.05 ????＜0.05 |
6, pentobarbital sodium hypnosis test: select normal health NIH mice ♂ ♀ half and half for use, 10 every group.If the normal control group, diazepam 2.5mg/kg group, Fructus Alpiniae Oxyphyllae health brain ball 25.9g/kg, 12.95g/kg, 6.48g/kg group.Behind gastric infusion of each administration group 1 hour, lumbar injection pentobarbital sodium 30mg/kg, observe righting reflex loss in 15 minutes then and reach number of animals more than 1 minute, as sleeping number of animals.Compare with the normal control group, with proofreading and correct x
2The significance of method check group difference.
As a result, the sleeping animal number average of Fructus Alpiniae Oxyphyllae health brain ball 25.9g/kg and 12.95g/kg group is more than the normal control group, but the difference nonsignificance.Prompting this product has certain synergistic trend (table 7) to the syngignoscism of pentobarbital sodium.
Table 7 Fructus Alpiniae Oxyphyllae health brain ball is to the influence of pentobarbital sodium syngignoscism
| Group | Dosage (g/kg) | Sleeping number of animals | The P value |
| Normal control diazepam Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball Fructus Alpiniae Oxyphyllae health brain ball | ??- ??2.5mg ??25.90 ??12.95 ??6.48 | ????1/10 ????9/10 ????4/10 ????2/10 ????1/10 | ????＜0.05 ????＞0.05 ????＞0.05 ????＞0.05 |
Conclusion: this product is to the under-supply memory acquisition disturbance that brings out of brain blood, and memory acquisition disturbance that obstacle and the bulky alkali of Camphor tree the brings out trend that all has some improvement is consolidated in memory.The under-supply equilibrant decline that causes also has some improvement to brain blood, also has certain sedation.
(testing data 2) Fructus Alpiniae Oxyphyllae health brain pill for curing asthenia of both the spleen and kidney is demonstrate,proved dull-witted clinical observation and is summed up
First Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, second Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, The People's Hospital, Guangxi Zhuang Autonomous Region
Fructus Alpiniae Oxyphyllae health brain ball is the experience of Guangxi Qiang Shou Pharmaceutical Group Co., Ltd's root a tree name Guangxi Zhuang Autonomous Region ethnic groups and the ethnic drug preparation of traditional Chinese medical theory and experience development, has invigorating the kidney and spleen, the effect of creating the marrow and invigorating the brain.Be used for deficiency of spleen and stomach, the dementia due to the brains inanition, the brain atrophy of modern medicine see above-mentioned patient also available it.In order to verify its effect, according to " provisions for new drugs approval "
[1]" new Chinese medicine clinical research guideline "
[2]First Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi (120 example), second Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi (90 example) and The People's Hospital, Guangxi Zhuang Autonomous Region's (90 example) in June, 1999 to 1999 year December Fructus Alpiniae Oxyphyllae health brain ball has been carried out clinical observation, the result is summarized as follows:
One, test objective: investigate Fructus Alpiniae Oxyphyllae health brain ball to the dull-witted clinical efficacy of asthenia of both the spleen and kidney card and to the safety of human body.
Two, case diagnosis standard
(1) tcm diagnosis standard (with reference to nineteen ninety Gerontological Society of All-China Association of Traditional Chinese Medicine tentative standard):
1, memory: memory ability comprises that the ability of nearly thing of memory and thing far away weakens.
2, judge: judge that cognitive personage, article, time, place ability go down.
3, calculate: calculate numeral, state digital ability and go down.
4, identification: identification space position and structural capacity go down.
5, language: oracy comprises the ability obstacle of understanding others' linguistic competence and answering a question systematically.The person of having a high degree of literacy reads, the writing ability obstacle.
6, individual character: disposition is unsociable and eccentric, apathetic expression, and language is wordy to be repeated, selfish narrow, obstinate stubborn, or groundless is glad, is easy to excitement or rage etc.
7, thinking: abstract thinking ability descends, and for example can not explain proverb, the identical point that can not distinguish word and difference, can not give a definition to things etc.
8, personality: character trait changes, and moral ethics lacks, and is shameless.
9, the age: be more common in person more than 60 years old.
10, the course of disease: the onset slower development, the course of disease is long.
(2) Chinese medical discrimination asthenia of both the spleen and kidney card: except that above main symptom, with the asthenia sialorrhea, extremities being not warm, indigestion and loss of appetite weak, the abdominal distention loose stool, light red tongue is fat, white, slippery and moist fur, deep and weak pulse is unable.
(3) Western medicine diagnose standard: (with reference to the nineteen eighty-three DSM--M of American Psychiatric Association standard):
1, the hypophrenia causes influences society and vocational activity.
2, dysmnesia.
3, in following 41 is arranged:
(1) abstract thinking ability obstacle:, can not give a definition to things etc. as not explaining proverb, the identical point that can not distinguish word and difference.
(2) disturbance in judgement.
(3) other senior function of cortex obstacles: as aphasia, apraxia, agnosia, structure apraxia.
(4) personality changes: the originally change of character trait or reinforcement.
4, unconscious obstacle.
5, there be one of following:
(1) discovery that medical history, body are looked into, lab testing has the prompting cause of disease.
(2) as there not being above-mentioned evidence, and behavior change belongs to multiple recognition function obstacle, can reasonably get rid of functional psychosis, can be with regard to its organic diseases because of making certain deduction.
Three, case choice criteria:
(1) include standard in:
1, meet in the dementia, the Western medicine diagnose standard.
2, the head CT inspection has the cortex atrophy and the ventricles of the brain to enlarge change.
3, Chinese medical discrimination belongs to the asthenia of both the spleen and kidney card.
(2) exclusion standard:
1, the age is at under-18s or more than 80 years old, gestation or women breast-feeding their children, allergic constitution or to this medicine allergy sufferers.
2, be associated with serious primary disease such as cardiovascular, liver, kidney and hemopoietic system, psychotic.
3, do not meet the standard of including in, the end is medication in accordance with regulations, can't judge that curative effect or data are not congruent to affect the treatment or safety judgement person.
Four, observational technique: adopt district's group at random, contrast, non-blind method observe.
1, grouping; Observe 300 examples altogether, treatment group and matched group were in 8: 4 and 3: 3 ratio district group random packet.
2, the consumption course of treatment and medication.
(1) treatment group: Fructus Alpiniae Oxyphyllae health brain ball, oral, each 3 balls, every day 3 times.
(2) matched group: Piracetam Tablet [Tianjin Jinshi Pharmaceutical Co., Ltd. produces, and the accurate word (1995) of medicine is defended No. 002686 in Tianjin], oral, each 3, every day 3 times.
(3) course of treatment: 4 weeks.
(4) viewing duration is treated this medicine without other.
Five, observation index
1, safety observation:
(1) general health check-up project.
(2) blood, urine, just routine examination.
(3) heart, liver, kidney function test.
2, health giving quality observation:
(1) intelligence changes.
(2) personality changes.
(3) self care ability.
(4) whole body performance: can position, gait, defecation automatic control etc.
(5) tcm syndrome changes.
Six, witness light and heavy degree grade scale:
1, dysnoesia:
2 minutes: slowness of thinking, but thinking is clear substantially, and language is still clear, and memory, judgment, computing power have decline slightly.
4 minutes: bradykinesia, be weak of understanding, often the language fails to express the meaning for language, and it is often incorrect to answer a question, and memory, judgment, computing power obviously descend.
6 minutes: apathy, language performance and faculty of understanding extreme difference were often given an irrelevant answer, and obstacles such as aphasia, apraxia, agnosia are very arranged
2, disorientation;
2 minutes: orientation force slightly went down.
4 minutes: orientation force obviously went down.
6 minutes: unorientation.
3, personality disorder: 6 minutes: the personality characteristic change is arranged, and moral ethics lacks, and is shameless etc.
4, comprehensive function;
2 minutes: life was taken care of oneself substantially, and diet, clothing, washing etc. partly need the people to look after, and still can carry out the mass society activity.
4 minutes: life can not be taken care of oneself substantially, and most people of need such as diet, clothing, washing are looked after, and can not carry out the mass society activity.
6 minutes: diet, clothing, washing and defecation etc. all can not be taken care of oneself partly needed the people to look after.
5, fatigue and weakness:
2 minutes: lassitude, can adhere to physical work.
4 minutes: spirit was tired, can adhere to routine work reluctantly.
6 minutes: spirit was extremely tired, can not adhere to daily routines.
6, sialorrhea:
2 minutes: sialorrhea was light, and amount is few, and idol has generation.
4 minutes: sialorrhea was more very measured morely, and generation is arranged.
6 minutes: sialorrhea was heavy, and amount is many, took place repeatedly.
7, extremities being not warm:
2 minutes: brothers felt cold.
4 minutes: cold extremities.
6 minutes: go cold all over, get warm not understanding.
8, indigestion and loss of appetite:
2 minutes: poor appetite, appetite reduced 1/3.
4 minutes: inappetence, appetite reduced 1/3-2/3.
6 minutes: appetite was poor, and appetite reduces more than 2/3.
9, abdominal distention:
2 minutes: abdominal distention was light, did not alleviate at short notice.
4 minutes: abdominal distention was not understood more in a long time.
6 minutes: abdominal distention all day.
10, loose stool:
2 minutes: The stool is completely mashed was shapeless, every day 1-2 time.
4 minutes: The stool is completely mashed was shapeless, and every day is more than 3 times, or stool in the pasty state, every day 1-2 time.
6 minutes: defecate in the pasty state, every day was more than 10 times, or stool is rare water sample, every day 1-2 time.
Seven, efficacy assessment standard:
1, clinic control.Cardinal symptom is recovered normally substantially, and is directed sound, and it is correct to answer a question, and takes care of oneself, and can recover the mass society activity.
2, produce effects; Cardinal symptom is most of recovers normal, and orientation is sound substantially, and answering a question is in the main true, and reaction is general, and life can be taken care of oneself.
3, effective; Main mental symptom alleviates to some extent or partly disappears, and life is taken care of oneself substantially, and answering a question is in the main true, but reaction is still blunt, and intelligence and personality still have obstacle.
4, invalid, do not reach above standard person.
Eight, statistical procedures; Ranked data Ridit analytic process.Enumeration data X
2Method of inspection.Measurement data t method of inspection.
The result
One, physical data: among the 300 routine qualified experimenters, 200 examples are organized in treatment, matched group 100 examples.
Two, two groups of comparabilities are checked:
1, two groups of sex ratios are:
Table 1 liang group sex (example) is (X relatively
2Check)
| The example number | The man | The woman | |
| Treatment group matched group | ??200 ??100 | ??132 ??64 | ??68 ??36 |
Annotate: treatment group and matched group sex ratio, X
2=0.12, P＞0.05, there was no significant difference.
2, two groups of age ratios are:
The table 2 liang group age (year) relatively (Ridit analysis)
| The example number | ?～27 | ?～37 | ?～47 | ??～57 | ??～58 | |
| Treatment group matched group | 200 100 | ??2 ??1 | ??6 ??6 | ??9 ??5 | ??11 ??8 | ??172 ??80 |
Annotate: treatment group and matched group age ratio, U=0.86, P＞0.05, difference does not have the significance meaning.
3, two groups of courses of disease are relatively:
The table 3 liang group course of disease (my god) relatively (Ridit analysis)
| The example number | ～3 years | ～5 years | ～6 years | |
| Treatment group matched group | ??200 ??100 | ??105 ??56 | ??61 ??30 | ??34 ??14 |
Annotate: two groups of courses of disease compare, U=0.61, and P＞0.05, difference does not have the significance meaning.
4, total mark compares before the treatment:
(the X ± SD) comparison (t check) of total mark before table 4 treatment
| The example number | Integration before the treatment | |
| Treatment group matched group | ??200 ??100 | ????26.04±9.42 ????25.82±9.52 |
Annotate: total mark compares U:0.19, P＞0.05 before two groups of treatments.Difference does not have the significance meaning.
Comparability detects and shows before the above-mentioned treatment, two groups before sex, age, the course of disease, treatment the state of an illness etc. relatively, difference there are no significant meaning.The principal element that prompting influences two groups of prognosis has harmony.
Three, curative effect is relatively:
1, treatment back clinical symptoms curative effect is relatively:
Table 6 treatment back clinical symptoms curative effect is (Ridit analysis) relatively
| The example number | Improve 3 grades | Improve 2 grades | Improve 1 grade | There is not the level of improvement | ||
| Dysnoesia | Treatment group matched group | 200 95 | ????4 ????3 | ????59 ????26 | ????89 ????42 | ????48 ????24 |
| Disorientation | Treatment group matched group | 180 87 | ????15 ????13 | ????49 ????16 | ????73 ????31 | ????43 ????27 |
| Personality disorder | Treatment group matched group | 87 39 | ????19 ????12 | ????17 ????6 | ????26 ????9 | ????25 ????12 |
| Comprehensive function | Treatment group matched group | 200 100 | ????22 ????8 | ????50 ????23 | ????88 ????48 | ????40 ????21 |
| Fatigue and weakness | Treatment group matched group | 195 90 | ????36 ????19 | ????56 ????24 | ????64 ????30 | ????39 ????17 |
| Sialorrhea | Treatment group matched group | 132 72 | ????24 ????16 | ????29 ????11 | ????30 ????25 | ????49 ????20 |
| Extremities being not warm | Treatment group matched group | 156 73 | ????30 ????17 | ????43 ????21 | ????54 ????23 | ????29 ????12 |
| Indigestion and loss of appetite | Treatment group matched group | 186 79 | ????34 ????15 | ????54 ????24 | ????57 ????24 | ????41 ????16 |
| Abdominal distention | Treatment group matched group | 157 71 | ????37 ????14 | ????39 ????28 | ????46 ????21 | ????35 ????8 |
| The loose stool | Treatment group matched group | 131 58 | ????35 ????17 | ????33 ????15 | ????31 ????16 | ????32 ????10 |
Attention: after various symptoms, the sign treatment, all have clear improvement, P＜0.01, difference has the significance meaning.But treatment group and matched group are relatively, P all＞0.05, the difference nonsignificance.
2, total effects is relatively:
Table 5 total effects is (Ridit analysis) relatively
| The example number | Control (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effectively (%) | |
| Treatment group matched group | 200 100 | ????24(12.0) ????11(11.0) | ??36(18.0) ??19(19.0) | ??104(52.0) ??53(53.0) | ??36(18.0) ??17(17.0) | ??164(82.0) ??83(83.0) |
Annotate: treatment group and matched group total effects compare, U:0.06, P＞0.05.Difference does not have the significance meaning.
Four, security inspection
1, treatment group:
(1) routine blood test: detected 200 examples before the treatment, wherein, there is no unusual in the 189 example treatment back checks of normal range.
(2) routine urinalysis: detected 200 examples before the treatment, wherein, there is no unusual in the 195 example treatment back checks of normal range.
(3) fecal occult blood: detected 200 examples before the treatment, wherein, there is no unusual in the 196 example treatment back checks of normal range.
(4) electrocardiogram: detected 200 examples before the treatment, wherein, there is no unusual in the 200 example treatment back checks of normal range.
(5) ALT: detected 200 examples before the treatment, wherein, there is no unusual in the 186 example treatment back checks of normal range.
(6) BCr: detected 200 examples before the treatment, wherein, there is no unusual in the 186 example treatment back checks of normal range.
(7) BUN: detected 200 examples before the treatment, wherein, there is no unusual in the 184 example treatment back checks of normal range.
2, matched group;
(1) routine blood test: detected 100 examples before the treatment, wherein, there is no unusual in the 91 example treatment back checks of normal range.
(2) routine urinalysis: detected 100 examples before the treatment, wherein, there is no unusual in the 98 example treatment back checks of normal range.
(3) fecal occult blood: detected 100 examples before the treatment, wherein, there is no unusual in the 98 example treatment back checks of normal range.
(4) electrocardiogram: detected 100 examples before the treatment, wherein, there is no unusual in the 76 example treatment back checks of normal range.
(5) ALT: detected 100 examples before the treatment, wherein, there is no unusual in the 100 example treatment back checks of normal range.
(6) BCr: detected 100 examples before the treatment, wherein, there is no unusual in the 92 example treatment back checks of normal range.
(7) BUN: detected 100 examples before the treatment, wherein, there is no unusual in the 92 example treatment back checks of normal range.
Five, untoward reaction is observed; The untoward reaction symptom does not all appear after two groups of medications.
Six, discussion and conclusion
1, treatment group clinic control, obvious effective rate, effective percentage are respectively 12%, 18%, 52%, and total effective rate is 82%; Matched group clinic control, obvious effective rate, effective percentage are respectively 11%, 19%, 53%, and total effective rate is 83%.Treatment group and matched group relatively do not have significance.Prompting Fructus Alpiniae Oxyphyllae health brain ball has clinical efficacy preferably to asthenia of both the spleen and kidney card dementia, and is similar to the contrast medicine.
2, the clinical symptoms efficacy result shows, all has clear improvement behind the various symptom treatments.But two groups relatively, and difference does not have the significance meaning.Prompting Fructus Alpiniae Oxyphyllae health brain ball can obviously improve the dull-witted clinical symptoms of asthenia of both the spleen and kidney card, and is similar to the contrast medicine.
3, this research to 200 routine patients carried out blood, just conventional shuttle is looked into, the heart, liver, kidney function test are not all found obvious adverse reaction and toxic and side effects.Prompting this product is clinical safe and reliable.
[embodiment 1] is with above 13 flavor medicines, Herba Fici Simplicissimae, Radix Ginseng Rubra, Radix Notoginseng, Cortex Cinnamomi powder are broken into fine powder, nine flavors such as all the other Caulis Seu Folium Euonymi Fortuneis, decoct with water three times (adding 8,6,6 times in water), each 2 hours, collecting decoction filtered, filtrate is concentrated into the clear paste of close relatively 1.30-1.35 (70 ℃), adds above-mentioned fine powder.Drying is ground into fine powder, and mixing adds refined honey and makes concentrated honeyed pill, promptly.
Claims (5)
1, a kind of medicine that dementia is the doctor trained in Western medicine brain atrophy (Fructus Alpiniae Oxyphyllae health brain ball) for the treatment of is characterized in that it mainly is to be made by the crude drug of following weight portion: Herba Fici Simplicissimae 5-10 part, Caulis Seu Folium Euonymi Fortunei 2-4 part, Millettia Speciosa 2-5 part, Radix Flemingiae Philippinensis 2-10 part, Radix Ginseng Rubra 1-3 part, Radix Rehmanniae Preparata 3-5 part, Herba Cistanches 2-3 part, Fructus Corni 1-4 part, Radix Angelicae Sinensis 1-4 part, Cortex Cinnamomi 0.33-1.5 part, Radix Notoginseng 1-3 part, Rhizoma Cimicifugae 1-3 part, Radix Glycyrrhizae 0.5-3 part.
2, according to the medicine of claim 1, wherein the preferred consumption of crude drug is: 5 parts of Herba Fici Simplicissimae, 3 parts of Caulis Seu Folium Euonymi Fortuneis, 2.6 parts of Millettia Speciosa, 2.6 parts of Radix Flemingiae Philippinensiss, 3 parts of Radix Ginseng Rubra, 3 parts of Radix Rehmanniae Preparata, 3 parts of Herba Cistanches, 1.8 parts of Fructus Corni, 1.6 parts of Radix Angelicae Sinensis, 0.66 part of Cortex Cinnamomi, 1 part of Radix Notoginseng, 1 part of Rhizoma Cimicifugae, 1.8 parts in Radix Glycyrrhizae.
3, the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
A. 1 part of 3 parts of 5 parts of Herba Fici Simplicissimae, Radix Ginseng Rubra, the Radix Notoginseng, the Cortex Cinnamomi that take by weighing weight proportion are ground into fine powder for 0.66 part, and be standby;
B. Caulis Seu Folium Euonymi Fortunei, Millettia Speciosa, Radix Flemingiae Philippinensis, Radix Rehmanniae Preparata, Herba Cistanches, Fructus Corni, Radix Angelicae Sinensis, Rhizoma Cimicifugae, the Radix Glycyrrhizae 9 flavor medical materials with described weight proportion decoct with water three times, each amount of water was not advisable to have powder, merge three times decocting liquid, filter, filtrate is concentrated into the thick paste of relative density 1.30 ~ 1.35 (70 ℃);
C. b gained thick paste is mixed with a gained fine powder, drying is ground into fine powder.
4, the preparation method of the described medicine of claim 3, the active component that makes adds refined honey, mixing, pill promptly gets and concentrates big honeyed pills.
5, preparation method according to claim 3 is 120 orders at the step a) smashing fineness wherein; B) in medicine is decocted with water when extracting, add 8 times of amounts of water for the first time, decocted 2 hours, add 6 times of amounts of water for the second time, decocted 2 hours, add 6 times of amounts of water for the third time, decocted 2 hours.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105935423A (en) * | 2016-06-24 | 2016-09-14 | 广西中医药大学 | Zhuang drug for treating dementia |
| JP2020117494A (en) * | 2019-01-23 | 2020-08-06 | 広西中医薬大学 | Bouxcuengh pharmaceutical composition for blood supplementation and method for preparing the same |
| CN113754677A (en) * | 2021-08-18 | 2021-12-07 | 厦门大学 | Novel coumarin dimer and preparation method and application thereof |
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2005
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105935423A (en) * | 2016-06-24 | 2016-09-14 | 广西中医药大学 | Zhuang drug for treating dementia |
| JP2020117494A (en) * | 2019-01-23 | 2020-08-06 | 広西中医薬大学 | Bouxcuengh pharmaceutical composition for blood supplementation and method for preparing the same |
| CN113754677A (en) * | 2021-08-18 | 2021-12-07 | 厦门大学 | Novel coumarin dimer and preparation method and application thereof |
| CN113754677B (en) * | 2021-08-18 | 2022-09-20 | 厦门大学 | Novel coumarin dimer and preparation method and application thereof |
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