CN1679588A

CN1679588A - Medicinal composition for treating mimic tic

Info

Publication number: CN1679588A
Application number: CN 200510002686
Authority: CN
Inventors: 李来道
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-01-26
Filing date: 2005-01-26
Publication date: 2005-10-12

Abstract

A composite medicine for treating facial spasm is proportionally prepared from lidocaine, anisodamine and diazepam. Its advantages are high curative effect and low by-effect.

Description

A kind of pharmaceutical composition for the treatment of facial spasm

Technical field

The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition that facial muscle are twitched for the treatment of.

Background technology

Facial spasm is department of neurology commonly encountered diseases, frequently-occurring disease, shows that mainly the histrionic muscles that nervus facialis is arranged be can't help, irregular, painless paroxysmal is twitched, and the cause of disease is not fully aware of at present.At present, this disease is not had well-content Therapeutic Method both at home and abroad, adopt medication effect poor, the time is slow; And adopt the modus operandi risk bigger.As, CN1052158's the prosopalgic scheme of Drug therapy of " a kind of pure Chinese medicine trident loose and preparing process " was disclosed on the Chinese patent communique May 10 in 2000, it has adopted 10 Chinese herbal medicine to be made into the traditional Chinese medicine mouth treatment nervi trigeminus of taking medicine by a certain percentage, not only dose is big, the time cycle is long, and the cost height.For this reason, " treating the preparation method of prosopalgic compositions and fumigant " of a kind of CN1490024 disclosed on April 21st, 2004, the fumigant of being made by Flos Carthami, Herba Schizonepetae, Radix Saposhnikoviae and Herba speranskiae tuberculatae directly acts on face area, and this method is safer, but is difficult in radical cure in a short time.

Summary of the invention

In order to address the above problem, the purpose of this invention is to provide a kind of instant effect, treatment cycle weak point, cure rate than higher a kind of pharmaceutical composition for the treatment of facial spasm.

The object of the present invention is achieved like this: a kind of pharmaceutical composition for the treatment of facial spasm, constitute by lignocaine, Anisodamine and stable component, with the Anisodamine volume parts is benchmark, wherein the capacity of each composition is: 1% lignocaine: 10% Anisodamine: 10% is stable, according to 5～10: 1～2: 8 preparations.

Compound method of the present invention is after the lignocaine that will be purchased is 1% with the pump pickle diluted concentration, to prepare according to above-mentioned capacity with 10% Anisodamine again, is expelled on patient's the focus with 10% diazepam solution respectively to get final product.In above-mentioned composition, the content of 1% lignocaine is preferably 5ml, 10% stable 8ml, 10% Anisodamine 1ml.

Because the present invention has adopted said composition to inject, not only can remove vasospasm, alleviate compressing stimulation, the elimination risk factor of abnormal vascular to nervus facialis, and the effect of lignocaine and stabile nerve anesthesia, behind the nervus facialis dry injection, can make excitement, the conductivity of nervus facialis be suppressed and block, thereby eliminate the control of facial spasm outbreak.In addition, stabile of flaccid muscles, calm, angst resistance effect also helps the control of facial spasm outbreak.Compound method of the present invention is simple, and is evident in efficacy, and the effect of paying is little, and treatment is a kind of ideal injection liquid for the treatment of the intractable primary mimic tic extensively.

The specific embodiment

Below in conjunction with embodiment the present invention is further specified.

Embodiment 1

Is to get 5ml after 1% with the lignocaine that is purchased with the pump pickle diluted concentration, prepares with 10% Anisodamine 1ml, standby; With the sharp leading edge of the sick side breast of patient is point of puncture, and behind the routine disinfection skin, it is subcutaneous to use medical No. seven injection needles to thrust, and proceeds inserting needle to mastoid process root leading edge then, and the fold mid point is an entry point before the also optional ear-lobe, seeks nervus facialis at 2.5～3cm place and does.When nervus facialis is done in the thorn, slight distending pain sense is arranged and can bring out or increase the weight of facial spasm, after confirming accurately, mixed liquor slowly be expelled to patient's focus on according to 5: 1 volume parts 1% standby lignocaine 5ml and 10% Anisodamine 1ml, observed 6 minutes, after the facial paralysis symptom occurring, inject 10% stable 8ml.Also can inject ethanol or vitamin B1 or B12 in right amount.Pulling out sterilizes behind the pin gets final product.Treatment time is a shot every other day, till facial spasm stops fully, and general treatment 2～5 times.

Embodiment 2

Is to get 10ml after 1% with the lignocaine that is purchased with the pump pickle diluted concentration, prepares with 10% Anisodamine 2ml, standby.Acies before the sick side breast of patient point is sought nervus facialis and is done, and when nervus facialis in the acupuncture is done, slight distending pain sense is arranged, and can bring out or increase the weight of facial spasm; After the affirmation, 1% standby lignocaine 10ml and 10% Anisodamine 2ml mixed liquor slowly are expelled on the focus, observed 5 minutes, the facial paralysis symptom appears and after, inject 10% stable 8ml.Inject once every other day, till facial spasm stops fully.

Through the treatment, the tic complete obiteration and in half a year not the recidivist for the recovery from illness; The canthus or the corners of the mouth have slight tic and persistent period relatively to lack, and are produce effects; Duration of seizure and persistent period obviously reduce, for taking a turn for the better; No obvious alleviator before and after the treatment is for invalid.Since 1986, treat facial spasm disease 7600 many cases with this ruling by law, primary mimic tic patient 731 examples were controlled in twice extraction successively in 1994 and 2002, man's 350 examples, woman's 381 examples, the age, obtaining total effective rate was 99.3% at 24～75 years old, cure rate keeps not more than 93.4%, 3 year relapse rate is 73.7%.

See Table 1,731 routine patients are carried out two groups of therapeutic outcome statistical dispositions: one group of treatment group that the pharmaceutical composition that is employing the present invention prepares is treated the patient; Another group adopts the matched group with the common drug treatment, and two groups differ highly significant, and the effect of treatment group is better than matched group.

See Table 2, the patient in 3 years carries out observation of curative effect to 328 routine facial spasm, handles by statistics, and two groups have evident difference, and treatment group long-term effect is better than matched group.

Claims

1, a kind of pharmaceutical composition for the treatment of facial spasm, it is characterized in that: this medicaments injection stable is mixed respectively by 1% lignocaine and 10% Anisodamine and 10%, and wherein the Capacity Ratio of each composition is: 1% lignocaine: 10% Anisodamine: 10% stabile mixed liquor is 5～10: 1～2: 8.

2, a kind of pharmaceutical composition for the treatment of facial spasm according to claim 1, it is characterized in that: described medicaments injection stable is mixed respectively by 1% lignocaine and 10% Anisodamine and 10%, and wherein the Capacity Ratio of each composition is: 1% lignocaine: 10% Anisodamine: 10% stabile mixed liquor is 5: 1: 8.