CN1672581A - Making process of food for fast biologically conversion of lipid, blood sugar, ketobodies, amines and phenol - Google Patents
Making process of food for fast biologically conversion of lipid, blood sugar, ketobodies, amines and phenol Download PDFInfo
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- CN1672581A CN1672581A CNA2004100398458A CN200410039845A CN1672581A CN 1672581 A CN1672581 A CN 1672581A CN A2004100398458 A CNA2004100398458 A CN A2004100398458A CN 200410039845 A CN200410039845 A CN 200410039845A CN 1672581 A CN1672581 A CN 1672581A
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Abstract
The present invention is food developed based on the principle that galacturonic acid from plant material can combine with fatty acid, cholesterol, glucose, acetoacetic acid, phenol, etc. to produce water soluble non-toxic galacturonic glycoside exhausted with urine. Experiment shows that the food can convert fat, blood sugar, ketones, amines and phenol biologically, reduce weight fast, restore normal blood fat, blood pressure, blood sugar, and ketones. Therefore, the food of the present invention may be used in preventing and treating obesity, fatty liver, atherosclerosis, cerebral hemorrhage, phenol poisoning, etc.
Description
The technological process of preparing food for fast biotransformation of lipid, blood sugar, ketone body, amine and phenol is a biochemical technology developed comprehensively based on the biological function of galacturonic acid in sunflower disc combining fatty acid, cholesterol, glucose, acetoacetic acid, β -hydroxybutyric acid, putrescine, cadaverine, histamine, tyramine, tryptamine and phenol to produce water soluble and non-toxic galacturonic acid glycoside and fast eliminated with urine.
In the background art, hyperlipidemia, hypertension, atherosclerosis, fatty liver, obesity, cerebral hemorrhage, cerebral thrombosis and diabetes are always the key research subjects in the medical field. At present, various medicines for reducing blood fat, blood pressure, blood sugar and ketone bodies have advanced preparation technology and obvious treatment effect, but cannot achieve the effects of fundamentally preventing the formation of diseases and enabling patients to thoroughly get rid of the medicines to recover health.
Disclosure of Invention
Mechanism (a)
The sunflower disk contains rich D-galacturonic acid, the D-galacturonic acid molecules are combined by α -1.4 glycosidic bonds to form linear polymer with molecular weight of 30 ten thousand, which is one of the main components of plant mucilage.
The polymerized D-galacturonic acid macromolecules are catalyzed and hydrolyzed by α -1.4 glycosidase from pancreas on small intestinal mucosa, α -1.4 glycosidic bonds are broken to generate monomolecular D-galacturonic acid which is diffused into blood, enters the liver through portal vein, enters liver microsome cells and participates in liver biotransformation reaction.
D-galacturonic acid is a strongly polar substance. The substances which are obtained through oxidation, reduction and hydrolysis in the first-phase biotransformation reaction and have polarity groups but insufficient polarity and still can not be fully dissociated in water are subjected to a combination reaction to generate substances which have strong polarity, large dissociation degree in water, are nontoxic and are easy to be discharged out of a body along with urine.
The uronic acid binding reaction is the most common reaction in the second phase of hepatic biotransformation compounds containing polar groups such as alcohol, phenol, thiophenol, amine and carboxyl groups can be used as thesubstrate for this binding reaction, and the product of the reaction is β -galacturonide, either ether or ester.
The substances causing hyperlipidemia, hypertension, atherosclerosis, fatty liver, obesity, cerebral hemorrhage and cerebral thrombosis are triacylglycerol, cholesterol and fatty acid, the substances causing diabetes are glucose, the substances causing ketonemia and ketonuria are acetoacetic acid and β -hydroxybutyric acid, the substances causing amine poisoning are putrescine, cadaverine, histamine, tyramine and tryptamine, and the substances causing phenol poisoning are tyramine and phenol.
The hemiacetal hydroxyl group on the molecule of the D-galacturonic acid is very active and can be dehydrated and condensed with polar groups on each molecule of fatty acid, cholesterol, glucose, acetoacetic acid, β -hydroxybutyric acid, putrescine, cadaverine, histamine, tyramine, tryptamine and phenol to generate galacturonic acid glycoside.
Obviously, triacylglycerol is a core substance causing hyperlipidemia, hypertension, atherosclerosis, fatty liver, obesity, cerebral hemorrhage, cerebral thrombosis and diabetes, so the key point for solving the way of triacylglycerol is the problem. Triacylglycerols are fat-soluble substances, are fat-storage forms, are insoluble in water, and 98% of fatty tissues are triacylglycerols. When the body undergoes fat mobilization, triacylglycerols are catalytically hydrolyzed by lipases, releasing fatty acids and glycerol. However, fat in adipose tissue is not easily mobilized because the body first chooses to use glucose oxidation to supply energy when exogenous glucose is available, and can only use the fat oxidation in adipose tissue to supply energy when the body is in order to meet the energy demand when the exogenous glucose is cut off. The first function of a fast bioconversion food is to mobilize fat out of the depot.
The main components of the fast bioconversion food are D-galacturonic acid polymer and water. Since there is little glucose, after eating for over ten hours, various glycogen stored in the body is substantially consumed. To meet energy requirements, fat mobilization in adipose tissue is accelerated and enhanced. Triacylglycerols stored in adipose tissue are hydrolyzed under the catalysis of hormone-sensitive lipases, releasing fatty acids and glycerol. The fatty acid diffuses into blood and combines with albumin to form polar particles which are easily dissolved in water, and the polar particles are rapidly transported throughout the whole body for each tissue to take and utilize, and are oxidized to supply energy. The speed of conveying and renewing the fatty acid is quite high, and only 4-6 minutes are needed from the completion of fat mobilization to the completion of the oxidation of the fatty acid to generate carbon dioxide and water in all tissues of the whole body, and about 25 grams of the fatty acid can be renewed every hour. When the body is lack of glucose resources, the body mainly relies on oxidized fat to provide energy, which accounts for more than 80% of the energy required. About 9 kcal/g of energy can be released by oxidizing 1 g of fat, about 4 kcal of energy released by the oxidation of protein and about 4 kcal of energy released by the oxidation of glucose generated from gluconeogenesis, and about 17 kcal of energy is mobilized in total, so that the requirements of physiological activities can be met.
If the concentration of the fatty acid in the blood plasma is too high and the fatty acid cannot be discharged in time, diseases such as hyperlipidemia, hypertension, atherosclerosis, fatty liver, obesity, cerebral hemorrhage, cerebralthrombosis and the like can be caused. The free carboxyl (-COOH) group on the fatty acid molecule is a polar group and can be dehydrated and condensed with D-galacturonic acid.
2. The total cholesterol amount of human body is about 2 g per kilogram of body weight. Cholesterol in the body is mainly derived from animal food and liver synthesis. Cholesterol is not oxidized completely to carbon dioxide and water in the body, but instead forms a wide variety of steroid species, such as VD3Cholic acid, androgens, estrogen, progestins, corticoids, and the like. The amount of bile acid salts synthesized by the liver from oxidation of cholesterol per day is about half of the total amount of cholesterol metabolism. If the plasma cholesterol concentration exceeds the upper limit of normal, hyperlipidemia, atherosclerosis, cerebral thrombosis and fatty liver may be caused.
The free hydroxyl (-OH) group at the 3-carbon of the cholesterol molecule is a polar group.
3. "glucose in blood, also called blood sugar, is the form of transport of sugar in the body. Blood glucose concentrations in excess of 120 mg% are termed hyperglycemia. Diabetes occurs when blood glucose concentrations exceed the renal threshold of 160-180 mg%. Hyperglycemia and diabetes are primarily found in diabetes. "
"the structure of the monosaccharide is polyhydroxy aldehyde and polyhydroxy ketone, and thus has the properties of alcoholic hydroxyl group and carbonyl group, such as ester formation, ether formation, acetal formation reaction and the like with alcoholic hydroxyl group. The hemiacetal hydroxyl group on the glucose molecule is very reactive and many important properties of sugars are associated with it. Monosaccharides are polyols that, when reacted with acids, form esters. Furthermore, the esterification reaction of carboxylic acid and alcohol "D-galacturonic acid belongs to sugar acid, and can be condensed with hydroxyl group on the hemiacetal of glucose molecule to form ester by dehydration.
The glucose molecule contains hemiacetal hydroxyl (-OH) groups which are polar groups.
4. The main reason for the occurrence of ketosis is that fat is mobilized in large quantity, and the fatty acid can be completely oxidized in tissues such as cardiac muscle, skeletal muscle, brain and the like to generate carbon dioxide and water and release about 9 kcal/g of energy, but the fatty acid is not completely oxidized in liver to generate intermediate products such as small molecular acetoacetic acid, β -hydroxybutyric acid, acetone and the like, which are collectively called ketone bodies.
Normally, only a small amount of ketone bodies (about 0.8-5 mg/100 ml) are present in human blood, but in hunger and diabetes, the amount of ketone bodies synthesized by the liver increases due to increased fat mobilization, when the concentration of ketone bodies released into the blood exceeds 70 mg/100 ml, the ketone bodies are beyond the ability of extrahepatic tissues to utilize the ketone bodies by oxidation, ketosis and ketonuria are caused, and the acetoacetic acid and β -hydroxybutyric acid contain free carboxyl groups (-COOH), which are acidic substances, so that the pH of the blood is reduced when the concentration in the blood is too high, and acidosis is caused.
Experiments prove that the ketone body accumulation phenomenon does not occur, because the food does not contain glucose and exogenous glucose, which is equal to the reduction of a large energy supply resource, the organism can only supply energy by only depending on oxidized fatty acid and ketone body, and the generation amount of the fatty acid and the ketone body and the utilization capacity of extrahepatic tissues are in dynamic equilibrium, so the ketone body accumulation does not occur.
The concentrations of blood sugar, blood fat and ketone body of the diabetic are all seriously over standard. Experiments prove that: after a large amount of food is eaten, the concentrations of blood sugar, ketone bodies and blood fat are all reduced in about 7 days.
The free carboxyl groups (-COOH) on the acetoacetic and β -hydroxybutyric acid molecules are polar groups.
5. Diabetics have to allay their hunger with protein in order to control the rise in blood glucose concentration. Protein is also one of the energy sources. Approximately 4 kcal of energy can be released per gram of protein oxidation to sustain a portion of the physiological activity needs, but the major physiological functions of the protein are to sustain tissue growth, turnover and repair. During protein digestion, a small portion of the protein is notdigested; a portion of the digestion products of the protein is not absorbed. Unabsorbed and undigested proteins are subjected to bacterial action in the lower large intestine. The effect of bacteria on protein digests is called spoilage. The undigested protein is hydrolyzed under the catalysis of enzyme contained in the bacteria to generate amino acid, and the amino acid is decarboxylated under the action of decarboxylase contained in the bacteria to generate amine which is toxic to human bodies. Tyrosine generates phenol through a series of actions such as deamination, oxidation, decarboxylation and the like, and phenol is also toxic to human bodies. Under normal conditions, most putrefaction products of proteins are excreted with feces, and a small part is absorbed by intestinal mucosa and detoxified by liver. The diabetes patient takes protein as staple food, the concentration of amine absorbed into liver is often too high, the glucuronic acid antidote produced by liver microsome cells is limited, and the phenomenon of incomplete detoxification can occur, so that systemic amine poisoning and phenol poisoning are caused. The fast bioconversion food can rapidly discharge amine and phenol in large quantity, and avoid the poisoning of amine and phenol.
Free amino groups (-NH) on amine molecules2) Is a polar group.
Method for preparing food by quick biological conversion of (di) lipid, blood sugar, ketone body, amine and phenol
1. Raw material treatment
In autumn harvest, sunflower discs with the disc diameter of more than 22 cm are harvested. The sunflower disc is cut at the position where the receptacle extends 10 cm to the stem, a segment of sunflower stem about 45 cm is used for lightly beating the front surface of the sunflower disc, so that the sunflower seeds are loose, and then threshing is carried out, and attention is paid to: the front and back surfaces of the sunflower disc are not cracked, otherwise the sunflower disc is easy to be infected by mould and can not be eaten.
Removing seed from the sunflower disc, threading a small section of cotton rod at the position 5-6 cm away from the edge of the sunflower disc, tying a small coil, threading the coil with a paper clip, then fixing the paper clip on a wire mesh of a net room, hanging and naturally drying. Taking off the sunflower disc that dries thoroughly 3 months 20 days ago after in the next year, scrape off the positive support piece of sunflower disc and peripheral blade with the outer 90 degrees edges and corners of angle steel, divide into two halves with the sunflower disc from the middle, then grind all epidermis at the sunflower disc back with hand armful type mechanical grinding wheel, get sunflower disc sponge tissue, smash with the rubbing crusher, needn't sieve, the product is the unequal sunflower disc powder of granularity, packs with new ventilative braided bag, seals, and ventilation drying department deposits.
2. Solvent system: the drinking tap water without any pollution is selected.
3. Extraction method
Two stainless steel pots with the diameter of 34 cm and the height of 10 cm are taken and numbered 1 and 2.
Weighing 250 g of sunflower disc powder, putting the sunflower disc powder into a No. 1 basin, taking 5200 ml of 100 ℃ boiled water, adding half of the boiled water into the No. 1 basin, stirring the mixture uniformly clockwise or anticlockwise by using a rice spoon to ensure that the surfaces of all sunflower disc powder particles are fully contacted with the water, then adding the other half of the boiled water, stirring the mixture uniformly, covering the No. 2 basin, soaking the mixture for 10 minutes for sterilization, taking the covered No. 2 basin down after soaking for 10 minutes, washing the basin with clear water, putting the basin beside the No. 1 basin, taking two clean 40-mesh nylon yarn mesh bags, sleeving the two nylon yarn mesh bags together, putting the basin into the No. 2 basin, pouring the leaching liquor in the No. 1 basin into the double-layer nylon yarn mesh bag in the No. 2 basin, washing the basin No. 1 basin with clear water, putting the basin beside the No. 2 basin, holding the filtering bag mouth with a left hand, lifting the nylon yarn mesh bag with the left hand after half of the leaching liquor flows out of the mesh bag, putting the, pushing the right hand with the back of the rice spoon back and forth on the filter bag, the filter bag does not leave the leaching solution, when the viscosity of the extracting solution is as thick as rice soup, lifting the filter bag and placing the filter bag into the leaching solution of the basin No. 2, pushing the extracting solution in the basin No. 1, when the extracting solution is as thick as the extracting solution in the basin No. 1, continuously pushing the filter bag in the basin No. 2, extruding sticky mucus until the mucus cannot be extruded out, the mucus is merged into the extracting solution of the basin No. 1, adding 1100 ml of boiled water into the filter bag of the basin No. 2, uniformly shaking, continuously pushing, moving the mucus into the basin No. 1 with the rice spoon while pushing, pouring residues until the mucus cannot be extruded out, cleaning the basin No. 2 with clear water, placing the filter bag beside, putting a pair of dense white monofilament nylon elastic socks together, sleeving the filter bags together, placing the basin No. 2, pouring the extracting solution into the rice spoon, grasping the filtering bag mouth with the left hand, grasping and squeezing with the right hand, extruding mucus, removing residues, cleaning the filtering bag with clear water, cleaning No. 1 basin, filtering again, repeating for three times, removing residues, uniformly stirring the extract filtered for three times, filling into a clean empty alcohol bottle, about 4000 ml, covering the rubber plug tightly, storing in a refrigerator at 1 ℃, keeping the quality guarantee period for 2 days, and being edible for two days.
The experiment of the specific embodiment proves that: the quick biotransformation food is suitable for normal people, and people with hyperlipidemia, hypertension, atherosclerosis, fatty liver, obesity, diabetes, edema, stomach and abdominal distention, etc.; is not suitable for people with large amount of exercise and heavy physical labor to eat. The food can quench thirst and resist hunger after being eaten, drinking water and eating other foods are not needed within 3-4 hours, and the urine can be continuously discharged for 4-5 times after eating for 1 hour, which is a good phenomenon, because a large amount of blood fat, blood sugar, ketone body, glucose, fatty acid, amine, phenol and toxic substances such as food additives, medicines, pesticides and the like entering and staying in the body can be discharged, and the weight can be reduced by 1500-2000 g each day.
1. The eating method of the normal people, the people with hyperlipidemia, hypertension, atherosclerosis, fatty liver, obesity, edema and stomach and abdomen distension comprises the following steps:
two bottles of fast bioconversion food are taken out of the refrigerator, shaken evenly and poured into a round stainless steel lunch box, about 800-: 7.30-800; at noon: 11.30-12.00; in the afternoon: 4.00-4.30; and (2) evening: 8.00, every other day, a spoon of white sugar is added into breakfast to avoid hypoglycemia, and attention is paid to: when eating fast bioconversion foods, there is no sensation of thirst and hunger, and therefore no allowance for eating any other food (including meals, dishes, soups, milk, snacks, nuts, candies, etc.), and no effect. The food can be taken by ordinary meal for one day from day 6, fully supplementing sugar, protein, fat and vitamins, and taken again after day 7 until all indexes are considered to be satisfied, about 25 days, the normal activities of work, study and the like can not be influenced, and the food can be taken at will in the future.
2. The eating method for the diabetic patients comprises the following steps:
the salted vegetable is preheated by the same method, the salted vegetable is eaten together with rice or bread, the thirst can not be felt when the salted vegetable is eaten, one of the functions of the food is to quench the thirst, and the diabetic patients also need to supplement salt, and the experiment proves that: the diabetic can eat food in unlimited time and can eat food only by feeling thirst and hunger, and also has the phenomenon of large amount of urination, after eating, the phenomenon of hunger and thirst can slowly disappear, and the concentration of blood sugar, blood fat and ketone bodies can be reduced about seven days. When the concentrations of blood sugar, blood fat and ketone bodies reach a stable state, the food can be eaten in three days, and a feeding mode of supplementing protein, fat, vitamins and fructose in one day and discharging the protein, fat, vitamins and fructose in one day is adopted (the metabolic pathway of fructose in the body is that most of the fructose directly synthesizes fat, and with the food, a diabetic does not need to worry about the occurrence of hyperlipidemia, can supplement more fat and meet the energy requirement), but the food must be eaten in the afternoon and at dinner, and substances which cannot be fully utilized in the same day in the body are discharged to prevent accumulation.
The invention achieves the purposes of utilizing the combined transformation function of galacturonic acid to reduce fat, blood pressure, blood sugar and ketone body and fundamentally solving and preventing the problems of obesity, fatty liver, atherosclerosis, cerebral hemorrhage, cerebral thrombosis, amine poisoning, phenol poisoning, edema, stomach abdominal distension, diabetes and the like. The technology has the advantages of abundant and easily-obtained raw materials, low cost, simple process and no pollution, and the extracted residues are still biological substances, can be directly returned to the field as soil nutrients, and meet the requirements of food and environmental protection.
Claims (1)
- A method for preparing foods of lipid, blood sugar, ketone body, amine and phenol by quick biotransformation belongs to the biochemical technology1. Method for preparing food by quick biotransformation of lipid, blood sugar, ketone body, amine and phenol(1) Raw material treatmentIn autumn harvest, sunflower discs with the disc diameter of more than 22 cm are harvested. The sunflower disc is cut at the position where the receptacle extends 10 cm to the stem, a segment of sunflower stem about 45 cm is used for lightly beating the front surface of the sunflower disc, so that the sunflower seeds are loose, and then threshing is carried out, and attention is paid to: the front and back surfaces of the sunflower disc are not cracked, otherwise the sunflower disc is easy to be infected by mould and can not be eaten.Removing seed from the sunflower disc, threading a small section of cotton rod at the position 5-6 cm away from the edge of the sunflower disc, tying a small coil, threading the coil with a paper clip, then fixing the paper clip on a wire mesh of a net room, hanging and naturally drying. Taking off the sunflower disc that dries thoroughly 3 months 20 days ago after in the next year, scrape off the positive support piece of sunflower disc and peripheral blade with the outer 90 degrees edges and corners of angle steel, divide into two halves with the sunflower disc from the middle, then grind all epidermis at the sunflower disc back with hand armful type mechanical grinding wheel, get sunflower disc sponge tissue, smash with the rubbing crusher, needn't sieve, the product is the unequal sunflower disc powder of granularity, packs with new ventilative braided bag, seals, and ventilation drying department deposits.(2) Solvent system: the drinking tap water without any pollution is selected.(3) Extraction methodTwo stainless steel pots with the diameter of 34 cm and the height of 10 cm are taken and numbered 1 and 2.Weighing 250 g of sunflower disc powder, putting the sunflower disc powder into a No. 1 basin, taking 5200 ml of 100 ℃ boiled water, adding half of the boiled water into the No. 1 basin, stirring the mixture uniformly clockwise or anticlockwise by using a rice spoon to ensure that the surfaces of all sunflower disc powder particles are fully contacted with the water, then adding the other half of the boiled water, stirring the mixture uniformly, covering the No. 2 basin, soaking the mixture for 10 minutes for sterilization, taking the covered No. 2 basin down after soaking for 10 minutes, washing the basin with clear water, putting the basin beside the No. 1 basin, taking two clean 40-mesh nylon yarn mesh bags, sleeving the two nylon yarn mesh bags together, putting the basin into the No. 2 basin, pouring the leaching liquor in the No. 1 basin into the double-layer nylon yarn mesh bag in the No. 2 basin, washing the basin No. 1 basin with clear water, putting the basin beside the No. 2 basin, holding the filtering bag mouth with a left hand, lifting the nylon yarn mesh bag with the left hand after half of the leaching liquor flows out of the mesh bag, putting the, pushing the right hand with the back of the rice spoon back and forth on the filter bag, the filter bag does not leave the leaching solution, when the viscosity of the extracting solution is as thick as rice soup, lifting the filter bag and placing the filter bag into the leaching solution of the basin No. 2, pushing the extracting solution in the basin No. 1, when the extracting solution is as thick as the extracting solution in the basin No. 1, continuously pushing the filter bag in the basin No. 2, extruding sticky mucus until the mucus cannot be extruded out, the mucus is merged into the extracting solution of the basin No. 1, adding 1100 ml of boiled water into the filter bag of the basin No. 2, uniformly shaking, continuously pushing, moving the mucus into the basin No. 1 with the rice spoon while pushing, pouring residues until the mucus cannot be extruded out, cleaning the basin No. 2 with clear water, placing the filter bag beside, putting a pair of dense white monofilament nylon elastic socks together, sleeving the filter bags together, placing the basin No. 2, pouring the extracting solution into the rice spoon, grasping the filtering bag mouth with the left hand, grasping and squeezing with the right hand, extruding mucus, removing residues, cleaning the filtering bag with clear water, cleaning No. 1 basin, filtering again, repeating for three times, removing residues, uniformly stirring the extract filtered for three times, filling into a clean empty alcohol bottle, about 4000 ml, covering the rubber plug tightly, storing in a refrigerator at 1 ℃, keeping the quality guarantee period for 2 days, and being edible for two days.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100398458A CN1672581A (en) | 2004-03-23 | 2004-03-23 | Making process of food for fast biologically conversion of lipid, blood sugar, ketobodies, amines and phenol |
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| CNA2004100398458A CN1672581A (en) | 2004-03-23 | 2004-03-23 | Making process of food for fast biologically conversion of lipid, blood sugar, ketobodies, amines and phenol |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110169580A (en) * | 2019-06-26 | 2019-08-27 | 重庆康泉健康管理有限公司 | Adjust metabolism, blood glucose, blood pressure, the comprehensive nutrition powder of blood lipid and preparation method thereof |
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2004
- 2004-03-23 CN CNA2004100398458A patent/CN1672581A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110169580A (en) * | 2019-06-26 | 2019-08-27 | 重庆康泉健康管理有限公司 | Adjust metabolism, blood glucose, blood pressure, the comprehensive nutrition powder of blood lipid and preparation method thereof |
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