CN1667123A - Gene cluster responsible for synthesis of FR-008 polyketone antibiotics - Google Patents
Gene cluster responsible for synthesis of FR-008 polyketone antibiotics Download PDFInfo
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Abstract
This invention is a gene cluster used to take charge of FR-008 polyketone synthesis in streptomycete FR-008, it belongs to gene technique field. It includes fscA, fscB, fscC, fscD, fscE, fscF, fscTI, fscBTII, fscRI, fscRII, fscRIII, fscRIV, fsP, fscFE, fscTE, fscMI, fscMII, fscMIII, fscO, pabAB, pabC, 21 gene and their DNA sequence, it is sequence 1. Amino acid sequence of these gene and its DNA sequence coding FR-008 organism synthetase, it is sequence 22. The gene and protein coded by the gene in this invention can be used to search and develop compound or albumen used for medicine, industrial and agriculture.
Description
Technical field
What the present invention relates to is a kind of polyketone antibiotic and biosynthesis gene thereof, and polyenoid polyketide synthase gene cluster among particularly a kind of streptomycete FR-008 belongs to biotechnology gene field.
Technical background
Microbiotic is produced by microorganism, plant and animal etc., can just can kill or suppress the secondary metabolite of other biological growth under lower concentration very.The penicillin that produces as Institute of Micro-biology, as the taxol (taxol) of cancer therapy drug etc.Microbiotic plays a role by one or more physiological metabolism processes of disturbing target cell.Polyketone is a class natural product, and a lot of polyketides have been applied to medical, for animals and agricultural, comprise erythromycin (antibiotic), nystatin (antimycotic), Avrmectin (antiparasitic), rapamycin (immunosuppressor) and daunorubicin (antitumor).The gram-positive microorganism streptomycete is the main generation bacterium of polyketone antibiotic.Synthetic and the lipid acid of polyketone synthetic similar, it all is condensation course via the simple carboxylic unit of polyketide synthase mediation, and with the synthetic relevant synthetic gene of polyketone antibiotic, regulatory gene and resistant gene close linkage often in bacterial genomes, cluster arrangement.Being responsible for DEBS polyketide synthase that the erythromycin macrolide forms and being first example is found and has modular structure.Along with the separation and the evaluation of more and more macrolide polyketone, its modularized core notion does not change all the time.The modular structure of I type polyketide synthase comprises multiple ketone group synthetase structure domain (KS); acyltransferase structural domain (AT); acyl carrier protein structural domain (ACP) (also may comprise keto reductase structural domain (KR); dehydrogenase structure domain (DH); enoyl reductase structural domain (ER)); each module is responsible for the primary first-order equation of polyketone chain extension, and they are determining the reduction step of the extender unit of adding.In addition, also need the cyclisation and the release of the effect catalysis polyketone chain of thioesterase (TE) structural domain.At last, also to pass through glycosylation, hydroxylation, methylate and modification step such as acylations.For example immunosuppressor FK506 activates with the required signal transduction path of growing by suppressor T cell and hinders immunne response.FK506 is used to prevent transplant and rejects reaction.And be used to the treatment of some autoimmune disease.Structurally, FK506 also is a macrolide, can be produced by some streptomycetes.
The modular structure of polyketone biosynthesizing PKS is formed and is had certain plasticity-, makes genetically engineered operations such as the insertion of the specificity of number that people can be by changing module, extension of module or structural domain or inactivation obtain new polymeric polyketone derivatives.
The multifarious valuable source of natural macrolide antibiotic is institute's bonded glycosyl on the aglucon specific site of center.These glycosyl components be found almost all with microbiotic and its cell between the effective object molecular recognition relevant.Many naturally occurring bioactive metabolites carry uncommon glycosyl, as the key element of bioactive molecules identification.Recently, for the microbiotic that is used to produce novel glycosyl heterozygosis more and more of understanding in depth of FscM and other glycosyl synthetic gene.FscM makes FscM become the biosynthetic noticeable instrument of combination to certain adaptability of substrate.
Amino trehalose group is present in a lot of macrolide antibiotic molecules, and most of polyene antibiotic molecule carries this special amino trehalose group.The amino trehalose route of synthesis of prediction comprises coming the GDP-seminose in the autonomous metabolism to be converted into GDP-4-ketone group-6-deoxidation-D-seminose under the effect of GDP-seminose dehydratase, isomery turns to GDP-3-ketone group-6-deoxidation-D-seminose then, and the transamination by GDP-ketose transaminase at last forms the amino trehalose of GDP-.Wherein isomerization may not need the participation of enzyme.
Another important feature of natural antibiotics is can obtain very large-scale constitutional features through the modification of oxidasic back on the synthetic good center aglucon specific site.The back modification of these oxydase mediations comprises carboxylated, hydroxylation, epoxidation etc.In most cases these back modification steps cause producing the pharmacophore characteristic.Thereby these back modification oxidase genes have very big chemistry and pharmacology importance.In the combination biosynthesizing, the oxidase gene that these backs are modified is being played the part of important role.Consider the vital role of modified protein aspect biological activity and structure diversity behind the polyketide, the back is modified oxidase gene and can be applied and enlarge the work box that can use the back modifying enzyme more widely.Recently, modify the microbiotic that is used to produce novel heterozygosis more and more of understanding in depth of oxidase gene for the back.Modification oxidase gene in back also makes it become the biosynthetic noticeable instrument of combination to certain adaptability of substrate.
Polyketone FscP catalyged precursor polyketone locus specificity oxidation and obtain final macrolide antibiotic comprises erythromycin, tylosin, romicil, Avrmectin etc.The effect substrate of these polyketone FscPs and all be very different at the action site of same substrate.The subtle change of substrate structure makes a big impact for these oxydase action activities.
On the other hand, all the time, improving output is the priority issues that the microbiotic industrial production is devoted to solve.Yet traditional passing through improves fermentation condition, or more and more is restricted by the antibiotics generated bacterium of chemomorphosis screening output raising, and is easy to reach capacity.Along with the particularly engineered develop rapidly of development of biology, provide by transforming dependency basis in the antibiotics generated bacterium thereby increasing substantially the approach of microbiotic output.This wherein increases the positive regulator gene copy number or interrupts negative regulator gene is one of most important approach.
Polyene macrolide is a class comprises 3-8 continuously two keys in macrolide a polyketide.Polyene antibiotic forms passage by the sterol interaction with eukaryotic cell membrane and causes that micromolecular losing causes necrocytosis.
The polyene macrolide antibiotics amphotericin B is a kind of at the antifungal antibiotic that pharmaceutically has important use of tuberculosis streptomycete generation.Amphotericin B has very big affinity to the sterol ergosterol of quantity maximum in the fungal cell membrane, thereby the fungal cell is had optionally toxicity.Yet it also can be had an effect with the cholesterol in the mammalian cell membrane and have toxicity, especially renal toxicity.However, amphotericin B remains the human serious most important microbiotic of systemic fungal infection.Amphotericin B also can make culturing cell avoid the infection of virus of AIDS (HIV).Polyene macrolide antibiotics nystatin also is the important medical microbiotic of human fungi infestation.Candicidin D is a kind of fragrant seven alkene macrolide antibiotics that produced by streptomyces griseus IMRU3570.It has very strong inhibition activity to candidiasis.
Summary of the invention
The present invention is according to the deficiency that exists in the background technology and the technical issues that need to address, FR-008 biological synthesis gene cluster among a kind of streptomycete FR-008 is provided, a kind of polyenoid polyketone antibiotic FR-008 of its generation has anti-mycotic activity and to the high toxicity of larvae, and can prevent prostatauxe and can prevent that trichomonas vaginitis from infecting and candidal vaginitis.
The invention provides polyenoid polyketone FR-008 biological synthesis gene cluster among a kind of streptomycete FR-008, promptly comprise fscA, fscB, fscC, fscD, fscE, fscF, fscTI, fscTII, fscRI, fscRII, fscRIII, fscRIV, fscP, fscFE, fscTE, fscMI, fscMII, fscMIII, fscO, pabAB, pabC this a series of totally 21 genes and dna sequence dna thereof, promptly sequence 1, and the aminoacid sequence of these genes and the coded FR-008 biosynthetic enzyme of dna sequence dna thereof, i.e. sequence 2-22 are provided; Comprise comprising base 20 in the sequence 1,927-26,158 gene fscA comprises base 60 in the sequence 1,860-28,983 gene fscC comprises base 77 in the sequence 1,587-60,962 gene fscB comprises base 84 in the sequence 1,132-77,983 gene fscF comprises base 107 in the sequence 1,485-84,170 gene fscE comprises base 136 in the sequence 1,148-107, the nucleotide sequence of 496 gene fscD, the polyketide synthase of having encoded; Comprise comprising base 26 in the sequence 1 333-27,340 gene fscTI, comprise base 27 in the sequence 1,561-28,280 gene fscTII, comprise base 3 in the sequence 1,818-3,150 gene fscRI, comprise base 7 in the sequence 1,205-4,377 gene fscRII, comprise base 10 in the sequence 1,320-7,210 gene fscRIII, comprise base 13 in the sequence 1,315-10,298 gene fscRIV comprises base 16 in the sequence 1,106-17,287 gene fscP comprises base 17 in the sequence 1,334-17,528 gene fscFE, comprise base 17 in the sequence 1,556-18,413 gene fscTE, comprise base 13 in the sequence 1,522-14,898 gene fscMI comprises base 14 in the sequence 1,953-16,011 gene fscMII comprises base 137 in the sequence 1,766-136,558 gene fscMIII, comprise base 1 in the sequence 1, the gene fscO of 950-574 comprises base 18 in the sequence 1,610-20,781 gene pabAB comprises base 3 in the sequence 1,037-2, the nucleotide sequence of 264 gene pabC, the abc transport albumen of having encoded is regulated albumen, FscP, Triphosphopyridine nucleotide photoreductase, II type thioester enzyme, FscM, FscM, rely on the mono-oxygenase of FAD, the para-amino benzoic acid synthetic enzyme.Total biosynthetic 6 the polyketide synthase genes of FR-008,4 regulatory gene, 2 transporter genes be responsible for, 2 para-amino benzoic acid synthetic genes, 2 FscMs, 1 FscM gene and 4 modifying factors obtain to confirm, and the aminoacid sequence of these coded by said gene enzymes are provided.
The present invention realizes according to following technical scheme, the invention provides a kind of polyketide synthase of having encoded among the streptomycete FR-008, abc transport albumen of coming from, regulate albumen, FscP, Triphosphopyridine nucleotide photoreductase, II type thioester enzyme, FscM, FscM, rely on the mono-oxygenase of FAD, the microbiotic FR-008 gene cluster of para-amino benzoic acid synthetic enzyme, and the aminoacid sequence of the coded FR-008 biosynthetic enzymes of these nucleotide sequences is provided, that is to say that these enzymes are defined by the aminoacid sequence that sequence 2-22 provides, these nucleotide sequences be selected from respectively comprise in the sequence 1 fscA (20,927-26,158), and fscC (60,860-28,983), and fscB (77,587-60,962), and fscF (84,132-77,983), and fscE (107,485-84,170), and fscD (136,148-107,496), and fscTI (26,333-27,340), and fscTII (27,561-28,280), and fscRI (3,818-3,150), and fscRII (7,205-4,377), and fscRIII (10,320-7,210), and fscRIV (13,315-10,298), and fscP (16,106-17,287), and fscFE (17,334-17,528), and fscTE (17,556-18,413), and fscMI (13,522-14,898), and fscMII (14,953-16,011), and fscMIII (137,766-136,558), and fscO (1,950-574), pabAB (18,610-20,781), pabC (3,037-2,264) series of genes sequence.
Comprise and comprise base 20 in the sequence 1; 927-26; 158 gene fscA comprises base 60 in the sequence 1,860-28; 983 gene fscC; comprise base 77 in the sequence 1,587-60,962 gene fscB; comprise base 84 in the sequence 1; 132-77,983 gene fscF comprises base 107 in the sequence 1; 485-84; 170 gene fscE comprises base 136 in the sequence 1,148-107; the polyketide synthase genes encoding of 496 gene fscD include the polyketide synthase module the ketone group synthetase structure domain be the KS structural domain; the acyltransferase structural domain is the AT structural domain, and the acyl carrier protein structural domain is the ACP structural domain, and also may comprise the keto reductase structural domain is the KR structural domain; dehydrogenase structure domain is the DH structural domain, and the enoyl reductase structural domain is the polyketide synthase of ER structural domain.
By the FR-008 biosynthetic enzyme of sequence 2-22 definition corresponding to biosynthetic each synthesis step of FR-008 and back modification and adjusting, transhipment, correcting process.
The present invention also provides coding to comprise ATP dependency carboxylic acid: CoA ligase (CoL), ACPL, KS1, AT1, the nucleotide sequence of the dna molecular of the FR-008 polyketide synthase structural domain of ACP1, these structural domains are respectively by amino acid 51-465 in the sequence 2,581-647,661-1,094,1,202-1,509,1,596-1,662 describe, the nucleotide sequence of called after fscA gene is selected from and comprises 20,927-26, a series of bases of 158 in the sequence 1.
The present invention also provides coding to comprise KS10, AT10, DH10, KR10, ACP10, KS9, AT9, DH9, KR9, ACP9, KS8, AT8, DH8, KR8, ACP8, KS7, AT7, DH7, KR7, ACP7, KS6, AT6, DH6, KR6, ACP6, KS5, AT5, DH5, KR5, the nucleotide sequence of the dna molecular of the FR-008 polyketide synthase structural domain of ACP5, these structural domains are respectively by amino acid 8 in the sequence 3,808-9,221; 9,330-9,627; 9,680-9,867; 10,183-10,366; 10,469-10,536; 6,966-7,383; 7,490-7,792; 7,845-8,029; 8,331-8,514; 8,618-8,685; 5,253-5,675; 5,775-6,074; 6,127-6,310; 6,590-6,773; 6,874-6,941; 3,529-3,954; 4,059-4,356; 4,407-4,595; 4,884-5,063; 5,163-5,230; 1,787-2,212; 2,318-2,617; 2,670-2,859; 3,155-3,338; 3,438-3,505; 34-460; 576-875; 928-1,112; 1,417-1,596; 1,696-1,763 describe, and the nucleotide sequence of called after fscC gene is selected from and comprises 60,860-28, a series of bases of 983 in the sequence 1.
The present invention also provides coding to comprise KS4, AT4, DH4, KR4, ACP4, KS3, AT3, DH3, ER3, KR3, ACP3, KS2, AT2, KR2, the nucleotide sequence of the dna molecular of the FR-008 polyketide synthase structural domain of ACP2, these structural domains are respectively by amino acid 3 in the sequence 4,703-4,103; 4,247-4,550; 4,600-4,722; 5,103-5,286; 5,389-5,456; 1,597-2,023; 2,139-2,442; 2,494-2,684; 2,970-3,322; 3,325-3,508; 3,610-3,677; 33-460; 571-874; 1,224-1,406; 1,508-1,574 describe, and the nucleotide sequence of called after fscB gene is selected from and comprises 77,587-60, a series of bases of 962 in the sequence 1.
The present invention also provides coding to comprise KS21, and AT21, DH21, KR21, ACP21, the nucleotide sequence of the dna molecular of the FR-008 polyketide synthase structural domain of TE21, these structural domains are respectively by amino acid 33-456 in the sequence 5; 545-851; 903-1,083; 1,378-1,561; 1,668-1,735; 1,814-2,018 describes, and the nucleotide sequence of called after fscF gene is selected from and comprises 84,132-77, a series of bases of 983 in the sequence 1.
The present invention also provides coding to comprise KS20, AT20, DH20, ER20, KR20, ACP20, KS19, AT19, KR19, ACP19, KS18, AT18, DH18, ER18, KR18, ACP18, KS17, AT17, DH17, ER17, KR17, the nucleotide sequence of the dna molecular of the FR-008 polyketide synthase structural domain of ACP17, these structural domains are respectively by amino acid 5 in the sequence 6,642-6,069; 6,158-6,463; 6,515-6,693; 7,017-7,322; 7,330-7,512; 7,615-7,682; 4,117-4,544; 4,633-4,936; 5,263-5,445; 5,552-5,619; 2,071-2,498; 2,590-2,896; 2,948-3,127; 3,428-3,733; 3,741-3,924; 4,025-4,092; 34-460; 548-850; 902-1,081; 1,384-1,689; 1,697-1,880; 1,982-2,049 describes, and the nucleotide sequence of called after fscE gene is selected from and comprises 107,485-84, a series of bases of 170 in the sequence 1.
The present invention also provides coding to comprise KS16, AT16, KR16, ACP16, KS15, AT15, KR15, ACP15, KS14, AT14, KR14, ACP14, KS13, AT13, KR13, ACP13, KS12, AT12, KR12, ACP12, KS11, AT11, DH11, KR11, the nucleotide sequence of the dna molecular of the FR-008 polyketide synthase structural domain of ACP11, these structural domains are respectively by amino acid 7 in the sequence 7,935-8,352; 8,464-8,767; 9,099-9,280; 9,387-9,452; 6,425-6,845; 6,935-7,241; 7,559-7,725; 7,838-7,898; 4,872-5,297; 5,408-5,720; 6,049-6,225; 6,331-6,398; 3,342-3,765; 3,872-4,170; 4,499-4,676; 4,782-4,849; 1,788-2,209; 2,313-2,621; 2,972-3,150; 3,254-3,314; 38-452; 563-864; 921-1,105; 1,410-1,592; 1,694-1,760 describe, and the nucleotide sequence of called after fscD gene is selected from and comprises 136,148-107, a series of bases of 496 in the sequence 1.
The present invention also provides the nucleotide sequence of 2 the proteic genes of abc transport of encoding, these two abc transport albumen are made up of the aminoacid sequence of sequence 8 and sequence 9 respectively, called after fscTI, the nucleotide sequence of fscTII gene is selected from the sequence 1 and comprises 26,333-27,340,27,561-28, a series of bases of 280.
The present invention also provides 4 nucleotide sequences of regulating proteic gene of encoding, and regulates albumen respectively by sequence 10,11,12 for these 4,13 aminoacid sequence is formed, called after fscRI, fscRII, fscRIII, the nucleotide sequence of fscRIV gene is selected from the sequence 1 and comprises 3,818-3,150,7,205-4,377,10,320-7,210,13,315-10, a series of bases of 298.
The present invention also provides the nucleotide sequence of the gene of the FscP of encoding, this FscP is made up of the aminoacid sequence of sequence 14, the nucleotide sequence of called after fscP gene is selected from the sequence 1 and comprises 16,106-17, a series of bases of 287.
The present invention also provides the nucleotide sequence of the gene of the Triphosphopyridine nucleotide photoreductase of encoding, this Triphosphopyridine nucleotide photoreductase is made up of the aminoacid sequence of sequence 15, the nucleotide sequence of called after fscFE gene is selected from the sequence 1 and comprises 17,334-17, a series of bases of 528.
The present invention also provides the nucleotide sequence of the gene of the II type thioester enzyme of encoding, this II type thioester enzyme is made up of the aminoacid sequence of sequence 16, the nucleotide sequence of called after fscTE gene is selected from the sequence 1 and comprises 17,556-18, a series of bases of 413.
The present invention also provides the nucleotide sequence of the gene of encode 2 FscMs and 1 FscM, FscM is made up of the aminoacid sequence of sequence 17,2 FscMs (GDP-ketose transaminase and GDP-seminose dehydratase) are made up of the aminoacid sequence of sequence 18 and sequence 19 respectively, called after fscMI, fscMII, the nucleotide sequence of fscMIII gene is selected from the sequence 1 and comprises 13,522-14,898,14,953-16,011,137,766-136, a series of bases of 558.
The present invention also provides the nucleotide sequence of the gene of the mono-oxygenase that relies on FAD of encoding, this mono-oxygenase albumen that relies on FAD is made up of the aminoacid sequence of sequence 20, the nucleotide sequence of called after fscO gene is selected from the sequence 1 and comprises 1, a series of bases of 950-574.
The present invention also provides the nucleotide sequence of the gene of 2 the para-amino benzoic acid synthetic enzyme of encoding, these two para-amino benzoic acid synthetic enzyme are made up of the aminoacid sequence of sequence 21 and 22 respectively, the nucleotide sequence of called after pabAB and pabC gene is selected from the sequence 1 and comprises 18,610-20,781,3,037-2, a series of bases of 264.
The present invention also provides from carry partial sequence 1 recombinant vectors at least, or from the microorganism library, or separates the approach of FR-008 biosynthesis gene from microbial staining body DNA.
The present invention also provides a fragment to come from least in the sequence 1 polyketide synthase sequence to make up recombinant vectors to obtain the approach of novel polyketone with the polyketone sequence that comes from other polyketide synthase gene cluster.
The present invention also provides the approach that improves FR-008 or its microbiotic output of deriving in the genetically engineered microorganism body.
The present invention also provides the approach of simplifying the active principle of FR-008.
The present invention also provides the approach that is comprised the recombinant DNA carrier of dna sequence dna in the partial sequence 1 at least.
The present invention also provides and has produced the approach that the recombinant DNA carrier that is comprised dna sequence dna in the partial sequence 1 at least transforms the host cell that enters, and the polyketone that this host cell produced is the analog of FR-008 or FR-008.
The present invention also provides the approach that the recombinant DNA carrier that is comprised dna sequence dna in the partial sequence 1 at least transforms the host cell that enters that produces, and the analog output of FR-008 that this host cell produced or FR-008 is improved or the microbiotic or certain meta-bolites output that are produced are improved.
The present invention also provides to be created in has the FR-008 biosynthesis gene to be interrupted in the genome, the approach of the microbe that lacks or double, and the gene of one of them includes the nucleotide sequence in the sequence 1 at least.
The present invention also provides the approach that the microbe that the FR-008 biosynthesis gene transformed is arranged in the genome that is created in.
The present invention also provides to be created in the FR-008 biosynthetic enzyme one of the polyketide synthase structural domain or the approach of one of them microbe that is lacked or double or transform at least in the genome.
The complementary sequence of sequence 1 can obtain at any time according to DNA base complementrity principle.The nucleotide sequence of sequence 1 or partial nucleotide sequence can be cut corresponding DNA or use other suitable technique to obtain at any time by polymerase chain reaction (PCR) or with suitable enzyme.Comprise invention the dna fragmentation or the gene of the sequence that provides or a plurality of sequences can obtain at any time.By nucleotide sequence provided by the present invention or partial nucleotide sequence, the DNA that can utilize the method for polymerase chain reaction (PCR) or comprise sequence of the present invention obtains the gene similar to the FR-008 biosynthesis gene as the method that probe carries out Southern hybridization from other organism.
Nucleotide fragments provided by the invention can be used to separate the bioactive structural domain of tool from streptomycete FR-008 or other bacterial classification.For example, polymerase chain reaction (PCR) can be passed through in the biological activity site of polyketide synthase structural domain and modifying factor, and restriction enzyme site or other suitable technique obtain.
Nucleotide sequence provided by the invention or a plurality of sequence can obtain recombination sequence and corresponding D NA molecule with the fusion of carrier sequence.
Comprise nucleotide sequence provided by the present invention or the clone gene or the dna fragmentation of partial sequence can obtain new FR-008 derivative by interrupting biosynthetic one or several synthesis step of FR-008 at least.
Comprise nucleotide sequence provided by the present invention or the clone gene or the dna fragmentation of partial sequence can obtain new FR-008 derivative by interrupting biosynthetic one or several modification step of FR-008 at least.
Comprise the output that dna fragmentation or gene can be used for improving the FR-008 or derivatives thereof.For example, change the positive regulator gene of multiple copied more or interrupt negative regulator gene over to.
Comprise nucleotide sequence provided by the present invention or at least the cloned DNA of partial sequence can be used to from streptomycete FR-008 genomic library more library, location plasmid.These library plasmids include the partial sequence among the present invention at least, also include the DNA that former adjacent domain is not cloned in the streptomycete FR-008 genome.
Nucleotide sequence provided by the present invention can be modified or be suddenlyd change.These approach comprise insertion or displacement, the polymerase chain reaction, and mistake mediation polymerase chain reaction, the locus specificity sudden change, not homotactic reconnecting, or by ultraviolet ray or chemical reagent.
The different piece that nucleotide sequence provided by the present invention can be by sequence or the homologous sequence in other source directly evolve (DNA shuffling).
Come from one or more polyketide synthase structural domains of identical or different polyketide synthase systems by disappearance or inactivation, module or gene, or increase one or more polyketide synthase structural domains, module or gene and produce new polyketide.Comprise sequence of the present invention or at least the clone gene of partial sequence can in foreign host, express with the polyketide synthase that obtains modifying or higher biological activity or higher output by appropriate expression system. these foreign host comprise streptomycete, intestinal bacteria, genus bacillus, yeast, plant and animal etc.
Comprise nucleotide sequence of the present invention or the fragment of partial sequence or structural domain or module or polyketide synthase gene can be used for making up polyketide synthase storehouse or polyketide synthase derive storehouse or combinatorial libraries at least.
Comprise the nucleotide sequence of the present invention or the modifying factor of partial sequence at least, regulatory gene, the synthetic and transferase gene of transporter gene or glycosyl can be used for making up derive storehouse or combinatorial libraries.
FR-008 biosynthesizing modifying factor, regulatory gene, transporter gene or glycosyl nucleotide sequence synthetic and transferase gene provides by disappearance or has transformed these modifying factors, regulatory gene, the synthetic approach that obtains the raising of FR-008 structural derivative or FR-008 and derivative output thereof with transferase gene of transporter gene or glycosyl.
Contain nucleotide sequence of the present invention or a fragment of partial sequence or the carrier that several fragment can be cloned into improved bacterial artificial chromosome (BAC) or yeast artificial chromosome (YAC) or Ke Si carrier (Cosmid) or expression vector or other type at least, with should suitable needs.
Contain nucleotide sequence of the present invention or at least partial sequence gene or gene cluster can be expressed in heterologous host and understand their roles in host's metabolic chain by the DNA chip technology.
Comprise aminoacid sequence of the present invention or at least the polypeptide of partial sequence (sequence 2-22) may after remove or substitute certain or some amino acid, still have biological activity even new biologic activity is arranged, perhaps improved output or optimization albumen dynamic characteristic or other character of being devoted to obtain.
By the suitable technique disappearance, the aminoacid sequence that connects among the present invention can obtain new albumen or enzyme, and then produces the new polyketone or the product of associated.
The present invention has substantive distinguishing features and obvious improvement, the output that gene order provided by the present invention can be used for producing the gene engineered antibiotic or the hybrid antibiotic of expection or is used to improve microbiotic or gene engineered antibiotic.Aminoacid sequence provided by the present invention can be used for separating the protein of needs and can being used for Antibody Preparation.Aminoacid sequence provided by the present invention provides the possibility of prediction polyketide synthase three-dimensional structure, and then provides foundation for transforming or improving protein-active.Gene provided by the present invention and coded bak protein thereof, corresponding antibody or multinuclear glycosides can be used for searching and development can be used for medicine, industry, the compound or the albumen of agricultural.
Description of drawings
Below by accompanying drawing the present invention is further described:
Fig. 1 is used for checking order covering the library coemid and the subclone of whole FR-008 gene cluster
Fig. 2 is for being responsible for the structure of the biosynthetic whole FR-008 gene cluster of FR-008.Comprise structure gene, modifying factor, regulatory gene is corrected gene and transporter gene etc., is responsible for biosynthesizing and adjusting and the outward transport of FR-008.
Fig. 3 is a FR-008 chemical structure synoptic diagram.Be numbered the amino trehalose group that is of C1 '-C6 '.The carboxylated C-18 position that occurs in, hydroxylation occurs in the C-9 position.R1 representation hydroxy or ketone group, R2 representation hydroxy or H atom.
Fig. 4 proves for the hybridization that the gene substitution of regulatory gene mutant strain takes place.A is the synoptic diagram that gene substitution takes place; B is that the hybridization of transgenation strain proves.HJ-1, HJ-2, the These positive bands (4.3kb) of HJ-3 and 1.5kb hybridization is than the big 2.8kb of These positive bands (1.5kb) of wild-type, because HJ-1, HJ-2, apramycin/erythromycin resistance gene has been replaced regulatory gene in the karyomit(e) of HJ-3.
Fig. 5 is a regulatory gene mutant strain biological activity determination.About the below 3 mutant strains all no longer produce inhibition zone.Directly over be the wild-type contrast.
Near the amino acid whose comparison of keto reductase structural domain (KR) control steric configuration specific amino acids that Fig. 6 adheres to for two keys and glycosyl in the responsible FR-008 molecule.KR8, this specific amino acids of KR9 and KR12 becomes glycine (G) respectively by aspartic acid, N (N) and L-Ala (A).
Embodiment
As depicted in figs. 1 and 2, sequence description in the sequence list of the present invention:
Sequence 9 is the aminoacid sequence of the abc transport albumen (FscTII) of fscTII gene (Nucleotide 27 in the sequence 1,561-28,280) coding.
Below further the present invention is described in detail:
Because FR-008 has anti-mycotic activity, larvae there is high toxicity and can prevents prostatauxe and can prevent the trichomonas vaginitis infection and candidal vaginitis and in other industry, agricultural, the application potential that is pharmaceutically had, the present invention has separated the biosynthetic gene cluster of responsible FR-008, cover five coemids of whole gene cluster, pHZ145, pHZ137, pHZ220, pHZ194 and pJTU1 connect same subclone plasmid pJTU6 and are used to order-checking, and pJTU6 has carried 5.2kb and the 7.5kb BamHI fragment of pHZ141, but 7.5kb is opposite in the karyomit(e) to the segmental direction of 5.2kb and pHZ141 in other words, pHZ145, pHZ137, the carrier of pHZ194 and pJTU10 are pHZ132, the carrier of pHZ220 is pIJ653, and the carrier of pJTU6 is pBluescriptII SK (+).
Order-checking obtains 138, the continuous nucleotide sequence of 203bp.In whole 21 open reading frames, 6 I type polyketide synthase genes (fscA-fscF) are arranged.The Conserved Domain Database search at FramePlot 2.3.2 software and American National bioinformation center and the worldwide Blast engine that provides thereof are provided in sequential analysis.Thereby the fscA-fscF amino acid sequence coded compares the functional character (seeing Fig. 1 for details) that draws these polypeptide by the aminoacid sequence with some I type polyketide synthases of fully having been understood.
The polyketide synthase gene order:
In the sequence 1 20,927-26,158 and 28,983-136,148 bases are to be responsible for the sequence of FR-008 lactonic ring synthetic polyketide synthases gene, have 6 polyketide synthase genes in the FR-008 gene cluster, and the nucleotide sequence of two abc transport of one section coding is arranged between fscA and fscC.The nucleotide sequence of each polyketide synthase gene and amino acid sequence corresponding in the FR-008 gene cluster, as shown in table 1:
Table 1:
| Gene gene | Base position in the | Amino acid sequence corresponding |
| ????fscA ????fscC ????fscB ????fscF ????fscE ????fscD | ????20,927-26,158 ????60,860-28,983 ????77,587-60,962 ????84,132-77,983 ????107,485-84,170 ????136,148-107,496 | ????SEQ?ID?NO：2 ????SEQ?ID?NO：3 ????SEQ?ID?NO：4 ????SEQ?ID?NO：5 ????SEQ?ID?NO：6 ????SEQ?ID?NO：7 |
FscA coding FR-008 lactonic ring synthetic starting module and extension of module 1 (base 20 in the sequence 1,927-26,158).
Structural domain in starting module and the extension of module 1 is as shown in table 2 in the position of FscA:
Table 2:FscA
| Structural domain | Amino acid position in FscA (sequence 2) |
| ????CoL ????ACPL ????KS1 ????AT1 ????ACP1 | ????51-465 ????581-647 ????661-1,094 ????1,202-1,509 ????1,596-1,662 |
FscC six extension of module of FR-008 lactonic ring synthetic (extension of module 10,9, base 60 in 8,7,6,5 sequences 1,860-28,983) of encoding
Structural domain in these extension of module is as shown in table 3 in the position of FscC:
Table 3:FscC
| Structural domain | Amino acid position in FscC (sequence 3) |
| ????KS10 ????AT10 ????DH10 ????KR10 ????ACP10 ????KS9 ????AT9 ????DH9 ????KR9 ????ACP9 ????KS8 ????AT8 ????DH8 ????KR8 ????ACP8 | ????8,808-9,221 ????9,330-9,627 ????9,680-9,867 ????10,183-10,366 ????10,469-10,536 ????6,966-7,383 ????7,490-7,792 ????7,845-8,029 ????8,331-8,514 ????8,618-8,685 ????5,253-5,675 ????5,775-6,074 ????6,127-6,310 ????6,590-6,773 ????6,874-6,941 |
| ????KS7 ????AT7 ????DH7 ????KR7 ????ACP7 ????KS6 ????AT6 ????DH6 ????KR6 ????ACP6 ????KS5 ????AT5 ????DH5 ????KR5 ????ACP5 | ????3,529-3,954 ????4,059-4,356 ????4,407-4,595 ????4,884-5,063 ????5,163-5,230 ????1,787-2,212 ????2,318-2,617 ????2,670-2,859 ????3,155-3,338 ????3,438-3,505 ????34-460 ????576-875 ????928-1,112 ????1,417-1,596 ????1,696-1,763 |
Structural domain in these extension of module is as shown in table 4 in the position of FscB:
Table 4:FscB
| Structural domain | Amino acid position in FscB (sequence 4) |
| ????KS4 ????AT4 ????DH4 ????KR4 ????ACP4 ????KS3 ????AT3 ????DH3 ????ER3 ????KR3 ????ACP3 | ????3,703-4,103 ????4,247-4,550 ????4,600-4,722 ????5,103-5,286 ????5,389-5,456 ????1,597-2,023 ????2,139-2,442 ????2,494-2,684 ????2,970-3,322 ????3,325-3,508 ????3,610-3,677 |
| ????KS2 ????AT2 ????KR2 ????ACP2 | ????33-460 ????571-874 ????1,224-1,406 ????1,508-1,574 |
FscF coding FR-008 lactonic ring synthetic extension of module 21 and a thioester enzymatic structure territory.
Structural domain in the extension of module is as shown in table 5 in the position of FscF:
Table 5:FscF
| Structural domain | Amino acid position in FscF (sequence 5) |
| ????KS21 ????AT21 ????DH21 ????KR21 ????ACP21 ????TE21 | ????33-456 ????545-851 ????903-1,083 ????1,378-1,561 ????1,668-1,735 ????1,814-2,018 |
Structural domain in these extension of module is as shown in table 6 in the position of FscE:
Table 6:FscE
| Structural domain | Amino acid position in FscE (sequence 6) |
| ????KS20 ????AT20 ????DH20 ????ER20 ????KR20 ????ACP20 ????KS19 | ???5,642-6,069 ???6,158-6,463 ???6,515-6,693 ???7,017-7,322 ???7,330-7,512 ???7,615-7,682 ???4,117-4,544 |
| ????AT19 ????KR19 ????ACP19 ????KS18 ????AT18 ????DH18 ????ER18 ????KR18 ????ACP18 ????KS17 ????AT17 ????DH17 ????ER17 ????KR17 ????ACP17 | ????4,633-4,936 ????5,263-5,445 ????5,552-5,619 ????2,071-2,498 ????2,590-2,896 ????2,948-3,127 ????3,428-3,733 ????3,741-3,924 ????4,025-4,092 ????34-460 ????548-850 ????902-1,081 ????1,384-1,689 ????1,697-1,880 ????1,982-2,049 |
Structural domain in these extension of module is as shown in table 7 in the position of FscD:
Table 7:FscD
| Structural domain | Amino acid position in FscD (sequence 7) |
| ????KS16 ????AT16 ????KR16 ????ACP16 ????KS15 ????AT15 ????KR15 ????ACP15 ????KS14 | ????7,935-8,352 ????8,464-8,767 ????9,099-9,280 ????9,387-9,452 ????6,425-6,845 ????6,935-7,241 ????7,559-7,725 ????7,838-7,898 ????4,872-5,297 |
| ????AT14 ????KR14 ????ACP14 ????KS13 ????AT13 ????KR13 ????ACP13 ????KS12 ????AT12 ????KR12 ????ACP12 ????KS11 ????AT11 ????DH11 ????KR11 ????ACP11 | ????5,408-5,720 ????6,049-6,225 ????6,331-6,398 ????3,342-3,765 ????3,872-4,170 ????4,499-4,676 ????4,782-4,849 ????1,788-2,209 ????2,313-2,621 ????2,972-3,150 ????3,254-3,314 ????38-452 ????563-864 ????921-1,105 ????1,410-1,592 ????1,694-1,760 |
The modifying factor of FR-008 polyketone chain
Except that 6 polyketide synthase genes, in the FR-008 gene cluster, also have 15 coding modifying enzymes, regulate the gene of albumen and translocator.
Table 8 has shown their Nucleotide and aminoacid sequence:
Table 8:
| Open reading frame | Base position in sequence 1 | Amino acid sequence corresponding |
| ????fscTI ????fscTII ????fscRI ????fscRII ????fscRIII ????fscRIV ????fscP | ????26,333-27,340 ????27,561-28,280 ????3,818-3,150 ????7,205-4,377 ????10,320-7,210 ????13,315-10,298 ????16,106-17,287 | ????SEQ?ID?NO：8 ????SEQ?ID?NO：9 ????SEQ?ID?NO：10 ????SEQ?ID?NO：11 ????SEQ?ID?NO：12 ????SEQ?ID?NO：13 ????SEQ?ID?NO：14 |
| ????fscFE ????fscTE ????fscMI ????fscMII ????fscMIII ????fscO ????pabAB ????PabC | ????17,334-17,528 ????17,556-18,413 ????13,522-14,898 ????14,953-16,011 ????137,766-136,558 ????1,950-574 ????18,610-20,781 ????3,037-2,264 | ????SEQ?ID?NO：15 ????SEQ?ID?NO：16 ????SEQ?ID?NO：17 ????SEQ?ID?NO：18 ????SEQ?ID?NO：19 ????SEQ?ID?NO：20 ????SEQ?ID?NO：21 ????SEQ?ID?NO：22 |
The function of each gene in synthetic among the FR-008 is shown in table 9 and table 10 among the streptomycete FR-008:
Table 9:
| Gene | Product | Function |
| ????fscA ????fscB ????fscC ????fscD ????fscE ????fscF | I type polyketide synthase I type polyketide synthase I type polyketide synthase I type polyketide synthase I type polyketide synthase I type polyketide synthase | Starting module and |
Table 10:
| Gene | Product | Function |
| ????fscRI ????fscRII ????fscRIII ????fscRIV ????fscMI ????fscMII ????fscMIII ????fscP | Regulate albumen and regulate albumen adjusting albumen adjusting albumen glucoside transferase GDP-ketose aminopherase GDP-mannose-4,6-dehydratase FscP | The oxidation of the biosynthesis C-18 position methyl of the amino trehalose group of the biosynthesis of adhering to amino trehalose group of the amino trehalose of adjusting |
| ????fscFE ????fscTE ????pabAB ????pabC ????fscTI ????fscTII | Triphosphopyridine nucleotide photoreductase II type thioester enzyme ADC synthetic enzyme ADC lyase abc transport albumin A BC translocator | The outward transport of the outward transport FR-008 of the synthetic FR-008 of the initial unit of synthetic p-aminobenzoic acid of the initial unit of the electronics transfer aberrant intermediate product p-aminobenzoic acid of removal in the P450 MO system |
(ADC is the abbreviation of 4-amino-4-deoxidation chorismate)
The biosynthetic polyketide synthase gene of FR-008
FscA and fscC, fscB, fscF, the transcriptional orientation opposite of fscE and fscD, consistent with 1 condensation step of FR-008 carbochain Synthetic 2, in the fscA-fscF of FR-008 gene cluster gene, there are 21 extension of module to be distributed in their coded polyketide synthases.
FscA albumen comprises a starting module and an extension of module 1 that the FR-008 biosynthesizing is initial, and extension of module 1 comprises the KS-AT-ACP structural domain, at rapamycin, has also found the existence of similar CoL structural domain in pimaricin and the candicidin biological synthesis gene cluster.
FscB has comprised the required extension of module 2-4 of the synthetic step 2-4 of extension of FR-008 carbochain, 3 AT structural domains among the FscB the N-terminal of avtive spot GHSXG all have a RVDVV * * * * * * * M * S (A) * A * * the conserved sequence primitive of W, AT structural domain with this conserved sequence primitive is methylmalonyl specific (mAT), be that it only discerns the substrate methylmalonyl, module 2 comprises KS, mAT, KR and ACP structural domain, module 3 has the reduction ring of a DH-ER-KR, DH4 structural domain in the module 4 has lacked the conserved sequence HPLL of N-terminal and has lacked 56 amino acid at C-terminal, so be non-activity.
FscC and FscD are the huge albumen that comprises 6 extension of module.Long 10,625 amino acid of FscC, long 9,550 amino acid of FscD.The Raps2 that comprises 6 modules in other gene cluster, NysC, NysI, AmphC, AmphI and PIMS2 are stable, but do not find to comprise the polyketide synthase of 7 modules so far, proteic fidelity of 7 modules and continuity are considered to be not enough to be translated accurately.
FscC is responsible for the two keys of synthetic 6 successive (having the two keys of 7 successive in the FR-008 molecular structure), the module 5-10 that is responsible for extension step 5-10 comprises identical DH-KR reduction ring, wherein 6 DH structural domains all have conservative avtive spot primitive G * G * * G * * * A, all AT structural domains all are that malonyl-is specific among the FscC.The most polyene structure of FscC assembling FR-008.
FscD is made up of extension of module 11-16, is responsible for FR-008 carbochain synthetic condensation step 11-16, and the structural domain structure of module 11 is (KS-AT-DH-KR-ACP), last 1 the two key in synthetic 7 two keys.Module 13 has a specific AT structural domain of methylmalonyl, and its structure is KS-mAT-KR-ACP, can extend methylmalonyl CoA extender unit of step 13 integration, module 12,14,15 and 16 all is same KS-AT-KR-ACP structural domain structure, but KR15 be do not have active.Because lack two conservative G residues in conjunction with primitive and the disappearance of ten amino acid arranged at the middle part at the NADP of KR15.The KR of such non-activity can make becomes a carbonyl on the C-15, and then can form the hexa-atomic hemiacetal ring in the FR-008 molecule with the hydroxyl of C-19 position.
FscE albumen is made up of the module 17-20 that is responsible for extension step 17-20, and module 18 and 20 all comprises a complete DH-ER-KR reduction ring, will cause extending step 18 and 20 and is reduced to aliphatic chain fully.DH in the module 17 and ER structural domain are non-activities.The structural domain of module 19 is KS-AT-KR-ACP.Tyrosine in the avtive spot of KR19 is replaced by leucine.
FscF has comprised module 21 and one and has been positioned at C-terminal chain extension terminated thioester enzyme (TE) structural domain.DH structural domain among the FscF does not need in last extension step, and this complete but DH structural domain that do not have function also has discovery at nystatin (NysK) in the polyketide synthase of rifomycin (RifB and RifC) and amphotericin (AmphJ).The KS-AT-KR-ACP structural domain structure of FscF will produce a hydroxyl (OH) in the C-3 position of FR-008 lactonic ring.And also finding to have FR-008 C-3 position is structure (this moment, KR21 the did not have function) existence of ketone group.Illustrate that KR21 is the structural domain of part functionating.Thioester enzymatic structure territory among the FscF makes sophisticated FR-008 polyketone chain fall down and form lactonic ring from polyketide synthase.
Except the thioester enzymatic structure territory among the FscF, also has the fscTE gene of a coding II type thioester enzyme in the upstream of pabAB gene.FscTE has shown the high homology with II type thioester enzyme gene, can remove reactionless active acetate moiety, propionate or butyric acid root on the ACP sulfydryl.
The biosynthetic gene of the initial PABA of unit of FR-008
The product of PabAB and PabC gene is responsible for synthetic para-amino benzoic acid (PABA), and para-amino benzoic acid is the precursor of the synthetic initial unit of FR-008 polyketone aromatic group, and the pabAB in PabAB and other source has very high homology.PabC finds first.PabAB is 4-amino-4-deoxidation chorismate synthetic enzyme, and chorismate and glutaminate are converted into 4-amino-4-deoxidation chorismate and glutamate.PabC is 4-amino-4-deoxidation chorismate lyase, and 4-amino-4-deoxidation chorismate is converted into the para-amino benzoic acid and the pyruvate salt of aromatize.PabAB with show 93% homology from the PabAB of streptomyces griseus IMRU3570, show 46% homology with PabAB from S.venezuelae.The PabC of PabC and Mycobacteriumtuberculosis H37Rv and Pseudomonas aeruginosa PA01 all shows 32% homology.
The gene of regulation domain
4 regulatory gene: fscRI are arranged in the FR-008 gene cluster, and fscRII, fscRIII and fscRIV, their product all belong to LuxR transcriptional regulatory Zijia family.
The adjusting albumen FscRI of fscRI coding is one 222 amino acid whose protein, with the PleR in the deinsectization streptomycete polyene macrolide biological synthesis gene cluster 66% identity (gene library sequence number AB070949) is arranged, 59% identity is arranged with the ORF4 that plays regulating effect in the nystatin biosynthesizing.FscRI also shows homology with the regulon of other two-pack.
May very high homology (in preceding 595 amino acid, 84% identity, but FscRII is than its long 347 amino acid) be arranged to the 595 amino acid whose albumen that candicidin has synthesized regulating effect in the adjusting albumen FscRII (942 amino acid) of fscRII coding and the streptomyces griseus.NysRIII in FscRII and the nystatin (927 amino acid) has 42% identity.
The adjusting albumen FscRIII of fscRIII coding is 1,036 amino acid whose protein, has 34% homology with NysRII (953 amino acid).The adjusting albumen FscRIV (1,005 amino acid) of fscRIV coding has 46% homology with NysRI (966 amino acid), and NysRII and NysRI are the genes that plays positive control in the nystatin gene cluster.
With NysRIII, what NysRII was similar with NysRI is, FscRII, and transcriptional regulatory adjacent with rCO Cytochrome P450 operon among FscRIII and FscRIV and the streptomycete subspecies SA-COO has very high homology.
Polyene antibiotic FR-008 gene cluster comprises very huge polyketide synthase gene (fscC:32kb; FscD:29kb; FscE:23kb), and some of them polyketide synthase gene be corotation record from weave construction between them.This transcribe thereby can be very long.Transcriptional regulatory may participate in keeping the stable of these long mRNA.
Amino trehalose biosynthesizing and adherance because of:
The glycosyl of NMR data presentation FR-008 molecule is amino trehalose.Biosynthesizing that 3 genes (fscMI, fscMII and fscMIII) are responsible for amino trehalose is arranged in the FR-008 gene cluster and adhere to.
FscMI (458 amino acid) and Eukaryotic UDP-glucoside acyltransferase have very high homology, are responsible for amino trehalose the adhering to of C-21 position on the FR-008 aglucon.FscMII (352 amino acid) and 4, the transaminase during 6-dideoxy-4-epichitosamine is synthetic is similar.FscMIII of fscMIII genes encoding (402 amino acid) and GDP-seminose-4, the 6-dehydratase is similar.Amino trehalose (3,6-dideoxy-3-amino-D-seminose) biosynthetic pathway comprises coming the GDP-seminose in the autonomous metabolism to be converted into GDP-4-ketone group-6-deoxidation-D-seminose under the effect of GDP-seminose dehydratase, isomery turns to GDP-3-ketone group-6-deoxidation-D-seminose then, and the transamination by GDP-ketose transaminase at last forms the amino trehalose of GDP-.Wherein isomerization does not need the participation of enzyme.FscMIII and FscMII are responsible for the dehydration and the transamination of this biosynthetic pathway respectively.
When gene library is searched for, FscMI and AmphDI have 54.7% identity, with NysDI 52.4% identity are arranged, and with PimK 60.5% identity are arranged.FscMII and CanA have 92% identity, and with AmphDII, NysDII and PimC have the identity of 74-76% respectively.FscMIII and AmphDIII (66%), NysDIII (67%) and PimJ (69%) have very high identity.Above-mentioned enzyme all is considered to be responsible for amphotericin (AmphDI, AmphDII and AmphDIII), nystatin (NysDI, NysDII and NysDIII), the biosynthesizing of amino trehalose in pimaricin (PimK, PimC and PimJ) or candicidin (CanA) molecule.This also meets FscMI, and FscMII and FscMIII are responsible for amino trehalose biosynthesizing and the function of adhering in the FR-008 gene cluster.
Modify and transporter gene:
The specific AT13 of methylmalonyl (acyltransferase structural domain) that is responsible among the FR-008 polyketone chain synthetic polyketide synthase FscD extends propionic acid residue of importing in the step at the 13rd, thereby forms a methyl chains in the C-18 position of FR-008 molecule.FscP FscP (393 amino acid) is responsible for the methyl chains of C-18 position is oxidized to carboxylic group.A little acidic protein of fscFE genes encoding (64 amino acid) in next-door neighbour fscP downstream is the Triphosphopyridine nucleotide photoreductase that contains iron-sulifide protein bunch ([3Fe-4S]).It becomes the part of P450 mono-oxygenase system as an electron transfer protein.The homology of the FscP PimG demonstration 81% of modifying behind FscP and the responsible pimaricin and 69% identity, with the homology of the FscP NysN demonstration 77% of modifying behind the responsibility system Mycinomycin II and 66% identity, with the homology of the FscP AmphN demonstration 76% of modifying behind the responsible amphotericin and 66% identity, show 94% homology with the FscP of modifying behind the responsible candicidin.
The module of being responsible among the FR-008 polyketone chain synthetic polyketide synthase FscE 18 is KS-AT-DH-ER-KR-ACP structures that comprise the full backup ring, thereby extends at the 18th and to be reduced into aliphatic chain fully in the step and not have group in the C-9 position.The mono-oxygenase (FscO) of the coded dependence of fscO FAD is responsible for modifying and the introducing hydroxyl in the C-9 position.This with amphotericin and nystatin after modify also be responsible in the hydroxylation by FscP different.The homology of the mono-oxygenase demonstration 34% of the dependence FAD among FscO and the Agrobacterium tumefaciens C58 and 25% identity.The same with KR21, fscO also is that part is active, therefore has C-9 position hydroxylation and not hydroxylated two kinds of structures to exist jointly in the FR-008 mixture.
The sequence of FR-008 gene cluster and candicidin gene cluster relatively
FR-008 contain one with identical seven alkene macrolide aglucons that contain the 4-aminoacetophenone of candicidin D in the streptomyces griseus, there are the pHZ227 of 130kb and two linear plasmids of pHZ228 of 30kb among the streptomycete FR-008, but producing bacterium streptomyces griseus IMRU3570, candicidin do not have linear plasmid, streptomycete FR-008 produces the very good and streptomyces griseus IMRU3570 of spore, and to produce spore very poor, because FR-008 has similar structure with candicidin D, so responsible sequence of synthesizing them has very high homology probably, the candicidin biological synthesis gene cluster has only partial sequence to assert (totally 39, the sequence of 314bp), FR-008 gene cluster (sequence 1, totally 138, corresponding sequence and this 39 203bp), the contrast of 314bp sequence finds between them very high homology is arranged, base 5 in the FR-008 gene cluster (sequence 1), 421 to 44,805 (the KS structural domains from fscRII to fscB module 4) with this 39, the 314bp sequence has the 98-99% homology except that some little intervening sequences, these intervening sequences do not have tangible homology in two sequences.
Table 11 has shown the contrast of these two sections sequences:
Table 11:
| Homology (%) | The FR-008 sequence is initial | The FR-008 sequence stops | The candicidin sequence is initial | The candicidin sequence stops |
| ??98.73 ??99.10 ??98.19 ??99.17 ??99.76 ??98.54 ??99.33 ??100.00 ??99.47 ??99.06 ??98.88 ??95.52 ??98.80 ??99.59 ??98.10 ??95.65 | ????1 ????604 ????2108 ????2337 ????2747 ????3226 ????5406 ????7872 ????8068 ????13025 ????15422 ????18576 ????18937 ????20954 ????21974 ????23503 | ????550 ????2048 ????2273 ????2698 ????3171 ????5344 ????7808 ????8000 ????12962 ????15365 ????18553 ????18839 ????20929 ????21930 ????39384 ????23548 | ????2 ????605 ????2109 ????2338 ????2748 ????3227 ????5398 ????7865 ????8061 ????13026 ????15423 ????18576 ????18852 ????20870 ????21890 ????23460 | ????551 ????2049 ????2274 ????2699 ????3172 ????5336 ????7801 ????7993 ????12963 ????15366 ????18553 ????18843 ????20845 ????21846 ????39314 ????23415 |
Table 12 has shown intervening sequence and their positions in two gene clusters.
Table 12:
| Intervening sequence | Base position in the | Position in the position candicidin sequence in the FR-008 sequence |
| ?????52bp ?????58bp ?????62bp ?????47bp ?????53bp ?????60bp ?????62bp ?????61bp ?????55bp ?????21bp ?????9bp ?????23bp ?????42bp | ??552-604 ??2050-2108 ??2275-2337 ??2700-2747 ??3173-3226 ??5337-5397 ??7802-7864 ??12964-13025 ??15367-15422 ??18554-18575 ??18842-18851 ??20846-20869 ??21847-21889 | KS1 domain KS domain fscTI canRA fscTII canRB among the KS1 domain KS domain fscA among fscRII orf1 fscRIII orf2 fscRIII orf2 fscRIII orf2 fscRIII orf2 fscRIV orf3 fscRIV orf3 fscTE canT pabAB and the polyketide synthase gene intervening sequence fscA |
Show that more than FR-008 and candicidin gene cluster derive from very close ancestors.
Following application example has been illustrated the preferred approach that obtains and use sequence provided by the present invention and key element.These examples just are used as explanation and do not limit range of application of the present invention.By some gene orders in the genetically engineered molecule manipulation gene cluster, can obtain the deutero-engineering strain that sequence changes, or utilize sequence of the present invention to obtain carrying the dna fragmentation of FR-008 biosynthesis gene.
Application example 1:
80kb sequence in the deletion sequence 1
1, (base 2 in the sequence 1 for 518bp BglII-BamHI fragment, 293-3,810) and 4, (base 83 in the sequence 1,766-87 for 075bp BamHI-BglII fragment, 840) be selected to two arms as gene substitution and come in the missing gene bunch 79, the sequence of 955bp (in the sequence 13,811-83,765).This 79, the 955bp sequence be from the fscRI sequence to fscF the pairing sequence of KS21 structural domain of module 11.1, the 518bp fragment is to reclaim from pHZ145, and 4, the 075bp fragment is to reclaim from pHZ144.They all are used to carry out homologous recombination with the FR-008 chromosomal DNA.In the middle of these two fragments, insert an apramycin resistant gene, then the structure that obtains is cloned into pIJ903 and obtains gene substitution plasmid pHZ2029.By conjugal transfer pHZ2029 being imported streptomycete FR-008 takes place to obtain the gene substitution bacterial strain after the double exchange.Verified the generation of double exchange by Southern hybridization.Disappearing by the about 300kb VspI of karyomit(e) fragment in the high-voltage pulse electrophoresis discovery gene substitution bacterial strain has in addition produced the new segment of a 220kb, and the about 80kb sequence that is presented at the KS21 structural domain of FR-008 gene cluster from fscRI to fscF module 11 in this gene substitution bacterial strain is removed.The biosynthesizing of FR-008 has been blocked in this gene substitution bacterial strain.Find having lost of cereuisiae fermentum suppressed active by detecting.
This gene substitution display separation to sequence (sequence 1) be that to be responsible for the FR-008 microbiotic biosynthetic really.
Application example 2:
Disappearance polyketide synthase gene order
The downstream comprises the fscA (20,927-26,158) of polyketide synthase gene order, fscC (60,860-28,983), fscB (77,587-60,962), fscF (84,132-77,983), fscE (107,485-84,170), fscD (137,148-107,496) is responsible for the biosynthesizing of FR-008 aglucon.Two abc transport albumen are arranged between fscA and fscC, and (fscTI, fscTII), they comprise the base 26,333 to 28,280 in the sequence 1.Library plasmid pHZ119 has carried the polyketide synthase sequence that pabAB gene order and downstream thereof comprise these two abc transporter genes.After pHZ119 BglII enzyme is cut two BglII fragments on it are replaced as escherichia coli plasmid pDH5.These two BglII fragment codings the ATP dependency Carboxylic acid from fscA: coenzyme ligase enzyme structural domain (CoL) is to the ACP9 structural domain (comprising fscTI and fscTII) of fseC module 9.Resulting plasmid is used to carry out gene substitution.Take place after the double exchange, on the wild-type FR-008 karyomit(e) in the sequence 1 base 21,537 to 36,847 replaced by the pDH5 sequence.Double exchange is confirmed by Southern hybridization.The biological activity determination experiment finds that the FR-008 biosynthesizing of double exchange bacterial strain is blocked.This shows on streptomycete FR-008 karyomit(e) ATP dependency Carboxylic acid from fscA: after coenzyme ligase enzyme structural domain (CoL) was replaced by the pDH5 sequence to the pairing sequence of ACP9 structural domain of fscC module 9, the antibiotic biosynthesizing of FR-008 was blocked.These sequences are proved to be that biosynthesizing is essential to FR-008.
Application example 3:
PHZ168 carrier sequence is inserted in the polyketide synthase sequence in the sequence 1
There is one 1, the ACP6 structural domain in 424bp BamHI fragment (base 50,488 to 51,911 in the sequence 1) the coding fscC module 6.By the BamHI enzyme cut back to close comprise on the pHZ137 this 1, the dna fragmentation of 424bp sequence is cloned on the pHZ168.PHZ168 is the plasmid of deriving of pDH5, and comprises the oriT (conjugal transfer initiation site) among the RK2.Resulting gene interrupt structure imports among the streptomycete FR-008 by conjugal transfer.Because of pHZ168 does not have the streptomycete replicon, it and it carry 1, the segmental derived structure of 424bp reproducible not in streptomycete FR-008.This gene interrupt structure has only by it identical with karyomit(e) 1, the 424bp sequence homology just reproducible of recombinating on the streptomycete FR-008 karyomit(e).Gene interrupts bacterial strain and is obtained by the separation of success.These genes interrupt mutant strain and inserted pHZ168 in the biosynthetic polyketide synthase dna sequence dnas of responsible FR-008.Or rather, pHZ168 carrier sequence is inserted in the ACP6 structural domain sequence of fscC module 6.The FR-008 biosynthesizing that biological activity determination shows these mutant strains is blocked because of the insertion of pHZ168.
Application example 2 and 3 shows that all polyketide synthase gene provided by the present invention is responsible for the synthetic of FR-008 lactonic ring.Because corresponding condensation step of each polyketide synthase module, thereby the lactonic ring molecular structure of corresponding FR-008, this provides one to transform polyketide synthase gene order among the streptomycete FR-008 and obtain the new antibiotic approach of the corresponding lactonic ring structural modification of FR-008 microbiotic.This new microbiotic may have the anti-microbial activity raising or antimicrobial spectrum changes or the characteristic of chemistry of antibiotics characteristic changing or chemical toxicity change, thereby improves the scope of industrial economic benefit of microbiotic or expansion clinical application.
Application example 4:
Disappearance modifying factor sequence
PabAB and pabC gene may participate in the biosynthesizing of initial unit para-amino benzoic acid in the FR-008 assembling.In the pabAB upstream, 9 modifying factors and regulatory gene are arranged.With remove pabAB downstream 15 on the FR-008 karyomit(e) in the application example 2,311bp polyketide synthase sequence method is similar, will comprise 19 of base 2,293 to 21,536 in the sequence 1 on the pHZ138, the BglII fragment of 244bp is replaced as pDH5.By the gene substitution experiment, comprise part pabC on the streptomycete FR-008 karyomit(e) up to 19 of pabAB gene, the 244bp sequence is replaced by pDH5 carrier sequence.Biological activity determination shows that the biosynthesizing of FR-008 seven alkene macrolides in the gene substitution bacterial strain is blocked.
And, 1,518bp BglII-BamHI fragment and 4, the also selected gene substitution plasmid that makes up of 290bp BamHI-BglIII fragment is to remove their centres 13, the sequence of 436bp.This 13, the sequence encoding part fscRI gene of 436bp is to the pabAB gene.Between these two fragments, insert the apramycin resistant gene and be cloned on the suicide vector pHZ660.After the double exchange on the streptomycete FR-008 karyomit(e) this 13, the 436bp sequence is substituted by the apramycin resistant gene.Hybridize the generation of having proved conclusively double exchange by Southern, resulting gene substitution derivative strain can not produce the FR-008 microbiotic, shows that these modifying factors and regulatory gene are that the FR-008 biosynthesizing is necessary.
This provides modification gene sequence among the transformation streptomycete FR-008 and has obtained the new antibiotic approach that FR-008 microbiotic corresponding construction changes.Modifying enzyme makes the corresponding construction of lactonic ring be modified by the lactonic ring that acts on FR-008.The formed methyl of FscP oxidative condensation step 13 becomes carboxyl, and FscO adds hydroxyl in the C-9 position.For example interrupt or disappearance FscP gene and to obtain the C-18 position be methyl but not the FR-008 antibiotic derivatives of carboxyl; Or interrupt or disappearance FscO and obtain the FR-008 antibiotic derivatives that the C-9 position does not have hydroxyl; Or interrupt simultaneously or lack two even three modifying factors and obtain corresponding FR-008 antibiotic derivatives.Can also change the modification gene of external source over to and obtain the FR-008 antibiotic derivatives that corresponding construction changes.All these new FR-008 antibiotic derivatives may have the anti-microbial activity raising or antimicrobial spectrum changes or the characteristic of chemistry of antibiotics characteristic changing or chemical toxicity change, thereby improve the scope of industrial economic benefit of microbiotic or expansion clinical application.
Similar, with 5, (base 5 in the sequence 1 for 069bp BamHI fragment, 090 to 10,159) and 4, (base 17 in the sequence 1 for the 290bpBamHI-BglII fragment, 247 to 21,537) as the fragment of homologous recombination, in the sequence 1 from base 5,091 to 17,246 coding fscRIV, fscMI, fscMII, fscP and part fscRIII sequence are replaced by the apramycin resistant gene.Biological activity determination shows that these gene substitution bacterial strain derivative strains can not produce the FR-008 microbiotic.This 7, the 088bp sequence is that the FR-008 biosynthesizing is essential.
Application example 5:
Disappearance regulatory gene sequence
Utilize streptomycete FR-008 library coemid pHZ138 last 1,518bp BglII-BamHI fragment and 7,088bp BamHI fragment is integrated fragment as homology, be cloned on the pHZ1358 (thiostrepton resistance) with the direction identical with the natural dyeing body, apramycin/erythromycin resistance gene has been inserted in the centre, obtains pHZ2007.PHZ2007 is imported among the streptomycete FR-008 conjugal transfer of thiostrepton sensitivity by anti-selection screening apramycin/erythromycin resistance by conjugal transfer.With 1.5kb and 1.9kb and apramycin/erythromycin resistance gene fragment is that the hybrid experiment of probe shows (Fig. 4), the apramycin that is screened/erythromycin resistance and conjugal transfer (gene substitution bacterial strain bacterial strain) of thiostrepton sensitivity has all lacked coding fscRII, 6 of fscRIII and part fscRI, (base 3 in the sequence 1 for the 414bp sequence, 811 to 10,158) substituted by apramycin/erythromycin resistance gene.The sequence of this Regional Representative's regulatory gene.Biological assay shows that the biosynthesizing of FR-008 in the mutant strain of sequence deletion of regulatory gene is blocked (Fig. 5).Show that biosynthesizing is essential to these regulatory gene to FR-008.
Application example 6:
Lack initial unit para-amino benzoic acid synthetic gene sequence
From pHZ145, reclaim the BamHI fragment of the 4.6kb that carries para-amino benzoic acid synthetic gene pabAB, be cloned on the suicide vector pOJ260, cut from connecting in the disappearance external source fragment between the FspI restriction enzyme site 1 by the FspI enzyme, the fragment of 491bp has promptly lacked 497 amino acid whose sequences of pabAB gene inside with frame.The gene substitution plasmid that obtains is imported among the streptomycete FR-008 by conjugal transfer, screen the pabAB genetically deficient 1 that expection has taken place, the mutant strain of 491bp also passes through the hybridization checking.Fail to detect the synthetic of FR-008 in the mutant strain.Illustrate to lack para-amino benzoic acid, the biosynthesizing of FR-008 can not be initial.Add the external para-amino benzoic acid of 0.3M in substratum, mutant strain has recovered the generation of FR-008 again.The selection of the initial unit of biosynthesizing of FR-008 is very special.
Application example 7:
The existence of two cis-double bondss in the prediction FR-008 molecule
Keto reductase structural domain in polyketide synthase and the animal tallow acid enzyme has been formed a subfamily in the SDR reductase enzyme Superfamily.In the polyketide synthase keto reductase structural domain (KR) be responsible for the steric configuration of synthetic carbochain, and the control of this steric configuration is to finish by the aspartic acid of a specific site in the keto reductase structural domain.This aspartic acid be considered to the keto reductase structural domain in 112 Histidine and 100 s' tyrosine control jointly the steric configuration of synthetic carbochain.When this specific amino acids is aspartic acid (D), ketone group is reduced into the hydroxyl of D configuration; When this specific amino acids is amino acid beyond the aspartic acid, ketone group is reduced into the hydroxyl of L configuration.In the reduction of all ketone group, dehydration and forming in the reaction of trans double bond, catalysis ketone group reductive keto reductase structural domain all has this specific aspartic acid.On the contrary, in the reduction of all ketone group, dehydration and forming in the reaction of cis-double bonds, catalysis ketone group reductive keto reductase structural domain all lacks this specific aspartic acid or this specific aspartic acid changes.And the keto reductase structural domain this to the control of steric configuration of synthetic carbochain do not rely on other enzyme or substrate or enzymatic environment.This specific amino acids that the FR-008 polyketide synthase is responsible for keto reductase structural domain KR8 in conjugated double bond synthetic polyketide synthase module 8 and the module 9 and KR9 be respectively glycine (G) and N (N) rather than aspartic acid (D) (Fig. 6), so the two keys of their responsible synthetic of institute are cis-double bonds.Be that the two keys between C28-C29 and the C30-C31 are cis-double bondss in the FR-008 molecule.
Application example 8:
The direction that glycosyl adheres in the prediction FR-008 molecule
In the polyketide synthase keto reductase structural domain (KR) be responsible for the steric configuration of synthetic carbochain, and the control of this steric configuration is finished by the amino acid of a specific site in the keto reductase structural domain.When this specific amino acids is aspartic acid (D), ketone group is reduced into the hydroxyl of D configuration; When this specific amino acids is amino acid beyond the aspartic acid, ketone group is reduced into the hydroxyl of L configuration.And the keto reductase structural domain this to the control of steric configuration of synthetic carbochain do not rely on other enzyme or substrate or enzymatic environment.This specific amino acids that the FR-008 polyketide synthase is responsible for the keto reductase structural domain KR12 in the polyketide synthase module 12 that C-21 position hydroxyl forms be L-Ala (A) rather than aspartic acid (D) (Fig. 6), so its institute's responsible synthetic C-21 position hydroxyl is the L configuration.And this C-21 position hydroxyl is the site of glycosylation, has determined glycosyl to be positioned at the reverse side of FR-008 lactonic ring.Other glycosyl that carries the polyene macrolide of amino trehalose also all is positioned at the reverse side of macrolide ring.
Application example 9:
From streptomycete FR-008 library, angle and get the new coemid that carries the FR-008 biosynthesis gene
The sequencing of coemid pHZ194 finds that it is the coemid of a reorganization, and two carrier pHZ132 and unknown a source and the irrelevant dna fragmentation of FR-008 biosynthesizing are arranged.This may be the result of DNA reorganization in the library construction process.
The sequence of coemid pHZ194 does not also cover FR-008 biological synthesis gene cluster completely.Get the new coemid that carries the FR-008 biosynthesis gene in order from streptomycete FR-008 library, to angle, the sequence relevant (sequence 1, polyketide synthase sequence) design PCR (polymerase chain reaction) primer with the low order end of coemid pHZ194 with the FR-008 biosynthesizing.
Designed PCR primer sequence is as follows:
CS1(5′-TGCCGCGCTCGCCGACA-3′)
CS2(5′-CGCGTCCGGTGCTCACG-3′)
Wherein the sequence of CS1 is to come from 118 in the sequence 1 of the present invention, 479-118, and 463, the sequence of CS2 is to come from 118 in the sequence 1 of the present invention, 262-118,278.With these two PCR primers based on sequence 1 design, be substrate with coemid pHZ194, successfully amplified the dna fragmentation of about 200bp.
The PCR condition is as follows:
0.1 μ g substrate DNA, two each 50pmol of primer, 2.5 μ l DMSO and 25 μ l high-fidelity PCR mixtures (High Fidelity PCR Master, Roche Holding Ag) add aseptic ultrapure water to 50 μ l.The PCR instrument is the PCR Thermal Cycler MP TP3000 of Japanese Takara Shuzo Co. company.The cycling condition of PCR reaction is 95 ℃ (5 minutes), 30 95 ℃ of round-robin (30 seconds), 65 ℃ (30 seconds) and 72 ℃ (30 seconds), be at last 72 ℃ 7 minutes.
Sequencing shows that the sequence of this about 200bp dna fragmentation comes from 118 in the sequence 1 of the present invention really, 479-118, and 262 are total to the sequence of 218bp.
Carry 118 in the sequence 1 with this, 479-118,262 218bp dna fragmentation is a probe, with the hybridization of streptomycete FR-008 gene library, angles out two coemid pJTU1 and pJTU2.These two coemids and pHZ194 are overlapping and carry this 218bp dna fragmentation.Sequencing shows that coemid pJTU1 (as Fig. 1) has carried the biosynthetic gene of responsible FR-008.Coemid pJTU1 external source fragments sequence has constituted 118 in the sequence 1 of the present invention, 480-138,203 sequence.
Following content according to the present invention provides gene order (seeing down one page for details).
SEQUENCE?LISTING
＜110〉Shanghai Communications University
The high scientific and technical institute of Korea S (Korea Advanced Institute of Science and Technology)
＜120〉be responsible for the biosynthetic gene cluster of FR-008 polyketone antibiotic
<160>22
<170>PatentIn?version?3.1
<210>1
<211>138203
<212>DNA
＜213〉streptomycete FR-008
<400>1
ccaatggcga?gatggccggg?ggagtacggc?atgagggccg?gggggcacga?tggggggcgg?????60
cgatcgtggc?gggagggacc?cagcgggggg?gtcgtacctg?ttccacgcgg?ggcgcacggc????120
acggggcgcc?tggtgggggg?acgagacgtc?cgtggggaag?gaggcgtacg?tcgaccgctt????180
caccgcgctg?taggggctct?cccgcgaaac?ggcgcgagac?cgagtgtttc?agcggccgga????240
tcgacgcgga?ccggctgacg?cggctgctga?ccctgttggg?cgcccggccc?ggccccggga????300
cccggttcgc?ggtgtgcgga?ccgtacggcc?tggtggagac?ggtccgctcc?acgctcgacg????360
ggtggggggc?cgagccggac?accgtccgtt?tcgagctgtt?ctccaccgac?ggggcaccgc????420
cggagccgga?gcccgaggcg?cccgccgtcc?gcaggggccg?ggtcaccacc?gtgctcgccg????480
ggcgcaccgg?cacggtgacg?acggcaccgg?aggacaccac?gctcctcgac?accgtgctgc????540
ggtgccgcgc?ccactcacgt?acgaggtcct?cggttacctg?gacttcaggc?tgtgtccgcc????600
gaagccgctg?cgccggtcgg?agccgttgtt?ctgctcctgc?caccacgcgt?cgaactcggc????660
ctggcccatc?gcggaccagt?cgggggtctc?ctcgacctgg?gcactgccca?tccggcgggc????720
gagtcccacc?atggccgtgc?cgacgggacc?ccgagccgcg?tggtacccct?ccaggatctc????780
cttccagctc?tccccggcca?cccaggcggc?ttccagcgcg?gtggcgtcct?ggagtgcctt????840
cacactgccg?gcgccgaggt?gcggccgggc?cacgctcgcg?gcgtccccga?tgagcaccat????900
ccggtcggtg?gcgtagtgcg?gcacgtccag?gtcgtagatg?ggctggatga?aggtggtctc????960
ggccggggtg?gagaggagct?tggcggccca?gaagggcggg?aagtgctctg?ccaccagggc???1020
gcgcaggtgc?tccgtcagtt?ccgcgttgag?ccggcccggc?ggcagggagg?tgggggtccg???1080
caggtcgggg?tggaggccgt?cgatccgcgg?gggtgccgtg?tagagcaccc?agttgaggcg???1140
gtggccgccg?gagccgtccg?ggatgcggta?ggccatgcag?tggccgccgg?ggaaggtgat???1200
gttgtgcgcg?tcgagcccgt?ccgagggaag?accggagacg?tccggggagg?tcccgcgcca???1260
gccgatgtag?ccggcgtacg?cggcgccggt?gcccgggtac?atggcctcac?ggacgacgga???1320
gcggtagccg?tcggcgccta?tgaccaggtc?gaagcgttcc?ggctcgccgt?cggcgagacg???1380
taccgtgacc?ccgtcggcgt?cctgctccac?cgcttccacc?ttggcgcctg?cccgataggt???1440
ggcggtctcg?ggcacccggc?ggcgcaactc?gctccacagc?gaaccccagt?tgtaggcccg???1500
gaaggggaac?ggctgggtgc?cgatggctct?gccgtgctcg?gcgtcgccgt?cgcgcacgct???1560
ccacaccctg?cggttcagcg?gcgcccacgg?catctcgtcc?gccatgtaac?cggcgtcgcg???1620
cagttcggcg?taccgggcgt?cgtggacacc?gatgcccact?cccctgtcgc?ggagtcgcgc???1680
gtcggcgcgt?tcgaagacgg?tgatcctctc?cgccccgccg?cgcgacgccg?ccaatgcggc???1740
ggcgcatccc?gcgatactgc?cgccgacgac?ggcgacactg?cctccacgca?tactgactct???1800
ccacttcttc?gcgtgctggt?gccctttccg?gactttcccg?caggggcgcg?tcggaacggc???1860
gatccgccgt?ccccgacttg?tccgcccttt?cctgcggtga?ggacacccgc?gaaaccctat???1920
cgaggtgggt?gccgggcatg?tcgagggcat?tcgccggtcc?gtcaggccgc?cctggacgca???1980
ggcgtatacg?cggggcctgg?cgcattcacc?gttcccggcg?cggaagggcc?ggcctctccg???2040
gaccgtacac?acggttcgcg?acgccgcgat?gcacacgaga?tcatttcttc?ccgcatccgc???2100
tttccccaca?tgccgtgcag?ggaaatgtcc?gggtgctgcc?gaaaaggaga?gcgggtgggc???2160
gaatggcgaa?tgccgggcgg?catggaggaa?atgggcgatc?gaccgtccgc?ccgaggactc???2220
ctgcgcgagc?ggcggaacgg?agcgccccgg?cgccgccgcc?ccgtcagagc?ggggagccgg???2280
gaagtgcctg?gtagatctcc?gcgagccggg?tcaccgagtg?atgggccgcc?gggaactcac???2340
ggtcgtcgat?gccggtgacg?ggacggaccc?cgacgcggcg?ttggtcgcga?agaccgcctc???2400
gactgagtcg?aggtccgcga?ggccgaccag?ttcggtggga?ccgtcggtgg?ccccgccgca???2460
gcagctgccg?ggtcgtgccg?gccagcacct?ccccgccggg?ccagaccacc?tcgccgtcgc???2520
gcaccaggcc?gacgttccag?gtgccgccct?ccaggatgtc?gccgtcgggg?cccgtgaaca???2580
gcacgtcgtc?gtaacccgcc?cgttgggcct?gcctgcgcag?ccgcagggtg?ggacagaggc???2640
cgaccgactt?cacctcggga?aggtcgcggc?ggtggaccac?cgaacgt1cc?cgcagcggac???2700
cagggggctt?gtcgggggcg?ggccgggagg?tcaccaggat?gcccggccgg?gcgtcggcgg???2760
cgatgttccc?caggttcagc?gccgggtcga?agacggtgac?acggacggtg?gcccggccgt???2820
ctgttggtgc?cgcccggcgg?gcgagcttcc?gcacccggtc?cgggtcgagc?gccgcgtcga???2880
agagggtccg?gcagtcgcgg?atgaggcgtt?ccaggtggag?gtcgagcccg?cgcacccggc???2940
cgttctcgac?gagcagcgtg?gtgaaatggc?cgtagttggt?gagggcgagc?gaggccagcg???3000
cctcgggccc?ggcgggttcc?ccgtccagtt?cgatcatgac?gtcaccctgt?cactgtgacc???3060
gccgtaccgt?gcgcggagcg?cgcgacgggg?acgagcgggg?gtgcggaccg?gcggccgggc???3120
tgccgccggc?ggggcacacg?gtgtacggat?cacttgatga?agtcctcgac?gaccttcggc???3180
ggccaggtgc?cgaccttgag?gacgcccatg?gagtaggcgc?gggagacgag?agcggcacgg???3240
ttgggcacct?tgagcttccg?cagcagcccg?gtgacgtggt?actccacgcc?ctggcggctg???3300
aggtagaggc?gggaggcgag?cgggatggtc?gagaccccgg?cggctatgcc?ctccaggatg???3360
cgtgcgtcga?tctcgctgag?gagcttcttg?cggggcgcca?tgacgtccgc?gtccccggcc???3420
tcctcctccg?cggcgttcat?caccacgagg?atcgcggcca?cgtcgggcgt?acggccaccg???3480
cgtaccgcga?gcgcgttcag?cggcagcgtg?gacgccgtgc?gttcctggtc?gaccgcgatg???3540
acctcggtgg?cgaagcggtg?ccgcttgccg?tccagcatcc?gcgcgaactg?gtgcatgagg???3600
ggctgctgga?cgctcgggtg?gacgaggtcg?cagaagcggc?tgccgcagag?ttcggaggac???3660
gagccgccga?agcggcgctc?gaactcctgg?ttgacctgct?ggatcgtgag?agacgggtcg???3720
aggcaggcga?cataggcacc?ggcccggtcg?aacccgtccg?cgagaacggc?ggcccgttcc???3780
ggcgagccgg?ccgggtcggc?cgccggcgcg?ggatccatga?gcgtgctgtg?gggggtggcg???3840
ggcatcaagg?aactcataac?ctttcatcgt?ttcgcattac?gggggtgggg?tggcgcggcc???3900
cgcgctcagg?aaaaggcgac?cgcgcccagg?gcccttgagt?aagggccagc?gacgagaaag???3960
aagatgtttt?ggatcctacg?aaagcggcta?tcggcggtca?acgcggtcca?gggctgaccg???4020
gccaatactg?tggtagcccc?ttcggtaggt?acggtcccgt?accgaagagg?ttcgggcggg???4080
gagggttcgg?tgtgcgtacc?tcaccgcccc?gcaccgcgtc?cacctgcgaa?gaagggtcga???4140
actcgggcgc?cgttccccgc?cccgggggcc?ggacggccct?agccgtcccc?gcaccgtggc???4200
cccgcacacc?gcggaaatgg?tgacgaacgt?tcatccagat?ttcccggccc?ggggcgcaaa???4260
cgacattctg?ggggacgccg?gatgtcctgg?ccgcaccatg?gccggaaaac?aaggacgccc???4320
ggggtccttc?cgcgaatatg?cggcggaagg?agcccgggcg?tttccctcgg?cgcgtatcag???4380
tcgccggtgc?cggcgtattc?cgcgcgggag?aagaggacga?tcagttcccg?gcggccggag???4440
atgcccaggc?gccggtaggc?gtgggtcagg?tgcttctcca?cggcgcgcga?gctgaccccg???4500
agggcgccgg?cgatctcctg?gttggtcagc?ccccggcagg?ccagccccac?cacgcggcgc???4560
tcggtcgggg?tgagcacgtc?ctccggtgtg?gccggcgggc?cggagcgatg?accggcaccc???4620
cgggccgccc?gttcggccag?cccgggggcg?ccgcacgagg?tggccagggt?ggcggcctcc???4680
cgggcgagcg?cctcggtctc?ggcgccgccg?cccaggcgtt?cggcgagggt?ggacagggcg???4740
cgggccagtt?cgagctggtt?ggcggagcca?cgcagcacgg?tgacggcctc?gcgcagcaga???4800
ccgatgcccc?ggccgccgtc?ctccaggcgg?ccgagcagcc?gcagcgcgcg?gcccaccccg???4860
acgggggcgc?cccactgctc?ggcccgcgcg?tactcctcct?cggcgaggct?ccgggcggtg???4920
cggatgtcac?ccaggcggcg?gtggacgccg?acggcccagg?ggcgccaggg?gaagagcacc???4980
gggttgtgcc?agccggcggc?ttcgagctgg?cggccgcagg?agtgcagcga?gtcgagggct???5040
ccggtctggt?cgcccgcggc?gatctcccgg?gtggcctcca?gcaggcgcag?gatcccggtg???5100
agggtcaggc?cctgcggcct?gatgcggctc?gcgcgccgca?gcaccttctc?ggcgagcgag???5160
gggtcgcggg?actccagcgc?gacgatcgcg?tgcgtcatcg?tcgccgcggt?gtccaggccc???5220
tggtgggcgg?gctccgtcat?cccgagggcc?gtctcggact?gctcgcgggc?ctgggcgagc???5280
cggccgcgcc?cgaggtggac?gagggcctgc?tcgatgtgga?ccagggcgtt?ggcgggggtg???5340
gtaccccgct?cgttggcacg?gtgctcgacg?gcgagccagg?agtcgacggc?ctccaccgag???5400
tcggcggcga?tcatcgtgat?gatcgccagc?gggagggtgg?agtggatgcg?ggcggaggtg???5460
gcgggctcgc?ggtccaggac?gcgcccggcg?aggcgcacca?cctcggaggc?gggcaggtga???5520
cagccgaggg?tcgcggcacc?gagcagcgcg?atcgtcagct?cccgctcgcc?tccggtgtcc???5580
accgggggct?cggggcccag?ttccttcaac?cggtgcgccg?aggcggcgag?ttcgtggggg???5640
tcctcgtggc?cgcagtggcg?cagcctggct?tccagacgga?gcgcgagatc?gcggtcggtg???5700
ccggtgagcc?cgtcggcggg?cccgaggtcc?tcggcggcct?ggcgcagcag?gtcgacggcg???5760
gtgagcgggg?cggggcccag?cgcggtcggg?gagatgcgca?gggcggcgac?ggcccggtcc???5820
cgtggttcgg?ggagcagggt?catggcctgg?gcgatgtggc?gttcgcaggc?gagtgggtcg???5880
aaccctctct?ccgcggtgcc?cagttcgacg?aggaggcggc?cgcggccgac?gccggcggcg???5940
gggctgtcca?gcagggcgcg?gcacaggtag?ccggcggcgg?tgtcgggggc?gccgcggcgc???6000
agcgcggtgt?cggcggcggc?gcgcaggacg?tcgacggccc?acggctggcg?ccgggtgacg???6060
acggccatga?gctgggcggc?gacctgttcg?gccggggagc?cggcggcgta?gaggagggcg???6120
gcggcctcgt?cgtgcatccg?ctcccgctgg?accatggtga?gggtggactc?ggcggcgtcg???6180
cggacggacc?ggtggatgaa?gcgcggttcg?tcgggggcgg?cgagggcgcc?gagcgcgccg???6240
agggcgcgca?gggcccccgc?gtagccgatc?gagtcgagcc?cggccagccg?ggccagggtg???6300
ggcgcgtcgc?tctgttcgcc?gaggatggcg?atggcggcgg?cgaggtcgcg?gaccggggcc???6360
ggctgggtgc?gcaggatgct?ggcgagccgt?tcgcgcagtt?gggaagggcg?cagccggcgt???6420
gcggtctcgg?cgtgttcggc?gagcgggcgg?cggccgagga?agccggtgcc?gacgaggatc???6480
gacagcagga?agagcgggtt?gccgacggac?gcctcgtggc?aggcctggac?gaactcgtcg???6540
tcgcccgcct?cgccgaagtg?ctcccggacc?agctcgtggg?tggccgtcag?gctgagggag???6600
gcggggcgca?gggtttgggt?gccggcctct?cggatctcgc?gggcgagggt?gtggtggctg???6660
cgggggtccc?cgtcgcgcag?ggcgcagacg?acgacggccc?gcagcccgtg?cagccgcttg???6720
gcgaggtagg?tgagccagcg?cagcgagggc?acgtcggacc?actgcaggtc?gtcgacgagg???6780
atgagcaggc?ggctgtcggc?gctcacgttg?gcgagcagcg?agagcagtcc?gtgcagcacg???6840
gcctcggtgg?cggcgatggc?ctggtcggcg?ccgggcgggg?cggcgtcgtc?ggccaggacg???6900
tggcgggcga?aggaggcgtg?cgcgtccatc?cagcggtccc?gggcgtcctc?gggcgagtcg???6960
ccgagcagcg?tctcgaagag?ctgccgtacg?actccgaagg?cgaagtcctg?ttccatgggg???7020
gccgcgtggg?cccgcagcac?ccggacgtcg?tcccggtcgt?cggccaggca?ggacagccgc???7080
tgcaggaggg?cggagcggcc?gatgccgagg?gggccggtga?ggaggacgag?ggaggacctg???7140
ccttcggtcg?cggcgcccag?ggcggcgtcg?accagggcga?tctcggtggt?gcgctccagc???7200
aacatgcgat?cagctgccct?ccgcttcttg?tacgagtgcg?cgcagttcct?cacgtccgcg???7260
gatgcggagt?ttgcggtaga?cgccgctgag?gcgcagctcc?acggcgcgcg?tggtcacggc???7320
gagttccgtg?gcgatctccc?ggttgcccag?gccctgggcg?gcgagggccg?cggtctcccg???7380
ttcgacggcg?gtcaggccgt?gccagacggc?cgcgtcgtgg?cccggggcct?tcgcggtccg???7440
ccgaccggtc?agcaccgccg?ggcgcgggcc?ggggggcctg?gccaccgcgg?aggggacgtg???7500
cggaccgggg?ggtggggcga?ccggcgggag?caccgtggcg?gccgggccga?gggcgacggc???7560
ggtccggcgc?tcgttctcct?cgcgttcggc?ggcggccagt?tcgatgacgg?cccgggtgta???7620
ggcggtgcgg?gccgatgccg?cgctgagcgt?ggtgacggcg?gcacggaggt?tttcgacccg???7680
gttctcctcg?gtgacgacgg?cgaggctgag?ctgggcgcgg?ccgagcgggg?cggcggcgcc???7740
ccagcggcgg?gcgaggcgga?cttcctcgtg?gaccagccgg?gcggcctcct?cggtgtcgcc???7800
gagggtgtgg?gcggcctcgg?cggcgaggga?gcgccagggc?tggacggccg?ggttggcgca???7860
gccgtgccgc?aggagccagc?gaccgcaggc?gcggaagtgt?tccctggcct?ggtggggctc???7920
gtcgtccgtg?cgggccagca?ccccccgggc?gaagagcagt?tgggcggtgg?tggcgctctc???7980
gtgggcgagc?ggcggcagcg?gccgggcggc?ggtctcgcgg?gcccgttcgg?tgtggccgtt???8040
ctgcagatcg?gtgatcatgc?tcagggcgag?ccagtacggg?aggaagagcg?ggtggaggcg???8100
gtccagcggg?agttccgcct?gggcggcggc?caggtcacgg?gcggcggcgt?cggggcggcc???8160
gtggcggatg?tgcagctcgg?cgcggacggt?gaggatgtgg?gcgaccgaga?tcgccgcgcg???8220
ctcccggtgg?gactcgtcga?gcagggcacc?gaggtggttc?tccgcctcgt?cgccgtcgtc???8280
ggtgagcagg?agggcgcggc?agccgagcag?ccggggtacg?acgaggagcg?ggcggccggt???8340
ggcggcgggg?acgaaggcgg?agcgggcgag?tctgcgtact?tcctcgcggt?ggacgccggc???8400
cacgccgtgt?tcccaggccc?agacccccgc?gacggccggg?ttgtgcaccg?cgtcgggcag???8460
ggcggggacg?gggaggacgt?cgaggtcggc?gtcgtcgtgg?cggaggaagg?aggcgacgcg???8520
gcacaggacg?gtcagttcgt?gccgttcggc?gacggccggg?tcctcgtccg?gcccggcggt???8580
gtccggtcgt?cctgcggcct?cggggccggg?agagcggggg?gcgtcgtggg?cgcggggggt???8640
gccgggaagg?tccggcgcgg?cggatcttct?accgtccggc?ccggtggcgc?cgggcggggt???8700
gcccgcgtag?gggcggtgag?ggacgaggtg?ggtgcgggga?gtcgaggcgg?gctccgcctc???8760
gggcggcacg?gccggggcgc?cggtcgggcc?acgtcgtggt?tcgggggcgg?ccggggccga???8820
gtcgatggct?ccggcgaggg?cgtggcgggc?cgcgcgggtg?tctccgccga?ggaggcacag???8880
gtcggtggcg?cgggcccgca?gtccggcgcc?ggggccgggc?cgggtggccc?ggatgagccc???8940
gcccagccgg?cgttcggcgg?ccgtgggggc?ggtgaccatc?tccacggagg?ccagctggaa???9000
ctcgatccgg?gcgcggtcct?cggcggccag?tggttcgtcc?agggcgcgcg?ccaggtaggc???9060
gacggccagg?tcgcggcggc?cgccgcgcag?cgcggaggtg?aagccccgcc?gcagggtgtc???9120
gacggcccag?gggtcgccga?cggggcgggc?cagcagcagc?aggtcggcta?tgccctggtc???9180
gtcggcggcg?acgcgctggg?cgagcccggc?ggcgcgtgcg?tacagctcgg?cccggtccgc???9240
tgcgggcatc?tcctccagga?cgcgggcgcg?tacgacggcg?tcctggaccc?gggggtggcc???9300
gtcgcgcagg?gtggtcaggc?cgctggccgc?cagggcggcg?cgcaggcggg?actcggagac???9360
ggagtgcggt?ccggcgagcg?tgcagacgag?ggggaagtcg?aggaggtcgc?cgcagacggc???9420
gagggcgcgc?agggcgtcga?cggcggccgg?gtcgcgcagg?tcgctgaggg?cgcgggtggc???9480
gtggtcgccg?acgacctccg?cggtcagggc?gcgcaggggg?tcgatccggt?cggcccgggg???9540
gctgtacccc?gcgcgggcga?aacggtccag?cacgtcgtgg?acgacggccg?ggatgccccg???9600
ggtcgcctcg?gcgagggcct?cggtgaaggc?ggggtccccc?ggggcgccga?aggcccgcag???9660
gacggcggtg?gcggtgccgc?cggaggtgag?gggcggcagc?gccagctcga?tggtggtggc???9720
cagtccggtc?aggggggtgc?cgacgctcca?ctcgggccgg?gtcagggcgg?tgccggtggt???9780
gctggtgagc?agggcgaccg?gggcgcgggg?cagccgccgg?gcgagggctt?ccagccagcg???9840
cagggaggcc?gggtcgagcc?actgggtgtc?gcgtaccacg?agcagggtgg?gccggtcgcg???9900
gacggcgttg?agcaggccgt?tgaggcccgg?cagcccgccg?ggctgctcgt?cggtgaggaa???9960
gaggcgcggg?gcgagtgcgc?ggttctcctc?cgcgaggagc?tgggccacca?cgccgtaccg??10020
cacctcgtgt?tcggcggggg?tggcgtgggc?gctgaggacg?cgcagtccgg?cgtcggtggc??10080
gtacgcggcc?gcccagcgca?gcagatcgtt?ctggccgagc?cccggttctc?cggtcaccgt??10140
caccaccgcg?ggacggccgg?atccgagctc?gccgatgacg?gcggagaggg?cggccagttc??10200
gcggtcgcgc?tccaggagcg?ggagctcgat?gggcggcatg?tgaagatcat?acatttgcgc??10260
agtgcagcag?gtgggcgtct?gtaacccact?gttcttccta?tggatttctc?cgcttcgcat??10320
gtcccggccg?cctctccgca?gccggccggg?cggtggcgcc?ggcctcgcgc?agggcctcgg??10380
tcagatcgcc?ccggcgggcg?actcccagtt?tccggtagac?gctggtgagg?tggagttcca??10440
cggtccgcac?ggtgacgaag?agggattccg?ccacttcgcg?gttgccggcg?cccgaggcga??10500
ccagcccggc?cacggtgcgc?tcggtgccgg?tgagcatgtc?cagcggtgag?gcggtgacct??10560
cgcgcatccg?tccgccggcc?gcgatcagct?cgtcgcgggc?gcgccgggcg?agggcgacgc??10620
acccgcaccg?ccgggccagc?ccgacggcct?cccgtagatg?ctcccggccc?tcccgcacgg??10680
ccccgtcctc?caccagggcg?cgtcccagca?gcaacaggcc?gcgggcgtgc?ccgctccgcg??10740
cgggcgagtc?cgccagcagg?gcgaccgcct?cccgcagcgc?cccggtgcgc?gccgtgccgc??10800
gcgccgccgc?gccccgggcg?agcgcggcgt?accccagggc?ccggcgggtg?ccccagcgtt??10860
cggcgagccg?ggtgccgtgc?gcggcggccc?gccccgcctc?ctcgccgcgt?ccggcctcgc??10920
ccagcagaca?ggccgtctcc?agccaccacg?gcgcgaggac?cgggttggtg?agtccggcct??10980
ccgccatcga?ggcgccgcag?gacccgaaga?cctgcagggc?tccgtccagg?tcgccgtcgg??11040
cggcaagcgc?ccggccacgc?gccatcaggt?accagtggta?ctcccagacg?aaccggtcca??11100
ggtgggggcg?tttgatggcg?tccagcgcct?ccagcgcgcg?ccccggatca?ccccgctcgg??11160
tgaggacgga?ggcgtacgcc?gtgtgcggca?tcgtggcggt?gtcgccccag?cgttcctggc??11220
cgaggatctc?cagcgcggtc?tgcgcgtcgg?ccatcgcgtc?cggcaccgcc?ccgttctcca??11280
ggcggaacag?cgaccgggtg?gagagcgcga?gcacgtacgt?ccagaccgcg?gcggtgtcgc??11340
cgctgccgcg?cagcacggtc?tccaggacct?cctcggcggc?ctcgttctcg?tcggccagcg??11400
acagggcgag?cgaggtgggc?agcagtgacc?agacgcccag?cggcaccccg?ggggcgcgca??11460
gcgcgcggcg?ggcccggccc?acggtctcct?ccgctccccc?gccctcggcg?gcggagagca??11520
cactcagcat?ggcgagttgc?tgacgctggg?cgggggtgtc?ccccggctgc?ggggtgaggc??11580
cctcggtccg?gcgcaggatg?tcgggcaggg?tggccttctc?gtcggagccc?acgatcagca??11640
gggccgactc?cgtgagggtg?cgcagttcgc?ggtcggcggg?ttcgggctcg?ggacccagct??11700
cggcgtcgag?ggcgtccagc?gcctcggtga?gggcccgggc?accgtccggc?gactgctgca??11760
cggcgaggca?ggtcaggccc?agctgaaccg?ctgtggcggc?gcgggcgcgg?acgtccgtgg??11820
tcagggagtg?ggcctcgtgc?agcagggtca?ccgagcgggc?cgggtcggtc?tcggccagcg??11880
ccttgccgag?ccgggagagg?acgtcggggt?ccttcggctc?ggcctcgcgg?acgcgctcca??11940
ggtagcgggc?ggcggcctca?caggcgccgc?gctgttcggc?ctgggcggcg?gcgtcccgga??12000
gcacggagac?cgcccagtcg?tcgggggtgc?ccgggaccag?cagcagctgc?gtggcgatct??12060
cctcggggga?ccgtccgacg?tcgctgagga?gccgggcggc?gcgtctgcgc?aggacggcga??12120
cgcccgacgc?gccgacggcg?tcgaggaccg?cggcgcgcac?caggtcgtgg?gagagctcca??12180
ggtggccggg?gtggatcagc?ccggcgtcgc?gcaggatctc?cacggcctcc?tccacgtgga??12240
cgacggagac?cctgccgagg?gcggccaggt?acgtccggtc?ctcgtcgccg?agcacggcca??12300
cggcacgcgc?gacctggcgc?acccagtccg?gctggtgttc?cagcacaccc?cggacggagg??12360
cggcgacgac?cttcccgccg?gcctgggcga?ggcgtgccgt?cccggtgtcg?tcggggccca??12420
gtccggcgga?gcgcaggtcg?cgcaggagcc?ggacgatctc?cagcgggctg?ccgccggtca??12480
cggagaggag?gcggccgacg?aacgacggca?gggggtcctg?ctccgggaag?gagtgggcgg??12540
tcagctccgc?cacctcggcg?gtgtccagcg?ggccgagccc?gagtgaggcc?ggcaggtggt??12600
gggcgaccag?gtcggcgagg?gcgtcgggag?cggtgaggcc?ggtgccggtg?cggtgggcgg??12660
cgacgacgag?cagcggcagg?ccgtccgcgc?ggcgcagcag?gaagtcgagc?cagcgcaggg??12720
accgctcgtc?gcaccagtgg?acgtcgtcga?ggacgagcac?cagggggccg?tccgccatga??12780
ggttggccgc?gagccagtac?aggccctgga?ggacggagaa?ggtgctgccg?gggtcggcgt??12840
ccagctcccc?cgggtcggcg?gcgagggcgg?gcagcgcgcg?ccgggcgccg?ccgacaagga??12900
gcggcgaggt?acggcccttg?cggccggtca?ggccgagtcc?gccgaacagg?gcgcggaccc??12960
cgctgtagcc?cgtggcgacg?tcgacggcgc?ggcaggagcc?gtacagggtg?gtcatgccgg??13020
cgagggggcc?gtcctcggcc?agggcggcgc?gcagcagtgc?ggtcttgccg?attccggcgg??13080
gaccgtccag?gagcaccagg?cggggtcttc?ccgcgcgggc?ggcgtccgcg?tgccgggcga??13140
ggacgtcgag?ctggtgggcc?ctgccgacga?ggggcggggc?cgggggcacg?gcacgggacc??13200
ggtgaggcac?agggctctcc?ctcgcgtcgg?acggggccag?ggacggcggc?ccggcggaac??13260
cggaacggcc?cggggcggcg?ccccgggacc?ggtcacctgc?ccaccggagc?cacatctacg??13320
cacacccggg?tggccggcgc?agcggtccgg?cgccgaatct?aaggatttcc?ccggtgccgg??13380
acgtgagatc?aagtggtggt?gcggtcgggg?ccgcccctgt?ccggcccggc?cggcgggcgg??13440
catccgccac?cgccccgcgc?ccgtccgcgc?gtgaccggcg?ggccgcgacg?actgtcgccg??13500
tcacttcgtg?aaagggctcc?catggactcc?gccgcccggc?cgatcctctt?cgtcagtctc??13560
cccgagagcg?ggctgctcaa?cccgttgctg?gtgctggccg?gggagcttgc?ccggcgcggt??13620
gtgccggacc?tgtggttcgc?caccgacgag?caccggcgcg?aggaggtgga?ggcgctctcc??13680
gacgtctcca?aggtgtcgtt?cgcctcgctg?ggcgaggtgg?tccccgaact?gtcggcggtg??13740
acctgggacg?acgaggtgta?ccgcgaggtc?acccagtcct?cccgcttcaa?ggcccaccgc??13800
gcggtcgtcc?ggcagtccta?ccggcccgcg?ctccaggcgc?gcaagtaccg?cgagctggag??13860
caggtcgtcg?acgaggtccg?gccggcgctg?atggtcgtcg?actgcgtcgc?gggcttcggc??13920
gtcgacctgg?ccctggcccg?gggcatcccg?tacgtgctga?acgtgccgtt?cgtcgccagc??13980
aacgtgctga?cctcgcacaa?cccgttcggc?gcctcgtaca?cccccaagag?cttcccggtg??14040
cccaactcgg?ggctgcccgc?gcggatgtcg?gtgcggcaga?agctggccaa?cacgctgttc??14100
aagtggcgga?cgctcggcat?gttcctgcac?ccggacatgg?cggcactgct?gcgcgaggac??14160
gccgcgatac?gcaaggaact?gggcatcgcc?ccgccgaacg?ccatgacccg?ggtcgacgag??14220
gccgccgccg?tggtgtgctc?ctccgtcgcg?gaactggact?accccttcga?catcccggac??14280
cgggtgagcc?tggtgggcgc?cgtgctgccg?ccgctgcccg?aggcaccgga?cgacgacgag??14340
gtcaccaggt?ggctcgacgc?gcagtcgtcg?gtggtctaca?tgggcttcgg?caccatcacg??14400
cgcctcaccc?gcgaggaggt?cgcggcgctg?gtggaggtgg?cccggcggat?gtccggcacc??14460
caccagttcc?tgtggaagct?gcccaaggag?cagcagcacc?tgctgcccga?ggccgggtcg??14520
ctgccggaca?acctgcgggt?ggagagctgg?gtgccctcgc?agctcgatgt?gctggcccac??14580
ccgaacgtct?ccgtcttctt?ctcgcacggc?ggcggcaacg?cctaccacga?gggcgtctac??14640
ttcggtaagc?cgcaggtcgt?gcggcccctg?tgggtggact?gcttcgacca?ggcggtccgc??14700
ggccgcgact?tcggcatcag?cctgaccctg?gacaagccgc?acaccgtcga?ccccgacgac??14760
gtggtggaca?agctgacccg?ggtcacctcc?gaccccgcct?tccgtaccga?ggccgaacgc??14820
ctgggcgccc?tgcagcgggc?ggccggaggc?cgtgcggccg?ccgccgatct?cgtgaccggc??14880
ctgctcccgg?cggcatgaca?gcggccgcgc?ccgaggccgc?ctgacccatc?gaccgacagc??14940
agcgaggacc?ccatggcctt?cacccatccc?gtctcccggc?ccgctctgga?cggccgggaa??15000
ctggagtacg?tctccgacgc?cgtctccggc?ggctggatct?cctcccaggg?accgtacgtc??15060
cggcgtttcg?aggaagcctt?cgccgagtgg?aacggcgtgg?cgcacggggt?ggcctgctcc??15120
tccggcaccg?ccgccctcac?cctggcgctg?cgcgcgctga?acatcggccc?gggtgacgag??15180
gtgatcgtgc?cggagttcac?gatggtcgcc?tccgcgtggg?cggtgaccta?caccggcgcc??15240
accccggtct?tcgtggactg?cggcgacgac?ctgaacatcg?acgtcacccg?catcgaggag??15300
aagatcactc?cgcgcacccg?ggcggtcatg?ccggtgcacg?tctacggccg?gcgctgcgac??15360
atggacgccg?tgatggacct?cgccctgcag?tacaacctgc?gggtggtcga?ggactcggcg??15420
gaggcgcacg?gggtccgccc?ggtcggcgac?atcgcctgct?tctcgctctt?cgccaacaag??15480
atcatcacgg?ccggcgaggg?aggcgtctgc?ctcaccgacg?atccccggct?cgccgaacag??15540
ctggcccatc?tgcgggcgat?ggccttcacc?cgcgaccaca?gcttcctgca?caagaaactg??15600
gcctacaact?accggatgac?ggccatgcag?ggcgccgtcg?ccctggccca?gaccgagcgg??15660
ctcgacgaga?tcctcgccac?ccgccgggag?atcgaggccc?gctacgacgc?ggggctcaag??15720
gacctccccg?gcatcaccct?gatgcctgcc?cgcgacgtcc?tgtggatgta?cgacctgcgt??15780
gccgagcgcc?gcgaggaact?ccgcgcccac?ctggacgcac?gcggcatcga?gacccggctg??15840
ttcttcaagc?cgatgagccg?ccagcccggc?tacctcgacc?cggtgtggcc?gacgctcaac??15900
gcccaccggt?tcagcgagga?cggcctgtac?ctgcccaccc?acaccgggct?gaccgccgcc??15960
gaccaggagt?acatcaccgg?cgccgtccgg?gacttctacc?gcgcgggctg?accgacggcc??16020
cgtgcagcgg?gccgcgcaga?ccgcccgccg?ccggcccgac?cgggcgcggc?accagccgac??16080
gcaggaagag?aaacgaggag?cggacatgac?gaccagcccc?ggcccgacgg?tggtcgactt??16140
cccacggcgc?acgccccggg?aaccgctgcc?gctgtcccag?tacgccgaac?accggaagca??16200
gaacggcctg?gtccagacgc?acctgccgaa?cggccggccg?atctggctgg?tgacccggca??16260
cgaggacgtg?cgcgcggtcc?tcacccatcc?ccggatcagc?gccaaccccg?acaacgaggg??16320
cttccccaac?gtcggcgaga?cgatgggggt?gcccaagcag?gagcagatcc?ccggctggtt??16380
cgtcggtctg?gactcccccg?agcacgaccg?tttccgcaag?gtgctgatcc?ccgagttcac??16440
cgtgcgccgc?gtccgtgagc?tgcggccggc?gatcgaacgg?accgtggacg?agcggatcga??16500
cgcgatgctg?gccggcggga?acaccgcgga?cctggtgaac?gacttcgcgc?tgcccgtgcc??16560
gtccctggtc?atctccgcgc?tgctgggggt?gccgtcggcg?gaccgggact?tcttcgagtc??16620
ccgcacccgc?acgctggtcg?ccatccgcac?ctcgaccgac?gaggagcgcg?ccgaggccac??16680
ccggcagctc?ctgcggtaca?tcaaccggct?catcgtcatc?aagaagaagt?ggcgcggcga??16740
ggacctcatc?agccgcctgc?tgtcgaccgg?caagctctcg?gacgaggagc?tgtcgggcgt??16800
cctgctgctc?ctgctgatcg?cgggccacga?gaccacggcg?aacaacatcg?ggctcggcgt??16860
cgtcacgctg?ctctcgcacc?gggagtggat?cggcgacgac?cggctcgtgg?aggagctgct??16920
gcgcctgcac?tcggtggccg?acatggtggc?gctgcgcgtc?gccgtggacg?acgtggagat??16980
cgccggccag?accatccgca?agggcgaggg?catcgtgccg?ctgctcgcct?ccgccaacca??17040
cgacaccgag?gcgttcggct?gcccgcacgc?cttcaacccg?gagcgcaccg?agcgccgtca??17100
cgtggcgttc?ggctacggcg?tccaccagtg?cctgggccag?aacctggtcc?gggtcgagat??17160
ggagatcgcc?taccgcaagc?tcttcgagcg?catcccggag?ctgcggctgg?ccgtgcccga??17220
ggaccagctc?gcctacaagt?acgacgggat?cctgttcggg?ctgcacgagc?tgccggtgcg??17280
ctggtagccg?ggcgccgccg?acggaccccc?catccaccga?ggagccaacg?atcatgcgtg??17340
tcaccgtcga?cagcgagcag?tgcgtaggag?cgggccagtg?cgtcctgaac?gcgccggagg??17400
tcttcgacca?ggacgacgac?ggcgtcgtgg?tcctgctccg?cgcggagccc?gacgagcggg??17460
accacgaggc?ggtccgcacg?gcgggcgacc?tgtgcccgtc?ggcctcggtc?gtcctccagg??17520
aggactgaac?cagccggctg?cgcggaccgg?caccggtgcc?ccgtccggcc?cggccctcgc??17580
acccgcggac?ccgtcgccgg?cggaacaccg?accggcgcca?gaaccatcga?agggactccc??17640
ccgtgaccac?cgctgacgac?accgcggccc?gctggctgcg?gcggtaccac?ccggccgagg??17700
ccgacgcggt?acggctggtg?tgcttcccgc?acgccggcgg?ctccgccagc?ttctaccacc??17760
cggtctcggc?gcggttcgcg?ccgggcgccg?aggtcgtctc?gctccagtac?ccgggccggc??17820
aggaccgccg?caaggagccc?tgtgtcccgg?acctcggcac?gctggccgac?ctgatcaccg??17880
agcagctgct?cccgctggac?gagcggccca?ccgtcttctt?cgggcacagc?atgggggccg??17940
cgctcgcctt?cgagacggcg?tggcggctgg?agcagaaggg?cgccggtccc?cgcaccgtca??18000
tcgcctccgg?acggcgcggc?ccctccacca?cccgcgccga?acgggtccac?acgagggacg??18060
acgacgggat?cgtcgcggag?atgaagcggc?tgaacggcac?ggcggccggt?gtcctcggcg??18120
acgaggagat?cctccgcatg?gcgctgcccg?cgctgcgcgg?cgactaccgc?gccatcgaga??18180
cctacacctg?ccctccggac?cgccggctgg?cctgcgggct?gaccgtgctg?acgggcgagg??18240
acgacccgct?gaccaccgtc?gaggaggcgg?agcggtggcg?cgaccacacc?accgggccgt??18300
tccggctgcg?ggtcttcacg?ggcgggcact?tcttcctcac?ccagcacctc?gacgcggtca??18360
acacggagat?cgcccaggcc?ctccaccccg?accgggccgc?cccggccgcc?tgagcgtccg??18420
gcccggccgg?cggcgggacc?gccggccggg?caggcgctgg?agccgtgacc?gacgcaccgc??18480
cgacggcgta?cgcgcgtacg?cggcggacgt?cgtccgcacc?accggagagc?ccgcacaggc??18540
ccggacggcg?atcccgtccg?accgcctccc?ccgtcacttt?ccgctcacgc?gcctgaggga??18600
caaggacaca?tgcgcaccct?tctcgtcgac?aactacgact?cgttcaccta?caacctcttc??18660
cactacctct?cccgggccaa?cggccgggaa?cccgaggtca?tccgcaacga?cgacccggcc??18720
tggcggcccg?gtctgctcga?cgcgttcgac?aacgtggtgc?tctccccggg?gccgggtacc??18780
ccacaccgcc?cggccgactt?cggcctgtgc?gcccggatcg?ccgaggaggg?ccggctgccg??18840
gtgctcggcg?tctgcctggg?ccaccagggc?atggccctcg?cccacggcgc?ccgggtgggc??18900
cgggcccccg?agccccgtca?cggccgcacc?tcggcggtac?ggcacgacgg?caccgggctc??18960
ttcgaggggc?tgccgcagcc?gctggaggtg?gtgcggtacc?actccctcgc?ggtgacggaa??19020
ctgccgccgg?agctggaggc?caccgcctgg?tcggaggacg?gggtcctgat?ggcgctgcgc??19080
caccgcacgc?tgccgctgtg?gggggtgcag?ttccaccccg?agtcgatcgg?cacccaggac??19140
ggccaccggc?tgctggccaa?cttccgcgac?ctcaccgagc?gccacggccg?aacgcgcccg??19200
ggcggccggg?cggggcacgg?cacgctcccg?ccccccgcgc?ccgcccggga?gacgacggcc??19260
accaccggca?cgccacggcg?gctccgggtc?atcgccgagt?cgctgcccac?gcgctgggac??19320
gccgaggtcg?ccttcgactc?gctgttccgc?accggcgacc?accccttctg?gctcgacagc??19380
agccgtcccg?ggggcgagct?gggccagctc?tccgtgatgg?gcgacgcctc?aggtcccctc??19440
gcccggaccg?ccaaggccga?cgtgcacgcc?ggaacggtca?cggtgagagc?cgacggcgcc??19500
agcagcacgg?tcgagagcgc?cttcctgacc?tggctggaga?acgacctggc?ggggctgcgc??19560
accgaggtgc?ccgaacttcc?cttcgcgttc?gcgctcggct?gggtcggctg?cctgggctac??19620
gagttgaagg?ccgagtgcga?cggcgacgcc?gcgcaccgct?cacccgatcc?cgacgccgtg??19680
ctggtcttcg?ccgaccgggc?cctggtgctg?gaccaccgca?cccgcaccac?ctacctgctg??19740
gcgctggtgg?aggacgacgc?cgaggccgag?gcacgcgcct?ggctcgcggc?ggcctccgcc??19800
accctggagg?ccatcgccgg?gcgggagccc?gagccgtgcc?ccgaggcgcc?cgtgtgcacg??19860
acgggtccgg?tggagctgcg?ccacgaccgg?gacggctacc?tgaagctgat?cgacgtctgc??19920
cagcaggaga?tagccgccgg?ggagacctac?gaggtctgcc?tgaccaacat?ggccgaggcg??19980
gacaccgacc?tcaccccgtg?ggcggcctac?cgcgcgctgc?gccgggtgag?ccccgccccg??20040
ttcgccgcgt?tcctggactt?cggccccatg?gccgtgctca?gcagctctcc?ggagcggttc??20100
ctgcgcatcg?accggcacgg?gcggatggag?tccaagccga?tcaagggcac?gcggccacgc??20160
ggcgccaccc?cgcaggagga?cgccgcgctc?gtacgcgccc?tggccacctg?cgagaaggac??20220
cgcgccgaga?acctgatgat?cgtcgacctg?gtccgccacg?acctggggcg?gtgcgccgag??20280
gtcggctcgg?tcgtcgccga?cccggtgttc?caggtcgaga?cgtacgcgac?cgtgcaccag??20340
ctggtcagta?ccgtcacggc?gcggctgcgc?gaggacagca?gcccggtggc?ggcggtccgg??20400
gcggccttcc?ccggcggatc?gatgaccggg?gcgccgaaga?tccgcaccat?gcagatcatc??20460
gaccggctgg?aaggcgggcc?gcgcggtgtc?tactcgggcg?ccatcggcta?cttctccctc??20520
accggcgcgg?tggacctgtc?catcgtgatc?cgcacggtgg?tgctcagcgg?cggcaggctg??20580
cgctacggcg?tcggcggcgc?cgtcatcgcg?ctctccgacc?cggccgacga?gttcgaggag??20640
acggcggtca?aggccgcccc?gctgctgcgt?ctcctcgaca?ccgccttccc?gggccgtgag??20700
gctcccggca?aggacctcga?cggggaaccc?gacgacggca?cggacgcggg?tgctccgaag??20760
gacctcgtcc?tgcccgggtg?acctcacggg?tgccccggcg?gtccggcggg?ccgccggggc??20820
cccgcgcggc?cggcaccggc?cgcatctcta?gggaaaacac?gggccccgtg?gcaagagcct??20880
ggaaccgttc?ccccctctga?cggcgacgct?cgacatcccg?ggagtgatgg?tgcccgtcca??20940
cgcacacgac?tacgtgaccg?atccgccctc?caccaccggc?aggaccctgg?acgggctgac??21000
gctgccacgg?gtgttcgccg?acgccgtaca?ccggggcggc?gacgccgtgg?ccctggtgga??21060
cggggagtac?gccctgacct?ggagcgcctg?gcggacggcg?gtggacgcgc?tggcgcgcgg??21120
cctccaggag?tccggcgtcg?tctccggcga?cgtggtggcc?ctgcacctgc?ccaacagctg??21180
ggagtacctg?acgctccatc?tggccgccgc?ctcggtcggg?gcggtcacga?tgccggtgca??21240
ccagggcaac?gctccctcgg?acgtccgggc?cctgctggaa?cgggtccggc?ccgcagccgt??21300
cgtcctgccg?gcgcggaccc?aggagggtgg?gggcccgctc?accggcacgg?cgctgcgcga??21360
ggtcctgccc?gagctgcgcg?ccgtgctcgt?cacgggcgac?gcggcgggcg?agggcaccga??21420
gacggtgacc?gagatgctgg?agcggtggtc?cggagaggac?ccgctgcccg?tcgaggtgcg??21480
cccggactcg?ccgttcctgc?tgctgccgtc?ctcgggcacc?acctcggcgc?ggcccaagat??21540
ctgcctccac?tcgcacgagg?ggctgctcac?caactcccgg?gccgccaccg?aggacaccgc??21600
ggacgcctac?gccggcaccc?tgatcaccgc?gtgccccctg?acccactgct?tcggcctcca??21660
gtcggcgtac?tcggcgctct?tccgcgccgg?ccgccaggtg?ctgctgtccg?ggtgggacgt??21720
cggccggttc?ctggagctgg?cccgccggga?gcggcccagc?gtggtggtgg?cggtccccgc??21780
ccaactgcac?gacctggtca?cccgggtgcg?cgaggacgcg?gacggccccg?gcttccggcc??21840
cggccggatc?ctcaccgccg?gagcggccct?gcccccggcg?ctcgtccgcg?acgtgcggga??21900
ggcgctggac?accacgctgg?tggtggtgtg?gggcatgtcg?gaggccggca?acggcaccag??21960
cagcctctcc?gccgacgcgc?cggaggtggt?ctcccgcagc?gtcggccggc?ccacccgcga??22020
cgccgagatg?cgcgtcgtgg?acgaggacgg?cgccccgtgc?ccgcccgggc?agcccggcga??22080
gctgtactac?cgcagtccca?gcatgttccg?tggctacttc?ggcgagccgg?agctgacccg??22140
gtcggtggtg?tcggaggacg?gctggctgcg?caccggcgac?ctcgcctcga?tcggcgagga??22200
cggcctggtc?accttccacg?gccggtcggc?cgaactgatc?aacgtcggcg?gccgcaagtt??22260
caacgcggtg?gagatccagg?cgctcctcgc?ggacctgccg?gacatcggcc?cgctcgccgt??22320
ggtcgccgcg?ccggacccgc?gtctgggcga?gtacccggtc?ctggtggtca?ccgaacggcc??22380
ggccgccgca?ccggcggacg?gcacggcacc?gcgcccgcgc?ggcacggtcg?ggctcgacga??22440
ggtgacggct?catctccggg?gcctgggcac?cgccgagtac?aagattccgc?tggagctggt??22500
ggcccttccc?gagctgcccc?gcactcccgc?ggggaagatc?aaccggcggg?cgctggagca??22560
gtacctcgcc?gacgccgccg?agcggaccgc?cgttactccc?gccgaggcgc?cgcgccccgg??22620
tctccggacg?gcgctggagc?tggtggtgac?cgccgtcgcc?gaggtgctgg?ccgccgtgcc??22680
cggcgaggac?ggcgcgcggc?ccgccgccgc?cggtccgatc?gggccggaca?ccaccttccg??22740
cgcccacggt?ctggactcgg?tcgcctccgt?acggctgcgc?aacgcgctcg?ccgaggccac??22800
ggggctgacg?ctgcccgccg?gactcgcctt?cgacttcccc?accccggccg?ccctggcccg??22860
ggaactggcc?gggctctcct?ccccggccgc?agaggagagc?ccgggtgcgt?ccgcccacga??22920
ggacgagccc?gtcgcgatcg?tctccatggc?ctgccgcctg?cccggcggcg?ccacctcccc??22980
cgaggcgctg?tgggagctgc?tgcgcgacgg?cgtcgacgcc?gtgtccggct?tccccgagga??23040
ccggggctgg?gacctggacg?ccctcttcgg?cgacgacccc?gacgcaccgg?gcacctcggt??23100
ggcgcgcgag?ggcgggttcc?tgcgcgacgc?ggcccacttc?gacgccggct?tcttcgggat??23160
gtccgcgcgg?gaggccctcg?ccaccgaccc?gcagcagcgg?ctgctgctgg?agacggcctg??23220
ggaggccgtg?gagcgcgccg?gcatcgcccc?gcgaaccctg?cggggcagcc?gtaccggtgt??23280
gttcaccggc?gcgatgtacc?acgactacgc?ggccggcgcg?tccgacccgg?ccggggagct??23340
ggagagcctg?ctgccggtgg?gcaccgcggg?cggcgcgctc?tccgggcgga?tcgcctacac??23400
cctcgggctg?agcggtccgg?cgctcaccgt?ggacaccgcc?tgctcctcct?cgctggtcgc??23460
cctgcacctc?gcctgccgct?ccctgcgctc?cggcgagtcg?gacctggcgc?tggccggcgg??23520
cgtcgccgtg?atggccaccc?cggccgcgtt?cgtgggcttc?tcccggctgc?ggggcctttc??23580
ccccgacggc?cgctgcaagt?ccttcggcga?gggagccgac?ggagccgcct?ggtcggaggg??23640
ggccggcctg?ctcatgctgg?agcggctctc?cgacgcccgc?cgcaacggcc?accctgtcct??23700
cgcggtgatc?cgcggctccg?ccgtcaacca?ggacggcgcc?tccaacggac?tgaccgcccc??23760
ccacgggccg?gcccagcgcc?gggtcgtccg?gcaggccctg?gccgacgccg?gtgtccgcgc??23820
cgccgaggtg?gacgtggtcg?aggcgcacgg?aaccggtacc?gccctcggcg?accccatcga??23880
ggccgaggcg?ctgctcgaca?cctacggacg?ggaccggccg?gagggccgtc?cgctgtggct??23940
gggttcggtg?aagtccaacc?tgggacacac?gcaggccgcc?gccggcgccg?ccgccgtgat??24000
caagatggtg?ctggccctgc?ggcacgacct?gctcccggcc?accctgcacg?ccgacacccc??24060
cacctcccgg?gtggactggt?cccccggcac?cgtgcagctg?ctgacgcggg?cccgcgactg??24120
gccccgcgag?gagggcaggc?cgcgccgcgc?gggcgtctcg?tccttcggca?tcagcggcac??24180
caacgcccac?ctcgtcctgg?aggaggcacc?cgtgcccgcc?gccggcacgg?agcggagcgc??24240
ggacgcggga?gccgccggcc?tccgtgccgc?cgtgccgtgg?ctggtgtcgg?ccaaggacgc??24300
ggacgcgctg?cgcggccagg?cccggcgcct?ggccgcacac?gccgccgccc?acccggaggt??24360
gtccgcacgc?gacctcgcct?actccctgct?caccacccgg?gcgctgcacc?cccgcaccgc??24420
cctgctgacc?ggcggcgacc?gggacgcgct?ggtcgcgtcc?gccgacgcct?tcgcccgtgg??24480
cgaggcaccc?gggagcatcg?tccgtggccc?gctcggtccc?gcccccggga?ccgccttcgt??24540
cctcaccggg?cagggcagcc?agcggctcgg?catggggcgc?gggctcgccg?ccgccttccc??24600
ggtcttcgac?gacgctctgc?gcgaggtgtg?cgcgctcctc?gacccgctgc?tggaacggcc??24660
gctgaccgag?gtcatgtggg?ccgcgccgga?cagtgacgag?gcggggctcc?tcggcggcac??24720
gggctacgcc?cagcccgcgc?tcttcgcgtt?cgaggtcgcc?ctgtaccggc?ttctggagtc??24780
gtgggggatc?gtccccgacc?ggctggtggg?gcactcggtc?ggcgagatcg?ccgccgccca??24840
cgtggccggg?gtgctctccc?tgccggacgc?ctgcgccctg?gtcgccgcgc?gggggcggct??24900
gatgcaggcg?ctgccgccgg?gcggcgccat?ggcggcggtg?cgctgctccg?aggcggagat??24960
tctgccgctc?ctggccggac?gcaccgccgg?ggccaccgtc?gccgccgtca?acggcccgcg??25020
gtccgtggtg?ctgtcgggca?ccgaggaggc?cgtggccgag?gtcgtcacgg?aggtctccgc??25080
cgccgggcac?aagacgcgtc?ggctcatggt?cagccacgcc?ttccactcgc?cgctgatgga??25140
gccgatgctc?gcggagttcc?gggcgacggt?cgccgggctg?tcgttcgccg?cgccccaggt??25200
tccgctggtc?tccggcgtca?ccggacggcc?gctcaccgcc?gaggaggccc?gcgacccgga??25260
ccactgggta?cgccatgcca?gggacaccgt?ccgcttcgcc?gacgcgatca?gccatcttgc??25320
cggagaacac?accgagatct?acgtcgagtt?gggcccggag?gccgcactca?ccccgatggt??25380
cgaggagtgc?ctgggcgagc?cggagagcgg?cgacggtccc?gccgtggagc?cggtggtacg??25440
gggcgacgtg?gacgaggagc?gggcggcact?ggccgccgcc?gtacggctgc?acgcgctcgg??25500
cctggacgtg?cagtggcggg?cggtgctgcc?ggaggcccgc?gcggtgccgc?tgccgaccta??25560
cgccttccag?cacgaggcct?actggctggc?cacgtccggt?tccgtggtcg?cggggctgtc??25620
gctgccgggc?ggccgggcgg?ccgacaccgt?tccggacctg?gccgggcggc?tggcggggct??25680
ctccggcggt?gaggcggagg?cgctcgtcac?cgaactggtg?cggaccgagc?tggcggcggt??25740
gaccggtggt?gagatctccg?ccgccggagc?cggcacggcc?ttcaccgagc?tgggcgtcac??25800
ctccgtcacg?gcggtggagc?tgcgcaaccg?gctgaccgcc?gtcaccggcg?tgcggcttcc??25860
cccgaccctg?atcttcgacc?accccacccc?cacggccgtg?gcccgcctca?tcggcgagac??25920
ggtccggggg?agttcggtcc?cgggccgccg?ggacgccgtg?tccctggtgg?acgagttgga??25980
ggcgctgctc?gtctcgggcg?ccgaggtcga?ctcggacacg?gcggcgcggc?tgcggtccct??26040
ggccggccgg?tgggctccgt?cggccaccgg?aacggcggcc?gacgcgaacg?gtccgctgga??26100
tctggacgac?gcctccgacg?aggagctgtt?ccgcctcatg?gacggcggcg?ccccgtgact??26160
ctctccgccc?ggcggctcct?cggcggcgtc?cgccccgggc?gagccgtcgg?gcacccctga??26220
ccgaccgcgt?tccgggcggc?cccgttgctc?cggcgccccg?gccggaacgc?ggccccgcca??26280
ggcggtccgc?cggtcgccca?ccttcacaga?cccacgagcg?gaagtacctc?tcatgaacgg??26340
gctccacctg?ccccccgccc?ccttgcccgc?cccgggcgtg?agcgccgccg?gttccggcga??26400
tctgatgatc?gaggcggagg?gcgtcagcaa?ggcatacggc?acggtccacg?ccctggactc??26460
ggtcagcctc?gccgtccccc?ggggcaccgt?gctgggactc?ctcggccaca?acggcgccgg??26520
gaaaaccacc?ctggtcgaca?tcctcaccac?ggcgctgccg?cccacctcgg?ggcgggcgag??26580
ggtcgccggg?tacgacgtgg?ccgacaagcc?ggtcgagatc?cgccggcgca?tcgggctcac??26640
cgggcagttc?gcctcggtgg?acgcgcagct?cagcgggtac?gacaacctcg?tcctgatcgc??26700
ccgtctgctg?ggcgccgggc?gccgggcggc?ccgcgtgcgc?gcgagggagc?tgctggagct??26760
gttccggctg?acggaggtcg?cggaccggcg?tgcgagcagc?tactcgggcg?ggctgcggcg??26820
gcgcctggac?ctggccgtgt?cgctggtcgg?cgcgccggag?gtgctcttcc?tcgacgagcc??26880
caccaccggc?ctggacccct?ccagccgcat?caacctgtgg?gagatcgtcg?aggggctggt??26940
cgagcagggc?accacggtgc?tgctgaccac?gcagtacctg?gaggaggccg?accggctggc??27000
ggaccggatc?gcggtgctct?ccgcgggccg?ggtcgtcgcg?gcgggcacgg?cgcccgagct??27060
gaaggccacc?gtggggcgcc?gcacggtgac?gctcaccctg?gagaccggcg?aggacgtgag??27120
cgcggcgcgc?acggcgctgc?gcggggcggg?cttcgccccg?gtcgacggcg?aggcccgcac??27180
cgtggtcgtc?ccgatcgacg?ccacacggga?gatcgccgac?atcatcagga?gcctggacca??27240
ggccggcgtc?gaggcgagcg?agctgaactt?cggcgaaccc?acgctcgacg?acgtgtacct??27300
gaccctcgcc?gagcaggccg?ccggccggac?ccgggcatga?ccgcgcggaa?ccccgtcccc??27360
cgcgggcccc?gcctcccgcg?ccccgacacc?ccggcgggcg?ctgccgccgg?ccgacgacgc??27420
ctttcacgga?ggaccccttg?accactcagc?tcgccccgcc?gctgcctccg?gccgtgccac??27480
ggcccgcggc?ggtgcctgcc?ttcggcggga?gttcactgtt?cacccagatc?cgggtgctca??27540
ccgggcggtc?cctgcgggcc?atggtgaccg?acccgggcat?cgtgctcttc?ggcctgatcc??27600
agccggtggt?catcctcttc?gtgctgaccc?aggtcttcag?caagatgggt?atgccgcccc??27660
acttcccgga?cggcgtcagc?tacctcgact?acgtcctgcc?cgccgtcctg?gtggacaacg??27720
ccgcccagtc?ggcgatgcag?tcgggcgtgg?gcctggtgga?ggaccagaag?aacggcatcg??27780
tggcccggct?gcgctccctg?cccgtccacc?cgggcgcgct?gctggccgcc?cgcagcctgg??27840
tcggcctggt?gcgcagcgcc?gtgcaggtcg?cggtcatcat?ggcgctggcg?atgaccgtcc??27900
tcggctactc?ccccaacggc?ggtgccgccg?aactggccct?ctccgcgggg?ctgacgctct??27960
tcatcagctt?ctcgctgggc?tgggcgttca?tcgcggccgg?cgcctggctg?cggcgggccg??28020
agccgctgca?gaacctcgcc?ctgatcgtga?tcttcccgct?gatgttcgcc?tccagcgcct??28080
acgtcccggt?cgcggacctg?ccctcctggc?tgggcgcggt?cgcgagcgtc?aaccccctga??28140
cgtacgcgat?cgacgcgacc?cgggcactgg?cgctggacgt?gcccggcctg?gaccacgcga??28200
tcccggcggt?ggtgatctgc?gccgtgatcg?cggtggtcgg?catgatcgcc?gccgtacgcg??28260
gcttccgccg?gcctctctga?ctccccgcac?gaactccccc?cgtgcgtgcg?gggacggggc??28320
ccgtggacgc?ctctcgcgtc?cacgggcccc?gttccttgcc?cggaggaggc?ggagacagcc??28380
cctggcagga?ggaaacaggc?gacttcggac?cgtccctggc?tcccggacgg?cgcccgtccg??28440
gaccacagcg?cgggcacccg?aacgggcagc?ggacgacggt?cggtccggac?cagggccgtg??28500
gaacaccgga?gcatacggag?gtgcgcaccg?gtatgtcggc?cccgagtagc?gggcaaaaac??28560
gggcacagct?ccgcacggaa?acggaccgag?agactcccat?atctgtctca?cttctgtcag??28620
gagcgctcgt?ccgcagcccc?tgagacggtc?tcggcacccg?gctcaacggc?gtccggaacc??28680
cactgcggcg?accccgaaac?cgggcggtgg?tgatccccac?cgcgaggctg?gagccgctcg??28740
gtcactccct?gcccgcaacg?ggcacggctc?acgtgccgag?gggcgcacgg?aacgcacacg??28800
gcccacgccc?gaaactctct?gaccagcggg?gcaagctccg?catccccaca?gcaaagcagt??28860
ccgcgtcggg?ccgggaacgg?gcagaatcgg?gcctcttcgc?ttccggacgg?cgggcaggag??28920
aacggccctg?gggccggcac?cgtggtgccg?gccccagggc?cgttcgttcg?cggcctgtgc??28980
ggtcaggaga?gtccgagttc?gttgtcgagc?atgtcgaaca?tgtcctcgtc?ggaggcggag??29040
gcgaagtcga?aggactcctc?cgccttctcc?ccgcccttga?gggcctcggc?ccgcatctcc??29100
tgccacttgc?cgcggagaac?ctccagccgg?cccgccacct?ggtcgaagag?ctcggcgccg??29160
acctcggcgc?ccgcgaaagc?cctctccagc?ttgtccagtt?ccgccaggac?caccgccgac??29220
ccgtcggccg?gtgccggggc?cacccgcgtg?tacaggtggg?cgacgagttc?gccgggcgtc??29280
gggtagtcga?acagcagcgt?ggccgggagc?cgcaccccgg?tgagcgcgcc?gagccggttc??29340
cgcagctcga?ccgaggtcag?cgaatcgaag?cccaggtcct?ggaaggcacg?ggcgggttcg??29400
atgtcggcct?ggcccgcgtg?gcccagtacg?gtcgcgatct?ggccgcgtac?caggtccagc??29460
aggacctcct?cgccctcggt?ccgggtgagg?ccggtgaggc?gccgggtgag?gtcggcggcg??29520
gccgccgctc?ccccgtcgga?ggcggcacgg?cgggcctggg?tccggatcag?tgaccggaac??29580
agcggcggca?cctcgccgag?ggagcgcagg?gcccccaggt?cgagccggac?cgggaggacg??29640
gccggggcct?gctcggcggc?gccggtgacc?gcgtcgaaca?gggccaggcc?ctgctcgggg??29700
tcgatcgggg?gcatgcccgc?ccgcgccatc?cgggcggtgt?ccgcctcggt?cagctcaccg??29760
gtcatgccgc?tcccccgggt?ccacgggccc?caggccatcg?acaccgcggg?cagtccacgg??29820
tcccggcggt?ggcgggccag?tgcgtcgagg?aaggcgttgc?ccgccgcgta?gttggcctgt??29880
cccgcgctgc?cgagcgtgcc?ggcgacggag?gagaagagca?cgaaggcgtc?gagcgtaagc??29940
ccctcggtcg?cctcgtggag?gtgccaggcg?gcgtccgcct?tgggccgcag?cacggcggcg??30000
aggcgttccg?gggtgaggga?gtcgagaacc?ccgtcgtcca?ggacaccggc?cgcgtggatc??30060
accgcccgca?gcggacggtc?ggcggggatc?tccgccagca?gcgcgtcgac?ggccgtacgg??30120
tcgccgacgt?cgcaggcggc?gacggtgacg?tgggcgccgg?actcctccag?cgcggcggcc??30180
agttcaccgg?caccctcggc?ggccggacca?cgacggctga?ccaggagcag?gctccggacc??30240
ccgtgctcgg?cgaccaggtg?ccgggcgacg?gtggcgccga?ggccgccggt?gccgcccgtg??30300
atcagcacgg?tgccctccgg?gtcccagccg?gccgcgtcgc?tctcggcggg?cgtcaccgcg??30360
cgcaccaggc?gaggtgccag?caggcggtcc?tcgcgcaggg?cgagctgcgg?ttcgcccgag??30420
gccagcgccg?cccgcagggc?ggacatcccg?agcggagagg?tggccgaggg?ctccaggtcg??30480
aggaggatga?accggcccgg?gttctccgcc?tgcgcggcgc?gcaccagccc?ccagaccgcc??30540
gcggcggccg?ggtcggcgcc?gtcggaggca?ccccgggtga?cgacgaccag?gcgggaggcg??30600
gcgaaccgct?cctgggccga?ccagtcgcgg?agggtctcca?ggacccgggc?ggtggcggcg??30660
tgggcggcgg?cggccacgtc?cccggtgccg?gacccggcct?ccggggcggt?ggcgaccggc??30720
agcagcacca?cggacggcac?gtcctccccg?ggcccggtgc?cggtgacgag?gtccgccaga??30780
ccggtcacgc?cctccgtccc?ggcttcggcg?aggaggtcgc?cgccgccgag?gagcgcggtg??30840
tccgggccga?gcacggcgac?cgggccgggc?gtctcggcgt?cccgcgtggc?ggggtccccg??30900
gcagccgccc?agtccagctg?gaacagggag?tcgcggcccg?cgccgcccgc?gccgccgaac??30960
tgcccggcgg?agagcgggcg?ggtcaccagg?gacccgaccg?aggcgaccgg?ggtgccggcg??31020
gtgtcggtga?cggcgatcgc?gagggtgccg?tcgtcggtac?gggagagccg?cagccgtacc??31080
gaggaggcgc?ccacggcgtg?cacggagacc?ccgttccagg?agaacgggac?gccgccggtg??31140
ccttcggact?ccccgccgtc?gccggccagg?gcggtggcgt?ggagtccggc?gtcgaagagc??31200
gccgggtgca?gggtgaacgc?gtcgccgtcg?gtgccgtcgg?gcagcgacgc?ctcggcgaag??31260
acctcgccgt?cgcggctcca?ggcggcacgc?agcccctgga?agacgggccc?gtaggcgaac??31320
ccggcgtcct?cgaaacgctc?gtacagcccg?gtggtgtcga?gcggctcggc?cttctccggc??31380
ggccacacgg?tggcgtcgaa?gtcggtggcg?ggggcctgtg?ccggtccggc?ggccagggtg??31440
ccctcggcgt?gcgaggtcca?cggggcgccg?gagtcgtcgg?cgggccggga?gtggatggtg??31500
atcccgcgcc?ggccctcctc?gtcgggggcg?ccgacgccga?cctgcacctg?gacggtgccc??31560
tgctcgggca?ggaccagcgg?ggccgccagg?gtcagttcct?ccaccacgtc?gcagccgagc??31620
acgccgcccg?cgtggactgc?gagttccagc?agggcggtgc?cgggcaccag?gacggcgccc??31680
atgacacggt?ggtcggagat?ccagccgtgg?gtgccctggg?aaagacgtcc?ggtgaacagg??31740
tggccgtccg?tgccggccag?ttcgaccgcg?ccgccgagca?gcgggtggcc?ggcgggcgcg??31800
agcccggcgg?cctccgcccc?ggcgcccagg?ggcatcatcc?cggcgggcca?gaaccggcgc??31860
cgctggaagg?cgtacgtggg?cagctccacc?cggcgggcgc?cgcggccggc?gaagaacgcg??31920
ggccagtcga?cgcggacacc?gtggccgtgc?agccgggcga?ccgcctcgac?cagggcctgc??31980
tcgccgggga?cggtgcggcg?ctgggcggcg?accgtcacgg?cggactcggg?cagggactcg??32040
cgggccatgg?cgcaggcgac?accgtcgggg?cccagttcca?ggtagcgggt?ggcaccggcc??32100
tcgtgcaggg?cccggacgcc?gtcggcgaag?cggacggcct?cccggacgtg?gcgcacccag??32160
tactcggcgg?agcacagttc?ctccgcgcgg?gccgtggtcc?cggtgaggtt?ggagacgacg??32220
ggtatcacgg?gtgcctgcgg?ggagaggccg?gcgacgacgg?cccggaactc?ggcgagcatc??32280
ggttccatca?gcggcgagtg?gaaggcgtgc?gagacgcgca?gcgcggtcgt?ccggcgaccg??32340
cgctcccgca?gggcctcggt?caccttctcc?accccttcgg?cggtgcccga?caccacgacg??32400
gacgtgggtc?cgttgacggc?ggcgaccgag?accccgtcgg?tgaggtgcgc?gagcacctcg??32460
tcctcggtgg?cctggacggc?ggccatcgcg?ccgccctccg?gcagtgcctg?catcaggcgg??32520
ccccgcgcgg?cgaccagggc?gcaggcgtcg?gccagcgaga?agaccccggc?gacgtgcgcg??32580
gcggcgatct?cgccgatcga?gtggcccgcc?accaggtcgg?gggtgacgcc?ccacgaggcg??32640
acgagccggt?ggaggcccac?tccgagggcg?aagagcgcgg?cctgcgcgta?ggcggtggcg??32700
ttcagggcgt?cctcgtcgtc?gccccagacc?acctcccgca?gcgggcggtc?caggtgcgcg??32760
tcgagtccgg?cgcagaccgc?gtcgaacgcc?tcggcgaaca?ccgggaagcg?ctcgtagagg??32820
tcgcggccca?tgccgagccg?ctgggagccc?tgccccggga?agaggagggc?gagcagcccc??32880
tcaccggtcg?tcgtggccgg?ttcctcgccc?cgggccacgg?agccgagcgc?ggccagcaga??32940
ccgtcccggc?cggcgcccgt?gacggcgacc?cggtgctcga?acgcggtacg?ggcggtggcc??33000
agagagtagg?cgacgtccag?cgggcgcgcc?tcggttccgc?cggcggccgg?gtggtccccc??33060
gtcaggtggt?ggaggagccg?ctcggcctgg?gcgcgcaggg?cgtcccggtc?gcgggcggac??33120
agcagccacg?ggacgacagg?ggcgacgccg?tcgtcgtccg?cgccggtcgc?gggctcgtcg??33180
gacggcacgg?ccgcgggcgc?ctgctcgacg?atgacgtggg?cgttggtgcc?gctgatcccg??33240
aaggaggaga?tcccggcgcg?gcgcgggcgg?ccggagccgg?tccactgccg?ggcctcggtc??33300
agcagctcca?ccgacccggt?ggtccagtcg?acctggtcgc?tgggggcgtc?gacgttcagc??33360
gtggcgggca?gcagcccgtt?gcgcagcgcc?agcaccatct?tgatgacgcc?ggcgactccc??33420
gccgcggcct?gggcgtgccc?gatgttcgac?ttgaccgagc?cgagcagcag?cggccggtcc??33480
tcggggcggt?cctggccgta?ggtggcgagg?agcgcctggg?cctcgatggg?gtcgcccagg??33540
gtggtgccgg?tgccgtgcgc?ctcgacggcg?tcgacctggt?cggcggcgag?ccgggcgttg??33600
gccagggcct?gccggatgac?gcggcgctgg?gacgggccgt?tgggcgcggt?gaggccgttg??33660
ctcgcgccgt?cctggttgac?ggcggagccg?cggacgacgg?cgagtacctc?gtggccgttg??33720
cgcaccgcgt?cggagagccg?ctcgacgacg?aggaagcccg?cgccctcgga?gaagccggtg??33780
ccgtcggccg?ccgacgcgaa?ggacttgcag?cggccgtcgg?gggcgaggcc?gccctggcgg??33840
ccgaactcgg?cgaacacggc?cggtgtcgac?agcacggtga?caccaccggt?gaccgccagg??33900
gagcactcgc?cctgccggag?cgcctgcacg?gcgaggtgca?gggcgaccag?cgaggaggag??33960
caggccgtgt?cgacggagac?ggcggggccc?tccagtccga?gcttgtaggc?gacgcggccg??34020
gtgaccacgc?tgccgttgcc?gtcgctgccc?gggtagtcgt?ggtacatcac?gccggtgaag??34080
acgccggtcc?ggctgccctt?gagcgaggcc?gggtcgatcc?cggcccgctc?cagggcctcc??34140
caggacatct?ccagtgccag?gcgctgctgc?gggtccatgc?cgagcgcctc?gcgcggcgag??34200
atgccgaaga?aggcggggtc?gaagtcggcc?gccccgtcga?ggaagccgcc?ttcccgggcg??34260
tacaggccgt?ccgggtggtc?gccgtcgggg?tcgcggagga?tcgacaggtc?ccagccgcgg??34320
tcctggggga?aggggacgat?cgcgtcgtcg?ccggaggtga?ccaggcgcca?gaggtcctcg??34380
ggcgagctga?cgccgcccgg?gtagcggcag?gccatgccga?cgatggcgat?gggttcgtgc??34440
tgggccgagg?tgagcctgcg?gttgtcgcgg?cgcagccggg?cggtctcggc?acgggcggca??34500
cggagcgcgt?cggcgcccgg?ttcggtggcc?gtgccggtcc?cggcggtctc?ggccgcgccg??34560
tcgctctcgt?cgtacggtcc?ggaggcgtcg?tcctcgtcgt?cgccgtcgaa?ggcggcgagc??34620
agggcgtccc?ggtcggtgtc?ggacatctcg?tcggagtccg?cggcgagttc?gagcagcgtc??34680
tccgccagcc?ccgcgtcacg?caggcggcgg?gccgggatgg?cggagagggc?gcggcgcacc??34740
ccgtcgtcgt?cgccggtggc?accgcccgcg?ccggaggcgg?ggtgggcggc?ggcgagttcc??34800
tcctcgacga?cctcggtgac?ggcgagggcg?ttggggtggt?cgaagacgag?ggtggcgggc??34860
agcctcagtc?cggtcagcgt?gttgagctgg?ttgcgcagct?cggtcgcggc?cagggagtcg??34920
aagcccagtt?cctggaatgc?ccggtcagcg?ccgatcgcct?ccgccgaacc?gtgccccagc??34980
accgccgcga?cctgcgaccg?gacgagatgc?agcaccgcgc?ggtgccgttc?gggcgcgggc??35040
agttcggcga?gcctgcggga?cggggagtcg?tccgggcccg?gcgcggcagc?cgaacccgag??35100
gccgcggtgg?cgcggcgggc?gggagccagc?gcgcgcagga?gggcggggat?ctcgtcggtg??35160
cgggtgcgca?gcgcggcggt?gtcgacgcgc?agcggcacga?cggtcgcctc?gcttcggtcc??35220
aggccggccg?cgaacagctc?cagccccgcc?tcgtgcgaca?gcaacggcag?cccctgcgac??35280
gccatccgac?gccggtccac?ctccgacaga?tactccccca?gacccgcacc?cacgtcccag??35340
aacccgaacg?ccatggacgt?ggccaccaga?ccctcggccc?gacgccgcga?cgccaacgcg??35400
tccaggaaca?cattggccgc?cgcgtaattg?ccctgccccg?ccgtcagcac?cagaccaccc??35460
gccgacgaca?ccagcacgaa?cgccgccagc?tccacacccg?ccgtcgcctc?gtgcaaccac??35520
cacgccgcat?cagccttcgc?acccagcacc?gcatcgaacc?ggtcgggagt?gagggagccc??35580
aggagcccgt?tgtcaccgac?tccggccgcg?tggaccacgg?ccagcagccc?gcgcccggag??35640
acgagagagc?cgacgaggtc?cacgaccgat?tcgcggtcgg?acaggtcgca?cgcgacgacc??35700
tccaccgccg?caccggcctc?acgcagttcc?ccggccagct?ccgccgcacc?cggggcgtcc??35760
ccgccccgcc?gcgacaccag?caccagatcc?cgcaccccac?gctcagccac?cagataccgg??35820
gccatcaccg?cacccagacc?acccgtacca?cccgtcacca?gcaccgcacc?ctcaccatcc??35880
aacgacggca?cggacagcgg?cagttcggca?gcgggtgcgt?cggcggtcag?ccgcgtcagc??35940
ctcggtacga?ggaccacgcc?gtcccggacg?gcgacctcgg?cctcgcccga?gaggacagcc??36000
gcgaccgcac?agtccaccgc?cgcatcatcc?gcgtccacgg?cgacatcggc?cagggcgaac??36060
cggcccggat?tctccgcgag?cgccgcccgc?accagacccc?acacaggggc?ctgcacgacg??36120
tcgccctcgg?ccggggcgcc?gccggaaccc?acgggcatag?cgccccgggt?caccacgacg??36180
agccgggagg?cggcgaaccg?ctcctcggtc?agccagcgct?gtgccacggt?cagcacaccg??36240
tccagcgcgg?agcgcaccga?gccgggcacg?tcggccccgg?ccggagcgga?ggcgtccagc??36300
acgaccacgg?cgggcacctc?ggtaccggcc?tcctcgaccc?gggaccaggt?ggcccaggcc??36360
gtgtcggtgt?cgtcgagccg?ggtcacgggg?acccactcgg?gggcgtagag?cgcgcccgcg??36420
tcacggggcg?ccgcaccgag?ctggccggcg?gagacggtgc?ggctcaccat?ggagccgacc??36480
gtcaggaccg?gggctccggt?gacgtcggtg?acgcggatgt?ccataccgcc?gtcggcggcg??36540
gtggcgatcc?ggacgcggac?ggcggcggcg?ccgaccgcgt?gcagggcgac?ccggttccac??36600
gcgaacggga?tgacggtccc?gccgctcccg?ccctcggcgt?tgtcgttgct?gtcgttgctg??36660
tcgttgctgt?cgttgaggat?cgcgacgtgc?atggcggcgt?cgagcagcgc?cgggtggagg??36720
ccgaagcggc?ccgcctccga?ggcagcctcc?tccgggagcg?ccacctcggc?gaagagttcc??36780
ccgccccggc?gccaggcggc?gcgcagcccc?tggaagaccg?gcccgtagcc?gtagccacgc??36840
tcgcggaaga?tctggtacgc?gctgtccacg?ggcacgctcg?cggccccggt?cggcggccac??36900
tgctccagtg?cggcctcggc?ccctgccacg?agggcgttgt?cggtgaggaa?gccggtggcg??36960
tgggtggccc?actcctgccc?ggtgccctcg?gggcgtgagt?agacggcgac?cgtgcggcgt??37020
tcggcggtgc?gcggtccgac?gaccacgcgg?acctgggcgc?cgccgtgctc?gggaagtacc??37080
aggggtgtcg?ccagggtcag?ttcgtcgagt?acggcgcagt?cgacggactc?tccggcggcg??37140
agggccagtt?ccacgaggac?ggcgccgggc?agcatgaccc?ggccgaggac?cacgtggtcg??37200
gcaagccacg?gctgcgcctc?caccgacagc?aggcccgtca?gcaccgcgcc?tccggagtcc??37260
ggcagcgaca?ccaccgcgcc?cagcaacgga?tggtcggccg?cgtcgagtcc?ggctccggcc??37320
gcggccgggg?ctccgtcggt?ggcggtcagc?cagtaccgct?ggcgctggaa?ggcgtaggtg??37380
ggcaggtcga?cggggccggc?gccggagccg?gcgaagaagc?cggcccagtc?gacggccgtg??37440
cccgcggtgt?gcagctgcgc?gagcgcggtg?agcagggcgt?cgggctcctc?ccgtcccttg??37500
cgggccgacg?gcaccagcag?gactgcggtg?tcctcgtcgc?cgtcgaggca?ggtgcgggcc??37560
atgccggtga?gtacggcgtc?ggggccgatc?tcgacacagc?ggtccacgcc?cgcggcgcgc??37620
agtgcccgga?cgccgtcgcc?gaagcggacg?gcctcgcgga?cgtgggtgac?ccagtagtca??37680
ggtgtggcca?gttcaccgga?ctccgcgatc?cggcccgaga?cgttcgagac?gaccggcagc??37740
gacggctccg?cgtacgacac?cccggacaga?acctctcgga?agtcagcgag?catcggttcc??37800
atcagcggcg?agtggaaagc?gtgcgacacc?cgcagctggc?tgacccgccg?tccctgctca??37860
cggaacacct?cagccaccgc?ctcaacggct?tccccggcgc?ccgagacgac?caccgacgac??37920
ggaccgttga?ccgcagcgac?cgacacacct?tcgacggact?ccagatgcgg?cagcacctcc??37980
gtctcggacg?cctccacggc?caccatcgcg?ccgccctccg?gcaacgcctg?catcagccgc??38040
ccacgagcag?ccaccagagc?acaggcgtcc?gccagcgaga?acacacccgc?cacatgcgcg??38100
gccgccacct?caccgatcga?atggccggcc?accaggtcag?gcgtgacgcc?ccatgaggcg??38160
agaagccgga?agagggcgac?ttcgtaggcg?aacagggcgg?actgggcgta?cgccgtgccg??38220
tcgaggtccg?gcgcgttctc?gccccaggcc?acctcgcgca?gcgggcggtc?caggtgctcg??38280
tcgagcccgg?cgcagaccgc?gtcgaacgcc?tccgcgaaga?cggggaacgc?ctcgtggagg??38340
ccgcgcccca?tctccaggcg?ctgtgcgccc?tgcccggaga?agaggaaggc?cgtggtaccg??38400
acggagcggg?cggttccggt?gatgaccccg?ggggcgtgct?cgccggccgc?gagggcgcgc??38460
aggccggtca?ggaggtcgtc?ccggccggtg?ccgaggacca?ccgcgcgggc?ctccagcggg??38520
gtgcgggagg?tggccagcgc?gtgggcgacg?tccagcggac?gggtgccggg?ccggtccgcc??38580
aggtggtcca?gaaggcgggt?ggcctgggcg?cgcagggcgt?ccggggtggc?cgccgagacc??38640
gtccacggga?ggacggcggg?ggcgcggccc?tcctcggccg?tgctcggcgc?gtcggctgcg??38700
gcgtcggggc?cctgttccag?gacgacgtgc?gcgttggtgc?cgctgaggcc?gaacgccgag??38760
acgctcgccc?ggcgcgggcg?gccggtgacc?ggccacggcc?ggtcctcggt?gacgagttcg??38820
gcgcggccct?cggtccagtc?gacgtgcggg?gacggccggt?cgacgtgaag?ggtgcgcggc??38880
acggtgccgt?gctccatcgc?catgaccatc?ttgatgacgc?cggcgactcc?cgccgcggcc??38940
tgggcgtgcc?cgatgttgga?cttgaccgag?ccgagcagca?gcggccggtc?ctcggggcgg??39000
tcctggccgt?aggtggcgag?gagcgcctgg?gcctcgatgg?ggtcgcccag?ggtggtgccg??39060
gtgccgtgcg?cctcgaccac?gtcgacttcg?gaggcgggga?ccccggcgcc?gtgcagagcc??39120
tggcggatca?cgcgctgctg?ggaggggccg?ttgggggcgg?tgaagccgtt?ggaggcgccg??39180
tcctggttga?cggccgtgcc?cttgacgacg?gccagcacgc?ggtggccgtt?gcgcacggcg??39240
tcggagagcc?gctccaccag?gaggacgccg?acgccctcgg?accagcccac?gccgtccgcc??39300
gcgcccgcga?acgccttgca?gcggccgtcc?accgacaggc?cacgctggcg?gctgaactcg??39360
acgaacattc?cgggcgtcga?catcacggtg?gcgccgccgg?ccacggccag?cgagcactcg??39420
cccgagcgca?gggcctgtac?cgcgaggtgc?agcgcgacca?gggacgagga?gcaggccgtg??39480
tccacggtga?cggctgggcc?ctcccagccg?aaggtgtacg?acaggcggcc?ggagaccacg??39540
ctgccgccgg?cggtgccgga?gggcgagacg?ttcagcgcgt?agtcgtggta?catgacgccg??39600
gcgaagacgc?cggtgcggct?gccccgcagc?gtcgccgggt?cgatcccggc?gcgttccagc??39660
gcctcccagg?aggtctccag?gagcaggcgc?tgctgcgggt?ccatgtacag?ggcctcgcgg??39720
ggcgagatgc?cgaagaagcc?ggggtcgaac?tgggcggcgt?cgtgcaggaa?gctgccgcgc??39780
ctggtgtagc?tcttgccctc?cttgccgggc?tcggggtcgt?agaggccctc?gatgtcccag??39840
ccccggtcac?cggggaggtc?ggagacggtg?tcgacgccgt?cggtgaccag?gcgccacagc??39900
tcctcggggg?tggtgacgcc?gccggggtag?cggcaggcca?tgccgacgat?ggcgatgggc??39960
tcgtcgtcgg?ccggtgctgc?cgtgcccgta?cggacggggg?tctccgcccg?cgcggactcc??40020
ccggccagtc?gcgccgagag?gtgatcggtg?acggcgaggg?cgttggggtg?gtcgaagacg??40080
agggtggcgg?gcagcctcag?tccggtcagc?gtgttgagct?ggttgcgcag?ttcggtcgcg??40140
gccagcgagt?cgaagcccag?ttcctggaag?gcccggtcag?cgccgatcgc?ctccgccgaa??40200
ccgtgcccca?gcaccgccgc?cacctgcgac?cggacgaggt?ggagcagggt?gcggtgccgc??40260
tccgcctccg?gaagcgaggc?cagccggtgg?gccggcgagc?cctcgacggt?ggccgggggg??40320
accacggccg?cggagcgccg?cacgggagcg?agggacttga?gcagggcggg?gatctcgtcg??40380
gtgcgggtgc?gcagcgcggc?ggtgtcgacg?cgcagcggca?cgaccgtcgc?ctcgccccgg??40440
tccaggccgg?ccgcgaacag?ctccagcccc?gcctcgtgcg?acagcaacgg?cagcccctgc??40500
gacgccatcc?gacgccggtc?cacctccgac?agatactccc?ccagccccgc?acccacgtcc??40560
cagaacccga?acgccatgga?cgtggccacc?agaccctcgg?cccgacgccg?cgacgccaac??40620
gcgtccagga?acacattggc?cgccgcgtaa?ttcccctggc?ccgccgtcag?caccagacca??40680
cccgccgacg?acaccagcac?gaacgcagcc?agctccacac?ccgccgtcgc?ctcgtgcaac??40740
caccacgccg?catcagcctt?cgcacccagc?accgcatcga?accggtcgga?cgacagcgtg??40800
cccaccaggc?cgccgccgcc?gaccccggcc?gcgtgcacga?cggcgcgcag?cccacgcccg??40860
gcgacgaggg?actcgaccag?gccgacgacc?gattcgcggt?cggacaggtc?gcacgcgacg??40920
acctccaccg?ccgcgccggc?ctcacgcagt?tccccggcca?gctccgccgc?gcccggggcg??40980
tccccgcccc?gccgcgacac?cagcaccaga?tcccgcacac?cacgctcagc?caccagatac??41040
cgcgccatca?ccgcacccag?accacccgta?ccacccgtca?ccagcaccgc?accctcacca??41100
tccagcgacg?gcacggacag?gggcagttca?ggctcggcga?gacgactgag?cctcggcacc??41160
agcacaacac?cgtcacggac?ggcgacctcg?gcctcgcccg?agagggcagc?cgcgaccgca??41220
cggtccaccg?ccgcgtcatc?cgcgtccacg?gagacatcgg?ccagggcgaa?ccggcccggg??41280
ttctccgcga?gtgccgcccg?caccagaccc?cacacggggg?cctggacgac?gtcggcggat??41340
gaaccggccg?gggcggcgcc?acgggtgacg?acgaccagac?gcgaggaggt?gaagcgctcg??41400
tcgcggagcc?actgctggat?cgcgggaagg?acctggtcca?ggacggcccg?gacggcggca??41460
gggacgtccg?gaccggcggg?ctcgcgcacc?tccaggacga?ccgcgcccgg?cgccgtggtg??41520
tccgcctcca?gggcttcggc?ccaggagacg?tgggcggggg?ccgtggaggt?gtccacggtg??41580
accggcgtcc?actcgatgcc?gtagagggcg?cccgcgccgg?cggaggcgct?gccgagctgt??41640
tcggcggaga?ccgggcggct?cgccagggag?cccacggtca?ggaccggcgc?gccggtggag??41700
tcggcgaggg?tcagggagac?ggtgtgggcg?tcgacgcggc?tcacgcgtac?gcggacggcg??41760
gaggcgccga?cggcgtggag?agtcacgtcg?ttccaggcga?acgggacgac?cgcctggccc??41820
tcctcctcgt?tcaggatgcc?ggcgtgcatg?gcggcgtcga?gtacggccgg?gtgcaggccg??41880
aaccggcccg?cctcacctgc?cgcgtcctcg?gggagcgcca?cttccgcgaa?catcgcgtcg??41940
tcgcgccgcc?aggcggcgcg?caggccctgg?aagaccggcc?cgtagccgta?tccccggtgg??42000
cggaactcct?cgtaggcgtg?ctcgaccggt?accgggtcgg?cgccgggcgg?gggccactcg??42060
gtcagcgctt?cgccggagcc?tgccggggcg?tcggtgagga?agccgtgcgc?gtgggccgtc??42120
cacggcgcgt?cctccgcgcc?ctcgggacgg?gagtggacgg?ccacggtgcg?gcgtccgtcg??42180
gtcttcggcc?ccgcgacgac?gcggagctgg?aggccggtgt?cctcgggcag?caccagcggc??42240
gcggcgaggg?tcagctcctc?gagagcggtg?gagccggccg?cgtccccggc?cgcgagggcc??42300
agttccacca?ggcccgtacc?gggcagcagg?acccggccga?ggaccacgtg?gtcggcgagc??42360
cacggctgcg?cctccaccga?cagccggccc?gtcagcacca?cgccacccga?gtccggcagt??42420
gacaccaccg?cgcctagcaa?cgggtggtcg?gccgcgtcga?cccccgccga?cctggggtcg??42480
gcggcggcgc?ggaccgtggt?ctccggccag?aagcgccgct?tctggaaggc?gtaggtcggc??42540
aggtccacgg?tgcgggccgc?ggtaccggcg?aagaagccgg?tccacttcac?ctcggcgccc??42600
accgtgtgga?gacgggccag?cgcggcgagc?gccgtcgacg?tctcctcacg?gtccttgcgc??42660
aggagcggga?cgaggacggc?gtcctcaccg?gcgccctcgc?gcgccatgcc?gctgagcacc??42720
ccgtccggac?ccagctccac?gaaccgggtg?acgccctcct?ccgcgagggc?ccggacaccg??42780
tcgtcgaagc?ggacggcctc?gcggacgtgg?gtgacccagt?agtcaggcgt?ggtcagttca??42840
ccgggttccg?cgatccggcc?cgagacgttc?gagacgaccg?gcagcgaagg?ctccgcgtac??42900
gacaggccgg?acagaacctc?tcggaagtca?ccgagcatcg?gctccatcag?cggcgagtgg??42960
aaagcgtgcg?acacccgcag?cctgctgacc?cggcgtccct?gctcacggaa?gacctcggcg??43020
accgcctcga?cggcgtcctc?ggcgcccgag?acgaccacgg?aggaagaccc?gttgacggcg??43080
gcgacggaca?ccccctcgac?ggattccagt?cgcggcagca?cctccgcctc?cgacgcctcc??43140
agggcgacca?tggcgccccc?ctcgggcagc?gcctgcatca?gacggccacg?ggcggcgacg??43200
agcgcggcgg?cgtcggcgag?ggtgaacacc?ccggccacgt?gcgcagcggc?gacctcaccg??43260
atggagtgac?cggccacgaa?ctccggccgc?accccccacg?actcgaccag?ccggaacaac??43320
gccacctcga?cggcgaagag?accggcctgc?gcgtacgccg?tcccgtccag?aaccgacgtg??43380
tcgtcgcccc?agaccacctc?acgcagcggg?cgctccaggt?gctcgtccaa?cccggcgcag??43440
accgcgtcga?acgcctccgc?gaacaccggg?aaacgctcgt?acagcccacg?ccccattccc??43500
agacgctgcg?acccctgtcc?cgagaacagg?aacgcggtac?ggcctccggt?ggccacgcct??43560
tccacgacgc?ccgcgtcggg?cagacccgag?gccagggctt?ccagggccgc?ttcacggtcg??43620
gtgcccagga?ccaccgcccg?gtggtcgaag?gtggcgcggc?cggagaccag?cgagaaggcc??43680
acgtccggcg?cgctcaccgg?ttcggcggcc?acgtgcacgc?gcagccgctc?ggcctgggcg??43740
cgcagcgccg?gggccgaccg?tgcggagagc?acccacggca?cgtcgacggc?gggcgccacc??43800
gtgggcgcgg?gctcctgcgc?ctcctccggc?tgttcgagga?tgacgtgggc?gttggtgccg??43860
ctgatcccga?acgaggacac?accggcccgg?cgcagccgct?cctcccccgg?ccacacccgc??43920
tcaccggtca?gcaactccac?agcaccggcc?gaccagtcga?cgtgcgacga?cggagcatcc??43980
acatgcagcg?tgcgcggtag?cctgccgtga?cgcatcgcca?tcaccatctt?gatcacaccc??44040
gccacaccgg?cggcagcctg?cgtgtgcccg?atgttggact?tgacggaacc?gagcagcaac??44100
ggccgctcct?cgtcccggcc?ctgcccgtac?gtcgccagga?gcgcctgtgc?ctcgatcggg??44160
tcacccaacg?tcgtccccgt?accgtgcgcc?tccacgacat?ccacatcacc?ggcggacaga??44220
ccaccgctcg?ccagagcctg?acggatgacc?cgctgctggg?aaggaccgtt?gggcgccgtc??44280
agaccgttcg?acgcaccgtc?ctggttcacc?gccgaaccac?gcaccaccgc?cagcacacga??44340
tgaccgttgc?gccgggcatc?cgacagacgc?tccagcacca?ccatgcccac?gccctcggac??44400
cagcccgcgc?cgtcggcggc?gtcggagaac?gccttgcagc?ggctgtccgg?ggagagggcg??44450
ccctggcggg?agaactccac?gaaggcggtg?ggggtggcca?tgacggtgac?gccgccggcc??44520
acggccagcg?agcactcacc?ggagcgcagc?gcctgcgccg?cccagtgcat?ggcgacgagc??44580
gacgaggagc?aggcggtgtc?gaccgtgacc?gcgggtcctt?cgaagccgaa?ggtgtaggag??44640
acacggcccg?aggcgatgct?gcccgcgctg?ccgttgccgc?gatagccctc?gtactggtcg??44700
tcggtgagga?tgctgccgta?gtcgttgtac?atgacaccgg?cgaagacacc?ggtctggctg??44760
ccgcgcaggg?agaccgggtc?gataccggac?cgctcgatcg?cttcccacgt?cgtctccagc??44820
aggagacgct?gctgcgcgtc?cgtggagacg?gcctcacgcg?ggctcatccc?gaagaactcc??44880
gggtcgaact?cgggcgcgtc?gtgcaggaag?ccaccggacc?gggtgtacgt?ggtgccgggc??44940
acgccccggt?cctcgctgta?gagggattcc?acgtcccagc?cacggtcgga?ggggaagtcc??45000
ccgaccgcgt?cgacgccgtc?ggagacgacg?ctccacaggt?cctcggggga?cgtgacgccg??45060
cccgggtagc?ggcaggccat?gccgacgatg?acgaccgggt?cgtcggccac?ggagggcagc??45120
gccgcgacgg?ggaccgccac?ggccggctcg?gtgccgagga?cgccgtcgag?gaggtgaccg??45180
gcgaggaggt?cggcggtcgg?gtagtcgaag?acgaccgtcg?cgggcaggcg?caggccggtg??45240
accttgccga?gccggttgcg?cagttccaca?gccgtcaggg?aatcgaaacc?gaggtcctgg??45300
aaggcgcggt?gcgggttgac?ggtctgggca?ccggaatggc?cgaggacgac?ggcgatctgg??45360
ccacggacca?ggtcgagcag?cacctcgcgg?cgctcggcct?ccgcgaggcc?ggcgaggcgc??45420
gcggccaggc?cggtggcggc?ggcaccggct?gcggcggcgg?tgcggcggac?ggaggtgcgg??45480
atcagcccgc?tgagcagcgg?cggcacctca?ccctgggcgc?gcagcgccgg?gaggtcgagg??45540
cggacgggaa?gcacgaccgg?ctcacccgaa?gccagggccg?cgtcgaacag?ggcggtcccc??45600
tgctcggcct?cgaccggcgg?cagaccggac?cgggcgatac?gccgccggtc?ggtctccgac??45660
aactcccgcg?tcatccccgc?gtcctgcgcc?cacggacccc?agacaagaga?gacaccaggg??45720
agccccaggg?cccgccggta?ctccaccaac?gcgtccagga?acacgttccc?cgccgcgtac??45780
gcgccctgcc?ccgcactccc?gaacgtcccc?gccaccgacg?agaacaccac?gaacgcctca??45840
aggcccaggt?cccgcgtcgc?ctcgtgcagg?ttccacgccg?cgtccacctt?cggacgcaac??45900
accgccgcga?cgcgctccgc?cgtcagcgat?gcgagcgtgg?cgtcgtcgat?gacgccagcc??45960
gcgtgtacca?ccgcgcgcac?gccgtgccgg?gtgacgagcc?cggcgacggc?atcggcgtcg??46020
gcggcgtcgc?atgcctcgac?ggccacgtgt?gcgccggcct?ccgtcagttc?ggtgacgagt??46080
tccccggcgc?cctcggcgtt?ggcaccgctc?cggctgacca?gcagcaggtc?ccgcactccg??46140
tgcgtcatga?cgaggtggcg?ggccagtacc?cggcccaggc?cgccggtacc?gccggtgatc??46200
agcaccggac?cggtgagggc?gtcccagcgc?aggccctcgg?ttgcttccgg?tgtgacgcgg??46260
gccaggcgcg?gcacccgcac?ctcgccgtcc?cgcaccaccg?actccgcctc?gccggaggcg??46320
agcgcggagc?ggagggacgc?ggtgtccgcg?tcggccggaa?gctccaacag?gccgaatcgg??46380
cccgggtgtt?cggagatcgc?ggagcgcacc?agcccccggg?cggcggcgtc?ggcgagtccg??46440
gtggtgcggt?cggtggaggc?cgtgacgaag?accaggcggg?atccggcgaa?ccggtcctcg??46500
gccagccacg?accgcaccag?ggcgagagcc?cgggcggcgg?cggtgtgcgc?ggcctgggcc??46560
ggatcggtcc?cgtcggcgtc?gtcggaggcg?gccaccagca?ccgtggaggg?catctcctcg??46620
gcggccgcca?gctcctccaa?ggtggcgtac?gtgacgaagt?cgtcggcggc?cggcacggcg??46680
ctccgggcct?cgccgaggac?ggccaccgca?ccggtgtcgg?caggaccgtc?cagcggccgg??46740
gccgggaccc?actccacctg?gtagagggag?tcccgcgccg?gggtggtgag?ctgtcccgtg??46800
gcgagcgggc?gcaccgtcag?ggagtggaca?gtggcgaccg?gggaaccagc?ggggtcggcg??46860
agggcgaggg?ccatggtgcc?gtcggcgtcc?cgggtgagac?ggacgcggag?ggccgtggcg??46920
ccggaggcat?ggagggaaac?gccgccccag?gagaacggga?cacctccacg?gccgtcgtcg??46980
gcgagggcga?aggcgtgcag?cgcggcgtcg?aagagcgcgg?gatgcaggcc?gaaggcgtcg??47040
ccgtcggtcc?ccccgtccag?ggcgacctcg?gcgtacaggg?cgtcgccgtg?ccgccaggcg??47100
gcccgcagcc?cccggaaggc?ggggccgtag?gcgaagccgg?cctcggccag?gcgctcgtag??47160
cagtcggtca?cgtcgacctg?ggccgcgtcg?cgcggcggcc?agacggtggc?gtcgaagggg??47220
tcgggggcga?gggtctcggg?ggcgagggtt?ccggtggcgt?ggacggtcca?cggagcaccg??47280
tcgtcgtcct?cggtgcgcgc?gtgtacgccg?agggcacggc?ggccgtcctc?gtcgggagcg??47340
gcgacccgta?tctggatctg?gagggcgccg?cgttcgggca?ggaccagcgg?ggcggagagc??47400
gtcagttcct?cgaccgatcc?gcagcccgcc?tcgtcggcgg?cacggacggc?catctccagc??47460
agggccgtgc?ccggcaccag?cacggtgccc?tggacgacgt?ggtccgcgag?ccacgggtgc??47520
gaccgcgtcg?acaggcgtcc?ggtgaggacc?accccgtccg?cgccgtcggc?gccggcgagt??47580
tcgacggccg?cgccgagcag?cgggtgaccg?gcggagccga?gacccgcgaa?gcgcacgtca??47640
ccggcgcgcg?ggagcgtggc?ctcgggccag?tagcgctgct?tctggaaggc?gtaggtcggc??47700
aggtcgacgg?ggcgggcgcc?cacgaggaag?ccggaccagt?cgacgtccac?gccgacggtg??47760
tggagccggc?cgagggcgct?gagcgccgag?cccgtctcct?cgcggtcctt?gcgcaggagc??47820
gggacgagga?cggcgtcctc?accggcgctc?tcgcgcgcca?tgccgctgag?cacgccgtcg??47880
gggcccacct?ccacgaaccg?ggtgacgccc?tcttccgcga?gggcccggac?accgtcgtcg??47940
aaccggacgg?cctcgcggac?gtgggtgacc?cagtactcgg?gctcgtccac?ctgtcccggt??48000
tcggcgagcg?tgccggtgat?gttcgagacc?agcgggatcc?tcggcgccgc?gaaggacagc??48060
ccctccacca?cctcgcggaa?cgcgtggagc?atcggctcca?tcagcgggga?gtggaaggcg??48120
tgcgagacgc?gcagccggct?gacccggcgg?cccagctccc?ggaagacctc?ggcgaccgac??48180
tcgacggagg?cctcggagcc?cgagacgacc?accgaggacg?ggccgttgac?ggcggcgatg??48240
gacaggttgc?cggtgaggtg?cggcagtacc?tcggcgcacg?tggcctcgac?cgccgccatg??48300
gcgccgccct?cgggcagcgc?ctgcatcaga?cggccacggg?cggcgacgag?cgcggcggcg??48360
tcggcgaggg?tgaacacccc?ggccacgtgc?gcagcggcga?cctcaccgat?ggagtgaccg??48420
gccacgaact?ccggccgcac?cccccacgac?tcgaccagcc?ggaacaacgc?cacctcgacg??48480
gcgaacagac?ccggctgggc?gtacgccgtg?cggttcagga?gttcggcgtc?gtcgccccac??48540
acgacctcgc?ggagcgggcg?gtccaggtgc?tcgtccagct?cggcgcagac?cgcgtcgaac??48600
gcctcggcga?ggacggggaa?ccgttcgtac?aggtcacgcc?ccataccgag?ccgctgggag??48660
ccctgcccgg?ggaagaggaa?ggcggtgcga?ccgttcccgg?ccacgccttc?cgcgacggcg??48720
gcgtcgggag?ccccggcggc?cagcgcgcga?agggacgtca?gcgccgtttc?caggtcggcg??48780
cccaggacca?ccgcgcggtg?gtcgaagagg?gtgcgctgcg?tggccagaga?gagcgccacg??48840
tcccgtacgt?ccgccggcgc?gtcggtgagg?aagtcggcca?ggcgggcggc?ctgggcgcgc??48900
agtgcctcct?cggtacgagc?cgacaggacc?cacggctgga?caccggacga?tgcctccgtc??48960
ccgtctgcct?ctcccgggcc?cgacccggtg?accggctcgg?gctgttcgag?gatgacgtgg??49020
gcgttggtgc?cgctgatccc?gaacgaggac?acaccggccc?ggcgagcccg?ctcctccccc??49080
ggccacaccc?gctcaccggt?cagcaactcc?acagcaccgg?ccgaccagtc?gacgtgcgac??49140
gacggagcat?ccacatgcag?cgtgcgcggc?agcctgccgt?gacgcatcgc?catcaccatc??49200
ttgatcacac?ccgccacacc?ggcggcagcc?tgcgtgtgcc?cgatgttgga?cttgacggaa??49260
ccgagcagca?acggccgctc?ctcgtcccgg?ccctgcccgt?acgtcgccag?gagcgcctgc??49320
gcctcgatcg?ggtcacccaa?cgtcgtcccc?gtaccgtgcg?cctccacgac?atccacatca??49380
ccggccgaca?gaccaccact?cgccagagcc?tgacggatga?cccgctgctg?ggaaggaccg??49440
ttgggcgccg?tcagaccgtt?cgacgcaccg?tcctggttca?ccgccgaacc?acgcaccacc??49500
gccagcacac?gatgaccgtt?gcgccgggca?tccgacagac?gctccagcac?caccatgccc??49560
acgccctcgg?accagcccac?accgtcagcc?gagtccgcga?acgaacggca?ccgcccgtcc??49620
gccgacagac?caccctgacg?cgagaactcc?acgaacgtcg?atggcgtcga?catcaccgtc??49680
acaccaccgg?ccaccgccaa?cgagcactca?cccgaacgca?acgcctgcgc?agcccagtgc??49740
aacgccacca?acgacgacga?gcacgccgtg?tccaccgtca?ccgccggacc?ctcgaacccg??49800
aacgtgtacg?aaacacggcc?cgaggccaca?cttccggcac?taccgctgcc?ctggtacccc??49860
tcgtactccg?gggaggccag?caggttggcg?tagtcgtggt?acatgacgcc?ggcgaagaca??49920
ccggtctggc?tgccgcgcag?ggagaccggg?tcgataccgg?accgctcgat?cgcctcccac??49980
gtcgtctcca?gcagaagacg?ctgctgcgcg?tccgtggaga?cggcctcacg?cgggctcatc??50040
ccgaagaact?ccgggtcgaa?ctcgggcgcg?tcgtgcagga?agccaccaga?acgcgtgtag??50100
gaggtgcccg?gcacagcgcg?gtcggggttg?tagagcgcgt?ccacgtccca?gcctcggtcc??50160
gaggggaagt?ccgagaccgt?gtcgacgccc?tcggagacga?cgcgccacag?gtcctccggc??50220
gaggagacgc?caccggggta?gcggcaggcc?atgcccacga?tcacgatcgg?gtcctcggcc??50280
accgacggca?gcgccgacac?cggcaccacc?gccgccggct?ccaccccacc?gaacagttcc??50340
tccagcaggt?accccaccaa?cgcgttgacc?gtcggatagt?cgaacaccac?cgtcgccggc??50400
aaccgcaacc?ccgtcgactt?ccccaaccgg?ttccgcaact?ccaccgcagt?caacgaatca??50460
aaacccagat?cctgaaacgc?acgccccgga?tccaccgact?gcacacccgc?atgacccaac??50520
accacagcga?cctgaccacg?caccagatcc?agcaacacct?cacgacgctc?atctacgccc??50580
aacgccccaa?gacgctgcac?cagaccagcc?gccgccaccg?aaccacccgc?agccgcacga??50640
cgaccacgcc?gccgcaccag?accccggaag?agagccggta?cgtcctcctc?accgcgcagg??50700
gcggccaggt?cgaggcggac?ggggaggacg?accggctcac?ccgaggccag?ggccgcgtcg??50760
aagagcgcgg?tcccctgctc?ggcctcgacc?ggcggcagac?cggaccgggc?gatacgccgc??50820
cggtcagtct?ccgacagtcc?tcgtgtcatc?cccgcgtcct?gcgcccacgg?accccacacc??50880
agcgacacac?cgggaagacc?cagagaacgc?cggtactcca?ccaacgcgtc?caggaacacg??50940
ttccccgccg?cgtacgcgcc?ctgccccgca?ctcccgaacg?tccccgccac?cgacgagaac??51000
accacgaacg?cctcaagatc?aaggccacgc?gtcgcctcgt?gcaggttcca?cgccgcgtcc??51060
accttcggac?gcaggaccgc?agcaacccgc?tccgccgtca?gcgactcggc?catgccgtcg??51120
tccaggacgc?ccgccgcgtg?cacgacggcg?cgcaccgggc?ggtcggccgg?tactccggcc??51180
agcagggcgt?cgagcgcggt?gcggtcggcc?aggtcgcagg?cggcgaccga?cacccgggcg??51240
ccgaggccgg?tcagctccgc?ggtgaaggcg?tcgacgccct?cggcggcggc?accgctccgg??51300
ctcacgagca?gcaggtcccg?caccccgcgc?tcgaccacca?ggtgccgggc?gacgatccgc??51360
cccagcccac?ctgtgccgcc?ggtcagcagc?acggtgccgg?agccgagacc?ggccgacgat??51420
cccgcggtct?cctctccccc?ggcgtccggc?gtcgtgcgga?ccaggcgcgg?gacgcacacc??51480
tcgctgtcca?gcacggccgt?ctccggctcg?tccacggcga?gggccgcgaa?cagccgcccc??51540
gcgtccgtac?ccgccgggag?gtgcagcagg?ccgaagcggc?cggggtgttc?cagcgccacg??51600
gaacgcacca?gaccgcgtac?gggcgcgcta?gtcagagcgg?aggcgggctc?cgtgacgtga??51660
ccgcctcggg?tgatgaagac?cagccgggag?ccggcgaacc?gctcctgcgc?cagccactcc??51720
ttgaccaggg?cgagcgccca?ggcggccgag?gcgtgcgcgg?agcccacgac?gccctcggtg??51780
tccggggcgg?gcggaacggc?gaccacgacc?gtctccggca?ccgcctcggc?cgcggccagc??51840
tcctgcaggt?cggcgcggac?ggctgcgccg?tcgcccgcga?gatcggcgag?gccctcgccg??51900
aggaggacga?cggatcccgc?tgcgggagtc?gcacgcgtgc?cccgggccgg?gacccactcc??51960
acgcggtaca?gcggttcggc?ggtgtcggcc?gcgcgggcac?cggcggcggc?gcggacggtg??52020
agggagccga?ccgaggcgac?gggggctccg?gtcgggtcgg?ccacgtgcac?ggccagcgtg??52080
tcgtcaccgg?tccgggtcag?ccgggtccgc?aggacggagg?cgccggacgc?gtgcagggtg??52140
gcgttctccc?agacgaaggg?caccccgccg?ggcgcgtcgt?cgccgccgaa?ggcgaaggag??52200
gcgtgcaggg?cggcgtcgaa?gagggccggg?tgcaggccga?aggcggtggc?gtcgacaccg??52260
tcgggcaggg?cgacctcggc?gaacacctcg?tcgtcccggc?gccaggcggc?ccgcagcccc??52320
tggaagacgg?ggccgtagcg?cagtccggcc?tcggccaggc?tctcgtagca?gtcggtcacg??52380
tcgaccggca?cggcgtcccg?tgggggccat?acggaggcgt?cgaagccttc?ggccgccggg??52440
tccgcgtcga?tggtctccgg?ggcgagtacg?ccctgggcgt?gcaggctcca?gggctgccgt??52500
tcgtcgccgt?cgtcccggga?gtggatcgcg?acggtgcggc?ggccggattc?gtcaggttcg??52560
ccgacgccca?cctggacgcg?cacggcgccg?cgctcgggca?gcaccagggg?cgcggacagg??52620
gtcagctcct?cgaccgatcc?gcagcccgcc?tcgtcggcgg?cgcgcacggc?catctccagc??52680
agggccgtcc?ccggcaccag?cacggcaccc?tggacgacgt?ggtcggcgag?ccacgggtgc??52740
gaccgtgtcg?agaggcgtcc?ggtgaggatc?agaccgtcgg?cgccggccag?ctccacggcc??52800
gcgccgagca?acgggtgccc?ggccgcaccg?agtccggcga?ggcggatgtc?cccggtcccg??52860
gtggtcgttc?ccgtgggcca?gtagtgctcg?tgctggaacg?cgtaggtggg?caggtcgacc??52920
gcgcggccgc?ccgtgccgtc?gaggacggcg?ccccagccgg?cggagacgcc?ccgcacgtgc??52980
agttcggcga?gggcgctcag?tgcgacggcc?acttcctcgc?ggtccttgcg?caggagcggg??53040
acgaggacgg?cgtcctcacc?ggcactggcc?cgcgccatgc?cactgagcac?cccgtcggga??53100
cccagctcca?cgaaccgagt?gacgccctct?tccgcgaggg?cccgcacacc?gtcgtcgaac??53160
cggacggcct?cacggacatg?ccgcacccag?tagtccggcg?cggtcagttc?acccggctcg??53220
gcaatccggc?ccgagacgtt?cgagacgacc?ggcaggcgcg?gctcggcgaa?cgacagatcc??53280
cgcaggacct?cgtggaacgc?gtcgagcatg?ggctccatga?gcggcgagtg?gaaagcgtgc??53340
gacacgcgca?gtcggctgac?ccgacgcccc?agctcacgga?acacctccgc?caccgcctcg??53400
acggcttcct?cggcgcccga?gacgaccacg?gacgacggac?cgttgaccgc?agcgaccgac??53460
acaccctcga?cggactccag?acgcggcagc?acctccgcct?ccgacgcctc?cacagccacc??53520
atcgcgccgc?cctccggcaa?cgcctgcatc?aaccgcccac?gagcagccac?cagaacacac??53580
gcgtccgcca?gcgagaacac?acccgccaca?tgcgcagccg?ccacctcacc?gatcgaatga??53640
ccggcaacga?actccggccg?cacaccccac?gactcgacca?gccggaacaa?cgccacctcg??53700
acggcgaaga?gaccggcctg?cgcgtacgcc?gtcccgtcca?gaaccgacgt?gtcgtcgccc??53760
cagaccacct?cacgcagcgg?gcggtccagg?tgcgcgtcga?gtccggcgca?gaccgcgtcg??53820
aacgcctccg?cgaacaccgg?gaaacgctcg?tacagaccac?gccccatccc?cagacgctgc??53880
gacccctgcc?ccgagaacag?gaacgcggtg?cggccgggct?cgacggcgcc?gaggacgacg??53940
gcggggtcgg?gctcaccgac?gcagacggcc?gcgaggccac?ggacggcggt?ctcgcggtcg??54000
tccgtcagga?ccacggcgcg?gtggtcgaag?agggaacgct?gcgtggccag?ggagagcgcc??54060
aggtccacgg?gacgcaggcc?ggggtggccc?tcgacctggg?ccagcagccg?ggcggcctgg??54120
gcgcgcagcg?cctcctcggt?acggcccgac?aggacccacg?gcacgatgcc?gggggcgagg??54180
gcggcgatcc?cgtccccgcc?ggtctcgggt?tccgcgaccg?gctcgggctg?ttcgaggatg??54240
acgtgggcgt?tggtgccgct?gatgccgaac?gaggacacac?cggcccggcg?cagccgctcc??54300
tcccccggcc?acacccgctc?accggtcagc?aactccacag?cgcctgccga?ccagtcgacg??54360
tgcgacgacg?gagcatccac?atgcagcgtg?cgcggcagcc?taccgtgacg?catcgccatc??54420
accatcttga?tgacacccgc?gacacccgcc?gcagcctgcg?tgtggccgag?gttcgacttc??54480
accgaaccga?gccagagcgg?ccggccctcc?tcacgctcct?gcccgtacgt?ggccaggagt??54540
gcctgcgcct?cgatcgggtc?acccagcgtc?gtccccgtgc?cgtgcgcctc?cacgacgtcc??54600
acatcaccgg?ccgacagacc?accactggcc?agagcctgac?ggatgacacg?ctgctgggag??54660
ggaccgttgg?gcgccgtcag?accgttcgac?gcaccgtcct?ggttcaccgc?cgaaccacgc??54720
accaccgcca?gcacacgatg?accgttgcgc?cgggcgtcgg?agagacgctc?cagcaccacc??54780
atgcccacac?cctcggacca?gcccacaccg?tcagccgagt?ccgcgaacga?acggcaccgc??54840
ccgtccgccg?acagaccacc?ctgacgcgag?aactccacga?acgtcgtcgg?cgtcgacatc??54900
accgtcacgc?caccggccac?cgccaacgag?cactcacccg?aacgcaacgc?ctgcgcagcc??54960
cagtgcaacg?ccaccaacga?cgacgagcac?gccgtgtcca?ccgtcaccgc?cggaccctcg??55020
aacccgaacg?tgtacgagac?acggccggac?gcgatgctgg?gtgcgctgcc?gttgctgcgg??55080
aagccctcat?accgctcgtc?ggcgagcatg?ttgccgtagt?cgttgtacat?gacaccggcg??55140
aagacgcccg?tctggctgcc?gcgcagggag?gccgggtcga?taccggaccg?ctcgatcgcc??55200
tcccacgtcg?tctccaggag?aagacgctgc?tgggagtcgg?tcgccaccgc?ctcgcgcggg??55260
ctcatcccga?agaactcgga?gtcgaaggct?ccggcgtcgt?gcaggaagcc?accggccttg??55320
gtgtaggtgg?taccggacgc?gtcccggtcg?gggttgtaga?gcgcgtcgac?gtcccagcct??55380
cggttgacgg?ggaactcgga?gacggtgtcg?acgccttcgg?agacgacggt?ccagagatcc??55440
tccggcgagg?agacaccgcc?cgggtagcgg?caggccatgc?ccacgatcac?gatcgggtcc??55500
tcggccaccg?acggcagcgc?cgacaccggc?acgaccgacg?caggctccac?cccgccgaac??55560
agctcctcca?gcagataccc?caccaacgcg?ttgaccgtcg?gatagtcgaa?caccaccgtc??55620
gccggcaacc?gcaaccccgt?cgacttcccc?aaccggttcc?gcaactccac?cgcggtcaac??55680
gaatcgaaac?ccagatcctg?aaacgcacgc?cccggatcca?ccgactgcac?acccgcatga??55740
cccaacacca?cagcgacctg?accacgcacc?agatccagca?acacctcacg?acgctcatct??55800
acgcccaacg?ccccaagacg?ctgcaccaga?ccagccgccg?ccaccgaacc?acccgcagcc??55860
gcacgacgac?cacgccgccg?caccagaccg?agcatcatcg?ggtgcaggtc?accctgcccc??55920
cgcagggcgg?ccaggtcgag?gcggacaggg?aggacgaccg?gctcaccgga?ggccagggcc??55980
gcgtcgaaga?gcgcggtccc?ctgctcggcg?gtcagctcgg?gcatgcctgc?gcgggcgacg??56040
cggtgccggc?tggtcccgga?gagggtgccg?atcatgccgg?cgtcctgggt?ccacgggccc??56100
caggcgagcg?aggtcgcggg?caggccgagg?ctgcggcggt?ggcgtaccag?ggcgtcgagg??56160
aaggtgttgc?cggccgcgta?gttggcctgg?ccggggccgc?cgaggatgcc?ggacatcgag??56220
gagaagacga?cgaaggcttc?gaggtcgagg?gcgcgggtgg?cctcgtgcag?gttccacgcg??56280
gcgtccgcct?tcgggcgcag?gacgcgggtc?acgcgctcgg?ccgtgagtga?ttccaccgtg??56340
ccgtcgtcca?gcaccccggc?ggagtggacg?accgcgcgca?ccgggtggcg?ggcgaccagc??56400
tccgcgacgg?cggcggggtc?ggagacgtcg?cacgcctcga?cggtcacgtg?cgcaccggtc??56460
tcggacagtt?cggcgaccag?ttgcccggcg?ccgtcggcgg?cggcgccgct?gcggctcacc??56520
agcagcaggt?cccgcacccc?gcgctcgacc?accaggtgcc?gggcgacgat?ccgccccagc??56580
ccacccgtac?cgccggtcag?cagcacagtg?ccgtcgatgc?tgtcccagcg?cgggcccgtc??56640
gtggtgccgg?aggtgatccg?ggccagtcgc?ggggcgagca?cctcgccgtc?gcgtgcggcg??56700
gtctccggct?cgcccgtggc?gacggcggcc?agcacggtcg?cggtgtcggt?gccgcgtccc??56760
acctccatca?ggccgaagcg?gccggggtgc?tcggagacgg?cggagcgcac?caggccccgg??56820
agggccgcgt?cggccaggtc?gccgccgtcg?acggcgtccg?aggtgacgaa?gaccaggcgg??56880
gagtcggtga?accgctcctg?cgccagccac?tcgcgcacca?gctccaggcc?acgggcggcc??56940
agggcgtgga?cggcgtccac?caccgcgtcg?ggccgcgtcg?cggcgtcggg?acgcacccgg??57000
accagcaccg?tcgccggtac?ctcttcggcg?gcggccaggt?cctccaggtc?ggggaaggcc??57060
acgaacccgc?cgtccgacag?cccgtcggcc?cggaggactc?ccgcaagggc?cgtggacgcg??57120
tcggaatccc?cgaggacgcc?gaccggaccg?gtgccggccg?cgtcaccagg?tgcctcggtc??57180
cggacccagt?ccacccggaa?gagggcgtca?cgggtcaggg?cgtcgacacc?ggtggcgtcg??57240
ggggcgaccc?ggcggagcac?caggttctcg?acgctggcga?cgggcgcacc?ggtggggtcg??57300
gccacggcga?ccgtcacggt?ctcgtcgccg?gtccgggtca?tccggacccg?gacctcccgg??57360
gcgccggtgg?cgtgcaggca?caccccttcc?caggagaacg?ggaccacacc?gtgcgcgaga??57420
ccacccaggg?ccgagacgtg?gagggaggcg?tcgaggagcg?ccgggtggag?gccgtaggcg??57480
gtggcgtcgc?gctcggcgga?gtcgggcagg?gcgacctcgg?cgaagacgtc?gtcgccccgg??57540
cgccaggcgg?cccgcagacc?ctggaagagc?ggcccgtacc?ggtagccgcc?ctcggccatg??57600
cgctcgtaca?ggccggtgag?gtcgagggat?tcggcgtcgg?cggggggcca?caccgaggtg??57660
tcgaactcca?cggtgcgctc?cccgggagcg?aggacaccgg?tggcgtgctc?ggtccagggc??57720
tggtcgtcgg?cgccctcggc?gcgggagcgg?gccgcgagga?cgcggcggcc?ggcggcgtcg??57780
gcggggccca?cgtgcaggtg?gagctggacg?ccgccctgct?cgggcaggac?cagcggggcg??57840
gcgagggtca?gttcctcgac?acggtcgcag?ccgacctcgt?cgccggcgcg?gaccgcgagt??57900
tccacgaagg?ccgtgccggg?cagcagcgcg?ttgcccatga?cgacgtgctc?gccaagccag??57960
gggtgggtgc?gcagcgacag?ccgggtggtg?agcaggaggc?cgccggagtc?ggagagttcg??58020
acggcggcgc?tgagcagggg?gtgcccggcg?gcgcgcagtc?cggcggactc?cacgtccccg??58080
gcgggtgcag?gtgcgggcac?gggccagtag?tgctcgtgct?ggaaggcgta?cgtgggcagg??58140
tcgacgaggc?gggcgccggt?cccggcgagg?acggcggtcc?agtcgacggg?cgcaccggtg??58200
gcgtggaggc?ggcccagcgc?ggcgagcgcg?gtgacctcct?cgtcacggtc?cttgcgcagg??58260
agcgggacga?ggacggcgtc?ctcaccggca?ctgacccgcg?ccatgccact?gagcaccccg??58320
tcgggcccca?gctccacgaa?ccgcgcgaca?ccctccgccg?ccagagcctg?gacaccgtcg??58380
tcgaaacgca?cggcctcgcg?gacatgccgc?acccagtagt?ccggcgtggt?cagttcaccc??58440
ggctccgcga?tccggcccga?gacgttcgag?acgaccggca?gcgaaggctc?cgcgtacgac??58500
aggccggcca?gagcctcacg?gaagtcaccg?agcatcggct?ccatcagcgg?cgagtggaaa??58560
gcgtgcgaca?cccgcagcct?gctgacccgg?cgtccctgct?cacggaacac?ctccgccacc??58620
gcctcgaccg?cgtcctcggc?gcccgaaacg?accaccgacg?acggaccgtt?gaccgcagcg??58680
accgacacac?cctcgacaga?ctccagacgc?ggcaacacct?ccgcctccga?cgcctccaca??58740
gccaccatcg?cgccgccctc?cggcaacgcc?tgcatcaacc?gcccacgagc?agccaccaga??58800
acacacgcgt?ccgccagcga?gaacacaccc?gccacatgcg?cagccgccac?ctcaccgatc??58860
gaatgaccgg?caacaaactc?cggccgcaca?ccccacgact?caaccagccg?gaacaacgcc??58920
acctcgacgg?cgaagagacc?cgcctgcgcg?tacgccgtcc?cgtccagaac?cgacgtgtcg??58980
tcgccccaga?ccacctcacg?cagcgggcgc?tccaggtgct?cgtccaaccc?ggcgcacacc??59040
gcgtcgaacg?cctccgcgaa?caccgggaaa?cgctcgtaca?gaccacgccc?catccccaga??59100
cgctgcgacc?cctgccccga?gaacaggaac?gcggtggagg?cgctgcggac?ggcgtcctcc??59160
aggacagcgg?ggtggggttc?gtcggcggcg?agggaggtga?gagctgcttc?ggtggttccg??59220
gggtcggtgg?cgaggacgac?cgcgcggtgc?gggagcgggg?cgcggctggt?ggcgagggag??59280
agggcgatgt?ccgccgggcg?cggggactcg?gggccggtgt?ggtcggtgag?gtgggccagg??59340
agtcgtgccg?cctgggcgcg?tagcgcggtc?tgcgaacggg?cggagaggag?ccagggggtg??59400
accgccgggt?cggtggccgt?caccggttcg?gcgggggtgg?cgtcctgagg?ggtgtcctcg??59460
gccccggcgg?gttcgggggt?ggcctgttcg?agcaggacgt?gggcgttggt?gccgctgatg??59520
ccgaaggcgg?agacgccggc?ccggcgggga?cggtcggcgt?cgggccagtc?gacggcctcg??59580
gtgaggagtt?cgacggcgcc?ggccgtccag?tcgacgtgcg?gggtgggggt?gtcgacgtgg??59640
agggtggcgg?gcagcaggcc?gtgccggatg?gccatgacca?tcttgatgac?gccggcgaca??59700
ccggcggcgg?cctgggcgtg?gccgatgttc?gacttgatgc?cgcccagccg?cagcgggcgg??59760
tcctccgggc?ggttctggcc?gtaggtggcg?aggagtgcct?gggcctcgat?ggggtcgccc??59820
agggtggtgc?cggtgccgtg?cgcctcgacg?gcgtcgacct?ggtcggcggc?gaggcgggcg??59880
tcggcgagcg?cggcctcgat?gacgcggcgc?tgggagggcc?cgttgggcgc?ggtgaggcgg??59940
ctgctggcac?cgtcctggtt?gacggcggtg?ccgcggacga?cggcgaggac?ggggtggccg??60000
ttgcggcggg?cgtcggagag?ccgctcgacg?agcagcacgc?cgacgccttc?gccccaggaa??60060
gtgccgtcgg?cggcctcggc?gaagggcttg?cagcggccgt?cggtggcgag?gccgcgctgg??60120
cgggagaact?cggtgaagag?ttcggtggtc?ggcatcatgg?cgacgccgcc?ggcgagggcg??60180
agggagcact?cccccgcgcg?cagggcgcgg?accgcgaggt?gcagggcgac?cagggaggag??60240
gagcaggcgg?tgtcgacggt?gaccgccggg?ccctccaggc?cgagggtgta?ggagatccgg??60300
ccggagagga?cgctcatggc?gccgccggtg?aggttgtggc?cctcggtctc?ctcggcggtg??60360
cgggccaggg?agccgtagtt?ggtgtcggcg?ccgccgacga?agacgccggt?gtcggtgttg??60420
cgcagggagg?cggggctgat?gcgggcgcgc?tccacggcct?cccaggcggt?ttccaggagc??60480
aggcgctgct?gggggtccat?ggcgagggct?tcacgcgggg?cgatgccgaa?caggtccgcg??60540
tcgaagtcgg?ccgcgccttc?gaggaagccg?ccctcacgga?catagctctt?gccgggggtg??60600
cccgggtccg?ggtcgtagag?gccgtccagg?tcccagccac?ggtccgcggg?gagggggccg??60660
atggcgtcgg?tgccgtcggc?gaccagctgc?cacaggtcct?ccggggagcg?gacaccgccg??60720
gggaaccggc?aggccatgcc?gatgacggcg?atgggctcgc?tctcccgtgc?ctcgaccgtc??60780
tccagccgct?gccgggtgcg?gcgaaggtcg?gtggtgacct?tcttgaggta?gtcgcggagc??60840
ttggcttcgg?agcttgccat?ggggtggatc?ctctgaattc?gggaaggacg?cggtggccgg??60900
ggcgggggac?gggagcggtg?gccgccggcg?cgctcgtgga?cgcgccggcg?gccaggcgcc??60960
gtcaggcgag?cccgagttcg?ttgtcgatga?ggtcgaacat?ctcgtcgtcc?gtggtggtgt??61020
cgaggtcgga?gtcgtcgtcg?ggctcgtcgg?cgtcctggga?ggtggcgtcg?agcttccacc??61080
cgagggcctt?gagtcgctgc?gccaggcggg?cgcggtcctg?gtcgtcgagg?gcggccccgc??61140
cgacggcggc?ctccagggcg?gccagttcgg?cgaagacggc?ctggtcgggt?tcgccggcgc??61200
ctgtgccgag?ttcggtctgg?aggtggcgaa?cgagggcggc?cgggtccggg?tggtcgaaga??61260
tcagggtggt?gggcagggag?agcccggtgt?cggcgttgag?ccggttgcgg?agttcgaccg??61320
cggtcagcga?ggacatcccg?aggtcgagga?agccgcggtc?cgcgtcgagg?gacgcggcgg??61380
aggcgtggcc?gaggacggcg?gcgaggtgac?cgaggaccgt?acggtgcagc?agcgcccgct??61440
gctgggggcc?gctgaggccg?gccagccgct?cacggaggtc?cgccggagcg?ccggtggccg??61500
cgccgggccc?ggagtcggcg?gcgcgtcgta?cggccgggcg?tgccagggcc?cgcagcagcg??61560
ggggcacctc?gtcggcgcgc?agggtgcggg?tgtcgagccg?tacggggacg?aggtgggcgg??61620
tgtccagggc?ggtgctcgcg?tcgaggaggg?cgagcccctg?tccggcggtg?agggggcgga??61680
tgccggagcg?ttccaggcgg?gccagaccgg?tggtgtcgag?ggcgccggtc?aggtcgctgc??61740
ggtcctccca?gaggccccag?gcgagggagt?gcgcgggcag?gccgctcgcc?cggcggtgct??61800
gcgcgagggc?gtcgaggaag?gcgttggcgg?ccgcgtagtt?ggcctggccg?gggccaccgg??61860
cgacgcccgc?gtaggaggag?aacatcacga?aagcggtgag?tttggtgtcg?cgggtgagct??61920
cgtggaggtg?ccaggcggcg?tcggccttgg?gccgcaggac?gtgggcgacg?cggtcggcgg??61980
tgaggccgtc?cagtgtgccg?tcgtccagga?caccggccgt?gtggacgacg?gcggtcaggg??62040
ggtgttcggc?cggtacggcg?tcgaggacgc?cggccagttg?ctcgcggtcg?gcgacgtcgc??62100
aggcgacgat?ctctgcctcg?gcgccgagcg?cggcgagttc?ctcgcgcagg?gccgcagctc??62160
cgggggcgcc?gggcccgcgg?cggctggtga?gcaacaggtg?gcgtacgccg?tggcgggtga??62220
cgaggtgacg?ggcgacgagg?gcgccgaggg?tgccggttcc?gcccgtgatc?agcacggtgc??62280
cggcgccggt?tccctcgccc?cacggagcgg?tggcggcggg?cgcgggggcg?ccctccgggt??62340
gaccggcggg?gaccaggcgc?ggcacggtga?cggtgccggc?ccgtacggcg?aactggtgct??62400
cgccggtgcg?cgcggccgcc?gcggcggcgg?cgatcagggc?gtcggcggcg?ctgtcctcgt??62460
cggtgtcgcc?gggggcaggg?tcgaggtcgg?ccaggaggaa?gcgtccgggg?tgctcggtct??62520
gggcggagcg?gagcaggccc?caggcggtgg?cgtcggcgag?gccggggacg?gtgtcgtccg??62580
ggccggtggc?gacggcgccc?tcggtgacca?ggaggagccg?ggcgtcggcc?aggcgcggct??62640
cccggagcca?ggcggtggac?agcgttaggg?cacgggccgc?agaggtgtgc?gctgccttcg??62700
tcgggtcctc?gccgctgtcg?tggccgtgga?aggcgacgac?cagggcggga?ggtgcggcct??62760
cgtcgttgtc?gagggcggtg?gtgagggcgg?ccaggtcggg?gtggagctgg?acggtggcgc??62820
cgctgcgttc?gagggcggcg?gtgagccgtc?cgggggcacc?gatgacggcc?cacggaccgt??62880
gtggttcggg?ggtggcggag?gaggttgtgt?cggtccacgg?gagccaggcg?acccggtgcg??62940
gggcgtcggg?gccggcggtg?gcggggagcc?ggtcggggcc?ggccgagcgg?gtcacggcgg??63000
tgccggtgag?gacgaggtcg?cctgcggcgt?cgcgggcttc?gacgctccag?gtggcgtcgt??63060
cccccggggt?gaggcgtacg?cggagcctgc?tggcgccggt?ggcgtgcacg?gtgacgtccc??63120
gccaggcggc?gggcaggacc?ggtgcggtcg?cctcctcggt?ggtcgcggcg?agggcgagcg??63180
gggtctgcag?gagcgccggg?tggaggcgga?agcgcgccgc?gtcggcgtgc?gcggcgtcgg??63240
gaagtgcgac?ctcggcgagg?acgtcggtgc?cggcgcgcca?cagggagcgc?accgtgtcga??63300
agggcgcggc?gaggtcgagg?ccgcggtcct?cggcgagggc?gcgcacgggg?gcggggtcgg??63360
ccgcgacggc?gtcggcgggc?ggccaggttc?cggaagcctg?cggggtggtg?gtggggcggt??63420
cggtgaggtc?gccggtcgcg?ttccgcgtcc?agggggtggc?gggctcaccg?gcgtcggcgg??63480
cgtggagcct?tgagtggacg?gagaacggcc?gggagtcggt?gtcggcggcg?gagacggtga??63540
gctggatctc?gacgtgcccc?tcctcgggca?cgacgagcgg?gctgtgctcg?tcgagtgcgg??63600
cgaccacggg?caggccggtc?tcgtcgccgg?cccggaccgc?ccagtccagc?agggcggtgg??63660
tggggacgac?ggcggcgccg?tgggtccggt?gggcgtccag?ccagggctgg?gtggtgaggg??63720
acagggagcc?gctgaggacg?gctccgccgt?cggccaggcg?gacgacggag?tcgaggccgg??63780
ccgggtcgcc?ctggggggtg?ccggcgtcca?gccagtaccg?ccggcgctgg?aaggcgtagg??63840
tcggcaggtc?gacggcggtg?ccgtgggaca?cggcggggcg?ccagtcgacg?gggacgcctt??63900
cgacgtgggc?ggcggcgagg?gcggtcagga?cacgggcggg?gccgccgtcg?tcgcggcgca??63960
gcgagccgag?ggccaccgcg?tcggcgccga?gggcggcgac?ggtgtcctcg?atgccgacgg??64020
tgagcaccgg?gtgcgggccg?cactcgacga?agacgtcgtg?gccctgctcg?acgagggccc??64080
gcagggactc?ctccaggcgg?acggtgccgc?gcaggttgcg?gtgccagtag?gcggcgccga??64140
gtccggtgcc?ggggtgccag?tccgcggtga?cggtggagaa?gaaggggatg?tcgccgtcgc??64200
ggggctcgat?gccgtcgagg?gcggcgggca?ggctctcggc?gagccggtcg?acgtgggccg??64260
agtgggaggc?gtagtcgacg?gggacgcggc?gggcgcggac?gccctgttcc?tcgcaggcgg??64320
cgaggagggt?gtcgagcccg?ccggtgtcgc?cggagaccac?cacggaggag?gggccgttga??64380
cggcggcgac?gcagacgccg?ggcagatcgg?cgaggagggc?ggtcacctcg?tcgtgcgggg??64440
cggtgacggc?caccatgccg?ccgtgtccgg?agagttcgcg?ggcgatggcc?cggctgcgga??64500
ccgcgacgat?cctggcggcg?tcggcgaggg?agagggcccc?ggcgacggcg?gccgcggcga??64560
tctcgccctg?ggagtggccg?aggacggcgg?ccggacgcag?gccgtgggcg?cgccacacct??64620
cggcgagggc?gaccatcacg?gcccaggtga?cgggctggac?gacgtcgacg?cggtcgaggg??64680
cgggggcacc?ctcctcctgg?cgcaggacgg?cggtcaggga?ccagtcgacg?tacggggcga??64740
gcgcctcctc?gcaggcggcg?acgcggtcgg?cgaaggcggg?gctggcgtcg?aggagttcgg??64800
cgcccatgcc?ggcccactgg?gagccctgtc?cggggaagac?gaggacggtc?cggcggtcgc??64860
gaccggcacc?ccggccgccg?gtcaccacgt?gggcggcggg?actgccctcg?gcgagggcgg??64920
cgaggccggc?gcggaagtcg?ccggtggcgc?tcccgacgac?gacggcccgc?ttctccagct??64980
gggcgcggcg?cgtgaccagg?gtgtgggcga?tgtcggcggg?gtcggtcccg?gggtgggcgt??65040
cgaggtgggt?gaggagggcc?ttggcctggc?cgcgcagggc?ggcctcgctg?cgggcggaca??65100
gcacccacgg?caggggcgcg?gggcgggtct?ccgccgcgtc?cggcgccggt?gggctccggc??65160
tcgccgccgt?ccgggccggg?ggcggcgggg?gccctcctcc?aggatgacgt?gggcgttggt??65220
gcccgctgat?gccgaaggag?gagacggcgg?cgcggcgcgg?gcgggaggcg?ggcgcctcgg??65280
gccacgcggt?ggcctcggtc?agcaggcgca?cgccggagtc?cgcccagtcg?acgtgcgggg??65340
tcggcgcgtc?aatgtgcagg?ctctcgggga?gcaggcggtg?gcgcagggcc?agcaccatct??65400
tcatcacccc?ggcgacaccg?gccgcggcct?gggtgtggcc?gaggttggac?ttgacggagc??65460
cgaggaacag?cgggtggccg?ccgtcccggt?cgcggccgta?cgtggcgagg?agcgcctggg??65520
cctcgatcgg?gtcgccgagg?cgggtccccg?tgccgtgcgc?ctcgacgacg?tcgacctcgg??65580
cggcgccgac?acccgcgtcg?gcgagggcct?ggcggatcac?ccgctgctgg?gcggggccgt??65640
tgggggcgct?gaggccgttg?ctggcaccgt?cctggttgac?ggcggagccc?cggaccacag??65700
cgaggacctg?gtggccgttg?cggcgggcgt?cggagagccg?ctcgacgagg?atcaggccga??65760
cgccctcgga?gaagccggtg?ccgtcggcgg?cctcggcgaa?gggcttgcag?cggccgtcgg??65820
cggcgaggcc?gcgctgccgg?gagaagtcca?cgatgatctc?gggcgaggac?atgacggtga??65880
cgccgcccgc?cagggccatg?gtgcattcgc?cgcgtcgcag?ggcctgcagc?gccatgtgca??65940
gcgcgacgag?ggaggaggag?caggcggtgt?cgacggtgac?ggccgggccc?tccaggccga??66000
gggtgtagga?gacgcggccg?gagacgatgc?tgttggcgtt?gccgttgttg?acgtatccgg??66060
cgatctcgtc?ggggacgtgg?gtgacgcgct?tgaggtagtc?gctggaggag?aggccggcga??66120
agacgccggt?gcggctgccg?cgtaccgagc?gggggtcgat?gccggcgcgt?tcgaaggtct??66180
cccaggccgt?ctccaggagg?aggcgctgct?gcgggtccat?ggcgagcgcc?tcgcgggggg??66240
agatgccgaa?gaagtcggcg?tcgaagtcgg?cggcgtcgtg?gaggaagccg?ccctcgcggg??66300
tgcgggagct?gccctggccc?tcggggacgg?agtcgtagag?gcgggcgagg?tcccagccac??66360
ggtcgtcggg?gaagggcgcg?acggcgtcgg?cgccgtcggc?cagcagccgc?cacaggtcct??66420
cgggcgagtg?gatgtcgccg?gggaggcggc?aggccatgcc?gacgatggcg?aaggggtcgt??66480
cgtcgccggg?cgcggcggga?gcgggtgcgg?gcgcggcggg?gagcgcggcc?ggggtgccgt??66540
cggagagttc?gccgtcgagg?tgggcggcga?gggcggcgac?ggtcgggtgg?tcgaagacga??66600
gggtggcggg?cagccgcaga?ccggtggcgg?cgctgaggcg?gttgcgcagt?tcgacggcgg??66660
tcagcgagtc?gaagccgagg?tcgcggaagg?cgcggccggc?gtggaacggc?tcggtgtcgt??66720
cgtggccgag?gacggcggcc?gcgtgggcac?cgaccaggtc?gcgcagggtg?ctgagccggt??66780
cctcggcgga?acggccggcc?aggcgggcgc?gcaggccgtc?ggtaccggtg?gcggcgccgg??66840
cctcggcggt?gcgccggacc?gggccccggt?acagggagcg?cagcaggggc?gggacctcgt??66900
cgccggatgc?gcgcagctgt?ccggtctcca?ggcggaccgg?caccaggtgg?gggcgctgct??66960
cggtgagggc?ggcgtcgaag?aggaccatgc?cgtcggcggc?ggagagcggc?aggacgccgg??67020
agcggcgcac?ccgggcgagg?tcggtgtcgt?cgagctgtcc?ggtcagggca?ctggtgtcgg??67080
cccacagacc?ccaggagagg?gaggtggtgg?gcaggccgtc?ggcgcggcgc?cggtgggcga??67140
gggcgtcgag?gtaggtgttg?gcggcggcgt?agttggcctg?tccggcgttg?ccgaagacgc??67200
cggcgcccgc?ggagaacagc?accaggtccg?tgagatcgag?gtcgcgggtg?aggcggtgca??67260
ggtggcgggc?ggcgtcggcc?ttcggggcga?ggacggtgcg?cagccggtcg?ggggtgaggg??67320
attcgaggac?gccgtcgtcg?aggacgcccg?cggcgtggac?gacggcggtc?agcgggtgct??67380
cggcggggac?ggcggcgagc?accgcggcga?gggcgtcggc?gtcggccgcg?tcgcaggcgg??67440
caagggtgac?ctcggcgccc?agctcccgca?gctcggcggc?gagttccccg?gcgccggggg??67500
tgtcggggcc?ccggcggccg?gtgaggacga?ggtggcgcat?gccgtggcgg?gtgacgaggt??67560
ggcgggcgag?gatgccgccg?aggacaccgg?cgccgccggt?gacgaggacg?gtgccctcgg??67620
ggtcccaggc?gcgcggcagg?gtgagcacga?tcttgccgta?gtgcttggcc?tgggccatgt??67680
ggcggaaggc?ttcgcgggcg?tgccgcacgt?cccaggtgac?ggtgggcagg?ggccgcaggg??67740
ctccggaggc?gaagagttcc?gacaggtcgc?ggaacatctc?ctggatgcgg?tcctcaccgg??67800
cctcacgcag?ttcgtacgcc?tggtagaggg?cggcggcggg?gtggtcgcgg?agaacctgcc??67860
cgggatcgcg?gacatcggtc?ttgcccatgt?cgacgaggcg?cccgccgggg?gcgagcagcc??67920
gcagggaggc?gtcgatgtag?tcgccggcca?gggagttgag?gacgacgtcg?acgccacggc??67980
cgccgctggt?ggtgcggaag?cggtcctcga?aggcgagggt?gcgggaggag?gcgaggtggg??68040
cgtcgtccca?gccgtcggcg?cgcagcaggg?tgcgcttgtg?gtcgccggcg?gtgccgtaga??68100
cctcggcgcc?ccagtggcgg?gcgagctggg?cggcggccat?gccgacaccg?ccggcggcgg??68160
cgtggacgag?gacggactcg?ccggcgtcga?ggtgggcgag?gtcgcgcagt?ccgtagtagg??68220
cggtgaggaa?ggcgacgggg?acggaggcgg?cctgcgccca?ggtccagccg?tcgggtacgg??68280
gggcgagcat?gcgggcgtcg?gcgacggcgc?ggggggcgaa?gccgccggag?accaggccca??68340
tgacgcggtc?gcccggggcg?aagccggtga?ctccctcgcc?gacggcggtg?accacaccgg??68400
ccgcctcggc?gccgaggagc?acggcggggc?cggggtacat?gccgagggtg?ttgaggacgt??68460
cgcggaagtt?gagtccggcg?gctcgcacct?cgatcaccac?ctcgccggcg?gcgggctcct??68520
cggccgtccc?gggggcggcg?acgaggtcca?gccggtcgac?ggatcccttc?tcggggatgt??68580
cgaggcgcca?gttcccggtc?ccctcgggca?cggtgagggc?gtcggaggta?cggggccgga??68640
ccaggcgcgg?cgcgtacgcg?gcgccctggc?ggagggcgag?ttgcggctca?ccggcggcga??68700
gtgcggccgg?cagggcgagc?caggagtcgt?cgtggatgtc?gaggtccacc?aggacgaggc??68760
ggcccgggtg?ctgggactgg?gcggagcgca?ccaggcccca?gacggcggcg?ccgggcaggt??68820
cgtgggcggg?gtcggcgggg?ccggtgggga?cggcgccgcg?ggtgacgacg?accagcggaa??68880
cgccctcggt?ggtctcgtcg?gcgagccagc?tctggacggt?ggcgagcacg?tcgtcgagga??68940
cggcgtccgg?gacgcccggc?tcggcgtcgg?gggcggcggc?cgtgcccgac?gcggcggccc??69000
cggcgaacag?caggacggcg?tccggccggt?gaccgttggc?ctcggtgtgc?tcggccagtg??69060
cgccgggggt?ggcgaaggcg?ggcagtgtgg?ttccgctgcc?gtcgggtgcg?gtgaccgggt??69120
cggccggggt?gccgaggacg?gcccagccgg?tggcggccgg?gacggcggcg?ggcggcgtga??69180
ccggtgtcca?gtcgaggcgg?aacagccagt?cgcgggcggc?gcgggcggac?ggatcgaggg??69240
tgtccggcgc?gatctcgcgt?acggccaggg?cgtcgatggt?ggcgacgggg?gcgccggtcg??69300
ggtcggtgag?ctggacggag?atggcgtcct?gccctgccgg?ggagacgcgg?acgcgcagcg??69360
cggtcgctcc?ggcggcgtgc?aggcagaccc?cgctccaggt?gaacgggacg?accgtgcgcc??69420
cggcgctgcc?gggggcgagg?tgggcggcgt?gcagggcggc?gtcgaggagc?gcggggtgga??69480
tgccgaaccg?tccggcgtca?ccgcggacct?gctcgggcag?gacgacctcg?gcgtagaggt??69540
cctcgccgcg?gctccaggtg?gcgcgtacgc?cctggaagac?gggcccgaac?tcgtagccac??69600
ggccggcgag?cagctcgtag?aagccctcgg?cggcgacggc?ggtggcgccg?gggggcggcc??69660
aggaggtgaa?ctcctcgggc?cggtcgacgg?cgggggcgcc?gggctcggtg?agggtgccct??69720
gggcgcggag?cgtccagagg?tcctcggtgg?cgccgtcggg?gccggtggtg?cgggtgtgga??69780
cggtgacggg?acggcggccg?gaggcgtcgg?gttcgccgac?gccgatctgg?acctgtgcct??69840
cgccgcgttc?ctggaggacc?acgggggcct?ggagggccag?ttcctcgatc?cggccgcagc??69900
cgaggacgtc?tccggcccgg?atcacggact?ccacgagcgc?ggtcccgggg?acgatcacgg??69960
tgccggacac?cgcgtggtcc?gcgagccagg?ggtgggtacg?cagcgaccac?cgtgccgtgg??70020
ccaccaggcc?gtcgccgccc?gcgagttcga?cggaggcacc?gagcaggggg?tgatcgggcg??70080
agtcgaggcc?ggccgagctg?acgtcaccgc?ccagctcggc?gaaacgcggc?cagtagtgct??70140
gccgctggaa?ggcatacgtg?gggaggtcga?cgtggcgggg?ccgggtgccc?gcgtaatgcg??70200
tctcccagtc?cacctcggca?cccagcgccc?acgcctcacc?cagcgacagc?gcgaaccgct??70260
ccagaccacc?ctcgtcacgc?cgcagcgtgc?cgacgacacc?ggcctgcacg?ctcgcgtcct??70320
cgatggtctc?ctgcaccccg?gtggccacca?ccggatgcgc?actcacctcg?acaaacaccc??70380
ggaacccgtc?ggccagcaac?gcacgcgtcc?ccgcctcgaa?ctccaccgtc?ccccgcaggt??70440
tccggtacca?gtacccggcg?tccagaccag?cggtgtcgat?cacgccaccc?gacaacgtcg??70500
agtagaacgg?cacatcacac?gagcgcggcg?ccaccggcgc?cagaagcccg?gcaagctcct??70560
cctcgatgcg?ctccacatgc?gcggagtgcg?acgcgtagtc?caccgccacc?cgacgcgccc??70620
gcacacccga?cgcgtcacac?gcggccacga?actcgtccaa?cgcctccgca?tcacccgaca??70680
ccaccaccga?cgacggccca?ttgaccgccg?ccacactgat?acgcccctcc?cagcccgcca??70740
gcagaccacg?aacctcgtcc?acgttccttg?cgaccgacac?catgccgccc?agacccgaca??70800
gcgcacgcaa?cgcacgcgac?cgcagcgcca?ccacacgcgc?cccgtcctcc?aacgacagac??70860
cacccgccac?caccgcggcc?gcgatctcgc?cttgcgaatg?accgatcacc?gcacccggct??70920
ccacaccctg?agcccgccac?acctccgcca?acgacaccat?caccgcccac?aacaccggct??70980
gcaccacatc?cacccgctcc?aacgacgcag?caccctccac?accgttcagc?acatccagca??71040
acgaccactc?cgtgaacggc?tccaacgccg?ccgcacactc?cgccacccga?cccgcgaaca??71100
ccggcgacga?acccaacaac?tccaccgcca?tacccaccca?ctgcgaaccc?tgacccggga??71160
acacgaaggc?gaccttgccg?gagccgtccc?cgaccgagcc?ttccaccaga?cgcggggaag??71220
gctccccggc?ggcgagcgcg?tccagcccgg?cgagcagttc?ctcgccgtcc?cggccgacga??71280
ccaccgcacg?ccggtccatc?gccacgcggg?aggagaccag?cgcatgtgcc?acgtccagca??71340
ccgacgcgtc?ggacgtacgc?accgacgccg?ccagacgcgc?cgcctgctcc?cccaccgccg??71400
cacgcgactt?gcccgacacc?atccacgacc?ggacggtgtc?ggccgagtcg?tccgcggagg??71460
gctcggtgaa?cgggtcggcc?ggctcgtcct?cggcgggttc?gggggccggg?gcctcctcca??71520
ggatgaggtg?gccgttggtg?ccgctgatgc?cgaacgagga?gacgccggcg?cggcgcggac??71580
ggccggtctc?gggccagggg?gtggactcgg?tgacgaggcg?gacggcgccg?ctcgaccagt??71640
ccacgacgga?ggtcggccgg?gtgatgtgga?ggctcttggg?cagggtgccc?tgccgcatcg??71700
ccaggatcat?cttcatcatg?ccggcgacgc?cggcggcggc?ctgggtgtgg?ccgatgttgg??71760
acttcagcga?accgagcagc?agcggccggg?ccgggtcgcg?gtcctggccg?taggtggcga??71820
ggatggcctg?cgcctcgatg?gggtcaccga?gcggcgtgcc?ggtgccgtgc?gcctcgacca??71880
cgtcgacctc?gcccggggcg?aggcccgcgt?tggcgagggc?ctggcggatg?acgcgctgct??71940
gggaggggcc?gttgggggcg?gtcagaccgt?tggacgcacc?gtcctggttc?agggcggagc??72000
cgcggaccac?ggcgaggacc?gggtgaccgt?tgcggcgtgc?gtcggagagc?cgctccagca??72060
ggaccaggcc?gacgccctcg?gcgaagccca?tgccgtcggc?gccctcggcg?aaggccttgc??72120
agcgcccgtc?ggccgccagg?ccccgctgcc?gggagaactc?gacgtagggc?tcgggtgtgg??72180
acatgacggt?gacaccgccg?gccagggcca?tcgtgcactc?gccggtgcgc?agcgactgca??72240
gggccaggtg?gagggcgacc?atggacgagg?agcagccggt?gtccatggtg?acggcagggc??72300
cttcgaagcc?gtacgtgtac?gacaggcggc?cggaggcgat?gctggaggcg?ttgccggtca??72360
tgaggtggcc?ggcgagttgt?tcctgggcgg?cggcgccgcc?caggcggacc?tggtagtccg??72420
tggtgatgct?gccgacgaag?accccggtgg?cgctgttgcg?cagggttccc?gggtcgatgc??72480
cggcgcgttc?gaaggtctcc?caggaggtct?ccagcaggag?ccgctgctgc?gggtccatgg??72540
ccagggcctc?gcgcggcgag?atcccgaaga?acaccgggtc?gaatccggcg?acgtcctgga??72600
tgaagccgcc?ctcacggctg?taggtggtgc?cgtggcgctc?ggggtccggg?tcgtacaggg??72660
cgtcgaggtc?ccagccacgg?tcctcgggcg?gcgtggagac?ggcgtccacc?tcggcggcca??72720
tgaggtgcca?cagttcctcg?ggcgtggtga?cgccgccggg?gaagcggcag?gccatggcga??72780
cgaccgccat?cggctcgtcg?gtgacgcccg?cggagacgac?gacgggcgcg?gcgacggggc??72840
gctcgtcgcc?gaggagcagg?gtgcgcaggt?gggcgacgac?cgccgtggtg?ttggggtagt??72900
cgaagaggag?ggtggtgggc?agcttgacgt?cggtggcggc?ggtgatccgg?ttacggacct??72960
ccacggcggt?cagcgagtcg?aagcccaggt?ccttgaaggc?acggttgacg?tccacggcct??73020
ccggtgagga?gtggcgcagc?gcggtggcga?cctcggcgcg?gaccaggtcg?gtgagcagcc??73080
ggtcctgttc?ggcgggggcg?aggccgcgca?gccggtcgcg?cagggcgtgg?gtgtcgggcg??73140
cggtggcggc?ggctgcctcc?agggcgcggc?ggacctcggg?gaggtcgccg?acgagcgggc??73200
tgggccgggc?cgcggtcatg?gcggtgccgt?aggcccgcca?gtccacgtcg?aggacggtgg??73260
cgtgcgggac?gccctcggcg?acggcggcgc?gcagcgcggc?gacggcggtg?acggggtcca??73320
tcggggcgag?gccgtcgtgg?ctcatccggt?cggcgagcac?gtcggcggtg?gccatgcccg??73380
cgtcggccca?cgggccccag?gccacggagg?tgacgggcag?gccctcggcc?cgccgctgct??73440
cggctacggc?gtccagatag?gcgttggcgg?cggcgtagtt?ggcctgcccg?gcgttgccga??73500
ggacaccgac?gatcgaggag?aagaggacga?acagggtgac?gtcgtggtcg?cgggtcagct??73560
cgtgcaggtg?ggcggtgccg?agggtcttgg?ggcgcaggac?ggcttcgaag?cggtccaggg??73620
tgagggcgtc?gaggacaccg?tcgtccagga?caccggcggc?gtgcacgacg?ccggtgaggg??73680
ggaggccggc?ggggagggag?tccagcagac?gggcgagctg?gtcgcggtcg?gccacgtcgc??73740
agtcggcgac?ggtgacccgg?gcacccagct?cctccagctc?ggcgacgagt?ccgactgcac??73800
cggggctgcc?gggtccgcgt?cggctggtga?gcaccaggtg?gcgggcgccg?gaggcggcga??73860
gcgagcgggc?cacgtgggcg?ccgagcgcac?cggtaccgcc?ggtgatcagg?acggtgtcgt??73920
ggtcgcccca?gcccccgatc?ccgtcgtcgt?cggccgcccg?cacggcgagt?tccgcgtcca??73980
cgtcggtgac?ccgggccggc?tcgggcagcg?gcattcgggc?cagccgacgg?gcgtacgcgc??74040
cggaggagcg?tacggcgatc?tggtcctcgg?ggccgccgag?gagcgtggcg?aggcgggcga??74100
ggctgcgggc?gtcggggtcg?gcgggcaggt?cggcgaggcc?gccccaggcg?tcggggagtt??74160
ccagggcgac?ggcgcgtccg?aagccccagg?tctcggcctg?gacgggcgag?gtcagccggt??74220
cgcggctgtc?gacggcgacg?gcgccgcggg?tcagcgccca?cacggaggct?tcggtgccgg??74280
acagcgcgtg?cagcagctcc?ttggcggtgg?cgaggccgcg?cggtacggcg?gggtggtcgg??74340
ggtgggggcg?ctcgtcgagg?gcgaggagcg?agaggacgcc?cgcgatgcct?tcggcgccgt??74400
cgggctcggt?gtcaccggtt?ccggtgagca?gggcggtgag?cgcggcggtg?tcctcgtcgc??74460
cggtgaggtc?gtggcgctcg?acacgcaggc?cgcgccccgt?gagagccccc?agcaccgcgt??74520
gcacccaggg?gtcgtcggcg?tggccggcgg?ggacgagggc?gggccagcgg?ccggcgggga??74580
cggcgtcgtc?ggcgccggtc?agcgcggtcc?aggtgacgcg?gtggcgccag?gtgtcgaggg??74640
tggagcgcag?ggtgcggcga?cggcgccagg?acgccagcgc?gggcagcagc?gtgccgaacg??74700
cctccacgtc?gtcgccggtg?acctccagca?cggaggagag?ccgggtgaga?tcgccgctct??74760
cgacggccga?ccagaagtcg?ccgtcggcgg?ggtcgccggt?ggccgccgcc?gcggccgact??74820
cggcgggcgt?cagccagtac?cagtcacggc?ggaacgggta?ggtggggagg?tcgacgtggc??74880
ggggccgggt?gcccgcgtaa?tgcgtctccc?agtccacctc?ggcacccagc?gcccacgcct??74940
cacccaacga?cagcgcgaac?cgctccagac?caccctcgtc?acgccgcagc?gtgccgacga??75000
caccggcctg?cacgctcgcg?tcctcgatgg?tctcctgcac?cccggtggcc?accaccggat??75060
gcgcactcac?ctcgacaaac?acccggaacc?cgtcggccag?caacgcacgc?gtccccgcct??75120
cgaactccac?cgtcccccgc?aggttccggt?accagtaccc?ggcgtccaga?ccagcggtgt??75180
cgatcacgcc?acccgacaac?gtcgagtaga?acggcacatc?acacgagcgc?ggcgccaccg??75240
gcgccagaag?cccggcaagc?tcctcctcga?tgcgctccac?atgcgcggag?tgcgacgcgt??75300
agtccaccgc?cacccgacgc?gcccgcacac?ccgacgcgtc?acacgcggcc?acgaactcgt??75360
ccaacgcctc?cgcatcaccc?gacaccacca?ccgacgacgg?cccattgacc?gccgccacac??75420
tgatacgccc?ctcccagccc?gccagcagac?cacgaacctc?gtccacgttc?cttgcgaccg??75480
acaccatgcc?gcccagaccc?gacagcgcac?gcaacgcacg?cgaccgcagc?gccaccacac??75540
gcgccccgtc?ctccaacgac?agaccacccg?ccaccaccgc?ggccgcgatc?tcgccttgcg??75600
aatgaccgat?caccgcaccc?ggctccacac?cctgagcccg?ccacacctcc?gccaacgaca??75660
ccatcaccgc?ccacaacacc?ggctgcacca?catccacccg?ctccaacgac?gcagcaccct??75720
ccacaccgtt?cagcacatcc?agcaacgacc?actccgtgaa?cggctccaac?gccgccgcac??75780
actccgccac?ccgacccgcg?aacaccggcg?acgaacccaa?caactccacc?gccataccca??75840
cccactgcga?accctgaccc?gggaacacga?aggccacatc?acccgcaccc?tcaccggcgg??75900
tgccctcgac?cacacgcacg?gacggctcac?ccgccgccag?cgcgtccagc?cccgcgagca??75960
gctcctcacg?gtcggacccc?acgaccaccg?cacgccggtc?catcgccaca?cgcgacgaca??76020
ccagcgcatg?cgccacgtcc?agcaccgacg?cgtcggacgc?acgcaccgac?gccgccagac??76080
gcgccgcctg?ctcccccacc?gccgcacgcg?acttacccga?caccatccac?gaccggacgg??76140
tgtcggccga?gtcgtccgcg?gagggctcgg?tgccgggctc?ctccgcgcgg?ggggtctggt??76200
cctcgggggc?ctgttccagg?atgaggtggg?cgttggtgcc?gctgacgccg?aaggaggaca??76260
cggcggcgcg?gcggggccgg?ccggtctcgg?gccaggtggt?ggactcggtg?agcagttcca??76320
cgcccccggt?cgcccagtcg?gcgtgcgggg?tgggcgcgtc?gacgtggagg?ctcttgggca??76380
gggtgccgtg?gcgcatggcc?tgcaccatct?tgatgacccc?ggcgacgccg?gaagcggcct??76440
gggtgtggcc?ggtgttggac?ttcagcgagc?cgagcagcag?cgggtgcgcg?tcaccgcggt??76500
cctgcccgta?cgtgttgagg?agggcctgcg?cctcgatggg?gtcaccgagg?gtggtgccgg??76560
tgccgtgcgc?ctcgaccacg?tcgacctcgc?ccgaggtgag?accggcgtcg?atgagggcct??76620
ggcggatcag?ccgctgctgg?gaggggccgt?tgggggcggt?caggccgttg?gacgcgccgt??76680
cctggttgat?ggcggaaccc?cggatgacgg?cgaggatctc?gtggccgttg?cgctgcgcgt??76740
cggagagccg?ctccagcagg?atcaggccga?cgccctcgga?ccaggcggtg?ccgtcggcgc??76800
cggcggcgaa?gggcttgcag?cgcccgtcgg?ccgccaggcc?ctgctggcgg?gagaactcgg??76860
tgaacatctt?gggcgtcgac?atgacggtgg?cgccgccggc?cagggccagc?gagcattcgc??76920
cctgtcgcag?cgaacggacg?gccaggtgca?gggcgacgag?cgaggaggag?caggcggtgt??76980
ccaccgtcac?ggcgggcccc?tcgaagccgt?acgtgtacga?caggcggccg?gaggcgacgg??77040
cgaccgtgtt?gccggtgagc?aggtgcccgg?cgacctcttt?ctggcgcccg?cgcgaggcgc??77100
cgtcgtagtc?gccgtgcccg?gtgccgacga?agacaccggt?ggtgctgccc?gcgagggtgt??77160
cgggcaggat?gccggcgcgc?tccagcgcct?cccaggaggt?ctccagcagg?agccgctgct??77220
gcgggtccat?ggccagggcc?tcgcgcggcg?agatcccgaa?gaacgccggg?tcgaactcac??77280
cggcgtcgtg?gaggaatccg?ccttcacgcg?tgtaggtggt?gccgtggtgg?gcggggtccg??77340
ggtggaacag?gtggtcgagg?tcccagccgc?ggttcgcggg?gaacgcggag?atggcgtcca??77400
cgccgtcgcg?ggccagttcc?cacaggtcct?ggggggtgcg?cacgccgccg?gggtagcggc??77460
aggccatggc?gacgacggcg?acgggctcgc?ggtcgcggtt?ctcggcgtcg?ctgagctgct??77520
gccgggcctc?ctggagatcg?gtgacggccc?gcttgagata?tgcgcggagc?ctgtcctcgt??77580
tcgacatcag?gtgcccacct?ctccatgaga?taccggaaaa?cgcggaggcg?gcgattcccg??77640
aattccacgc?cccgacccag?ttcgcgctcc?cggaagtcag?gggacccgtc?cgggaaagcg??77700
gccacgggcc?gtacgggacg?gcccggtgcg?agagccagtc?tggccgtctt?ggactgcggg??77760
tttccctaaa?gcatggggag?gctggtgggg?acgcgcgttc?cggtcgaggc?gggttctccg??77820
tccgaggtct?ggtgaattcc?ctcgtcggtt?tccgatatcg?gcggggcgga?tcgccgggcg??77880
gggaattcgc?gacggcggag?ggcggaacgg?ctcggtcgtg?gagccgacga?ggccccgctc??77940
cgtcgaaggt?gacggaacgg?ggcctcgctg?ggtggggggc?agtcagccgg?cgggggcggt??78000
ctccggcgcg?tcggtggtgg?ccgtggtctc?cagggcggtc?agccacgcgt?ccatgaggtc??78060
ggcggcgggg?ccggagtcct?cacggatgag?ggagaggtgg?tcggagtcca?gggggcggac??78120
ctccgcgtcg?gggacgaccg?gaaggtgcag?gcgctcgggg?tcgggggcgg?ggacgccctc??78180
gatgagcgcc?cgggtgcact?tgatctccag?gacggggacg?gtggtggggt?gcacgtcgag??78240
ggcgttgagg?agcaccatcc?agcggcccat?ggcggacagg?cgggagttgg?tcaggcgcac??78300
cggggagtcg?tcgacggcgg?tgaagttgaa?cttcatcatg?ccgttgtagt?cgacgccctc??78360
gtcgctcttg?tgctggatgc?tgagggtgtc?gaggaggacg?acggcctcgg?gccggatgcc??78420
ccaggtgtgt?tccaggactc?cggccgccgc?gtaggcgagg?gagccgccgg?aggagtggcc??78480
gaccaggacg?aagggcttgc?cgtcggcggc?ctggagggtg?cagtcggcga?tgatccgcgc??78540
ggccgcctcg?gcgtgggcgg?gcagggcctc?gccggtgttg?aagccgatga?ggggcagcgc??78600
ggtgacgtcg?cggcggcccc?ggaagtggcc?ggagagagtg?gcgtactggt?ggacgccgcc??78660
gttggcggtg?ggggcgctga?cgcacaccag?gcgggtcggt?gcggggccct?cggcgagcgt??78720
caccggccag?ggcaggtcct?ccagttcggc?ggtcacctcg?aaggaggggc?gcagcgccgc??78780
gacggtggcc?agcatgcgct?gtgcctcgcg?caccttgccc?tgggccaggc?cgtcgaggaa??78840
cagccgctcc?atggagtcgt?tctcggtggg?gccgccggcg?gcgccggtct?gcggggcgcc??78900
gctgccctgg?gcgccgagtt?cggtgcgcag?ccaggcggtg?agcccgttcg?gggagccgct??78960
gtcgtagacg?atgctcgcgg?ggagctggag?accggtgatc?tcgctgagct?tgcggcgcag??79020
ttcgataccg?atcagggagt?cgaagccgag?ctccaggaag?tcgcggtcgg?ggtcgatctc??79080
cgaggtgtcg?gtgtggccga?ggagtgccgc?ggcgcaggcc?acgaccgtct?cgcgcagggt??79140
ggtctcctgc?tcccccgcgc?cgaggttcgc?gaagttctcg?cggaaggagg?ccgcgtccag??79200
gacgcgggcc?ggggcgtcgg?tcgtggcggc?ggcggtccgg?cgcgggggac?ggaccaggcc??79260
ccgcatgagc?ggcggcacct?cgtcgaggtg?ggcggtggcg?ggcggtgcgg?ccaggttggt??79320
ggcgaccacc?aggggttcgc?cgagcgtgag?cgcggtgtcg?agaaggtcca?gggcgcggtc??79380
gccgggcagg?gtgtcgatgc?cgccggagcg?gatgcggcgg?cggccggtgt?cggtgaggag??79440
gtcgccggcc?atgccctcgt?cgaggtccca?ggcgccccag?gccacggaga?gggccggcag??79500
gccctgggcg?gcccggtgct?gggcgagggt?gtcgaggaag?aggttggcgg?cgacgtagtt??79560
ggcctggccg?gcgcgggcgg?tgacgccgga?gatggaggag?tagaggacga?aggcgtcgag??79620
gccgaggccg?cgggtgaggt?cgtgcaggtg?ccaggcggcg?tccgccttgg?accgcaggac??79680
ggtggccagg?cggtccggtg?tgagggaggt?gacgacggcg?tcgtcgagga?ctccggcggc??79740
gtgcacgacg?gcggtgagcg?ggtgctcggc?ggggatgccg?ccgagcagtg?cggccagggc??79800
gtcgcggtcg?gagacgtcgc?aggcggcgac?ggtgacatgg?gcgccgaggg?cggtcagttc??79860
ctcgcgcagg?gcggcggcgc?cgggggcgtc?ggggccccgg?cggcccgcca?gcaggagccg??79920
ggtgacgccg?tggcgggtga?cgaggtggcg?ggcggtgcgg?gcgccgaggg?tgccggtgcc??79980
tccggtcacc?aggacggtgc?cgtcacgggt?gacaccgaac?gggtcggtgt?tctccgggcc??80040
gtcctggggc?gtgggcgggg?gcagttgggt?gaggcggccg?acgaggacct?gtccgtcgcg??80100
gacggcggcc?tgcggctcgt?cgacggcgag?gacggcctcc?agggggaacg?gggcgcccgg??80160
ttcgacgtcg?accagggtga?agtcggcggg?gtgctcggcc?tgggcggtgc?ggaccatgcc??80220
ccacaccgcg?gccccggcca?ggttggcggc?cgggtcgccg?ggacgggcgg?ccacgacgcc??80280
gcgtgcgacg?aagaccagcc?gggcgcccgc?cgggcggggg?ccgtccagcc?actcctggag??80340
gagggcgagg?gtggcgcggg?tcgcctcgtg?ggtggcggtg?accgggtcct?cgcctccgtc??80400
ggggacgggt?acgaggacct?gggtgcccgt?ctcggtgacc?tcgtcgagcc?cggccaggac??80460
cgtaccggtg?ccgaacgggt?cggtgccgag?ggcgacccgg?gggcctccgg?cggcgggccc??80520
ggtgggttcg?gcggggaccc?agtcgaggcc?gaggagggtg?gagcggtcgg?ttccgggctt??80580
gagcaggcgg?gccgccccgg?agggccgcag?ggccagcgac?tcgaccgaca?gcacgggccg??80640
gccggcggtg?tcgacggcgg?cgatgctgac?ggtgtcctca?ccggccttgg?tgatacggac??80700
ccggagccgg?gcggccccgg?aggcgtgcag?ggtgacgccg?gaccaggaga?acggcaggag??80760
tccctggtcg?gcgtccttca?gctcgacgta?ctccacggcg?tggagggcgg?cggtgagcag??80820
ggcggggtgg?agaccgaaga?gggcggcgtc?gtcggcgcgg?gcgggcagtt?cgagttcggc??80880
gaggacctcg?tcgccccggg?tccacacggc?acgcagcccc?tggaagagcg?ggccgtactc??80940
ggtgcgctcg?tagaagccgt?ccaggtcgac?gggggtggcg?tcggcggggg?gccaggcgct??81000
ctggccgaag?gcgacctggc?gtgctccggc?gaccaggacg?ccggtggcgt?gctgggtcca??81060
gggctcgtcg?tcggcggcgt?cctcgggccg?ggagtggatg?gcgagcgggc?ggcagccggc??81120
cgcgtcgggg?ggaccgacgc?cgacctgtac?ggaggcggcg?cctcgcgggt?cgagggcgag??81180
cggggtggtg?agggtcagtt?cctggacgcg?gccgcagccg?gcctggtcgc?ccgcgcggac??81240
ggcgagttcg?aggaaggccg?tggcggggaa?gaggacgagg?ccgcccatga?cgtggtcggc??81300
gagccaggga?tgggtgcgca?ggcccacgcg?cccggtcagc?aggacgccct?cggaaccggc??81360
gagggagacc?gcggcaccga?gcagggggtg?ctcggccggg?gtgagcccgg?ccccggggat??81420
gtcggcggcg?tgggcgagcg?ggcgcggcca?gtagcggcgg?tgctgccagg?cgtacgtggg??81480
caggtcggtg?cggcgggcgc?cggtaccggt?gaaccaggcg?gcccagtcga?cgcggacacc??81540
cgcgacgtgc?agctgggcga?gaccggtgag?cagggcctcc?tgctcggggc?ggcgggagcg??81600
cagcgccggg?gctgccacgg?cgccggtacc?gccgtcgagc?gtgtcgaggc?tctgccgggc??81660
gagggcggtc?aggaccccgc?cggggccgat?ctccaggaag?gcgtcggctc?ccgcctcggc??81720
gagggtacgg?acgccgtcgg?cgaagcggac?ggtctcgcgg?acgtgccgca?cccagtactc??81780
ggggtcggtg?agctgaccgg?gcgcggcgag?ggcgccggtg?acgttggaga?ccaccgggac??81840
gcgcggctcg?gcgtactcca?gcgagcgggc?gacctcgcgg?aaggcgtcga?gcatcggctc??81900
catcagcgcc?gagtggaagg?cgtggctgac?ggacagacgc?tggatcttcc?gcccttcggt??81960
ctcgaactcg?gcggcgaggg?ccgtcacttc?accttcggga?ccggacacga?cgacggagtc??82020
gggaccgttc?acggcggcca?gggacaagcc?ctcggtcagc?cggggcgtca?cctcggcctc??82080
cgtcgcccgt?acggccacca?tcgccccgcc?cgtggggagt?tcctgcatca?ggcgggcgcg??82140
ggcggcgacc?agccggcagg?cgtcgtcgag?cgagaagacc?cccgccacgt?gcgccgccgc??82200
gatctcaccg?accgaatgcc?ccgccacgaa?ctccggcgag?acaccccacg?actccaccag??82260
ccggaacagc?gccacctcca?ccgcgaacag?cgccggctgc?gtgtacccgg?tcacgtccag??82320
cagcgccgcc?gcctcggagc?cctcctccac?gaacagcacc?tcccgcagcg?aacgctccag??82380
ccccgtgtcc?agacgggcca?ccaccgcgtc?aagcgcctcc?gcgaacaccg?ggaaacgctc??82440
gtacaactcc?cggcccatcc?ccgcacgctg?cgaaccctgg?cccgagaaga?ggagagcgag??82500
tgtgcgctcg?gtggcccgtc?cccgcgcggc?ctcggccggt?tcgccctcgg?ggcccgcgag??82560
gagcaccgca?cggtgttcga?aggtggagcg?tccggtggcc?agggagtgac?cgatgtcgag??82620
cggcgcggcg?ccggtgaccg?aggtgacgcg?ggcgagctgc?gcgtcgagcg?cctcgcgggt??82680
cttcgcggac?accggccagg?ggacgagggt?gggcctggcg?gtgggcgtcc?cgtcctcggg??82740
cgtcgcgggc?tcctcgggct?cgggcgcctg?ctcgatcacg?acgtgggcgt?tggtgccgct??82800
gatgccgaag?gaggagaccc?cggcacggcg?ggggcggccg?gtctcgggcc?aggcggtgtt??82860
ctcggtgagc?aggcggacgt?tgcccgcgcc?ccagtcgacg?tggctggagg?cctcgtcgat??82920
gtggagggag?cggggaagga?cgccgtgctg?gatggcgagc?acggtcttga?tgacgcccgc??82980
gacgccggcg?gcggcctggg?agtgcccgat?gttcgacttc?accgagccga?gcagcaacgg??83040
ccggtcctcg?ggccggtcct?gcccgtacgt?cgccagcagc?gcctgcgcct?cgatcgggtc??83100
gcccagcggg?gtgcccgtcc?cgtgtgcctc?cacggcgtcc?acgtcggcgg?cggagagtcc??83160
ggcgcccgcc?agggcctggc?ggatgacgcg?ctgctgggac?gggccgttgg?gggcggtcag??83220
cccgttggag?gcaccgtcct?ggttgacggc?cgagccgcgc?accacggcca?gtacctggtg??83280
gccgttgcgg?cgggcgtcgg?agagccgttc?caggacgagg?acgccggcgc?cctcggccca??83340
gccggtcccg?tcggcggagt?cggcgaacgc?cttgcagcgg?ccgctggtgg?agatgccgcc??83400
ctggcgggtg?aagcccgaga?agcccatcgg?ggtggacatc?acggtgacgc?cgcccgccag??83460
ggcgaggccg?cactcgccgt?tgcgcagcgc?ctgggccgcc?aggtggatgg?cgaccagcga??83520
ggcggagcag?gcggtgtcga?cggtgacggc?gggcccggcg?aggtcgaagg?cgtacgacag??83580
gcggccggag?accacgctgg?cggtgaggcc?ggtggtggcg?tggccctcgg?cgtcctcccg??83640
ggagttcatg?acgacgccga?cgtagtcgac?gccggccgtg?ccgacgtaga?cgccggtgcg??83700
gctgccgcgc?agggagaccg?ggtcgatgcc?cgccctctcc?accgcctccc?aggtggtctc??83760
cagcaggatc?cgctgctgcg?ggtccatggc?gaccgcctcg?cggggcgaga?tcccgaagaa??83820
gcccgcgtcg?aaggcggcgg?cgtcgacgaa?gccgccctcg?cccgccgcgc?tgctgccggc??83880
gccctcgccg?ttcagggcgt?cgaggtccca?gccccggtcg?gcggggaagg?gcgcgatgcc??83940
gtcacggccc?tcctccagga?gccgccagta?ctcctcgggg?gtcgcgacgc?ctccgggcag??84000
ccggcaggcc?atgccgacga?ccgcgatggg?ttcgcggcgg?tgggcctccg?cctcctccag??84060
ccgccggcgg?gtcttgtgca?gatcggccgt?gacccacttg?aggtagtcga?cgagcttctt??84120
gtcatcgggc?atgacgtggg?gaaccttcct?gtggtggatc?aagctcgtct?cagaggtcgc??84180
ccaggcggcc?gagctcgttg?tcgatgaagg?cgaagacctc?gtcggtgctg?gccgactcga??84240
agtcgtcgtc?gagggaggaa?ccggcctgct?cgggggcgtt?gccgcgcacc?tggtcgagca??84300
tctggcccag?tcgcagggcg?aggcccgcgc?gggtgatctc?gtccgggtcc?ccggccgaca??84360
gcagcgtctc?gaagcggtcg?agttcggcga?ggagcgacgg?tccctgcggg?acggcgtcgt??84420
caccggccag?ctcggcgacg?aagtgttcgg?cgagcgcggt?gggggtcggg?tagtcgaaga??84480
ccagcgtggc?gggcagccgc?agcccggtcg?cggtcgccag?gtggttacgg?agttccagcg??84540
ccgtcagcga?gtcgacgccc?agctcgcgga?actcctggct?gacgtcgacg?gacttcggtg??84600
aggcgtggcc?caggacccgg?gcggcctgtt?cgcggaccag?gtcggtgacg?taccggacgc??84660
gctcggcggc?accgagcccg?gcgagcttgg?cgccgagcgc?ggccgaagcg?ccggccgcgt??84720
ccgtggaggc?ggcggtacgg?cggccgctgc?ggaccatgga?gcggaacagc?gggggcaggt??84780
cctccggcgc?cgcgcccctc?atcgctccgg?cggcgagacc?gaccaggacg?aggaaggact??84840
cgtccgagcc?ccgggcgatg?tcgaacagtt?ccaggccctg?gtcgacggcg?agcggcggga??84900
gtccgccgga?ctgcatgcgg?cgcatgtccg?tgtcggacag?ggtgctggtc?atgccgccgt??84960
cgtgggccca?ggggccccag?gccagcgagg?tgccggccag?gccgaggtgg?cgccggtgcc??85020
gggtgagggc?gtccaggaag?gagttggccg?cggcgtagtt?gccctggccg?gggctgccca??85080
tgacgcccgc?gacggacgag?aagggcagga?aggcggcgag?gtcgaggtcg?cgggtcagct??85140
cgtgcaggtg?ccaggcggcg?tccaccttgg?gccgcaggac?ggcggcgagg?cgttcgggcg??85200
tgagggaggc?gatcaccccg?tcgtcgagga?tgcccgcggt?gtgcacgacg?gcggtgagcg??85260
ggtgtgcggc?cgggaccgcg?tcgaggagcg?cggccgtggc?ctcgcggtcg?gcggtgtcgc??85320
aggcggcgac?ggtgacctcg?gcgcccagtt?cccgcagctc?ggcggcgagt?tcggcggcgc??85380
cgggggcgtc?cgcgccgcgc?cggctggtca?gcagcaggtg?gcgcatgccg?gcccgggcga??85440
agcggcgggc?gaggtggccg?ccgagtgcgc?cggtgccgcc?ggtgatgagg?acggtgccct??85500
cggggttcca?gcggggcggc?atggtcagca?cgatcttgcc?ggtgtgcttg?gcctggctca??85560
tgaagcggaa?cgcctcgcgg?gcccgccgga?cgtcccaggt?gcgcaccggg?agcggccgca??85620
gcgcgccctc?ggcgaagagg?tcgaggagtt?cgccgaggag?ggccttgttc?cgctccggtc??85680
cggcctcgcc?gaggtcgaag?gcctggtagc?ggacctcgcc?cgtggtctgc?gggtcgcgga??85740
tgtcggtctt?gcccatctcc?aggaaccggc?caccgggagc?cgtgatccgc?aacgacgcgt??85800
ccacgaagtc?accggcgagc?gcgttcagga?ccacgtccat?ccccgcgcca?ccggtgacct??85860
cccggaactt?ctcctcgaag?cccaggtcac?gcgaggacgc?gatgtgagcg?tcgtcgagcc??85920
ccagactccg?cagcgtctcc?cacttgggct?cgctcgccgt?ggcgaagacc?tcggcgccca??85980
cgtgccgcgc?gagctggatc?gccgccatac?cgacaccacc?cgcaccggcg?tggatcagca??86040
cccgctcccc?cgcctggacc?gaggccaggt?cacggaaggc?gtacagggcg?gtgaggaaga??86100
ccagcggcac?cgaggccgcg?tcccgcatgg?tccagccttc?ggggacctgg?gtgacgtagt??86160
gctggtcggc?gacgacgacg?gggccgaatc?cgccgggcac?ggtgccgagg?acgcggtcgc??86220
cgggggcgag?gccggtgacg?gcctcgccga?cggcggtgac?cacgccggcg?gcctcggtgc??86280
ccatggggcc?ggactcgccc?gggtacatgc?cgagcgcgtt?cagcacgtcg?cggaagttga??86340
ggccggccgc?ctcgacgtcg?atgcggacct?cgtgggcgcc?gagtggctgg?aggacctccg??86400
ggcacggggc?gaggaccagg?ttgtccaggc?tgcccttgcc?ggtggtgtcc?aggcgccacg??86460
gggtgccggt?gggggcgagg?aggccgggtg?ccgtggtgag?ccgttcgagc?cggccgacca??86520
gcgcggtgcc?ctcgcggacg?gcgaactggg?cgtcgccgct?gcccagcagc?cccggcaggt??86580
cgggcaggag?cgcgcgcagg?gtgtccgggg?cgtccgctcc?gtcgaggtcc?agcaggacga??86640
agcggtccgg?gttctcggac?tgggcggagc?gcaccaggcc?ccaggcggca?ccggccgcga??86700
ggtcgcggac?ggtctcggtg?tcgtgggcgg?cgaccgctcc?cgtggtgacg?aagaccaggc??86760
gggagtggcc?gagccgctcg?gcggcctgcc?actgctggag?caggtcgagc?gtccgcgtgg??86820
tcagcgcgtg?gacggccgcc?ggcacgtcgg?cgccgtgggc?gtccgggtcc?ccggcccccg??86880
ccgcgtcacc?ggcaccggcg?agcgggacga?ggacgaagtc?gggtgctgcg?gacgggtcgg??86940
cgtcggggcc?ggtcagctcg?gtgagggagg?ccagggcggt?gcccacgccg?aagacgtcct??87000
cgccgagggt?cgccgcggtc?aggccctcgg?tgggcttgac?cgcgggtgcg?gccgtccagt??87060
ccaggcggaa?gaccggctcc?tggccaccgg?tggcgaccgg?ggcgctgggc?accgtggggg??87120
cgcgcaggac?cagggactcg?gcgcagagca?ccgggacgcc?ctccgcgtcg?acggcggtca??87180
gccggaccga?ctcgtccccg?agccgggtga?tccgcacccg?cagcgtggtg?gcgcccctgg??87240
cgtgcaggga?gacgccgttc?caggcgaagg?gcagcagcgg?gttctcctcg?ctgcccaccc??87300
cgaggtagcc?gttggcgtgc?tggacggcgt?ccaggagcgc?ggggtgcatg?ccgaagtact??87360
gggcgtcccc?ggcgacctcc?tcggggaggg?cgacctccac?gaaggcctcc?tcaccgcgga??87420
gccacacctg?gcgcaggccc?tggaaggacg?gcccgtaccc?ggtacggctg?tagtcgccgt??87480
cgaactccac?ggagaccgcg?tccgccgggg?gccagacggg?ggcttcgaag?gagtcggtgc??87540
gctcctgaac?ggccaggaac?ccgtcggcgt?gccgggacca?cggcgcgtcg?acggcgtcgg??87600
agggacggga?gtagaaggtg?accggcctgg?tgccggtgtc?gtcgggagcg?ccgacgacga??87660
cctggacgga?gaccgggtgc?ttctcgtcga?ggaccatcgg?cgcggcgagg?acgagttcct??87720
cgacgcgggc?gcagccgacc?tggtcggctg?cgcggatggc?catctccagg?tagccggtgc??87780
ccggcatgat?gacggtgccg?ccgacacggt?ggtcgaggag?ccaggggtgg?acctgcatgg??87840
agatctggct?ggtgaacagg?acgccctcgg?agtcggcgag?cgggacggcc?gcgccgagca??87900
gggggtgttc?ggcggagatg?aggccggccg?tgctgatgtc?gccggtgagg?gcggccgggc??87960
gcggccagta?ccgctcgcgc?tggaaggcgt?aggtgggcag?ctcggtgcgg?cgggcgccgg??88020
tgccggtgaa?ccaggcggac?cagtccaccc?ggacgccgct?gacgtggagc?ccggcgaccg??88080
cggtcagcag?cgcggtctcc?tcgtcgcggt?ccttgcgcag?ggccgggagg?acgaccgcct??88140
cgtcccggtc?gtcggcttcg?aggacgctct?gggccagggc?ggtcaggaca?ccgccgggtc??88200
cgatctccag?gaaggcgttg?gcgccggcgc?cggccagggc?gcggacaccg?tcggcgaagc??88260
ggacggtggc?gcggacgtgc?tcgacccagt?acgcggcccg?ggtgagctgt?ccgggttcgg??88320
cgagggcgcc?ggtgacgtcg?gagaccaccg?ggatacgcgg?ctccgcgtac?tccaggctct??88380
ccgccacctg?ccggaacgcg?tcgagcatcg?gctccatgag?cggggagtgg?aaggcgtggc??88440
tgaccggcag?gcgctgcgtc?ttgcggccct?cggccgcgaa?cgcctccgcc?agggcgaggg??88500
cttcgtcctc?ggtgccggcg?atcaccacgg?agtcggggcc?gttcacggcc?gccagggaca??88560
ggccctcggt?gagccggggc?acgacctcgg?cctcggtcgc?ccgcacggcc?accatcgccc??88620
cgcccgaggg?cagttcctgc?atcagacggg?cacgggcggc?gaccagccgg?caggcgtcct??88680
ccagcgagaa?gactcccgcc?acgtgcgccg?ccgcgatctc?gccgaccgag?tggcccgcga??88740
cgtggccggg?gcgcacgccc?cacgactcga?cgaggcggta?cagggcgacc?tcgacggcga??88800
acagcgcggg?ctgcgtgtac?ccggtcgtgt?ccaggagtgc?cgccgtcccg?gagccctcct??88860
ccgcgaacag?cacctcccgc?agcgaggggg?tcaggccggt?gtccagccgg?gcgaggacgg??88920
cgtccagcgc?ctcggcgaag?accgggaaac?ggtcgtacag?ttcgcggccc?atgccggcac??88980
gctgcgatcc?ctggccggag?aagagcaggg?cgagcgagcg?caccgcggcc?cggccccggg??89040
cggcctccca?cggcgtcgtg?ccggggcgcg?cgaggagcac?ggcgcggtgg?tcgaagcggg??89100
cgcggccggt?ggccagggag?tggccgacgt?cgagcggggc?cgcgccgtcc?agggcggtga??89160
cggccgcgat?ctgcccgtcg?agggcctcct?cggacttggc?cgacaccggc?cacgggacga??89220
cggtgggtgt?gggccccggc?aggagggccg?caccgggctc?ggcgggctcc?ggggccgggg??89280
cctgctcgat?gatggtgtgc?gcgttggtgc?cgctgatgcc?gaaggacgag?atgcccgccc??89340
gccagggccg?gccgctgtcg?ggccaggccg?actcctccgt?gagcagccgt?atcgccccgg??89400
actcccagtc?gacgtgggtc?gagggccggt?cgacgtggag?ggtgcgcggc?aggacgccgt??89460
ggcgcatcgc?catgacggtc?ttgatgatgc?cggcgacgcc?ggcggcggcc?tgggtgtggc??89520
cgatgttcga?cttgatggag?ccgagcagca?gtggccggtc?cgcgggccgg?tcctgcccgt??89580
acgtcgccag?cagggcctgg?gcctcgatcg?ggtcgcccag?cggggtgccc?gtgccgtggc??89640
cctcgaccgc?gtcgatgtcg?gagggggtca?ggccgccgcc?ggccagcgcc?tggcggatga??89700
cgcgctgctg?ggaggggccg?ttgggggcgg?tgaggccgtt?ggaggcgccg?tcctggttga??89760
tggccgagcc?gcgcacgacg?gcgaggacct?cgtgaccgtt?gcggcgggcg?tcggagagcc??89820
gctcgacgac?gatcaggccg?accccctccg?accagccggt?gccgtccgcc?gcgtccgcgt??89880
acgccttgca?gcggccgtcg?acggccaggc?cgttctggag?ggtgaagccg?gagaaggcgg??89940
acggggtgct?catcatggtg?atgccgcccg?ccacggcgag?gtcgcactca?cccgcgcgca??90000
gcgcctgcat?cgcccagtgg?agggcgacca?gtgaggagga?gcaggcggtg?tcgacggtga??90060
ccgccgggcc?ttccaggccg?aaggtgtagg?ccagccggcc?cgagacgacg?ctggcggcga??90120
ggcccgttcc?ggcgtggccc?tccaggtcct?cgcgggagtt?catgacgagc?gtggagtagt??90180
cctggccgtt?ggtgccgacg?aagacaccgg?tacggctgcc?gcgcagttgg?tcggcgtcga??90240
tgccggaccg?ttcgaacgcc?tcccaggtgg?tctccaggag?caggcgctgc?tgcgggtcca??90300
tcgccagcgc?ctcacgcggg?gagatgccga?agaaggccgc?gtcgaagtcg?gctgccccgg??90360
agaggaatcc?gccgcgcagc?gtggcgctgc?ggccccggcc?gtcggccccg?ccggtcgtca??90420
gggtggcgag?gtcccagcct?cggtcctcgg?ggaatgcctc?gatgccgtcg?cggccctcgc??90480
tgaccatggc?ccacaggtcc?tgcggggagc?ggaccccgcc?gggcaggcgg?caggccatgc??90540
cgacgatgac?gaccgggtcc?tcggccagtg?ccgccggggt?ggcccggccg?gagcccgggg??90600
tgtcctgctc?gcccagcagt?tcggcgagga?ggtgttcggc?gagggcctgg?gcggtcgggt??90660
agtcgtagac?ggtggtggcg?ggcaggcgca?ggccggtcgc?gagggcgatc?cggttgggca??90720
gctcgatggc?ggtgagcgag?tcgaagccca?ggtcgcggaa?gttccggtcg?gcggcgacgg??90780
cctccggtcc?tgggtggccg?aggacggctg?ccgcgtgggt?gcgcaccagt?tccgtgacgc??90840
tgtcggtgcg?ttcgtcggcg?gggaggccgc?gcagccgctc?ggcgagtccg?gaggcggccg??90900
tgcgggcacg?gtcgcgggtg?gtctcggcgt?cggcgagggc?ctgccgggcg?tcgggcaggt??90960
cgcgcaggag?cgcgttgccg?cgcatgccga?tcaggccgtc?caggacctgc?ggctggcgcg??91020
ggtcgaacag?gacgggtgcg?gcctcgggcc?gggtcacggc?ctgccgcagt?gcggccaggg??91080
ccagatccgg?gtggaccgcc?gggtgcccgg?ctcctgccct?cggggcggcg?ggggcgtcgt??91140
cccctccggt?ctcgtcggcg?tccccgatcc?aggcgcccca?ggccatcgag?gtggcgggca??91200
gcccctcact?ccggcggctc?cgggcgaggg?cgtcgagtac?ggcggtggcg?gcggcgaggt??91260
tggcccggcc?cgccgtgccg?acggtcccgg?cgacggagga?gcagagggcg?aagacgtcga??91320
ggtcaaggcc?gcgggtcagc?tcgtccaggt?ggagggcggg?cgcggtccgc?gcgtggtgcg??91380
gagcggcgaa?tcgttccggg?gtcaggtcgt?cgaggactcc?gtcgtcgacg?actgcggcgg??91440
cgtggacgac?ggcggagagc?ggggtgtcgg?cggggatgcc?gtcgaggacg?gccgcgaggg??91500
cgtcccggtc?ggcggcgtcg?caggcgacga?gggtgacgcg?ggcaccggcc?gcctccagtt??91560
cggcgcggag?cgcgtcggcg?ccgggggcgt?cgggaccgcg?tcggccgagg?agcaccaggt??91620
gcgcggcgcc?ggctccggcg?agccagcgcg?cgacgtgggc?gccgcgtccg?ccggtgccgc??91680
cggtgacgag?gacggttccg?cggggctgcc?agccgtcgcc?gggctccgcg?gccggtgccg??91740
ggacgagccg?gcgtgcgaag?gcggcggagg?agcggacggc?cacctggtcc?tcgccgtcat??91800
gtccggcgag?gacggcggcg?aagcggcggg?cggcgcgttc?gtcccacgcg?gagggcaggt??91860
cgacgagccc?gccccacacg?gcggggtgtt?cgagggcggc?gacccggccc?aggccccaga??91920
cggcggcctg?ggcgggggcg?gtgacggcct?cggaacccgc?caccgcgacg?gctccccggg??91980
tcaggcacca?caggggggcg?tcgaccccgg?cgtcgagcag?ggcctggaac?aggacggcgg??92040
tcggggcggc?gggggctccc?gccgggtcgc?cggagacggc?tgcctccggc?gtgtcggcga??92100
gggccagcag?ggagaccaca?ccggcgaggg?cggcgccgtc?ggcggagagg?gcgcgcaggc??92160
ggtcggcgag?cgcgtggcgc?tcgacggtgt?ccacggtgag?gcggacgacg?tcggtgccga??92220
cggcgtcgag?gacggcggcg?gtccaggggt?cctcgccgta?cgcggcgggc?acgacggcca??92280
gccaggttcc?ggccggggcg?ggcgcaccgg?gcggcagcga?cagcggcttc?cacgtctcgt??92340
ggtggcggtt?ggagtcgacc?atggcctggt?cccggcgccg?gcgccgccag?gtggagaggg??92400
ccgggagtac?cgcgccgagc?gcctcggtgt?ccacggccag?gtcggtggcg?agacgggtca??92460
ggtcctcgcc?ctcgacggcg?gtccagaagg?cgccgtcgag?cgggtcggag?gagccgccgc??92520
ccgtaccggg?gcgccgggtg?tcgggccagt?ggcggacgcg?ctggaaggcg?taggtgggca??92580
ggtcgacgcg?gcgggcgccg?gtgccctcga?agcaggcggc?ccagtcgacg?gggacgccgg??92640
tgacgtggag?cgtggcgagc?gcggtgagca?gggcgggctc?ctcggcccgg?tccttgcgca??92700
gcgcgggcgc?ggtgacggcc?tcggagtcgg?tgcccagggt?ctgccgggcg?agggcggtga??92760
ggacgccgcc?ggggccggcc?tccaggtagg?cgtcggctcc?cgcctcggcg?agggcgcgga??92820
cgccgtcggc?gaagcggacg?gtctcacgga?cgtgccgcac?ccagtactcg?gggtcggtga??92880
gctgaccggg?cgcggcgagg?gcgccggtga?cgttggagac?gacggggaga?cgcggttcgg??92940
cgtacgccag?cgagcgggcg?acctcgcgga?acgcgtcgag?catcggctcc?gtgagcgcgg??93000
agtggaaggc?gtggctgacc?tgcaggcgct?gggtcttgcg?tccctcggcc?acgaactcgg??93060
cggccagcgc?ggtcacttcg?ctctccgggc?cggacacgac?cacggagtcc?gggccgttga??93120
ccgcggcgag?ggagagtccc?tcggtcagcc?gtggggcgat?ctccgcctcg?gtggcctgca??93180
cggccgccat?ggcgccgccg?gcgggcagtt?cctgcatcag?gcgggcgcgg?gcggcgacca??93240
gccggcaggc?gtcctccagg?gagaagaccc?cggccacgtg?cgcggcggcg?atctcgccga??93300
cggagtgacc?ggccacgtac?tccggcgaca?cgccctgcga?ctccagcagg?cggtgcaggg??93360
ccacctccac?ggcgaagagc?gcgggctggg?tgtagccggt?ggtgtccagg?agagcggccg??93420
tctcggagcc?ctcctccgcg?aagagcacct?cacgcagcgg?acggtccagc?tccgggtcga??93480
gcagggcggt?gatctcgtcg?agtgccttcg?cgaacaccgg?gtaacgctcg?tacagttcac??93540
ggcccattcc?ggcccgctgg?gaaccctggc?ccgggaacag?caccgcgagc?ctgcgctcca??93600
cggcacggcc?ccgcgccacc?tccaccggct?cgtcctcggc?accggtgccc?gccagcagga??93660
ccgcgcggta?ctcgaaggag?gcgcggccgg?tggccaggga?gtggccgatg?tcgagcgggg??93720
tggcgccggt?gacggtggcg?atccgggcga?gctgtgcgtc?gagcgcctcc?ggggacttcg??93780
cggagaccgg?ccaggggacg?gccgccggag?ccggggcgga?cgcggcggcc?ggcgtggcct??93840
ccacgatctc?cggggcctgc?tcgatgatgg?tgtgcgcgtt?ggtgccgctg?atgccgaagg??93900
aggagacggc?ggcgcggcgt?ggacggccgg?tctcgggcca?ctccgtggtc?tcggtcagca??93960
ggcggacgtc?gccctcggtc?cagtccacgt?gcgtggaggg?ccggtcgatg?tggagcgagc??94020
ggggcaggac?accgtgccgg?atcgccatga?cggtcttgat?gaccccggcg?acaccggcgg??94080
cggcctgcgc?gtggccgatg?ttcgacttga?tggagccgag?cagcagcggc?cggtcgccgg??94140
gccggtcctg?cccatacgtc?gccagcagcg?cctgggcctc?gatcgggtca?cccagggtgg??94200
taccggtgcc?gtgtgcctcc?acggcgtcga?cctcgtcggt?cgagagcccg?gcgctcgcga??94260
gggcctgacg?gatgacccgc?tgctgcgagg?gtccgttggg?cgcggtcagg?ccgttggagg??94320
cgccgtcctg?gttgacggcg?gagccgcgca?gtaccgcgag?gaccgggtgg?ccgttgcggc??94380
gggcgtcgga?gaggcgctcg?acgacgagca?tgcccacgcc?ctcggaccag?ccggtgccgt??94440
ccgccgcgtc?cgcgaacgcc?ttgcagcggc?cgtcggtggc?caggccgccc?tgccgggtga??94500
agcccgcgta?ccccatggcg?gtggacatga?cggtgacgcc?gccggcgagc?gccaggtcgg??94560
cttcgccgga?gcgcagcgcg?tgcgcggccc?agtggagggc?gacgagcgag?gaggagcagg??94620
cggtgtcgat?ggtgaccgcc?gggccctcca?gtccgaaggt?gtaggacagc?cggccggaga??94680
tgacactggt?ggcgaggccg?gtgggggcgt?ggccctcggc?gtcctgacgg?gagttcatga??94740
ccagggtggt?gtagtcctgg?ccactggtgc?cgacgaaaac?accggtacgg?ctgccgcgca??94800
cctcggtggg?ggtgatgccg?gcgcgctcga?acgcctccca?ggtggtctcc?aggagcaggc??94860
gctgctgggg?gtccatcgcc?agcgcctcgc?gcggggagat?gccgaagaag?ccggcgtcga??94920
agtcggcgac?gtcgtagagg?aatccgcctt?cggaggtggc?gctgcggccg?tggccgctct??94980
cgccgccgcg?ctggagggtg?tcgaggtccc?agccccggtc?ggtcgggaag?gcggagatgc??95040
cctcctggcc?gtcgaggacg?agctgccaca?gctcctcggg?agagctgacg?ccgcccggca??95100
tccggcaggc?catgccgacg?atgacgacgg?ggtcctcggc?gagggccgcg?gcgacgggcg??95160
tcggggcggt?ggcgccagtg?gcgcgctgct?cgtcgagcag?ggcggcgatc?aggtgctccg??95220
ccagcacgcc?gggcgtgggg?tggtcgaaga?cgagggtggc?gggcagccgc?aggccggtgg??95280
cgccggtgag?gcggttgcgc?agttcgacgg?cggtgaggga?gtcgaagccc?aggtcgtgga??95340
agtcgcgttc?ggcgtcgatg?gcctgggcgg?aggagtggcc?gaggaccgag?gcggcctcgg??95400
cccggatcag?gttcacggcg?aagcggagcc?gctcgtcctc?gcgcaggtcg?aggaggcgcc??95460
gggtgagctc?gtcggcggta?cccgcgccgc?cgacggcggt?cgcggcggcg?cgccgggtgc??95520
cgcggaccag?gttgcgcagc?agcggcggca?cctccccggg?catccgggtg?gagcccgagg??95580
ctccgagggg?gacgaggtgc?ggctcgtcgg?agacgacggc?ggcgtcgagg?agggcgagcc??95640
cctgctcgac?ggtgagggcg?ggggccgccg?acgccgacat?gcgccgcacg?cccgcgtcgg??95700
tgagggtgcc?ggtcatgccg?ctggtctgtt?cccaggcccc?ccaggccagg?gagagcccgg??95760
ccagaccctc?ggcccggcgg?tactgcgcca?acgcgtccat?gaacacattg?gcggcggcat??95820
agttgccctg?ccccgcactg?cccatcacac?cggacacgga?cgagaacatc?acgaaccctg??95880
cgagacccat?gtcccgcgtc?aactcgtgca?ggtgccacgc?agcgtccacc?ttcggacgca??95940
acacccccga?caaccgctcc?ggcgacaacc?ccgtcaccac?accgtcgtcc?agcacacccg??96000
ccgtatgcac?cacagccgtc?aacggatgcc?ccaccggcac?cgacgccaac?agccccgcca??96060
cggcagcacg?gtccgccaca?tcacacgcca?ccacgtccac?gtgggcaccc?agcccggcca??96120
actcctcacg?gaaagcgtcc?acaccctccg?ccgccggacc?acgccgcgac?accagcagca??96180
gacgccgcac?cccacgcgcc?gacaccagat?gacgcgccac?ctcacgcccc?agaccacccg??96240
tcccaccagt?gaccaggacc?gtgccctcgg?ggttccagcg?cggcggcatc?gtcagcacga??96300
tcttgcccac?atgcctcgcc?tggctcatga?aacggaacgc?ctcacgcgcc?cgacgcacat??96360
cccacgcacg?caccggcaac?gggcgcaacg?ccccctccgc?gaacaggccg?aggagttcgc??96420
tcagcatctc?gccggtccgg?tccggtcccg?cctcgccgag?gtcgaaggcg?cggtaccgca??96480
cgtcaccgac?cgcgtgcggg?tcgcggatgt?cggtcttgcc?catctccagg?aaccggccgc??96540
cggaagccgt?gatccgcaac?gacgcgtcca?cgaagtcacc?ggcgagcgcg?ttcaggacca??96600
cgtccatgcc?cgcgccacca?gtctcctccc?ggaacttctc?ctcgaagccc?aggtcacgcg??96660
aggacgcgat?gtgagcgtcg?tccagcccca?gaccccgcag?cgtctcccac?ttgggctcac??96720
tcgccgtcgc?gaagacctcg?gcacccatgt?gccgcgcgag?ctggatcgcc?gccataccga??96780
cgccacccgc?accggcgtgg?atcagcaccc?gctcccccgc?cgacaggccg?gcgagttcgg??96840
tgagcgcgta?gtaggcggtg?aggaagacca?ggggcaccga?ggcggcgtcc?tcgtcgctcc??96900
actcctcggg?tacgcgggtg?aggaagcgtt?cgtcgatcag?ggtctccgtg?gcgaggccgc??96960
cggggaccat?gcccatgacg?cggtcgccga?cggagagccc?ggtgacctcg?gggcccacgg??97020
cggtgacgaa?cccggccgct?tccgcgccga?gcagtccggc?ctcgccgggg?tacatgccga??97080
gcgcgttcag?cacgtcacgg?aagttcaggc?cggcggctcg?tacctcgacc?cggacctggc??97140
gctcctgagg?ctccgccagc?tcctcggggc?aggggcgcag?ggtgagcgcg?tccaggctgc??97200
cgcgtgacgg?ggagtccagg?cgccaggggc?cgtcggcggg?cggcaggagg?gacggggcgg??97260
tcacggcccg?gtcgagacgg?ccgaccagga?cggcgccctc?gcggacgacg?aactgggcgt??97320
ctccgcccga?gagcggaccg?aggagttgcg?gcagagcggt?ctcgacgggg?gtggtgtcgt??97380
ccaggtcgag?gagggcgaac?cgggtggggt?tctccgactg?ggcggcgcgg?acgaggcccc??97440
agacggcggc?ggcggggagg?tcgtcgaccc?gctcgccggg?gcgggcacag?accgcgcccc??97500
gggtgacgaa?gacgaggcgg?gtgtcggcga?accgttcgtc?ggccagccac?tcctgcgcca??97560
gggcgagggc?ctgtgcggcg?cgctcgtggg?tggcggcggg?cacgtcggca?ccctcggccg??97620
gtgcggggac?ctcgaccagg?acgaggtcct?cctcgccggt?cagcggggcg?agggtggccg??97680
cggccccgcc?ggtgccgagg?gcaccggcgg?tcgtgtgacg?ggcggcgggg?gcgtcgccgg??97740
tctcggggcc?ggcggtccac?tccaggcgga?gcagcgagtc?gagttcggtg?cggcgggcgg??97800
ccggggcgtg?gtccccggcg?ggaacacgca?gcaccagcga?ctcggcggag?agcaccgggg??97860
cgccctcgac?gtccacggcg?gcgatggaga?cggagtcctc?gccggtccgg?gcgacgcgga??97920
agcggaccac?ggaggcgccg?ccggcgtgca?gggagactcc?ggcccacagg?aacgggagca??97980
gctggtgctc?gtcgtcgagc?ccggcgaagc?cgacggactg?gacggcggcg?tcgagcagcg??98040
cggggtgcat?cccgtagtac?tcggcgtcgt?cggcctgcgg?gggcagggcc?gcctcgacga??98100
acgcctcgtc?gccgcgcttc?cagacggcgc?ggatggtgcg?gaagaccggg?ccgtactcgg??98160
tgcggtcgta?gaagtcctcc?aggccgacgg?cgaccgcgcc?cttggggggc?catatctcgg??98220
cgacggcggg?gagggtgacg?gcgccgctgg?tcaggacgcc?ggtcgcgtgc?tgtgtccagg??98280
tggcgtccgg?aacgtcggcg?gaccgggagt?acaggctgac?cgtgcgggcg?ccgctctcgt??98340
cgggggcgcc?ggcccagacc?tggacgacca?cggcggtgtc?cgcgggcagc?agcagcgggg??98400
tggcgagggt?gaattcctcg?acgcggtcgc?agccgacctc?gtcggcggcg?cgtacggcca??98460
gttccaggaa?gccggtggcg?gggaagagca?ccatgccccc?gccgacggtg?tggtcggcga??98520
gccaggggtg?cgtggtgagg?gagaggcgtc?cggtgaagag?gacgccttcg?gaggcggcga??98580
ggccggtggc?ggcgcccagc?agcgggtgcg?cggcggggct?cagaccggcg?ccggtgacgt??98640
ccccgccgtg?tgcggagggg?cgcggccagt?accgctcgtg?ctggaaggcg?taggtgggca??98700
gctcgacgcg?gcgggcgccg?gtgccctcga?agcagccggc?ccagtcgacg?gggacgccgg??98760
tgacgtggag?cgtggcgagc?gcggtgagca?gggcgggctc?ctcggcccgg?tccttgcgca??98820
gcgcgggcgc?ggtcacgctg?tcgctcgcgg?tgccggcggc?gtcgagggtc?tgctgggcga??98880
ggacggtgag?gacgccgccg?gggccgatct?ccagataggc?gttggcgccg?gcctggtcga??98940
gggcgtggac?ggcgtcggcg?aagcggacgg?tagagcggac?gtgctcgacc?cagtactcgg??99000
gcctgctgag?ctgcccgggc?tcggcgaggg?tgccggtcac?gtcggagacg?acagggatgc??99060
gcggttcgcc?gtaccccagg?cccttggcca?cgtcgtggaa?ggcgtcgagc?atcggctcca??99120
tgagcgccga?gtggaaggcg?tggctgaccg?ccaggcgctg?gaccttgcgt?ccttcggcgg??99180
cgaactccga?cgccagcgcg?tcgacctcgt?ggtccggacc?ggcgatcacc?acggagtccg??99240
ggccgttgac?cgcagccagg?gacaggcccc?cggtcagtcg?gcctgcggtc?tccgcctcgg??99300
tcgcctggac?ggccaccatg?gcgccgccgg?cgggcagttc?ctgcatcagg?cgggcgcggg??99360
cggcgaccag?cgtgcacgcg?tcctccaggg?agaggacgcc?cgcgatgtgg?gcggcggaga??99420
tctcgccgac?ggagtggccc?gcgacgaact?ccgggacgac?cccgaaggac?tcgaccaggc??99480
ggtagagggc?gacctccacg?gcgaagagcg?cgggctgcgt?gtagccggtg?gtgtccagga??99540
gagcggccgt?ctcggagccc?tcctccgcga?agagcacctc?gcgcagcgga?cggtccagct??99600
tcgggtcgag?cagggccagg?acttcgtcca?gcgccttcgt?gaacaccggg?aaacggccgt??99660
acagttcccg?gcccatcccg?gcgcgctgcg?aaccctggcc?ggagaacagc?accgcgagcc??99720
tgcgctcgac?ggcgcggccc?cgcgccacct?ccaccggctc?gtcctcaccg?tcggcgcccg??99780
ccagcaggac?cacccggtgg?tcgaaggagg?cgcggccggt?ggccagggag?tgaccgatgt??99840
ccaggggtgc?ggcgtcgagt?gcggtgatcc?gggcgagctg?gccgggcagt?gcctcctcgg??99900
tacgggcgga?gacgggccac?ggcacgaccc?gcgcgagcgc?ctcgggctcc?gcctggggct??99960
cgggggactc?cgtgtcggcg?gtctccggct?ccggctgttc?gaggatcacg?tgggcgttgg?100020
tgccgctgag?cccgaaggag?gagactccgg?cgcgccaggg?gcggccggtc?tcgggccagc?100080
cggtcgtctc?ggtgaggagc?cggaccgctc?cggcctccca?gtcgacgtgg?gtggagggct?100140
ggtcgatgtg?gagggaccgc?ggcagggcgc?cgtggcgcat?ggcgagcacc?atcttgatca?100200
cgcccgcgac?gccggcggcg?gcctgggtgt?ggccgatgtt?cgacttgatg?gagccgagca?100260
gcagcggccg?gtcctcgggc?cggtcctgcc?cgtacgtcgc?cagcagcgcc?tgggcctcga?100320
tcgggtcacc?cagggtggta?ccggtgccgt?gtgcctccac?ggcgtcgacc?tcgtcggcgg?100380
agagcccggc?cgtcgccagc?gcctggcgga?tgacccgctg?ctgggacggg?ccgttgggcg?100440
cggtcaggcc?gttggaggca?ccgtcctggt?tgatggccga?gccgcgcacg?acggcgagga?100500
cgtcgtggcc?gttgcggcgg?gcgtcggaga?ggcgctccag?gacgagcatg?cccacgccct?100560
cggaccagcc?ggtcccgtcg?gcggcgtcgg?cgaacgcctt?gcacaggccg?tcgccggcca?100620
gcccgccctg?acgggtgaac?ccgaagaagt?tcatgggcgt?cgacagcacg?gtcaccccgc?100680
ccgcgagggc?gagagagctc?tccccgctgc?gcagggactg?ggcggcgaga?tggagcgcga?100740
cgagggagga?ggagcaggcg?gtgtcgacgg?tgagggcggg?gccctccagt?ccgagcgcgt?100800
aggagacgcg?gccggagatg?acactggtgg?cgaggcccgt?actggcgtgt?ccctcgacgt?100860
cctcgcggga?ggtcatgacg?aggttggcgt?agtcctggcc?ggtggtgccg?acgaagatgc?100920
cggtggcgct?ggagcgcagg?cccgtcgggt?cgatgccgga?ccgctccagg?gcctcccagg?100980
aggtctccag?cagcaggcgc?tgctgcgggt?ccatcgccat?cgcctcacgc?ggggagatgc?101040
cgaagaaccc?cgcgtcgaac?ccgcccacgt?cgtgcaggaa?gccgccgcgt?cgcgtggcgc?101100
tgacgccgcg?gttgtcgccg?ccaccgccga?agagggcgtc?caggtcccag?ccgcggtcgg?101160
tggggaagcc?ggtgatgcgg?tcctcgccgt?cggcgagcat?gcgccacagg?tcgtcggggg?101220
tctcgatgcc?gccgggcatc?cggcaggcca?tgccgacgat?gacgacgggg?tcgtcggcga?101280
catcggcggc?caccaccggc?gtgccggtct?cgccgtgttc?gtcgaggagt?tcggcgacca?101340
ggtgttcggc?gaggccgtgg?ggggtggggt?agtcgaagac?gagggtggcg?gtgaggcgca?101400
ggccggtgac?ggtggtgagg?cggttgcgca?gttcgacggc?ggtcagggag?tcgaagccca?101460
gctcgcggaa?ctcgcgcccg?ggttccacgg?cccgggccga?ggcgtggccc?agtacggcgg?101520
cggcctcggt?gcggaccagt?tcgacggcgt?gacggacccg?gtcctcggcg?ggcagcgcca?101580
ggaggcggcg?ggcgaggtcg?gccgcggtgc?tcgcgccgcc?ggcggccgtg?gccgcggagc?101640
gacgcgtgcc?gcggacgagg?ttgcgcagca?gcggcgggac?caggccgagg?acgcgctggt?101700
cgcccgacgg?ggcgccgatc?ggtacgacca?ggggctcgtc?ggagccggtg?gcggcgtcga?101760
ggagggctag?cccctgctcg?acggtgagcg?gggcggcccc?ggaggcggtg?acgcgctgca?101820
tgtcggcctc?ggtgagggtg?ccggtcatgc?cgctggtctg?ttcccaggca?ccccaggcca?101880
gggagagccc?ggccagaccc?tcggcccggc?ggtactgcgc?caacgcatcc?atgaacacat?101940
tggcagcggc?atagttcgcc?tgccccgcac?tgcccatcac?accggacacc?gacgagaaca?102000
tcacgaaccc?tgcgagaccc?atgtcccgcg?tcaactcgtg?cagatgccac?gcagcgtcca?102060
ccttcggacg?caacaccccc?gacaaccgct?ccggcgacaa?ccccgtcacc?acaccgtcgt?102120
ccagcacacc?cgccgtatgc?accacagccg?tcaacggatg?ccccaccggc?accgacccca?102180
acagccccgc?cacggcagca?cggtccgcca?catcacacgc?caccacatcc?acgtgggcac?102240
ccagcccggc?caactcctca?cggaaagcgt?ccacaccctc?cgccgccgga?ccacgccgcg?102300
acaccagcaa?cagacgccgc?accccacgcg?ccgacaccag?atgacgcgcc?acctcacgcc?102360
ccagaccacc?cgtcccacca?gtgaccagca?cggtcccctc?gggattccag?cgcggcggca?102420
tcgtcagcac?gatcttgccc?acatgcctcg?cctgactcat?gaaacggaac?gcctcacgcg?102480
cccgacgcac?atcccacgca?cgcaccggaa?gcggctgcaa?cgccccctcc?gcgaacaggc?102540
cgaggagctc?ggtcagcatc?tcgccgatac?gctcgggggc?tgcttcgccg?aggtcgaagg?102600
cccggtagcg?gacctcgccc?gtggtctgcg?ggtcgcggat?gtcggtcttg?cccatctcca?102660
ggaaccggcc?accgggagcc?gtgatccgca?acgacgcgtc?cacaaagtca?cccgcgagcg?102720
cgttcaggac?cacgtccatc?cccgcgccac?cggtcacctc?ccggaacttc?tcctcgaagc?102780
ccaggtcacg?cgaggacgca?atgtgagcgt?cgtccagccc?cagaccccgc?agcgtctccc?102840
acttgggctc?actcgccgtc?gcgaagacct?cggcacccat?gtgccgtgcc?agctggatcg?102900
ccgccatacc?gacaccaccc?gcaccggcgt?ggatcagcac?ccgctccccc?gcctggaccg?102960
aggccaggtc?acggaaggcg?tacagggcgg?tgaggaagac?cagcggcacc?gaggccgcgt?103020
cctcgtcgct?ccactcctcg?ggcacgcggg?tcacgtaccg?ctcgtcgacg?aggacggtgt?103080
cggcgaggcc?gccggggatc?atgccggtca?cgcggtcgcc?gacggcgatc?ccggtgacgt?103140
ccgggccgac?ggccgtgacg?aggccgaccg?cctccgagcc?gagcagtccg?gcctcgccgg?103200
ggtacatgcc?gagcgcgttc?agcacgtcac?ggaagttcag?ccccgcagcc?cgcacctcga?103260
cccggacggc?gcggccctcc?ggctcgtcca?gtgcctcggg?tgcggggacg?agggagaggc?103320
cgtcgatgct?gccggggacg?gtggtgtcca?ggcgccacgg?cagccccggg?accggcagta?103380
ggctcgcgcc?ggtggacagc?cgggccaggc?gggccaccag?gacggcctcg?tcgcgtacgg?103440
cgaactgcgt?gtcgccggcc?gccaggaggg?gaggaagctg?cgccaggagt?tcaccggagg?103500
gcgcggcggt?gcccgcgtcg?aggtcgagga?gggcgaagcg?gccggggttc?tcggcctcgg?103560
cgctgcggac?gagtccgtgc?accgcggcgg?cggcgagatc?gctcacgccg?gtgtcggtcc?103620
cggtggcgac?ggcgccccgg?gtgacgaaca?cgagacgtcc?ggcggcggac?gtggccggct?103680
ccagccactc?ctggatcagt?gccagggtgc?gcgcggtggc?cgcgtggacg?gccgtggggg?103740
tgtcgtcctc?gacgccctcc?agcgggacga?ggaccaggtc?gggggcgggc?gtgacggcgg?103800
cggcgtcggc?gagggaggcg?agagggccgg?gccaggcgcg?gtcggtaccg?agggtgacgg?103860
cgcgcacggg?ggcggcgccg?ccctcgggtg?cggccaccca?ctccaggcgc?aggagcccgt?103920
cctgctcact?gctgtgcagg?gtgggggcgc?gcagcgccga?aggggcgcgc?aggatgaggg?103980
agtcggcgga?gagcaccggg?gcgccctcga?cgtccacggc?ggcgatggac?accgtgtcct?104040
caccgacccg?ggcgacccgc?acccgcacca?cggaggcgcc?gcccgcgtgc?agcgagacgc?104100
cggaccagga?gaacggtacg?agcttcttgc?cgtcaccgag?accggcgaag?ccgacggact?104160
ggacggcggc?gtcgagcagc?gcggggtgca?tcccgtagta?ctcggcgtcg?tccacctggg?104220
gcggcagcgc?gacctcgacg?aaggcctcgt?cgtcgcgggt?ccagacggcg?cgcagtccct?104280
ggaagaccgg?gccgtactcg?gtgcgcgcgt?agaagccctc?caggtcggcg?gcgacggcgc?104340
cgcggggcgg?ccagacggtg?gagtcgaagc?cggtgacgcg?ctcgccacgg?gtcagcagac?104400
cggaggcgtg?ctcggtccag?cgctgctcgg?ggtcgtcgac?ggcctgggag?tagacggtga?104460
cgcggcgggc?gccgtcggcg?tcggccgcgc?cgacgtggac?ctggacgacg?gccgccgagt?104520
tctcggtgag?gatgaggggc?ttggcgaggg?tgaggtcctc?gacgcggtcg?cagccgacct?104580
ggtcaccggc?gcggacggcg?agttcgagga?agccggtgcc?ggggaaggcc?accatcccgc?104640
cgaccgtgtg?gtccagcagc?cacgggtggg?tctgcgcgga?gaggcgtccg?gtgaagagga?104700
ccccgtcgct?gccggccagc?gacacggcgg?cgccgagcag?cgggtgttcg?gcggagacca?104760
ggcccgcggc?gctgacgtcc?ccggcggcgg?ccatcaggac?gggccagtag?cgctcgtgct?104820
gccagcggta?ggtgggcagt?tcggtgcggc?gggcaccggt?gccctcgaag?caggcggccc?104880
agtcgatgtc?gacgccggcg?acgtggagcc?gggccagcgc?ggtgagcagg?gcgcgctcct?104940
cggcgcggtc?cttgcgcagg?acggggacgg?cgacgacgtc?gggcccgtcg?aggcactgct?105000
gggcgagggc?ggtgaggatg?ccgtcggggc?ccagttcgac?gaaggtgtcg?gcgccggcgc?105060
cggccagggc?gcggacgccg?tcggcgaagc?ggaccgtgga?gcggacgtgg?tccacccagt?105120
actcggggtc?gcacagcagg?cggtcgtcgg?cgagggcgcc?ggtgacgttg?gagacgaccg?105180
gcaggaccgg?ctcgtggtag?gtgaggctct?cggcgacgcg?gcggaactcc?gcgagcatcg?105240
gctccatcag?cggcgagtgg?aaggcgtggc?tgaccgccag?gcgctgcgtc?ttgcggccct?105300
cggcggcgaa?ctcggcggcc?agcgcgagga?cctgggcctc?ctcgcccgcc?agggtgacgg?105360
agtcggggcc?gttgacggcg?gcgagggcga?cgccctcggt?caggcgcggg?gcggcctcgg?105420
cctcggtggc?ctggacggcg?accatggcgc?cgcccgcggg?cagttcctgc?atgaggcggg?105480
cgcgggcggc?gaccagcgtg?caggcgtcct?ccagcgagaa?cacaccggcg?acgtgggcgg?105540
cggcgatctc?gccgatggag?tgcccggcca?cgaagtccgg?gaccacgccc?caggactcga?105600
cgaggcggtg?gagggcgacc?tccacggcga?agagcgcggg?ctgggtgtag?ccggtggtgt?105660
cgaggagggc?cgcctcgggg?gtgcggcgcc?gggcgaacat?cacctcccgc?agcgggcggt?105720
ccaggcgcgg?gtcgagcagg?gcggtgatct?cgtccagtgc?cttcgcgaac?accgggaagc?105780
gggcgtacag?ttcgcggccc?atctcggcgc?gctgggcgcc?ctggccggag?aacaggacgg?105840
cgagggagcg?ttcggtggcg?cggccgcggg?ccgcctcggc?ggggacgccg?tcgaggccgg?105900
agagcaggac?ggcgcggtgc?tcgaagaggg?agcgcccggt?ggccagggag?tggccgatgt?105960
cgaggggcgt?ggcgtcggtg?agagcggtga?cggcctcgat?ctgcgcgtcc?agggacgcct?106020
cggagcgggc?gtgcacgggc?cacggcacga?cggtcgggac?ggtctcgggc?tccgccgggg?106080
actccggctc?ggcggcgggt?ccggcctgct?cgatcacgac?gtgggcgttg?gtgccgctga?106140
tgccgaagga?ggagacgccg?gcgcggcgcg?ggcggccggt?ctcgggccac?tcgacggcct?106200
cggagagcag?ccggacggcc?ccggagtccc?agtcgacgtg?gcgcgagggg?tggtcggcgt?106260
ggagggagcg?cgggacgacg?ccgtgccgca?tcgccatgat?catcttgatg?acgccggcga?106320
ctcccgcggc?ggcctgcgcg?tggccgatgt?tcgacttgac?ggagccgagc?agcagcggcc?106380
ggtcctcggg?gcggccctgg?ccgtaggtgg?cgagcagggc?ctgggcctcg?atggggtcgc?106440
cgagcggggt?gccggtcccg?tggccctcga?ccgcgtcgac?gtcggcggcg?gtgagtccgg?106500
cggcggccag?cgcctgctgg?atgacgcgct?gctgggaggg?gccgttgggg?gcggtgaagc?106560
cgttggaggc?gccgtcctgg?ttgacggcgg?agccgcgcag?cacggcgagg?accgggtggc?106620
cgttgcggcg?ggcgtcggag?agccgctcca?ggaggaggac?accgaccccc?tccgaccagc?106680
cggtgccgtc?ggcctcgtcg?gcgaacgcct?tgcagcggcc?gtcaccggcc?aggccgccgg?106740
cgcggctgaa?ctccatcagc?gagccggggg?cggacatgac?gttgacgccg?ccggcgaggg?106800
cgaggccgca?ctcccccgcg?cgcagggcgt?gggcggcggc?gtggagggcg?acgagggagg?106860
aggagcaggc?ggtgtcgacg?gtgaccgccg?gcccctccag?gcccagggtg?taggagaggc?106920
ggccggaggt?ggcgctggcg?gcgatgccgg?tgccgatgtc?gccggtcgcg?tcggcgaggg?106980
agcgcaccag?gaggtacgcg?tagtcctggc?cgttggtgcc?gacgaagacg?ccggtgcggc?107040
tgcctcgcag?gctgcgcggg?tcgatgccgg?cgcgctccac?ggcctcccag?gaggtctcca?107100
gcagcagccg?ctgctggggg?tccatggaga?cggcttcgcg?cggggagacg?ccgaagaagg?107160
cggcgtcgaa?gtcggcgacc?ccgtcgagga?agccgccccg?ctggctgacg?gagtggccac?107220
gggcgtcgac?cccggcgtcc?cgcagcgcgt?ccaggtccca?gccccggtcg?gtggggaagc?107280
cgccgacggc?gtcggtgccg?gaggcgacga?ggtgccacag?gtcctcgggg?gaggtgactc?107340
ccccggggta?gcggcagctc?atcgcgacga?cggcgacggg?ctccgaggcg?gcggccgcga?107400
ggtcgcggtt?ctgccggcgc?aggcgttcgg?tctccttgag?cgaggcccgg?agagcttcga?107460
caactttttc?gctgggcgtg?gtcatgatgg?ctccgtcagt?cccgctcttc?gtcagggtta?107520
ccgttgagtg?ccgcctgcac?caggccgtcg?acgtccatgg?cgtcgatcga?cgcgtcgtag?107580
gcgtcgccgg?ccccggaggg?ctcggcctcc?tggtccgtgc?ctgttccggc?cgggtcctgc?107640
ccggcgaggt?ccagcagctg?gtccaggagt?ccgctgtcgc?gcagccggtc?cagggggacc?107700
tgggcgaggg?cggcgcgcac?ggcccgctcc?tcttcgccgg?ctccgtccgt?ggcgggggca?107760
ccgggggtgc?cggccgggag?gagttgtccg?aggatgtggg?cggcgagtgc?ggcgggcgtg?107820
gggtggtcga?acacgagggt?cgcggacagg?gtgagtccgc?tgacggcgcc?gagctggttg?107880
cgcagctcga?cggcgccgag?ggagtcgaat?ccgaggtcgc?ggaaggcccg?gtcggggccc?107940
acctggtcgg?ttccggtgag?gccgaggacc?tccgcggcgc?gttcgcgcac?cagcgtcagg?108000
accgtctggg?tacggcggct?ctcgggcagc?ctggccagcc?ggtcgcgcag?cgagggaccg?108060
gagtccgcgg?cctcgccgcc?ggcggatgcg?gccttcttga?gggcggcgta?cgcgggcatc?108120
tcggccagca?ggctgctggg?ccggacggtg?gtgaacgcgc?ggacgaaccg?gtcggggtcg?108180
acgtcggcga?cgacggcgac?cgggtcgctg?cccgtgacga?cttgccgcag?cgcgaggacc?108240
gcgaggtccg?ggtcgagcgg?ccggatgccg?gtgcggcggg?cgagcgcggc?ggcgcggacg?108300
ccgtcggcca?tgccctcccc?gccccaggcg?ccgtacgcca?cggaggtggc?gggcagcccc?108360
tcggccctgc?gctgttcggc?gagggcgtcg?aggaccgcgt?tggcggcggc?gtaggtgccc?108420
tggcccgggt?tgccgacggc?ggcggacgcc?gaggagaaga?gggcgaacac?ctccaggtcg?108480
tgggcgcggg?tcagttcgtc?caggagcagc?gcggaggcca?ccttggcccg?gaacaccgtg?108540
gcgaaccgct?cgggggtcag?gccgtccacg?acgccgtcgt?ccagcactcc?ggcggtgtgg?108600
atgacgccgg?tgagcggcgc?gtcctcgggg?atcgccgcga?ggacggcggc?cagcgccttc?108660
cggtcggcgg?tgtcgcaggc?ggtgatgacg?ggttcggcgc?cgagcgcgcg?caggtcggcg?108720
gcgagttcgc?cggcgccggg?cgcgtcgggt?ccgctgcggc?tgaggaggac?caggcggcgg?108780
gctccggcac?cggccaggcg?gcgggcggta?cgggcaccga?gggcgccggt?gccgccggtg?108840
atcaggacgg?ttccggtggg?cttccagtcg?cggggcgtcc?cgggccggac?ggcggcgagg?108900
cggcggccga?agaccgcacc?gggccggacg?gcgagctggt?cctcgccctc?ggggtcggcg?108960
aggacggcgg?cgagccgttc?ggcggtccgc?gcgtcgacag?cgagcggcag?atcgacggtg?109020
ccgccccagc?gctgcgggtg?ctccagcgcg?gcgacccggc?cgagtccgtg?gacggcggcc?109080
tggagcggtg?cggcgacggt?ctcggcgggc?gagacggcgg?cggcgccacg?ggtgaggcac?109140
cacagcgggg?cgtcggtgcg?ggcgtcgccg?agcgcctgga?ccagggtcgc?ggtcagggcc?109200
gcgccggccg?ggacgccgcc?ggggagggcg?ccggtcccgt?caccgggttc?cccggcgacg?109260
gcgagcaggg?agaccacacc?ggtgaacggc?ccggtggcgt?cgagccgttc?gcggatcgcg?109320
gcggcgagtc?cggcgcggtc?cttgccggag?acctccagga?cctgggcgcc?cgcgccgagc?109380
gcggccagga?cggcggaggt?ccacggatgg?tcggcgtggt?cggcgggcac?gacggcgagc?109440
caggtgccgg?cgggggtgcc?ggcggtggcc?cggttcaggg?gccgccaggc?gatgcgctgg?109500
cgccagccgt?ccacggtggt?ctggtcgccg?tgcttgcggc?gccagtcccg?cagggccggc?109560
aggacgcgca?gcaacgcgtc?gccgtcgacg?ccgagttccc?cggcgaggga?gtcgaactgc?109620
tcgtcctgga?ccgccgccca?gaaggcggcg?tccccggcgt?cggccgtggt?gccggtggcg?109680
gcggcgggtg?cctcgtcggg?ccagaaccgc?agtcggcgga?acgggtaggt?gggcaggtcg?109740
acgcggcggg?cgccggtgcc?gtcgagcagt?gccgcccagt?cgagtccctg?accggccgcg?109800
tgcagccggg?ccacggcggt?gatcagggcc?tgctcctcgt?cgcgtccggt?gcgcagggcc?109860
gggacggccg?tgggggccgg?gcggttctcg?tcggcgaggg?tgtccagggt?ctcctgggcg?109920
aggccgcaca?ggattccgtc?ggggccgagt?tcgaggtagc?gggtggcgcc?gcgtcccgcg?109980
agggtgcgca?caccgtcgcc?gaagcggacc?gcctcgcgga?cgtgccggac?ccagtacccg?110040
gggtcgcaca?cctgcgcgtc?ggtggccgcg?tccccggtga?ggttggagac?caggggcagc?110100
gtcggcgggg?cgtacgacac?actccgggtg?acccgttcga?agtcctgaag?catggcgtcc?110160
atgtgcagtg?agtgaaacgc?atggctcacc?cgcaaacgcc?tagtcttccg?gccctgttcg?110220
gcgagggcct?cggcgagcgc?ggtgaccgcc?ttctcgtcgc?ccgagaccac?cacggactcc?110280
gggccgttga?cggcggcgag?gcagatttgg?tcggtcaggt?acggggcgat?ctcgtcctcg?110340
gtggcgcgca?cggcgagcat?ggcgccgccc?gccgggagtg?cctccatgag?gcgggcgcgg?110400
gcggagacga?cgcggcaggc?gtccggcagg?gagaggaccc?cggccacgtg?ggcggccgcg?110460
agctcgccga?ccgagtgccc?ggcgagcagg?tcgggccgta?cgccccagga?ctcgaccagc?110520
cggtacaggg?cgacgccgag?ggcgaacagg?gcgggctggg?tccagccggt?ccggtccagg?110580
agcgccgcct?cgggggtgcc?ctcgtcggcg?aacatcacgt?cgcgcagcgg?gcgttcgagt?110640
tcctggtcga?agtgggcgag?gacctcgtcg?agggcggtgg?cgaagaccgg?gaagcgggcg?110700
tagagggcgc?ggcccgcccc?ggggcgctgg?gagccctgcc?cggggaagag?gaacgcggtc?110760
cggccgccgg?gggccgcgcg?gccgcgcagt?acggcggggt?gggcgcggtc?ctcggcgagg?110820
gcggtgagcg?cgtcgaggag?gtcgtcgcgg?ccggccacgg?cgaggacggc?ccggtgctcg?110880
aaggcggagc?gggtggtgcc?cagggagagc?gccaggtcgg?cggtggccgg?cggctgcgcc?110940
gcaccggcgg?tgagccggtc?gcggagccgg?gcggcctgct?cggtcaggga?gtccgcggtg?111000
gccgccgaca?gcggcagggg?cagcagccgt?gcggcgtcgg?tggcgtgcgt?ggcgggctcc?111060
gtgtcccgct?ccggggcggc?cgggccggtg?ggggcctgtt?ccaggatgac?gtgcgcgttg?111120
gtgccgctgg?cgccgaagga?ggagacagcg?gcgcggcgcg?ggcgtccggt?ctcgggccag?111180
tcggccgcct?cggtcagcag?gtggaccgcg?tccgggtccc?aggcgacgtg?gcgcgagggc?111240
ttctcggcgt?gcagggtgcg?cggcagcgtg?ccgtgccgca?tggcgaggac?catcttgatg?111300
atgccggcga?cgccggaggc?ggcctggctg?tgaccgatgt?tggacttgac?cgagccgagc?111360
agcagcggct?gcccctcggg?ccggtcctgc?ccgtacgtcg?ccaggagggc?ctgggcctcg?111420
atggggtcac?cgagggtggt?cccggtcccg?tgtgcctcca?cggcgtcgac?ctcgcgggcg?111480
gtgagtccgg?cggcggccag?cgccttgcgg?atgacgcgct?gctgggaggg?gccgttgggg?111540
gcggtgagac?cgttggaggc?gccgtcctgg?ttgatggcgg?agccgcgcag?gaccgcgagg?111600
acctcgtggc?cgcgccggcg?ggcctccgag?aggcgctcga?cgacgagcat?gcccacgccc?111660
tcggaccagg?ccgtgccgtc?ggcggcgtcg?gagaagggct?tgcagcggcc?gtccggggag?111720
agggcgccca?tctcgccgaa?ctcgacgaag?ccgaccgggg?tggacatcac?ggtgacaccg?111780
ccggccaggg?cgagcgagca?ttcgccggag?cggatcgcct?gcgcggcgag?gtgcagggcg?111840
gtcagggacg?acgagcaggc?cgtgtcgacg?ctgacggagg?ggccctccag?gccgagggtg?111900
taggagagcc?gtccggagag?gaggctcgcc?gactgggcgg?tctcgacgtg?cccggactgc?111960
ccgatggcgg?gacggtagtc?gccgctgccg?ccgccgacga?agacaccggt?gtcgccgccg?112020
cgcagcacgg?cggggtcgat?cccggcccgc?tccagcgcct?cccaggcggc?ctggaggacg?112080
atccgctgct?gcgggtcgat?gaccagggcc?tcgcgcgggg?agatcccgaa?gaaggcgggg?112140
tcgaagtcgg?cgacgtcgta?gaggaatccg?ccctcgcggg?tgacgctgcg?gccccggccg?112200
tcctcgtcgc?cgtggagcag?cttctccagg?tcccagccac?ggtcggtggg?gaagccgccg?112260
atggcgtcgg?taccggcccc?gaccagttcc?cacaggtcct?cgggcgagcg?gacgtcgccg?112320
gggtagcggc?agctcatgcc?gacgatgacg?acggggtcgt?ccgcgtcggc?ggcggcgcgt?112380
gccacggggg?cgccggtgcc?gggcccggtg?tcctcgccga?ggagttcggt?gaggaggtgg?112440
gcggcgagcg?cggcgggggt?cgggtagtcg?aagaccaggg?tcgcgggcag?ggtgagcccg?112500
gtggccgtgg?tgaggcggtt?gcgcaggtcg?accgcggtga?gcgagtcgaa?gccgaggtcg?112560
ttgaaggcgt?tctcggccgg?gacggcggcg?gcgccggtgt?ggcccagcac?cgaggcgatc?112620
tcggtgagca?cggtgtcgag?gagggtgcgc?ggacgctcgg?aggggtcgga?ctgccgcagc?112680
cgctcgcgca?gcgcggaggc?ggtaccggcg?tccgcgccgt?cgccaccggt?ggtgctcagg?112740
gcctcgcggg?cctcgggcac?gccggtgagg?agcagaccgg?cgcgggtgcg?ggtgaacgcc?112800
ggggcgaacc?ggtcccaggc?cacgtccgcg?acggtcaccg?aggcgggagc?ggccgggttg?112860
gcggcggcct?cgccgatcgc?gggggcgagg?gcgtcgagcg?cgcgggccgg?ctccatggcg?112920
ggcaggccgt?tggcgcgcag?gtgggcggcg?agaccgtccg?gcccggcgcc?ctgccaggcg?112980
ccccaggaga?ccgagacggc?gttggtgccg?tgggcgcggt?gtcgctggac?gagggcgtcc?113040
aggcagactc?cggccgcggc?gcccgcgccc?tggccgccga?cgccccagac?ggcggagatg?113100
gagccgaaga?cgacgaaggc?gtccaggtca?cggtcgccga?cggcggtggt?cagcgcctcg?113160
taggcggcgc?gcgccccggt?gacaccgggc?gtctcctcgc?cggtgtcccc?ggtgtggagg?113220
acggcggtca?gcggccggtc?gtcggcctgc?gccgccagcg?cctcggtgag?cggggcggcg?113280
tcggccgggt?cggggtggcg?gacgacggtg?agggtggcgc?cgagcgcctc?cacctcggca?113340
cgcagggcgg?tggtggcggc?gtcctcgggg?ccggccgggc?cggcgagcag?caccccggtg?113400
gcgccgtgcg?cggcgagcca?gcgggcgacg?tgcccgccga?agccctccgc?ccggcccgtg?113460
accaggacgg?tcccggcggg?gtgccaggtg?atgtccggag?cgggagcggc?ggcccgggac?113520
agccggcggc?cgaaggcgcc?ggaggcgcgc?agcgccacct?ggtcctcggc?cgggccgtcg?113580
gtgcgggcga?cggtcaggac?ggcgcgcaga?cggtcgacgg?tgcgggcgtc?ggcgacgtgg?113640
tcgacgtcga?ccagtccgcc?ccaccgttcg?ggctcgtcca?gggcgagtac?ccggcccagg?113700
ccccacaggg?cggcgcggtc?cgggtcggcc?gccgggtcgg?agcggccgac?ggagacggcg?113760
tcgcgggtga?cgcaccacag?cggggcgtcg?atcccggcgg?ccgccagcag?gcggagcagg?113820
gtgtcggggc?gggcggtgcc?gtccgtcgcg?gtgccggcga?gcagcgagag?gacaccggcg?113880
tacgcggtgc?cgtcggcggc?cccgtcgagc?agggcggcgg?tgccgtcctc?gtcggcgggg?113940
acggcgaggt?ggacggtgtg?ctcgccgaag?gtggcggcca?gggcctgggt?ccacgcgtcg?114000
tcgtgcccgg?ccagggtcag?gaccagccag?ggtcggcccg?ttccgtcgtc?ggcggtgttc?114060
ccgaggggga?cgggctgcca?ggtgacgcgg?tagcgccagc?cgtcgagcag?ggtgcgctcg?114120
gacaggccac?ggcgccaggt?ggagagggcg?ggcagcacgt?tcgacaggac?cgcgtcgtcc?114180
aggtcgaggg?tggcggagag?cgactccagg?tcctcgcgct?ccacggcggc?ccagaacgcg?114240
gcgtccgccg?ggtcctgcgc?ggtggccgtg?tgcggcccgg?tggccggctc?gggccagtac?114300
agctcgcgct?ggaaggcgta?ggtcggcagg?tcggtgcggc?gggcgccggt?gccggtgaac?114360
caggcggtcc?agtcgacggc?gacaccggcg?gtgtggagcc?gggccagggc?ggtgagcagc?114420
gagtgttcct?cgggtcggtc?cttgcgcagc?gccgggacgc?tcacgccgcc?gcttccgtcg?114480
gcggccgtgt?cgaggacccg?ggcggccatg?ccggtgagga?ccccgtcggg?gccgatctcc?114540
aggtaggcgt?cggctcccgc?ctcggcgagg?gcgcggacgc?cgtcggcgaa?gcggacggtc?114600
tcgcggacgt?gccgcaccca?gtactcgggg?tcggtgagct?gaccgggctg?ggcgagggcg?114660
ccggtgacgt?tggagaccac?cgggacgcgc?ggctcggcgt?actccaggct?ctccgcgacc?114720
cggcggaact?cggcgagcat?cggttccatc?agcgccgagt?ggaaggcgtg?actgaccggc?114780
agaggctgcg?tcttgtgccc?ctcccccgcg?aactcggccg?ccagggccag?gacttcctcc?114840
tgctcaccgg?cgatgacgac?ggagtcggga?ccgttcacgg?cggcgaggga?caggccctcg?114900
gtcagccggg?gcacgacctc?ggcctcggtc?gcccgcacgg?ccaccatcgc?cccgcccgtg?114960
gggagttcct?gcatcaggcg?ggcgcgggcg?gcgaccagcg?cgcaggcgtc?gtcgagcgag?115020
aagactcccg?ccacgtgcgc?cgccgcgatc?tcgccgaccg?aatgacccgc?cacgaactcc?115080
ggcgcgacac?cccacgactc?caccagccgg?aacaacgcca?cctccaccgc?gaacagcgcc?115140
ggctgcgtgt?acccggtcgc?ctccagcagc?gccgccgcct?cggaaccctc?ctcagcgaac?115200
agcacctccc?gcagcgaacg?ctccagcccc?gtgtccagac?gggccaccac?cgagtccagc?115260
gcctccgcga?acaccgggaa?acgctcgtac?aactcccggc?ccatccccgc?acgctgcgaa?115320
ccctggcccg?agaagagcag?ggcgaggcgg?cgttcccagg?cgcggtcgcg?gacggtctcc?115380
aggggttcgc?ccccggcggt?gaccaggtgg?acggcgcggt?gggcgaaggc?ccctcggccg?115440
gtggccaggc?tgtaggcggt?gtcgagcgcg?gggacctcgg?gccgggcctg?tgtgaaggcg?115500
gtcagccgcg?cggtctgggc?cgccagggcg?tcctccgagc?gggccgagac?cagccagggc?115560
acgacggacg?gctcggtgac?cggttccggg?gtctcggcgg?tggccggttc?gggctgctcc?115620
aggatgacgt?gcgcgttggt?gccgctcacg?ccgaaggcgg?agacgcccgc?ccggcgcgca?115680
cggcccgtct?cgggccaggc?gcggtgctcg?cggagcagtt?ccacggtgcc?gtcggaccag?115740
tcgacgtgcg?aggacggcgc?gtcgacgtgc?agggtgcgcg?gcagttcgcc?gtggcccagg?115800
gcgaggacgg?tcttgatgac?accggcggcg?cccgcggcgg?cctgggtgtg?gcccaggttg?115860
gacttgacgg?tgccgagcag?cagcggctgc?tccgggtcgc?ggccctcgcc?gtaggcggcg?115920
atcagggcgt?gggcctcgat?cgggtcgccc?agggtggtgc?cggtgccgtg?cgcctcgacg?115980
gcgtcgacct?ccgccggggt?gaggtgcgcg?tcggccagcg?cctggcggat?gacgcgctgc?116040
tgggcgcggc?cgttgggcgc?ggtgaggccg?ttggaggcgc?cgtcctggtt?gacggcggag?116100
ccgcgcagca?cggcgaggac?cgggtggccg?tgacgacggg?cgtcggagag?ccgctccagg?116160
acgaggacgc?cggcgccctc?gccccaggcg?gtgccgtccg?cggcgtcggc?gaacgccttg?116220
cagcggccgt?cgccggccag?gccgccctgc?gcggtgaact?ccacgaaggc?gtccgggctc?116280
gccatcaccg?agacgccgcc?ggcgagggcc?agggtgcact?cgccggagcg?cagcgccccg?116340
gcggccatgt?gcagggccac?cagcgccgag?gagcaggcgg?tgtcgacggt?gaccgccggg?116400
ccctccaggc?ccagggtgta?ggacaggcgg?ccggacatca?cgctggcggt?ggtgccggtc?116460
gcggcgtggc?cgcgcacgtc?ggtggtgccg?cgccgcagca?cggtggcgta?gtcctggccg?116520
ttggtgccga?cgaagacgcc?ggtggcgctg?gagcgcaggc?ccgtcgggtc?gatgccggcc?116580
cgctccaggg?cctcccagga?ggtctccagc?agcaggcgct?gctgcgggtc?catcgcaagg?116640
gcctcgcgcg?gggagatgcc?gaagaacgag?gcgtcgaaga?gtccggcgcc?ctggaggaag?116700
ccgccctcca?gggtggcgga?gccgccacgg?gccagcgagt?ccaggtccca?gccgcggtcg?116760
gccgggaagc?cggagacggc?gtcgcggccc?tcgccgagga?gctgccagag?ctcctcgggc?116820
gactcgacac?cgccggggaa?gcggcagccc?atgccgacca?cgacgaccgg?gtcggtctcc?116880
gtggcgcggg?gagcctcgcc?ggccgcgttc?ccgcccgccg?ccggctcggg?caggtcgccc?116940
aggatctcgg?tcaggaggtg?agcggccagg?tcgcgggcgg?tcgggtggtc?gtagacgagg?117000
gtggcgggca?gccgcaggcc?ggtggtggcg?cccagggtgt?tgcgcagttc?gacggtggtg?117060
agggagtcga?agccgaggtc?ggtgaaggcc?tggtcggcct?cgacggcgtc?cgggtcgggg?117120
tgaccgagga?cggcggcgac?ctgggcgcgc?aggaagtcca?gcacgtaccg?ctcgcgggcg?117180
gggccggtca?gggcggcgac?ctggcggcgc?agcgccggtt?cggtgtcgcc?gtgggcggtg?117240
gccgcgccga?cggtggcgcg?tacctcgggc?aggtcgccga?cgagggcgcg?gtgcggggcg?117300
aagacggtgg?cgtagcgctg?ccagtcgatg?tcggcgacga?ggagcgcggt?gtcgcggtgg?117360
ccgacggcgg?cgtcgagggc?ggcgagggcg?tcctcggggc?tcatcggggt?gaagccgcca?117420
cggcggaccc?ggtcctcgac?gccggtgccc?tcgccggcca?tgccggtgcc?ggaccagggg?117480
ccccaggcca?ccgaggtggc?aggcaggccc?tgttcgcgcc?ggtgttcggc?gagggcgtcg?117540
aggtaggcgt?tggcggcggc?gtagttggcc?tggccggcgg?cgccgagggt?accggcggtc?117600
gaggagaaca?ggacgaagtc?ggtgaggccg?aggtcgcggg?tcagctcgtg?caggtgggcg?117660
gcggagcggg?ccttggcgtc?gaggacggcg?gcgaaccgct?ccggggtgag?ggtgtccagg?117720
aggccgtcgt?cgaggacgcc?cgccgcgtgc?accacggtgg?tgagggggcg?gtcggcgggc?117780
acctcggcca?ggagcgcggc?gagcgcctcc?cggtcggcgg?tgtcgcaggc?ggcgagggtg?117840
acctcggcgc?ccagttcccg?cagctcggcg?gcgagttcgg?cggcgccggg?ggcgtccgcg?117900
ccgcgccggc?tggtcagcag?caggtgcggc?gtgccgcgcc?cggccaggag?ccgggcgacg?117960
tgggcgccga?gggcgccggt?accgccggtg?atcaggacgg?tgccctcggg?ggcgaacgga?118020
cgcgccggtt?cctggggcgc?cgggtggtgg?gcgatccgcc?gcgcgtaggt?ggcggaggcg?118080
cggacggcga?gctggttctc?cgtgccgggc?acggccagga?ggtgcgccag?ccggcgggcg?118140
acgcgggtgt?cgaactgctc?gggcaggtcg?accagggcga?ggcggcgtcc?ggggttctcc?118200
agggcggcga?cccggccgag?cccccacaca?cccgcctgcc?cgggacgggc?cagccggtcg?118260
gcgcgtccgg?tgctcacggc?ctgccgggtg?acgatccaca?ggggcgcggt?gatcccggcg?118320
tcgtccaggg?cgttcagggc?ggcggccgtc?ggcgccacgg?cgcccgtccc?tgccacgtcg?118380
tcggcggtgg?cggcggtgtc?gagggccggc?agggcgagga?cgccggtgaa?gccgtcctcg?118440
gggcgcggca?gccggcgcag?ggtgtcggcg?agcgcggcac?ggtcgggggc?cgcgaggtcg?118500
acggtgacct?cggcggtgtc?caggccgagg?gtgtccagga?gggcggcggt?ctcgggcgcg?118560
gccgtaccgg?tgggacgcag?gaccagccag?gtgccctcgg?gccgtccggt?gggggcgccg?118620
tcgagcggct?tccacacgat?ccggtggcgg?cggccgtcgg?cggcggcctg?tgcggtgcgg?118680
cggcgccgcc?acgaggacag?ggccggcacc?agggcggaca?gcgtgtcgtc?gtccaggccg?118740
aggtcggcgc?cgagcgtggg?caggtcggcc?cgctcgacgg?ccgaccagaa?cgcggcgtcg?118800
gcgccggtgt?cggcggggcc?cgcggccgtg?gccggggtga?aggtggtgtc?gggccagtag?118860
cggctgcgct?ggaaggcgta?ggtgggcagg?tcgacgcggc?gggcgccggt?gccctcaaag?118920
gcgccggtcc?agtcgacggc?ggtgccgtgg?acgtgcagcc?gggcgagggc?ggcggtgagg?118980
aacggcacct?cgtcgcggtc?gcggcgcagc?gcggggacga?cggtgacggg?ccgggcgccg?119040
gtggcgtcgg?ccgggtcggc?gtcgaggacg?tcgcgggcgg?cggcggagag?ggtgccgtcg?119100
ggaccgagtt?ccaggcagga?ggtgacgccc?tggcgggcga?gggtgcgcac?ggcgtcggcg?119160
aaccggacgg?tggcacggac?ctggccgacc?cagtactcgg?gcgaacgcag?ttcctcgggg?119220
gtggcggggg?cgccggtgac?ggtggagacc?accggcacga?gcggcgtctc?gtaggtgagg?119280
ccgcgggcga?cgcgggcgaa?gtcgtcgagc?atggcgtcca?tgcgcggcga?gtggaaggcg?119340
tggctgacct?tcagcgcgcg?ggtgcggcgg?ccgtcctcgg?cgaggcgggc?ggcgacggcg?119400
gcgaccggct?cctcgtcacc?ggcgatcacc?acggcgcgcg?ggccgttgac?cgcggcgagg?119460
gagatccggt?cctcgcctcc?ctccaggagg?ggcagtacct?cttcctcgct?cgcctcgacg?119520
gcgaccatgg?cgccgcccgc?cggaagggcg?gccatgaggc?ggccacgggc?ggcgacgagg?119580
gcgcaggcgt?cgtccaggga?gaagaccccc?gccacgtggg?cggcggcgat?ctcaccgacg?119640
gagtggccgg?cgacctggtc?ggggcgtacc?ccccaggact?cgacgagccg?gtacagcgcc?119700
acttcgaggg?cgaacagggc?gggttgcgtg?tacgccgtgt?cgtccaggag?cgcggcctcg?119760
gcggtgccct?cctcggcgaa?gagcacctcg?cgcagcgggc?ggtccagttc?ctggtcgaag?119820
cgggtgagga?ccgcgtccag?ggcttcgccg?aagaccgggt?gacgctcgta?caggtcccgt?119880
cccatggccg?ggcgctggct?gccctggccg?gtgaagagga?aggcgagccc?tcctcgtgcg?119940
ggggcgccgg?tgagcagcga?ggcgtcgggg?gcgccctcgc?gcagcgcggt?gagcgcccgc?120000
agcaggccgt?cccggtcgcc?ggtgaggacg?gcggcgcggt?gctccaggac?gccacgggtg?120060
gtggccagcg?agtgggccag?gtccaccagc?ggtacgtccg?gacggccggc?gaggtgtccg?120120
gcgagccgct?cggcctgctc?gcgcagggcg?gccggggtcc?gggcggagag?cacgacgggg?120180
acgcccgggg?gcagggtggc?cgggtcgccg?gcgggggccg?gggacgcgga?gggctcggtc?120240
gcgggctcct?cgggcgcctg?ctcgacgatg?gtgtggacgt?tggtgccgga?gaggccgaag?120300
gaggagacgg?cggcccggtg?cgggcgtccg?gtctcgggcc?acggcacggt?ctcggtggcc?120360
aggtcgatgg?cgccggagcc?ccagtcgacg?tggctggagg?gggtgtcgac?gtgcagggtg?120420
cgcgggacgg?tgccgtgccg?catcgccatg?accatcttca?tgacaccggc?gatgccggag?120480
gccatctggg?tgtggccgat?gttggacttc?accgagccga?gcagcagcgg?ccggtccccg?120540
ggccggtcct?ggccgtacgt?cgccagcagg?gcctgggcct?cgatggggtc?gccgagggcg?120600
gtgccggtgc?cgtggccctc?gaccacgtcc?acctcgcccg?gggtgagccg?ggcgttggcg?120660
agggcctggc?gtatgacgcg?cgcctgggag?gggccgttgg?gggcggtgag?gccgttggag?120720
gcgccgtcct?ggttgacggc?ggagccccgg?atgacggcga?ggacggggtg?gccgttgcgg?120780
cgcgcgtcgg?acagccgctc?gacgaggacc?aggccgacgc?cctcggccag?gctcatgccg?120840
tcggcgccct?cggcgtacgc?cttgcagcgg?ccgtcggggg?ccatcgcgcg?ctggcggctg?120900
aagccggtga?acgcctgcgg?ggtggccatg?acgctgacgc?cgcccgccag?ggcgagggtg?120960
gactcgccgt?tgcgcagcga?ctggcaggcc?aggtggagcg?cgaccaggga?ggaggagcag?121020
gcggtgtcca?gggtgacggc?cgggccctcc?aggccgaagg?tgtaggcgag?ccggccggac?121080
atcacgctgg?agatggtgcc?ggtgatcagg?tggtcctcgg?cgccctcgga?gccggcgccg?121140
cccgcggtgt?agtcctggta?gctggcgccg?atgaaggtgc?cggtcatgct?tccgcgcagg?121200
gtcgcggggt?cgatgcccgc?gcgctcgatc?gcctcccagc?cggtctccag?cagcaggcgc?121260
tgctgggggt?ccatcgccag?tgcctcacgc?ggggagatcc?cgaagaagcc?ggcgtcgaag?121320
tcggcgacgt?cgtggaggaa?tccgccctgc?gtggagtagg?tggtgccggg?ccggtcgggg?121380
tccgggtcgt?agagggcgtc?ggcgtcccag?ccccggtcgg?cggggaagcc?ggtgatggcg?121440
tcggcgccgg?ccgcgatcag?ctcccacagg?gcctcgggcg?aggtgacgcc?gcccgggtag?121500
cggcagctca?tcgcgacgac?ggcgatcggc?tcgtcgtcgg?tggcggccgt?ggtgcggacc?121560
gggccgtcgg?ggccggcggc?gggaccgccg?gccaggcccc?gcaggtggcc?cacgagggtg?121620
agcgggtccg?ggtagtcgaa?cacgagggtg?ctcggcaggg?tgaggccggt?gacggaagcc?121680
agccggttgc?gcaggtcgac?cgcggtgagc?gagtcgaacc?cgatgtcacg?gaaggcgcga?121740
cgctccgaca?gcacctccgg?ggaggcgtgg?ccgaggacgg?tggccgcctc?cgagcggacg?121800
agttccagca?ggaggcggtc?ctgctcgccg?gcgggcaggg?agcgcaggcg?gtggatgaac?121860
tctccggcct?cgccggcgcg?ggcctcctgc?tgctcggtga?ggcggcggac?ctcgggcacg?121920
ttctcgaaga?gttcggtggg?ccgcgaggag?gtgaagacgg?ggtggtagcg?gtcccagtcg?121980
acgtcggcga?cggcgacggc?gccctggtcc?ccgtcgagga?cctgccggag?cccggcgagg?122040
gcgaggcgcg?ggtccatgaa?ctccaggccg?ctgcggcgga?tctggccggg?gtcgacccgg?122100
ccgagcttca?tgtcgtcggc?ccagatgccc?caggagacgg?cggtgccgtg?ggcgcctcgg?122160
gcgcaccggt?gctcggcgag?cgcgttgacg?tgggcgttgg?cggcgacgta?cgcggcgtgc?122220
cggccactcc?cccacatacc?ggcggtggac?gagtagagga?cgaaggcgtc?gagctggtcg?122280
tcgtcgagga?gttcgtcgag?gtgggcggcg?cccgcggtct?tggcgtggac?gaccttggcg?122340
aacgcgtcga?ggctggtctc?ctcgatggac?tggagctcga?tgacggcggc?ggtgtggaag?122400
acgctgcgga?cggtgcggcc?ctcggcggtg?aggccgtcga?ggagcgcggc?gaccgcctcg?122460
cggtcggtga?cgtcgcaggc?ggcgacggtc?acccggcagc?cgcgttcgcc?gagttcggcg?122520
gcgagttcgg?cggcgccggg?ggcgtccgcg?ccgcggcggc?tggtgaggac?caggtcgcgg?122580
gcgccctggt?cggcgagcca?gcgggccagg?tgcgggccga?gcgttccggt?gccgccggtg?122640
accaggacgg?tgccgcgcgg?gctccagcgg?ccggtgccgg?tgggcgccgg?ggccggggag?122700
acgcggcggg?ccaggacgcc?ggaggcgcgg?acggccagct?ggtcctcgcc?ggtggtgccg?122760
gccaggacgg?cggcgaggcg?ttcgcccgcc?cggcggtcca?gggtctcggg?caggtcgacg?122820
gtgccgcccc?accggtccgg?gtgttccagg?gccgcggtcc?agccgaagcc?ctggacgagg?122880
gcctgggcgg?gccgggtgag?gcggtcggcg?cgcccggtgg?agacggcgcc?gcgggtcagc?122940
gcccacaggg?gtgcctcgat?cccggcgtcg?ccgagggcct?gcgtcagcgt?gacgctgagg?123000
gcgagaccgg?tggtgaggac?cgggtgggcg?gcgccggtgg?actcgtcgtc?ggccagcagg?123060
gagaccaccg?cggccggttc?gggcaggtcg?cgcagccgct?ccgtgagagc?cgcccggtcg?123120
gcgtcggccc?cggtcagcgc?gaggggcacg?gtccgcgcgc?cgtgcgcggt?cagctgctcc?123180
gccacggcgg?cggcgtactc?ggggtcggtg?ccctccgcgg?tgacgagcag?ccaggtgccg?123240
tccagggtcg?cggaggggag?cgcgccgagc?ggcttccagg?tggcgcggta?gcgccaggac?123300
ccgacggtgg?aacggtcgcg?cctgccacgg?cgccaggtgg?agagggcggg?cagcagcggg?123360
gcgagcgcct?cccggtcgag?ttccaggcgg?gaggcgaggg?actccgcgtc?ctcctgctcg?123420
acctcggccc?agaactcggc?gtcggcgggg?tcgccgtcgc?cggagccctg?cgggcgggcg?123480
gagacggccc?acaggtgctc?acgctggaag?gcgtaggtgg?gcaggggtgt?cctgcgggcg?123540
ccggtgtccg?cgtagaccgc?gttccagtcg?gcccggccgc?cgcgtaccca?ctgttcggcg?123600
agggaggtga?ggaagcgcgc?ggtgccgccc?tgttcgcggc?gcagggtgcc?gacggcggcg?123660
gccgggcggc?cggcctcctc?ggcggtggcc?tggacggcca?tggtcagcac?ggggtgcggg?123720
ctgatctcga?cgaagagcgt?gtgttcggtg?tcgagcaggg?cgcgcacgcc?gtcctcgaag?123780
cggacggtct?gccgcaggtt?gcggtaccag?taggcggcgt?ccatgccggt?ggtgtcgagc?123840
gtggcgccgg?tgaccgtgga?gtggaacggg?acccgggcgg?cgcgcggtgc?caccggggcg?123900
aggaggtcga?ggagttcggc?ctcgatccgc?tccacctgtg?ccgtgtggga?ggcgtagtcc?123960
acggcgatcc?ggcgggcacg?caggtcgcgg?gcggcgaact?ccgcctggag?ggcgtccagg?124020
gcctcgggcg?taccggcgag?gacgacggag?cgcgggccgt?tgacggcggc?gacggagacc?124080
gctcccgcgt?ggggggtcag?gtactgctcg?gcctcggcgg?cggagacctg?gacggacatc?124140
atgccgccgg?ccccggccag?gacccggcgg?atcgcctggg?agcgcagggc?gacgacgcgg?124200
gcgccgtcgt?cgagggtgag?ggcgccggag?acgacggcgg?cggcgatctc?gccctgggag?124260
tggccgatca?cggcgtcggg?ggtgacgccg?tgggcccgcc?acagctccgc?gagggagacc?124320
atcacggccc?aggtcgcggg?ctgcacgacg?tcgacccggt?ccagggtcgg?cgcgccgtcg?124380
gcctggcgga?cgacgtcgac?gaggtcccag?tcggtgtacg?gggccagggc?ggccgcgcag?124440
gcgtggagcc?gctcggcgaa?caccggtgac?gtgtcgagga?gttcggcgcc?catgccggcc?124500
cactgggagc?cctggccggg?gaagacgaag?acggtgcggc?cgtcggtgtc?ggcggtgccg?124560
tggaccacct?ggccggtgga?ctcgccggcg?ccgaacgcgg?cgagcgcgtc?ggtgagttcg?124620
ccggcgtccg?cgccgagggc?gacggcgcgg?tgctccagga?cggagcgtgc?ggtgatcagg?124680
gtgtggccga?cgtcggcggg?gtgcggtgcc?gcgccggagg?tgacgtgggc?ggcgaggttg?124740
gcggcctgct?cgcgcagggc?ggagggggcg?gcggccgaga?ggatccacgg?cagggtgccg?124800
cccgtgggca?gggcgggtcc?ggcggcgggg?gcgggctcct?cggcgggggc?cgcctgttcc?124860
aggatggcgt?gcgcgttggt?gccgctgatg?ccgaaggagg?agacggcggc?gcgcagcggg?124920
cggtcgtccc?gggcccagcc?ggtgttctcg?gtgacgaggc?ggacggtgcc?gccggaccag?124980
tcgatgtggc?tggagggctc?cgtggcgtgc?agggtgcgcg?gcagggtgcc?gtggcgcatc?125040
gccatgacca?tcttgatgat?gcccgcgacg?ccggcggccg?actgggtgtg?gccgatgttg?125100
gacttcaccg?agccgagcag?cagcgggttc?tcggggtcgc?ggtccctgcc?gtaggtggcg?125160
tgcagggcct?gggcctcgat?ggggtcgccg?agggcggtgc?cggtgccgtg?tgcctcgacc?125220
gcgtcgatgt?cgtcggtggt?gaggccggag?gcggccagcg?cctggcggat?gacgcggacc?125280
tgggaggggc?cgttgggggc?ggtcaggccg?ttggaggcgc?cgtcctggtt?gatggcggag?125340
ccgcggacga?cggcgaggac?ctcgtggccg?ttgcggcggg?cgtcggagag?ccgctccagg?125400
acgaggatgc?cgacgccctc?ggcgagggtc?atgccgtcgg?cgctctcgga?gaaggccttg?125460
cagcggccgt?cccgggcgag?ggcccgttgc?cggctgaagg?cgatgaacgg?catcgggttg?125520
gtcatgacgg?tggcgccgcc?cgccagggcg?agggtggtct?cgccgttgcg?cagcgactgg?125580
caggccaggt?ggagcgccac?cagcgacgag?gagcaggcgg?tgtcgacggt?gacggccggg?125640
ccctccaggc?cgaaggagta?ggcgaggcgg?ccggagagca?cgctggggct?ggagcccgtg?125700
acggcgtggc?ccgcggaccc?gtcgtccatg?gagacgccgt?agtcctggta?cgtggagccg?125760
atgaaggtgc?cggtgggcgt?ggagtgcacg?gcggccgggt?cgatgcccgc?gtgctcgaac?125820
gcctcccagg?tggtctccag?caggaggcgc?tgctgcgggt?ccatggagac?ggcctcgcgc?125880
ggcgagatgc?cgaagaaccc?ggcgtcgaac?tcgcccgcgt?cgtgcaggaa?tccgccctgc?125940
gtggagtagg?tggtgccggg?ccggtcgggg?tccgggtcgt?acagcgcgtc?gccgtcccag?126000
ccccggttga?cggggaactc?cgagatcgcg?tcggtgttgt?cggcgacgag?ctgccagaag?126060
gcgtcggcgg?agcgggcgcc?gccggggaag?cggcagctca?tgccgatgat?ggcgatgggc?126120
tcgtcggtga?cggcggggcc?ggtcgccacg?ggggcggtct?cgaccgtgcc?gaggagttcg?126180
gcacgcaggt?ggcgcgcgag?ggcgagcggg?ttcgggtagt?cgaagaccag?ggtgctcggc?126240
agcgcgagtc?cggtgaggtg?ggcgaggcgc?ttgcgcagtt?cgacggcggt?cagcgagtcg?126300
aacccggcgt?cacggaacgc?ctttttgacc?ggcaccccct?cggcggaggt?gtggccgagc?126360
accacggcgg?cctcggcccg?cacgaggtcg?acgagcagcc?gctcctgttc?ctgctcggtg?126420
aggccgccga?ggcgctccgc?cagcccggag?acggtgccgg?tgctcccggg?agcagcgagg?126480
gccgcgacgg?tgtcgacggt?gtcgaagagg?cggctggacc?gggcggcggt?gaagaccggg?126540
tggtactgct?cccagtcgac?gtcggcgacg?gtcacggtgg?tctcgccgcg?tacgacggcc?126600
cggcgcagct?ccgtcatggc?ggtggcgggg?ttcagcagcc?gcaggccggc?gcgttccagg?126660
ttctccgaga?cggtccggtg?ggcgctggcc?atgccgacct?cggcccaggg?gccccaggcg?126720
acggaggtgg?cggcgaggcc?gcgcgagcgg?cggttctcgg?cgagcgcgtc?gaggtaggcg?126780
ttggcggcgg?cgtaggcgct?ctggcccgcg?ctcccccaga?ccccggcgac?ggaggagacc?126840
aggacgagga?agtcgaggtc?gtggccgtcg?aggagggcgt?cgaggtgggc?ggcgccgagg?126900
gtcttggcgg?ccatggcggc?ggcgacctgg?tcgagcgggg?tgtcggcgag?cggcgcggcc?126960
tggccgacgc?cggcggcgtg?cacgacgccg?gtgagggggg?cgtcctcggg?caccgcggcg?127020
aggacggcgg?cgagggcgtc?gcggtcggcg?ctgtcgcagg?cggtgagggt?gacgcgggcg?127080
cccagttcct?ccagttcggc?gcggagttcg?gcggcgccgg?gggcgtcggg?gccgcggcgg?127140
ccggtgagga?cgaggtgggc?ggcgccggag?cgggcgagcc?agcgcgcggc?ctcggcgccg?127200
agaccgccgg?tgccgccggt?gaccaggacg?gtgccggagg?cggtgaactc?gtcctcgcgg?127260
ggcagggcgt?cgccggggtg?ccggacgacg?cggcgggcca?gggtgccgcc?cgcgcggacg?127320
gcgagctggt?cctcgccgtc?gcgggtggcg?aggaggctga?ccagccgctg?ggtggccggg?127380
gcgtcgagga?cctccggcag?gtcgaccagt?ccgctccact?gctcggggcg?ttccagggcg?127440
gcgacccggc?ccaggcccca?ggcggcggca?cgggcggggt?gggtgagcgg?gtcgccgggg?127500
ccggtggaga?cggcaccgcg?ggtgaccgtc?cacagcgggg?cggtaacggc?ggcgtcgccg?127560
agggcctggg?cgaggaccac?gccgagggcg?aagccggccg?ggagtccgcc?ggccggtgcg?127620
tcggtgccgg?tggcctcggg?gcgggcggcg?tcggcgagcg?gcagcagcga?caggatgccg?127680
cggacaccgg?cggcgccttc?ggccgtggcg?ttctcgacgg?cgtcgcgcag?ggtggtggtg?127740
aggaggtcgc?ggtcgaggtg?ggaggcgtcg?agcaccaggc?gctcgacgac?ggcgccgtgg?127800
ccgcgcaggg?cggcgaggac?ggtgtcggcc?gcgccgtcgt?cctcggtggt?gacggccagc?127860
caggtcccgt?cgagcaccgg?ggcgctctca?gtaccggcgg?gctgccaggc?gatccggtag?127920
cgggccgcgt?cgaggacggc?gcgttcctga?cgggcgcggc?gccaggagct?cagcgacggc?127980
agcagcgtgt?agagggaggc?gtgttcctcg?tcgcgcagac?cgaggagccc?ggcgagcccg?128040
gtggcgtcgc?cgcgttcgac?ggcggtccac?agctcggcgt?cggccgggtc?gccggagccg?128100
tcaccggtgc?ggcgcacggt?cggcgcggtg?gtgtccggcc?agtaggtctc?gtgctggaag?128160
gcgtacgtag?gcagctcgac?ggtgccggcg?cctgccgggt?ggaccgcgcc?ccagtcgacg?128220
cggacgccgc?ggacgtggag?ccgggcgagg?gcggtgagga?cggactcgtc?ctccggtcgg?128280
ccggtgcgca?gcgtcgggac?ggcgtcggcc?tcgctgtcgt?caccgagggt?gtcctgggcg?128340
gcggcgcaca?gggagccgcc?ggggcccagt?tcgaggtagg?tggtggcgcc?ggcctcgtgg?128400
gcggcgcgca?cggcgtcggc?gaagcggacg?gtggagcgca?cgtggcggac?ccagtagtcg?128460
gcggtccgca?ggtggtcgcc?ctcggcgagg?cggcccgtga?ggtcgcaggc?cacggggacg?128520
gtgggctcgt?ggtacgtcag?gccctcggcg?acctcgcgga?aggcgtccag?cacggcgtcc?128580
atgcggggcg?agtggaaggc?gtggctgacc?cgcagccggc?gggtggcgcg?gccgaggccg?128640
gcgaagtgcg?cggcgatggc?cgcggtggcc?tcctcctcgc?cggagacgac?gacggccgac?128700
ggcccgttga?cggcggcgag?ggcggccacg?tcctcctgcc?cctggagcag?gggcaggacc?128760
tcgtcctcgg?acgcctggag?cgaccacatg?gcgccgccct?cgggcagggc?ctgcatcagg?128820
cgggcgcggg?cggcgaccag?cgcgcaggcg?tcgtccaggg?agaggacgcc?tgcggcgtgg?128880
gcggcgccga?tgccgccgac?ggagtggccg?aggagcacgc?cggggcgcac?gccccaggac?128940
cgcaccagcc?ggtacagcgc?ggtctccagg?gcgaacaggg?cgggctgtgt?ccagccggtc?129000
tcgtacaggg?cggcggcgcc?cggggtgccc?tcctcggcga?acatgacgtc?cttgagggag?129060
ccgtgcgggg?tgccggcggg?ggcgtcgacg?aggagcgggt?ccaggcgcgc?gacgacctcg?129120
tccagagcct?cggcgaagac?cgggtggcgc?tcgtacagtt?cgcggccggt?gccggggcgc?129180
tggctgccct?ggccggtgaa?gagcagggcg?gtgcggccgg?tgccaccggt?ctcgccgagg?129240
acgagcgccg?ggtcggggcg?gtcggcggcg?agggcggcca?gggcacggcg?ggcgtcgtcg?129300
gcggtgccga?cgaccacggc?gcgctgctcg?aaggccgggc?gggtggtggc?cagcgagtgg?129360
gtgaggtcgg?cgggggcctc?gtcggggcgc?gcgtcgaggt?gggcgagcag?ccgggcggcc?129420
tgggcgcgca?gcgcgggccg?ggtgcggccg?gagagggtcc?agggcaggac?ggtggcttcg?129480
gcgggcgggg?tgccggtgga?cccggcgggg?gcggactcgc?cctgttccag?gacgacgtgg?129540
gcgttggtgc?cgctgatgcc?gaaggaggag?acaccggcgc?gccgggggcg?gccggtctcg?129600
ggccacgcct?ccggctcctg?gaggatgcgg?acgtcgccgg?tctcccagtc?gacgtggcgg?129660
gaggggctgc?cggcgtgcag?ggtgcggggc?agttcgccgt?ggcgcatcgc?catgaccatc?129720
ttgatgatgc?ccgccacacc?ggcggcggcc?tgggtgtggc?cgatgttgga?cttcaccgag?129780
ccgagcagca?acggccggtc?cccgggccgg?tcctggccgt?acgtggcgag?gagggcctgg?129840
gcctcgatgg?ggtcgccgag?ggcggtgccg?gtgccgtgtg?cctcgaccgc?gtcgacgtcg?129900
gcggtggtga?ggccggccgt?gtccagggcc?tggcggatga?cgcgctgctg?ggaggggccg?129960
ttgggggcgg?tcaggccgtt?ggaggcaccg?tcctggttga?cggcggaccc?ccggaccacc?130020
gcgaggacgc?ggtggccgtt?gcggcgcgcg?tcggagagcc?gctccaggac?gagcatgccg?130080
acgccctcgg?accagccgac?cccgtcggcc?tcgtcggaga?acgccttgca?gcggccgtcg?130140
ggcgacaggc?cgcgctggcg?ggagaactcg?atgagggagg?tcggcgtgga?catcaccgtg?130200
acgccgccgg?ccagggcgag?cgagcactcg?cccgagcgca?gggcctgcat?cgcccagtgc?130260
atggcgacca?gggaggagga?gcaggcggtg?tcgacggtga?ccgccgggcc?ctccaggccc?130320
agggcgtacg?agacacggcc?ggaggcgatg?ctgggggcgg?tcccgctgcc?ctggtggccc?130380
tcgaaacgct?cgtcggcgag?ggtcgccgag?tagtcgctgt?acatgacgcc?ggcgaagaca?130440
ccggtacggc?tgccgcgcag?gcccaccggg?tcgataccgg?cgtgctcgac?ggctgtccag?130500
gacgcctcca?gcagcagtcg?ctgctgggag?tcggtggcga?gcgcctcacg?ggggctcatg?130560
ccgaagaagc?ccgcgtcgaa?ctcgcccgcg?tcgtgcagga?atccgccgta?gcgggtgtac?130620
gaggtgccgg?ggtggtccgg?gtcggggtgg?tagagggagt?cgaggtccca?gcctcggttg?130680
acgggcaggc?cgccgatcgc?gtcggtgccc?tcggtgacca?ggcgccacag?gtcgtcgggc?130740
gagccgacgc?cgccggggta?gcggcagctc?atgccgacga?tgacgatcgg?gtcgtcggcg?130800
gtggcggacg?tccgcggggc?gggggcgggg?gcctcggcct?cgggggcgtc?ggtcagttcg?130860
gccaggaggt?ggccggccag?ggccgcgacg?gtcgggtagt?cgaagatgac?ggtggcggag?130920
gtgcgcaggc?cggtggcggc?ggccagcccg?ttccgcagct?cgacggcggt?cagggagtcg?130980
aacccgagct?cctggaaggg?gcgttcgggg?tcgatgtcgg?cggcggaggc?gtggccgagg?131040
acggcggccg?tccggtcgcg?caccaggtcg?acgacggcct?ccgtgcgggc?ctgttcgtcg?131100
agccgggcga?gccgctgggc?gaggccgagg?gcggcctcgg?aaccggtgcg?caccgtgcgg?131160
cgggcgcggg?tgcggaccag?gccgcgcagg?agcgggggca?cctcgccccg?gccacgcagg?131220
gcggccaggt?cgaggcggac?gggcaggacg?gcggcgcggg?gcagggcgag?ggtggcgtcg?131280
aagagggcca?ggccctgttc?gacggtgagc?ggcggcgtgc?cggagcggga?catgcgctcc?131340
aggtcccgct?cggagagttc?gccggtcatg?ccgccgtcga?cgggcaccca?ggggccccag?131400
ccgagggaga?ggccgggcag?cccggcgtcg?cgacgcaggc?gggcgacggc?gtccaggaag?131460
gcgttgccgg?ccgcgtagtt?ggcctggccc?ggggcgccgg?tggtaccggc?gagggaggag?131520
aacaccacga?aggcggcgag?gtcgaggtcg?cgggtggccc?ggtgcagatg?ccagacggcg?131580
tcggccttgg?gccgcaggac?ggcggcgagc?cgctcctcgg?tgagggattc?gaccagtccg?131640
tcgtcgaggg?tgccggcggt?gtgcacgacg?gcggtgacgg?ggtgggcggc?cggtacggcg?131700
gcgaacagcc?ggtccacggc?ttccgggtcg?gcgacgtcgc?aggcggcgag?agtgacctcg?131760
gcgcccagcg?cgccgaggtc?ggcggcgagt?ccggcggcgc?cgggggcgtc?ggggccgcgc?131820
cggccggcga?gcaccaggtg?gcgtacgccg?cgctcggtga?cgaggtggcg?ggcgagggcg?131880
gcgccgaggc?cgccggtgcc?gccggtgacg?acaacggtcc?cctcggggtt?ccaggcggcg?131940
gcggtggtct?cgccgtcggg?gcggacgcgg?gcgagccggg?cggcgaacac?ggtgtcgccc?132000
cgcagcgcgg?tctgcggttc?ctcggcggcg?agggccgcga?cgagcgcggc?ggggtcggtc?132060
ccggcgacgg?ggtcgaggtc?gagcaggccg?aagcggtggg?ggtgttcggc?ctgggcggag?132120
cggaccaggc?cccagacggc?ggcggcggcc?gggtcggtga?gcggcccttc?gccgacggcg?132180
acggcgcccc?gggtgacgaa?caccaggcgc?gccccggccc?gggtgtcctc?ggcgagccaa?132240
cgctggatgt?gcccgaggac?gcgggcggtg?ctcgcgtgga?cctcggcggg?tacggcctcg?132300
gggtcgccgc?cgccgacggg?gacgagcacc?agggccggcg?tgtcgggtcc?ggcggcctcg?132360
gtgagcgggc?cgacggtgac?cccggcggcg?gtgagggcgg?cgccgagccg?gagggggtcg?132420
gggccgagca?gaccgacggt?gccgggggtt?tcgggggcgt?cggcgccgtg?gaggcgggtc?132480
cagtcgaggt?ggaagagggc?gtcgcgctcc?agcacgccgg?cggcggcccg?gcgcgcgtcg?132540
ggggcggagc?gcagcacgag?ggagccgacc?gaggcgacgg?gtgccccggt?ggtgtccgcg?132600
acggtgaggg?tgacggcgtc?gtcgcccgcg?ggggtgatgc?ggacccgggc?ctcggtggcg?132660
ccggccgcgt?ggagggtgac?gtcctgccag?gcgaacggca?ggccgccgcg?ggcgtcctcg?132720
ccgagcgggg?cgagggcggt?ggcgtgcagg?gccgcgtcca?gcagcgccgg?gtgcaggccg?132780
aacgaagagg?cgtcgcccgc?gggtcccgcg?tcgagagcca?cctcggcgaa?ggtctcctcg?132840
ccccggcgcc?agacggcgcg?caggccgcgg?aaggcggggc?cgtaggcgaa?gccggactcg?132900
gccagcccct?cgtagaagcc?gtcgaggccg?acactctcgg?caccggcggg?cggccagacc?132960
gccgcgtcga?actcctcgcc?gtggtgggcg?ccgttggtca?gggtgccggc?ggcgtgctgg?133020
gtccagggcc?ggtcgtcgtc?gccgtcgggg?cgggagtaca?gggtcagggc?gcggcggccg?133080
gtctcgtcgg?ggctgccgat?ccagacctgg?acctggacgc?cgccgtcctc?gggcagggcg?133140
agcggggcgg?cgagggtgag?ttcctcgacg?cggtcgcagc?cgacctcgtc?gccggcgcgg?133200
acggcgagtt?cgaggaaggc?ggtgccggcc?agcagcacgg?tgccgcgcac?cgtgtggtcg?133260
gcgagccagg?gatgggtgcg?caccgagaga?cggccggtga?ggagcaggcc?gtcggagttg?133320
gcgagggtga?cggcggcggc?gagcagcggg?tggtgggcgg?cgccgagccc?cgcggaacgc?133380
atgtcgccgg?tgagccccgt?gacgcccttg?ggccagaagc?ggcggtgctg?gaaggcgtag?133440
gtcggcaggt?cggtgtggcc?ggcgccggtc?ccctcgaacc?agcggtccca?gcgcaccggg?133500
acgccgcgca?ggtggagtcc?ggtggcggtc?tcggtgaggg?tggcggcctc?ggggcggtcc?133560
ttgcggagcg?cgggcagcac?ggcggcgcgc?tcgtgcccgg?cggcgtccag?gacggtccgg?133620
gtgagggcgg?cgagcgtggc?gtcggggccc?agttcgagga?agagccccgt?gccgtgtccg?133680
gcgagccagg?agactccgtc?ggcgaagcgc?acggcgtggc?ggacgtgatc?ggtccagtag?133740
ccggcggagg?tgagctgctc?gacggtggcg?ggggcgccgg?tgaggttgga?gacgaccggg?133800
acggtggggg?cctgcgggga?gagtccggcg?acgaccgcgc?ggaactcctc?cagcatcggg?133860
tccatgagcg?gtgagtggaa?cgcgtgggag?acccgcagcc?tgcgggtgcg?gcgcccgagg?133920
gccgcgacgc?gggcggcgat?ggactcgacg?gcgtcctcgg?ctccggagac?gacgaccgcg?133980
gccgggccgt?tgacggcggc?gacggagacc?tgtccggcgt?gttcggcgac?gagcggcgcg?134040
acctcgtcct?cggtggcttc?cagggagacc?atggcgccgc?cctcgtccag?cgcctgcatg?134100
aggcggccac?gggcggtgac?cagggtgcag?gcgtcggcga?gggtgaacac?cccggcgacg?134160
tgggcggcgg?ctatctcgcc?gacggagtgg?ccggtgaggt?ggtcgggggt?gacgccccag?134220
gactcgacga?gccggtacag?ggccacttcg?agggcgaaca?gggcgggctg?cgcgtactcg?134280
gtgcggtcga?ggagcgcggc?ctcctcgctg?ccctcctcgg?cgaggatcag?gggcttcagc?134340
gggcggtcga?gccccgcgtc?gaggtgctcc?aggatctcgt?cgagggcgcg?ggcgaagacg?134400
gggaagcggg?cgtgaaggtc?gcggcccatg?ccgggacgct?gggagccctg?gcccgagaag?134460
agcacggcga?gcttggtacg?gccacgcagc?tggtgggtgg?tgagacccgg?ggcgtccgca?134520
ccggcggcga?gcgcggtgag?cacggcgacg?gcggtgtccc?ggtcggcggt?ggtgaaggcc?134580
gcgcggtgct?ccagggcgga?gcgggtggtg?gcgagcgcgt?gggagacgtc?cagggcggac?134640
ggcgtgggcc?gggcggcgag?gtggtcgagc?agccgggcgg?cctgggcgcg?cagggcctcg?134700
ggggtacggc?cggagagcag?ccagggcagc?gccccggcgt?cgacggccgg?ggcggcctcg?134760
ccgtcggcgg?ccggctcctg?gggagcctcc?tcgatgatgg?tgtgcgcgtt?ggtgccggag?134820
aggccgaagg?aggagatgcc?cgcgcgacgc?ggcgcgttct?cgcgggccgg?ccagggggcg?134880
ggctccgtca?gcaggcggac?ggagccctcg?ctccagtcga?cgtgggtgga?gggctggtcg?134940
acgtggaggg?tgcgcggcag?caggccgtgg?cgcatcgcca?tgaccatctt?gatgacgccc?135000
gcgacacccg?ccgcggcctg?ggtgtggctg?atgttggact?tgaccgagcc?gagcagcaac?135060
gggctgtcgg?cctcgcggcc?ctggccgtag?gtggccagca?gcgcctgggc?ctcgacgggg?135120
tcgccgagga?ccgtgccggt?gccgtgtgcc?tcgacggcgt?cgacgtcggc?ggcggtgagc?135180
cgggcgttga?ccagggcgga?ctcgatgacg?cgctgctggg?aggggccgtt?gggggcggtc?135240
aggccgttgg?aggcaccgtc?ctggttgacg?gcggaccccc?ggaccaccgc?gaggacgcgg?135300
tggccgttgc?ggcgggcctc?ggagagccgc?tccaggacga?ggacgccgac?accctcggac?135360
cagccggtgc?cgttggcggc?gtcggcgaag?gaccggcagc?gcccgtcggc?ggcgaggccg?135420
ccctggcggg?cgaactcgac?gaaggtggtg?gggctggcca?tgacggtgac?accggcggcc?135480
agggccaggg?agcactcccc?cgcgcgcagc?gactgggcgg?ccaggtgcag?ggccaccagg?135540
gaggaggagc?aggcggtgtc?gacggtcacg?gccggtccga?cggcaccgaa?gaagtaggag?135600
agccgcccgg?agaggatgct?ggtggcgttg?ccggtgagct?ggaagccctg?gacgtcgtcg?135660
tcggggccga?cccggtagtc?ctggggcatg?gcgccgacga?acatgccggt?gcggctgccg?135720
cgtacgcccg?cggggtcgat?accggcccgt?tcgaaggcct?cccagccggt?ctccaggagc?135780
aggcgctgct?gcgggtccat?ggacagcgcc?tcgcggggcg?agatgccgaa?gaagtccggg?135840
tcgaaggcgg?gcgcgtcgtg?caggaagccg?ccggcgaagt?cggcggggcc?ctcgccgagc?135900
gcggcctccc?agccacggtc?ctcgggcatg?ccggtgatgc?cgtcctcgcc?ggcgaccagc?135960
atcttccaca?ggtcctcggg?gctgctcacc?ccgccggggt?agcggcagct?catgccgacg?136020
atcgcgatgg?gctcggtggc?cgccgcctcc?agctcggtca?cccgctgccg?ggagcgcttc?136080
agatcggcgc?tcgcccgctt?caggtagtcc?cggagcttct?gttccttgtc?catatcaacg?136140
caacccatct?ggatgaagac?cggcggacgg?ctggcggtcc?ggcgtggaca?ccgggtgccc?136200
gggacggccg?gagggggccg?ggccgggcgg?ggtgtcccga?ggaggggaaa?gggcgggggg?136260
cggggcctgg?gcggcctgcc?gggcgcggtg?tctcacgtgc?ctgcgggggc?ggcccgggcg?136320
ccgctccgcg?gaccggagga?ccagggcggc?tctccggcac?gcggacgggc?gggcggcgcc?136380
accgccgctc?cccgggagca?cacgccgagc?acgcgtgccg?tgccctcagt?tccgctgacc?136440
atggggccca?gtctgcggcg?ggtggggctt?tggaaatccc?tagtgtgtgc?gcgggtgacg?136500
gggccgcagg?ttcgcaggtc?acgagcggcc?ccgccccggt?ccccggacgg?agccggccta?136560
ccagctgccg?gtggccagga?gctggctgta?gtcccgctcc?cgcgatgcct?ggcgcaggtc?136620
ggactcgacc?atcatgcgca?tcagctgctc?gaagtcgacc?tcgggctccc?agcccagttc?136680
gcgccgggcg?ttgcccgagt?cggcgcagag?ggtctcgacc?tcggcggggc?gcaccaggcc?136740
ggggtcgacg?acgacgtgct?cctgccagtc?gaggccgacg?tgctcgaagg?cgatccgggc?136800
cgcgtcgcgg?acctggtgca?tggctccggt?ccccaccacg?tagtcaccgg?cctgctcctg?136860
ctggagcatc?aggtgcatgg?cgcggacgta?gtcacccgcg?aagccccagt?cgcgctcggc?136920
gtcgaggttg?ccgaggtgca?gcttgtccat?ctggcccagt?ttgatctggg?cgacggccag?136980
cgagatcttg?cgggtgacga?actcggcgcc?acggcgcggc?gactcgtggt?tgaacaggat?137040
cccggagacc?ccgtacatcc?cgtacgactc?gcggtagttc?tgggtgatgt?agtggccgaa?137100
ggccttggcc?acgccgtacg?ggctgcgggg?gtggaaggag?gtggtctccc?gctgcgggct?137160
ctccgccacc?ttgccgtaca?tctcggagga?ggacgcctgg?tagaagcgga?tctggccgcg?137220
gggcgagccg?ccggaggact?tggtgaggcc?ggagacgatg?cggaccgcct?ccagcatgcg?137280
cagcacgccg?gtgccgttga?cctccgtgac?cagttcgggc?tgttgccagg?acatcggcac?137340
gaaggagatg?gcgcccaggt?tgtagacctc?gtcgggctgg?accaggtcga?ccgccgagac?137400
caggctgccc?tggtccatga?ggtcgccgtc?cacgaaggac?agctccggga?tcagcttggc?137460
gatccggtcc?ttgcgggggt?tggcctgacc?ccggcagagc?ccccagacct?ggtacccctg?137520
gtcgaggagg?tgttcggcca?ggtacgaacc?gtcctgtccg?gtgattccgg?tgatgagtgc?137580
acgcttggac?atctttcctc?tttccaccgc?cacggtgagg?accggtcggg?cgggtgtccg?137640
cgccggcggg?ggcggactga?tggaccccca?tgcgtactga?cacgctccgg?cggagggcag?137700
agccttgccc?ccctccggag?cacgagacgc?acggctgcgc?tcacgagccg?tcctcgtcgc?137760
ggacatgcaa?gcacgggcag?agctaaggga?tttgcgagtc?ttcacggccg?cgtcccgcgc?137820
acgggccgac?ggaaatcacc?gcataacgcg?gcacacccgc?cgggttcagc?cggcgccgcc?137880
ggcctggcgg?cgggagcgct?ggtccttctc?gtgggcgagc?agtttcgcgt?cgccctggag?137940
gcgggcggcg?cccttgcgga?gtgcggggag?cagctgcatg?agggcgtcgc?ccgggcagtt?138000
ggtctcgtag?gcgtcgatgt?ggccgaagac?ggccggcatg?gtgacggtgg?tgttcttggc?138060
gaaccggctg?tcgctgttcc?tggagagcag?gtgggtgttg?gcgaccgggt?cggcctgggt?138120
gagggccagc?ttccaggcga?tgagtttctc?gatggagcgg?cgcatcggct?cgggcacggg?138180
ggtgccggcc?gtgaaggtgc?cga?????????????????????????????????????????138203
<210>2
<211>1743
<212>PRT
＜213〉streptomycete FR-008
<400>2
Met?Val?Pro?Val?His?Ala?His?Asp?Tyr?Val?Thr?Asp?Pro?Pro?Ser?Thr
1???????????????5???????????????????10??????????????????15
Thr?Gly?Arg?Thr?Leu?Asp?Gly?Leu?Thr?Leu?Pro?Arg?Val?Phe?Ala?Asp
20??????????????????25??????????????????30
Ala?Val?His?Arg?Gly?Gly?Asp?Ala?Val?Ala?Leu?Val?Asp?Gly?Glu?Tyr
35??????????????????40??????????????????45
Ala?Leu?Thr?Trp?Ser?Ala?Trp?Arg?Thr?Ala?Val?Asp?Ala?Leu?Ala?Arg
50??????????????????55??????????????????60
Gly?Leu?Gln?Glu?Ser?Gly?Val?Val?Ser?Gly?Asp?Val?Val?Ala?Leu?His
65??????????????????70??????????????????75??????????????????80
Leu?Pro?Asn?Ser?Trp?Glu?Tyr?Leu?Thr?Leu?His?Leu?Ala?Ala?Ala?Ser
85??????????????????90??????????????????95
Val?Gly?Ala?Val?Thr?Met?Pro?Val?His?Gln?Gly?Asn?Ala?Pro?Ser?Asp
100?????????????????105?????????????????110
Val?Arg?Ala?Leu?Leu?Glu?Arg?Val?Arg?Pro?Ala?Ala?Val?Val?Leu?Pro
115?????????????????120?????????????????125
Ala?Arg?Thr?Gln?Glu?Gly?Gly?Gly?Pro?Leu?Thr?Gly?Thr?Ala?Leu?Arg
130?????????????????135?????????????????140
Glu?Val?Leu?Pro?Glu?Leu?Arg?Ala?Val?Leu?Val?Thr?Gly?Asp?Ala?Ala
145?????????????????150?????????????????155?????????????????160
Gly?Glu?Gly?Thr?Glu?Thr?Val?Thr?Glu?Met?Leu?Glu?Arg?Trp?Ser?Gly
165?????????????????170?????????????????175
Glu?Asp?Pro?Leu?Pro?Val?Glu?Val?Arg?Pro?Asp?Ser?Pro?Phe?Leu?Leu
180?????????????????185?????????????????190
Leu?Pro?Ser?Ser?Gly?Thr?Thr?Ser?Ala?Arg?Pro?Lys?Ile?Cys?Leu?His
195?????????????????200?????????????????205
Ser?His?Glu?Gly?Leu?Leu?Thr?Asn?Ser?Arg?Ala?Ala?Thr?Glu?Asp?Thr
210?????????????????215?????????????????220
Ala?Asp?Ala?Tyr?Ala?Gly?Thr?Leu?Ile?Thr?Ala?Cys?Pro?Leu?Thr?His
225?????????????????230?????????????????235?????????????????240
Cys?Phe?Gly?Leu?Gln?Ser?Ala?Tyr?Ser?Ala?Leu?Phe?Arg?Ala?Gly?Arg
245?????????????????250?????????????????255
Gln?Val?Leu?Leu?Ser?Gly?Trp?Asp?Val?Gly?Arg?Phe?Leu?Glu?Leu?Ala
260?????????????????265?????????????????270
Arg?Arg?Glu?Arg?Pro?Ser?Val?Val?Val?Ala?Val?Pro?Ala?Gln?Leu?His
275?????????????????280?????????????????285
Asp?Leu?Val?Thr?Arg?Val?Arg?Glu?Asp?Ala?Asp?Gly?Pro?Gly?Phe?Arg
290?????????????????295?????????????????300
Pro?Gly?Arg?Ile?Leu?Thr?Ala?Gly?Ala?Ala?Leu?Pro?Pro?Ala?Leu?Val
305?????????????????310?????????????????315?????????????????320
Arg?Asp?Val?Arg?Glu?Ala?Leu?Asp?Thr?Thr?Leu?Val?Val?Val?Trp?Gly
325?????????????????330?????????????????335
Met?Ser?Glu?Ala?Gly?Asn?Gly?Thr?Ser?Ser?Leu?Ser?Ala?Asp?Ala?Pro
340?????????????????345?????????????????350
Glu?Val?Val?Ser?Arg?Ser?Val?Gly?Arg?Pro?Thr?Arg?Asp?Ala?Glu?Met
355?????????????????360?????????????????365
Arg?Val?Val?Asp?Glu?Asp?Gly?Ala?Pro?Cys?Pro?Pro?Gly?Gln?Pro?Gly
370?????????????????375?????????????????380
Glu?Leu?Tyr?Tyr?Arg?Ser?Pro?Ser?Met?Phe?Arg?Gly?Tyr?Phe?Gly?Glu
385?????????????????390?????????????????395?????????????????400
Pro?Glu?Leu?Thr?Arg?Ser?Val?Val?Ser?Glu?Asp?Gly?Trp?Leu?Arg?Thr
405?????????????????410?????????????????415
Gly?Asp?Leu?Ala?Ser?Ile?Gly?Glu?Asp?Gly?Leu?Val?Thr?Phe?His?Gly
420?????????????????425?????????????????430
Arg?Ser?Ala?Glu?Leu?Ile?Asn?Val?Gly?Gly?Arg?Lys?Phe?Asn?Ala?Val
435?????????????????440?????????????????445
Glu?Ile?Gln?Ala?Leu?Leu?Ala?Asp?Leu?Pro?Asp?Ile?Gly?Pro?Leu?Ala
450?????????????????455?????????????????460
Val?Val?Ala?Ala?Pro?Asp?Pro?Arg?Leu?Gly?Glu?Tyr?Pro?Val?Leu?Val
465?????????????????470?????????????????475?????????????????480
Val?Thr?Glu?Arg?Pro?Ala?Ala?Ala?Pro?Ala?Asp?Gly?Thr?Ala?Pro?Arg
485?????????????????490?????????????????495
Pro?Arg?Gly?Thr?Val?Gly?Leu?Asp?Glu?Val?Thr?Ala?His?Leu?Arg?Gly
500?????????????????505?????????????????510
Leu?Gly?Thr?Ala?Glu?Tyr?Lys?Ile?Pro?Leu?Glu?Leu?Val?Ala?Leu?Pro
515?????????????????520?????????????????525
Glu?Leu?Pro?Arg?Thr?Pro?Ala?Gly?Lys?Ile?Asn?Arg?Arg?Ala?Leu?Glu
530?????????????????535?????????????????540
Gln?Tyr?Leu?Ala?Asp?Ala?Ala?Glu?Arg?Thr?Ala?Val?Thr?Pro?Ala?Glu
545?????????????????550?????????????????555?????????????????560
Ala?Pro?Arg?Pro?Gly?Leu?Arg?Thr?Ala?Leu?Glu?Leu?Val?Val?Thr?Ala
565?????????????????570?????????????????575
Val?Ala?Glu?Val?Leu?Ala?Ala?Val?Pro?Gly?Glu?Asp?Gly?Ala?Arg?Pro
580?????????????????585?????????????????590
Ala?Ala?Ala?Gly?Pro?Ile?Gly?Pro?Asp?Thr?Thr?Phe?Arg?Ala?His?Gly
595?????????????????600?????????????????605
Leu?Asp?Ser?Val?Ala?Ser?Val?Arg?Leu?Arg?Asn?Ala?Leu?Ala?Glu?Ala
610?????????????????615?????????????????620
Thr?Gly?Leu?Thr?Leu?Pro?Ala?Gly?Leu?Ala?Phe?Asp?Phe?Pro?Thr?Pro
625?????????????????630?????????????????635?????????????????640
Ala?Ala?Leu?Ala?Arg?Glu?Leu?Ala?Gly?Leu?Ser?Ser?Pro?Ala?Ala?Glu
645?????????????????650?????????????????655
Glu?Ser?Pro?Gly?Ala?Ser?Ala?His?Glu?Asp?Glu?Pro?Val?Ala?Ile?Val
660?????????????????665?????????????????670
Ser?Met?Ala?Cys?Arg?Leu?Pro?Gly?Gly?Ala?Thr?Ser?Pro?Glu?Ala?Leu
675?????????????????680?????????????????685
Trp?Glu?Leu?Leu?Arg?Asp?Gly?Val?Asp?Ala?Val?Ser?Gly?Phe?Pro?Glu
690?????????????????695?????????????????700
Asp?Arg?Gly?Trp?Asp?Leu?Asp?Ala?Leu?Phe?Gly?Asp?Asp?Pro?Asp?Ala
705?????????????????710?????????????????715?????????????????720
Pro?Gly?Thr?Ser?Val?Ala?Arg?Glu?Gly?Gly?Phe?Leu?Arg?Asp?Ala?Ala
725?????????????????730?????????????????735
His?Phe?Asp?Ala?Gly?Phe?Phe?Gly?Met?Ser?Ala?Arg?Glu?Ala?Leu?Ala
740?????????????????745?????????????????750
Thr?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu?Thr?Ala?Trp?Glu?Ala?Val
755?????????????????760?????????????????765
Glu?Arg?Ala?Gly?Ile?Ala?Pro?Arg?Thr?Leu?Arg?Gly?Ser?Arg?Thr?Gly
770?????????????????775?????????????????780
Val?Phe?Thr?Gly?Ala?Met?Tyr?His?Asp?Tyr?Ala?Ala?Gly?Ala?Ser?Asp
785?????????????????790?????????????????795?????????????????800
Pro?Ala?Gly?Glu?Leu?Glu?Ser?Leu?Leu?Pro?Val?Gly?Thr?Ala?Gly?Gly
805?????????????????810?????????????????815
Ala?Leu?Ser?Gly?Arg?Ile?Ala?Tyr?Thr?Leu?Gly?Leu?Ser?Gly?Pro?Ala
820?????????????????825?????????????????830
Leu?Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His?Leu
835?????????????????840?????????????????845
Ala?Cys?Arg?Ser?Leu?Arg?Ser?Gly?Glu?Ser?Asp?Leu?Ala?Leu?Ala?Gly
850?????????????????855?????????????????860
Gly?Val?Ala?Val?Met?Ala?Thr?Pro?Ala?Ala?Phe?Val?Gly?Phe?Ser?Arg
865?????????????????870?????????????????875?????????????????880
Leu?Arg?Gly?Leu?Ser?Pro?Asp?Gly?Arg?Cys?Lys?Ser?Phe?Gly?Glu?Gly
885?????????????????890?????????????????895
Ala?Asp?Gly?Ala?Ala?Trp?Ser?Glu?Gly?Ala?Gly?Leu?Leu?Met?Leu?Glu
900?????????????????905?????????????????910
Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Pro?Val?Leu?Ala?Val?Ile
915?????????????????920?????????????????925
Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala
930?????????????????935?????????????????940
Pro?His?Gly?Pro?Ala?Gln?Arg?Arg?Val?Val?Arg?Gln?Ala?Leu?Ala?Asp
945?????????????????950?????????????????955?????????????????960
Ala?Gly?Val?Arg?Ala?Ala?Glu?Val?Asp?Val?Val?Glu?Ala?His?Gly?Thr
965?????????????????970?????????????????975
Gly?Thr?Ala?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Glu?Ala?Leu?Leu?Asp?Thr
980?????????????????985?????????????????990
Tyr?Gly?Arg?Asp?Arg?Pro?Glu?Gly?Arg?Pro?Leu?Trp?Leu?Gly?Ser?Val
995?????????????????1000????????????????1005
Lys?Ser?Asn?Leu?Gly?His?Thr?Gln?Ala?Ala?Ala?Gly?Ala?Ala?Ala
1010????????????????1015????????????????1020
Val?Ile?Lys?Met?Val?Leu?Ala?Leu?Arg?His?Asp?Leu?Leu?Pro?Ala
1025????????????????1030????????????????1035
Thr?Leu?His?Ala?Asp?Thr?Pro?Thr?Ser?Arg?Val?Asp?Trp?Ser?Pro
1040????????????????1045????????????????1050
Gly?Thr?Val?Gln?Leu?Leu?Thr?Arg?Ala?Arg?Asp?Trp?Pro?Arg?Glu
1055????????????????1060????????????????1065
Glu?Gly?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ser?Phe?Gly?Ile?Ser
1070????????????????1075????????????????1080
Gly?Thr?Asn?Ala?His?Leu?Val?Leu?Glu?Glu?Ala?Pro?Val?Pro?Ala
1085????????????????1090????????????????1095
Ala?Gly?Thr?Glu?Arg?Ser?Ala?Asp?Ala?Gly?Ala?Ala?Gly?Leu?Arg
1100????????????????1105????????????????1110
Ala?Ala?Val?Pro?Trp?Leu?Val?Ser?Ala?Lys?Asp?Ala?Asp?Ala?Leu
1115????????????????1120????????????????1125
Arg?Gly?Gln?Ala?Arg?Arg?Leu?Ala?Ala?His?Ala?Ala?Ala?His?Pro
1130????????????????1135????????????????1140
Glu?Val?Ser?Ala?Arg?Asp?Leu?Ala?Tyr?Ser?Leu?Leu?Thr?Thr?Arg
1145????????????????1150????????????????1155
Ala?Leu?His?Pro?Arg?Thr?Ala?Leu?Leu?Thr?Gly?Gly?Asp?Arg?Asp
1160????????????????1165????????????????1170
Ala?Leu?Val?Ala?Ser?Ala?Asp?Ala?Phe?Ala?Arg?Gly?Glu?Ala?Pro
1175
Gly?Ser?Ile?Val?Arg?Gly?Pro?Leu?Gly?Pro?Ala?Pro?Gly?Thr?Ala
1190????????????????1195????????????????1200
Phe?Val?Leu?Thr?Gly?Gln?Gly?Ser?Gln?Arg?Leu?Gly?Met?Gly?Arg
1205????????????????1210????????????????1215
Gly?Leu?Ala?Ala?Ala?Phe?Pro?Val?Phe?Asp?Asp?Ala?Leu?Arg?Glu
1220????????????????1225????????????????1230
Val?Cys?Ala?Leu?Leu?Asp?Pro?Leu?Leu?Glu?Arg?Pro?Leu?Thr?Glu
1235????????????????1240????????????????1245
Val?Met?Trp?Ala?Ala?Pro?Asp?Ser?Asp?Glu?Ala?Gly?Leu?Leu?Gly
1250????????????????1255????????????????1260
Gly?Thr?Gly?Tyr?Ala?Gln?Pro?Ala?Leu?Phe?Ala?Phe?Glu?Val?Ala
1265????????????????1270????????????????1275
Leu?Tyr?Arg?Leu?Leu?Glu?Ser?Trp?Gly?Ile?Val?Pro?Asp?Arg?Leu
1280????????????????1285????????????????1290
Val?Gly?His?Ser?Val?Gly?Glu?Ile?Ala?Ala?Ala?His?Val?Ala?Gly
1295????????????????1300????????????????1305
Val?Leu?Ser?Leu?Pro?Asp?Ala?Cys?Ala?Leu?Val?Ala?Ala?Arg?Gly
1310????????????????1315????????????????1320
Arg?Leu?Met?Gln?Ala?Leu?Pro?Pro?Gly?Gly?Ala?Met?Ala?Ala?Val
1325????????????????1330????????????????1335
Arg?Cys?Ser?Glu?Ala?Glu?Ile?Leu?Pro?Leu?Leu?Ala?Gly?Arg?Thr
1340????????????????1345????????????????1350
Ala?Gly?Ala?Thr?Val?Ala?Ala?Val?Asn?Gly?Pro?Arg?Ser?Val?Val
1355????????????????1360????????????????1365
Leu?Ser?Gly?Thr?Glu?Glu?Ala?Val?Ala?Glu?Val?Val?Thr?Glu?Val
1370????????????????1375????????????????1380
Ser?Ala?Ala?Gly?His?Lys?Thr?Arg?Arg?Leu?Met?Val?Ser?His?Ala
1385????????????????1390????????????????1395
Phe?His?Ser?Pro?Leu?Met?Glu?Pro?Met?Leu?Ala?Glu?Phe?Arg?Ala
1400????????????????1405????????????????1410
Thr?Val?Ala?Gly?Leu?Ser?Phe?Ala?Ala?Pro?Gln?Val?Pro?Leu?Val
1415????????????????1420????????????????1425
Ser?Gly?Val?Thr?Gly?Arg?Pro?Leu?Thr?Ala?Glu?Glu?Ala?Arg?Asp
1430????????????????1435????????????????1440
Pro?Asp?His?Trp?Val?Arg?His?Ala?Arg?Asp?Thr?Val?Arg?Phe?Ala
1445????????????????1450????????????????1455
Asp?Ala?Ile?Ser?His?Leu?Ala?Gly?Glu?His?Thr?Glu?Ile?Tyr?Val
1460????????????????1465????????????????1470
Glu?Leu?Gly?Pro?Glu?Ala?Ala?Leu?Thr?Pro?Met?Val?Glu?Glu?Cys
1475????????????????1480????????????????1485
Leu?Gly?Glu?Pro?Glu?Ser?Gly?Asp?Gly?Pro?Ala?Val?Glu?Pro?Val
1490????????????????1495????????????????1500
Val?Arg?Gly?Asp?Val?Asp?Glu?Glu?Arg?Ala?Ala?Leu?Ala?Ala?Ala
1505????????????????1510????????????????1515
Val?Arg?Leu?His?Ala?Leu?Gly?Leu?Asp?Val?Gln?Trp?Arg?Ala?Val
1520????????????????1525????????????????1530
Leu?Pro?Glu?Ala?Arg?Ala?Val?Pro?Leu?Pro?Thr?Tyr?Ala?Phe?Gln
1535????????????????1540????????????????1545
His?Glu?Ala?Tyr?Trp?Leu?Ala?Thr?Ser?Gly?Ser?Val?Val?Ala?Gly
1550????????????????1555????????????????1560
Leu?Ser?Leu?Pro?Gly?Gly?Arg?Ala?Ala?Asp?Thr?Val?Pro?Asp?Leu
1565????????????????1570????????????????1575
Ala?Gly?Arg?Leu?Ala?Gly?Leu?Ser?Gly?Gly?Glu?Ala?Glu?Ala?Leu
1580????????????????1585????????????????1590
Val?Thr?Glu?Leu?Val?Arg?Thr?Glu?Leu?Ala?Ala?Val?Thr?Gly?Gly
1595????????????????1600????????????????1605
Glu?Ile?Ser?Ala?Ala?Gly?Ala?Gly?Thr?Ala?Phe?Thr?Glu?Leu?Gly
1610????????????????1615????????????????1620
Val?Thr?Ser?Val?Thr?Ala?Val?Glu?Leu?Arg?Asn?Arg?Leu?Thr?Ala
1625????????????????1630????????????????1635
Val?Thr?Gly?Val?Arg?Leu?Pro?Pro?Thr?Leu?Ile?Phe?Asp?His?Pro
1640????????????????1645????????????????1650
Thr?Pro?Thr?Ala?Val?Ala?Arg?Leu?Ile?Gly?Glu?Thr?Val?Arg?Gly
1655????????????????1660????????????????1665
Ser?Ser?Val?Pro?Gly?Arg?Arg?Asp?Ala?Val?Ser?Leu?Val?Asp?Glu
1670????????????????1675????????????????1680
Leu?Glu?Ala?Leu?Leu?Val?Ser?Gly?Ala?Glu?Val?Asp?Ser?Asp?Thr
1685????????????????1690????????????????1695
Ala?Ala?Arg?Leu?Arg?Ser?Leu?Ala?Gly?Arg?Trp?Ala?Pro?Ser?Ala
1700????????????????1705????????????????1710
Thr?Gly?Thr?Ala?Ala?Asp?Ala?Asn?Gly?Pro?Leu?Asp?Leu?Asp?Asp
1715????????????????1720????????????????1725
Ala?Ser?Asp?Glu?Glu?Leu?Phe?Arg?Leu?Met?Asp?Gly?Gly?Ala?Pro
1730????????????????1735????????????????1740
<210>3
<211>10625
<212>PRT
＜213〉streptomycete FR-008
<400>3
Met?Ala?Ser?Ser?Glu?Ala?Lys?Leu?Arg?Asp?Tyr?Leu?Lys?Lys?Val?Thr
1???????????????5???????????????????10??????????????????15
Thr?Asp?Leu?Arg?Arg?Thr?Arg?Gln?Arg?Leu?Glu?Thr?Val?Glu?Ala?Arg
20??????????????????25??????????????????30
Glu?Ser?Glu?Pro?Ile?Ala?Val?Ile?Gly?Met?Ala?Cys?Arg?Phe?Pro?Gly
35??????????????????40??????????????????45
Gly?Val?Arg?Ser?Pro?Glu?Asp?Leu?Trp?Gln?Leu?Val?Ala?Asp?Gly?Thr
50??????????????????55??????????????????60
Asp?Ala?Ile?Gly?Pro?Leu?Pro?Ala?Asp?Arg?Gly?Trp?Asp?Leu?Asp?Gly
65??????????????????70??????????????????75??????????????????80
Leu?Tyr?Asp?Pro?Asp?Pro?Gly?Thr?Pro?Gly?Lys?Ser?Tyr?Val?Arg?Glu
85??????????????????90??????????????????95
Gly?Gly?Phe?Leu?Glu?Gly?Ala?Ala?Asp?Phe?Asp?Ala?Asp?Leu?Phe?Gly
100?????????????????105?????????????????110
Ile?Ala?Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu
115?????????????????120?????????????????125
Leu?Glu?Thr?Ala?Trp?Glu?Ala?Val?Glu?Arg?Ala?Arg?Ile?Ser?Pro?Ala
130?????????????????135?????????????????140
Ser?Leu?Arg?Asn?Thr?Asp?Thr?Gly?Val?Phe?Val?Gly?Gly?Ala?Asp?Thr
145?????????????????150?????????????????155?????????????????160
Asn?Tyr?Gly?Ser?Leu?Ala?Arg?Thr?Ala?Glu?Glu?Thr?Glu?Gly?His?Asn
165?????????????????170?????????????????175
Leu?Thr?Gly?Gly?Ala?Met?Ser?Val?Leu?Ser?Gly?Arg?Ile?Ser?Tyr?Thr
180?????????????????185?????????????????190
Leu?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser
195?????????????????200?????????????????205
Ser?Leu?Val?Ala?Leu?His?Leu?Ala?Val?Arg?Ala?Leu?Arg?Ala?Gly?Glu
210?????????????????215?????????????????220
Cys?Ser?Leu?Ala?Leu?Ala?Gly?Gly?Val?Ala?Met?Met?Pro?Thr?Thr?Glu
225?????????????????230?????????????????235?????????????????240
Leu?Phe?Thr?Glu?Phe?Ser?Arg?Gln?Arg?Gly?Leu?Ala?Thr?Asp?Gly?Arg
245?????????????????250?????????????????255
Cys?Lys?Pro?Phe?Ala?Glu?Ala?Ala?Asp?Gly?Thr?Ser?Trp?Gly?Glu?Gly
260?????????????????265?????????????????270
Val?Gly?Val?Leu?Leu?Val?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly
275?????????????????280?????????????????285
His?Pro?Val?Leu?Ala?Val?Val?Arg?Gly?Thr?Ala?Val?Asn?Gln?Asp?Gly
290?????????????????295?????????????????300
Ala?Ser?Ser?Arg?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Arg?Arg?Val
305?????????????????310?????????????????315?????????????????320
Ile?Glu?Ala?Ala?Leu?Ala?Asp?Ala?Arg?Leu?Ala?Ala?Asp?Gln?Val?Asp
325?????????????????330?????????????????335
Ala?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp?Pro?Ile?Glu
340?????????????????345?????????????????350
Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Asn?Arg?Pro?Glu?Asp?Arg
355?????????????????360?????????????????365
Pro?Leu?Arg?Leu?Gly?Gly?Ile?Lys?Ser?Asn?Ile?Gly?His?Ala?Gln?Ala
370?????????????????375?????????????????380
Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Val?Met?Ala?Ile?Arg?His
385?????????????????390?????????????????395?????????????????400
Gly?Leu?Leu?Pro?Ala?Thr?Leu?His?Val?Asp?Thr?Pro?Thr?Pro?His?Val
405?????????????????410?????????????????415
Asp?Trp?Thr?Ala?Gly?Ala?Val?Glu?Leu?Leu?Thr?Glu?Ala?Val?Asp?Trp
420?????????????????425?????????????????430
Pro?Asp?Ala?Asp?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ala?Phe?Gly?Ile
435?????????????????440?????????????????445
Ser?Gly?Thr?Asn?Ala?His?Val?Leu?Leu?Glu?Gln?Ala?Thr?Pro?Glu?Pro
450?????????????????455?????????????????460
Ala?Gly?Ala?Glu?Asp?Thr?Pro?Gln?Asp?Ala?Thr?Pro?Ala?Glu?Pro?Val
465?????????????????470?????????????????475?????????????????480
Thr?Ala?Thr?Asp?Pro?Ala?Val?Thr?Pro?Trp?Leu?Leu?Ser?Ala?Arg?Ser
485?????????????????490?????????????????495
Gln?Thr?Ala?Leu?Arg?Ala?Gln?Ala?Ala?Arg?Leu?Leu?Ala?His?Leu?Thr
500?????????????????505?????????????????510
Asp?His?Thr?Gly?Pro?Glu?Ser?Pro?Arg?Pro?Ala?Asp?Ile?Ala?Leu?Ser
515?????????????????520?????????????????525
Leu?Ala?Thr?Ser?Arg?Ala?Pro?Leu?Pro?His?Arg?Ala?Val?Val?Leu?Ala
530?????????????????535?????????????????540
Thr?Asp?Pro?Gly?Thr?Thr?Glu?Ala?Ala?Leu?Thr?Ser?Leu?Ala?Ala?Asp
545?????????????????550?????????????????555?????????????????560
Glu?Pro?His?Pro?Ala?Val?Leu?Glu?Asp?Ala?Val?Arg?Ser?Ala?Ser?Thr
565?????????????????570?????????????????575
Ala?Phe?Leu?Phe?Ser?Gly?Gln?Gly?Ser?Gln?Arg?Leu?Gly?Met?Gly?Arg
580?????????????????585?????????????????590
Gly?Leu?Tyr?Glu?Arg?Phe?Pro?Val?Phe?Ala?Glu?Ala?Phe?Asp?Ala?Val
595?????????????????600?????????????????605
Cys?Ala?Gly?Leu?Asp?Glu?His?Leu?Glu?Arg?Pro?Leu?Arg?Glu?Val?Val
610?????????????????615?????????????????620
Trp?Gly?Asp?Asp?Thr?Ser?Val?Leu?Asp?Gly?Thr?Ala?Tyr?Ala?Gln?Ala
625?????????????????630?????????????????635?????????????????640
Gly?Leu?Phe?Ala?Val?Glu?Val?Ala?Leu?Phe?Arg?Leu?Val?Glu?Ser?Trp
645?????????????????650?????????????????655
Gly?Val?Arg?Pro?Glu?Phe?Val?Ala?Gly?His?Ser?Ile?Gly?Glu?Val?Ala
660?????????????????665?????????????????670
Ala?Ala?His?Val?Ala?Gly?Val?Phe?Ser?Leu?Ala?Asp?Ala?Cys?Val?Leu
675?????????????????680?????????????????685
Val?Ala?Ala?Arg?Gly?Arg?Leu?Met?Gln?Ala?Leu?Pro?Glu?Gly?Gly?Ala
690?????????????????695?????????????????700
Met?Val?Ala?Val?Glu?Ala?Ser?Glu?Ala?Glu?Val?Leu?Pro?Arg?Leu?Glu
705?????????????????710?????????????????715?????????????????720
Ser?Val?Glu?Gly?Val?Ser?Val?Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val
725?????????????????730?????????????????735
Val?Val?Ser?Gly?Ala?Glu?Asp?Ala?Val?Glu?Ala?Val?Ala?Glu?Val?Phe
740?????????????????745?????????????????750
Arg?Glu?Gln?Gly?Arg?Arg?Val?Ser?Arg?Leu?Arg?Val?Ser?His?Ala?Phe
755?????????????????760?????????????????765
His?Ser?Pro?Leu?Met?Glu?Pro?Met?Leu?Gly?Asp?Phe?Arg?Glu?Ala?Leu
770?????????????????775?????????????????780
Ala?Gly?Leu?Ser?Tyr?Ala?Glu?Pro?Ser?Leu?Pro?Val?Val?Ser?Asn?Val
785?????????????????790?????????????????795?????????????????800
Ser?Gly?Arg?Ile?Ala?Glu?Pro?Gly?Glu?Leu?Thr?Thr?Pro?Asp?Tyr?Trp
805?????????????????810?????????????????815
Val?Arg?His?Val?Arg?Glu?Ala?Val?Arg?Phe?Asp?Asp?Gly?Val?Gln?Ala
820?????????????????825?????????????????830
Leu?Ala?Ala?Glu?Gly?Val?Ala?Arg?Phe?Val?Glu?Leu?Gly?Pro?Asp?Gly
835?????????????????840?????????????????845
Val?Leu?Ser?Gly?Met?Ala?Arg?Val?Ser?Ala?Gly?Glu?Asp?Ala?Val?Leu
850?????????????????855?????????????????860
Val?Pro?Leu?Leu?Arg?Lys?Asp?Arg?Asp?Glu?Glu?Val?Thr?Ala?Leu?Ala
865?????????????????870?????????????????875?????????????????880
Ala?Leu?Gly?Arg?Leu?His?Ala?Thr?Gly?Ala?Pro?Val?Asp?Trp?Thr?Ala
885?????????????????890?????????????????895
Val?Leu?Ala?Gly?Thr?Gly?Ala?Arg?Leu?Val?Asp?Leu?Pro?Thr?Tyr?Ala
900?????????????????905?????????????????910
Phe?Gln?His?Glu?His?Tyr?Trp?Pro?Val?Pro?Ala?Pro?Ala?Pro?Ala?Gly
915?????????????????920?????????????????925
Asp?Val?Glu?Ser?Ala?Gly?Leu?Arg?Ala?Ala?Gly?His?Pro?Leu?Leu?Ser
930?????????????????935?????????????????940
Ala?Ala?Val?Glu?Leu?Ser?Asp?Ser?Gly?Gly?Leu?Leu?Leu?Thr?Thr?Arg
945?????????????????950?????????????????955?????????????????960
Leu?Ser?Leu?Arg?Thr?His?Pro?Trp?Leu?Gly?Glu?His?Val?Val?Met?Gly
965?????????????????970?????????????????975
Asn?Ala?Leu?Leu?Pro?Gly?Thr?Ala?Phe?Val?Glu?Leu?Ala?Val?Arg?Ala
980?????????????????985?????????????????990
Gly?Asp?Glu?Val?Gly?Cys?Asp?Arg?Val?Glu?Glu?Leu?Thr?Leu?Ala?Ala
995?????????????????1000????????????????1005
Pro?Leu?Val?Leu?Pro?Glu?Gln?Gly?Gly?Val?Gln?Leu?His?Leu?His
1010????????????????1015????????????????1020
Val?Gly?Pro?Ala?Asp?Ala?Ala?Gly?Arg?Arg?Val?Leu?Ala?Ala?Arg
1025???????????????1030????????????????1035
Ser?Arg?Ala?Glu?Gly?Ala?Asp?Asp?Gln?Pro?Trp?Thr?Glu?His?Ala
1040????????????????1045????????????????1050
Thr?Gly?Val?Leu?Ala?Pro?Gly?Glu?Arg?Thr?Val?Glu?Phe?Asp?Thr
1055????????????????1060????????????????1065
Ser?Val?Trp?Pro?Pro?Ala?Asp?Ala?Glu?Ser?Leu?Asp?Leu?Thr?Gly
1070????????????????1075????????????????1080
Leu?Tyr?Glu?Arg?Met?Ala?Glu?Gly?Gly?Tyr?Arg?Tyr?Gly?Pro?Leu
1085????????????????1090????????????????1095
Phe?Gln?Gly?Leu?Arg?Ala?Ala?Trp?Arg?Arg?Gly?Asp?Asp?Val?Phe
1100????????????????1105????????????????1110
Ala?Glu?Val?Ala?Leu?Pro?Asp?Ser?Ala?Glu?Arg?Asp?Ala?Thr?Ala
1115????????????????1120????????????????1125
Tyr?Gly?Leu?His?Pro?Ala?Leu?Leu?Asp?Ala?Ser?Leu?His?Val?Ser
1130????????????????1135????????????????1140
Ala?Leu?Gly?Gly?Leu?Ala?His?Gly?Val?Val?Pro?Phe?Ser?Trp?Glu
1145????????????????1150????????????????1155
Gly?Val?Cys?Leu?His?Ala?Thr?Gly?Ala?Arg?Glu?Val?Arg?Val?Arg
1160????????????????1165????????????????1170
Met?Thr?Arg?Thr?Gly?Asp?Glu?Thr?Val?Thr?Val?Ala?Val?Ala?Asp
1175????????????????1180????????????????1185
Pro?Thr?Gly?Ala?Pro?Val?Ala?Ser?Val?Glu?Asn?Leu?Val?Leu?Arg
1190????????????????1195????????????????1200
Arg?Val?Ala?Pro?Asp?Ala?Thr?Gly?Val?Asp?Ala?Leu?Thr?Arg?Asp
1205????????????????1210????????????????1215
Ala?Leu?Phe?Arg?Val?Asp?Trp?Val?Arg?Thr?Glu?Ala?Pro?Gly?Asp
1220????????????????1225????????????????1230
Ala?Ala?Gly?Thr?Gly?Pro?Val?Gly?Val?Leu?Gly?Asp?Ser?Asp?Ala
1235????????????????1240????????????????1245
Ser?Thr?Ala?Leu?Ala?Gly?Val?Leu?Arg?Ala?Asp?Gly?Leu?Ser?Asp
1250????????????????1255????????????????1260
Gly?Gly?Phe?Val?Ala?Phe?Pro?Asp?Leu?Glu?Asp?Leu?Ala?Ala?Ala
1265????????????????1270????????????????1275
Glu?Glu?Val?Pro?Ala?Thr?Val?Leu?Val?Arg?Val?Arg?Pro?Asp?Ala
1280????????????????1285????????????????1290
Ala?Thr?Arg?Pro?Asp?Ala?Val?Val?Asp?Ala?Val?His?Ala?Leu?Ala
1295????????????????1300????????????????1305
Ala?Arg?Gly?Leu?Glu?Leu?Val?Arg?Glu?Trp?Leu?Ala?Gln?Glu?Arg
1310????????????????1315????????????????1320
Phe?Thr?Asp?Ser?Arg?Leu?Val?Phe?Val?Thr?Ser?Asp?Ala?Val?Asp
1325????????????????1330????????????????1335
Gly?Gly?Asp?Leu?Ala?Asp?Ala?Ala?Leu?Arg?Gly?Leu?Val?Arg?Ser
1340????????????????1345????????????????1350
Ala?Val?Ser?Glu?His?Pro?Gly?Arg?Phe?Gly?Leu?Met?Glu?Val?Gly
1355????????????????1360????????????????1365
Arg?Gly?Thr?Asp?Thr?Ala?Thr?Val?Leu?Ala?Ala?Val?Ala?Thr?Gly
1370????????????????1375????????????????1380
Glu?Pro?Glu?Thr?Ala?Ala?Arg?Asp?Gly?Glu?Val?Leu?Ala?Pro?Arg
1385????????????????1390????????????????1395
Leu?Ala?Arg?Ile?Thr?Ser?Gly?Thr?Thr?Thr?Gly?Pro?Arg?Trp?Asp
1400????????????????1405????????????????1410
Ser?Ile?Asp?Gly?Thr?Val?Leu?Leu?Thr?Gly?Gly?Thr?Gly?Gly?Leu
1415????????????????1420????????????????1425
Gly?Arg?Ile?Val?Ala?Arg?His?Leu?Val?Val?Glu?Arg?Gly?Val?Arg
1430????????????????1435????????????????1440
Asp?Leu?Leu?Leu?Val?Ser?Arg?Ser?Gly?Ala?Ala?Ala?Agp?Gly?Ala
1445????????????????1450????????????????1455
Gly?Gln?Leu?Val?Ala?Glu?Leu?Ser?Glu?Thr?Gly?Ala?His?Val?Thr
1460????????????????1465????????????????1470
Val?Glu?Ala?Cys?Asp?Val?Ser?Asp?Pro?Ala?Ala?Val?Ala?Glu?Leu
1475????????????????1480????????????????1485
Val?Ala?Arg?His?Pro?Val?Arg?Ala?Val?Val?His?Ser?Ala?Gly?Val
1490????????????????1495????????????????1500
Leu?Asp?Asp?Gly?Thr?Val?Glu?Ser?Leu?Thr?Ala?Glu?Arg?Val?Thr
1505????????????????1510????????????????1515
Arg?Val?Leu?Arg?Pro?Lys?Ala?Asp?Ala?Ala?Trp?Asn?Leu?His?Glu
1520????????????????1525????????????????1530
Ala?Thr?Arg?Ala?Leu?Asp?Leu?Glu?Ala?Phe?Val?Val?Phe?Ser?Ser
1535????????????????1540????????????????1545
Met?Ser?Gly?Ile?Leu?Gly?Gly?Pro?Gly?Gln?Ala?Asn?Tyr?Ala?Ala
1550????????????????1555????????????????1560
Gly?Asn?Thr?Phe?Leu?Asp?Ala?Leu?Val?Arg?His?Arg?Arg?Ser?Leu
1565????????????????1570????????????????1575
Gly?Leu?Pro?Ala?Thr?Ser?Leu?Ala?Trp?Gly?Pro?Trp?Thr?Gln?Asp
1580????????????????1585????????????????1590
Ala?Gly?Met?Ile?Gly?Thr?Leu?Ser?Gly?Thr?Ser?Arg?His?Arg?Val
1595????????????????1600????????????????1605
Ala?Arg?Ala?Gly?Met?Pro?Glu?Leu?Thr?Ala?Glu?Gln?Gly?Thr?Ala
1610????????????????1615????????????????1620
Leu?Phe?Asp?Ala?Ala?Leu?Ala?Ser?Gly?Glu?Pro?Val?Val?Leu?Pro
1625????????????????1630????????????????1635
Val?Arg?Leu?Asp?Leu?Ala?Ala?Leu?Arg?Gly?Gln?Gly?Asp?Leu?His
1640????????????????1645????????????????1650
Pro?Met?Met?Leu?Gly?Leu?Val?Arg?Arg?Arg?Gly?Arg?Arg?Ala?Ala
1655????????????????1660????????????????1665
Ala?Gly?Gly?Ser?Val?Ala?Ala?Ala?Gly?Leu?Val?Gln?Arg?Leu?Gly
1670????????????????1675????????????????1680
Ala?Leu?Gly?Val?Asp?Glu?Arg?Arg?Glu?Val?Leu?Leu?Asp?Leu?Val
1685????????????????1690????????????????1695
Arg?Gly?Gln?Val?Ala?Val?Val?Leu?Gly?His?Ala?Gly?Val?Gln?Ser
1700????????????????1705????????????????1710
Val?Asp?Pro?Gly?Arg?Ala?Phe?Gln?Asp?Leu?Gly?Phe?Asp?Ser?Leu
1715????????????????1720????????????????1725
Thr?Ala?Val?Glu?Leu?Arg?Asn?Arg?Leu?Gly?Lys?Ser?Thr?Gly?Leu
1730????????????????1735????????????????1740
Arg?Leu?Pro?Ala?Thr?Val?Val?Phe?Asp?Tyr?Pro?Thr?Val?Asn?Ala
1745????????????????1750????????????????1755
Leu?Val?Gly?Tyr?Leu?Leu?Glu?Glu?Leu?Phe?Gly?Gly?Val?Glu?Pro
1760????????????????1765????????????????1770
Ala?Ser?Val?Val?Pro?Val?Ser?Ala?Leu?Pro?Ser?Val?Ala?Glu?Asp
1775????????????????1780????????????????1785
Pro?Ile?Val?Ile?Val?Gly?Met?Ala?Cys?Arg?Tyr?Pro?Gly?Gly?Val
1790????????????????1795????????????????1800
Ser?Ser?Pro?Glu?Asp?Leu?Trp?Thr?Val?Val?Ser?Glu?Gly?Val?Asp
1805????????????????1810????????????????1815
Thr?Val?Ser?Glu?Phe?Pro?Val?Asn?Arg?Gly?Trp?Asp?Val?Asp?Ala
1820????????????????1825????????????????1830
Leu?Tyr?Asn?Pro?Asp?Arg?Asp?Ala?Ser?Gly?Thr?Thr?Tyr?Thr?Lys
1835????????????????1840????????????????1845
Ala?Gly?Gly?Phe?Leu?His?Asp?Ala?Gly?Ala?Phe?Asp?Ser?Glu?Phe
1850????????????????1855????????????????1860
Phe?Gly?Met?Ser?Pro?Arg?Glu?Ala?Val?Ala?Thr?Asp?Ser?Gln?Gln
1865????????????????1870????????????????1875
Arg?Leu?Leu?Leu?Glu?Thr?Thr?Trp?Glu?Ala?Ile?Glu?Arg?Ser?Gly
1880????????????????1885????????????????1890
Ile?Asp?Pro?Ala?Ser?Leu?Arg?Gly?Ser?Gln?Thr?Gly?Val?Phe?Ala
1895????????????????1900????????????????1905
Gly?Val?Met?Tyr?Asn?Asp?Tyr?Gly?Asn?Met?Leu?Ala?Asp?Glu?Arg
1910????????????????1915????????????????1920
Tyr?Glu?Gly?Phe?Arg?Ser?Asn?Gly?Ser?Ala?Pro?Ser?Ile?Ala?Ser
1925????????????????1930????????????????1935
Gly?Arg?Val?Ser?Tyr?Thr?Phe?Gly?Phe?Glu?Gly?Pro?Ala?Val?Thr
1940????????????????1945????????????????1950
Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His?Trp?Ala
1955????????????????1960????????????????1965
Ala?Gln?Ala?Leu?Arg?Ser?Gly?Glu?Cys?Ser?Leu?Ala?Val?Ala?Gly
1970????????????????1975????????????????1980
Gly?Val?Thr?Val?Met?Ser?Thr?Pro?Thr?Thr?Phe?Val?Glu?Phe?Ser
1985????????????????1990????????????????1995
Arg?Gln?Gly?Gly?Leu?Ser?Ala?Asp?Gly?Arg?Cys?Arg?Ser?Phe?Ala
2000????????????????2005????????????????2010
Asp?Ser?Ala?Asp?Gly?Val?Gly?Trp?Ser?Glu?Gly?Val?Gly?Met?Val
2015????????????????2020????????????????2025
Val?Leu?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Arg?Val
2030????????????????2035????????????????2040
Leu?Ala?Val?Val?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser
2045????????????????2050????????????????2055
Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val?Ile
2060????????????????2065????????????????2070
Arg?Gln?Ala?Leu?Ala?Ser?Gly?Gly?Leu?Ser?Ala?Gly?Asp?Val?Asp
2075????????????????2080????????????????2085
Val?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp?Pro?Ile
2090????????????????2095????????????????2100
Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Glu?Arg?Glu?Glu
2105????????????????2110????????????????2115
Gly?Arg?Pro?Leu?Trp?Leu?Gly?Ser?Val?Lys?Ser?Asn?Leu?Gly?His
2120????????????????2125????????????????2130
Thr?Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Val?Met
2135????????????????2140????????????????2145
Ala?Met?Arg?His?Gly?Arg?Leu?Pro?Arg?Thr?Leu?His?Val?Asp?Ala
2150????????????????2155????????????????2160
Pro?Ser?Ser?His?Val?Asp?Trp?Ser?Ala?Gly?Ala?Val?Glu?Leu?Leu
2165????????????????2170????????????????2175
Thr?Gly?Glu?Arg?Val?Trp?Pro?Gly?Glu?Glu?Arg?Leu?Arg?Arg?Ala
2180????????????????2185????????????????2190
Gly?Val?Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr?Asn?Ala?His?Val?Ile
2195????????????????2200????????????????2205
Leu?Glu?Gln?Pro?Glu?Pro?Val?Ala?Glu?Pro?Glu?Thr?Gly?Gly?Asp
2210????????????????2215????????????????2220
Gly?Ile?Ala?Ala?Leu?Ala?Pro?Gly?Ile?Val?Pro?Trp?Val?Leu?Ser
2225????????????????2230????????????????2235
Gly?Arg?Thr?Glu?Glu?Ala?Leu?Arg?Ala?Gln?Ala?Ala?Arg?Leu?Leu
2240????????????????2245????????????????2250
Ala?Gln?Val?Glu?Gly?His?Pro?Gly?Leu?Arg?Pro?Val?Asp?Leu?Ala
2255????????????????2260????????????????2265
Leu?Ser?Leu?Ala?Thr?Gln?Arg?Ser?Leu?Phe?Asp?His?Arg?Ala?Val
2270????????????????2275????????????????2280
Val?Leu?Thr?Asp?Asp?Arg?Glu?Thr?Ala?Val?Arg?Gly?Leu?Ala?Ala
2285????????????????2290????????????????2295
Val?Cys?Val?Gly?Glu?Pro?Asp?Pro?Ala?Val?Val?Leu?Gly?Ala?Val
2300????????????????2305????????????????2310
Glu?Pro?Gly?Arg?Thr?Ala?Phe?Leu?Phe?Ser?Gly?Gln?Gly?Ser?Gln
2315????????????????2320????????????????2325
Arg?Leu?Gly?Met?Gly?Arg?Gly?Leu?Tyr?Glu?Arg?Phe?Pro?Val?Phe
2330????????????????2335????????????????2340
Ala?Glu?Ala?Phe?Asp?Ala?Val?Cys?Ala?Gly?Leu?Asp?Ala?His?Leu
2345????????????????2350????????????????2355
Asp?Arg?Pro?Leu?Arg?Glu?Val?Val?Trp?Gly?Asp?Asp?Thr?Ser?Val
2360????????????????2365????????????????2370
Leu?Asp?Gly?Thr?Ala?Tyr?Ala?Gln?Ala?Gly?Leu?Phe?Ala?Val?Glu
2375????????????????2380????????????????2385
Val?Ala?Leu?Phe?Arg?Leu?Val?Glu?Ser?Trp?Gly?Val?Arg?Pro?Glu
2390????????????????2395????????????????2400
Phe?Val?Ala?Gly?His?Ser?Ile?Gly?Glu?Val?Ala?Ala?Ala?His?Val
2405????????????????2410????????????????2415
Ala?Gly?Val?Phe?Ser?Leu?Ala?Asp?Ala?Cys?Val?Leu?Val?Ala?Ala
2420????????????????2425????????????????2430
Arg?Gly?Arg?Leu?Met?Gln?Ala?Leu?Pro?Glu?Gly?Gly?Ala?Met?Val
2435????????????????2440????????????????2445
Ala?Val?Glu?Ala?Ser?Glu?Ala?Glu?Val?Leu?Pro?Arg?Leu?Glu?Ser
2450????????????????2455????????????????2460
Val?Glu?Gly?Val?Ser?Val?Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val
2465????????????????2470????????????????2475
Val?Val?Ser?Gly?Ala?Glu?Glu?Ala?Val?Glu?Ala?Val?Ala?Glu?Val
2480????????????????2485????????????????2490
Phe?Arg?Glu?Leu?Gly?Arg?Arg?Val?Ser?Arg?Leu?Arg?Val?Ser?His
2495????????????????2500????????????????2505
Ala?Phe?His?Ser?Pro?Leu?Met?Glu?Pro?Met?Leu?Asp?Ala?Phe?His
2510????????????????2515????????????????2520
Glu?Val?Leu?Arg?Asp?Leu?Ser?Phe?Ala?Glu?Pro?Arg?Leu?Pro?Val
2525????????????????2530????????????????2535
Val?Ser?Asn?Val?Ser?Gly?Arg?Ile?Ala?Glu?Pro?Gly?Glu?Leu?Thr
2540????????????????2545????????????????2550
Ala?Pro?Asp?Tyr?Trp?Val?Arg?His?Val?Arg?Glu?Ala?Val?Arg?Phe
2555????????????????2560????????????????2565
Asp?Asp?Gly?Val?Arg?Ala?Leu?Ala?Glu?Glu?Gly?Val?Thr?Arg?Phe
2570????????????????2575????????????????2580
Val?Glu?Leu?Gly?Pro?Asp?Gly?Val?Leu?Ser?Gly?Met?Ala?Arg?Ala
2585????????????????2590????????????????2595
Ser?Ala?Gly?Glu?Asp?Ala?Val?Leu?Val?Pro?Leu?Leu?Arg?Lys?Asp
2600????????????????2605????????????????2610
Arg?Glu?Glu?Val?Ala?Val?Ala?Leu?Ser?Ala?Leu?Ala?Glu?Leu?His
2615????????????????2620????????????????2625
Val?Arg?Gly?Val?Ser?Ala?Gly?Trp?Gly?Ala?Val?Leu?Asp?Gly?Thr
2630????????????????2635????????????????2640
Gly?Gly?Arg?Ala?Val?Asp?Leu?Pro?Thr?Tyr?Ala?Phe?Gln?His?Glu
2645????????????????2650????????????????2655
His?Tyr?Trp?Pro?Thr?Gly?Thr?Thr?Thr?Gly?Thr?Gly?Asp?Ile?Arg
2660????????????????2665????????????????2670
Leu?Ala?Gly?Leu?Gly?Ala?Ala?Gly?His?Pro?Leu?Leu?Gly?Ala?Ala
2675????????????????2680????????????????2685
Val?Glu?Leu?Ala?Gly?Ala?Asp?Gly?Leu?Ile?Leu?Thr?Gly?Arg?Leu
2690????????????????2695????????????????2700
Ser?Thr?Arg?Ser?His?Pro?Trp?Leu?Ala?Asp?His?Val?Val?Gln?Gly
2705????????????????2710????????????????2715
Ala?Val?Leu?Val?Pro?Gly?Thr?Ala?Leu?Leu?Glu?Met?Ala?Val?Arg
2720????????????????2725????????????????2730
Ala?Ala?Asp?Glu?Ala?Gly?Cys?Gly?Ser?Val?Glu?Glu?Leu?Thr?Leu
2735????????????????2740????????????????2745
Ser?Ala?Pro?Leu?Val?Leu?Pro?Glu?Arg?Gly?Ala?Val?Arg?Val?Gln
2750????????????????2755????????????????2760
Val?Gly?Val?Gly?Glu?Pro?Asp?Glu?Ser?Gly?Arg?Arg?Thr?Val?Ala
2765????????????????2770????????????????2775
Ile?His?Ser?Arg?Asp?Asp?Gly?Asp?Glu?Arg?Gln?Pro?Trp?Ser?Leu
2780????????????????2785????????????????2790
His?Ala?Gln?Gly?Val?Leu?Ala?Pro?Glu?Thr?Ile?Asp?Ala?Asp?Pro
2795????????????????2800????????????????2805
Ala?Ala?Glu?Gly?Phe?Asp?Ala?Ser?Val?Trp?Pro?Pro?Arg?Asp?Ala
2810????????????????2815????????????????2820
Val?Pro?Val?Asp?Val?Thr?Asp?Cys?Tyr?Glu?Ser?Leu?Ala?Glu?Ala
2825????????????????2830????????????????2835
Gly?Leu?Arg?Tyr?Gly?Pro?Val?Phe?Gln?Gly?Leu?Arg?Ala?Ala?Trp
2840????????????????2845????????????????2850
Arg?Arg?Asp?Asp?Glu?Val?Phe?Ala?Glu?Val?Ala?Leu?Pro?Asp?Gly
2855????????????????2860????????????????2865
Val?Asp?Ala?Thr?Ala?Phe?Gly?Leu?His?Pro?Ala?Leu?Phe?Asp?Ala
2870????????????????2875????????????????2880
Ala?Leu?His?Ala?Ser?Phe?Ala?Phe?Gly?Gly?Asp?Asp?Ala?Pro?Gly
2885????????????????2890????????????????2895
Gly?Val?Pro?Phe?Val?Trp?Glu?Asn?Ala?Thr?Leu?His?Ala?Ser?Gly
2900????????????????2905????????????????2910
Ala?Ser?Val?Leu?Arg?Thr?Arg?Leu?Thr?Arg?Thr?Gly?Asp?Asp?Thr
2915????????????????2920????????????????2925
Leu?Ala?Val?His?Val?Ala?Asp?Pro?Thr?Gly?Ala?Pro?Val?Ala?Ser
2930????????????????2935????????????????2940
Val?Gly?Ser?Leu?Thr?Val?Arg?Ala?Ala?Ala?Gly?Ala?Arg?Ala?Ala
2945????????????????2950????????????????2955
Asp?Thr?Ala?Glu?Pro?Leu?Tyr?Arg?Val?Glu?Trp?Val?Pro?Ala?Arg
2960????????????????2965????????????????2970
Gly?Thr?Arg?Ala?Thr?Pro?Ala?Ala?Gly?Ser?Val?Val?Leu?Leu?Gly
2975????????????????2980????????????????2985
Glu?Gly?Leu?Ala?Asp?Leu?Ala?Gly?Asp?Gly?Ala?Ala?Val?Arg?Ala
2990????????????????2995????????????????3000
Asp?Leu?Gln?Glu?Leu?Ala?Ala?Ala?Glu?Ala?Val?Pro?Glu?Thr?Val
3005????????????????3010????????????????3015
Val?Val?Ala?Val?Pro?Pro?Ala?Pro?Asp?Thr?Glu?Gly?Val?Val?Gly
3020????????????????3025????????????????3030
Ser?Ala?His?Ala?Ser?Ala?Ala?Trp?Ala?Leu?Ala?Leu?Val?Lys?Glu
3035????????????????3040????????????????3045
Trp?Leu?Ala?Gln?Glu?Arg?Phe?Ala?Gly?Ser?Arg?Leu?Val?Phe?Ile
3050????????????????3055????????????????3060
Thr?Arg?Gly?Gly?His?Val?Thr?Glu?Pro?Ala?Ser?Ala?Leu?Thr?Ser
3065????????????????3070????????????????3075
Ala?Pro?Val?Arg?Gly?Leu?Val?Arg?Ser?Val?Ala?Leu?Glu?His?Pro
3080????????????????3085????????????????3090
Gly?Arg?Phe?Gly?Leu?Leu?His?Leu?Pro?Ala?Gly?Thr?Asp?Ala?Gly
3095????????????????3100????????????????3105
Arg?Leu?Phe?Ala?Ala?Leu?Ala?Val?Asp?Glu?Pro?Glu?Thr?Ala?Val
3110????????????????3115????????????????3120
Leu?Asp?Ser?Glu?Val?Cys?Val?Pro?Arg?Leu?Val?Arg?Thr?Thr?Pro
3125????????????????3130????????????????3135
Asp?Ala?Gly?Gly?Glu?Glu?Thr?Ala?Gly?Ser?Ser?Ala?Gly?Leu?Gly
3140????????????????3145????????????????3150
Ser?Gly?Thr?Val?Leu?Leu?Thr?Gly?Gly?Thr?Gly?Gly?Leu?Gly?Arg
3155????????????????3160????????????????3165
Ile?Val?Ala?Arg?His?Leu?Val?Val?Glu?Arg?Gly?Val?Arg?Asp?Leu
3170????????????????3175????????????????3180
Leu?Leu?Val?Ser?Arg?Ser?Gly?Ala?Ala?Ala?Glu?Gly?Val?Asp?Ala
3185????????????????3190????????????????3195
Phe?Thr?Ala?Glu?Leu?Thr?Gly?Leu?Gly?Ala?Arg?Val?Ser?Val?Ala
3200????????????????3205????????????????3210
Ala?Cys?Asp?Leu?Ala?Asp?Arg?Thr?Ala?Leu?Asp?Ala?Leu?Leu?Ala
3215????????????????3220????????????????3225
Gly?Val?Pro?Ala?Asp?Arg?Pro?Val?Arg?Ala?Val?Val?His?Ala?Ala
3230????????????????3235????????????????3240
Gly?Val?Leu?Asp?Asp?Gly?Met?Ala?Glu?Ser?Leu?Thr?Ala?Glu?Arg
3245????????????????3250????????????????3255
Val?Ala?Ala?Val?Leu?Arg?Pro?Lys?Val?Asp?Ala?Ala?Trp?Asn?Leu
3260????????????????3265????????????????3270
His?Glu?Ala?Thr?Arg?Gly?Leu?Asp?Leu?Glu?Ala?Phe?Val?Val?Phe
3275????????????????3280????????????????3285
Ser?Ser?Val?Ala?Gly?Thr?Phe?Gly?Ser?Ala?Gly?Gln?Gly?Ala?Tyr
3290????????????????3295????????????????3300
Ala?Ala?Gly?Asn?Val?Phe?Leu?Asp?Ala?Leu?Val?Glu?Tyr?Arg?Arg
3305????????????????3310????????????????3315
Ser?Leu?Gly?Leu?Pro?Gly?Val?Ser?Leu?Val?Trp?Gly?Pro?Trp?Ala
3320????????????????3325????????????????3330
Gln?Asp?Ala?Gly?Met?Thr?Arg?Gly?Leu?Ser?Glu?Thr?Asp?Arg?Arg
3335????????????????3340????????????????3345
Arg?Ile?Ala?Arg?Ser?Gly?Leu?Pro?Pro?Val?Glu?Ala?Glu?Gln?Gly
3350????????????????3355????????????????3360
Thr?Ala?Leu?Phe?Asp?Ala?Ala?Leu?Ala?Ser?Gly?Glu?Pro?Val?Val
3365????????????????3370????????????????3375
Leu?Pro?Val?Arg?Leu?Asp?Leu?Ala?Ala?Leu?Arg?Gly?Glu?Glu?Asp
3380????????????????3385????????????????3390
Val?Pro?Ala?Leu?Phe?Arg?Gly?Leu?Val?Arg?Arg?Arg?Gly?Arg?Arg
3395????????????????3400????????????????3405
Ala?Ala?Ala?Gly?Gly?Ser?Val?Ala?Ala?Ala?Gly?Leu?Val?Gln?Arg
3410????????????????3415????????????????3420
Leu?Gly?Ala?Leu?Gly?Val?Asp?Glu?Arg?Arg?Glu?Val?Leu?Leu?Asp
3425????????????????3430????????????????3435
Leu?Val?Arg?Gly?Gln?Val?Ala?Val?Val?Leu?Gly?His?Ala?Gly?Val
3440????????????????3445????????????????3450
Gln?Ser?Val?Asp?Pro?Gly?Arg?Ala?Phe?Gln?Asp?Leu?Gly?Phe?Asp
3455????????????????3460????????????????3465
Ser?Leu?Thr?Ala?Val?Glu?Leu?Arg?Asn?Arg?Leu?Gly?Lys?Ser?Thr
3470????????????????3475????????????????3480
Gly?Leu?Arg?Leu?Pro?Ala?Thr?Val?Val?Phe?Asp?Tyr?Pro?Thr?Val
3485????????????????3490????????????????3495
Asn?Ala?Leu?Val?Gly?Tyr?Leu?Leu?Glu?Glu?Leu?Phe?Gly?Gly?Val
3500????????????????3505????????????????3510
Glu?Pro?Ala?Ala?Val?Val?Pro?Val?Ser?Ala?Leu?Pro?Ser?Val?Ala
3515????????????????3520????????????????3525
Glu?Asp?Pro?Ile?Val?Ile?Val?Gly?Met?Ala?Cys?Arg?Tyr?Pro?Gly
3530????????????????3535????????????????3540
Gly?Val?Ser?Ser?Pro?Glu?Asp?Leu?Trp?Arg?Val?Val?Ser?Glu?Gly
3545????????????????3550????????????????3555
Val?Asp?Thr?Val?Ser?Asp?Phe?Pro?Ser?Asp?Arg?Gly?Trp?Asp?Val
3560????????????????3565????????????????3570
Asp?Ala?Leu?Tyr?Asn?Pro?Asp?Arg?Ala?Val?Pro?Gly?Thr?Ser?Tyr
3575????????????????3580????????????????3585
Thr?Arg?Ser?Gly?Gly?Phe?Leu?His?Asp?Ala?Pro?Glu?Phe?Asp?Pro
3590????????????????3595????????????????3600
Glu?Phe?Phe?Gly?Met?Ser?Pro?Arg?Glu?Ala?Val?Ser?Thr?Asp?Ala
3605????????????????3610????????????????3615
Gln?Gln?Arg?Leu?Leu?Leu?Glu?Thr?Thr?Trp?Glu?Ala?Ile?Glu?Arg
3620????????????????3625????????????????3630
Ser?Gly?Ile?Asp?Pro?Val?Ser?Leu?Arg?Gly?Ser?Gln?Thr?Gly?Val
3635????????????????3640????????????????3645
Phe?Ala?Gly?Val?Met?Tyr?His?Asp?Tyr?Ala?Asn?Leu?Leu?Ala?Ser
3650????????????????3655????????????????3660
Pro?Glu?Tyr?Glu?Gly?Tyr?Gln?Gly?Ser?Gly?Ser?Ala?Gly?Ser?Val
3665????????????????3670????????????????3675
Ala?Ser?Gly?Arg?Val?Ser?Tyr?Thr?Phe?Gly?Phe?Glu?Gly?Pro?Ala
3680????????????????3685????????????????3690
Val?Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His
3695????????????????3700????????????????3705
Trp?Ala?Ala?Gln?Ala?Leu?Arg?Ser?Gly?Glu?Cys?Ser?Leu?Ala?Val
3710????????????????3715????????????????3720
Ala?Gly?Gly?Val?Thr?Val?Met?Ser?Thr?Pro?Ser?Thr?Phe?Val?Glu
3725????????????????3730????????????????3735
Phe?Ser?Arg?Gln?Gly?Gly?Leu?Ser?Ala?Asp?Gly?Arg?Cys?Arg?Ser
3740????????????????3745????????????????3750
Phe?Ala?Asp?Ser?Ala?Asp?Gly?Val?Gly?Trp?Ser?Glu?Gly?Val?Gly
3755????????????????3760????????????????3765
Met?Val?Val?Leu?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His
3770????????????????3775????????????????3780
Arg?Val?Leu?Ala?Val?Val?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly
3785????????????????3790????????????????3795
Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg
3800????????????????3805????????????????3810
Val?Ile?Arg?Gln?Ala?Leu?Ala?Ser?Gly?Gly?Leu?Ser?Ala?Gly?Asp
3815????????????????3820????????????????3825
Val?Asp?Val?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp
3830????????????????3835????????????????3840
Pro?Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Gly?Arg
3845????????????????3850????????????????3855
Asp?Glu?Glu?Arg?Pro?Leu?Leu?Leu?Gly?Ser?Val?Lys?Ser?Asn?Ile
3860????????????????3865????????????????3870
Gly?His?Thr?Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met
3875????????????????3880????????????????3885
Val?Met?Ala?Met?Arg?His?Gly?Arg?Leu?Pro?Arg?Thr?Leu?His?Val
3890????????????????3895????????????????3900
Asp?Ala?Pro?Ser?Ser?His?Val?Asp?Trp?Ser?Ala?Gly?Ala?Val?Glu
3905????????????????3910????????????????3915
Leu?Leu?Thr?Gly?Glu?Arg?Val?Trp?Pro?Gly?Glu?Glu?Arg?Ala?Arg
3920????????????????3925????????????????3930
Arg?Ala?Gly?Val?Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr?Asn?Ala?His
3935????????????????3940????????????????3945
Val?Ile?Leu?Glu?Gln?Pro?Glu?Pro?Val?Thr?Gly?Ser?Gly?Pro?Gly
3950????????????????3955????????????????3960
Glu?Ala?Asp?Gly?Thr?Glu?Ala?Ser?Ser?Gly?Val?Gln?Pro?Trp?Val
3965????????????????3970????????????????3975
Leu?Ser?Ala?Arg?Thr?Glu?Glu?Ala?Leu?Arg?Ala?Gln?Ala?Ala?Arg
3980????????????????3985????????????????3990
Leu?Ala?Asp?Phe?Leu?Thr?Asp?Ala?Pro?Ala?Asp?Val?Arg?Asp?Val
3995????????????????4000????????????????4005
Ala?Leu?Ser?Leu?Ala?Thr?Gln?Arg?Thr?Leu?Phe?Asp?His?Arg?Ala
4010????????????????4015????????????????4020
Val?Val?Leu?Gly?Ala?Asp?Leu?Glu?Thr?Ala?Leu?Thr?Ser?Leu?Arg
4025????????????????4030????????????????4035
Ala?Leu?Ala?Ala?Gly?Ala?Pro?Asp?Ala?Ala?Val?Ala?Glu?Gly?Val
4040????????????????4045????????????????4050
Ala?Gly?Asn?Gly?Arg?Thr?Ala?Phe?Leu?Phe?Pro?Gly?Gln?Gly?Ser
4055????????????????4060????????????????4065
Gln?Arg?Leu?Gly?Met?Gly?Arg?Asp?Leu?Tyr?Glu?Arg?Phe?Pro?Val
4070????????????????4075????????????????4080
Leu?Ala?Glu?Ala?Phe?Asp?Ala?Val?Cys?Ala?Glu?Leu?Asp?Glu?His
4085????????????????4090????????????????4095
Leu?Asp?Arg?Pro?Leu?Arg?Glu?Val?Val?Trp?Gly?Asp?Asp?Ala?Glu
4100????????????????4105????????????????4110
Leu?Leu?Asn?Arg?Thr?Ala?Tyr?Ala?Gln?Pro?Gly?Leu?Phe?Ala?Val
4115????????????????4120????????????????4125
Glu?Val?Ala?Leu?Phe?Arg?Leu?Val?Glu?Ser?Trp?Gly?Val?Arg?Pro
4130????????????????4135????????????????4140
Glu?Phe?Val?Ala?Gly?His?Ser?Ile?Gly?Glu?Val?Ala?Ala?Ala?His
4145????????????????4150????????????????4155
Val?Ala?Gly?Val?Phe?Thr?Leu?Ala?Asp?Ala?Ala?Ala?Leu?Val?Ala
4160????????????????4165????????????????4170
Ala?Arg?Gly?Arg?Leu?Met?Gln?Ala?Leu?Pro?Glu?Gly?Gly?Ala?Met
4175????????????????4180????????????????4185
Ala?Ala?Val?Glu?Ala?Thr?Cys?Ala?Glu?Val?Leu?Pro?His?Leu?Thr
4190????????????????4195????????????????4200
Gly?Asn?Leu?Ser?Ile?Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val?Val
4205????????????????4210????????????????4215
Val?Ser?Gly?Ser?Glu?Ala?Ser?Val?Glu?Ser?Val?Ala?Glu?Val?Phe
4220????????????????4225????????????????4230
Arg?Glu?Leu?Gly?Arg?Arg?Val?Ser?Arg?Leu?Arg?Val?Ser?His?Ala
4235????????????????4240????????????????4245
Phe?His?Ser?Pro?Leu?Met?Glu?Pro?Met?Leu?His?Ala?Phe?Arg?Glu
4250????????????????4255????????????????4260
Val?Val?Glu?Gly?Leu?Ser?Phe?Ala?Ala?Pro?Arg?Ile?Pro?Leu?Val
4265????????????????4270????????????????4275
Ser?Asn?Ile?Thr?Gly?Thr?Leu?Ala?Glu?Pro?Gly?Gln?Val?Asp?Glu
4280????????????????4285????????????????4290
Pro?Glu?Tyr?Trp?Val?Thr?His?Val?Arg?Glu?Ala?Val?Arg?Phe?Asp
4295????????????????4300????????????????4305
Asp?Gly?Val?Arg?Ala?Leu?Ala?Glu?Glu?Gly?Val?Thr?Arg?Phe?Val
4310????????????????4315????????????????4320
Glu?Val?Gly?Pro?Asp?Gly?Val?Leu?Ser?Gly?Met?Ala?Arg?Glu?Ser
4325????????????????4330????????????????4335
Ala?Gly?Glu?Asp?Ala?Val?Leu?Val?Pro?Leu?Leu?Arg?Lys?Asp?Arg
4340????????????????4345????????????????4350
Glu?Glu?Thr?Gly?Ser?Ala?Leu?Ser?Ala?Leu?Gly?Arg?Leu?His?Thr
4355????????????????4360????????????????4365
Val?Gly?Val?Asp?Val?Asp?Trp?Ser?Gly?Phe?Leu?Val?Gly?Ala?Arg
4370????????????????4375????????????????4380
Pro?Val?Asp?Leu?Pro?Thr?Tyr?Ala?Phe?Gln?Lys?Gln?Arg?Tyr?Trp
4385????????????????4390????????????????4395
Pro?Glu?Ala?Thr?Leu?Pro?Arg?Ala?Gly?Asp?Val?Arg?Phe?Ala?Gly
4400????????????????4405????????????????4410
Leu?Gly?Ser?Ala?Gly?His?Pro?Leu?Leu?Gly?Ala?Ala?Val?Glu?Leu
4415????????????????4420????????????????4425
Ala?Gly?Ala?Asp?Gly?Ala?Asp?Gly?Val?Val?Leu?Thr?Gly?Arg?Leu
4430????????????????4435????????????????4440
Ser?Thr?Arg?Ser?His?Pro?Trp?Leu?Ala?Asp?His?Val?Val?Gln?Gly
4445????????????????4450????????????????4455
Thr?Val?Leu?Val?Pro?Gly?Thr?Ala?Leu?Leu?Glu?Met?Ala?Val?Arg
4460????????????????4465????????????????4470
Ala?Ala?Asp?Glu?Ala?Gly?Cys?Gly?Ser?Val?Glu?Glu?Leu?Thr?Leu
4475????????????????4480????????????????4485
Ser?Ala?Pro?Leu?Val?Leu?Pro?Glu?Arg?Gly?Ala?Leu?Gln?Ile?Gln
4490????????????????4495????????????????4500
Ile?Arg?Val?Ala?Ala?Pro?Asp?Glu?Asp?Gly?Arg?Arg?Ala?Leu?Gly
4505????????????????4510????????????????4515
Val?His?Ala?Arg?Thr?Glu?Asp?Asp?Asp?Gly?Ala?Pro?Trp?Thr?Val
4520????????????????4525????????????????4530
His?Ala?Thr?Gly?Thr?Leu?Ala?Pro?Glu?Thr?Leu?Ala?Pro?Asp?Pro
4535????????????????4540????????????????4545
Phe?Asp?Ala?Thr?Val?Trp?Pro?Pro?Arg?Asp?Ala?Ala?Gln?Val?Asp
4550????????????????4555????????????????4560
Val?Thr?Asp?Cys?Tyr?Glu?Arg?Leu?Ala?Glu?Ala?Gly?Phe?Ala?Tyr
4565????????????????4570????????????????4575
Gly?Pro?Ala?Phe?Arg?Gly?Leu?Arg?Ala?Ala?Trp?Arg?His?Gly?Asp
4580????????????????4585????????????????4590
Ala?Leu?Tyr?Ala?Glu?Val?Ala?Leu?Asp?Gly?Gly?Thr?Asp?Gly?Asp
4595????????????????4600????????????????4605
Ala?Phe?Gly?Leu?His?Pro?Ala?Leu?Phe?Asp?Ala?Ala?Leu?His?Ala
4610????????????????4615????????????????4620
Phe?Ala?Leu?Ala?Asp?Asp?Gly?Arg?Gly?Gly?Val?Pro?Phe?Ser?Trp
4625????????????????4630????????????????4635
Gly?Gly?Val?Ser?Leu?His?Ala?Ser?Gly?Ala?Thr?Ala?Leu?Arg?Val
4640????????????????4645????????????????4650
Arg?Leu?Thr?Arg?Asp?Ala?Asp?Gly?Thr?Met?Ala?Leu?Ala?Leu?Ala
4655????????????????4660????????????????4665
Asp?Pro?Ala?Gly?Ser?Pro?Val?Ala?Thr?Val?His?Ser?Leu?Thr?Val
4670????????????????4675????????????????4680
Arg?Pro?Leu?Ala?Thr?Gly?Gln?Leu?Thr?Thr?Pro?Ala?Arg?Asp?Ser
4685????????????????4690????????????????4695
Leu?Tyr?Gln?Val?Glu?Trp?Val?Pro?Ala?Arg?Pro?Leu?Asp?Gly?Pro
4700????????????????4705????????????????4710
Ala?Asp?Thr?Gly?Ala?Val?Ala?Val?Leu?Gly?Glu?Ala?Arg?Ser?Ala
4715????????????????4720????????????????4725
Val?Pro?Ala?Ala?Asp?Asp?Phe?Val?Thr?Tyr?Ala?Thr?Leu?Glu?Glu
4730????????????????4735????????????????4740
Leu?Ala?Ala?Ala?Glu?Glu?Met?Pro?Ser?Thr?Val?Leu?Val?Ala?Ala
4745????????????????4750????????????????4755
Ser?Asp?Asp?Ala?Asp?Gly?Thr?Asp?Pro?Ala?Gln?Ala?Ala?His?Thr
4760????????????????4765????????????????4770
Ala?Ala?Ala?Arg?Ala?Leu?Ala?Leu?Val?Arg?Ser?Trp?Leu?Ala?Glu
4775????????????????4780????????????????4785
Asp?Arg?Phe?Ala?Gly?Ser?Arg?Leu?Val?Phe?Val?Thr?Ala?Ser?Thr
4790????????????????4795????????????????4800
Asp?Arg?Thr?Thr?Gly?Leu?Ala?Asp?Ala?Ala?Ala?Arg?Gly?Leu?Val
4805????????????????4810????????????????4815
Arg?Ser?Ala?Ile?Ser?Glu?His?Pro?Gly?Arg?Phe?Gly?Leu?Leu?Glu
4820????????????????4825????????????????4830
Leu?Pro?Ala?Asp?Ala?Asp?Thr?Ala?Ser?Leu?Arg?Ser?Ala?Leu?Ala
4835????????????????4840????????????????4845
Ser?Gly?Glu?Ala?Glu?Ser?Val?Val?Arg?Asp?Gly?Glu?Val?Arg?Val
4850????????????????4855????????????????4860
Pro?Arg?Leu?Ala?Arg?Val?Thr?Pro?Glu?Ala?Thr?Glu?Gly?Leu?Arg
4865????????????????4870????????????????4875
Trp?Asp?Ala?Leu?Thr?Gly?Pro?Val?Leu?Ile?Thr?Gly?Gly?Thr?Gly
4880????????????????4885????????????????4890
Gly?Leu?Gly?Arg?Val?Leu?Ala?Arg?His?Leu?Val?Met?Thr?His?Gly
4895????????????????4900????????????????4905
Val?Arg?Asp?Leu?Leu?Leu?Val?Ser?Arg?Ser?Gly?Ala?Asn?Ala?Glu
4910????????????????4915????????????????4920
Gly?Ala?Gly?Glu?Leu?Val?Thr?Glu?Leu?Thr?Glu?Ala?Gly?Ala?His
4925????????????????4930????????????????4935
Val?Ala?Val?Glu?Ala?Cys?Asp?Ala?Ala?Asp?Ala?Asp?Ala?Val?Ala
4940????????????????4945????????????????4950
Gly?Leu?Val?Thr?Arg?His?Gly?Val?Arg?Ala?Val?Val?His?Ala?Ala
4955????????????????4960????????????????4965
Gly?Val?lle?Asp?Asp?Ala?Thr?Leu?Ala?Ser?Leu?Thr?Ala?Glu?Arg
4970????????????????4975????????????????4980
Val?Ala?Ala?Val?Leu?Arg?Pro?Lys?Val?Asp?Ala?Ala?Trp?Asn?Leu
4985????????????????4990????????????????4995
His?Glu?Ala?Thr?Arg?Asp?Leu?Gly?Leu?Glu?Ala?Phe?Val?Val?Phe
5000????????????????5005????????????????5010
Ser?Ser?Val?Ala?Gly?Thr?Phe?Gly?Ser?Ala?Gly?Gln?Gly?Ala?Tyr
5015????????????????5020????????????????5025
Ala?Ala?Gly?Asn?Val?Phe?Leu?Asp?Ala?Leu?Val?Glu?Tyr?Arg?Arg
5030????????????????5035????????????????5040
Ala?Leu?Gly?Leu?Pro?Gly?Val?Ser?Leu?Val?Trp?Gly?Pro?Trp?Ala
5045????????????????5050????????????????5055
Gln?Asp?Ala?Gly?Met?Thr?Arg?Glu?Leu?Ser?Glu?Thr?Asp?Arg?Arg
5060????????????????5065????????????????5070
Arg?Ile?Ala?Arg?Ser?Gly?Leu?Pro?Pro?Val?Glu?Ala?Glu?Gln?Gly
5075????????????????5080????????????????5085
Thr?Ala?Leu?Phe?Asp?Ala?Ala?Leu?Ala?Ser?Gly?Glu?Pro?Val?Val
5090????????????????5095????????????????5100
Leu?Pro?Val?Arg?Leu?Asp?Leu?Pro?Ala?Leu?Arg?Ala?Gln?Gly?Glu
5105????????????????5110????????????????5115
Val?Pro?Pro?Leu?Leu?Ser?Gly?Leu?Ile?Arg?Thr?Ser?Val?Arg?Arg
5120????????????????5125????????????????5130
Thr?Ala?Ala?Ala?Ala?Gly?Ala?Ala?Ala?Thr?Gly?Leu?Ala?Ala?Arg
5135????????????????5140????????????????5145
Leu?Ala?Gly?Leu?Ala?Glu?Ala?Glu?Arg?Arg?Glu?Val?Leu?Leu?Asp
5150????????????????5155????????????????5160
Leu?Val?Arg?Gly?Gln?Ile?Ala?Val?Val?Leu?Gly?His?Ser?Gly?Ala
5165????????????????5170????????????????5175
Gln?Thr?Val?Asn?Pro?His?Arg?Ala?Phe?Gln?Asp?Leu?Gly?Phe?Asp
5180????????????????5185????????????????5190
Ser?Leu?Thr?Ala?Val?Glu?Leu?Arg?Asn?Arg?Leu?Gly?Lys?Val?Thr
5195????????????????5200????????????????5205
Gly?Leu?Arg?Leu?Pro?Ala?Thr?Val?Val?Phe?Asp?Tyr?Pro?Thr?Ala
5210????????????????5215????????????????5220
Asp?Leu?Leu?Ala?Gly?His?Leu?Leu?Asp?Gly?Val?Leu?Gly?Thr?Glu
5225????????????????5230????????????????5235
Pro?Ala?Val?Ala?Val?Pro?Val?Ala?Ala?Leu?Pro?Ser?Val?Ala?Asp
5240????????????????5245????????????????5250
Asp?Pro?Val?Val?Ile?Val?Gly?Met?Ala?Cys?Arg?Tyr?Pro?Gly?Gly
5255????????????????5260????????????????5265
Val?Thr?Ser?Pro?Glu?Asp?Leu?Trp?Ser?Val?Val?Ser?Asp?Gly?Val
5270????????????????5275????????????????5280
Asp?Ala?Val?Gly?Asp?Phe?Pro?Ser?Asp?Arg?Gly?Trp?Asp?Val?Glu
5285????????????????5290????????????????5295
Ser?Leu?Tyr?Ser?Glu?Asp?Arg?Gly?Val?Pro?Gly?Thr?Thr?Tyr?Thr
5300????????????????5305????????????????5310
Arg?Ser?Gly?Gly?Phe?Leu?His?Asp?Ala?Pro?Glu?Phe?Asp?Pro?Glu
5315????????????????5320????????????????5325
Phe?Phe?Gly?Met?Ser?Pro?Arg?Glu?Ala?Val?Ser?Thr?Asp?Ala?Gln
5330????????????????5335????????????????5340
Gln?Arg?Leu?Leu?Leu?Glu?Thr?Thr?Trp?Glu?Ala?Ile?Glu?Arg?Ser
5345????????????????5350????????????????5355
Gly?Ile?Asp?Pro?Val?Ser?Leu?Arg?Gly?Ser?Gln?Thr?Gly?Val?Phe
5360????????????????5365????????????????5370
Ala?Gly?Val?Met?Tyr?Asn?Asp?Tyr?Gly?Ser?Ile?Leu?Thr?Asp?Asp
5375????????????????5380????????????????5385
Gln?Tyr?Glu?Gly?Tyr?Arg?Gly?Asn?Gly?Ser?Ala?Gly?Ser?Ile?Ala
5390????????????????5395????????????????5400
Ser?Gly?Arg?Val?Ser?Tyr?Thr?Phe?Gly?Phe?Glu?Gly?Pro?Ala?Val
5405????????????????5410????????????????5415
Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Met?His?Trp
5420????????????????5425????????????????5430
Ala?Ala?Gln?Ala?Leu?Arg?Ser?Gly?Glu?Cys?Ser?Leu?Ala?Val?Ala
5435????????????????5440????????????????5445
Gly?Gly?Val?Thr?Val?Met?Ala?Thr?Pro?Thr?Ala?Phe?Val?Glu?Phe
5450????????????????5455????????????????5460
Ser?Arg?Gln?Gly?Ala?Leu?Ser?Pro?Asp?Ser?Arg?Cys?Lys?Ala?Phe
5465????????????????5470????????????????5475
Ser?Asp?Ala?Ala?Asp?Gly?Ala?Gly?Trp?Ser?Glu?Gly?Val?Gly?Met
5480????????????????5485????????????????5490
Val?Val?Leu?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Arg
5495????????????????5500????????????????5505
Val?Leu?Ala?Val?Val?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala
5510????????????????5515????????????????5520
Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val
5525????????????????5530????????????????5535
Ile?Arg?Gln?Ala?Leu?Ala?Ser?Gly?Gly?Leu?Ser?Ala?Gly?Asp?Val
5540????????????????5545????????????????5550
Asp?Val?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp?Pro
5555????????????????5560????????????????5565
Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Gly?Arg?Asp
5570????????????????5575????????????????5580
Glu?Glu?Arg?Pro?Leu?Leu?Leu?Gly?Ser?Val?Lys?Ser?Asn?Ile?Gly
5585????????????????5590????????????????5595
His?Thr?Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Val
5600????????????????5605????????????????5610
Met?Ala?Met?Arg?His?Gly?Arg?Leu?Pro?Arg?Thr?Leu?His?Val?Asp
5615????????????????5620????????????????5625
Ala?Pro?Ser?Ser?His?Val?Asp?Trp?Ser?Ala?Gly?Ala?Val?Glu?Leu
5630????????????????5635????????????????5640
Leu?Thr?Gly?Glu?Arg?Val?Trp?Pro?Gly?Glu?Glu?Arg?Leu?Arg?Arg
5645????????????????5650????????????????5655
Ala?Gly?Val?Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr?Asn?Ala?His?Val
5660????????????????5665????????????????5670
Ile?Leu?Glu?Gln?Pro?Glu?Glu?Ala?Gln?Glu?Pro?Ala?Pro?Thr?Val
5675????????????????5680????????????????5685
Ala?Pro?Ala?Val?Asp?Val?Pro?Trp?Val?Leu?Ser?Ala?Arg?Ser?Ala
5690????????????????5695????????????????5700
Pro?Ala?Leu?Arg?Ala?Gln?Ala?Glu?Arg?Leu?Arg?Val?His?Val?Ala
5705????????????????5710????????????????5715
Ala?Glu?Pro?Val?Ser?Ala?Pro?Asp?Val?Ala?Phe?Ser?Leu?Val?Ser
5720????????????????5725????????????????5730
Gly?Arg?Ala?Thr?Phe?Asp?His?Arg?Ala?Val?Val?Leu?Gly?Thr?Asp
5735????????????????5740????????????????5745
Arg?Glu?Ala?Ala?Leu?Glu?Ala?Leu?Ala?Ser?Gly?Leu?Pro?Asp?Ala
5750????????????????5755????????????????5760
Gly?Val?Val?Glu?Gly?Val?Ala?Thr?Gly?Gly?Arg?Thr?Ala?Phe?Leu
5765????????????????5770????????????????5775
Phe?Ser?Gly?Gln?Gly?Ser?Gln?Arg?Leu?Gly?Met?Gly?Arg?Gly?Leu
5780????????????????5785????????????????5790
Tyr?Glu?Arg?Phe?Pro?Val?Phe?Ala?Glu?Ala?Phe?Asp?Ala?Val?Cys
5795????????????????5800????????????????5805
Ala?Gly?Leu?Asp?Glu?His?Leu?Glu?Arg?Pro?Leu?Arg?Glu?Val?Val
5810????????????????5815????????????????5820
Trp?Gly?Asp?Asp?Thr?Ser?Val?Leu?Asp?Gly?Thr?Ala?Tyr?Ala?Gln
5825????????????????5830????????????????5835
Ala?Gly?Leu?Phe?Ala?Val?Glu?Val?Ala?Leu?Phe?Arg?Leu?Val?Glu
5840????????????????5845????????????????5850
Ser?Trp?Gly?Val?Arg?Pro?Glu?Phe?Val?Ala?Gly?His?Ser?Ile?Gly
5855????????????????5860????????????????5865
Glu?Val?Ala?Ala?Ala?His?Val?Ala?Gly?Val?Phe?Thr?Leu?Ala?Asp
5870????????????????5875????????????????5880
Ala?Ala?Ala?Leu?Val?Ala?Ala?Arg?Gly?Arg?Leu?Met?Gln?Ala?Leu
5885????????????????5890????????????????5895
Pro?Glu?Gly?Gly?Ala?Met?Val?Ala?Leu?Glu?Ala?Ser?Glu?Ala?Glu
5900????????????????5905????????????????5910
Val?Leu?Pro?Arg?Leu?Glu?Ser?Val?Glu?Gly?Val?Ser?Val?Ala?Ala
5915????????????????5920????????????????5925
Val?Asn?Gly?Ser?Ser?Ser?Val?Val?Val?Ser?Gly?Ala?Glu?Asp?Ala
5930????????????????5935????????????????5940
Val?Glu?Ala?Val?Ala?Glu?Val?Phe?Arg?Glu?Gln?Gly?Arg?Arg?Val
5945????????????????5950????????????????5955
Ser?Arg?Leu?Arg?Val?Ser?His?Ala?Phe?His?Ser?Pro?Leu?Met?Glu
5960????????????????5965????????????????5970
Pro?Met?Leu?Gly?Asp?Phe?Arg?Glu?Val?Leu?Ser?Gly?Leu?Ser?Tyr
5975????????????????5980????????????????5985
Ala?Glu?Pro?Ser?Leu?Pro?Val?Val?Ser?Asn?Val?Ser?Gly?Arg?Ile
5990????????????????5995????????????????6000
Ala?Glu?Pro?Gly?Glu?Leu?Thr?Thr?Pro?Asp?Tyr?Trp?Val?Thr?His
6005????????????????6010????????????????6015
Val?Arg?Glu?Ala?Val?Arg?Phe?Asp?Asp?Gly?Val?Arg?Ala?Leu?Ala
6020????????????????6025????????????????6030
Glu?Glu?Gly?Val?Thr?Arg?Phe?Val?Glu?Leu?Gly?Pro?Asp?Gly?Val
6035????????????????6040????????????????6045
Leu?Ser?Gly?Met?Ala?Arg?Glu?Gly?Ala?Gly?Glu?Asp?Ala?Val?Leu
6050????????????????6055????????????????6060
Val?Pro?Leu?Leu?Arg?Lys?Asp?Arg?Glu?Glu?Thr?Ser?Thr?Ala?Leu
6065????????????????6070????????????????6075
Ala?Ala?Leu?Ala?Arg?Leu?His?Thr?Val?Gly?Ala?Glu?Val?Lys?Trp
6080????????????????6085????????????????6090
Thr?Gly?Phe?Phe?Ala?Gly?Thr?Ala?Ala?Arg?Thr?Val?Asp?Leu?Pro
6095????????????????6100????????????????6105
Thr?Tyr?Ala?Phe?Gln?Lys?Arg?Arg?Phe?Trp?Pro?Glu?Thr?Thr?Val
6110????????????????6115????????????????6120
Arg?Ala?Ala?Ala?Asp?Pro?Arg?Ser?Ala?Gly?Val?Asp?Ala?Ala?Asp
6125????????????????6130????????????????6135
His?Pro?Leu?Leu?Gly?Ala?Val?Val?Ser?Leu?Pro?Asp?Ser?Gly?Gly
6140????????????????6145????????????????6150
Val?Val?Leu?Thr?Gly?Arg?Leu?Ser?Val?Glu?Ala?Gln?Pro?Trp?Leu
6155????????????????6160????????????????6165
Ala?Asp?His?Val?Val?Leu?Gly?Arg?Val?Leu?Leu?Pro?Gly?Thr?Gly
6170????????????????6175????????????????6180
Leu?Val?Glu?Leu?Ala?Leu?Ala?Ala?Gly?Asp?Ala?Ala?Gly?Ser?Thr
6185????????????????6190????????????????6195
Ala?Leu?Glu?Glu?Leu?Thr?Leu?Ala?Ala?Pro?Leu?Val?Leu?Pro?Glu
6200????????????????6205????????????????6210
Asp?Thr?Gly?Leu?Gln?Leu?Arg?Val?Val?Ala?Gly?Pro?Lys?Thr?Asp
6215????????????????6220????????????????6225
Gly?Arg?Arg?Thr?Val?Ala?Val?His?Ser?Arg?Pro?Glu?Gly?Ala?Glu
6230????????????????6235????????????????6240
Asp?Ala?Pro?Trp?Thr?Ala?His?Ala?His?Gly?Phe?Leu?Thr?Asp?Ala
6245????????????????6250????????????????6255
Pro?Ala?Gly?Ser?Gly?Glu?Ala?Leu?Thr?Glu?Trp?Pro?Pro?Pro?Gly
6260????????????????6265????????????????6270
Ala?Asp?Pro?Val?Pro?Val?Glu?His?Ala?Tyr?Glu?Glu?Phe?Arg?His
6275????????????????6280????????????????6285
Arg?Gly?Tyr?Gly?Tyr?Gly?Pro?Val?Phe?Gln?Gly?Leu?Arg?Ala?Ala
6290????????????????6295????????????????6300
Trp?Arg?Arg?Asp?Asp?Ala?Met?Phe?Ala?Glu?Val?Ala?Leu?Pro?Glu
6305????????????????6310????????????????6315
Asp?Ala?Ala?Gly?Glu?Ala?Gly?Arg?Phe?Gly?Leu?His?Pro?Ala?Val
6320????????????????6325????????????????6330
Leu?Asp?Ala?Ala?Met?His?Ala?Gly?Ile?Leu?Asn?Glu?Glu?Glu?Gly
6335????????????????6340????????????????6345
Gln?Ala?Val?Val?Pro?Phe?Ala?Trp?Asn?Asp?Val?Thr?Leu?His?Ala
6350????????????????6355????????????????6360
Val?Gly?Ala?Ser?Ala?Val?Arg?Val?Arg?Val?Ser?Arg?Val?Asp?Ala
6365????????????????6370????????????????6375
His?Thr?Val?Ser?Leu?Thr?Leu?Ala?Asp?Ser?Thr?Gly?Ala?Pro?Val
6380????????????????6385????????????????6390
Leu?Thr?Val?Gly?Ser?Leu?Ala?Ser?Arg?Pro?Val?Ser?Ala?Glu?Gln
6395????????????????6400????????????????6405
Leu?Gly?Ser?Ala?Ser?Ala?Gly?Ala?Gly?Ala?Leu?Tyr?Gly?Ile?Glu
6410????????????????6415????????????????6420
Trp?Thr?Pro?Val?Thr?Val?Asp?Thr?Ser?Thr?Ala?Pro?Ala?His?Val
6425????????????????6430????????????????6435
Ser?Trp?Ala?Glu?Ala?Leu?Glu?Ala?Asp?Thr?Thr?Ala?Pro?Gly?Ala
6440????????????????6445????????????????6450
Val?Val?Leu?Glu?Val?Arg?Glu?Pro?Ala?Gly?Pro?Asp?Val?Pro?Ala
6455????????????????6460????????????????6465
Ala?Val?Arg?Ala?Val?Leu?Asp?Gln?Val?Leu?Pro?Ala?Ile?Gln?Gln
6470????????????????6475????????????????6480
Trp?Leu?Arg?Asp?Glu?Arg?Phe?Thr?Ser?Ser?Arg?Leu?Val?Val?Val
6485????????????????6490????????????????6495
Thr?Arg?Gly?Ala?Ala?Pro?Ala?Gly?Ser?Ser?Ala?Asp?Val?Val?Gln
6500????????????????6505????????????????6510
Ala?Pro?Val?Trp?Gly?Leu?Val?Arg?Ala?Ala?Leu?Ala?Glu?Asn?Pro
6515????????????????6520????????????????6525
Gly?Arg?Phe?Ala?Leu?Ala?Asp?Val?Ser?Val?Asp?Ala?Asp?Asp?Ala
6530????????????????6535????????????????6540
Ala?Val?Asp?Arg?Ala?Val?Ala?Ala?Ala?Leu?Ser?Gly?Glu?Ala?Glu
6545????????????????6550????????????????6555
Val?Ala?Val?Arg?Asp?Gly?Val?Val?Leu?Val?Pro?Arg?Leu?Ser?Arg
6560????????????????6565????????????????6570
Leu?Ala?Glu?Pro?Glu?Leu?Pro?Leu?Ser?Val?Pro?Ser?Leu?Asp?Gly
6575????????????????6580????????????????6585
Glu?Gly?Ala?Val?Leu?Val?Thr?Gly?Gly?Thr?Gly?Gly?Leu?Gly?Ala
6590????????????????6595????????????????6600
Val?Met?Ala?Arg?Tyr?Leu?Val?Ala?Glu?Arg?Gly?Val?Arg?Asp?Leu
6605????????????????6610????????????????6615
Val?Leu?Val?Ser?Arg?Arg?Gly?Gly?Asp?Ala?Pro?Gly?Ala?Ala?Glu
6620????????????????6625????????????????6630
Leu?Ala?Gly?Glu?Leu?Arg?Glu?Ala?Gly?Ala?Ala?Val?Glu?Val?Val
6635????????????????6640????????????????6645
Ala?Cys?Asp?Leu?Ser?Asp?Arg?Glu?Ser?Val?Val?Gly?Leu?Val?Glu
6650????????????????6655????????????????6660
Ser?Leu?Val?Ala?Gly?Arg?Gly?Leu?Arg?Ala?Val?Val?His?Ala?Ala
6665????????????????6670????????????????6675
Gly?Val?Gly?Gly?Gly?Gly?Leu?Val?Gly?Thr?Leu?Ser?Ser?Asp?Arg
6680????????????????6685????????????????6690
Phe?Asp?Ala?Val?Leu?Gly?Ala?Lys?Ala?Asp?Ala?Ala?Trp?Trp?Leu
6695????????????????6700????????????????6705
His?Glu?Ala?Thr?Ala?Gly?Val?Glu?Leu?Ala?Ala?Phe?Val?Leu?Val
6710????????????????6715????????????????6720
Ser?Ser?Ala?Gly?Gly?Leu?Val?Leu?Thr?Ala?Gly?Gln?Gly?Asn?Tyr
6725????????????????6730????????????????6735
Ala?Ala?Ala?Asn?Val?Phe?Leu?Asp?Ala?Leu?Ala?Ser?Arg?Arg?Arg
6740????????????????6745????????????????6750
Ala?Glu?Gly?Leu?Val?Ala?Thr?Ser?Met?Ala?Phe?Gly?Phe?Trp?Asp
6755????????????????6760????????????????6765
Val?Gly?Ala?Gly?Leu?Gly?Glu?Tyr?Leu?Ser?Glu?Val?Asp?Arg?Arg
6770????????????????6775????????????????6780
Arg?Met?Ala?Ser?Gln?Gly?Leu?Pro?Leu?Leu?Ser?His?Glu?Ala?Gly
6785????????????????6790????????????????6795
Leu?Glu?Leu?Phe?Ala?Ala?Gly?Leu?Asp?Arg?Gly?Glu?Ala?Thr?Val
6800????????????????6805????????????????6810
Val?Pro?Leu?Arg?Val?Asp?Thr?Ala?Ala?Leu?Arg?Thr?Arg?Thr?Asp
6815????????????????6820????????????????6825
Glu?Ile?Pro?Ala?Leu?Leu?Lys?Ser?Leu?Ala?Pro?Val?Arg?Arg?Ser
6830????????????????6835????????????????6840
Ala?Ala?Val?Val?Pro?Pro?Ala?Thr?Val?Glu?Gly?Ser?Pro?Ala?His
6845????????????????6850????????????????6855
Arg?Leu?Ala?Ser?Leu?Pro?Glu?Ala?Glu?Arg?His?Arg?Thr?Leu?Leu
6860????????????????6865????????????????6870
His?Leu?Val?Arg?Ser?Gln?Val?Ala?Ala?Val?Leu?Gly?His?Gly?Ser
6875????????????????6880????????????????6885
Ala?Glu?Ala?Ile?Gly?Ala?Asp?Arg?Ala?Phe?Gln?Glu?Leu?Gly?Phe
6890????????????????6895????????????????6900
Asp?Ser?Leu?Ala?Ala?Thr?Glu?Leu?Arg?Asn?Gln?Leu?Asn?Thr?Leu
6905????????????????6910????????????????6915
Thr?Gly?Leu?Arg?Leu?Pro?Ala?Thr?Leu?Val?Phe?Asp?His?Pro?Asn
6920????????????????6925????????????????6930
Ala?Leu?Ala?Val?Thr?Asp?His?Leu?Ser?Ala?Arg?Leu?Ala?Gly?Glu
6935????????????????6940????????????????6945
Ser?Ala?Arg?Ala?Glu?Thr?Pro?Val?Arg?Thr?Gly?Thr?Ala?Ala?Pro
6950????????????????6955????????????????6960
Ala?Asp?Asp?Glu?Pro?Ile?Ala?Ile?Val?Gly?Met?Ala?Cys?Arg?Tyr
6965????????????????6970????????????????6975
Pro?Gly?Gly?Val?Thr?Thr?Pro?Glu?Glu?Leu?Trp?Arg?Leu?Val?Thr
6980????????????????6985????????????????6990
Asp?Gly?Val?Asp?Thr?Val?Ser?Asp?Leu?Pro?Gly?Asp?Arg?Gly?Trp
6995????????????????7000????????????????7005
Asp?Ile?Glu?Gly?Leu?Tyr?Asp?Pro?Glu?Pro?Gly?Lys?Glu?Gly?Lys
7010????????????????7015????????????????7020
Ser?Tyr?Thr?Arg?Arg?Gly?Ser?Phe?Leu?His?Asp?Ala?Ala?Gln?Phe
7025????????????????7030????????????????7035
Asp?Pro?Gly?Phe?Phe?Gly?Ile?Ser?Pro?Arg?Glu?Ala?Leu?Tyr?Met
7040????????????????7045????????????????7050
Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu?Thr?Ser?Trp?Glu?Ala?Leu
7055????????????????7060????????????????7065
Glu?Arg?Ala?Gly?Ile?Asp?Pro?Ala?Thr?Leu?Arg?Gly?Ser?Arg?Thr
7070????????????????7075????????????????7080
Gly?Val?Phe?Ala?Gly?Val?Met?Tyr?His?Asp?Tyr?Ala?Leu?Asn?Val
7085????????????????7090????????????????7095
Ser?Pro?Ser?Gly?Thr?Ala?Gly?Gly?Ser?Val?Val?Ser?Gly?Arg?Leu
7100????????????????7105????????????????7110
Ser?Tyr?Thr?Phe?Gly?Trp?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp?Thr
7115????????????????7120????????????????7125
Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His?Leu?Ala?Val?Gln?Ala
7130????????????????7135????????????????7140
Leu?Arg?Ser?Gly?Glu?Cys?Ser?Leu?Ala?Val?Ala?Gly?Gly?Ala?Thr
7145????????????????7150????????????????7155
Val?Met?Ser?Thr?Pro?Gly?Met?Phe?Val?Glu?Phe?Ser?Arg?Gln?Arg
7160????????????????7165????????????????7170
Gly?Leu?Ser?Val?Asp?Gly?Arg?Cys?Lys?Ala?Phe?Ala?Gly?Ala?Ala
7175????????????????7180????????????????7185
Asp?Gly?Val?Gly?Trp?Ser?Glu?Gly?Val?Gly?Val?Leu?Leu?Val?Glu
7190????????????????7195????????????????7200
Arg?Leu?Ser?Asp?Ala?Val?Arg?Asn?Gly?His?Arg?Val?Leu?Ala?Val
7205????????????????7210????????????????7215
Val?Lys?Gly?Thr?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly?Phe
7220????????????????7225????????????????7230
Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val?Ile?Arg?Gln?Ala
7235????????????????7240????????????????7245
Leu?His?Gly?Ala?Gly?Val?Pro?Ala?Ser?Glu?Val?Asp?Val?Val?Glu
7250????????????????7255????????????????7260
Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln
7265????????????????7270????????????????7275
Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Asp?Arg?Pro?Glu?Asp?Arg?Pro
7280????????????????7285????????????????7290
Leu?Leu?Leu?Gly?Ser?Val?Lys?Ser?Asn?Ile?Gly?His?Ala?Gln?Ala
7295????????????????7300????????????????7305
Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Val?Met?Ala?Met?Glu
7310????????????????7315????????????????7320
His?Gly?Thr?Val?Pro?Arg?Thr?Leu?His?Val?Asp?Arg?Pro?Ser?Pro
7325????????????????7330????????????????7335
His?Val?Asp?Trp?Thr?Glu?Gly?Arg?Ala?Glu?Leu?Val?Thr?Glu?Asp
7340????????????????7345????????????????7350
Arg?Pro?Trp?Pro?Val?Thr?Gly?Arg?Pro?Arg?Arg?Ala?Ser?Val?Ser
7355????????????????7360????????????????7365
Ala?Phe?Gly?Leu?Ser?Gly?Thr?Asn?Ala?His?Val?Val?Leu?Glu?Gln
7370????????????????7375????????????????7380
Gly?Pro?Asp?Ala?Ala?Ala?Asp?Ala?Pro?Ser?Thr?Ala?Glu?Glu?Gly
7385????????????????7390????????????????7395
Arg?Ala?Pro?Ala?Val?Leu?Pro?Trp?Thr?Val?Ser?Ala?Ala?Thr?Pro
7400????????????????7405????????????????7410
Asp?Ala?Leu?Arg?Ala?Gln?Ala?Thr?Arg?Leu?Leu?Asp?His?Leu?Ala
7415????????????????7420????????????????7425
Asp?Arg?Pro?Gly?Thr?Arg?Pro?Leu?Asp?Val?Ala?His?Ala?Leu?Ala
7430????????????????7435????????????????7440
Thr?Ser?Arg?Thr?Pro?Leu?Glu?Ala?Arg?Ala?Val?Val?Leu?Gly?Thr
7445????????????????7450????????????????7455
Gly?Arg?Asp?Asp?Leu?Leu?Thr?Gly?Leu?Arg?Ala?Leu?Ala?Ala?Gly
7460????????????????7465????????????????7470
Glu?His?Ala?Pro?Gly?Val?Ile?Thr?Gly?Thr?Ala?Arg?Ser?Val?Gly
7475????????????????7480????????????????7485
Thr?Thr?Ala?Phe?Leu?Phe?Ser?Gly?Gln?Gly?Ala?Gln?Arg?Leu?Glu
7490????????????????7495????????????????7500
Met?Gly?Arg?Gly?Leu?His?Glu?Ala?Phe?Pro?Val?Phe?Ala?Glu?Ala
7505????????????????7510????????????????7515
Phe?Asp?Ala?Val?Cys?Ala?Gly?Leu?Asp?Glu?His?Leu?Asp?Arg?Pro
7520????????????????7525????????????????7530
Leu?Arg?Glu?Val?Ala?Trp?Gly?Glu?Asn?Ala?Pro?Asp?Leu?Asp?Gly
7535????????????????7540????????????????7545
Thr?Ala?Tyr?Ala?Gln?Ser?Ala?Leu?Phe?Ala?Tyr?Glu?Val?Ala?Leu
7550????????????????7555????????????????7560
Phe?Arg?Leu?Leu?Ala?Ser?Trp?Gly?Val?Thr?Pro?Asp?Leu?Val?Ala
7565????????????????7570????????????????7575
Gly?His?Ser?Ile?Gly?Glu?Val?Ala?Ala?Ala?His?Val?Ala?Gly?Val
7580????????????????7585????????????????7590
Phe?Ser?Leu?Ala?Asp?Ala?Cys?Ala?Leu?Val?Ala?Ala?Arg?Gly?Arg
7595????????????????7600????????????????7605
Leu?Met?Gln?Ala?Leu?Pro?Glu?Gly?Gly?Ala?Met?Val?Ala?Val?Glu
7610????????????????7615????????????????7620
Ala?Ser?Glu?Thr?Glu?Val?Leu?Pro?His?Leu?Glu?Ser?Val?Glu?Gly
7625????????????????7630????????????????7635
Val?Ser?Val?Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val?Val?Val?Ser
7640????????????????7645????????????????7650
Gly?Ala?Gly?Glu?Ala?Val?Glu?Ala?Val?Ala?Glu?Val?Phe?Arg?Glu
7655????????????????7660????????????????7665
Gln?Gly?Arg?Arg?Val?Ser?Gln?Leu?Arg?Val?Ser?His?Ala?Phe?His
7670????????????????7675????????????????7680
Ser?Pro?Leu?Met?Glu?Pro?Met?Leu?Ala?Asp?Phe?Arg?Glu?Val?Leu
7685????????????????7690????????????????7695
Ser?Gly?Val?Ser?Tyr?Ala?Glu?Pro?Ser?Leu?Pro?Val?Val?Ser?Asn
7700????????????????7705????????????????7710
Val?Ser?Gly?Arg?Ile?Ala?Glu?Ser?Gly?Glu?Leu?Ala?Thr?Pro?Asp
7715????????????????7720????????????????7725
Tyr?Trp?Val?Thr?His?Val?Arg?Glu?Ala?Val?Arg?Phe?Gly?Asp?Gly
7730????????????????7735????????????????7740
Val?Arg?Ala?Leu?Arg?Ala?Ala?Gly?Val?Asp?Arg?Cys?Val?Glu?Ile
7745????????????????7750????????????????7755
Gly?Pro?Asp?Ala?Val?Leu?Thr?Gly?Met?Ala?Arg?Thr?Cys?Leu?Asp
7760????????????????7765????????????????7770
Gly?Asp?Glu?Asp?Thr?Ala?Val?Leu?Leu?Val?Pro?Ser?Ala?Arg?Lys
7775????????????????7780????????????????7785
Gly?Arg?Glu?Glu?Pro?Asp?Ala?Leu?Leu?Thr?Ala?Leu?Ala?Gln?Leu
7790????????????????7795????????????????7800
His?Thr?Ala?Gly?Thr?Ala?Val?Asp?Trp?Ala?Gly?Phe?Phe?Ala?Gly
7805????????????????7810????????????????7815
Ser?Gly?Ala?Gly?Pro?Val?Asp?Leu?Pro?Thr?Tyr?Ala?Phe?Gln?Arg
7820????????????????7825????????????????7830
Gln?Arg?Tyr?Trp?Leu?Thr?Ala?Thr?Asp?Gly?Ala?Pro?Ala?Ala?Ala
7835????????????????7840????????????????7845
Gly?Ala?Gly?Leu?Asp?Ala?Ala?Asp?His?Pro?Leu?Leu?Gly?Ala?Val
7850????????????????7855????????????????7860
Val?Ser?Leu?Pro?Asp?Ser?Gly?Gly?Ala?Val?Leu?Thr?Gly?Leu?Leu
7865????????????????7870????????????????7875
Ser?Val?Glu?Ala?Gln?Pro?Trp?Leu?Ala?Asp?His?Val?Val?Leu?Gly
7880????????????????7885????????????????7890
Arg?Val?Met?Leu?Pro?Gly?Ala?Val?Leu?Val?Glu?Leu?Ala?Leu?Ala
7895????????????????7900????????????????7905
Ala?Gly?Glu?Ser?Val?Asp?Cys?Ala?Val?Leu?Asp?Glu?Leu?Thr?Leu
7910????????????????7915????????????????7920
Ala?Thr?Pro?Leu?Val?Leu?Pro?Glu?His?Gly?Gly?Ala?Gln?Val?Arg
7925????????????????7930????????????????7935
Val?Val?Val?Gly?Pro?Arg?Thr?Ala?Glu?Arg?Arg?Thr?Val?Ala?Val
7940????????????????7945????????????????7950
Tyr?Ser?Arg?Pro?Glu?Gly?Thr?Gly?Gln?Glu?Trp?Ala?Thr?His?Ala
7955????????????????7960????????????????7965
Thr?Gly?Phe?Leu?Thr?Asp?Asn?Ala?Leu?Val?Ala?Gly?Ala?Glu?Ala
7970????????????????7975????????????????7980
Ala?Leu?Glu?Gln?Trp?Pro?Pro?Thr?Gly?Ala?Ala?Ser?Val?Pro?Val
7985????????????????7990????????????????7995
Asp?Ser?Ala?Tyr?Gln?Ile?Phe?Arg?Glu?Arg?Gly?Tyr?Gly?Tyr?Gly
8000????????????????8005????????????????8010
Pro?Val?Phe?Gln?Gly?Leu?Arg?Ala?Ala?Trp?Arg?Arg?Gly?Gly?Glu
8015????????????????8020????????????????8025
Leu?Phe?Ala?Glu?Val?Ala?Leu?Pro?Glu?Glu?Ala?Ala?Ser?Glu?Ala
8030????????????????8035????????????????8040
Gly?Arg?Phe?Gly?Leu?His?Pro?Ala?Leu?Leu?Asp?Ala?Ala?Met?His
8045????????????????8050????????????????8055
Val?Ala?Ile?Leu?Asn?Asp?Ser?Asn?Asp?Ser?Asn?Asp?Ser?Asn?Asp
8060????????????????8065????????????????8070
Asn?Ala?Glu?Gly?Gly?Ser?Gly?Gly?Thr?Val?Ile?Pro?Phe?Ala?Trp
8075????????????????8080????????????????8085
Asn?Arg?Val?Ala?Leu?His?Ala?Val?Gly?Ala?Ala?Ala?Val?Arg?Val
8090????????????????8095????????????????8100
Arg?Ile?Ala?Thr?Ala?Ala?Asp?Gly?Gly?Met?Asp?Ile?Arg?Val?Thr
8105????????????????8110????????????????8115
Asp?Val?Thr?Gly?Ala?Pro?Val?Leu?Thr?Val?Gly?Ser?Met?Val?Ser
8120????????????????8125????????????????8130
Arg?Thr?Val?Ser?Ala?Gly?Gln?Leu?Gly?Ala?Ala?Pro?Arg?Asp?Ala
8135????????????????8140????????????????8145
Gly?Ala?Leu?Tyr?Ala?Pro?Glu?Trp?Val?Pro?Val?Thr?Arg?Leu?Asp
8150????????????????8155????????????????8160
Asp?Thr?Asp?Thr?Ala?Trp?Ala?Thr?Trp?Ser?Arg?Val?Glu?Glu?Ala
8165????????????????8170????????????????8175
Gly?Thr?Glu?Val?Pro?Ala?Val?Val?Val?Leu?Asp?Ala?Ser?Ala?Pro
8180????????????????8185????????????????8190
Ala?Gly?Ala?Asp?Val?Pro?Gly?Ser?Val?Arg?Ser?Ala?Leu?Asp?Gly
8195????????????????8200????????????????8205
Val?Leu?Thr?Val?Ala?Gln?Arg?Trp?Leu?Thr?Glu?Glu?Arg?Phe?Ala
8210????????????????8215????????????????8220
Ala?Ser?Arg?Leu?Val?Val?Val?Thr?Arg?Gly?Ala?Met?Pro?Val?Gly
8225????????????????8230????????????????8235
Ser?Gly?Gly?Ala?Pro?Ala?Glu?Gly?Asp?Val?Val?Gln?Ala?Pro?Val
8240????????????????8245????????????????8250
Trp?Gly?Leu?Val?Arg?Ala?Ala?Leu?Ala?Glu?Asn?Pro?Gly?Arg?Phe
8255????????????????8260????????????????8265
Ala?Leu?Ala?Asp?Val?Ala?Val?Asp?Ala?Asp?Asp?Ala?Ala?Val?Asp
8270????????????????8275????????????????8280
Cys?Ala?Val?Ala?Ala?Val?Leu?Ser?Gly?Glu?Ala?Glu?Val?Ala?Val
8285????????????????8290????????????????8295
Arg?Asp?Gly?Val?Val?Leu?Val?Pro?Arg?Leu?Thr?Arg?Leu?Thr?Ala
8300????????????????8305????????????????8310
Asp?Ala?Pro?Ala?Ala?Glu?Leu?Pro?Leu?Ser?Val?Pro?Ser?Leu?Asp
8315????????????????8320????????????????8325
Gly?Glu?Gly?Ala?Val?Leu?Val?Thr?Gly?Gly?Thr?Gly?Gly?Leu?Gly
8330????????????????8335????????????????8340
Ala?Val?Met?Ala?Arg?Tyr?Leu?Val?Ala?Glu?Arg?Gly?Val?Arg?Asp
8345????????????????8350????????????????8355
Leu?Val?Leu?Val?Ser?Arg?Arg?Gly?Gly?Asp?Ala?Pro?Gly?Ala?Ala
8360????????????????8365????????????????8370
Glu?Leu?Ala?Gly?Glu?Leu?Arg?Glu?Ala?Gly?Ala?Ala?Val?Glu?Val
8375????????????????8380????????????????8385
Val?Ala?Cys?Asp?Leu?Ser?Asp?Arg?Glu?Ser?Val?Val?Asp?Leu?Val
8390????????????????8395????????????????8400
Gly?Ser?Leu?Val?Ser?Gly?Arg?Gly?Leu?Leu?Ala?Val?Val?His?Ala
8405????????????????8410????????????????8415
Ala?Gly?Val?Gly?Asp?Asn?Gly?Leu?Leu?Gly?Ser?Leu?Thr?Pro?Asp
8420????????????????8425????????????????8430
Arg?Phe?Asp?Ala?Val?Leu?Gly?Ala?Lys?Ala?Asp?Ala?Ala?Trp?Trp
8435????????????????8440????????????????8445
Leu?His?Glu?Ala?Thr?Ala?Gly?Val?Glu?Leu?Ala?Ala?Phe?Val?Leu
8450????????????????8455????????????????8460
Val?Ser?Ser?Ala?Gly?Gly?Leu?Val?Leu?Thr?Ala?Gly?Gln?Gly?Asn
8465????????????????8470????????????????8475
Tyr?Ala?Ala?Ala?Asn?Val?Phe?Leu?Asp?Ala?Leu?Ala?Ser?Arg?Arg
8480????????????????8485????????????????8490
Arg?Ala?Glu?Gly?Leu?Val?Ala?Thr?Ser?Met?Ala?Phe?Gly?Phe?Trp
8495????????????????8500????????????????8505
Asp?Val?Gly?Ala?Gly?Leu?Gly?Glu?Tyr?Leu?Ser?Glu?Val?Asp?Arg
8510????????????????8515????????????????8520
Arg?Arg?Met?Ala?Ser?Gln?Gly?Leu?Pro?Leu?Leu?Ser?His?Glu?Ala
8525????????????????8530????????????????8535
Gly?Leu?Glu?Leu?Phe?Ala?Ala?Gly?Leu?Asp?Arg?Ser?Glu?Ala?Thr
8540????????????????8545????????????????8550
Val?Val?Pro?Leu?Arg?Val?Asp?Thr?Ala?Ala?Leu?Arg?Thr?Arg?Thr
8555????????????????8560????????????????8565
Asp?Glu?Ile?Pro?Ala?Leu?Leu?Arg?Ala?Leu?Ala?Pro?Ala?Arg?Arg
8570????????????????8575????????????????8580
Ala?Thr?Ala?Ala?Ser?Gly?Ser?Ala?Ala?Ala?Pro?Gly?Pro?Asp?Asp
8585????????????????8590????????????????8595
Ser?Pro?Ser?Arg?Arg?Leu?Ala?Glu?Leu?Pro?Ala?Pro?Glu?Arg?His
8600????????????????8605????????????????8610
Arg?Ala?Val?Leu?His?Leu?Val?Arg?Ser?Gln?Val?Ala?Ala?Val?Leu
8615????????????????8620????????????????8625
Gly?His?Gly?Ser?Ala?Glu?Ala?Ile?Gly?Ala?Asp?Arg?Ala?Phe?Gln
8630????????????????8635????????????????8640
Glu?Leu?Gly?Phe?Asp?Ser?Leu?Ala?Ala?Thr?Glu?Leu?Arg?Asn?Gln
8645????????????????8650????????????????8655
Leu?Asn?Thr?Leu?Thr?Gly?Leu?Arg?Leu?Pro?Ala?Thr?Leu?Val?Phe
8660????????????????8665????????????????8670
Asp?His?Pro?Asn?Ala?Leu?Ala?Val?Thr?Glu?Val?Val?Glu?Glu?Glu
8675????????????????8680????????????????8685
Leu?Ala?Ala?Ala?His?Pro?Ala?Ser?Gly?Ala?Gly?Gly?Ala?Thr?Gly
8690????????????????8695????????????????8700
Asp?Asp?Asp?Gly?Val?Arg?Arg?Ala?Leu?Ser?Ala?Ile?Pro?Ala?Arg
8705????????????????8710????????????????8715
Arg?Leu?Arg?Asp?Ala?Gly?Leu?Ala?Glu?Thr?Leu?Leu?Glu?Leu?Ala
8720????????????????8725????????????????8730
Ala?Asp?Ser?Asp?Glu?Met?Ser?Asp?Thr?Asp?Arg?Asp?Ala?Leu?Leu
8735????????????????8740????????????????8745
Ala?Ala?Phe?Asp?Gly?Asp?Asp?Glu?Asp?Asp?Ala?Ser?Gly?Pro?Tyr
8750????????????????8755????????????????8760
Asp?Glu?Ser?Asp?Gly?Ala?Ala?Glu?Thr?Ala?Gly?Thr?Gly?Thr?Ala
8765????????????????8770????????????????8775
Thr?Glu?Pro?Gly?Ala?Asp?Ala?Leu?Arg?Ala?Ala?Arg?Ala?Glu?Thr
8780????????????????8785????????????????8790
Ala?Arg?Leu?Arg?Arg?Asp?Asn?Arg?Arg?Leu?Thr?Ser?Ala?Gln?His
8795????????????????8800????????????????8805
Glu?Pro?Ile?Ala?Ile?Val?Gly?Met?Ala?Cys?Arg?Tyr?Pro?Gly?Gly
8810????????????????8815????????????????8820
Val?Ser?Ser?Pro?Glu?Asp?Leu?Trp?Arg?Leu?Val?Thr?Ser?Gly?Asp
8825????????????????8830????????????????8835
Asp?Ala?Ile?Val?Pro?Phe?Pro?Gln?Asp?Arg?Gly?Trp?Asp?Leu?Ser
8840????????????????8845????????????????8850
Ile?Leu?Arg?Asp?Pro?Asp?Gly?Asp?His?Pro?Asp?Gly?Leu?Tyr?Ala
8855????????????????8860????????????????8865
Arg?Glu?Gly?Gly?Phe?Leu?Asp?Gly?Ala?Ala?Asp?Phe?Asp?Pro?Ala
8870????????????????8875????????????????8880
Phe?Phe?Gly?Ile?Ser?Pro?Arg?Glu?Ala?Leu?Gly?Met?Asp?Pro?Gln
8885????????????????8890????????????????8895
Gln?Arg?Leu?Ala?Leu?Glu?Met?Ser?Trp?Glu?Ala?Leu?Glu?Arg?Ala
8900????????????????8905????????????????8910
Gly?Ile?Asp?Pro?Ala?Ser?Leu?Lys?Gly?Ser?Arg?Thr?Gly?Val?Phe
8915????????????????8920????????????????8925
Thr?Gly?Val?Met?Tyr?His?Asp?Tyr?Pro?Gly?Ser?Asp?Gly?Asn?Gly
8930????????????????8935????????????????8940
Ser?Val?Val?Thr?Gly?Arg?Val?Ala?Tyr?Lys?Leu?Gly?Leu?Glu?Gly
8945????????????????8950????????????????8955
Pro?Ala?Val?Ser?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala
8960????????????????8965????????????????8970
Leu?His?Leu?Ala?Val?Gln?Ala?Leu?Arg?Gln?Gly?Glu?Cys?Ser?Leu
8975????????????????8980????????????????8985
Ala?Val?Thr?Gly?Gly?Val?Thr?Val?Leu?Ser?Thr?Pro?Ala?Val?Phe
8990????????????????8995????????????????9000
Ala?Glu?Phe?Gly?Arg?Gln?Gly?Gly?Leu?Ala?Pro?Asp?Gly?Arg?Cys
9005????????????????9010????????????????9015
Lys?Ser?Phe?Ala?Ser?Ala?Ala?Asp?Gly?Thr?Gly?Phe?Ser?Glu?Gly
9020????????????????9025????????????????9030
Ala?Gly?Phe?Leu?Val?Val?Glu?Arg?Leu?Ser?Asp?Ala?Val?Arg?Asn
9035????????????????9040????????????????9045
Gly?His?Glu?Val?Leu?Ala?Val?Val?Arg?Gly?Ser?Ala?Val?Asn?Gln
9050????????????????9055????????????????9060
Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln
9065????????????????9070????????????????9075
Arg?Arg?Val?Ile?Arg?Gln?Ala?Leu?Ala?Asn?Ala?Arg?Leu?Ala?Ala
9080????????????????9085????????????????9090
Asp?Gln?Val?Asp?Ala?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu
9095????????????????9100????????????????9105
Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln
9110????????????????9115????????????????9120
Asp?Arg?Pro?Glu?Asp?Arg?Pro?Leu?Leu?Leu?Gly?Ser?Val?Lys?Ser
9125????????????????9130????????????????9135
Asn?Ile?Gly?His?Ala?Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Ile
9140????????????????9145????????????????9150
Lys?Met?Val?Leu?Ala?Leu?Arg?Asn?Gly?Leu?Leu?Pro?Ala?Thr?Leu
9155????????????????9160????????????????9165
Asn?Val?Asp?Ala?Pro?Ser?Asp?Gln?Val?Asp?Trp?Thr?Thr?Gly?Ser
9170????????????????9175????????????????9180
Val?Glu?Leu?Leu?Thr?Glu?Ala?Arg?Gln?Trp?Thr?Gly?Ser?Gly?Arg
9185????????????????9190????????????????9195
Pro?Arg?Arg?Ala?Gly?Ile?Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr?Asn
9200????????????????9205????????????????9210
Ala?His?Val?Ile?Val?Glu?Gln?Ala?Pro?Ala?Ala?Val?Pro?Ser?Asp
9215????????????????9220????????????????9225
Glu?Pro?Ala?Thr?Gly?Ala?Asp?Asp?Asp?Gly?Val?Ala?Pro?Val?Val
9230????????????????9235????????????????9240
Pro?Trp?Leu?Leu?Ser?Ala?Arg?Asp?Arg?Asp?Ala?Leu?Arg?Ala?Gln
9245????????????????9250????????????????9255
Ala?Glu?Arg?Leu?Leu?His?His?Leu?Thr?Gly?Asp?His?Pro?Ala?Ala
9260????????????????9265????????????????9270
Gly?Gly?Thr?Glu?Ala?Arg?Pro?Leu?Asp?Val?Ala?Tyr?Ser?Leu?Ala
9275????????????????9280????????????????9285
Thr?Ala?Arg?Thr?Ala?Phe?Glu?His?Arg?Val?Ala?Val?Thr?Gly?Ala
9290????????????????9295????????????????9300
Gly?Arg?Asp?Gly?Leu?Leu?Ala?Ala?Leu?Gly?Ser?Val?Ala?Arg?Gly
9305????????????????9310????????????????9315
Glu?Glu?Pro?Ala?Thr?Thr?Thr?Gly?Glu?Gly?Leu?Leu?Ala?Leu?Leu
9320????????????????9325????????????????9330
Phe?Pro?Gly?Gln?Gly?Ser?Gln?Arg?Leu?Gly?Met?Gly?Arg?Asp?Leu
9335????????????????9340????????????????9345
Tyr?Glu?Arg?Phe?Pro?Val?Phe?Ala?Glu?Ala?Phe?Asp?Ala?Val?Cys
9350????????????????9355????????????????9360
Ala?Gly?Leu?Asp?Ala?His?Leu?Asp?Arg?Pro?Leu?Arg?Glu?Val?Val
9365????????????????9370????????????????9375
Trp?Gly?Asp?Asp?Glu?Asp?Ala?Leu?Asn?Ala?Thr?Ala?Tyr?Ala?Gln
9380????????????????9385????????????????9390
Ala?Ala?Leu?Phe?Ala?Leu?Gly?Val?Gly?Leu?His?Arg?Leu?Val?Ala
9395????????????????9400????????????????9405
Ser?Trp?Gly?Val?Thr?Pro?Asp?Leu?Val?Ala?Gly?His?Ser?Ile?Gly
9410????????????????9415????????????????9420
Glu?Ile?Ala?Ala?Ala?His?Val?Ala?Gly?Val?Phe?Ser?Leu?Ala?Asp
9425????????????????9430????????????????9435
Ala?Cys?Ala?Leu?Val?Ala?Ala?Arg?Gly?Arg?Leu?Met?Gln?Ala?Leu
9440????????????????9445????????????????9450
Pro?Glu?Gly?Gly?Ala?Met?Ala?Ala?Val?Gln?Ala?Thr?Glu?Asp?Glu
9455????????????????9460????????????????9465
Val?Leu?Ala?His?Leu?Thr?Asp?Gly?Val?Ser?Val?Ala?Ala?Val?Asn
9470????????????????9475????????????????9480
Gly?Pro?Thr?Ser?Val?Val?Val?Ser?Gly?Thr?Ala?Glu?Gly?Val?Glu
9485????????????????9490????????????????9495
Lys?Val?Thr?Glu?Ala?Leu?Arg?Glu?Arg?Gly?Arg?Arg?Thr?Thr?Ala
9500????????????????9505????????????????9510
Leu?Arg?Val?Ser?His?Ala?Phe?His?Ser?Pro?Leu?Met?Glu?Pro?Met
9515????????????????9520????????????????9525
Leu?Ala?Glu?Phe?Arg?Ala?Val?Val?Ala?Gly?Leu?Ser?Pro?Gln?Ala
9530????????????????9535????????????????9540
Pro?Val?Ile?Pro?Val?Val?Ser?Asn?Leu?Thr?Gly?Thr?Thr?Ala?Arg
9545????????????????9550????????????????9555
Ala?Glu?Glu?Leu?Cys?Ser?Ala?Glu?Tyr?Trp?Val?Arg?His?Val?Arg
9560????????????????9565????????????????9570
Glu?Ala?Val?Arg?Phe?Ala?Asp?Gly?Val?Arg?Ala?Leu?His?Glu?Ala
9575????????????????9580????????????????9585
Gly?Ala?Thr?Arg?Tyr?Leu?Glu?Leu?Gly?Pro?Asp?Gly?Val?Ala?Cys
9590????????????????9595????????????????9600
Ala?Met?Ala?Arg?Glu?Ser?Leu?Pro?Glu?Ser?Ala?Val?Thr?Val?Ala
9605????????????????9610????????????????9615
Ala?Gln?Arg?Arg?Thr?Val?Pro?Gly?Glu?Gln?Ala?Leu?Val?Glu?Ala
9620????????????????9625????????????????9630
Val?Ala?Arg?Leu?His?Gly?His?Gly?Val?Arg?Val?Asp?Trp?Pro?Ala
9635????????????????9640????????????????9645
Phe?Phe?Ala?Gly?Arg?Gly?Ala?Arg?Arg?Val?Glu?Leu?Pro?Thr?Tyr
9650????????????????9655????????????????9660
Ala?Phe?Gln?Arg?Arg?Arg?Phe?Trp?Pro?Ala?Gly?Met?Met?Pro?Leu
9665????????????????9670????????????????9675
Gly?Ala?Gly?Ala?Glu?Ala?Ala?Gly?Leu?Ala?Pro?Ala?Gly?His?Pro
9680????????????????9685????????????????9690
Leu?Leu?Gly?Gly?Ala?Val?Glu?Leu?Ala?Gly?Thr?Asp?Gly?His?Leu
9695????????????????9700????????????????9705
Phe?Thr?Gly?Arg?Leu?Ser?Gln?Gly?Thr?His?Gly?Trp?Ile?Ser?Asp
9710????????????????9715????????????????9720
His?Arg?Val?Met?Gly?Ala?Val?Leu?Val?Pro?Gly?Thr?Ala?Leu?Leu
9725????????????????9730????????????????9735
Glu?Leu?Ala?Val?His?Ala?Gly?Gly?Val?Leu?Gly?Cys?Asp?Val?Val
9740????????????????9745????????????????9750
Glu?Glu?Leu?Thr?Leu?Ala?Ala?Pro?Leu?Val?Leu?Pro?Glu?Gln?Gly
9755????????????????9760????????????????9765
Thr?Val?Gln?Val?Gln?Val?Gly?Val?Gly?Ala?Pro?Asp?Glu?Glu?Gly
9770????????????????9775????????????????9780
Arg?Arg?Gly?Ile?Thr?Ile?His?Ser?Arg?Pro?Ala?Asp?Asp?Ser?Gly
9785????????????????9790????????????????9795
Ala?Pro?Trp?Thr?Ser?His?Ala?Glu?Gly?Thr?Leu?Ala?Ala?Gly?Pro
9800????????????????9805????????????????9810
Ala?Gln?Ala?Pro?Ala?Thr?Asp?Phe?Asp?Ala?Thr?Val?Trp?Pro?Pro
9815????????????????9820????????????????9825
Glu?Lys?Ala?Glu?Pro?Leu?Asp?Thr?Thr?Gly?Leu?Tyr?Glu?Arg?Phe
9830????????????????9835????????????????9840
Glu?Asp?Ala?Gly?Phe?Ala?Tyr?Gly?Pro?Val?Phe?Gln?Gly?Leu?Arg
9845????????????????9850????????????????9855
Ala?Ala?Trp?Ser?Arg?Asp?Gly?Glu?Val?Phe?Ala?Glu?Ala?Ser?Leu
9860????????????????9865????????????????9870
Pro?Asp?Gly?Thr?Asp?Gly?Asp?Ala?Phe?Thr?Leu?His?Pro?Ala?Leu
9875????????????????9880????????????????9885
Phe?Asp?Ala?Gly?Leu?His?Ala?Thr?Ala?Leu?Ala?Gly?Asp?Gly?Gly
9890????????????????9895????????????????9900
Glu?Ser?Glu?Gly?Thr?Gly?Gly?Val?Pro?Phe?Ser?Trp?Asn?Gly?Val
9905????????????????9910????????????????9915
Ser?Val?His?Ala?Val?Gly?Ala?Ser?Ser?Val?Arg?Leu?Arg?Leu?Ser
9920????????????????9925????????????????9930
Arg?Thr?Asp?Asp?Gly?Thr?Leu?Ala?Ile?Ala?Val?Thr?Asp?Thr?Ala
9935????????????????9940????????????????9945
Gly?Thr?Pro?Val?Ala?Ser?Val?Gly?Ser?Leu?Val?Thr?Arg?Pro?Leu
9950????????????????9955????????????????9960
Ser?Ala?Gly?Gln?Phe?Gly?Gly?Ala?Gly?Gly?Ala?Gly?Arg?Asp?Ser
9965????????????????9970????????????????9975
Leu?Phe?Gln?Leu?Asp?Trp?Ala?Ala?Ala?Gly?Asp?Pro?Ala?Thr?Arg
9980????????????????9985????????????????9990
Asp?Ala?Glu?Thr?Pro?Gly?Pro?Val?Ala?Val?Leu?Gly?Pro?Asp?Thr
9995????????????????10000???????????????10005
Ala?Leu?Leu?Gly?Gly?Gly?Asp?Leu?Leu?Ala?Glu?Ala?Gly?Thr?Glu
10010???????????????10015???????????????10020
Gly?Val?Thr?Gly?Leu?Ala?Asp?Leu?Val?Thr?Gly?Thr?Gly?Pro?Gly
10025???????????????10030???????????????10035
Glu?Asp?Val?Pro?Ser?Val?Val?Leu?Leu?Pro?Val?Ala?Thr?Ala?Pro
10040???????????????10045???????????????10050
Glu?Ala?Gly?Ser?Gly?Thr?Gly?Asp?Val?Ala?Ala?Ala?Ala?His?Ala
10055???????????????10060???????????????10065
Ala?Thr?Ala?Arg?Val?Leu?Glu?Thr?Leu?Arg?Asp?Trp?Ser?Ala?Gln
10070???????????????10075???????????????10080
Glu?Arg?Phe?Ala?Ala?Ser?Arg?Leu?Val?Val?Val?Thr?Arg?Gly?Ala
10085???????????????10090???????????????10095
Ser?Asp?Gly?Ala?Asp?Pro?Ala?Ala?Ala?Ala?Val?Trp?Gly?Leu?Val
10100???????????????10105???????????????10110
Arg?Ala?Ala?Gln?Ala?Glu?Asn?Pro?Gly?Arg?Phe?Ile?Leu?Leu?Asp
10115???????????????10120???????????????10125
Leu?Glu?Pro?Ser?Ala?Thr?Ser?Pro?Leu?Gly?Met?Ser?Ala?Leu?Arg
10130???????????????10135???????????????10140
Ala?Ala?Leu?Ala?Ser?Gly?Glu?Pro?Gln?Leu?Ala?Leu?Arg?Glu?Asp
10145???????????????10150???????????????10155
Arg?Leu?Leu?Ala?Pro?Arg?Leu?Val?Arg?Ala?Val?Thr?Pro?Ala?Glu
10160???????????????10165???????????????10170
Ser?Asp?Ala?Ala?Gly?Trp?Asp?Pro?Glu?Gly?Thr?Val?Leu?Ile?Thr
10175???????????????10180???????????????10185
Gly?Gly?Thr?Gly?Gly?Leu?Gly?Ala?Thr?Val?Ala?Arg?His?Leu?Val
10190???????????????10195???????????????10200
Ala?Glu?His?Gly?Val?Arg?Ser?Leu?Leu?Leu?Val?Ser?Arg?Arg?Gly
10205???????????????10210???????????????10215
Pro?Ala?Ala?Glu?Gly?Ala?Gly?Glu?Leu?Ala?Ala?Ala?Leu?Glu?Glu
10220???????????????10225???????????????10230
Ser?Gly?Ala?His?Val?Thr?Val?Ala?Ala?Cys?Asp?Val?Gly?Asp?Arg
10235???????????????10240???????????????10245
Thr?Ala?Val?Asp?Ala?Leu?Leu?Ala?Glu?Ile?Pro?Ala?Asp?Arg?Pro
10250???????????????10255???????????????10260
Leu?Arg?Ala?Val?lle?His?Ala?Ala?Gly?Val?Leu?Asp?Asp?Gly?Val
10265???????????????10270???????????????10275
Leu?Asp?Ser?Leu?Thr?Pro?Glu?Arg?Leu?Ala?Ala?Val?Leu?Arg?Pro
10280???????????????10285???????????????10290
Lys?Ala?Asp?Ala?Ala?Trp?His?Leu?His?Glu?Ala?Thr?Glu?Gly?Leu
10295???????????????10300???????????????10305
Thr?Leu?Asp?Ala?Phe?Val?Leu?Phe?Ser?Ser?Val?Ala?Gly?Thr?Leu
10310???????????????10315???????????????10320
Gly?Ser?Ala?Gly?Gln?Ala?Asn?Tyr?Ala?Ala?Gly?Asn?Ala?Phe?Leu
10325???????????????10330???????????????10335
Asp?Ala?Leu?Ala?Arg?His?Arg?Arg?Asp?Arg?Gly?Leu?Pro?Ala?Val
10340???????????????10345???????????????10350
Ser?Met?Ala?Trp?Gly?Pro?Trp?Thr?Arg?Gly?Ser?Gly?Met?Thr?Gly
10355???????????????10360???????????????10365
Glu?Leu?Thr?Glu?Ala?Asp?Thr?Ala?Arg?Met?Ala?Arg?Ala?Gly?Met
10370???????????????10375???????????????10380
Pro?Pro?Ile?Asp?Pro?Glu?Gln?Gly?Leu?Ala?Leu?Phe?Asp?Ala?Val
10385???????????????10390???????????????10395
Thr?Gly?Ala?Ala?Glu?Gln?Ala?Pro?Ala?Val?Leu?Pro?Val?Arg?Leu
10400???????????????10405???????????????10410
Asp?Leu?Gly?Ala?Leu?Arg?Ser?Leu?Gly?Glu?Val?Pro?Pro?Leu?Phe
10415???????????????10420???????????????10425
Arg?Ser?Leu?Ile?Arg?Thr?Gln?Ala?Arg?Arg?Ala?Ala?Ser?Asp?Gly
10430???????????????10435???????????????10440
Gly?Ala?Ala?Ala?Ala?Ala?Asp?Leu?Thr?Arg?Arg?Leu?Thr?Gly?Leu
10445???????????????10450???????????????10455
Thr?Arg?Thr?Glu?Gly?Glu?Glu?Val?Leu?Leu?Asp?Leu?Val?Arg?Gly
10460???????????????10465???????????????10470
Gln?Ile?Ala?Thr?Val?Leu?Gly?His?Ala?Gly?Gln?Ala?Asp?Ile?Glu
10475???????????????10480???????????????10485
Pro?Ala?Arg?Ala?Phe?Gln?Asp?Leu?Gly?Phe?Asp?Ser?Leu?Thr?Ser
10490???????????????10495???????????????10500
Val?Glu?Leu?Arg?Asn?Arg?Leu?Gly?Ala?Leu?Thr?Gly?Val?Arg?Leu
10505???????????????10510???????????????10515
Pro?Ala?Thr?Leu?Leu?Phe?Asp?Tyr?Pro?Thr?Pro?Gly?Glu?Leu?Val
10520???????????????10525???????????????10530
Ala?His?Leu?Tyr?Thr?Arg?Val?Ala?Pro?Ala?Pro?Ala?Asp?Gly?Ser
10535???????????????10540???????????????10545
Ala?Val?Val?Leu?Ala?Glu?Leu?Asp?Lys?Leu?Glu?Arg?Ala?Phe?Ala
10550???????????????10555???????????????10560
Gly?Ala?Glu?Val?Gly?Ala?Glu?Leu?Phe?Asp?Gln?Val?Ala?Gly?Arg
10565???????????????10570???????????????10575
Leu?Glu?Val?Leu?Arg?Gly?Lys?Trp?Gln?Glu?Met?Arg?Ala?Glu?Ala
10580???????????????10585???????????????10590
Leu?Lys?Gly?Gly?Glu?Lys?Ala?Glu?Glu?Ser?Phe?Asp?Phe?Ala?Ser
10595???????????????10600???????????????10605
Ala?Ser?Asp?Glu?Asp?Met?Phe?Asp?Met?Leu?Asp?Asn?Glu?Leu?Gly
10610???????????????10615???????????????10620
Leu?Ser
10625
<210>4
<211>5541
<212>PRT
＜213〉streptomycete FR-008
<400>4
Met?Ser?Asn?Glu?Asp?Arg?Leu?Arg?Ala?Tyr?Leu?Lys?Arg?Ala?Val?Thr
1???????????????5???????????????????10??????????????????15
Asp?Leu?Gln?Glu?Ala?Arg?Gln?Gln?Leu?Ser?Asp?Ala?Glu?Asn?Arg?Asp
20??????????????????25??????????????????30
Arg?Glu?Pro?Val?Ala?Val?Val?Ala?Met?Ala?Cys?Arg?Tyr?Pro?Gly?Gly
35??????????????????40??????????????????45
Val?Arg?Thr?Pro?Gln?Asp?Leu?Trp?Glu?Leu?Ala?Arg?Asp?Gly?Val?Asp
50??????????????????55??????????????????60
Ala?Ile?Ser?Ala?Phe?Pro?Ala?Asn?Arg?Gly?Trp?Asp?Leu?Asp?His?Leu
65??????????????????70??????????????????75??????????????????80
Phe?His?Pro?Asp?Pro?Ala?His?His?Gly?Thr?Thr?Tyr?Thr?Arg?Glu?Gly
85??????????????????90??????????????????95
Gly?Phe?Leu?His?Asp?Ala?Gly?Glu?Phe?Asp?Pro?Ala?Phe?Phe?Gly?Ile
100?????????????????105?????????????????110
Ser?Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu
115?????????????????120?????????????????125
Glu?Thr?Ser?Trp?Glu?Ala?Leu?Glu?Arg?Ala?Gly?Ile?Leu?Pro?Asp?Thr
130?????????????????135?????????????????140
Leu?Ala?Gly?Ser?Thr?Thr?Gly?Val?Phe?Val?Gly?Thr?Gly?His?Gly?Asp
145?????????????????150?????????????????155?????????????????160
Tyr?Asp?Gly?Ala?Ser?Arg?Gly?Arg?Gln?Lys?Glu?Val?Ala?Gly?His?Leu
165?????????????????170?????????????????175
Leu?Thr?Gly?Asn?Thr?Val?Ala?Val?Ala?Ser?Gly?Arg?Leu?Ser?Tyr?Thr
180?????????????????185?????????????????190
Tyr?Gly?Phe?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser
195?????????????????200?????????????????205
Ser?Leu?Val?Ala?Leu?His?Leu?Ala?Val?Arg?Ser?Leu?Arg?Gln?Gly?Glu
210?????????????????215?????????????????220
Cys?Ser?Leu?Ala?Leu?Ala?Gly?Gly?Ala?Thr?Val?Met?Ser?Thr?Pro?Lys
225?????????????????230?????????????????235?????????????????240
Met?Phe?Thr?Glu?Phe?Ser?Arg?Gln?Gln?Gly?Leu?Ala?Ala?Asp?Gly?Arg
245?????????????????250?????????????????255
Cys?Lys?Pro?Phe?Ala?Ala?Gly?Ala?Asp?Gly?Thr?Ala?Trp?Ser?Glu?Gly
260?????????????????265?????????????????270
Val?Gly?Leu?Ile?Leu?Leu?Glu?Arg?Leu?Ser?Asp?Ala?Gln?Arg?Asn?Gly
275?????????????????280?????????????????285
His?Glu?Ile?Leu?Ala?Val?Ile?Arg?Gly?Ser?Ala?Ile?Asn?Gln?Asp?Gly
290?????????????????295?????????????????300
Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Leu
305?????????????????310?????????????????315?????????????????320
Ile?Arg?Gln?Ala?Leu?Ile?Asp?Ala?Gly?Leu?Thr?Ser?Gly?Glu?Val?Asp
325?????????????????330?????????????????335
Val?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp?Pro?Ile?Glu
340?????????????????345?????????????????350
Ala?Gln?Ala?Leu?Leu?Asn?Thr?Tyr?Gly?Gln?Asp?Arg?Gly?Asp?Ala?His
355?????????????????360?????????????????365
Pro?Leu?Leu?Leu?Gly?Ser?Leu?Lys?Ser?Asn?Thr?Gly?His?Thr?Gln?Ala
370?????????????????375?????????????????380
Ala?Ser?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Val?Gln?Ala?Met?Arg?His
385?????????????????390?????????????????395?????????????????400
Gly?Thr?Leu?Pro?Lys?Ser?Leu?His?Val?Asp?Ala?Pro?Thr?Pro?His?Ala
405?????????????????410?????????????????415
Asp?Trp?Ala?Thr?Gly?Gly?Val?Glu?Leu?Leu?Thr?Glu?Ser?Thr?Thr?Trp
420?????????????????425?????????????????430
Pro?Glu?Thr?Gly?Arg?Pro?Arg?Arg?Ala?Ala?Val?Ser?Ser?Phe?Gly?Val
435?????????????????440?????????????????445
Ser?Gly?Thr?Asn?Ala?His?Leu?Ile?Leu?Glu?Gln?Ala?Pro?Glu?Asp?Gln
450?????????????????455?????????????????460
Thr?Pro?Arg?Ala?Glu?Glu?Pro?Gly?Thr?Glu?Pro?Ser?Ala?Asp?Asp?Ser
465?????????????????470?????????????????475?????????????????480
Ala?Asp?Thr?Val?Arg?Ser?Trp?Met?Val?Ser?Gly?Lys?Ser?Arg?Ala?Ala
485?????????????????490?????????????????495
Val?Gly?Glu?Gln?Ala?Ala?Arg?Leu?Ala?Ala?Ser?Val?Arg?Ala?Ser?Asp
500?????????????????505?????????????????510
Ala?Ser?Val?Leu?Asp?Val?Ala?His?Ala?Leu?Val?Ser?Ser?Arg?Val?Ala
515?????????????????520?????????????????525
Met?Asp?Arg?Arg?Ala?Val?Val?Val?Gly?Ser?Asp?Arg?Glu?Glu?Leu?Leu
530?????????????????535?????????????????540
Ala?Gly?Leu?Asp?Ala?Leu?Ala?Ala?Gly?Glu?Pro?Ser?Val?Arg?Val?Val
545?????????????????550?????????????????555?????????????????560
Glu?Gly?Thr?Ala?Gly?Glu?Gly?Ala?Gly?Asp?Val?Ala?Phe?Val?Phe?Pro
565?????????????????570?????????????????575
Gly?Gln?Gly?Ser?Gln?Trp?Val?Gly?Met?Ala?Val?Glu?Leu?Leu?Gly?Ser
580?????????????????585?????????????????590
Ser?Pro?Val?Phe?Ala?Gly?Arg?Val?Ala?Glu?Cys?Ala?Ala?Ala?Leu?Glu
595?????????????????600?????????????????605
Pro?Phe?Thr?Glu?Trp?Ser?Leu?Leu?Asp?Val?Leu?Asn?Gly?Val?Glu?Gly
610?????????????????615?????????????????620
Ala?Ala?Ser?Leu?Glu?Arg?Val?Asp?Val?Val?Gln?Pro?Val?Leu?Trp?Ala
625?????????????????630?????????????????635?????????????????640
Val?Met?Val?Ser?Leu?Ala?Glu?Val?Trp?Arg?Ala?Gln?Gly?Val?Glu?Pro
645?????????????????650?????????????????655
Gly?Ala?Val?Ile?Gly?His?Ser?Gln?Gly?Glu?Ile?Ala?Ala?Ala?Val?Val
660?????????????????665?????????????????670
Ala?Gly?Gly?Leu?Ser?Leu?Glu?Asp?Gly?Ala?Arg?Val?Val?Ala?Leu?Arg
675?????????????????680?????????????????685
Ser?Arg?Ala?Leu?Arg?Ala?Leu?Ser?Gly?Leu?Gly?Gly?Met?Val?Ser?Val
690?????????????????695?????????????????700
Ala?Arg?Asn?Val?Asp?Glu?Val?Arg?Gly?Leu?Leu?Ala?Gly?Trp?Glu?Gly
705?????????????????710?????????????????715?????????????????720
Arg?Ile?Ser?Val?Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val?Val?Val?Ser
725?????????????????730?????????????????735
Gly?Asp?Ala?Glu?Ala?Leu?Asp?Glu?Phe?Val?Ala?Ala?Cys?Asp?Ala?Ser
740?????????????????745?????????????????750
Gly?Val?Arg?Ala?Arg?Arg?Val?Ala?Val?Asp?Tyr?Ala?Ser?His?Ser?Ala
755?????????????????760?????????????????765
His?Val?Glu?Arg?Ile?Glu?Glu?Glu?Leu?Ala?Gly?Leu?Leu?Ala?Pro?Val
770?????????????????775?????????????????780
Ala?Pro?Arg?Ser?Cys?Asp?Val?Pro?Phe?Tyr?Ser?Thr?Leu?Ser?Gly?Gly
785?????????????????790?????????????????795?????????????????800
Val?Ile?Asp?Thr?Ala?Gly?Leu?Asp?Ala?Gly?Tyr?Trp?Tyr?Arg?Asn?Leu
805?????????????????810?????????????????815
Arg?Gly?Thr?Val?Glu?Phe?Glu?Ala?Gly?Thr?Arg?Ala?Leu?Leu?Ala?Asp
820?????????????????825?????????????????830
Gly?Phe?Arg?Val?Phe?Val?Glu?Val?Ser?Ala?His?Pro?Val?Val?Ala?Thr
835?????????????????840?????????????????845
Gly?Val?Gln?Glu?Thr?Ile?Glu?Asp?Ala?Ser?Val?Gln?Ala?Gly?Val?Val
850?????????????????855?????????????????860
Gly?Thr?Leu?Arg?Arg?Asp?Glu?Gly?Gly?Leu?Glu?Arg?Phe?Ala?Leu?Ser
865?????????????????870?????????????????875?????????????????880
Leu?Gly?Glu?Ala?Trp?Ala?Leu?Gly?Ala?Glu?Val?Asp?Trp?Glu?Thr?His
885?????????????????890?????????????????895
Tyr?Ala?Gly?Thr?Arg?Pro?Arg?His?Val?Asp?Leu?Pro?Thr?Tyr?Pro?Phe
900?????????????????905?????????????????910
Arg?Arg?Asp?Trp?Tyr?Trp?Leu?Thr?Pro?Ala?Glu?Ser?Ala?Ala?Ala?Ala
915?????????????????920?????????????????925
Ala?Thr?Gly?Asp?Pro?Ala?Asp?Gly?Asp?Phe?Trp?Ser?Ala?Val?Glu?Ser
930?????????????????935?????????????????940
Gly?Asp?Leu?Thr?Arg?Leu?Ser?Ser?Val?Leu?Glu?Val?Thr?Gly?Asp?Asp
945?????????????????950?????????????????955?????????????????960
Val?Glu?Ala?Phe?Gly?Thr?Leu?Leu?Pro?Ala?Leu?Ala?Ser?Trp?Arg?Arg
965?????????????????970?????????????????975
Arg?Arg?Thr?Leu?Arg?Ser?Thr?Leu?Asp?Thr?Trp?Arg?His?Arg?Val?Thr
980?????????????????985?????????????????990
Trp?Thr?Ala?Leu?Thr?Gly?Ala?Asp?Asp?Ala?Val?Pro?Ala?Gly?Arg?Trp
995?????????????????1000????????????????1005
Pro?Ala?Leu?Val?Pro?Ala?Gly?His?Ala?Asp?Asp?Pro?Trp?Val?His
1010????????????????1015????????????????1020
Ala?Val?Leu?Gly?Ala?Leu?Thr?Gly?Arg?Gly?Leu?Arg?Val?Glu?Arg
1025????????????????1030????????????????1035
His?Asp?Leu?Thr?Gly?Asp?Glu?Asp?Thr?Ala?Ala?Leu?Thr?Ala?Leu
1040????????????????1045????????????????1050
Leu?Thr?Gly?Thr?Gly?Asp?Thr?Glu?Pro?Asp?Gly?Ala?Glu?Gly?Ile
1055????????????????1060????????????????1065
Ala?Gly?Val?Leu?Ser?Leu?Leu?Ala?Leu?Asp?Glu?Arg?Pro?His?Pro
1070????????????????1075????????????????1080
Asp?His?Pro?Ala?Val?Pro?Arg?Gly?Leu?Ala?Thr?Ala?Lys?Glu?Leu
1085????????????????1090????????????????1095
Leu?His?Ala?Leu?Ser?Gly?Thr?Glu?Ala?Ser?Val?Trp?Ala?Leu?Thr
1100????????????????1105????????????????1110
Arg?Gly?Ala?Val?Ala?Val?Asp?Ser?Arg?Asp?Arg?Leu?Thr?Ser?Pro
1115????????????????1120????????????????1125
Val?Gln?Ala?Glu?Thr?Trp?Gly?Phe?Gly?Arg?Ala?Val?Ala?Leu?Glu
1130????????????????1135????????????????1140
Leu?Pro?Asp?Ala?Trp?Gly?Gly?Leu?Ala?Asp?Leu?Pro?Ala?Asp?Pro
1145????????????????1150????????????????1155
Asp?Ala?Arg?Ser?Leu?Ala?Arg?Leu?Ala?Thr?Leu?Leu?Gly?Gly?Pro
1160????????????????1165????????????????1170
Glu?Asp?Gln?Ile?Ala?Val?Arg?Ser?Ser?Gly?Ala?Tyr?Ala?Arg?Arg
1175????????????????1180????????????????1185
Leu?Ala?Arg?Met?Pro?Leu?Pro?Glu?Pro?Ala?Arg?Val?Thr?Asp?Val
1190????????????????1195????????????????1200
Asp?Ala?Glu?Leu?Ala?Val?Arg?Ala?Ala?Asp?Asp?Asp?Gly?Ile?Gly
1205????????????????1210????????????????1215
Gly?Trp?Gly?Asp?His?Asp?Thr?Val?Leu?Ile?Thr?Gly?Gly?Thr?Gly
1220????????????????1225????????????????1230
Ala?Leu?Gly?Ala?His?Val?Ala?Arg?Ser?Leu?Ala?Ala?Ser?Gly?Ala
1235????????????????1240????????????????1245
Arg?His?Leu?Val?Leu?Thr?Ser?Arg?Arg?Gly?Pro?Gly?Ser?Pro?Gly
1250????????????????1255????????????????1260
Ala?Val?Gly?Leu?Val?Ala?Glu?Leu?Glu?Glu?Leu?Gly?Ala?Arg?Val
1265????????????????1270????????????????1275
Thr?Val?Ala?Asp?Cys?Asp?Val?Ala?Asp?Arg?Asp?Gln?Leu?Ala?Arg
1280????????????????1285????????????????1290
Leu?Leu?Asp?Ser?Leu?Pro?Ala?Gly?Leu?Pro?Leu?Thr?Gly?Val?Val
1295????????????????1300????????????????1305
His?Ala?Ala?Gly?Val?Leu?Asp?Asp?Gly?Val?Leu?Asp?Ala?Leu?Thr
1310????????????????1315????????????????1320
Leu?Asp?Arg?Phe?Glu?Ala?Val?Leu?Arg?Pro?Lys?Thr?Leu?Gly?Thr
1325????????????????1330????????????????1335
Ala?His?Leu?His?Glu?Leu?Thr?Arg?Asp?His?Asp?Val?Thr?Leu?Phe
1340????????????????1345????????????????1350
Val?Leu?Phe?Ser?Ser?Ile?Val?Gly?Val?Leu?Gly?Asn?Ala?Gly?Gln
1355????????????????1360????????????????1365
Ala?Ash?Tyr?Ala?Ala?Ala?Asn?Ala?Tyr?Leu?Asp?Ala?Val?Ala?Glu
1370????????????????1375????????????????1380
Gln?Arg?Arg?Ala?Glu?Gly?Leu?Pro?Val?Thr?Ser?Val?Ala?Trp?Gly
1385????????????????1390????????????????1395
Pro?Trp?Ala?Asp?Ala?Gly?Met?Ala?Thr?Ala?Asp?Val?Leu?Ala?Asp
1400????????????????1405????????????????1410
Arg?Met?Ser?His?Asp?Gly?Leu?Ala?Pro?Met?Asp?Pro?Val?Thr?Ala
1415????????????????1420????????????????1425
Val?Ala?Ala?Leu?Arg?Ala?Ala?Val?Ala?Glu?Gly?Val?Pro?His?Ala
1430????????????????1435????????????????1440
Thr?Val?Leu?Asp?Val?Asp?Trp?Arg?Ala?Tyr?Gly?Thr?Ala?Met?Thr
1445????????????????1450????????????????1455
Ala?Ala?Arg?Pro?Ser?Pro?Leu?Val?Gly?Asp?Leu?Pro?Glu?Val?Arg
1460????????????????1465????????????????1470
Arg?Ala?Leu?Glu?Ala?Ala?Ala?Ala?Thr?Ala?Pro?Asp?Thr?His?Ala
1475????????????????1480????????????????1485
Leu?Arg?Asp?Arg?Leu?Arg?Gly?Leu?Ala?Pro?Ala?Glu?Gln?Asp?Arg
1490????????????????1495????????????????1500
Leu?Leu?Thr?Asp?Leu?Val?Arg?Ala?Glu?Val?Ala?Thr?Ala?Leu?Arg
1505????????????????1510????????????????1515
His?Ser?Ser?Pro?Glu?Ala?Val?Asp?Val?Asn?Arg?Ala?Phe?Lys?Asp
1520????????????????1525????????????????1530
Leu?Gly?Phe?Asp?Ser?Leu?Thr?Ala?Val?Glu?Val?Arg?Asn?Arg?Ile
1535????????????????1540????????????????1545
Thr?Ala?Ala?Thr?Asp?Val?Lys?Leu?Pro?Thr?Thr?Leu?Leu?Phe?Asp
1550????????????????1555????????????????1560
Tyr?Pro?Asn?Thr?Thr?Ala?Val?Val?Ala?His?Leu?Arg?Thr?Leu?Leu
1565????????????????1570????????????????1575
Leu?Gly?Asp?Glu?Arg?Pro?Val?Ala?Ala?Pro?Val?Val?Val?Ser?Ala
1580????????????????1585????????????????1590
Gly?Val?Thr?Asp?Glu?Pro?Met?Ala?Val?Val?Ala?Met?Ala?Cys?Arg
1595????????????????1600????????????????1605
Phe?Pro?Gly?Gly?Val?Thr?Thr?Pro?Glu?Glu?Leu?Trp?His?Leu?Met
1610????????????????1615????????????????1620
Ala?Ala?Glu?Val?Asp?Ala?Val?Ser?Thr?Pro?Pro?Glu?Asp?Arg?Gly
1625????????????????1630????????????????1635
Trp?Asp?Leu?Asp?Ala?Leu?Tyr?Asp?Pro?Asp?Pro?Glu?Arg?His?Gly
1640????????????????1645????????????????1650
Thr?Thr?Tyr?Ser?Arg?Glu?Gly?Gly?Phe?Ile?Gln?Asp?Val?Ala?Gly
1655????????????????1660????????????????1665
Phe?Asp?Pro?Val?Phe?Phe?Gly?Ile?Ser?Pro?Arg?Glu?Ala?Leu?Ala
1670????????????????1675????????????????1680
Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu?Thr?Ser?Trp?Glu?Thr
1685????????????????1690????????????????1695
Phe?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Gly?Thr?Leu?Arg?Asn?Ser?Ala
1700????????????????1705????????????????1710
Thr?Gly?Val?Phe?Val?Gly?Ser?Ile?Thr?Thr?Asp?Tyr?Gln?Val?Arg
1715????????????????1720????????????????1725
Leu?Gly?Gly?Ala?Ala?Ala?Gln?Glu?Gln?Leu?Ala?Gly?His?Leu?Met
1730????????????????1735????????????????1740
Thr?Gly?Asn?Ala?Ser?Ser?Ile?Ala?Ser?Gly?Arg?Leu?Ser?Tyr?Thr
1745????????????????1750????????????????1755
Tyr?Gly?Phe?Glu?Gly?Pro?Ala?Val?Thr?Met?Asp?Thr?Gly?Cys?Ser
1760????????????????1765????????????????1770
Ser?Ser?Met?Val?Ala?Leu?His?Leu?Ala?Leu?Gln?Ser?Leu?Arg?Thr
1775????????????????1780????????????????1785
Gly?Glu?Cys?Thr?Met?Ala?Leu?Ala?Gly?Gly?Val?Thr?Val?Met?Ser
1790????????????????1795????????????????1800
Thr?Pro?Glu?Pro?Tyr?Val?Glu?Phe?Ser?Arg?Gln?Arg?Gly?Leu?Ala
1805????????????????1810????????????????1815
Ala?Asp?Gly?Arg?Cys?Lys?Ala?Phe?Ala?Glu?Gly?Ala?Asp?Gly?Met
1820????????????????1825????????????????1830
Gly?Phe?Ala?Glu?Gly?Val?Gly?Leu?Val?Leu?Leu?Glu?Arg?Leu?Ser
1835????????????????1840????????????????1845
Asp?Ala?Arg?Arg?Asn?Gly?His?Pro?Val?Leu?Ala?Val?Val?Arg?Gly
1850????????????????1855????????????????1860
Ser?Ala?Leu?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro
1865????????????????1870????????????????1875
Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val?Ile?Arg?Gln?Ala?Leu?Ala?Asn
1880????????????????1885????????????????1890
Ala?Gly?Leu?Ala?Pro?Gly?Glu?Val?Asp?Val?Val?Glu?Ala?His?Gly
1895????????????????1900????????????????1905
Thr?Gly?Thr?Pro?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala?Ile?Leu
1910????????????????1915????????????????1920
Ala?Thr?Tyr?Gly?Gln?Asp?Arg?Asp?Pro?Ala?Arg?Pro?Leu?Leu?Leu
1925????????????????1930????????????????1935
Gly?Ser?Leu?Lys?Ser?Asn?Ile?Gly?His?Thr?Gln?Ala?Ala?Ala?Gly
1940????????????????1945????????????????1950
Val?Ala?Gly?Met?Met?Lys?Met?Ile?Leu?Ala?Met?Arg?Gln?Gly?Thr
1955????????????????1960????????????????1965
Leu?Pro?Lys?Ser?Leu?His?Ile?Thr?Arg?Pro?Thr?Ser?Val?Val?Asp
1970????????????????1975????????????????1980
Trp?Ser?Ser?Gly?Ala?Val?Arg?Leu?Val?Thr?Glu?Ser?Thr?Pro?Trp
1985????????????????1990????????????????1995
Pro?Glu?Thr?Gly?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ser?Phe?Gly
2000????????????????2005????????????????2010
Ile?Ser?Gly?Thr?Asn?Gly?His?Leu?Ile?Leu?Glu?Glu?Ala?Pro?Ala
2015????????????????2020????????????????2025
Pro?Glu?Pro?Ala?Glu?Asp?Glu?Pro?Ala?Asp?Pro?Phe?Thr?Glu?Pro
2030????????????????2035????????????????2040
Ser?Ala?Asp?Asp?Ser?Ala?Asp?Thr?Val?Arg?Ser?Trp?Met?Val?Ser
2045????????????????2050????????????????2055
Gly?Lys?Ser?Arg?Ala?Ala?Val?Gly?Glu?Gln?Ala?Ala?Arg?Leu?Ala
2060????????????????2065????????????????2070
Ala?Ser?Val?Arg?Thr?Ser?Asp?Ala?Ser?Val?Leu?Asp?Val?Ala?His
2075????????????????2080????????????????2085
Ala?Leu?Val?Ser?Ser?Arg?Val?Ala?Met?Asp?Arg?Arg?Ala?Val?Val
2090????????????????2095????????????????2100
Val?Gly?Arg?Asp?Gly?Glu?Glu?Leu?Leu?Ala?Gly?Leu?Asp?Ala?Leu
2105????????????????2110????????????????2115
Ala?Ala?Gly?Glu?Pro?Ser?Pro?Arg?Leu?Val?Glu?Gly?Ser?Val?Gly
2120????????????????2125????????????????2130
Asp?Gly?Ser?Gly?Lys?Val?Ala?Phe?Val?Phe?Pro?Gly?Gln?Gly?Ser
2135????????????????2140????????????????2145
Gln?Trp?Val?Gly?Met?Ala?Val?Glu?Leu?Leu?Gly?Ser?Ser?Pro?Val
2150????????????????2155????????????????2160
Phe?Ala?Gly?Arg?Val?Ala?Glu?Cys?Ala?Ala?Ala?Leu?Glu?Pro?Phe
2165????????????????2170????????????????2175
Thr?Glu?Trp?Ser?Leu?Leu?Asp?Val?Leu?Asn?Gly?Val?Glu?Gly?Ala
2180????????????????2185????????????????2190
Ala?Ser?Leu?Glu?Arg?Val?Asp?Val?Val?Gln?Pro?Val?Leu?Trp?Ala
2195????????????????2200????????????????2205
Val?Met?Val?Ser?Leu?Ala?Glu?Val?Trp?Arg?Ala?Gln?Gly?Val?Glu
2210????????????????2215????????????????2220
Pro?Gly?Ala?Val?Ile?Gly?His?Ser?Gln?Gly?Glu?Ile?Ala?Ala?Ala
2225????????????????2230????????????????2235
Val?Val?Ala?Gly?Gly?Leu?Ser?Leu?Glu?Asp?Gly?Ala?Arg?Val?Val
2240????????????????2245????????????????2250
Ala?Leu?Arg?Ser?Arg?Ala?Leu?Arg?Ala?Leu?Ser?Gly?Leu?Gly?Gly
2255????????????????2260????????????????2265
Met?Val?Ser?Val?Ala?Arg?Asn?Val?Asp?Glu?Val?Arg?Gly?Leu?Leu
2270????????????????2275????????????????2280
Ala?Gly?Trp?Glu?Gly?Arg?Ile?Ser?Val?Ala?Ala?Val?Asn?Gly?Pro
2285????????????????2290????????????????2295
Ser?Ser?Val?Val?Val?Ser?Gly?Asp?Ala?Glu?Ala?Leu?Asp?Glu?Phe
2300????????????????2305????????????????2310
Val?Ala?Ala?Cys?Asp?Ala?Ser?Gly?Val?Arg?Ala?Arg?Arg?Val?Ala
2315????????????????2320????????????????2325
Val?Asp?Tyr?Ala?Ser?His?Ser?Ala?His?Val?Glu?Arg?Ile?Glu?Glu
2330????????????????2335????????????????2340
Glu?Leu?Ala?Gly?Leu?Leu?Ala?Pro?Val?Ala?Pro?Arg?Ser?Cys?Asp
2345????????????????2350????????????????2355
Val?Pro?Phe?Tyr?Ser?Thr?Leu?Ser?Gly?Gly?Val?Ile?Asp?Thr?Ala
2360????????????????2365????????????????2370
Gly?Leu?Asp?Ala?Gly?Tyr?Trp?Tyr?Arg?Asn?Leu?Arg?Gly?Thr?Val
2375????????????????2380????????????????2385
Glu?Phe?Glu?Ala?Gly?Thr?Arg?Ala?Leu?Leu?Ala?Asp?Gly?Phe?Arg
2390????????????????2395????????????????2400
Val?Phe?Val?Glu?Val?Ser?Ala?His?Pro?Val?Val?Ala?Thr?Gly?Val
2405????????????????2410????????????????2415
Gln?Glu?Thr?Ile?Glu?Asp?Ala?Ser?Val?Gln?Ala?Gly?Val?Val?Gly
2420????????????????2425????????????????2430
Thr?Leu?Arg?Arg?Asp?Glu?Gly?Gly?Leu?Glu?Arg?Phe?Ala?Leu?Ser
2435????????????????2440????????????????2445
Leu?Gly?Glu?Ala?Trp?Ala?Leu?Gly?Ala?Glu?Val?Asp?Trp?Glu?Thr
2450????????????????2455????????????????2460
His?Tyr?Ala?Gly?Thr?Arg?Pro?Arg?His?Val?Asp?Leu?Pro?Thr?Tyr
2465????????????????2470????????????????2475
Ala?Phe?Gln?Arg?Gln?His?Tyr?Trp?Pro?Arg?Phe?Ala?Glu?Leu?Gly
2480????????????????2485????????????????2490
Gly?Asp?Val?Ser?Ser?Ala?Gly?Leu?Asp?Ser?Pro?Asp?His?Pro?Leu
2495????????????????2500????????????????2505
Leu?Gly?Ala?Ser?Val?Glu?Leu?Ala?Gly?Gly?Asp?Gly?Leu?Val?Ala
2510????????????????2515????????????????2520
Thr?Ala?Arg?Trp?Ser?Leu?Arg?Thr?His?Pro?Trp?Leu?Ala?Asp?His
2525????????????????2530????????????????2535
Ala?Val?Ser?Gly?Thr?Val?Ile?Val?Pro?Gly?Thr?Ala?Leu?Val?Glu
2540????????????????2545????????????????2550
Ser?Val?Ile?Arg?Ala?Gly?Asp?Val?Leu?Gly?Cys?Gly?Arg?Ile?Glu
2555????????????????2560????????????????2565
Glu?Leu?Ala?Leu?Gln?Ala?Pro?Val?Val?Leu?Gln?Glu?Arg?Gly?Glu
2570????????????????2575????????????????2580
Ala?Gln?Val?Gln?Ile?Gly?Val?Gly?Glu?Pro?Asp?Ala?Ser?Gly?Arg
2585????????????????2590????????????????2595
Arg?Pro?Val?Thr?Val?His?Thr?Arg?Thr?Thr?Gly?Pro?Asp?Gly?Ala
2600????????????????2605????????????????2610
Thr?Glu?Asp?Leu?Trp?Thr?Leu?Arg?Ala?Gln?Gly?Thr?Leu?Thr?Glu
2615????????????????2620????????????????2625
Pro?Gly?Ala?Pro?Ala?Val?Asp?Arg?Pro?Glu?Glu?Phe?Thr?Ser?Trp
2630????????????????2635????????????????2640
Pro?Pro?Pro?Gly?Ala?Thr?Ala?Val?Ala?Ala?Glu?Gly?Phe?Tyr?Glu
2645????????????????2650????????????????2655
Leu?Leu?Ala?Gly?Arg?Gly?Tyr?Glu?Phe?Gly?Pro?Val?Phe?Gln?Gly
2660????????????????2665????????????????2670
Val?Arg?Ala?Thr?Trp?Ser?Arg?Gly?Glu?Asp?Leu?Tyr?Ala?Glu?Val
2675????????????????2680????????????????2685
Val?Leu?Pro?Glu?Gln?Val?Arg?Gly?Asp?Ala?Gly?Arg?Phe?Gly?Ile
2690????????????????2695????????????????2700
His?Pro?Ala?Leu?Leu?Asp?Ala?Ala?Leu?His?Ala?Ala?His?Leu?Ala
2705????????????????2710????????????????2715
Pro?Gly?Ser?Ala?Gly?Arg?Thr?Val?Val?Pro?Phe?Thr?Trp?Ser?Gly
2720????????????????2725????????????????2730
Val?Cys?Leu?His?Ala?Ala?Gly?Ala?Thr?Ala?Leu?Arg?Val?Arg?Val
2735????????????????2740????????????????2745
Ser?Pro?Ala?Gly?Gln?Asp?Ala?Ile?Ser?Val?Gln?Leu?Thr?Asp?Pro
2750????????????????2755????????????????2760
Thr?Gly?Ala?Pro?Val?Ala?Thr?Ile?Asp?Ala?Leu?Ala?Val?Arg?Glu
2765????????????????2770????????????????2775
Ile?Ala?Pro?Asp?Thr?Leu?Asp?Pro?Ser?Ala?Arg?Ala?Ala?Arg?Asp
2780????????????????2785????????????????2790
Trp?Leu?Phe?Arg?Leu?Asp?Trp?Thr?Pro?Val?Thr?Pro?Pro?Ala?Ala
2795????????????????2800????????????????2805
Val?Pro?Ala?Ala?Thr?Gly?Trp?Ala?Val?Leu?Gly?Thr?Pro?Ala?Asp
2810????????????????2815????????????????2820
Pro?Val?Thr?Ala?Pro?Asp?Gly?Ser?Gly?Thr?Thr?Leu?Pro?Ala?Phe
2825????????????????2830????????????????2835
Ala?Thr?Pro?Gly?Ala?Leu?Ala?Glu?His?Thr?Glu?Ala?Asn?Gly?His
2840????????????????2845????????????????2850
Arg?Pro?Asp?Ala?Val?Leu?Leu?Phe?Ala?Gly?Ala?Ala?Ala?Ser?Gly
2855????????????????2860????????????????2865
Thr?Ala?Ala?Ala?Pro?Asp?Ala?Glu?Pro?Gly?Val?Pro?Asp?Ala?Val
2870????????????????2875????????????????2880
Leu?Asp?Asp?Val?Leu?Ala?Thr?Val?Gln?Ser?Trp?Leu?Ala?Asp?Glu
2885????????????????2890????????????????2895
Thr?Thr?Glu?Gly?Val?Pro?Leu?Val?Val?Val?Thr?Arg?Gly?Ala?Val
2900????????????????2905????????????????2910
Pro?Thr?Gly?Pro?Ala?Asp?Pro?Ala?His?Asp?Leu?Pro?Gly?Ala?Ala
2915????????????????2920????????????????2925
Val?Trp?Gly?Leu?Val?Arg?Ser?Ala?Gln?Ser?Gln?His?Pro?Gly?Arg
2930????????????????2935????????????????2940
Leu?Val?Leu?Val?Asp?Leu?Asp?Ile?His?Asp?Asp?Ser?Trp?Leu?Ala
2945????????????????2950????????????????2955
Leu?Pro?Ala?Ala?Leu?Ala?Ala?Gly?Glu?Pro?Gln?Leu?Ala?Leu?Arg
2960????????????????2965????????????????2970
Gln?Gly?Ala?Ala?Tyr?Ala?Pro?Arg?Leu?Val?Arg?Pro?Arg?Thr?Ser
2975????????????????2980????????????????2985
Asp?Ala?Leu?Thr?Val?Pro?Glu?Gly?Thr?Gly?Asn?Trp?Arg?Leu?Asp
2990????????????????2995????????????????3000
Ile?Pro?Glu?Lys?Gly?Ser?Val?Asp?Arg?Leu?Asp?Leu?Val?Ala?Ala
3005????????????????3010????????????????3015
Pro?Gly?Thr?Ala?Glu?Glu?Pro?Ala?Ala?Gly?Glu?Val?Val?Ile?Glu
3020????????????????3025????????????????3030
Val?Arg?Ala?Ala?Gly?Leu?Asn?Phe?Arg?Asp?Val?Leu?Asn?Thr?Leu
3035????????????????3040????????????????3045
Gly?Met?Tyr?Pro?Gly?Pro?Ala?Val?Leu?Leu?Gly?Ala?Glu?Ala?Ala
3050????????????????3055????????????????3060
Gly?Val?Val?Thr?Ala?Val?Gly?Glu?Gly?Val?Thr?Gly?Phe?Ala?Pro
3065????????????????3070????????????????3075
Gly?Asp?Arg?Val?Met?Gly?Leu?Val?Ser?Gly?Gly?Phe?Ala?Pro?Arg
3080????????????????3085????????????????3090
Ala?Val?Ala?Asp?Ala?Arg?Met?Leu?Ala?Pro?Val?Pro?Asp?Gly?Trp
3095????????????????3100????????????????3105
Thr?Trp?Ala?Gln?Ala?Ala?Ser?Val?Pro?Val?Ala?Phe?Leu?Thr?Ala
3110????????????????3115????????????????3120
Tyr?Tyr?Gly?Leu?Arg?Asp?Leu?Ala?His?Leu?Asp?Ala?Gly?Glu?Ser
3125????????????????3130????????????????3135
Val?Leu?Val?His?Ala?Ala?Ala?Gly?Gly?Val?Gly?Met?Ala?Ala?Ala
3140????????????????3145????????????????3150
Gln?Leu?Ala?Arg?His?Trp?Gly?Ala?Glu?Val?Tyr?Gly?Thr?Ala?Gly
3155????????????????3160????????????????3165
Asp?His?Lys?Arg?Thr?Leu?Leu?Arg?Ala?Asp?Gly?Trp?Asp?Asp?Ala
3170????????????????3175????????????????3180
His?Leu?Ala?Ser?Ser?Arg?Thr?Leu?Ala?Phe?Glu?Asp?Arg?Phe?Arg
3185????????????????3190????????????????3195
Thr?Thr?Ser?Gly?Gly?Arg?Gly?Val?Asp?Val?Val?Leu?Asn?Ser?Leu
3200????????????????3205????????????????3210
Ala?Gly?Asp?Tyr?Ile?Asp?Ala?Ser?Leu?Arg?Leu?Leu?Ala?Pro?Gly
3215????????????????3220????????????????3225
Gly?Arg?Leu?Val?Asp?Met?Gly?Lys?Thr?Asp?Val?Arg?Asp?Pro?Gly
3230????????????????3235????????????????3240
Gln?Val?Leu?Arg?Asp?His?Pro?Ala?Ala?Ala?Leu?Tyr?Gln?Ala?Tyr
3245????????????????3250????????????????3255
Glu?Leu?Arg?Glu?Ala?Gly?Glu?Asp?Arg?lle?Gln?Glu?Met?Phe?Arg
3260????????????????3265????????????????3270
Asp?Leu?Ser?Glu?Leu?Phe?Ala?Ser?Gly?Ala?Leu?Arg?Pro?Leu?Pro
3275????????????????3280????????????????3285
Thr?Val?Thr?Trp?Asp?Val?Arg?His?Ala?Arg?Glu?Ala?Phe?Arg?His
3290????????????????3295????????????????3300
Met?Ala?Gln?Ala?Lys?His?Tyr?Gly?Lys?Ile?Val?Leu?Thr?Leu?Pro
3305????????????????3310????????????????3315
Arg?Ala?Trp?Asp?Pro?Glu?Gly?Thr?Val?Leu?Val?Thr?Gly?Gly?Ala
3320????????????????3325????????????????3330
Gly?Val?Leu?Gly?Gly?Ile?Leu?Ala?Arg?His?Leu?Val?Thr?Arg?His
3335????????????????3340????????????????3345
Gly?Met?Arg?His?Leu?Val?Leu?Thr?Gly?Arg?Arg?Gly?Pro?Asp?Thr
3350????????????????3355????????????????3360
Pro?Gly?Ala?Gly?Glu?Leu?Ala?Ala?Glu?Leu?Arg?Glu?Leu?Gly?Ala
3365????????????????3370????????????????3375
Glu?Val?Thr?Leu?Ala?Ala?Cys?Asp?Ala?Ala?Asp?Ala?Asp?Ala?Leu
3380????????????????3385????????????????3390
Ala?Ala?Val?Leu?Ala?Ala?Val?Pro?Ala?Glu?His?Pro?Leu?Thr?Ala
3395????????????????3400????????????????3405
Val?Val?His?Ala?Ala?Gly?Val?Leu?Asp?Asp?Gly?Val?Leu?Glu?Ser
3410????????????????3415????????????????3420
Leu?Thr?Pro?Asp?Arg?Leu?Arg?Thr?Val?Leu?Ala?Pro?Lys?Ala?Asp
3425????????????????3430????????????????3435
Ala?Ala?Arg?His?Leu?His?Arg?Leu?Thr?Arg?Asp?Leu?Asp?Leu?Thr
3440????????????????3445????????????????3450
Asp?Leu?Val?Leu?Phe?Ser?Ala?Gly?Ala?Gly?Val?Phe?Gly?Asn?Ala
3455????????????????3460????????????????3465
Gly?Gln?Ala?Asn?Tyr?Ala?Ala?Ala?Asn?Thr?Tyr?Leu?Asp?Ala?Leu
3470????????????????3475????????????????3480
Ala?His?Arg?Arg?Arg?Ala?Asp?Gly?Leu?Pro?Thr?Thr?Ser?Leu?Ser
3485????????????????3490????????????????3495
Trp?Gly?Leu?Trp?Ala?Asp?Thr?Ser?Ala?Leu?Thr?Gly?Gln?Leu?Asp
3500????????????????3505????????????????3510
Asp?Thr?Asp?Leu?Ala?Arg?Val?Arg?Arg?Ser?Gly?Val?Leu?Pro?Leu
3515????????????????3520????????????????3525
Ser?Ala?Ala?Asp?Gly?Met?Val?Leu?Phe?Asp?Ala?Ala?Leu?Thr?Glu
3530????????????????3535????????????????3540
Gln?Arg?Pro?His?Leu?Val?Pro?Val?Arg?Leu?Glu?Thr?Gly?Gln?Leu
3545????????????????3550????????????????3555
Arg?Ala?Ser?Gly?Asp?Glu?Val?Pro?Pro?Leu?Leu?Arg?Ser?Leu?Tyr
3560????????????????3565????????????????3570
Arg?Gly?Pro?Val?Arg?Arg?Thr?Ala?Glu?Ala?Gly?Ala?Ala?Thr?Gly
3575????????????????3580????????????????3585
Thr?Asp?Gly?Leu?Arg?Ala?Arg?Leu?Ala?Gly?Arg?Ser?Ala?Glu?Asp
3590????????????????3595????????????????3600
Arg?Leu?Ser?Thr?Leu?Arg?Asp?Leu?Val?Gly?Ala?His?Ala?Ala?Ala
3605????????????????3610????????????????3615
Val?Leu?Gly?His?Asp?Asp?Thr?Glu?Pro?Phe?His?Ala?Gly?Arg?Ala
3620????????????????3625????????????????3630
Phe?Arg?Asp?Leu?Gly?Phe?Asp?Ser?Leu?Thr?Ala?Val?Glu?Leu?Arg
3635????????????????3640????????????????3645
Asn?Arg?Leu?Ser?Ala?Ala?Thr?Gly?Leu?Arg?Leu?Pro?Ala?Thr?Leu
3650????????????????3655????????????????3660
Val?Phe?Asp?His?Pro?Thr?Val?Ala?Ala?Leu?Ala?Ala?His?Leu?Asp
3665????????????????3670????????????????3675
Gly?Glu?Leu?Ser?Asp?Gly?Thr?Pro?Ala?Ala?Leu?Pro?Ala?Ala?Pro
3680????????????????3685????????????????3690
Ala?Pro?Ala?Pro?Ala?Ala?Pro?Gly?Asp?Asp?Asp?Pro?Phe?Ala?Ile
3695????????????????3700????????????????3705
Val?Gly?Met?Ala?Cys?Arg?Leu?Pro?Gly?Asp?Ile?His?Ser?Pro?Glu
3710????????????????3715????????????????3720
Asp?Leu?Trp?Arg?Leu?Leu?Ala?Asp?Gly?Ala?Asp?Ala?Val?Ala?Pro
3725????????????????3730????????????????3735
Phe?Pro?Asp?Asp?Arg?Gly?Trp?Asp?Leu?Ala?Arg?Leu?Tyr?Asp?Ser
3740????????????????3745????????????????3750
Val?Pro?Glu?Gly?Gln?Gly?Ser?Ser?Arg?Thr?Arg?Glu?Gly?Gly?Phe
3755????????????????3760????????????????3765
Leu?His?Asp?Ala?Ala?Asp?Phe?Asp?Ala?Asp?Phe?Phe?Gly?Ile?Ser
3770????????????????3775????????????????3780
Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu
3785????????????????3790????????????????3795
Glu?Thr?Ala?Trp?Glu?Thr?Phe?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Arg
3800????????????????3805????????????????3810
Ser?Val?Arg?Gly?Ser?Arg?Thr?Gly?Val?Phe?Ala?Gly?Leu?Ser?Ser
3815????????????????3820????????????????3825
Ser?Asp?Tyr?Leu?Lys?Arg?Val?Thr?His?Val?Pro?Asp?Glu?Ile?Ala
3830????????????????3835????????????????3840
Gly?Tyr?Val?Asn?Asn?Gly?Asn?Ala?Asn?Ser?Ile?Val?Ser?Gly?Arg
3845????????????????3850????????????????3855
Val?Ser?Tyr?Thr?Leu?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp
3860????????????????3865????????????????3870
Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His?Met?Ala?Leu?Gln
3875????????????????3880????????????????3885
Ala?Leu?Arg?Arg?Gly?Glu?Cys?Thr?Met?Ala?Leu?Ala?Gly?Gly?Val
3890????????????????3895????????????????3900
Thr?Val?Met?Ser?Ser?Pro?Glu?Ile?Ile?Val?Asp?Phe?Ser?Arg?Gln
3905????????????????3910????????????????3915
Arg?Gly?Leu?Ala?Ala?Asp?Gly?Arg?Cys?Lys?Pro?Phe?Ala?Glu?Ala
3920????????????????3925????????????????3930
Ala?Asp?Gly?Thr?Gly?Phe?Ser?Glu?Gly?Val?Gly?Leu?Ile?Leu?Val
3935????????????????3940????????????????3945
Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Gln?Val?Leu?Ala
3950????????????????3955????????????????3960
Val?Val?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly
3965????????????????3970????????????????3975
Leu?Ser?Ala?Pro?Asn?Gly?Pro?Ala?Gln?Gln?Arg?Val?Ile?Arg?Gln
3980????????????????3985????????????????3990
Ala?Leu?Ala?Asp?Ala?Gly?Val?Gly?Ala?Ala?Glu?Val?Asp?Val?Val
3995????????????????4000????????????????4005
Glu?Ala?His?Gly?Thr?Gly?Thr?Arg?Leu?Gly?Asp?Pro?Ile?Glu?Ala
4010????????????????4015????????????????4020
Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Arg?Asp?Arg?Asp?Gly?Gly?His
4025????????????????4030????????????????4035
Pro?Leu?Phe?Leu?Gly?Ser?Val?Lys?Ser?Asn?Leu?Gly?His?Thr?Gln
4040????????????????4045????????????????4050
Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Met?Lys?Met?Val?Leu?Ala?Leu
4055????????????????4060????????????????4065
Arg?His?Arg?Leu?Leu?Pro?Glu?Ser?Leu?His?Ile?Asp?Ala?Pro?Thr
4070????????????????4075????????????????4080
Pro?His?Val?Asp?Trp?Ala?Asp?Ser?Gly?Val?Arg?Leu?Leu?Thr?Glu
4085????????????????4090????????????????4095
Ala?Thr?Ala?Trp?Pro?Glu?Ala?Gly?Ala?Ser?Arg?Pro?Arg?Arg?Ala
4100????????????????4105????????????????4110
Ala?Val?Ser?Ser?Phe?Gly?Ile?Ser?Gly?His?Gln?Arg?Pro?Arg?His
4115????????????????4120????????????????4125
Pro?Gly?Gly?Gly?Pro?Pro?Pro?Pro?Pro?Ala?Arg?Thr?Ala?Ala?Ser
4130????????????????4135????????????????4140
Arg?Ser?Pro?Pro?Ala?Pro?Asp?Ala?Ala?Glu?Thr?Arg?Pro?Ala?Pro
4145????????????????4150????????????????4155
Leu?Pro?Trp?Val?Leu?Ser?Ala?Arg?Ser?Glu?Ala?Ala?Leu?Arg?Gly
4160????????????????4165????????????????4170
Gln?Ala?Lys?Ala?Leu?Leu?Thr?His?Leu?Asp?Ala?His?Pro?Gly?Thr
4175????????????????4180????????????????4185
Asp?Pro?Ala?Asp?Ile?Ala?His?Thr?Leu?Val?Thr?Arg?Arg?Ala?Gln
4190????????????????4195????????????????4200
Leu?Glu?Lys?Arg?Ala?Val?Val?Val?Gly?Ser?Ala?Thr?Gly?Asp?Phe
4205????????????????4210????????????????4215
Arg?Ala?Gly?Leu?Ala?Ala?Leu?Ala?Glu?Gly?Ser?Pro?Ala?Ala?His
4220????????????????4225????????????????4230
Val?Val?Thr?Gly?Gly?Arg?Gly?Ala?Gly?Arg?Asp?Arg?Arg?Thr?Val
4235????????????????4240????????????????4245
Leu?Val?Phe?Pro?Gly?Gln?Gly?Ser?Gln?Trp?Ala?Gly?Met?Gly?Ala
4250????????????????4255????????????????4260
Glu?Leu?Leu?Asp?Ala?Ser?Pro?Ala?Phe?Ala?Asp?Arg?Val?Ala?Ala
4265????????????????4270????????????????4275
Cys?Glu?Glu?Ala?Leu?Ala?Pro?Tyr?Val?Asp?Trp?Ser?Leu?Thr?Ala
4280????????????????4285????????????????4290
Val?Leu?Arg?Gln?Glu?Glu?Gly?Ala?Pro?Ala?Leu?Asp?Arg?Val?Asp
4295????????????????4300????????????????4305
Val?Val?Gln?Pro?Val?Thr?Trp?Ala?Val?Met?Val?Ala?Leu?Ala?Glu
4310????????????????4315????????????????4320
Val?Trp?Arg?Ala?His?Gly?Leu?Arg?Pro?Ala?Ala?Val?Leu?Gly?His
4325????????????????4330????????????????4335
Ser?Gln?Gly?Glu?Ile?Ala?Ala?Ala?Ala?Val?Ala?Gly?Ala?Leu?Ser
4340????????????????4345????????????????4350
Leu?Ala?Asp?Ala?Ala?Arg?Ile?Val?Ala?Val?Arg?Ser?Arg?Ala?Ile
4355????????????????4360????????????????4365
Ala?Arg?Glu?Leu?Ser?Gly?His?Gly?Gly?Met?Val?Ala?Val?Thr?Ala
4370????????????????4375????????????????4380
Pro?His?Asp?Glu?Val?Thr?Ala?Leu?Leu?Ala?Asp?Leu?Pro?Gly?Val
4385????????????????4390????????????????4395
Cys?Val?Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val?Val?Val?Ser?Gly
4400????????????????4405????????????????4410
Asp?Thr?Gly?Gly?Leu?Asp?Thr?Leu?Leu?Ala?Ala?Cys?Glu?Glu?Gln
4415????????????????4420????????????????4425
Gly?Val?Arg?Ala?Arg?Arg?Val?Pro?Val?Asp?Tyr?Ala?Ser?His?Ser
4430????????????????4435????????????????4440
Ala?His?Val?Asp?Arg?Leu?Ala?Glu?Ser?Leu?Pro?Ala?Ala?Leu?Asp
4445????????????????4450????????????????4455
Gly?Ile?Glu?Pro?Arg?Asp?Gly?Asp?Ile?Pro?Phe?Phe?Ser?Thr?Val
4460????????????????4465????????????????4470
Thr?Ala?Asp?Trp?His?Pro?Gly?Thr?Gly?Leu?Gly?Ala?Ala?Tyr?Trp
4475????????????????4480????????????????4485
His?Arg?Asn?Leu?Arg?Gly?Thr?Val?Arg?Leu?Glu?Glu?Ser?Leu?Arg
4490????????????????4495????????????????4500
Ala?Leu?Val?Glu?Gln?Gly?His?Asp?Val?Phe?Val?Glu?Cys?Gly?Pro
4505????????????????4510????????????????4515
His?Pro?Val?Leu?Thr?Val?Gly?Ile?Glu?Asp?Thr?Val?Ala?Ala?Leu
4520????????????????4525????????????????4530
Gly?Ala?Asp?Ala?Val?Ala?Leu?Gly?Ser?Leu?Arg?Arg?Asp?Asp?Gly
4535????????????????4540????????????????4545
Gly?Pro?Ala?Arg?Val?Leu?Thr?Ala?Leu?Ala?Ala?Ala?His?Val?Glu
4550????????????????4555????????????????4560
Gly?Val?Pro?Val?Asp?Trp?Arg?Pro?Ala?Val?Ser?His?Gly?Thr?Ala
4565????????????????4570????????????????4575
Val?Asp?Leu?Pro?Thr?Tyr?Ala?Phe?Gln?Arg?Arg?Arg?Tyr?Trp?Leu
4580????????????????4585????????????????4590
Asp?Ala?Gly?Thr?Pro?Gln?Gly?Asp?Pro?Ala?Gly?Leu?Asp?Ser?Val
4595????????????????4600????????????????4605
Val?Arg?Leu?Ala?Asp?Gly?Gly?Ala?Val?Leu?Ser?Gly?Ser?Leu?Ser
4610????????????????4615????????????????4620
Leu?Thr?Thr?Gln?Pro?Trp?Leu?Asp?Ala?His?Arg?Thr?His?Gly?Ala
4625????????????????4630????????????????4635
Ala?Val?Val?Pro?Thr?Thr?Ala?Leu?Leu?Asp?Trp?Ala?Val?Arg?Ala
4640????????????????4645????????????????4650
Gly?Asp?Glu?Thr?Gly?Leu?Pro?Val?Val?Ala?Ala?Leu?Asp?Glu?His
4655????????????????4660????????????????4665
Ser?Pro?Leu?Val?Val?Pro?Glu?Glu?Gly?His?Val?Glu?Ile?Gln?Leu
4670????????????????4675????????????????4680
Thr?Val?Ser?Ala?Ala?Asp?Thr?Asp?Ser?Arg?Pro?Phe?Ser?Val?His
4685????????????????4690????????????????4695
Ser?Arg?Leu?His?Ala?Ala?Asp?Ala?Gly?Glu?Pro?Ala?Thr?Pro?Trp
4700????????????????4705????????????????4710
Thr?Arg?Asn?Ala?Thr?Gly?Asp?Leu?Thr?Asp?Arg?Pro?Thr?Thr?Thr
4715????????????????4720????????????????4725
Pro?Gln?Ala?Ser?Gly?Thr?Trp?Pro?Pro?Ala?Asp?Ala?Val?Ala?Ala
4730????????????????4735????????????????4740
Asp?Pro?Ala?Pro?Val?Arg?Ala?Leu?Ala?Glu?Asp?Arg?Gly?Leu?Asp
4745????????????????4750????????????????4755
Leu?Ala?Ala?Pro?Phe?Asp?Thr?Val?Arg?Ser?Leu?Trp?Arg?Ala?Gly
4760????????????????4765????????????????4770
Thr?Asp?Val?Leu?Ala?Glu?Val?Ala?Leu?Pro?Asp?Ala?Ala?His?Ala
4775????????????????4780????????????????4785
Asp?Ala?Ala?Arg?Phe?Arg?Leu?His?Pro?Ala?Leu?Leu?Gln?Thr?Pro
4790????????????????4795????????????????4800
Leu?Ala?Leu?Ala?Ala?Thr?Thr?Glu?Glu?Ala?Thr?Ala?Pro?Val?Leu
4805????????????????4810????????????????4815
Pro?Ala?Ala?Trp?Arg?Asp?Val?Thr?Val?His?Ala?Thr?Gly?Ala?Ser
4820????????????????4825????????????????4830
Arg?Leu?Arg?Val?Arg?Leu?Thr?Pro?Gly?Asp?Asp?Ala?Thr?Trp?Ser
4835????????????????4840????????????????4845
Val?Glu?Ala?Arg?Asp?Ala?Ala?Gly?Asp?Leu?Val?Leu?Thr?Gly?Thr
4850????????????????4855????????????????4860
Ala?Val?Thr?Arg?Ser?Ala?Gly?Pro?Asp?Arg?Leu?Pro?Ala?Thr?Ala
4865????????????????4870????????????????4875
Gly?Pro?Asp?Ala?Pro?His?Arg?Val?Ala?Trp?Leu?Pro?Trp?Thr?Asp
4880????????????????4885????????????????4890
Thr?Thr?Ser?Ser?Ala?Thr?Pro?Glu?Pro?His?Gly?Pro?Trp?Ala?Val
4895????????????????4900????????????????4905
Ile?Gly?Ala?Pro?Gly?Arg?Leu?Thr?Ala?Ala?Leu?Glu?Arg?Ser?Gly
4910????????????????4915????????????????4920
Ala?Thr?Val?Gln?Leu?His?Pro?Asp?Leu?Ala?Ala?Leu?Thr?Thr?Ala
4925????????????????4930????????????????4935
Leu?Asp?Asn?Asp?Glu?Ala?Ala?Pro?Pro?Ala?Leu?Val?Val?Ala?Phe
4940????????????????4945????????????????4950
His?Gly?His?Asp?Ser?Gly?Glu?Asp?Pro?Thr?Lys?Ala?Ala?His?Thr
4955????????????????4960????????????????4965
Ser?Ala?Ala?Arg?Ala?Leu?Thr?Leu?Ser?Thr?Ala?Trp?Leu?Arg?Glu
4970????????????????4975????????????????4980
Pro?Arg?Leu?Ala?Asp?Ala?Arg?Leu?Leu?Leu?Val?Thr?Glu?Gly?Ala
4985????????????????4990????????????????4995
Val?Ala?Thr?Gly?Pro?Asp?Asp?Thr?Val?Pro?Gly?Leu?Ala?Asp?Ala
5000????????????????5005????????????????5010
Thr?Ala?Trp?Gly?Leu?Leu?Arg?Ser?Ala?Gln?Thr?Glu?His?Pro?Gly
5015????????????????5020????????????????5025
Arg?Phe?Leu?Leu?Ala?Asp?Leu?Asp?Pro?Ala?Pro?Gly?Asp?Thr?Asp
5030????????????????5035????????????????5040
Glu?Asp?Ser?Ala?Ala?Asp?Ala?Leu?Ile?Ala?Ala?Ala?Ala?Ala?Ala
5045????????????????5050????????????????5055
Ala?Arg?Thr?Gly?Glu?His?Gln?Phe?Ala?Val?Arg?Ala?Gly?Thr?Val
5060????????????????5065????????????????5070
Thr?Val?Pro?Arg?Leu?Val?Pro?Ala?Gly?His?Pro?Glu?Gly?Ala?Pro
5075????????????????5080????????????????5085
Ala?Pro?Ala?Ala?Thr?Ala?Pro?Trp?Gly?Glu?Gly?Thr?Gly?Ala?Gly
5090????????????????5095????????????????5100
Thr?Val?Leu?Ile?Thr?Gly?Gly?Thr?Gly?Thr?Leu?Gly?Ala?Leu?Val
5105????????????????5110????????????????5115
Ala?Arg?His?Leu?Val?Thr?Arg?His?Gly?Val?Arg?His?Leu?Leu?Leu
5120????????????????5125????????????????5130
Thr?Ser?Arg?Arg?Gly?Pro?Gly?Ala?Pro?Gly?Ala?Ala?Ala?Leu?Arg
5135????????????????5140????????????????5145
Glu?Glu?Leu?Ala?Ala?Leu?Gly?Ala?Glu?Ala?Glu?Ile?Val?Ala?Cys
5150????????????????5155????????????????5160
Asp?Val?Ala?Asp?Arg?Glu?Gln?Leu?Ala?Gly?Val?Leu?Asp?Ala?Val
5165????????????????5170????????????????5175
Pro?Ala?Glu?His?Pro?Leu?Thr?Ala?Val?Val?His?Thr?Ala?Gly?Val
5180????????????????5185????????????????5190
Leu?Asp?Asp?Gly?Thr?Leu?Asp?Gly?Leu?Thr?Ala?Asp?Arg?Val?Ala
5195????????????????5200????????????????5205
His?Val?Leu?Arg?Pro?Lys?Ala?Asp?Ala?Ala?Trp?His?Leu?His?Glu
5210????????????????5215????????????????5220
Leu?Thr?Arg?Asp?Thr?Lys?Leu?Thr?Ala?Phe?Val?Met?Phe?Ser?Ser
5225????????????????5230????????????????5235
Tyr?Ala?Gly?Val?Ala?Gly?Gly?Pro?Gly?Gln?Ala?Asn?Tyr?Ala?Ala
5240????????????????5245????????????????5250
Ala?Asn?Ala?Phe?Leu?Asp?Ala?Leu?Ala?Gln?His?Arg?Arg?Ala?Ser
5255????????????????5260????????????????5265
Gly?Leu?Pro?Ala?His?Ser?Leu?Ala?Trp?Gly?Leu?Trp?Glu?Asp?Arg
5270????????????????5275????????????????5280
Ser?Asp?Leu?Thr?Gly?Ala?Leu?Asp?Thr?Thr?Gly?Leu?Ala?Arg?Leu
5285????????????????5290????????????????5295
Glu?Arg?Ser?Gly?Ile?Arg?Pro?Leu?Thr?Ala?Gly?Gln?Gly?Leu?Ala
5300????????????????5305????????????????5310
Leu?Leu?Asp?Ala?Ser?Thr?Ala?Leu?Asp?Thr?Ala?His?Leu?Val?Pro
5315????????????????5320????????????????5325
Val?Arg?Leu?Asp?Thr?Arg?Thr?Leu?Arg?Ala?Asp?Glu?Val?Pro?Pro
5330????????????????5335????????????????5340
Leu?Leu?Arg?Ala?Leu?Ala?Arg?Pro?Ala?Val?Arg?Arg?Ala?Ala?Asp
5345????????????????5350????????????????5355
Ser?Gly?Pro?Gly?Ala?Ala?Thr?Gly?Ala?Pro?Ala?Asp?Leu?Arg?Glu
5360????????????????5365????????????????5370
Arg?Leu?Ala?Gly?Leu?Ser?Gly?Pro?Gln?Gln?Arg?Ala?Leu?Leu?His
5375????????????????5380????????????????5385
Arg?Thr?Val?Leu?Gly?His?Leu?Ala?Ala?Val?Leu?Gly?His?Ala?Ser
5390????????????????5395????????????????5400
Ala?Ala?Ser?Leu?Asp?Ala?Asp?Arg?Gly?Phe?Leu?Asp?Leu?Gly?Met
5405????????????????5410????????????????5415
Ser?Ser?Leu?Thr?Ala?Val?Glu?Leu?Arg?Asn?Arg?Leu?Asn?Ala?Asp
5420????????????????5425????????????????5430
Thr?Gly?Leu?Ser?Leu?Pro?Thr?Thr?Leu?Ile?Phe?Asp?His?Pro?Asp
5435????????????????5440????????????????5445
Pro?Ala?Ala?Leu?Val?Arg?His?Leu?Gln?Thr?Glu?Leu?Gly?Thr?Gly
5450????????????????5455????????????????5460
Ala?Gly?Glu?Pro?Asp?Gln?Ala?Val?Phe?Ala?Glu?Leu?Ala?Ala?Leu
5465????????????????5470????????????????5475
Glu?Ala?Ala?Val?Gly?Gly?Ala?Ala?Leu?Asp?Asp?Gln?Asp?Arg?Ala
5480????????????????5485????????????????5490
Arg?Leu?Ala?Gln?Arg?Leu?Lys?Ala?Leu?Gly?Trp?Lys?Leu?Asp?Ala
5495????????????????5500????????????????5505
Thr?Ser?Gln?Asp?Ala?Asp?Glu?Pro?Asp?Asp?Asp?Ser?Asp?Leu?Asp
5510????????????????5515????????????????5520
Thr?Thr?Thr?Asp?Asp?Glu?Met?Phe?Asp?Leu?Ile?Asp?Asn?Glu?Leu
5525????????????????5530????????????????5535
Gly?Leu?Ala
5540
<210>5
<211>2049
<212>PRT
＜213〉streptomycete FR-008
<400>5
Met?Pro?Asp?Asp?Lys?Lys?Leu?Val?Asp?Tyr?Leu?Lys?Trp?Val?Thr?Ala
1???????????????5???????????????????10??????????????????15
Asp?Leu?His?Lys?Thr?Arg?Arg?Arg?Leu?Glu?Glu?Ala?Glu?Ala?His?Arg
20??????????????????25??????????????????30
Arg?Glu?Pro?Ile?Ala?Val?Val?Gly?Met?Ala?Cys?Arg?Leu?Pro?Gly?Gly
35??????????????????40??????????????????45
Val?Ala?Thr?Pro?Glu?Glu?Tyr?Trp?Arg?Leu?Leu?Glu?Glu?Gly?Arg?Asp
50??????????????????55??????????????????60
Gly?Ile?Ala?Pro?Phe?Pro?Ala?Asp?Arg?Gly?Trp?Asp?Leu?Asp?Ala?Leu
65??????????????????70??????????????????75??????????????????80
Asn?Gly?Glu?Gly?Ala?Gly?Ser?Ser?Ala?Ala?Gly?Glu?Gly?Gly?Phe?Val
85??????????????????90??????????????????95
Asp?Ala?Ala?Ala?Phe?Asp?Ala?Gly?Phe?Phe?Gly?Ile?Ser?Pro?Arg?Glu
100?????????????????105?????????????????110
Ala?Val?Ala?Met?Asp?Pro?Gln?Gln?Arg?Ile?Leu?Leu?Glu?Thr?Thr?Trp
115?????????????????120?????????????????125
Glu?Ala?Val?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Val?Ser?Leu?Arg?Gly?Ser
130?????????????????135?????????????????140
Arg?Thr?Gly?Val?Tyr?Val?Gly?Thr?Ala?Gly?Val?Asp?Tyr?Val?Gly?Val
145?????????????????150?????????????????155?????????????????160
Val?Met?Asn?Ser?Arg?Glu?Asp?Ala?Glu?Gly?His?Ala?Thr?Thr?Gly?Leu
165?????????????????170?????????????????175
Thr?Ala?Ser?Val?Val?Ser?Gly?Arg?Leu?Ser?Tyr?Ala?Phe?Asp?Leu?Ala
180?????????????????185?????????????????190
Gly?Pro?Ala?Val?Thr?Val?Asp?Thr?Ala?Cys?Ser?Ala?Ser?Leu?Val?Ala
195?????????????????200?????????????????205
Ile?His?Leu?Ala?Ala?Gln?Ala?Leu?Arg?Asn?Gly?Glu?Cys?Gly?Leu?Ala
210?????????????????215?????????????????220
Leu?Ala?Gly?Gly?Val?Thr?Val?Met?Ser?Thr?Pro?Met?Gly?Phe?Ser?Gly
225?????????????????230?????????????????235?????????????????240
Phe?Thr?Arg?Gln?Gly?Gly?Ile?Ser?Thr?Ser?Gly?Arg?Cys?Lys?Ala?Phe
245?????????????????250?????????????????255
Ala?Asp?Ser?Ala?Asp?Gly?Thr?Gly?Trp?Ala?Glu?Gly?Ala?Gly?Val?Leu
260?????????????????265?????????????????270
Val?Leu?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Gln?Val?Leu
275?????????????????280?????????????????285
Ala?Val?Val?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly
290?????????????????295?????????????????300
Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val?Ile?Arg?Gln?Ala
305?????????????????310?????????????????315?????????????????320
Leu?Ala?Gly?Ala?Gly?Leu?Ser?Ala?Ala?Asp?Val?Asp?Ala?Val?Glu?Ala
325?????????????????330?????????????????335
His?Gly?Thr?Gly?Thr?Pro?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala?Leu
340?????????????????345?????????????????350
Leu?Ala?Thr?Tyr?Gly?Gln?Asp?Arg?Pro?Glu?Asp?Arg?Pro?Leu?Leu?Leu
355?????????????????360?????????????????365
Gly?Ser?Val?Lys?Ser?Asn?Ile?Gly?His?Ser?Gln?Ala?Ala?Ala?Gly?Val
370?????????????????375?????????????????380
Ala?Gly?Val?Ile?Lys?Thr?Val?Leu?Ala?Ile?Gln?His?Gly?Val?Leu?Pro
385?????????????????390?????????????????395?????????????????400
Arg?Ser?Leu?His?Ile?Asp?Glu?Ala?Ser?Ser?His?Val?Asp?Trp?Gly?Ala
405?????????????????410?????????????????415
Gly?Asn?Val?Arg?Leu?Leu?Thr?Glu?Asn?Thr?Ala?Trp?Pro?Glu?Thr?Gly
420?????????????????425?????????????????430
Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr?Asn
435?????????????????440?????????????????445
Ala?His?Val?Val?Ile?Glu?Gln?Ala?Pro?Glu?Pro?Glu?Glu?Pro?Ala?Thr
450?????????????????455?????????????????460
Pro?Glu?Asp?Gly?Thr?Pro?Thr?Ala?Arg?Pro?Thr?Leu?Val?Pro?Trp?Pro
465?????????????????470?????????????????475?????????????????480
Val?Ser?Ala?Lys?Thr?Arg?Glu?Ala?Leu?Asp?Ala?Gln?Leu?Ala?Arg?Val
485?????????????????490?????????????????495
Thr?Ser?Val?Thr?Gly?Ala?Ala?Pro?Leu?Asp?Ile?Gly?His?Ser?Leu?Ala
500?????????????????505?????????????????510
Thr?Gly?Arg?Ser?Thr?Phe?Glu?His?Arg?Ala?Val?Leu?Leu?Ala?Gly?Pro
515?????????????????520?????????????????525
Glu?Gly?Glu?Pro?Ala?Glu?Ala?Ala?Arg?Gly?Arg?Ala?Thr?Glu?Arg?Thr
530?????????????????535?????????????????540
Leu?Ala?Leu?Leu?Phe?Ser?Gly?Gln?Gly?Ser?Gln?Arg?Ala?Gly?Met?Gly
545?????????????????550?????????????????555?????????????????560
Arg?Glu?Leu?Tyr?Glu?Arg?Phe?Pro?Val?Phe?Ala?Glu?Ala?Leu?Asp?Ala
565?????????????????570?????????????????575
Val?Val?Ala?Arg?Leu?Asp?Thr?Gly?Leu?Glu?Arg?Ser?Leu?Arg?Glu?Val
580?????????????????585?????????????????590
Leu?Phe?Val?Glu?Glu?Gly?Ser?Glu?Ala?Ala?Ala?Leu?Leu?Asp?Val?Thr
595?????????????????600?????????????????605
Gly?Tyr?Thr?Gln?Pro?Ala?Leu?Phe?Ala?Val?Glu?Val?Ala?Leu?Phe?Arg
610?????????????????615?????????????????620
Leu?Val?Glu?Ser?Trp?Gly?Val?Ser?Pro?Glu?Phe?Val?Ala?Gly?His?Ser
625?????????????????630?????????????????635?????????????????640
Val?Gly?Glu?Ile?Ala?Ala?Ala?His?Val?Ala?Gly?Val?Phe?Ser?Leu?Asp
645?????????????????650?????????????????655
Asp?Ala?Cys?Arg?Leu?Val?Ala?Ala?Arg?Ala?Arg?Leu?Met?Gln?Glu?Leu
660?????????????????665?????????????????670
Pro?Thr?Gly?Gly?Ala?Met?Val?Ala?Val?Arg?Ala?Thr?Glu?Ala?Glu?Val
675?????????????????680?????????????????685
Thr?Pro?Arg?Leu?Thr?Glu?Gly?Leu?Ser?Leu?Ala?Ala?Val?Asn?Gly?Pro
690?????????????????695?????????????????700
Asp?Ser?Val?Val?Val?Ser?Gly?Pro?Glu?Gly?Glu?Val?Thr?Ala?Leu?Ala
705?????????????????710?????????????????715?????????????????720
Ala?Glu?Phe?Glu?Thr?Glu?Gly?Arg?Lys?Ile?Gln?Arg?Leu?Ser?Val?Ser
725?????????????????730?????????????????735
His?Ala?Phe?His?Ser?Ala?Leu?Met?Glu?Pro?Met?Leu?Asp?Ala?Phe?Arg
740?????????????????745?????????????????750
Glu?Val?Ala?Arg?Ser?Leu?Glu?Tyr?Ala?Glu?Pro?Arg?Val?Pro?Val?Val
755?????????????????760?????????????????765
Ser?Asn?Val?Thr?Gly?Ala?Leu?Ala?Ala?Pro?Gly?Gln?Leu?Thr?Asp?Pro
770?????????????????775?????????????????780
Glu?Tyr?Trp?Val?Arg?His?Val?Arg?Glu?Thr?Val?Arg?Phe?Ala?Asp?Gly
785?????????????????790?????????????????795?????????????????800
Val?Arg?Thr?Leu?Ala?Glu?Ala?Gly?Ala?Asp?Ala?Phe?Leu?Glu?Ile?Gly
805?????????????????810?????????????????815
Pro?Gly?Gly?Val?Leu?Thr?Ala?Leu?Ala?Arg?Gln?Ser?Leu?Asp?Thr?Leu
820?????????????????825?????????????????830
Asp?Gly?Gly?Thr?Gly?Ala?Val?Ala?Ala?Pro?Ala?Leu?Arg?Ser?Arg?Arg
835?????????????????840?????????????????845
Pro?Glu?Gln?Glu?Ala?Leu?Leu?Thr?Gly?Leu?Ala?Gln?Leu?His?Val?Ala
850?????????????????855?????????????????860
Gly?Val?Arg?Val?Asp?Trp?Ala?Ala?Trp?Phe?Thr?Gly?Thr?Gly?Ala?Arg
865?????????????????870?????????????????875?????????????????880
Arg?Thr?Asp?Leu?Pro?Thr?Tyr?Ala?Trp?Gln?His?Arg?Arg?Tyr?Trp?Pro
885?????????????????890?????????????????895
Arg?Pro?Leu?Ala?His?Ala?Ala?Asp?Ile?Pro?Gly?Ala?Gly?Leu?Thr?Pro
900?????????????????905?????????????????910
Ala?Glu?His?Pro?Leu?Leu?Gly?Ala?Ala?Val?Ser?Leu?Ala?Gly?Ser?Glu
915?????????????????920?????????????????925
Gly?Val?Leu?Leu?Thr?Gly?Arg?Val?Gly?Leu?Arg?Thr?His?Pro?Trp?Leu
930?????????????????935?????????????????940
Ala?Asp?His?Val?Met?Gly?Gly?Leu?Val?Leu?Phe?Pro?Ala?Thr?Ala?Phe
945?????????????????950?????????????????955?????????????????960
Leu?Glu?Leu?Ala?Val?Arg?Ala?Gly?Asp?Gln?Ala?Gly?Cys?Gly?Arg?Val
965?????????????????970?????????????????975
Gln?Glu?Leu?Thr?Leu?Thr?Thr?Pro?Leu?Ala?Leu?Asp?Pro?Arg?Gly?Ala
980?????????????????985?????????????????990
Ala?Ser?Val?Gln?Val?Gly?Val?Gly?Pro?Pro?Asp?Ala?Ala?Gly?Cys?Arg
995?????????????????1000????????????????1005
Pro?Leu?Ala?Ile?His?Ser?Arg?Pro?Glu?Asp?Ala?Ala?Asp?Asp?Glu
1010????????????????1015????????????????1020
Pro?Trp?Thr?Gln?His?Ala?Thr?Gly?Val?Leu?Val?Ala?Gly?Ala?Arg
1025????????????????1030????????????????1035
Gln?Val?Ala?Phe?Gly?Gln?Ser?Ala?Trp?Pro?Pro?Ala?Asp?Ala?Thr
1040????????????????1045????????????????1050
Pro?Val?Asp?Leu?Asp?Gly?Phe?Tyr?Glu?Arg?Thr?Glu?Tyr?Gly?Pro
1055????????????????1060????????????????1065
Leu?Phe?Gln?Gly?Leu?Arg?Ala?Val?Trp?Thr?Arg?Gly?Asp?Glu?Val
1070????????????????1075????????????????1080
Leu?Ala?Glu?Leu?Glu?Leu?Pro?Ala?Arg?Ala?Asp?Asp?Ala?Ala?Leu
1085????????????????1090????????????????1095
Phe?Gly?Leu?His?Pro?Ala?Leu?Leu?Thr?Ala?Ala?Leu?His?Ala?Val
1100????????????????1105????????????????1110
Glu?Tyr?Val?Glu?Leu?Lys?Asp?Ala?Asp?Gln?Gly?Leu?Leu?Pro?Phe
1115????????????????1120????????????????1125
Ser?Trp?Ser?Gly?Val?Thr?Leu?His?Ala?Ser?Gly?Ala?Ala?Arg?Leu
1130????????????????1135????????????????1140
Arg?Val?Arg?Ile?Thr?Lys?Ala?Gly?Glu?Asp?Thr?Val?Ser?Ile?Ala
1145????????????????1150????????????????1155
Ala?Val?Asp?Thr?Ala?Gly?Arg?Pro?Val?Leu?Ser?Val?Glu?Ser?Leu
1160????????????????1165????????????????1170
Ala?Leu?Arg?Pro?Ser?Gly?Ala?Ala?Arg?Leu?Leu?Lys?Pro?Gly?Thr
1175????????????????1180????????????????1185
Asp?Arg?Ser?Thr?Leu?Leu?Gly?Leu?Asp?Trp?Val?Pro?Ala?Glu?Pro
1190????????????????1195????????????????1200
Thr?Gly?Pro?Ala?Ala?Gly?Gly?Pro?Arg?Val?Ala?Leu?Gly?Thr?Asp
1205????????????????1210????????????????1215
Pro?Phe?Gly?Thr?Gly?Thr?Val?Leu?Ala?Gly?Leu?Asp?Glu?Val?Thr
1220????????????????1225????????????????1230
Glu?Thr?Gly?Thr?Gln?Val?Leu?Val?Pro?Val?Pro?Asp?Gly?Gly?Glu
1235????????????????1240????????????????1245
Asp?Pro?Val?Thr?Ala?Thr?His?Glu?Ala?Thr?Arg?Ala?Thr?Leu?Ala
1250????????????????1255????????????????1260
Leu?Leu?Gln?Glu?Trp?Leu?Asp?Gly?Pro?Arg?Pro?Ala?Gly?Ala?Arg
1265????????????????1270????????????????1275
Leu?Val?Phe?Val?Ala?Arg?Gly?Val?Val?Ala?Ala?Arg?Pro?Gly?Asp
1280????????????????1285????????????????1290
Pro?Ala?Ala?Asn?Leu?Ala?Gly?Ala?Ala?Val?Trp?Gly?Met?Val?Arg
1295????????????????1300????????????????1305
Thr?Ala?Gln?Ala?Glu?His?Pro?Ala?Asp?Phe?Thr?Leu?Val?Asp?Val
1310????????????????1315????????????????1320
Glu?Pro?Gly?Ala?Pro?Phe?Pro?Leu?Glu?Ala?Val?Leu?Ala?Val?Asp
1325????????????????1330????????????????1335
Glu?Pro?Gln?Ala?Ala?Val?Arg?Asp?Gly?Gln?Val?Leu?Val?Gly?Arg
1340????????????????1345????????????????1350
Leu?Thr?Gln?Leu?Pro?Pro?Pro?Thr?Pro?Gln?Asp?Gly?Pro?Glu?Asn
1355????????????????1360????????????????1365
Thr?Asp?Pro?Phe?Gly?Val?Thr?Arg?Asp?Gly?Thr?Val?Leu?Val?Thr
1370????????????????1375????????????????1380
Gly?Gly?Thr?Gly?Thr?Leu?Gly?Ala?Arg?Thr?Ala?Arg?His?Leu?Val
1385????????????????1390????????????????1395
Thr?Arg?His?Gly?Val?Thr?Arg?Leu?Leu?Leu?Ala?Gly?Arg?Arg?Gly
1400????????????????1405????????????????1410
Pro?Asp?Ala?Pro?Gly?Ala?Ala?Ala?Leu?Arg?Glu?Glu?Leu?Thr?Ala
1415????????????????1420????????????????1425
Leu?Gly?Ala?His?Val?Thr?Val?Ala?Ala?Cys?Asp?Val?Ser?Asp?Arg
1430????????????????1435????????????????1440
Asp?Ala?Leu?Ala?Ala?Leu?Leu?Gly?Gly?Ile?Pro?Ala?Glu?His?Pro
1445????????????????1450????????????????1455
Leu?Thr?Ala?Val?Val?His?Ala?Ala?Gly?Val?Leu?Asp?Asp?Ala?Val
1460????????????????1465????????????????1470
Val?Thr?Ser?Leu?Thr?Pro?Asp?Arg?Leu?Ala?Thr?Val?Leu?Arg?Ser
1475????????????????1480????????????????1485
Lys?Ala?Asp?Ala?Ala?Trp?His?Leu?His?Asp?Leu?Thr?Arg?Gly?Leu
1490????????????????1495????????????????1500
Gly?Leu?Asp?Ala?Phe?Val?Leu?Tyr?Ser?Ser?Ile?Ser?Gly?Val?Thr
1505????????????????1510????????????????1515
Ala?Arg?Ala?Gly?Gln?Ala?Asn?Tyr?Val?Ala?Ala?Asn?Leu?Phe?Leu
1520????????????????1525????????????????1530
Asp?Thr?Leu?Ala?Gln?His?Arg?Ala?Ala?Gln?Gly?Leu?Pro?Ala?Leu
1535????????????????1540????????????????1545
Ser?Val?Ala?Trp?Gly?Ala?Trp?Asp?Leu?Asp?Glu?Gly?Met?Ala?Gly
1550????????????????1555????????????????1560
Asp?Leu?Leu?Thr?Asp?Thr?Gly?Arg?Arg?Arg?Ile?Arg?Ser?Gly?Gly
1565????????????????1570????????????????1575
Ile?Asp?Thr?Leu?Pro?Gly?Asp?Arg?Ala?Leu?Asp?Leu?Leu?Asp?Thr
1580????????????????1585????????????????1590
Ala?Leu?Thr?Leu?Gly?Glu?Pro?Leu?Val?Val?Ala?Thr?Asn?Leu?Ala
1595????????????????1600????????????????1605
Ala?Pro?Pro?Ala?Thr?Ala?His?Leu?Asp?Glu?Val?Pro?Pro?Leu?Met
1610????????????????1615????????????????1620
Arg?Gly?Leu?Val?Arg?Pro?Pro?Arg?Arg?Thr?Ala?Ala?Ala?Thr?Thr
1625????????????????1630????????????????1635
Asp?Ala?Pro?Ala?Arg?Val?Leu?Asp?Ala?Ala?Ser?Phe?Arg?Glu?Asn
1640????????????????1645????????????????1650
Phe?Ala?Asn?Leu?Gly?Ala?Gly?Glu?Gln?Glu?Thr?Thr?Leu?Arg?Glu
1655????????????????1660????????????????1665
Thr?Val?Val?Ala?Cys?Ala?Ala?Ala?Leu?Leu?Gly?His?Thr?Asp?Thr
1670????????????????1675????????????????1680
Ser?Glu?Ile?Asp?Pro?Asp?Arg?Asp?Phe?Leu?Glu?Leu?Gly?Phe?Asp
1685????????????????1690????????????????1695
Ser?Leu?Ile?Gly?Ile?Glu?Leu?Arg?Arg?Lys?Leu?Ser?Glu?Ile?Thr
1700????????????????1705????????????????1710
Gly?Leu?Gln?Leu?Pro?Ala?Ser?Ile?Val?Tyr?Asp?Ser?Gly?Ser?Pro
1715????????????????1720????????????????1725
Asn?Gly?Leu?Thr?Ala?Trp?Leu?Arg?Thr?Glu?Leu?Gly?Ala?Gln?Gly
1730????????????????1735????????????????1740
Ser?Gly?Ala?Pro?Gln?Thr?Gly?Ala?Ala?Gly?Gly?Pro?Thr?Glu?Asn
1745????????????????1750????????????????1755
Asp?Ser?Met?Glu?Arg?Leu?Phe?Leu?Asp?Gly?Leu?Ala?Gln?Gly?Lys
1760????????????????1765????????????????1770
Val?Arg?Glu?Ala?Gln?Arg?Met?Leu?Ala?Thr?Val?Ala?Ala?Leu?Arg
1775????????????????1780????????????????1785
Pro?Ser?Phe?Glu?Val?Thr?Ala?Glu?Leu?Glu?Asp?Leu?Pro?Trp?Pro
1790????????????????1795????????????????1800
Val?Thr?Leu?Ala?Glu?Gly?Pro?Ala?Pro?Thr?Arg?Leu?Val?Cys?Val
1805????????????????1810????????????????1815
Ser?Ala?Pro?Thr?Ala?Asn?Gly?Gly?Val?His?Gln?Tyr?Ala?Thr?Leu
1820????????????????1825????????????????1830
Ser?Gly?His?Phe?Arg?Gly?Arg?Arg?Asp?Val?Thr?Ala?Leu?Pro?Leu
1835????????????????1840????????????????1845
Ile?Gly?Phe?Asn?Thr?Gly?Glu?Ala?Leu?Pro?Ala?His?Ala?Glu?Ala
1850????????????????1855????????????????1860
Ala?Ala?Arg?Ile?Ile?Ala?Asp?Cys?Thr?Leu?Gln?Ala?Ala?Asp?Gly
1865????????????????1870????????????????1875
Lys?Pro?Phe?Val?Leu?Val?Gly?His?Ser?Ser?Gly?Gly?Ser?Leu?Ala
1880????????????????1885????????????????1890
Tyr?Ala?Ala?Ala?Gly?Val?Leu?Glu?His?Thr?Trp?Gly?lle?Arg?Pro
1895????????????????1900????????????????1905
Glu?Ala?Val?Val?Leu?Leu?Asp?Thr?Leu?Ser?Ile?Gln?His?Lys?Ser
1910????????????????1915????????????????1920
Asp?Glu?Gly?Val?Asp?Tyr?Asn?Gly?Met?Met?Lys?Phe?Asn?Phe?Thr
1925????????????????1930????????????????1935
Ala?Val?Asp?Asp?Ser?Pro?Val?Arg?Leu?Thr?Asn?Ser?Arg?Leu?Ser
1940????????????????1945????????????????1950
Ala?Met?Gly?Arg?Trp?Met?Val?Leu?Leu?Asn?Ala?Leu?Asp?Val?His
1955????????????????1960????????????????1965
Pro?Thr?Thr?Val?Pro?Val?Leu?Glu?Ile?Lys?Cys?Thr?Arg?Ala?Leu
1970????????????????1975????????????????1980
Ile?Glu?Gly?Val?Pro?Ala?Pro?Asp?Pro?Glu?Arg?Leu?His?Leu?Pro
1985????????????????1990????????????????1995
Val?Val?Pro?Asp?Ala?Glu?Val?Arg?Pro?Leu?Asp?Ser?Asp?His?Leu
2000????????????????2005????????????????2010
Ser?Leu?Ile?Arg?Glu?Asp?Ser?Gly?Pro?Ala?Ala?Asp?Leu?Met?Asp
2015????????????????2020????????????????2025
Ala?Trp?Leu?Thr?Ala?Leu?Glu?Thr?Thr?Ala?Thr?Thr?Asp?Ala?Pro
2030????????????????2035????????????????2040
Glu?Thr?Ala?Pro?Ala?Gly
2045
<210>6
<211>7771
<212>PRT
＜213〉streptomycete FR-008
<400>6
Met?Thr?Thr?Pro?Ser?Glu?Lys?Val?Val?Glu?Ala?Leu?Arg?Ala?Ser?Leu
1???????????????5???????????????????10??????????????????15
Lys?Glu?Thr?Glu?Arg?Leu?Arg?Arg?Gln?Asn?Arg?Asp?Leu?Ala?Ala?Ala
20??????????????????25??????????????????30
Ala?Ser?Glu?Pro?Val?Ala?Val?Val?Ala?Met?Ser?Cys?Arg?Tyr?Pro?Gly
35??????????????????40??????????????????45
Gly?Val?Thr?Ser?Pro?Glu?Asp?Leu?Trp?His?Leu?Val?Ala?Ser?Gly?Thr
50??????????????????55??????????????????60
Asp?Ala?Val?Gly?Gly?Phe?Pro?Thr?Asp?Arg?Gly?Trp?Asp?Leu?Asp?Ala
65??????????????????70??????????????????75??????????????????80
Leu?Arg?Asp?Ala?Gly?Val?Asp?Ala?Arg?Gly?His?Ser?Val?Ser?Gln?Arg
85??????????????????90??????????????????95
Gly?Gly?Phe?Leu?Asp?Gly?Val?Ala?Asp?Phe?Asp?Ala?Ala?Phe?Phe?Gly
100?????????????????105?????????????????110
Val?Ser?Pro?Arg?Glu?Ala?Val?Ser?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu
115?????????????????120?????????????????125
Leu?Glu?Thr?Ser?Trp?Glu?Ala?Val?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Arg
130?????????????????135?????????????????140
Ser?Leu?Arg?Gly?Ser?Arg?Thr?Gly?Val?Phe?Val?Gly?Thr?Asn?Gly?Gln
145?????????????????150?????????????????155?????????????????160
Asp?Tyr?Ala?Tyr?Leu?Leu?Val?Arg?Ser?Leu?Ala?Asp?Ala?Thr?Gly?Asp
165?????????????????170?????????????????175
Ile?Gly?Thr?Gly?Ile?Ala?Ala?Ser?Ala?Thr?Ser?Gly?Arg?Leu?Ser?Tyr
180?????????????????185?????????????????190
Thr?Leu?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp?Thr?Ala?Cys?Ser
195?????????????????200?????????????????205
Ser?Ser?Leu?Val?Ala?Leu?His?Ala?Ala?Ala?His?Ala?Leu?Arg?Ala?Gly
210?????????????????215?????????????????220
Glu?Cys?Gly?Leu?Ala?Leu?Ala?Gly?Gly?Val?Asn?Val?Met?Ser?Ala?Pro
225?????????????????230?????????????????235?????????????????240
Gly?Ser?Leu?Met?Glu?Phe?Ser?Arg?Ala?Gly?Gly?Leu?Ala?Gly?Asp?Gly
245?????????????????250?????????????????255
Arg?Cys?Lys?Ala?Phe?Ala?Asp?Glu?Ala?Asp?Gly?Thr?Gly?Trp?Ser?Glu
260?????????????????265?????????????????270
Gly?Val?Gly?Val?Leu?Leu?Leu?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn
275?????????????????280?????????????????285
Gly?His?Pro?Val?Leu?Ala?Val?Leu?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp
290?????????????????295?????????????????300
Gly?Ala?Ser?Asn?Gly?Phe?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg
305?????????????????310?????????????????315?????????????????320
Val?Ile?Gln?Gln?Ala?Leu?Ala?Ala?Ala?Gly?Leu?Thr?Ala?Ala?Asp?Val
325?????????????????330?????????????????335
Asp?Ala?Val?Glu?Gly?His?Gly?Thr?Gly?Thr?Pro?Leu?Gly?Asp?Pro?Ile
340?????????????????345?????????????????350
Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Gly?Arg?Pro?Glu?Asp
355?????????????????360?????????????????365
Arg?Pro?Leu?Leu?Leu?Gly?Ser?Val?Lys?Ser?Asn?Ile?Gly?His?Ala?Gln
370?????????????????375?????????????????380
Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Ile?Met?Ala?Met?Arg
385?????????????????390?????????????????395?????????????????400
His?Gly?Val?Val?Pro?Arg?Ser?Leu?His?Ala?Asp?His?Pro?Ser?Arg?His
405?????????????????410?????????????????415
Val?Asp?Trp?Asp?Ser?Gly?Ala?Val?Arg?Leu?Leu?Ser?Glu?Ala?Val?Glu
420?????????????????425?????????????????430
Trp?Pro?Glu?Thr?Gly?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ser?Phe?Gly
435?????????????????440?????????????????445
Ile?Ser?Gly?Thr?Asn?Ala?His?Val?Val?Ile?Glu?Gln?Ala?Gly?Pro?Ala
450?????????????????455?????????????????460
Ala?Glu?Pro?Glu?Ser?Pro?Ala?Glu?Pro?Glu?Thr?Val?Pro?Thr?Val?Val
465?????????????????470?????????????????475?????????????????480
Pro?Trp?Pro?Val?His?Ala?Arg?Ser?Glu?Ala?Ser?Leu?Asp?Ala?Gln?Ile
485?????????????????490?????????????????495
Glu?Ala?Val?Thr?Ala?Leu?Thr?Asp?Ala?Thr?Pro?Leu?Asp?Ile?Gly?His
500?????????????????505?????????????????510
Ser?Leu?Ala?Thr?Gly?Arg?Ser?Leu?Phe?Glu?His?Arg?Ala?Val?Leu?Leu
515?????????????????520?????????????????525
Ser?Gly?Leu?Asp?Gly?Val?Pro?Ala?Glu?Ala?Ala?Arg?Gly?Arg?Ala?Thr
530?????????????????535?????????????????540
Glu?Arg?Ser?Leu?Ala?Val?Leu?Phe?Ser?Gly?Gln?Gly?Ala?Gln?Arg?Ala
545?????????????????550?????????????????555?????????????????560
Glu?Met?Gly?Arg?Glu?Leu?Tyr?Ala?Arg?Phe?Pro?Val?Phe?Ala?Lys?Ala
565?????????????????570?????????????????575
Leu?Asp?Glu?Ile?Thr?Ala?Leu?Leu?Asp?Pro?Arg?Leu?Asp?Arg?Pro?Leu
580?????????????????585?????????????????590
Arg?Glu?Val?Met?Phe?Ala?Arg?Arg?Arg?Thr?Pro?Glu?Ala?Ala?Leu?Leu
595?????????????????600?????????????????605
Asp?Thr?Thr?Gly?Tyr?Thr?Gln?Pro?Ala?Leu?Phe?Ala?Val?Glu?Val?Ala
610?????????????????615?????????????????620
Leu?His?Arg?Leu?Val?Glu?Ser?Trp?Gly?Val?Val?Pro?Asp?Phe?Val?Ala
625?????????????????630?????????????????635?????????????????640
Gly?His?Ser?Ile?Gly?Glu?Ile?Ala?Ala?Ala?His?Val?Ala?Gly?Val?Phe
645?????????????????650?????????????????655
Ser?Leu?Glu?Asp?Ala?Cys?Thr?Leu?Val?Ala?Ala?Arg?Ala?Arg?Leu?Met
660?????????????????665?????????????????670
Gln?Glu?Leu?Pro?Ala?Gly?Gly?Ala?Met?Val?Ala?Val?Gln?Ala?Thr?Glu
675?????????????????680?????????????????685
Ala?Glu?Ala?Ala?Pro?Arg?Leu?Thr?Glu?Gly?Val?Ala?Leu?Ala?Ala?Val
690?????????????????695?????????????????700
Asn?Gly?Pro?Asp?Ser?Val?Thr?Leu?Ala?Gly?Glu?Glu?Ala?Gln?Val?Leu
705?????????????????710?????????????????715?????????????????720
Ala?Leu?Ala?Ala?Glu?Phe?Ala?Ala?Glu?Gly?Arg?Lys?Thr?Gln?Arg?Leu
725?????????????????730?????????????????735
Ala?Val?Ser?His?Ala?Phe?His?Ser?Pro?Leu?Met?Glu?Pro?Met?Leu?Ala
740?????????????????745?????????????????750
Glu?Phe?Arg?Arg?Val?Ala?Glu?Ser?Leu?Thr?Tyr?His?Glu?Pro?Val?Leu
755?????????????????760?????????????????765
Pro?Val?Val?Ser?Asn?Val?Thr?Gly?Ala?Leu?Ala?Asp?Asp?Arg?Leu?Leu
770?????????????????775?????????????????780
Cys?Asp?Pro?Glu?Tyr?Trp?Val?Asp?His?Val?Arg?Ser?Thr?Val?Arg?Phe
785?????????????????790?????????????????795?????????????????800
Ala?Asp?Gly?Val?Arg?Ala?Leu?Ala?Gly?Ala?Gly?Ala?Asp?Thr?Phe?Val
805?????????????????810?????????????????815
Glu?Leu?Gly?Pro?Asp?Gly?Ile?Leu?Thr?Ala?Leu?Ala?Gln?Gln?Cys?Leu
820?????????????????825?????????????????830
Asp?Gly?Pro?Asp?Val?Val?Ala?Val?Pro?Val?Leu?Arg?Lys?Asp?Arg?Ala
835?????????????????840?????????????????845
Glu?Glu?Arg?Ala?Leu?Leu?Thr?Ala?Leu?Ala?Arg?Leu?His?Val?Ala?Gly
850?????????????????855?????????????????860
Val?Asp?Ile?Asp?Trp?Ala?Ala?Cys?Phe?Glu?Gly?Thr?Gly?Ala?Arg?Arg
865?????????????????870?????????????????875?????????????????880
Thr?Glu?Leu?Pro?Thr?Tyr?Arg?Trp?Gln?His?Glu?Arg?Tyr?Trp?Pro?Val
885?????????????????890?????????????????895
Leu?Met?Ala?Ala?Ala?Gly?Asp?Val?Ser?Ala?Ala?Gly?Leu?Val?Ser?Ala
900?????????????????905?????????????????910
Glu?His?Pro?Leu?Leu?Gly?Ala?Ala?Val?Ser?Leu?Ala?Gly?Ser?Asp?Gly
915?????????????????920?????????????????925
Val?Leu?Phe?Thr?Gly?Arg?Leu?Ser?Ala?Gln?Thr?His?Pro?Trp?Leu?Leu
930?????????????????935?????????????????940
Asp?His?Thr?Val?Gly?Gly?Met?Val?Ala?Phe?Pro?Gly?Thr?Gly?Phe?Leu
945?????????????????950?????????????????955?????????????????960
Glu?Leu?Ala?Val?Arg?Ala?Gly?Asp?Gln?Val?Gly?Cys?Asp?Arg?Val?Glu
965?????????????????970?????????????????975
Asp?Leu?Thr?Leu?Ala?Lys?Pro?Leu?Ile?Leu?Thr?Glu?Asn?Ser?Ala?Ala
980?????????????????985?????????????????990
Val?Val?Gln?Val?His?Val?Gly?Ala?Ala?Asp?Ala?Asp?Gly?Ala?Arg?Arg
995?????????????????1000????????????????1005
Val?Thr?Val?Tyr?Ser?Gln?Ala?Val?Asp?Asp?Pro?Glu?Gln?Arg?Trp
1010????????????????1015????????????????1020
Thr?Glu?His?Ala?Ser?Gly?Leu?Leu?Thr?Arg?Gly?Glu?Arg?Val?Thr
1025????????????????1030????????????????1035
Gly?Phe?Asp?Ser?Thr?Val?Trp?Pro?Pro?Arg?Gly?Ala?Val?Ala?Ala
1040????????????????1045????????????????1050
Asp?Leu?Glu?Gly?Phe?Tyr?Ala?Arg?Thr?Glu?Tyr?Gly?Pro?Val?Phe
1055????????????????1060????????????????1065
Gln?Gly?Leu?Arg?Ala?Val?Trp?Thr?Arg?Asp?Asp?Glu?Ala?Phe?Val
1070????????????????1075????????????????1080
Glu?Val?Ala?Leu?Pro?Pro?Gln?Val?Asp?Asp?Ala?Glu?Tyr?Tyr?Gly
1085????????????????1090????????????????1095
Met?His?Pro?Ala?Leu?Leu?Asp?Ala?Ala?Val?Gln?Ser?Val?Gly?Phe
1100????????????????1105????????????????1110
Ala?Gly?Leu?Gly?Asp?Gly?Lys?Lys?Leu?Val?Pro?Phe?Ser?Trp?Ser
1115????????????????1120????????????????1125
Gly?Val?Ser?Leu?His?Ala?Gly?Gly?Ala?Ser?Val?Val?Arg?Val?Arg
1130????????????????1135????????????????1140
Val?Ala?Arg?Val?Gly?Glu?Asp?Thr?Val?Ser?Ile?Ala?Ala?Val?Asp
1145????????????????1150????????????????1155
Val?Glu?Gly?Ala?Pro?Val?Leu?Ser?Ala?Asp?Ser?Leu?Ile?Leu?Arg
1160????????????????1165????????????????1170
Ala?Pro?Ser?Ala?Leu?Arg?Ala?Pro?Thr?Leu?His?Ser?Ser?Glu?Gln
1175????????????????1180????????????????1185
Asp?Gly?Leu?Leu?Arg?Leu?Glu?Trp?Val?Ala?Ala?Pro?Glu?Gly?Gly
1190????????????????1195????????????????1200
Ala?Ala?Pro?Val?Arg?Ala?Val?Thr?Leu?Gly?Thr?Asp?Arg?Ala?Trp
1205????????????????1210????????????????1215
Pro?Gly?Pro?Leu?Ala?Ser?Leu?Ala?Asp?Ala?Ala?Ala?Val?Thr?Pro
1220????????????????1225????????????????1230
Ala?Pro?Asp?Leu?Val?Leu?Val?Pro?Leu?Glu?Gly?Val?Glu?Asp?Asp
1235????????????????1240????????????????1245
Thr?Pro?Thr?Ala?Val?His?Ala?Ala?Thr?Ala?Arg?Thr?Leu?Ala?Leu
1250????????????????1255????????????????1260
Ile?Gln?Glu?Trp?Leu?Glu?Pro?Ala?Thr?Ser?Ala?Ala?Gly?Arg?Leu
1265????????????????1270????????????????1275
Val?Phe?Val?Thr?Arg?Gly?Ala?Val?Ala?Thr?Gly?Thr?Asp?Thr?Gly
1280????????????????1285????????????????1290
Val?Ser?Asp?Leu?Ala?Ala?Ala?Ala?Val?His?Gly?Leu?Val?Arg?Ser
1295????????????????1300????????????????1305
Ala?Glu?Ala?Glu?Asn?Pro?Gly?Arg?Phe?Ala?Leu?Leu?Asp?Leu?Asp
1310????????????????1315????????????????1320
Ala?Gly?Thr?Ala?Ala?Pro?Ser?Gly?Glu?Leu?Leu?Ala?Gln?Leu?Pro
1325????????????????1330????????????????1335
Pro?Leu?Leu?Ala?Ala?Gly?Asp?Thr?Gln?Phe?Ala?Val?Arg?Asp?Glu
1340????????????????1345????????????????1350
Ala?Val?Leu?Val?Ala?Arg?Leu?Ala?Arg?Leu?Ser?Thr?Gly?Ala?Ser
1355????????????????1360????????????????1365
Leu?Leu?Pro?Val?Pro?Gly?Leu?Pro?Trp?Arg?Leu?Asp?Thr?Thr?Val
1370????????????????1375????????????????1380
Pro?Gly?Ser?Ile?Asp?Gly?Leu?Ser?Leu?Val?Pro?Ala?Pro?Glu?Ala
1385????????????????1390????????????????1395
Leu?Asp?Glu?Pro?Glu?Gly?Arg?Ala?Val?Arg?Val?Glu?Val?Arg?Ala
1400????????????????1405????????????????1410
Ala?Gly?Leu?Asn?Phe?Arg?Asp?Val?Leu?Asn?Ala?Leu?Gly?Met?Tyr
1415????????????????1420????????????????1425
Pro?Gly?Glu?Ala?Gly?Leu?Leu?Gly?Ser?Glu?Ala?Val?Gly?Leu?Val
1430????????????????1435????????????????1440
Thr?Ala?Val?Gly?Pro?Asp?Val?Thr?Gly?Ile?Ala?Val?Gly?Asp?Arg
1445????????????????1450????????????????1455
Val?Thr?Gly?Met?Ile?Pro?Gly?Gly?Leu?Ala?Asp?Thr?Val?Leu?Val
1460????????????????1465????????????????1470
Asp?Glu?Arg?Tyr?Val?Thr?Arg?Val?Pro?Glu?Glu?Trp?Ser?Asp?Glu
1475????????????????1480????????????????1485
Asp?Ala?Ala?Ser?Val?Pro?Leu?Val?Phe?Leu?Thr?Ala?Leu?Tyr?Ala
1490????????????????1495????????????????1500
Phe?Arg?Asp?Leu?Ala?Ser?Val?Gln?Ala?Gly?Glu?Arg?Val?Leu?Ile
1505????????????????1510????????????????1515
His?Ala?Gly?Ala?Gly?Gly?Val?Gly?Met?Ala?Ala?Ile?Gln?Leu?Ala
1520????????????????1525????????????????1530
Arg?His?Met?Gly?Ala?Glu?Val?Phe?Ala?Thr?Ala?Ser?Glu?Pro?Lys
1535????????????????1540????????????????1545
Trp?Glu?Thr?Leu?Arg?Gly?Leu?Gly?Leu?Asp?Asp?Ala?His?Ile?Ala
1550????????????????1555????????????????1560
Ser?Ser?Arg?Asp?Leu?Gly?Phe?Glu?Glu?Lys?Phe?Arg?Glu?Val?Thr
1565????????????????1570????????????????1575
Gly?Gly?Ala?Gly?Met?Asp?Val?Val?Leu?Asn?Ala?Leu?Ala?Gly?Asp
1580????????????????1585????????????????1590
Phe?Val?Asp?Ala?Ser?Leu?Arg?Ile?Thr?Ala?Pro?Gly?Gly?Arg?Phe
1595????????????????1600????????????????1605
Leu?Glu?Met?Gly?Lys?Thr?Asp?Ile?Arg?Asp?Pro?Gln?Thr?Thr?Gly
1610????????????????1615????????????????1620
Glu?Val?Arg?Tyr?Arg?Ala?Phe?Asp?Leu?Gly?Glu?Ala?Ala?Pro?Glu
1625????????????????1630????????????????1635
Arg?Ile?Gly?Glu?Met?Leu?Thr?Glu?Leu?Leu?Gly?Leu?Phe?Ala?Glu
1640????????????????1645????????????????1650
Gly?Ala?Leu?Gln?Pro?Leu?Pro?Val?Arg?Ala?Trp?Asp?Val?Arg?Arg
1655????????????????1660????????????????1665
Ala?Arg?Glu?Ala?Phe?Arg?Phe?Met?Ser?Gln?Ala?Arg?His?Val?Gly
1670????????????????1675????????????????1680
Lys?Ile?Val?Leu?Thr?Met?Pro?Pro?Arg?Trp?Asn?Pro?Glu?Gly?Thr
1685????????????????1690????????????????1695
Val?Leu?Val?Thr?Gly?Gly?Thr?Gly?Gly?Leu?Gly?Arg?Glu?Val?Ala
1700????????????????1705????????????????1710
Arg?His?Leu?Val?Ser?Ala?Arg?Gly?Val?Arg?Arg?Leu?Leu?Leu?Val
1715????????????????1720????????????????1725
Ser?Arg?Arg?Gly?Pro?Ala?Ala?Glu?Gly?Val?Asp?Ala?Phe?Arg?Glu
1730????????????????1735????????????????1740
Glu?Leu?Ala?Gly?Leu?Gly?Ala?His?Val?Asp?Val?Val?Ala?Cys?Asp
1745????????????????1750????????????????1755
Val?Ala?Asp?Arg?Ala?Ala?Val?Ala?Gly?Leu?Leu?Gly?Ser?Val?Pro
1760????????????????1765????????????????1770
Val?Gly?His?Pro?Leu?Thr?Ala?Val?Val?His?Thr?Ala?Gly?Val?Leu
1775????????????????1780????????????????1785
Asp?Asp?Gly?Val?Val?Thr?Gly?Leu?Ser?Pro?Glu?Arg?Leu?Ser?Gly
1790????????????????1795????????????????1800
Val?Leu?Arg?Pro?Lys?Val?Asp?Ala?Ala?Trp?His?Leu?His?Glu?Leu
1805????????????????1810????????????????1815
Thr?Arg?Asp?Met?Gly?Leu?Ala?Gly?Phe?Val?Met?Phe?Ser?Ser?Val
1820????????????????1825????????????????1830
Ser?Gly?Val?Met?Gly?Ser?Ala?Gly?Gln?Ala?Asn?Tyr?Ala?Ala?Ala
1835????????????????1840????????????????1845
Asn?Val?Phe?Met?Asp?Ala?Leu?Ala?Gln?Tyr?Arg?Arg?Ala?Glu?Gly
1850????????????????1855????????????????1860
Leu?Ala?Gly?Leu?Ser?Leu?Ala?Trp?Gly?Ala?Trp?Glu?Gln?Thr?Ser
1865????????????????1870????????????????1875
Gly?Met?Thr?Gly?Thr?Leu?Thr?Glu?Ala?Asp?Met?Gln?Arg?Val?Thr
1880????????????????1885????????????????1890
Ala?Ser?Gly?Ala?Ala?Pro?Leu?Thr?Val?Glu?Gln?Gly?Leu?Ala?Leu
1895????????????????1900????????????????1905
Leu?Asp?Ala?Ala?Thr?Gly?Ser?Asp?Glu?Pro?Leu?Val?Val?Pro?Ile
1910????????????????1915????????????????1920
Gly?Ala?Pro?Ser?Gly?Asp?Gln?Arg?Val?Leu?Gly?Leu?Val?Pro?Pro
1925????????????????1930????????????????1935
Leu?Leu?Arg?Asn?Leu?Val?Arg?Gly?Thr?Arg?Arg?Ser?Ala?Ala?Thr
1940????????????????1945????????????????1950
Ala?Ala?Gly?Gly?Ala?Ser?Thr?Ala?Ala?Asp?Leu?Ala?Arg?Arg?Leu
1955????????????????1960????????????????1965
Leu?Ala?Leu?Pro?Ala?Glu?Asp?Arg?Val?Arg?His?Ala?Val?Glu?Leu
1970????????????????1975????????????????1980
Val?Arg?Thr?Glu?Ala?Ala?Ala?Val?Leu?Gly?His?Ala?Ser?Ala?Arg
1985????????????????1990????????????????1995
Ala?Val?Glu?Pro?Gly?Arg?Glu?Phe?Arg?Glu?Leu?Gly?Phe?Asp?Ser
2000????????????????2005????????????????2010
Leu?Thr?Ala?Val?Glu?Leu?Arg?Asn?Arg?Leu?Thr?Thr?Val?Thr?Gly
2015????????????????2020????????????????2025
Leu?Arg?Leu?Thr?Ala?Thr?Leu?Val?Phe?Asp?Tyr?Pro?Thr?Pro?His
2030????????????????2035????????????????2040
Gly?Leu?Ala?Glu?His?Leu?Val?Ala?Glu?Leu?Leu?Asp?Glu?His?Gly
2045????????????????2050????????????????2055
Glu?Thr?Gly?Thr?Pro?Val?Val?Ala?Ala?Asp?Val?Ala?Asp?Asp?Pro
2060????????????????2065????????????????2070
Val?Val?Ile?Val?Gly?Met?Ala?Cys?Arg?Met?Pro?Gly?Gly?Ile?Glu
2075????????????????2080????????????????2085
Thr?Pro?Asp?Asp?Leu?Trp?Arg?Met?Leu?Ala?Asp?Gly?Glu?Asp?Arg
2090????????????????2095????????????????2100
Ile?Thr?Gly?Phe?Pro?Thr?Asp?Arg?Gly?Trp?Asp?Leu?Asp?Ala?Leu
2105????????????????2110????????????????2115
Phe?Gly?Gly?Gly?Gly?Asp?Asn?Arg?Gly?Val?Ser?Ala?Thr?Arg?Arg
2120????????????????2125????????????????2130
Gly?Gly?Phe?Leu?His?Asp?Val?Gly?Gly?Phe?Asp?Ala?Gly?Phe?Phe
2135????????????????2140????????????????2145
Gly?Ile?Ser?Pro?Arg?Glu?Ala?Met?Ala?Met?Asp?Pro?Gln?Gln?Arg
2150????????????????2155????????????????2160
Leu?Leu?Leu?Glu?Thr?Ser?Trp?Glu?Ala?Leu?Glu?Arg?Ser?Gly?Ile
2165????????????????2170????????????????2175
Asp?Pro?Thr?Gly?Leu?Arg?Ser?Ser?Ala?Thr?Gly?Ile?Phe?Val?Gly
2180????????????????2185????????????????2190
Thr?Thr?Gly?Gln?Asp?Tyr?Ala?Asn?Leu?Val?Met?Thr?Ser?Arg?Glu
2195????????????????2200????????????????2205
Asp?Val?Glu?Gly?His?Ala?Ser?Thr?Gly?Leu?Ala?Thr?Ser?Val?Ile
2210????????????????2215????????????????2220
Ser?Gly?Arg?Val?Ser?Tyr?Ala?Leu?Gly?Leu?Glu?Gly?Pro?Ala?Leu
2225????????????????2230????????????????2235
Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His?Leu
2240????????????????2245????????????????2250
Ala?Ala?Gln?Ser?Leu?Arg?Ser?Gly?Glu?Ser?Ser?Leu?Ala?Leu?Ala
2255????????????????2260????????????????2265
Gly?Gly?Val?Thr?Val?Leu?Ser?Thr?Pro?Met?Asn?Phe?Phe?Gly?Phe
2270????????????????2275????????????????2280
Thr?Arg?Gln?Gly?Gly?Leu?Ala?Gly?Asp?Gly?Leu?Cys?Lys?Ala?Phe
2285????????????????2290????????????????2295
Ala?Asp?Ala?Ala?Asp?Gly?Thr?Gly?Trp?Ser?Glu?Gly?Val?Gly?Met
2300????????????????2305????????????????2310
Leu?Val?Leu?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Asp
2315????????????????2320????????????????2325
Val?Leu?Ala?Val?Val?Arg?Gly?Ser?Ala?Ile?Asn?Gln?Asp?Gly?Ala
2330????????????????2335????????????????2340
Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val
2345????????????????2350????????????????2355
Ile?Arg?Gln?Ala?Leu?Ala?Thr?Ala?Gly?Leu?Ser?Ala?Asp?Glu?Val
2360????????????????2365????????????????2370
Asp?Ala?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp?Pro
2375????????????????2380????????????????2385
Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Asp?Arg?Pro
2390????????????????2395????????????????2400
Glu?Asp?Arg?Pro?Leu?Leu?Leu?Gly?Ser?Ile?Lys?Ser?Asn?Ile?Gly
2405????????????????2410????????????????2415
His?Thr?Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Val
2420????????????????2425????????????????2430
Leu?Ala?Met?Arg?His?Gly?Ala?Leu?Pro?Arg?Ser?Leu?His?Ile?Asp
2435????????????????2440????????????????2445
Gln?Pro?Ser?Thr?His?Val?Asp?Trp?Glu?Ala?Gly?Ala?Val?Arg?Leu
2450????????????????2455????????????????2460
Leu?Thr?Glu?Thr?Thr?Gly?Trp?Pro?Glu?Thr?Gly?Arg?Pro?Trp?Arg
2465????????????????2470????????????????2475
Ala?Gly?Val?Ser?Ser?Phe?Gly?Leu?Ser?Gly?Thr?Asn?Ala?His?Val
2480????????????????2485????????????????2490
Ile?Leu?Glu?Gln?Pro?Glu?Pro?Glu?Thr?Ala?Asp?Thr?Glu?Ser?Pro
2495????????????????2500????????????????2505
Glu?Pro?Gln?Ala?Glu?Pro?Glu?Ala?Leu?Ala?Arg?Val?Val?Pro?Trp
2510????????????????2515????????????????2520
Pro?Val?Ser?Ala?Arg?Thr?Glu?Glu?Ala?Leu?Pro?Gly?Gln?Leu?Ala
2525????????????????2530????????????????2535
Arg?Ile?Thr?Ala?Leu?Asp?Ala?Ala?Pro?Leu?Asp?Ile?Gly?His?Ser
2540????????????????2545????????????????2550
Leu?Ala?Thr?Gly?Arg?Ala?Ser?Phe?Asp?His?Arg?Val?Val?Leu?Leu
2555????????????????2560????????????????2565
Ala?Gly?Ala?Asp?Gly?Glu?Asp?Glu?Pro?Val?Glu?Val?Ala?Arg?Gly
2570????????????????2575????????????????2580
Arg?Ala?Val?Glu?Arg?Arg?Leu?Ala?Val?Leu?Phe?Ser?Gly?Gln?Gly
2585????????????????2590????????????????2595
Ser?Gln?Arg?Ala?Gly?Met?Gly?Arg?Glu?Leu?Tyr?Gly?Arg?Phe?Pro
2600????????????????2605????????????????2610
Val?Phe?Thr?Lys?Ala?Leu?Asp?Glu?Val?Leu?Ala?Leu?Leu?Asp?Pro
2615????????????????2620????????????????2625
Lys?Leu?Asp?Arg?Pro?Leu?Arg?Glu?Val?Leu?Phe?Ala?Glu?Glu?Gly
2630????????????????2635????????????????2640
Ser?Glu?Thr?Ala?Ala?Leu?Leu?Asp?Thr?Thr?Gly?Tyr?Thr?Gln?Pro
2645????????????????2650????????????????2655
Ala?Leu?Phe?Ala?Val?Glu?Val?Ala?Leu?Tyr?Arg?Leu?Val?Glu?Ser
2660????????????????2665????????????????2670
Phe?Gly?Val?Val?Pro?Glu?Phe?Val?Ala?Gly?His?Ser?Val?Gly?Glu
2675????????????????2680????????????????2685
Ile?Ser?Ala?Ala?His?Ile?Ala?Gly?Val?Leu?Ser?Leu?Glu?Asp?Ala
2690????????????????2695????????????????2700
Cys?Thr?Leu?Val?Ala?Ala?Arg?Ala?Arg?Leu?Met?Gln?Glu?Leu?Pro
2705????????????????2710????????????????2715
Ala?Gly?Gly?Ala?Met?Val?Ala?Val?Gln?Ala?Thr?Glu?Ala?Glu?Thr
2720????????????????2725????????????????2730
Ala?Gly?Arg?Leu?Thr?Gly?Gly?Leu?Ser?Leu?Ala?Ala?Val?Asn?Gly
2735????????????????2740????????????????2745
Pro?Asp?Ser?Val?Val?Ile?Ala?Gly?Pro?Asp?His?Glu?Val?Asp?Ala
2750????????????????2755????????????????2760
Leu?Ala?Ser?Glu?Phe?Ala?Ala?Glu?Gly?Arg?Lys?Val?Gln?Arg?Leu
2765????????????????2770????????????????2775
Ala?Val?Ser?His?Ala?Phe?His?Ser?Ala?Leu?Met?Glu?Pro?Met?Leu
2780????????????????2785????????????????2790
Asp?Ala?Phe?His?Asp?Val?Ala?Lys?Gly?Leu?Gly?Tyr?Gly?Glu?Pro
2795????????????????2800????????????????2805
Arg?Ile?Pro?Val?Val?Ser?Asp?Val?Thr?Gly?Thr?Leu?Ala?Glu?Pro
2810????????????????2815????????????????2820
Gly?Gln?Leu?Ser?Arg?Pro?Glu?Tyr?Trp?Val?Glu?His?Val?Arg?Ser
2825????????????????2830????????????????2835
Thr?Val?Arg?Phe?Ala?Asp?Ala?Val?His?Ala?Leu?Asp?Gln?Ala?Gly
2840????????????????2845????????????????2850
Ala?Asn?Ala?Tyr?Leu?Glu?Ile?Gly?Pro?Gly?Gly?Val?Leu?Thr?Val
2855????????????????2860????????????????2865
Leu?Ala?Gln?Gln?Thr?Leu?Asp?Ala?Ala?Gly?Thr?Ala?Ser?Asp?Ser
2870????????????????2875????????????????2880
Val?Thr?Ala?Pro?Ala?Leu?Arg?Lys?Asp?Arg?Ala?Glu?Glu?Pro?Ala
2885????????????????2890????????????????2895
Leu?Leu?Thr?Ala?Leu?Ala?Thr?Leu?His?Val?Thr?Gly?Val?Pro?Val
2900????????????????2905????????????????2910
Asp?Trp?Ala?Gly?Cys?Phe?Glu?Gly?Thr?Gly?Ala?Arg?Arg?Val?Glu
2915????????????????2920????????????????2925
Leu?Pro?Thr?Tyr?Ala?Phe?Gln?His?Glu?Arg?Tyr?Trp?Pro?Arg?Pro
2930????????????????2935????????????????2940
Ser?Ala?His?Gly?Gly?Asp?Val?Thr?Gly?Ala?Gly?Leu?Ser?Pro?Ala
2945????????????????2950????????????????2955
Ala?His?Pro?Leu?Leu?Gly?Ala?Ala?Thr?Gly?Leu?Ala?Ala?Ser?Glu
2960????????????????2965????????????????2970
Gly?Val?Leu?Phe?Thr?Gly?Arg?Leu?Ser?Leu?Thr?Thr?His?Pro?Trp
2975????????????????2980????????????????2985
Leu?Ala?Asp?His?Thr?Val?Gly?Gly?Gly?Met?Val?Leu?Phe?Pro?Ala
2990????????????????2995????????????????3000
Thr?Gly?Phe?Leu?Glu?Leu?Ala?Val?Arg?Ala?Ala?Asp?Glu?Val?Gly
3005????????????????3010????????????????3015
Cys?Asp?Arg?Val?Glu?Glu?Phe?Thr?Leu?Ala?Thr?Pro?Leu?Leu?Leu
3020????????????????3025????????????????3030
Pro?Ala?Asp?Thr?Ala?Val?Val?Val?Gln?Val?Trp?Ala?Gly?Ala?Pro
3035????????????????3040????????????????3045
Asp?Glu?Ser?Gly?Ala?Arg?Thr?Val?Ser?Leu?Tyr?Ser?Arg?Ser?Ala
3050????????????????3055????????????????3060
Asp?Val?Pro?Asp?Ala?Thr?Trp?Thr?Gln?His?Ala?Thr?Gly?Val?Leu
3065????????????????3070????????????????3075
Thr?Ser?Gly?Ala?Val?Thr?Leu?Pro?Ala?Val?Ala?Glu?Ile?Trp?Pro
3080????????????????3085????????????????3090
Pro?Lys?Gly?Ala?Val?Ala?Val?Gly?Leu?Glu?Asp?Phe?Tyr?Asp?Arg
3095????????????????3100????????????????3105
Thr?Glu?Tyr?Gly?Pro?Val?Phe?Arg?Thr?Ile?Arg?Ala?Val?Trp?Lys
3110????????????????3115????????????????3120
Arg?Gly?Asp?Glu?Ala?Phe?Val?Glu?Ala?Ala?Leu?Pro?Pro?Gln?Ala
3125????????????????3130????????????????3135
Asp?Asp?Ala?Glu?Tyr?Tyr?Gly?Met?His?Pro?Ala?Leu?Leu?Asp?Ala
3140????????????????3145????????????????3150
Ala?Val?Gln?Ser?Val?Gly?Phe?Ala?Gly?Leu?Asp?Asp?Glu?His?Gln
3155????????????????3160????????????????3165
Leu?Leu?Pro?Phe?Leu?Trp?Ala?Gly?Val?Ser?Leu?His?Ala?Gly?Gly
3170????????????????3175????????????????3180
Ala?Ser?Val?Val?Arg?Phe?Arg?Val?Ala?Arg?Thr?Gly?Glu?Asp?Ser
3185????????????????3190????????????????3195
Val?Ser?Ile?Ala?Ala?Val?Asp?Val?Glu?Gly?Ala?Pro?Val?Leu?Ser
3200????????????????3205????????????????3210
Ala?Glu?Ser?Leu?Val?Leu?Arg?Val?Pro?Ala?Gly?Asp?His?Ala?Pro
3215????????????????3220????????????????3225
Ala?Ala?Arg?Arg?Thr?Glu?Leu?Asp?Ser?Leu?Leu?Arg?Leu?Glu?Trp
3230????????????????3235????????????????3240
Thr?Ala?Gly?Pro?Glu?Thr?Gly?Asp?Ala?Pro?Ala?Ala?Arg?His?Thr
3245????????????????3250????????????????3255
Thr?Ala?Gly?Ala?Leu?Gly?Thr?Gly?Gly?Ala?Ala?Ala?Thr?Leu?Ala
3260????????????????3265????????????????3270
Pro?Leu?Thr?Gly?Glu?Glu?Asp?Leu?Val?Leu?Val?Glu?Val?Pro?Ala
3275????????????????3280????????????????3285
Pro?Ala?Glu?Gly?Ala?Asp?Val?Pro?Ala?Ala?Thr?His?Glu?Arg?Ala
3290????????????????3295????????????????3300
Ala?Gln?Ala?Leu?Ala?Leu?Ala?Gln?Glu?Trp?Leu?Ala?Asp?Glu?Arg
3305????????????????3310????????????????3315
Phe?Ala?Asp?Thr?Arg?Leu?Val?Phe?Val?Thr?Arg?Gly?Ala?Val?Cys
3320????????????????3325????????????????3330
Ala?Arg?Pro?Gly?Glu?Arg?Val?Asp?Asp?Leu?Pro?Ala?Ala?Ala?Val
3335????????????????3340????????????????3345
Trp?Gly?Leu?Val?Arg?Ala?Ala?Gln?Ser?Glu?Asn?Pro?Thr?Arg?Phe
3350????????????????3355????????????????3360
Ala?Leu?Leu?Asp?Leu?Asp?Asp?Thr?Thr?Pro?Val?Glu?Thr?Ala?Leu
3365????????????????3370????????????????3375
Pro?Gln?Leu?Leu?Gly?Pro?Leu?Ser?Gly?Gly?Asp?Ala?Gln?Phe?Val
3380????????????????3385????????????????3390
Val?Arg?Glu?Gly?Ala?Val?Leu?Val?Gly?Arg?Leu?Asp?Arg?Ala?Val
3395????????????????3400????????????????3405
Thr?Ala?Pro?Ser?Leu?Leu?Pro?Pro?Ala?Asp?Gly?Pro?Trp?Arg?Leu
3410????????????????3415????????????????3420
Asp?Ser?Pro?Ser?Arg?Gly?Ser?Leu?Asp?Ala?Leu?Thr?Leu?Arg?Pro
3425????????????????3430????????????????3435
Cys?Pro?Glu?Glu?Leu?Ala?Glu?Pro?Gln?Glu?Arg?Gln?Val?Arg?Val
3440????????????????3445????????????????3450
Glu?Val?Arg?Ala?Ala?Gly?Leu?Asn?Phe?Arg?Asp?Val?Leu?Asn?Ala
3455????????????????3460????????????????3465
Leu?Gly?Met?Tyr?Pro?Gly?Glu?Ala?Gly?Leu?Leu?Gly?Ala?Glu?Ala
3470????????????????3475????????????????3480
Ala?Gly?Phe?Val?Thr?Ala?Val?Gly?Pro?Glu?Val?Thr?Gly?Leu?Ser
3485????????????????3490????????????????3495
Val?Gly?Asp?Arg?Val?Met?Gly?Met?Val?Pro?Gly?Gly?Leu?Ala?Thr
3500????????????????3505????????????????3510
Glu?Thr?Leu?Ile?Asp?Glu?Arg?Phe?Leu?Thr?Arg?Val?Pro?Glu?Glu
3515????????????????3520????????????????3525
Trp?Ser?Asp?Glu?Asp?Ala?Ala?Ser?Val?Pro?Leu?Val?Phe?Leu?Thr
3530????????????????3535????????????????3540
Ala?Tyr?Tyr?Ala?Leu?Thr?Glu?Leu?Ala?Gly?Leu?Ser?Ala?Gly?Glu
3545????????????????3550????????????????3555
Arg?Val?Leu?Ile?His?Ala?Gly?Ala?Gly?Gly?Val?Gly?Met?Ala?Ala
3560????????????????3565????????????????3570
Ile?Gln?Leu?Ala?Arg?His?Met?Gly?Ala?Glu?Val?Phe?Ala?Thr?Ala
3575????????????????3580????????????????3585
Ser?Glu?Pro?Lys?Trp?Glu?Thr?Leu?Arg?Gly?Leu?Gly?Leu?Asp?Asp
3590????????????????3595????????????????3600
Ala?His?Ile?Ala?Ser?Ser?Arg?Asp?Leu?Gly?Phe?Glu?Glu?Lys?Phe
3605????????????????3610????????????????3615
Arg?Glu?Glu?Thr?Gly?Gly?Ala?Gly?Met?Asp?Val?Val?Leu?Asn?Ala
3620????????????????3625????????????????3630
Leu?Ala?Gly?Asp?Phe?Val?Asp?Ala?Ser?Leu?Arg?Ile?Thr?Ala?Ser
3635????????????????3640????????????????3645
Gly?Gly?Arg?Phe?Leu?Glu?Met?Gly?Lys?Thr?Asp?Ile?Arg?Asp?Pro
3650????????????????3655????????????????3660
His?Ala?Val?Gly?Asp?Val?Arg?Tyr?Arg?Ala?Phe?Asp?Leu?Gly?Glu
3665????????????????3670????????????????3675
Ala?Gly?Pro?Asp?Arg?Thr?Gly?Glu?Met?Leu?Ser?Glu?Leu?Leu?Gly
3680????????????????3685????????????????3690
Leu?Phe?Ala?Glu?Gly?Ala?Leu?Arg?Pro?Leu?Pro?Val?Arg?Ala?Trp
3695????????????????3700????????????????3705
Asp?Val?Arg?Arg?Ala?Arg?Glu?Ala?Phe?Arg?Phe?Met?Ser?Gln?Ala
3710????????????????3715????????????????3720
Arg?His?Val?Gly?Lys?Ile?Val?Leu?Thr?Met?Pro?Pro?Arg?Trp?Asn
3725????????????????3730????????????????3735
Pro?Glu?Gly?Thr?Val?Leu?Val?Thr?Gly?Gly?Thr?Gly?Gly?Leu?Gly
3740????????????????3745????????????????3750
Arg?Glu?Val?Ala?Arg?His?Leu?Val?Ser?Ala?Arg?Gly?Val?Arg?Arg
3755????????????????3760????????????????3765
Leu?Leu?Leu?Val?Ser?Arg?Arg?Gly?Pro?Ala?Ala?Glu?Gly?Val?Asp
3770????????????????3775????????????????3780
Ala?Phe?Arg?Glu?Glu?Leu?Ala?Gly?Leu?Gly?Ala?His?Val?Asp?Val
3785????????????????3790????????????????3795
Val?Ala?Cys?Asp?Val?Ala?Asp?Arg?Ala?Ala?Val?Ala?Gly?Leu?Leu
3800????????????????3805????????????????3810
Ala?Ser?Val?Pro?Val?Gly?His?Pro?Leu?Thr?Ala?Val?Val?His?Thr
3815????????????????3820????????????????3825
Ala?Gly?Val?Leu?Asp?Asp?Gly?Val?Val?Thr?Gly?Leu?Ser?Pro?Glu
3830????????????????3835????????????????3840
Arg?Leu?Ser?Gly?Val?Leu?Arg?Pro?Lys?Val?Asp?Ala?Ala?Trp?His
3845????????????????3850????????????????3855
Leu?His?Glu?Leu?Thr?Arg?Asp?Met?Gly?Leu?Ala?Gly?Phe?Val?Met
3860????????????????3865????????????????3870
Phe?Ser?Ser?Val?Ser?Gly?Val?Met?Gly?Ser?Ala?Gly?Gln?Gly?Asn
3875????????????????3880????????????????3885
Tyr?Ala?Ala?Ala?Asn?Val?Phe?Met?Asp?Ala?Leu?Ala?Gln?Tyr?Arg
3890????????????????3895????????????????3900
Arg?Ala?Glu?Gly?Leu?Ala?Gly?Leu?Ser?Leu?Ala?Trp?Gly?Ala?Trp
3905????????????????3910????????????????3915
Glu?Gln?Thr?Ser?Gly?Met?Thr?Gly?Thr?Leu?Thr?Asp?Ala?Gly?Val
3920????????????????3925????????????????3930
Arg?Arg?Met?Ser?Ala?Ser?Ala?Ala?Pro?Ala?Leu?Thr?Val?Glu?Gln
3935????????????????3940????????????????3945
Gly?Leu?Ala?Leu?Leu?Asp?Ala?Ala?Val?Val?Ser?Asp?Glu?Pro?His
3950????????????????3955????????????????3960
Leu?Val?Pro?Leu?Gly?Ala?Ser?Gly?Ser?Thr?Arg?Met?Pro?Gly?Glu
3965????????????????3970????????????????3975
Val?Pro?Pro?Leu?Leu?Arg?Asn?Leu?Val?Arg?Gly?Thr?Arg?Arg?Ala
3980????????????????3985????????????????3990
Ala?Ala?Thr?Ala?Val?Gly?Gly?Ala?Gly?Thr?Ala?Asp?Glu?Leu?Thr
3995????????????????4000????????????????4005
Arg?Arg?Leu?Leu?Asp?Leu?Arg?Glu?Asp?Glu?Arg?Leu?Arg?Phe?Ala
4010????????????????4015????????????????4020
Val?Asn?Leu?Ile?Arg?Ala?Glu?Ala?Ala?Ser?Val?Leu?Gly?His?Ser
4025????????????????4030????????????????4035
Ser?Ala?Gln?Ala?Ile?Asp?Ala?Glu?Arg?Asp?Phe?His?Asp?Leu?Gly
4040????????????????4045????????????????4050
Phe?Asp?Ser?Leu?Thr?Ala?Val?Glu?Leu?Arg?Asn?Arg?Leu?Thr?Gly
4055????????????????4060????????????????4065
Ala?Thr?Gly?Leu?Arg?Leu?Pro?Ala?Thr?Leu?Val?Phe?Asp?His?Pro
4070????????????????4075????????????????4080
Thr?Pro?Gly?Val?Leu?Ala?Glu?His?Leu?Ile?Ala?Ala?Leu?Leu?Asp
4085????????????????4090????????????????4095
Glu?Gln?Arg?Ala?Thr?Gly?Ala?Thr?Ala?Pro?Thr?Pro?Val?Ala?Ala
4100????????????????4105????????????????4110
Ala?Leu?Ala?Glu?Asp?Pro?Val?Val?Ile?Val?Gly?Met?Ala?Cys?Arg
4115????????????????4120????????????????4125
Met?Pro?Gly?Gly?Val?Ser?Ser?Pro?Glu?Glu?Leu?Trp?Gln?Leu?Val
4130????????????????4135????????????????4140
Leu?Asp?Gly?Gln?Glu?Gly?Ile?Ser?Ala?Phe?Pro?Thr?Asp?Arg?Gly
4145????????????????4150????????????????4155
Trp?Asp?Leu?Asp?Thr?Leu?Gln?Arg?Gly?Gly?Glu?Ser?Gly?His?Gly
4160????????????????4165????????????????4170
Arg?Ser?Ala?Thr?Ser?Glu?Gly?Gly?Phe?Leu?Tyr?Asp?Val?Ala?Asp
4175????????????????4180????????????????4185
Phe?Asp?Ala?Gly?Phe?Phe?Gly?Ile?Ser?Pro?Arg?Glu?Ala?Leu?Ala
4190????????????????4195????????????????4200
Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu?Thr?Thr?Trp?Glu?Ala
4205????????????????4210????????????????4215
Phe?Glu?Arg?Ala?Gly?Ile?Thr?Pro?Thr?Glu?Val?Arg?Gly?Ser?Arg
4220????????????????4225????????????????4230
Thr?Gly?Val?Phe?Val?Gly?Thr?Ser?Gly?Gln?Asp?Tyr?Thr?Thr?Leu
4235????????????????4240????????????????4245
Val?Met?Asn?Ser?Arg?Gln?Asp?Ala?Glu?Gly?His?Ala?Pro?Thr?Gly
4250????????????????4255????????????????4260
Leu?Ala?Thr?Ser?Val?Ile?Ser?Gly?Arg?Leu?Ser?Tyr?Thr?Phe?Gly
4265????????????????4270????????????????4275
Leu?Glu?Gly?Pro?Ala?Val?Thr?Ile?Asp?Thr?Ala?Cys?Ser?Ser?Ser
4280????????????????4285????????????????4290
Leu?Val?Ala?Leu?His?Trp?Ala?Ala?His?Ala?Leu?Arg?Ser?Gly?Glu
4295????????????????4300????????????????4305
Ala?Asp?Leu?Ala?Leu?Ala?Gly?Gly?Val?Thr?Val?Met?Ser?Thr?Ala
4310????????????????4315????????????????4320
Met?Gly?Tyr?Ala?Gly?Phe?Thr?Arg?Gln?Gly?Gly?Leu?Ala?Thr?Asp
4325????????????????4330????????????????4335
Gly?Arg?Cys?Lys?Ala?Phe?Ala?Asp?Ala?Ala?Asp?Gly?Thr?Gly?Trp
4340????????????????4345????????????????4350
Ser?Glu?Gly?Val?Gly?Met?Leu?Val?Val?Glu?Arg?Leu?Ser?Asp?Ala
4355????????????????4360????????????????4365
Arg?Arg?Asn?Gly?His?Pro?Val?Leu?Ala?Val?Leu?Arg?Gly?Ser?Ala
4370????????????????4375????????????????4380
Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly
4385????????????????4390????????????????4395
Pro?Ser?Gln?Gln?Arg?Val?Ile?Arg?Gln?Ala?Leu?Ala?Ser?Ala?Gly
4400????????????????4405????????????????4410
Leu?Ser?Thr?Asp?Glu?Val?Asp?Ala?Val?Glu?Ala?His?Gly?Thr?Gly
4415????????????????4420????????????????4425
Thr?Thr?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr
4430????????????????4435????????????????4440
Tyr?Gly?Gln?Asp?Arg?Pro?Gly?Asp?Arg?Pro?Leu?Leu?Leu?Gly?Ser
4445????????????????4450????????????????4455
Ile?Lys?Ser?Asn?Ile?Gly?His?Ala?Gln?Ala?Ala?Ala?Gly?Val?Ala
4460????????????????4465????????????????4470
Gly?Val?Ile?Lys?Thr?Val?Met?Ala?Ile?Arg?His?Gly?Val?Leu?Pro
4475????????????????4480????????????????4485
Arg?Ser?Leu?His?Ile?Asp?Arg?Pro?Ser?Thr?His?Val?Asp?Trp?Thr
4490????????????????4495????????????????4500
Glu?Gly?Asp?Val?Arg?Leu?Leu?Thr?Glu?Thr?Thr?Glu?Trp?Pro?Glu
4505????????????????4510????????????????4515
Thr?Gly?Arg?Pro?Arg?Arg?Ala?Ala?Val?Ser?Ser?Phe?Gly?Ile?Ser
4520????????????????4525????????????????4530
Gly?Thr?Asn?Ala?His?Thr?Ile?Ile?Glu?Gln?Ala?Pro?Glu?Ile?Val
4535????????????????4540????????????????4545
Glu?Ala?Thr?Pro?Ala?Ala?Ala?Ser?Ala?Pro?Ala?Pro?Ala?Ala?Val
4550????????????????4555????????????????4560
Pro?Trp?Pro?Val?Ser?Ala?Lys?Ser?Pro?Glu?Ala?Leu?Asp?Ala?Gln
4565????????????????4570????????????????4575
Leu?Ala?Arg?Ile?Ala?Thr?Val?Thr?Gly?Ala?Thr?Pro?Leu?Asp?Ile
4580????????????????4585????????????????4590
Gly?His?Ser?Leu?Ala?Thr?Gly?Arg?Ala?Ser?Phe?Glu?Tyr?Arg?Ala
4595????????????????4600????????????????4605
Val?Leu?Leu?Ala?Gly?Thr?Gly?Ala?Glu?Asp?Glu?Pro?Val?Glu?Val
4610????????????????4615????????????????4620
Ala?Arg?Gly?Arg?Ala?Val?Glu?Arg?Arg?Leu?Ala?Val?Leu?Phe?Pro
4625????????????????4630????????????????4635
Gly?Gln?Gly?Ser?Gln?Arg?Ala?Gly?Met?Gly?Arg?Glu?Leu?Tyr?Glu
4640????????????????4645????????????????4650
Arg?Tyr?Pro?Val?Phe?Ala?Lys?Ala?Leu?Asp?Glu?Ile?Thr?Ala?Leu
4655????????????????4660????????????????4665
Leu?Asp?Pro?Glu?Leu?Asp?Arg?Pro?Leu?Arg?Glu?Val?Leu?Phe?Ala
4670????????????????4675????????????????4680
Glu?Glu?Gly?Ser?Glu?Thr?Ala?Ala?Leu?Leu?Asp?Thr?Thr?Gly?Tyr
4685????????????????4690????????????????4695
Thr?Gln?Pro?Ala?Leu?Phe?Ala?Val?Glu?Val?Ala?Leu?His?Arg?Leu
4700????????????????4705????????????????4710
Leu?Glu?Ser?Gln?Gly?Val?Ser?Pro?Glu?Tyr?Val?Ala?Gly?His?Ser
4715????????????????4720????????????????4725
Val?Gly?Glu?Ile?Ala?Ala?Ala?His?Val?Ala?Gly?Val?Phe?Ser?Leu
4730????????????????4735????????????????4740
Glu?Asp?Ala?Cys?Arg?Leu?Val?Ala?Ala?Arg?Ala?Arg?Leu?Met?Gln
4745????????????????4750????????????????4755
Glu?Leu?Pro?Ala?Gly?Gly?Ala?Met?Ala?Ala?Val?Gln?Ala?Thr?Glu
4760????????????????4765????????????????4770
Ala?Glu?Ile?Ala?Pro?Arg?Leu?Thr?Glu?Gly?Leu?Ser?Leu?Ala?Ala
4775????????????????4780????????????????4785
Val?Asn?Gly?Pro?Asp?Ser?Val?Val?Val?Ser?Gly?Pro?Glu?Ser?Glu
4790????????????????4795????????????????4800
Val?Thr?Ala?Leu?Ala?Ala?Glu?Phe?Val?Ala?Glu?Gly?Arg?Lys?Thr
4805????????????????4810????????????????4815
Gln?Arg?Leu?Gln?Val?5er?His?Ala?Phe?His?Ser?Ala?Leu?Thr?Glu
4820????????????????4825????????????????4830
Pro?Met?Leu?Asp?Ala?Phe?Arg?Glu?Val?Ala?Arg?Ser?Leu?Ala?Tyr
4835????????????????4840????????????????4845
Ala?Glu?Pro?Arg?Leu?Pro?Val?Val?Ser?Asn?Val?Thr?Gly?Ala?Leu
4850????????????????4855????????????????4860
Ala?Ala?Pro?Gly?Gln?Leu?Thr?Asp?Pro?Glu?Tyr?Trp?Val?Arg?His
4865????????????????4870????????????????4875
Val?Arg?Glu?Thr?Val?Arg?Phe?Ala?Asp?Gly?Val?Arg?Ala?Leu?Ala
4880????????????????4885????????????????4890
Glu?Ala?Gly?Ala?Asp?Ala?Tyr?Leu?Glu?Ala?Gly?Pro?Gly?Gly?Val
4895????????????????4900????????????????4905
Leu?Thr?Ala?Leu?Ala?Arg?Gln?Thr?Leu?Gly?Thr?Asp?Ser?Glu?Ala
4910????????????????4915????????????????4920
Val?Thr?Ala?Pro?Ala?Leu?Arg?Lys?Asp?Arg?Ala?Glu?Glu?Pro?Ala
4925????????????????4930????????????????4935
Leu?Leu?Thr?Ala?Leu?Ala?Thr?Leu?His?Val?Thr?Gly?Val?Pro?Val
4940????????????????4945????????????????4950
Asp?Trp?Ala?Ala?Cys?Phe?Glu?Gly?Thr?Gly?Ala?Arg?Arg?Val?Asp
4955????????????????4960????????????????4965
Leu?Pro?Thr?Tyr?Ala?Phe?Gln?Arg?Val?Arg?His?Trp?Pro?Asp?Thr
4970????????????????4975????????????????4980
Arg?Arg?Pro?Gly?Thr?Gly?Gly?Gly?Ser?Ser?Asp?Pro?Leu?Asp?Gly
4985????????????????4990????????????????4995
Ala?Phe?Trp?Thr?Ala?Val?Glu?Gly?Glu?Asp?Leu?Thr?Arg?Leu?Ala
5000????????????????5005????????????????5010
Thr?Asp?Leu?Ala?Val?Asp?Thr?Glu?Ala?Leu?Gly?Ala?Val?Leu?Pro
5015????????????????5020????????????????5025
Ala?Leu?Ser?Thr?Trp?Arg?Arg?Arg?Arg?Arg?Asp?Gln?Ala?Met?Val
5030????????????????5035????????????????5040
Asp?Ser?Asn?Arg?His?His?Glu?Thr?Trp?Lys?Pro?Leu?Ser?Leu?Pro
5045????????????????5050????????????????5055
Pro?Gly?Ala?Pro?Ala?Pro?Ala?Gly?Thr?Trp?Leu?Ala?Val?Val?Pro
5060????????????????5065????????????????5070
Ala?Ala?Tyr?Gly?Glu?Asp?Pro?Trp?Thr?Ala?Ala?Val?Leu?Asp?Ala
5075????????????????5080????????????????5085
Val?Gly?Thr?Asp?Val?Val?Arg?Leu?Thr?Val?Asp?Thr?Val?Glu?Arg
5090????????????????5095????????????????5100
His?Ala?Leu?Ala?Asp?Arg?Leu?Arg?Ala?Leu?Ser?Ala?Asp?Gly?Ala
5105????????????????5110????????????????5115
Ala?Leu?Ala?Gly?Val?Val?Ser?Leu?Leu?Ala?Leu?Ala?Asp?Thr?Pro
5120????????????????5125????????????????5130
Glu?Ala?Ala?Val?Ser?Gly?Asp?Pro?Ala?Gly?Ala?Pro?Ala?Ala?Pro
5135????????????????5140????????????????5145
Thr?Ala?Val?Leu?Phe?Gln?Ala?Leu?Leu?Asp?Ala?Gly?Val?Asp?Ala
5150????????????????5155????????????????5160
Pro?Leu?Trp?Cys?Leu?Thr?Arg?Gly?Ala?Val?Ala?Val?Ala?Gly?Ser
5165????????????????5170????????????????5175
Glu?Ala?Val?Thr?Ala?Pro?Ala?Gln?Ala?Ala?Val?Trp?Gly?Leu?Gly
5180????????????????5185????????????????5190
Arg?Val?Ala?Ala?Leu?Glu?His?Pro?Ala?Val?Trp?Gly?Gly?Leu?Val
5195????????????????5200????????????????5205
Asp?Leu?Pro?Ser?Ala?Trp?Asp?Glu?Arg?Ala?Ala?Arg?Arg?Phe?Ala
5210????????????????5215????????????????5220
Ala?Val?Leu?Ala?Gly?His?Asp?Gly?Glu?Asp?Gln?Val?Ala?Val?Arg
5225????????????????5230????????????????5235
Ser?Ser?Ala?Ala?Phe?Ala?Arg?Arg?Leu?Val?Pro?Ala?Pro?Ala?Ala
5240????????????????5245????????????????5250
Glu?Pro?Gly?Asp?Gly?Trp?Gln?Pro?Arg?Gly?Thr?Val?Leu?Val?Thr
5255????????????????5260????????????????5265
Gly?Gly?Thr?Gly?Gly?Arg?Gly?Ala?His?Val?Ala?Arg?Trp?Leu?Ala
5270????????????????5275????????????????5280
Gly?Ala?Gly?Ala?Ala?His?Leu?Val?Leu?Leu?Gly?Arg?Arg?Gly?Pro
5285????????????????5290????????????????5295
Asp?Ala?Pro?Gly?Ala?Asp?Ala?Leu?Arg?Ala?Glu?Leu?Glu?Ala?Ala
5300????????????????5305????????????????5310
Gly?Ala?Arg?Val?Thr?Leu?Val?Ala?Cys?Asp?Ala?Ala?Asp?Arg?Asp
5315????????????????5320????????????????5325
Ala?Leu?Ala?Ala?Val?Leu?Asp?Gly?Ile?Pro?Ala?Asp?Thr?Pro?Leu
5330????????????????5335????????????????5340
Ser?Ala?Val?Val?His?Ala?Ala?Ala?Val?Val?Asp?Asp?Gly?Val?Leu
5345????????????????5350????????????????5355
Asp?Asp?Leu?Thr?Pro?Glu?Arg?Phe?Ala?Ala?Pro?His?His?Ala?Arg
5360????????????????5365????????????????5370
Thr?Ala?Pro?Ala?Leu?His?Leu?Asp?Glu?Leu?Thr?Arg?Gly?Leu?Asp
5375????????????????5380????????????????5385
Leu?Asp?Val?Phe?Ala?Leu?Cys?Ser?Ser?Val?Ala?Gly?Thr?Val?Gly
5390????????????????5395????????????????5400
Thr?Ala?Gly?Arg?Ala?Asn?Leu?Ala?Ala?Ala?Thr?Ala?Val?Leu?Asp
5405????????????????5410????????????????5415
Ala?Leu?Ala?Arg?Ser?Arg?Arg?Ser?Glu?Gly?Leu?Pro?Ala?Thr?Ser
5420????????????????5425????????????????5430
Met?Ala?Trp?Gly?Ala?Trp?Ile?Gly?Asp?Ala?Asp?Glu?Thr?Gly?Gly
5435????????????????5440????????????????5445
Asp?Asp?Ala?Pro?Ala?Ala?Pro?Arg?Ala?Gly?Ala?Gly?His?Pro?Ala
5450????????????????5455????????????????5460
Val?His?Pro?Asp?Leu?Ala?Leu?Ala?Ala?Leu?Arg?Gln?Ala?Val?Thr
5465????????????????5470????????????????5475
Arg?Pro?Glu?Ala?Ala?Pro?Val?Leu?Phe?Asp?Pro?Arg?Gln?Pro?Gln
5480????????????????5485????????????????5490
Val?Leu?Asp?Gly?Leu?Ile?Gly?Met?Arg?Gly?Asn?Ala?Leu?Leu?Arg
5495????????????????5500????????????????5505
Asp?Leu?Pro?Asp?Ala?Arg?Gln?Ala?Leu?Ala?Asp?Ala?Glu?Thr?Thr
5510????????????????5515????????????????5520
Arg?Asp?Arg?Ala?Arg?Thr?Ala?Ala?Ser?Gly?Leu?Ala?Glu?Arg?Leu
5525????????????????5530????????????????5535
Arg?Gly?Leu?Pro?Ala?Asp?Glu?Arg?Thr?Asp?Ser?Val?Thr?Glu?Leu
5540????????????????5545????????????????5550
Val?Arg?Thr?His?Ala?Ala?Ala?Val?Leu?Gly?His?Pro?Gly?Pro?Glu
5555????????????????5560????????????????5565
Ala?Val?Ala?Ala?Asp?Arg?Asn?Phe?Arg?Asp?Leu?Gly?Phe?Asp?Ser
5570????????????????5575????????????????5580
Leu?Thr?Ala?Ile?Glu?Leu?Pro?Asn?Arg?Ile?Ala?Leu?Ala?Thr?Gly
5585????????????????5590????????????????5595
Leu?Arg?Leu?Pro?Ala?Thr?Thr?Val?Tyr?Asp?Tyr?Pro?Thr?Ala?Gln
5600????????????????5605????????????????5610
Ala?Leu?Ala?Glu?His?Leu?Leu?Ala?Glu?Leu?Leu?Gly?Glu?Gln?Asp
5615????????????????5620????????????????5625
Thr?Pro?Gly?Ser?Gly?Arg?Ala?Thr?Pro?Ala?Ala?Leu?Ala?Glu?Asp
5630????????????????5635????????????????5640
Pro?Val?Val?Ile?Val?Gly?Met?Ala?Cys?Arg?Leu?Pro?Gly?Gly?Val
5645????????????????5650????????????????5655
Arg?Ser?Pro?Gln?Asp?Leu?Trp?Ala?Met?Val?Ser?Glu?Gly?Arg?Asp
5660????????????????5665????????????????5670
Gly?Ile?Glu?Ala?Phe?Pro?Glu?Asp?Arg?Gly?Trp?Asp?Leu?Ala?Thr
5675????????????????5680????????????????5685
Leu?Thr?Thr?Gly?Gly?Ala?Asp?Gly?Arg?Gly?Arg?Ser?Ala?Thr?Leu
5690????????????????5695????????????????5700
Arg?Gly?Gly?Phe?Leu?Ser?Gly?Ala?Ala?Asp?Phe?Asp?Ala?Ala?Phe
5705????????????????5710????????????????5715
Phe?Gly?Ile?Ser?Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln
5720????????????????5725????????????????5730
Arg?Leu?Leu?Leu?Glu?Thr?Thr?Trp?Glu?Ala?Phe?Glu?Arg?Ser?Gly
5735????????????????5740????????????????5745
Ile?Asp?Ala?Asp?Gln?Leu?Arg?Gly?Ser?Arg?Thr?Gly?Val?Phe?Val
5750????????????????5755????????????????5760
Gly?Thr?Asn?Gly?Gln?Asp?Tyr?Ser?Thr?Leu?Val?Met?Asn?Ser?Arg
5765????????????????5770????????????????5775
Glu?Asp?Leu?Glu?Gly?His?Ala?Gly?Thr?Gly?Leu?Ala?Ala?Ser?Val
5780????????????????5785????????????????5790
Val?Ser?Gly?Arg?Leu?Ala?Tyr?Thr?Phe?Gly?Leu?Glu?Gly?Pro?Ala
5795????????????????5800????????????????5805
Val?Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His
5810????????????????5815????????????????5820
Trp?Ala?Met?Gln?Ala?Leu?Arg?Ala?Gly?Glu?Cys?Asp?Leu?Ala?Val
5825????????????????5830????????????????5835
Ala?Gly?Gly?Ile?Thr?Met?Met?Ser?Thr?Pro?Ser?Ala?Phe?Ser?Gly
5840????????????????5845????????????????5850
Phe?Thr?Leu?Gln?Asn?Gly?Leu?Ala?Val?Asp?Gly?Arg?Cys?Lys?Ala
5855????????????????5860????????????????5865
Tyr?Ala?Asp?Ala?Ala?Asp?Gly?Thr?Gly?Trp?Ser?Glu?Gly?Val?Gly
5870????????????????5875????????????????5880
Leu?Ile?Val?Val?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His
5885????????????????5890????????????????5895
Glu?Val?Leu?Ala?Val?Val?Arg?Gly?Ser?Ala?Ile?Asn?Gln?Asp?Gly
5900????????????????5905????????????????5910
Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg
5915????????????????5920????????????????5925
Val?Ile?Arg?Gln?Ala?Leu?Ala?Gly?Gly?Gly?Leu?Thr?Pro?Ser?Asp
5930????????????????5935????????????????5940
Ile?Asp?Ala?Val?Glu?Gly?His?Gly?Thr?Gly?Thr?Pro?Leu?Gly?Asp
5945????????????????5950????????????????5955
Pro?Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Asp?Arg
5960????????????????5965????????????????5970
Pro?Ala?Asp?Arg?Pro?Leu?Leu?Leu?Gly?Ser?Ile?Lys?Ser?Asn?Ile
5975????????????????5980????????????????5985
Gly?His?Thr?Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly?Ile?Ile?Lys?Thr
5990????????????????5995????????????????6000
Val?Met?Ala?Met?Arg?His?Gly?Val?Leu?Pro?Arg?Thr?Leu?His?Val
6005????????????????6010????????????????6015
Asp?Arg?Pro?Ser?Thr?His?Val?Asp?Trp?Glu?Ser?Gly?Ala?Ile?Arg
6020????????????????6025????????????????6030
Leu?Leu?Thr?Glu?Glu?Ser?Ala?Trp?Pro?Asp?Ser?Gly?Arg?Pro?Trp
6035????????????????6040????????????????6045
Arg?Ala?Gly?Ile?Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr?Asn?Ala?His
6050????????????????6055????????????????6060
Thr?Ile?Ile?Glu?Gln?Ala?Pro?Ala?Pro?Glu?Pro?Ala?Glu?Pro?Gly
6065????????????????6070????????????????6075
Ala?Ala?Leu?Leu?Pro?Gly?Pro?Thr?Pro?Thr?Val?Val?Pro?Trp?Pro
6080????????????????6085????????????????6090
Val?Ser?Ala?Lys?Ser?Glu?Glu?Ala?Leu?Asp?Gly?Gln?Ile?Ala?Ala
6095????????????????6100????????????????6105
Val?Thr?Ala?Leu?Asp?Gly?Ala?Ala?Pro?Leu?Asp?Val?Gly?His?Ser
6110????????????????6115????????????????6120
Leu?Ala?Thr?Gly?Arg?Ala?Arg?Phe?Asp?His?Arg?Ala?Val?Leu?Leu
6125????????????????6130????????????????6135
Ala?Arg?Pro?Gly?Thr?Thr?Pro?Trp?Glu?Ala?Ala?Arg?Gly?Arg?Ala
6140????????????????6145????????????????6150
Ala?Val?Arg?Ser?Leu?Ala?Leu?Leu?Phe?Ser?Gly?Gln?Gly?Ser?Gln
6155????????????????6160????????????????6165
Arg?Ala?Gly?Met?Gly?Arg?Glu?Leu?Tyr?Asp?Arg?Phe?Pro?Val?Phe
6170????????????????6175????????????????6180
Ala?Glu?Ala?Leu?Asp?Ala?Val?Leu?Ala?Arg?Leu?Asp?Thr?Gly?Leu
6185????????????????6190????????????????6195
Thr?Pro?Ser?Leu?Arg?Glu?Val?Leu?Phe?Ala?Glu?Glu?Gly?Ser?Gly
6200????????????????6205????????????????6210
Thr?Ala?Ala?Leu?Leu?Asp?Thr?Thr?Gly?Tyr?Thr?Gln?Pro?Ala?Leu
6215????????????????6220????????????????6225
Phe?Ala?Val?Glu?Val?Ala?Leu?Tyr?Arg?Leu?Val?Glu?Ser?Trp?Gly
6230????????????????6235????????????????6240
Val?Arg?Pro?Gly?His?Val?Ala?Gly?His?Ser?Val?Gly?Glu?Ile?Ala
6245????????????????6250????????????????6255
Ala?Ala?His?Val?Ala?Gly?Val?Phe?Ser?Leu?Glu?Asp?Ala?Cys?Arg
6260????????????????6265????????????????6270
Leu?Val?Ala?Ala?Arg?Ala?Arg?Leu?Met?Gln?Glu?Leu?Pro?Ser?Gly
6275????????????????6280????????????????6285
Gly?Ala?Met?Val?Ala?Val?Arg?Ala?Thr?Glu?Ala?Glu?Val?Val?Pro
6290????????????????6295????????????????6300
Arg?Leu?Thr?Glu?Gly?Leu?Ser?Leu?Ala?Ala?Val?Asn?Gly?Pro?Asp
6305????????????????6310????????????????6315
Ser?Val?Val?Ile?Ala?Gly?Thr?Glu?Asp?Glu?Ala?Leu?Ala?Leu?Ala
6320????????????????6325????????????????6330
Glu?Ala?Phe?Ala?Ala?Glu?Gly?Arg?Lys?Thr?Gln?Arg?Leu?Pro?Val
6335????????????????6340????????????????6345
Ser?His?Ala?Phe?His?Ser?Pro?Leu?Met?Glu?Pro?Met?Leu?Asp?Ala
6350????????????????6355????????????????6360
Phe?Arg?Gln?Val?Ala?Glu?Ser?Leu?Glu?Tyr?Ala?Glu?Pro?Arg?Ile
6365????????????????6370????????????????6375
Pro?Val?Val?Ser?Asp?Val?Thr?Gly?Ala?Leu?Ala?Glu?Pro?Gly?Gln
6380????????????????6385????????????????6390
Leu?Thr?Arg?Ala?Ala?Tyr?Trp?Val?Glu?His?Val?Arg?Ala?Thr?Val
6395????????????????6400????????????????6405
Arg?Phe?Ala?Asp?Gly?Val?Arg?Ala?Leu?Ala?Gly?Ala?Gly?Ala?Asn
6410????????????????6415????????????????6420
Ala?Phe?Leu?Glu?Ile?Gly?Pro?Gly?Gly?Val?Leu?Thr?Ala?Leu?Ala
6425????????????????6430????????????????6435
Gln?Ser?Val?Leu?Glu?Ala?Asp?Asp?Arg?Asp?Glu?Ala?Val?Val?Leu
6440????????????????6445????????????????6450
Pro?Ala?Leu?Arg?Lys?Asp?Arg?Asp?Glu?Glu?Thr?Ala?Leu?Leu?Thr
6455????????????????6460????????????????6465
Ala?Val?Ala?Gly?Leu?His?Val?Ser?Gly?Val?Arg?Val?Asp?Trp?Ser
6470????????????????6475????????????????6480
Ala?Trp?Phe?Thr?Gly?Thr?Gly?Ala?Arg?Arg?Thr?Glu?Leu?Pro?Thr
6485????????????????6490????????????????6495
Tyr?Ala?Phe?Gln?Arg?Glu?Arg?Tyr?Trp?Pro?Arg?Pro?Ala?Ala?Leu
6500????????????????6505????????????????6510
Thr?Gly?Asp?Ile?Ser?Thr?Ala?Gly?Leu?Ile?Ser?Ala?Glu?His?Pro
6515????????????????6520????????????????6525
Leu?Leu?Gly?Ala?Ala?Val?Pro?Leu?Ala?Asp?Ser?Glu?Gly?Val?Leu
6530????????????????6535????????????????6540
Phe?Thr?Ser?Gln?Ile?Ser?Met?Gln?Val?His?Pro?Trp?Leu?Leu?Asp
6545????????????????6550????????????????6555
His?Arg?Val?Gly?Gly?Thr?Val?Ile?Met?Pro?Gly?Thr?Gly?Tyr?Leu
6560????????????????6565????????????????6570
Glu?Met?Ala?Ile?Arg?Ala?Ala?Asp?Gln?Val?Gly?Cys?Ala?Arg?Val
6575????????????????6580????????????????6585
Glu?Glu?Leu?Val?Leu?Ala?Ala?Pro?Met?Val?Leu?Asp?Glu?Lys?His
6590????????????????6595????????????????6600
Pro?Val?Ser?Val?Gln?Val?Val?Val?Gly?Ala?Pro?Asp?Asp?Thr?Gly
6605????????????????6610????????????????6615
Thr?Arg?Pro?Val?Thr?Phe?Tyr?Ser?Arg?Pro?Ser?Asp?Ala?Val?Asp
6620????????????????6625????????????????6630
Ala?Pro?Trp?Ser?Arg?His?Ala?Asp?Gly?Phe?Leu?Ala?Val?Gln?Glu
6635????????????????6640????????????????6645
Arg?Thr?Asp?Ser?Phe?Glu?Ala?Pro?Val?Trp?Pro?Pro?Ala?Asp?Ala
6650????????????????6655????????????????6660
Val?Ser?Val?Glu?Phe?Asp?Gly?Asp?Tyr?Ser?Arg?Thr?Gly?Tyr?Gly
6665????????????????6670????????????????6675
Pro?Ser?Phe?Gln?Gly?Leu?Arg?Gln?Val?Trp?Leu?Arg?Gly?Glu?Glu
6680????????????????6685????????????????6690
Ala?Phe?Val?Glu?Val?Ala?Leu?Pro?Glu?Glu?Val?Ala?Gly?Asp?Ala
6695????????????????6700????????????????6705
Gln?Tyr?Phe?Gly?Met?His?Pro?Ala?Leu?Leu?Asp?Ala?Val?Gln?His
6710????????????????6715????????????????6720
Ala?Asn?Gly?Tyr?Leu?Gly?Val?Gly?Ser?Glu?Glu?Asn?Pro?Leu?Leu
6725????????????????6730????????????????6735
Pro?Phe?Ala?Trp?Asn?Gly?Val?Ser?Leu?His?Ala?Arg?Gly?Ala?Thr
6740????????????????6745????????????????6750
Thr?Leu?Arg?Val?Arg?Ile?Thr?Arg?Leu?Gly?Asp?Glu?Ser?Val?Arg
6755????????????????6760????????????????6765
Leu?Thr?Ala?Val?Asp?Ala?Glu?Gly?Val?Pro?Val?Leu?Cys?Ala?Glu
6770????????????????6775????????????????6780
Ser?Leu?Val?Leu?Arg?Ala?Pro?Thr?Val?Pro?Ser?Ala?Pro?Val?Ala
6785????????????????6790????????????????6795
Thr?Gly?Gly?Gln?Glu?Pro?Val?Phe?Arg?Leu?Asp?Trp?Thr?Ala?Ala
6800????????????????6805????????????????6810
Pro?Ala?Val?Lys?Pro?Thr?Glu?Gly?Leu?Thr?Ala?Ala?Thr?Leu?Gly
6815????????????????6820????????????????6825
Glu?Asp?Val?Phe?Gly?Val?Gly?Thr?Ala?Leu?Ala?Ser?Leu?Thr?Glu
6830????????????????6835????????????????6840
Leu?Thr?Gly?Pro?Asp?Ala?Asp?Pro?Ser?Ala?Ala?Pro?Asp?Phe?Val
6845????????????????6850????????????????6855
Leu?Val?Pro?Leu?Ala?Gly?Ala?Gly?Asp?Ala?Ala?Gly?Ala?Gly?Asp
6860????????????????6865????????????????6870
Pro?Asp?Ala?His?Gly?Ala?Asp?Val?Pro?Ala?Ala?Val?His?Ala?Leu
6875????????????????6880????????????????6885
Thr?Thr?Arg?Thr?Leu?Asp?Leu?Leu?Gln?Gln?Trp?Gln?Ala?Ala?Glu
6890????????????????6895????????????????6900
Arg?Leu?Gly?His?Ser?Arg?Leu?Val?Phe?Val?Thr?Thr?Gly?Ala?Val
6905????????????????6910????????????????6915
Ala?Ala?His?Asp?Thr?Glu?Thr?Val?Arg?Asp?Leu?Ala?Ala?Gly?Ala
6920????????????????6925????????????????6930
Ala?Trp?Gly?Leu?Val?Arg?Ser?Ala?Gln?Ser?Glu?Asn?Pro?Asp?Arg
6935????????????????6940????????????????6945
Phe?Val?Leu?Leu?Asp?Leu?Asp?Gly?Ala?Asp?Ala?Pro?Asp?Thr?Leu
6950????????????????6955????????????????6960
Arg?Ala?Leu?Leu?Pro?Asp?Leu?Pro?Gly?Leu?Leu?Gly?Ser?Gly?Asp
6965????????????????6970????????????????6975
Ala?Gln?Phe?Ala?Val?Arg?Glu?Gly?Thr?Ala?Leu?Val?Gly?Arg?Leu
6980????????????????6985????????????????6990
Glu?Arg?Leu?Thr?Thr?Ala?Pro?Gly?Leu?Leu?Ala?Pro?Thr?Gly?Thr
6995????????????????7000????????????????7005
Pro?Trp?Arg?Leu?Asp?Thr?Thr?Gly?Lys?Gly?Ser?Leu?Asp?Asn?Leu
7010????????????????7015????????????????7020
Val?Leu?Ala?Pro?Cys?Pro?Glu?Val?Leu?Gln?Pro?Leu?Gly?Ala?His
7025????????????????7030????????????????7035
Glu?Val?Arg?Ile?Asp?Val?Glu?Ala?Ala?Gly?Leu?Asn?Phe?Arg?Asp
7040????????????????7045????????????????7050
Val?Leu?Asn?Ala?Leu?Gly?Met?Tyr?Pro?Gly?Glu?Ser?Gly?Pro?Met
7055????????????????7060????????????????7065
Gly?Thr?Glu?Ala?Ala?Gly?Val?Val?Thr?Ala?Val?Gly?Glu?Ala?Val
7070????????????????7075????????????????7080
Thr?Gly?Leu?Ala?Pro?Gly?Asp?Arg?Val?Leu?Gly?Thr?Val?Pro?Gly
7085????????????????7090????????????????7095
Gly?Phe?Gly?Pro?Val?Val?Val?Ala?Asp?Gln?His?Tyr?Val?Thr?Gln
7100????????????????7105????????????????7110
Val?Pro?Glu?Gly?Trp?Thr?Met?Arg?Asp?Ala?Ala?Ser?Val?Pro?Leu
7115????????????????7120????????????????7125
Val?Phe?Leu?Thr?Ala?Leu?Tyr?Ala?Phe?Arg?Asp?Leu?Ala?Ser?Val
7130????????????????7135????????????????7140
Gln?Ala?Gly?Glu?Arg?Val?Leu?Ile?His?Ala?Gly?Ala?Gly?Gly?Val
7145????????????????7150????????????????7155
Gly?Met?Ala?Ala?Ile?Gln?Leu?Ala?Arg?His?Val?Gly?Ala?Glu?Val
7160????????????????7165????????????????7170
Phe?Ala?Thr?Ala?Ser?Glu?Pro?Lys?Trp?Glu?Thr?Leu?Arg?Ser?Leu
7175????????????????7180????????????????7185
Gly?Leu?Asp?Asp?Ala?His?Ile?Ala?Ser?Ser?Arg?Asp?Leu?Gly?Phe
7190????????????????7195????????????????7200
Glu?Glu?Lys?Phe?Arg?Glu?Val?Thr?Gly?Gly?Ala?Gly?Met?Asp?Val
7205????????????????7210????????????????7215
Val?Leu?Asn?Ala?Leu?Ala?Gly?Asp?Phe?Val?Asp?Ala?Ser?Leu?Arg
7220????????????????7225????????????????7230
Ile?Thr?Ala?Pro?Gly?Gly?Arg?Phe?Leu?Glu?Met?Gly?Lys?Thr?Asp
7235????????????????7240????????????????7245
Ile?Arg?Asp?Pro?Gln?Thr?Thr?Gly?Glu?Val?Arg?Tyr?Gln?Ala?Phe
7250????????????????7255????????????????7260
Asp?Leu?Gly?Glu?Ala?Gly?Pro?Glu?Arg?Asn?Lys?Ala?Leu?Leu?Gly
7265????????????????7270????????????????7275
Glu?Leu?Leu?Asp?Leu?Phe?Ala?Glu?Gly?Ala?Leu?Arg?Pro?Leu?Pro
7280????????????????7285????????????????7290
Val?Arg?Thr?Trp?Asp?Val?Arg?Arg?Ala?Arg?Glu?Ala?Phe?Arg?Phe
7295????????????????7300????????????????7305
Met?Ser?Gln?Ala?Lys?His?Thr?Gly?Lys?Ile?Val?Leu?Thr?Met?Pro
7310????????????????7315????????????????7320
Pro?Arg?Trp?Asn?Pro?Glu?Gly?Thr?Val?Leu?Ile?Thr?Gly?Gly?Thr
7325????????????????7330????????????????7335
Gly?Ala?Leu?Gly?Gly?His?Leu?Ala?Arg?Arg?Phe?Ala?Arg?Ala?Gly
7340????????????????7345????????????????7350
Met?Arg?His?Leu?Leu?Leu?Thr?Ser?Arg?Arg?Gly?Ala?Asp?Ala?Pro
7355????????????????7360????????????????7365
Gly?Ala?Ala?Glu?Leu?Ala?Ala?Glu?Leu?Arg?Glu?Leu?Gly?Ala?Glu
7370????????????????7375????????????????7380
Val?Thr?Val?Ala?Ala?Cys?Asp?Thr?Ala?Asp?Arg?Glu?Ala?Thr?Ala
7385????????????????7390????????????????7395
Ala?Leu?Leu?Asp?Ala?Val?Pro?Ala?Ala?His?Pro?Leu?Thr?Ala?Val
7400????????????????7405????????????????7410
Val?His?Thr?Ala?Gly?Ile?Leu?Asp?Asp?Gly?Val?Ile?Ala?Ser?Leu
7415????????????????7420????????????????7425
Thr?Pro?Glu?Arg?Leu?Ala?Ala?Val?Leu?Arg?Pro?Lys?Val?Asp?Ala
7430????????????????7435????????????????7440
Ala?Trp?His?Leu?His?Glu?Leu?Thr?Arg?Asp?Leu?Asp?Leu?Ala?Ala
7445????????????????7450????????????????7455
Phe?Leu?Pro?Phe?Ser?Ser?Val?Ala?Gly?Val?Met?Gly?Ser?Pro?Gly
7460????????????????7465????????????????7470
Gln?Gly?Asn?Tyr?Ala?Ala?Ala?Asn?Ser?Phe?Leu?Asp?Ala?Leu?Thr
7475????????????????7480????????????????7485
Arg?His?Arg?Arg?His?Leu?Gly?Leu?Ala?Gly?Thr?Ser?Leu?Ala?Trp
7490????????????????7495????????????????7500
Gly?Pro?Trp?Ala?His?Asp?Gly?Gly?Met?Thr?Ser?Thr?Leu?Ser?Asp
7505????????????????7510????????????????7515
Thr?Asp?Met?Arg?Arg?Met?Gln?Ser?Gly?Gly?Leu?Pro?Pro?Leu?Ala
7520????????????????7525????????????????7530
Val?Asp?Gln?Gly?Leu?Glu?Leu?Phe?Asp?Ile?Ala?Arg?Gly?Ser?Asp
7535????????????????7540????????????????7545
Glu?Ser?Phe?Leu?Val?Leu?Val?Gly?Leu?Ala?Ala?Gly?Ala?Met?Arg
7550????????????????7555????????????????7560
Gly?Ala?Ala?Pro?Glu?Asp?Leu?Pro?Pro?Leu?Phe?Arg?Ser?Met?Val
7565????????????????7570????????????????7575
Arg?Ser?Gly?Arg?Arg?Thr?Ala?Ala?Ser?Thr?Asp?Ala?Ala?Gly?Ala
7580????????????????7585????????????????7590
Ser?Ala?Ala?Leu?Gly?Ala?Lys?Leu?Ala?Gly?Leu?Gly?Ala?Ala?Glu
7595????????????????7600????????????????7605
Arg?Val?Arg?Tyr?Val?Thr?Asp?Leu?Val?Arg?Glu?Gln?Ala?Ala?Arg
7610????????????????7615????????????????7620
Val?Leu?Gly?His?Ala?Ser?Pro?Lys?Ser?Val?Asp?Val?Ser?Gln?Glu
7625????????????????7630????????????????7635
Phe?Arg?Glu?Leu?Gly?Val?Asp?Ser?Leu?Thr?Ala?Leu?Glu?Leu?Arg
7640????????????????7645????????????????7650
Asn?His?Leu?Ala?Thr?Ala?Thr?Gly?Leu?Arg?Leu?Pro?Ala?Thr?Leu
7655????????????????7660????????????????7665
Val?Phe?Asp?Tyr?Pro?Thr?Pro?Thr?Ala?Leu?Ala?Glu?His?Phe?Val
7670????????????????7675????????????????7680
Ala?Glu?Leu?Ala?Gly?Asp?Asp?Ala?Val?Pro?Gln?Gly?Pro?Ser?Leu
7685????????????????7690????????????????7695
Leu?Ala?Glu?Leu?Asp?Arg?Phe?Glu?Thr?Leu?Leu?Ser?Ala?Gly?Asp
7700????????????????7705????????????????7710
Pro?Asp?Glu?Ile?Thr?Arg?Ala?Gly?Leu?Ala?Leu?Arg?Leu?Gly?Gln
7715????????????????7720????????????????7725
Met?Leu?Asp?Gln?Val?Arg?Gly?Asn?Ala?Pro?Glu?Gln?Ala?Gly?Ser
7730????????????????7735????????????????7740
Ser?Leu?Asp?Asp?Asp?Phe?Glu?Ser?Ala?Ser?Thr?Asp?Glu?Val?Phe
7745????????????????7750????????????????7755
Ala?Phe?Ile?Asp?Asn?Glu?Leu?Gly?Arg?Leu?Gly?Asp?Leu
7760????????????????7765????????????????7770
<210>7
<211>9550
<212>PRT
＜213〉streptomycete FR-008
<400>7
Met?Gly?Cys?Val?Asp?Met?Asp?Lys?Glu?Gln?Lys?Leu?Arg?Asp?Tyr?Leu
l???????????????5???????????????????10??????????????????15
Lys?Arg?Ala?Ser?Ala?Asp?Leu?Lys?Arg?Ser?Arg?Gln?Arg?Val?Thr?Glu
20??????????????????25??????????????????30
Leu?Glu?Ala?Ala?Ala?Thr?Glu?Pro?Ile?Ala?Ile?Val?Gly?Met?Ser?Cys
35?????????????????40??????????????????45
Arg?Tyr?Pro?Gly?Gly?Val?Ser?Ser?Pro?Glu?Asp?Leu?Trp?Lys?Met?Leu
50??????????????????55??????????????????60
Val?Ala?Gly?Glu?Asp?Gly?lle?Thr?Gly?Met?Pro?Glu?Asp?Arg?Gly?Trp
65??????????????????70??????????????????75??????????????????80
Glu?Ala?Ala?Leu?Gly?Glu?Gly?Pro?Ala?Asp?Phe?Ala?Gly?Gly?Phe?Leu
85??????????????????90??????????????????95
His?Asp?Ala?Pro?Ala?Phe?Asp?Pro?Asp?Phe?Phe?Gly?Ile?Ser?Pro?Arg
100?????????????????105?????????????????110
Glu?Ala?Leu?Ser?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu?Thr?Gly
115?????????????????120?????????????????125
Trp?Glu?Ala?Phe?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Ala?Gly?Val?Arg?Gly
130?????????????????135?????????????????140
Ser?Arg?Thr?Gly?Met?Phe?Val?Gly?Ala?Met?Pro?Gln?Asp?Tyr?Arg?Val
145?????????????????150?????????????????155?????????????????160
Gly?Pro?Asp?Asp?Asp?Val?Gln?Gly?Phe?Gln?Leu?Thr?Gly?Asn?Ala?Thr
165?????????????????170?????????????????175
Ser?Ile?Leu?Ser?Gly?Arg?Leu?Ser?Tyr?Phe?Phe?Gly?Ala?Val?Gly?Pro
180?????????????????185?????????????????190
Ala?Val?Thr?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His
195?????????????????200?????????????????205
Leu?Ala?Ala?Gln?Ser?Leu?Arg?Ala?Gly?Glu?Cys?Ser?Leu?Ala?Leu?Ala
210?????????????????215?????????????????220
Ala?Gly?Val?Thr?Val?Met?Ala?Ser?Pro?Thr?Thr?Phe?Val?Glu?Phe?Ala
225?????????????????230?????????????????235?????????????????240
Arg?Gln?Gly?Gly?Leu?Ala?Ala?Asp?Gly?Arg?Cys?Arg?Ser?Phe?Ala?Asp
245?????????????????250?????????????????255
Ala?Ala?Asn?Gly?Thr?Gly?Trp?Ser?Glu?Gly?Val?Gly?Val?Leu?Val?Leu
260?????????????????265?????????????????270
Glu?Arg?Leu?Ser?Glu?Ala?Arg?Arg?Asn?Gly?His?Arg?Val?Leu?Ala?Val
275?????????????????280?????????????????285
Val?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr
290?????????????????295?????????????????300
Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val?Ile?Glu?Ser?Ala?Leu?Val
305?????????????????310?????????????????315?????????????????320
Asn?Ala?Arg?Leu?Thr?Ala?Ala?Asp?Val?Asp?Ala?Val?Glu?Ala?His?Gly
325?????????????????330?????????????????335
Thr?Gly?Thr?Val?Leu?Gly?Asp?Pro?Val?Glu?Ala?Gln?Ala?Leu?Leu?Ala
340?????????????????345?????????????????350
Thr?Tyr?Gly?Gln?Gly?Arg?Glu?Ala?Asp?Ser?Pro?Leu?Leu?Leu?Gly?Ser
355?????????????????360?????????????????365
Val?Lys?Ser?Asn?Ile?Ser?His?Thr?Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly
370?????????????????375?????????????????380
Val?Ile?Lys?Met?Val?Met?Ala?Met?Arg?His?Gly?Leu?Leu?Pro?Arg?Thr
385?????????????????390?????????????????395?????????????????400
Leu?His?Val?Asp?Gln?Pro?Ser?Thr?His?Val?Asp?Trp?Ser?Glu?Gly?Ser
405?????????????????410?????????????????415
eu?Leu?Thr?Glu?Pro?Ala?Pro?Trp?Pro?Ala?Arg?Glu?Asn?Ala
420?????????????????425?????????????????430
Pro?Arg?Arg?Ala?Gly?Ile?Ser?Ser?Phe?Gly?Leu?Ser?Gly?Thr?Asn?Ala
435?????????????????440?????????????????445
His?Thr?Ile?Ile?Glu?Glu?Ala?Pro?Gln?Glu?Pro?Ala?Ala?Asp?Gly?Glu
450?????????????????455?????????????????460
Ala?Ala?Pro?Ala?Val?Asp?Ala?Gly?Ala?Leu?Pro?Trp?Leu?Leu?Ser?Gly
465?????????????????470?????????????????475?????????????????480
Arg?Thr?Pro?Glu?Ala?Leu?Arg?Ala?Gln?Ala?Ala?Arg?Leu?Leu?Asp?His
485?????????????????490?????????????????495
Leu?Ala?Ala?Arg?Pro?Thr?Pro?Ser?Ala?Leu?Asp?Val?Ser?His?Ala?Leu
500?????????????????505?????????????????510
Ala?Thr?Thr?Arg?Ser?Ala?Leu?Glu?His?Arg?Ala?Ala?Phe?Thr?Thr?Ala
515?????????????????520?????????????????525
Asp?Arg?Asp?Thr?Ala?Val?Ala?Val?Leu?Thr?Ala?Leu?Ala?Ala?Gly?Ala
530?????????????????535?????????????????540
Asp?Ala?Pro?Gly?Leu?Thr?Thr?His?Gln?Leu?Arg?Gly?Arg?Thr?Lys?Leu
545?????????????????550?????????????????555?????????????????560
Ala?Val?Leu?Phe?Ser?Gly?Gln?Gly?Ser?Gln?Arg?Pro?Gly?Met?Gly?Arg
565?????????????????570?????????????????575
Asp?Leu?His?Ala?Arg?Phe?Pro?Val?Phe?Ala?Arg?Ala?Leu?Asp?Glu?Ile
580?????????????????585?????????????????590
Leu?Glu?His?Leu?Asp?Ala?Gly?Leu?Asp?Arg?Pro?Leu?Lys?Pro?Leu?Ile
595?????????????????600?????????????????605
Leu?Ala?Glu?Glu?Gly?Ser?Glu?Glu?Ala?Ala?Leu?Leu?Asp?Arg?Thr?Glu
610?????????????????615?????????????????620
Tyr?Ala?Gln?Pro?Ala?Leu?Phe?Ala?Leu?Glu?Val?Ala?Leu?Tyr?Arg?Leu
625?????????????????630?????????????????635?????????????????640
Val?Glu?Ser?Trp?Gly?Val?Thr?Pro?Asp?His?Leu?Thr?Gly?His?Ser?Val
645?????????????????650?????????????????655
Gly?Glu?Ile?Ala?Ala?Ala?His?Val?Ala?Gly?Val?Phe?Thr?Leu?Ala?Asp
660?????????????????665?????????????????670
Ala?Cys?Thr?Leu?Val?Thr?Ala?Arg?Gly?Arg?Leu?Met?Gln?Ala?Leu?Asp
675?????????????????680?????????????????685
Glu?Gly?Gly?Ala?Met?Val?Ser?Leu?Glu?Ala?Thr?Glu?Asp?Glu?Val?Ala
690?????????????????695?????????????????700
Pro?Leu?Val?Ala?Glu?His?Ala?Gly?Gln?Val?Ser?Val?Ala?Ala?Val?Asn
705?????????????????710?????????????????715?????????????????720
Gly?Pro?Ala?Ala?Val?Val?Val?Ser?Gly?Ala?Glu?Asp?Ala?Val?Glu?Ser
725?????????????????730?????????????????735
Ile?Ala?Ala?Arg?Val?Ala?Ala?Leu?Gly?Arg?Arg?Thr?Arg?Arg?Leu?Arg
740?????????????????745?????????????????750
Val?Ser?His?Ala?Phe?His?Ser?Pro?Leu?Met?Asp?Pro?Met?Leu?Glu?Glu
755?????????????????760?????????????????765
Phe?Arg?Ala?Val?Val?Ala?Gly?Leu?Ser?Pro?Gln?Ala?Pro?Thr?Val?Pro
770?????????????????775?????????????????780
Val?Val?Ser?Asn?Leu?Thr?Gly?Ala?Pro?Ala?Thr?Val?Glu?Gln?Leu?Thr
785?????????????????790?????????????????795?????????????????800
Ser?Ala?Gly?Tyr?Trp?Thr?Asp?His?Val?Arg?His?Ala?Val?Arg?Phe?Ala
805?????????????????810?????????????????815
Asp?Gly?Val?Ser?Trp?Leu?Ala?Gly?His?Gly?Thr?Gly?Leu?Phe?Leu?Glu
820?????????????????825?????????????????830
Leu?Gly?Pro?Asp?Ala?Thr?Leu?Ala?Ala?Leu?Thr?Arg?Thr?Val?Leu?Asp
835?????????????????840?????????????????845
Ala?Ala?Gly?His?Glu?Arg?Ala?Ala?Val?Leu?Pro?Ala?Leu?Arg?Lys?Asp
850?????????????????855?????????????????860
Arg?Pro?Glu?Ala?Ala?Thr?Leu?Thr?Glu?Thr?Ala?Thr?Gly?Leu?His?Leu
865?????????????????870?????????????????875?????????????????880
Arg?Gly?Val?Pro?Val?Arg?Trp?Asp?Arg?Trp?Phe?Glu?Gly?Thr?Gly?Ala
885?????????????????890?????????????????895
Gly?His?Thr?Asp?Leu?Pro?Thr?Tyr?Ala?Phe?Gln?His?Arg?Arg?Phe?Trp
900?????????????????905?????????????????910
Pro?Lys?Gly?Val?Thr?Gly?Leu?Thr?Gly?Asp?Met?Arg?Ser?Ala?Gly?Leu
915?????????????????920?????????????????925
Gly?Ala?Ala?His?His?Pro?Leu?Leu?Ala?Ala?Ala?Val?Thr?Leu?Ala?Asn
930?????????????????935?????????????????940
Ser?Asp?Gly?Leu?Leu?Leu?Thr?Gly?Arg?Leu?Ser?Val?Arg?Thr?His?Pro
945?????????????????950?????????????????955?????????????????960
Trp?Leu?Ala?Asp?His?Thr?Val?Arg?Gly?Thr?Val?Leu?Leu?Ala?Gly?Thr
965?????????????????970?????????????????975
Ala?Phe?Leu?Glu?Leu?Ala?Val?Arg?Ala?Gly?Asp?Glu?Val?Gly?Cys?Asp
980?????????????????985?????????????????990
Arg?Val?Glu?Glu?Leu?Thr?Leu?Ala?Ala?Pro?Leu?Ala?Leu?Pro?Glu?Asp
995?????????????????1000????????????????1005
Gly?Gly?Val?Gln?Val?Gln?Val?Trp?Ile?Gly?Ser?Pro?Asp?Glu?Thr
1010????????????????1015????????????????1020
Gly?Arg?Arg?Ala?Leu?Thr?Leu?Tyr?Ser?Arg?Pro?Asp?Gly?Asp?Asp
1025????????????????1030????????????????1035
Asp?Arg?Pro?Trp?Thr?Gln?His?Ala?Ala?Gly?Thr?Leu?Thr?Asn?Gly
1040????????????????1045????????????????1050
Ala?His?His?Gly?Glu?Glu?Phe?Asp?Ala?Ala?Val?Trp?Pro?Pro?Ala
1055????????????????1060????????????????1065
Gly?Ala?Glu?Ser?Val?Gly?Leu?Asp?Gly?Phe?Tyr?Glu?Gly?Leu?Ala
1070????????????????1075????????????????1080
Glu?Ser?Gly?Phe?Ala?Tyr?Gly?Pro?Ala?Phe?Arg?Gly?Leu?Arg?Ala
1085????????????????1090????????????????1095
Val?Trp?Arg?Arg?Gly?Glu?Glu?Thr?Phe?Ala?Glu?Val?Ala?Leu?Asp
1100????????????????1105????????????????1110
Ala?Gly?Pro?Ala?Gly?Asp?Ala?Ser?Ser?Phe?Gly?Leu?His?Pro?Ala
1115????????????????1120????????????????1125
Leu?Leu?Asp?Ala?Ala?Leu?His?Ala?Thr?Ala?Leu?Ala?Pro?Leu?Gly
1130????????????????1135????????????????1140
Glu?Asp?Ala?Arg?Gly?Gly?Leu?Pro?Phe?Ala?Trp?Gln?Asp?Val?Thr
1145????????????????1150????????????????1155
Leu?His?Ala?Ala?Gly?Ala?Thr?Glu?Ala?Arg?Val?Arg?Ile?Thr?Pro
1160????????????????1165????????????????1170
Ala?Gly?Asp?Asp?Ala?Val?Thr?Leu?Thr?Val?Ala?Asp?Thr?Thr?Gly
1175????????????????1180????????????????1185
Ala?Pro?Val?Ala?Ser?Val?Gly?Ser?Leu?Val?Leu?Arg?Ser?Ala?Pro
1190????????????????1195????????????????1200
Asp?Ala?Arg?Arg?Ala?Ala?Ala?Gly?Val?Leu?Glu?Arg?Asp?Ala?Leu
1205????????????????1210????????????????1215
Phe?His?Leu?Asp?Trp?Thr?Arg?Leu?His?Gly?Ala?Asp?Ala?Pro?Glu
1220????????????????1225????????????????1230
Thr?Pro?Gly?Thr?Val?Gly?Leu?Leu?Gly?Pro?Asp?Pro?Leu?Arg?Leu
1235????????????????1240????????????????1245
Gly?Ala?Ala?Leu?Thr?Ala?Ala?Gly?Val?Thr?Val?Gly?Pro?Leu?Thr
1250????????????????1255????????????????1260
Glu?Ala?Ala?Gly?Pro?Asp?Thr?Pro?Ala?Leu?Val?Leu?Val?Pro?Val
1265????????????????1270????????????????1275
Gly?Gly?Gly?Asp?Pro?Glu?Ala?Val?Pro?Ala?Glu?Val?His?Ala?Ser
1280????????????????1285????????????????1290
Thr?Ala?Arg?Val?Leu?Gly?His?Ile?Gln?Arg?Trp?Leu?Ala?Glu?Asp
1295????????????????1300????????????????1305
Thr?Arg?Ala?Gly?Ala?Arg?Leu?Val?Phe?Val?Thr?Arg?Gly?Ala?Val
1310????????????????1315????????????????1320
Ala?Val?Gly?Glu?Gly?Pro?Leu?Thr?Asp?Pro?Ala?Ala?Ala?Ala?Val
1325????????????????1330????????????????1335
Trp?Gly?Leu?Val?Arg?Ser?Ala?Gln?Ala?Glu?His?Pro?His?Arg?Phe
1340????????????????1345????????????????1350
Gly?Leu?Leu?Asp?Leu?Asp?Pro?Val?Ala?Gly?Thr?Asp?Pro?Ala?Ala
1355????????????????1360????????????????1365
Leu?Val?Ala?Ala?Leu?Ala?Ala?Glu?Glu?Pro?Gln?Thr?Ala?Leu?Arg
1370????????????????1375????????????????1380
Gly?Asp?Thr?Val?Phe?Ala?Ala?Arg?Leu?Ala?Arg?Val?Arg?Pro?Asp
1385????????????????1390????????????????1395
Gly?Glu?Thr?Thr?Ala?Ala?Ala?Trp?Asn?Pro?Glu?Gly?Thr?Val?Val
1400????????????????1405????????????????1410
Val?Thr?Gly?Gly?Thr?Gly?Gly?Leu?Gly?Ala?Ala?Leu?Ala?Arg?His
1415????????????????1420????????????????1425
Leu?Val?Thr?Glu?Arg?Gly?Val?Arg?His?Leu?Val?Leu?Ala?Gly?Arg
1430????????????????1435????????????????1440
Arg?Gly?Pro?Asp?Ala?Pro?Gly?Ala?Ala?Gly?Leu?Ala?Ala?Asp?Leu
1445????????????????1450????????????????1455
Gly?Ala?Leu?Gly?Ala?Glu?Val?Thr?Leu?Ala?Ala?Cys?Asp?Val?Ala
1460????????????????1465????????????????1470
Asp?Pro?Glu?Ala?Val?Asp?Arg?Leu?Phe?Ala?Ala?Val?Pro?Ala?Ala
1475????????????????1480????????????????1485
His?Pro?Val?Thr?Ala?Val?Val?His?Thr?Ala?Gly?Thr?Leu?Asp?Asp
1490????????????????1495????????????????1500
Gly?Leu?Val?Glu?Ser?Leu?Thr?Glu?Glu?Arg?Leu?Ala?Ala?Val?Leu
1505????????????????1510????????????????1515
Arg?Pro?Lys?Ala?Asp?Ala?Val?Trp?His?Leu?His?Arg?Ala?Thr?Arg
1520????????????????1525????????????????1530
Asp?Leu?Asp?Leu?Ala?Ala?Phe?Val?Val?Phe?Ser?Ser?Leu?Ala?Gly
1535????????????????1540????????????????1545
Thr?Thr?Gly?Ala?Pro?Gly?Gln?Ala?Asn?Tyr?Ala?Ala?Gly?Asn?Ala
1550????????????????1555????????????????1560
Phe?Leu?Asp?Ala?Val?Ala?Arg?Leu?Arg?Arg?Asp?Ala?Gly?Leu?Pro
1565????????????????1570????????????????1575
Gly?Leu?Ser?Leu?Gly?Trp?Gly?Pro?Trp?Val?Pro?Val?Asp?Gly?Gly
1580????????????????1585????????????????1590
Met?Thr?Gly?Glu?Leu?Ser?Glu?Arg?Asp?Leu?Glu?Arg?Met?Ser?Arg
1595????????????????1600????????????????1605
Ser?Gly?Thr?Pro?Pro?Leu?Thr?Val?Glu?Gln?Gly?Leu?Ala?Leu?Phe
1610????????????????1615????????????????1620
Asp?Ala?Thr?Leu?Ala?Leu?Pro?Arg?Ala?Ala?Val?Leu?Pro?Val?Arg
1625????????????????1630????????????????1635
Leu?Asp?Leu?Ala?Ala?Leu?Arg?Gly?Arg?Gly?Glu?Val?Pro?Pro?Leu
1640????????????????1645????????????????1650
Leu?Arg?Gly?Leu?Val?Arg?Thr?Arg?Ala?Arg?Arg?Thr?Val?Arg?Thr
1655????????????????1660????????????????1665
Gly?Ser?Glu?Ala?Ala?Leu?Gly?Leu?Ala?Gln?Arg?Leu?Ala?Arg?Leu
1670????????????????1675????????????????1680
Asp?Glu?Gln?Ala?Arg?Thr?Glu?Ala?Val?Val?Asp?Leu?Val?Arg?Asp
1685????????????????1690????????????????1695
Arg?Thr?Ala?Ala?Val?Leu?Gly?His?Ala?Ser?Ala?Ala?Asp?Ile?Asp
1700????????????????1705????????????????1710
Pro?Glu?Arg?Pro?Phe?Gln?Glu?Leu?Gly?Phe?Asp?Ser?Leu?Thr?Ala
1715????????????????1720????????????????1725
Val?Glu?Leu?Arg?Asn?Gly?Leu?Ala?Ala?Ala?Thr?Gly?Leu?Arg?Thr
1730????????????????1735????????????????1740
Ser?Ala?Thr?Val?Ile?Phe?Asp?Tyr?Pro?Thr?Val?Ala?Ala?Leu?Ala
1745????????????????1750????????????????1755
Gly?His?Leu?Leu?Ala?Glu?Leu?Thr?Asp?Ala?Pro?Glu?Ala?Glu?Ala
1760????????????????1765????????????????1770
Pro?Ala?Pro?Ala?Pro?Arg?Thr?Ser?Ala?Thr?Ala?Asp?Asp?Pro?Ile
1775????????????????1780????????????????1785
Val?Ile?Val?Gly?Met?Ser?Cys?Arg?Tyr?Pro?Gly?Gly?Val?Gly?Ser
1790????????????????1795????????????????1800
Pro?Asp?Asp?Leu?Trp?Arg?Leu?Val?Thr?Glu?Gly?Thr?Asp?Ala?Ile
1805????????????????1810????????????????1815
Gly?Gly?Leu?Pro?Val?Asn?Arg?Gly?Trp?Asp?Leu?Asp?Ser?Leu?Tyr
1820????????????????1825????????????????1830
His?Pro?Asp?Pro?Asp?His?Pro?Gly?Thr?Ser?Tyr?Thr?Arg?Tyr?Gly
1835????????????????1840????????????????1845
Gly?Phe?Leu?His?Asp?Ala?Gly?Glu?Phe?Asp?Ala?Gly?Phe?Phe?Gly
1850????????????????1855????????????????1860
Met?Ser?Pro?Arg?Glu?Ala?Leu?Ala?Thr?Asp?Ser?Gln?Gln?Arg?Leu
1865????????????????1870????????????????1875
Leu?Leu?Glu?Ala?Ser?Trp?Thr?Ala?Val?Glu?His?Ala?Gly?Ile?Asp
1880????????????????1885????????????????1890
Pro?Val?Gly?Leu?Arg?Gly?Ser?Arg?Thr?Gly?Val?Phe?Ala?Gly?Val
1895????????????????1900????????????????1905
Met?Tyr?Ser?Asp?Tyr?Ser?Ala?Thr?Leu?Ala?Asp?Glu?Arg?Phe?Glu
1910????????????????1915????????????????1920
Gly?His?Gln?Gly?Ser?Gly?Thr?Ala?Pro?Ser?Ile?Ala?Ser?Gly?Arg
1925????????????????1930????????????????1935
Val?Ser?Tyr?Ala?Leu?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp
1940????????????????1945????????????????1950
Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val?Ala?Met?His?Trp?Ala?Met?Gln
1955????????????????1960????????????????1965
Ala?Leu?Arg?Ser?Gly?Glu?Cys?Ser?Leu?Ala?Leu?Ala?Gly?Gly?Val
1970????????????????1975????????????????1980
Thr?Val?Met?Ser?Thr?Pro?Thr?Ser?Leu?Ile?Glu?Phe?Ser?Arg?Gln
1985????????????????1990????????????????1995
Arg?Gly?Leu?Ser?Pro?Asp?Gly?Arg?Cys?Lys?Ala?Phe?Ser?Asp?Glu
2000????????????????2005????????????????2010
Ala?Asp?Gly?Val?Gly?Trp?Ser?Glu?Gly?Val?Gly?Met?Leu?Val?Leu
2015????????????????2020????????????????2025
Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Arg?Val?Leu?Ala
2030????????????????2035????????????????2040
Val?Val?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly
2045????????????????2050????????????????2055
Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val?Ile?Arg?Gln
2060????????????????2065????????????????2070
Ala?Leu?Asp?Thr?Ala?Gly?Leu?Thr?Thr?Ala?Asp?Val?Asp?Ala?Val
2075????????????????2080????????????????2085
Glu?Ala?His?Gly?Thr?Gly?Thr?Ala?Leu?Gly?Asp?Pro?Ile?Glu?Ala
2090????????????????2095????????????????2100
Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Asp?Arg?Pro?Gly?Asp?Arg
2105????????????????2110????????????????2115
Pro?Leu?Leu?Leu?Gly?Ser?Val?Lys?Ser?Asn?Ile?Gly?His?Thr?Gln
2120????????????????2125????????????????2130
Ala?Ala?Ala?Gly?Val?Ala?Gly?Ile?Ile?Lys?Met?Val?Met?Ala?Met
2135????????????????2140????????????????2145
Arg?His?Gly?Glu?Leu?Pro?Arg?Thr?Leu?His?Ala?Gly?Ser?Pro?Ser
2150????????????????2155????????????????2160
Arg?His?Val?Asp?Trp?Glu?Thr?Gly?Asp?Val?Arg?Ile?Leu?Gln?Glu
2165????????????????2170????????????????2175
Pro?Glu?Ala?Trp?Pro?Glu?Thr?Gly?Arg?Pro?Arg?Arg?Ala?Gly?Val
2180????????????????2185????????????????2190
Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr?Asn?Ala?His?Val?Val?Leu?Glu
2195????????????????2200????????????????2205
Gln?Gly?Glu?Ser?Ala?Pro?Ala?Gly?Ser?Thr?Gly?Thr?Pro?Pro?Ala
2210????????????????2215????????????????2220
Glu?Ala?Thr?Val?Leu?Pro?Trp?Thr?Leu?Ser?Gly?Arg?Thr?Arg?Pro
2225????????????????2230????????????????2235
Ala?Leu?Arg?Ala?Gln?Ala?Ala?Arg?Leu?Leu?Ala?His?Leu?Asp?Ala
2240????????????????2245????????????????2250
Arg?Pro?Asp?Glu?Ala?Pro?Ala?Asp?Leu?Thr?His?Ser?Leu?Ala?Thr
2255????????????????2260????????????????2265
Thr?Arg?Pro?Ala?Phe?Glu?Gln?Arg?Ala?Val?Val?Val?Gly?Thr?Ala
2270????????????????2275????????????????2280
Asp?Asp?Ala?Arg?Arg?Ala?Leu?Ala?Ala?Leu?Ala?Ala?Asp?Arg?Pro
2285????????????????2290????????????????2295
Asp?Pro?Ala?Leu?Val?Leu?Gly?Glu?Thr?Gly?Gly?Thr?Gly?Arg?Thr
2300????????????????2305????????????????2310
Ala?Leu?Leu?Phe?Thr?Gly?Gln?Gly?Ser?Gln?Arg?Pro?Gly?Thr?Gly
2315????????????????2320????????????????2325
Arg?Glu?Leu?Tyr?Glu?Arg?His?Pro?Val?Phe?Ala?Glu?Ala?Leu?Asp
2330????????????????2335????????????????2340
Glu?Val?Val?Ala?Arg?Leu?Asp?Pro?Leu?Leu?Val?Asp?Ala?Pro?Ala
2345????????????????2350????????????????2355
Gly?Thr?Pro?His?Gly?Ser?Leu?Lys?Asp?Val?Met?Phe?Ala?Glu?Glu
2360????????????????2365????????????????2370
Gly?Thr?Pro?Gly?Ala?Ala?Ala?Leu?Tyr?Glu?Thr?Gly?Trp?Thr?Gln
2375????????????????2380????????????????2385
Pro?Ala?Leu?Phe?Ala?Leu?Glu?Thr?Ala?Leu?Tyr?Arg?Leu?Val?Arg
2390????????????????2395????????????????2400
Ser?Trp?Gly?Val?Arg?Pro?Gly?Val?Leu?Leu?Gly?His?Ser?Val?Gly
2405????????????????2410????????????????2415
Gly?Ile?Gly?Ala?Ala?His?Ala?Ala?Gly?Val?Leu?Ser?Leu?Asp?Asp
2420????????????????2425????????????????2430
Ala?Cys?Ala?Leu?Val?Ala?Ala?Arg?Ala?Arg?Leu?Met?Gln?Ala?Leu
2435????????????????2440????????????????2445
Pro?Glu?Gly?Gly?Ala?Met?Trp?Ser?Leu?Gln?Ala?Ser?Glu?Asp?Glu
2450????????????????2455????????????????2460
Val?Leu?Pro?Leu?Leu?Gln?Gly?Gln?Glu?Asp?Val?Ala?Ala?Leu?Ala
2465????????????????2470????????????????2475
Ala?Val?Asn?Gly?Pro?Ser?Ala?Val?Val?Val?Ser?Gly?Glu?Glu?Glu
2480????????????????2485????????????????2490
Ala?Thr?Ala?Ala?Ile?Ala?Ala?His?Phe?Ala?Gly?Leu?Gly?Arg?Ala
2495????????????????2500????????????????2505
Thr?Arg?Arg?Leu?Arg?Val?Ser?His?Ala?Phe?His?Ser?Pro?Arg?Met
2510????????????????2515????????????????2520
Asp?Ala?Val?Leu?Asp?Ala?Phe?Arg?Glu?Val?Ala?Glu?Gly?Leu?Thr
2525????????????????2530????????????????2535
Tyr?His?Glu?Pro?Thr?Val?Pro?Val?Ala?Cys?Asp?Leu?Thr?Gly?Arg
2540????????????????2545????????????????2550
Leu?Ala?Glu?Gly?Asp?His?Leu?Arg?Thr?Ala?Asp?Tyr?Trp?Val?Arg
2555????????????????2560????????????????2565
His?Val?Arg?Ser?Thr?Val?Arg?Phe?Ala?Asp?Ala?Val?Arg?Ala?Ala
2570????????????????2575????????????????2580
His?Glu?Ala?Gly?Ala?Thr?Thr?Tyr?Leu?Glu?Leu?Gly?Pro?Gly?Gly
2585????????????????2590????????????????2595
Ser?Leu?Cys?Ala?Ala?Ala?Gln?Asp?Thr?Leu?Gly?Asp?Asp?Ser?Glu
2600????????????????2605????????????????2610
Ala?Asp?Ala?Val?Pro?Thr?Leu?Arg?Thr?Gly?Arg?Pro?Glu?Asp?Glu
2615????????????????2620????????????????2625
Ser?Val?Leu?Thr?Ala?Leu?Ala?Arg?Leu?His?Val?Arg?Gly?Val?Arg
2630????????????????2635????????????????2640
Val?Asp?Trp?Gly?Ala?Val?His?Pro?Ala?Gly?Ala?Gly?Thr?Val?Glu
2645????????????????2650????????????????2655
Leu?Pro?Thr?Tyr?Ala?Phe?Gln?His?Glu?Thr?Tyr?Trp?Pro?Asp?Thr
2660????????????????2665????????????????2670
Thr?Ala?Pro?Thr?Val?Arg?Arg?Thr?Gly?Asp?Gly?Ser?Gly?Asp?Pro
2675????????????????2680????????????????2685
Ala?Asp?Ala?Glu?Leu?Trp?Thr?Ala?Val?Glu?Arg?Gly?Asp?Ala?Thr
2690????????????????2695????????????????2700
Gly?Leu?Ala?Gly?Leu?Leu?Gly?Leu?Arg?Asp?Glu?Glu?His?Ala?Ser
2705????????????????2710????????????????2715
Leu?Tyr?Thr?Leu?Leu?Pro?Ser?Leu?Ser?Ser?Trp?Arg?Arg?Ala?Arg
2720????????????????2725????????????????2730
Gln?Glu?Arg?Ala?Val?Leu?Asp?Ala?Ala?Arg?Tyr?Arg?Ile?Ala?Trp
2735????????????????2740????????????????2745
Gln?Pro?Ala?Gly?Thr?Glu?Ser?Ala?Pro?Val?Leu?Asp?Gly?Thr?Trp
2750????????????????2755????????????????2760
Leu?Ala?Val?Thr?Thr?Glu?Asp?Asp?Gly?Ala?Ala?Asp?Thr?Val?Leu
2765????????????????2770????????????????2775
Ala?Ala?Leu?Arg?Gly?His?Gly?Ala?Val?Val?Glu?Arg?Leu?Val?Leu
2780????????????????2785????????????????2790
Asp?Ala?Ser?His?Leu?Asp?Arg?Asp?Leu?Leu?Thr?Thr?Thr?Leu?Arg
2795????????????????2800????????????????2805
Asp?Ala?Val?Glu?Asn?Ala?Thr?Ala?Glu?Gly?Ala?Ala?Gly?Val?Arg
2810????????????????2815????????????????2820
Gly?Ile?Leu?Ser?Leu?Leu?Pro?Leu?Ala?Asp?Ala?Ala?Arg?Pro?Glu
2825????????????????2830????????????????2835
Ala?Thr?Gly?Thr?Asp?Ala?Pro?Ala?Gly?Gly?Leu?Pro?Ala?Gly?Phe
2840????????????????2845????????????????2850
Ala?Leu?Gly?Val?Val?Leu?Ala?Gln?Ala?Leu?Gly?Asp?Ala?Ala?Val
2855????????????????2860????????????????2865
Thr?Ala?Pro?Leu?Trp?Thr?Val?Thr?Arg?Gly?Ala?Val?Ser?Thr?Gly
2870????????????????2875????????????????2880
Pro?Gly?Asp?Pro?Leu?Thr?His?Pro?Ala?Arg?Ala?Ala?Ala?Trp?Gly
2885????????????????2890????????????????2895
Leu?Gly?Arg?Val?Ala?Ala?Leu?Glu?Arg?Pro?Glu?Gln?Trp?Ser?Gly
2900????????????????2905????????????????2910
Leu?Val?Asp?Leu?Pro?Glu?Val?Leu?Asp?Ala?Pro?Ala?Thr?Gln?Arg
2915????????????????2920????????????????2925
Leu?Val?Ser?Leu?Leu?Ala?Thr?Arg?Asp?Gly?Glu?Asp?Gln?Leu?Ala
2930????????????????2935????????????????2940
Val?Arg?Ala?Gly?Gly?Thr?Leu?Ala?Arg?Arg?Val?Val?Arg?His?Pro
2945????????????????2950????????????????2955
Gly?Asp?Ala?Leu?Pro?Arg?Glu?Asp?Glu?Phe?Thr?Ala?Ser?Gly?Thr
2960????????????????2965????????????????2970
Val?Leu?Val?Thr?Gly?Gly?Thr?Gly?Gly?Leu?Gly?Ala?Glu?Ala?Ala
2975????????????????2980????????????????2985
Arg?Trp?Leu?Ala?Arg?Ser?Gly?Ala?Ala?His?Leu?Val?Leu?Thr?Gly
2990????????????????2995????????????????3000
Arg?Arg?Gly?Pro?Asp?Ala?Pro?Gly?Ala?Ala?Glu?Leu?Arg?Ala?Glu
3005????????????????3010????????????????3015
Leu?Glu?Glu?Leu?Gly?Ala?Arg?Val?Thr?Leu?Thr?Ala?Cys?Asp?Ser
3020????????????????3025????????????????3030
Ala?Asp?Arg?Asp?Ala?Leu?Ala?Ala?Val?Leu?Ala?Ala?Val?Pro?Glu
3035????????????????3040????????????????3045
Asp?Ala?Pro?Leu?Thr?Gly?Val?Val?His?Ala?Ala?Gly?Val?Gly?Gln
3050????????????????3055????????????????3060
Ala?Ala?Pro?Leu?Ala?Asp?Thr?Pro?Leu?Asp?Gln?Val?Ala?Ala?Ala
3065????????????????3070????????????????3075
Met?Ala?Ala?Lys?Thr?Leu?Gly?Ala?Ala?His?Leu?Asp?Ala?Leu?Leu
3080????????????????3085????????????????3090
Asp?Gly?His?Asp?Leu?Asp?Phe?Leu?Val?Leu?Val?Ser?Ser?Val?Ala
3095????????????????3100????????????????3105
Gly?Val?Trp?Gly?Ser?Ala?Gly?Gln?Ser?Ala?Tyr?Ala?Ala?Ala?Asn
3110????????????????3115????????????????3120
Ala?Tyr?Leu?Asp?Ala?Leu?Ala?Glu?Asn?Arg?Arg?Ser?Arg?Gly?Leu
3125????????????????3130????????????????3135
Ala?Ala?Thr?Ser?Val?Ala?Trp?Gly?Pro?Trp?Ala?Glu?Val?Gly?Met
3140????????????????3145????????????????3150
Ala?Ser?Ala?His?Arg?Thr?Val?Ser?Glu?Asn?Leu?Glu?Arg?Ala?Gly
3155????????????????3160????????????????3165
Leu?Arg?Leu?Leu?Asn?Pro?Ala?Thr?Ala?Met?Thr?Glu?Leu?Arg?Arg
3170????????????????3175????????????????3180
Ala?Val?Val?Arg?Gly?Glu?Thr?Thr?Val?Thr?Val?Ala?Asp?Val?Asp
3185????????????????3190????????????????3195
Trp?Glu?Gln?Tyr?His?Pro?Val?Phe?Thr?Ala?Ala?Arg?Ser?Ser?Arg
3200????????????????3205????????????????3210
Leu?Phe?Asp?Thr?Val?Asp?Thr?Val?Ala?Ala?Leu?Ala?Ala?Pro?Gly
3215????????????????3220????????????????3225
Ser?Thr?Gly?Thr?Val?Ser?Gly?Leu?Ala?Glu?Arg?Leu?Gly?Gly?Leu
3230????????????????3235????????????????3240
Thr?Glu?Gln?Glu?Gln?Glu?Arg?Leu?Leu?Val?Asp?Leu?Val?Arg?Ala
3245????????????????3250????????????????3255
Glu?Ala?Ala?Val?Val?Leu?Gly?His?Thr?Ser?Ala?Glu?Gly?Val?Pro
3260????????????????3265????????????????3270
Val?Lys?Lys?Ala?Phe?Arg?Asp?Ala?Gly?Phe?Asp?Ser?Leu?Thr?Ala
3275????????????????3280????????????????3285
Val?Glu?Leu?Arg?Lys?Arg?Leu?Ala?His?Leu?Thr?Gly?Leu?Ala?Leu
3290????????????????3295????????????????3300
Pro?Ser?Thr?Leu?Val?Phe?Asp?Tyr?Pro?Asn?Pro?Leu?Ala?Leu?Ala
3305????????????????3310????????????????3315
Arg?His?Leu?Arg?Ala?Glu?Leu?Leu?Gly?Thr?Val?Glu?Thr?Ala?Pro
3320????????????????3325????????????????3330
Val?Ala?Thr?Gly?Pro?Ala?Val?Thr?Asp?Glu?Pro?Ile?Ala?Ile?Ile
3335????????????????3340????????????????3345
Gly?Met?Ser?Cys?Arg?Phe?Pro?Gly?Gly?Ala?Arg?Ser?Ala?Asp?Ala
3350????????????????3355????????????????3360
Phe?Trp?Gln?Leu?Val?Ala?Asp?Asn?Thr?Asp?Ala?Ile?Ser?Glu?Phe
3365????????????????3370????????????????3375
Pro?Val?Asn?Arg?Gly?Trp?Asp?Gly?Asp?Ala?Leu?Tyr?Asp?Pro?Asp
3380????????????????3385????????????????3390
Pro?Asp?Arg?Pro?Gly?Thr?Thr?Tyr?Ser?Thr?Gln?Gly?Gly?Phe?Leu
3395????????????????3400????????????????3405
His?Asp?Ala?Gly?Glu?Phe?Asp?Ala?Gly?Phe?Phe?Gly?Ile?Ser?Pro
3410????????????????3415????????????????3420
Arg?Glu?Ala?Val?Ser?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu
3425????????????????3430????????????????3435
Thr?Thr?Trp?Glu?Ala?Phe?Glu?His?Ala?Gly?Ile?Asp?Pro?Ala?Ala
3440????????????????3445????????????????3450
Val?His?Ser?Thr?Pro?Thr?Gly?Thr?Phe?Ile?Gly?Ser?Thr?Tyr?Gln
3455????????????????3460????????????????3465
Asp?Tyr?Gly?Val?Ser?Met?Asp?Asp?Gly?Ser?Ala?Gly?His?Ala?Val
3470????????????????3475????????????????3480
Thr?Gly?Ser?Ser?Pro?Ser?Val?Leu?Ser?Gly?Arg?Leu?Ala?Tyr?Ser
3485????????????????3490????????????????3495
Phe?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp?Thr?Ala?Cys?Ser
3500????????????????3505????????????????3510
Ser?Ser?Leu?Val?Ala?Leu?His?Leu?Ala?Cys?Gln?Ser?Leu?Arg?Asn
3515????????????????3520????????????????3525
Gly?Glu?Thr?Thr?Leu?Ala?Leu?Ala?Gly?Gly?Ala?Thr?Val?Met?Thr
3530????????????????3535????????????????3540
Asn?Pro?Met?Pro?Phe?Ile?Ala?Phe?Ser?Arg?Gln?Arg?Ala?Leu?Ala
3545????????????????3550????????????????3555
Arg?Asp?Gly?Arg?Cys?Lys?Ala?Phe?Ser?Glu?Ser?Ala?Asp?Gly?Met
3560????????????????3565????????????????3570
Thr?Leu?Ala?Glu?Gly?Val?Gly?Ile?Leu?Val?Leu?Glu?Arg?Leu?Ser
3575????????????????3580????????????????3585
Asp?Ala?Arg?Arg?Asn?Gly?His?Glu?Val?Leu?Ala?Val?Val?Arg?Gly
3590????????????????3595????????????????3600
Ser?Ala?Ile?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro
3605????????????????3610????????????????3615
Asn?Gly?Pro?Ser?Gln?Val?Arg?Val?Ile?Arg?Gln?Ala?Leu?Ala?Ala
3620????????????????3625????????????????3630
Ser?Gly?Leu?Thr?Thr?Asp?Asp?Ile?Asp?Ala?Val?Glu?Ala?His?Gly
3635????????????????3640????????????????3645
Thr?Gly?Thr?Ala?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala?Leu?His
3650????????????????3655????????????????3660
Ala?Thr?Tyr?Gly?Arg?Asp?Arg?Asp?Pro?Glu?Asn?Pro?Leu?Leu?Leu
3665????????????????3670????????????????3675
Gly?Ser?Val?Lys?Ser?Asn?Ile?Gly?His?Thr?Gln?Ser?Ala?Ala?Gly
3680????????????????3685????????????????3690
Val?Ala?Gly?Ile?Ile?Lys?Met?Val?Met?Ala?Met?Arg?His?Gly?Thr
3695????????????????3700????????????????3705
Leu?Pro?Arg?Thr?Leu?His?Ala?Thr?Glu?Pro?Ser?Ser?His?Ile?Asp
3710????????????????3715????????????????3720
Trp?Ser?Gly?Gly?Thr?Val?Arg?Leu?Val?Thr?Glu?Asn?Thr?Gly?Trp
3725????????????????3730????????????????3735
Ala?Arg?Asp?Asp?Arg?Pro?Leu?Arg?Ala?Ala?Val?Ser?Ser?Phe?Gly
3740????????????????3745????????????????3750
Ile?Ser?Gly?Thr?Asn?Ala?His?Ala?Ile?Leu?Glu?Gln?Ala?Ala?Pro
3755????????????????3760????????????????3765
Ala?Glu?Glu?Pro?Ala?Pro?Ala?Ala?Gly?Pro?Ala?Leu?Pro?Thr?Gly
3770????????????????3775????????????????3780
Gly?Thr?Leu?Pro?Trp?Ile?Leu?Ser?Ala?Ala?Ala?Pro?Ser?Ala?Leu
3785????????????????3790????????????????3795
Arg?Glu?Gln?Ala?Ala?Asn?Leu?Ala?Ala?His?Val?Thr?Ser?Gly?Ala
3800????????????????3805????????????????3810
Ala?Pro?His?Pro?Ala?Asp?Val?Gly?His?Thr?Leu?Ile?Thr?Ala?Arg
3815????????????????3820????????????????3825
Ser?Val?Leu?Glu?His?Arg?Ala?Val?Ala?Leu?Gly?Ala?Asp?Ala?Gly
3830????????????????3835????????????????3840
Glu?Leu?Thr?Asp?Ala?Leu?Ala?Ala?Phe?Gly?Ala?Gly?Glu?Ser?Thr
3845????????????????3850????????????????3855
Gly?Gln?Val?Val?His?Gly?Thr?Ala?Asp?Thr?Asp?Gly?Arg?Thr?Val
3860????????????????3865????????????????3870
Phe?Val?Phe?Pro?Gly?Gln?Gly?Ser?Gln?Trp?Ala?Gly?Met?Gly?Ala
3875????????????????3880????????????????3885
Glu?Leu?Leu?Asp?Thr?Ser?Pro?Val?Phe?Ala?Glu?Arg?Leu?His?Ala
3890????????????????3895????????????????3900
Cys?Ala?Ala?Ala?Leu?Ala?Pro?Tyr?Thr?Asp?Trp?Asp?Leu?Val?Asp
3905????????????????3910????????????????3915
Val?Val?Arg?Gln?Ala?Asp?Gly?Ala?Pro?Thr?Leu?Asp?Arg?Val?Asp
3920????????????????3925????????????????3930
Val?Val?Gln?Pro?Ala?Thr?Trp?Ala?Val?Met?Val?Ser?Leu?Ala?Glu
3935????????????????3940????????????????3945
Leu?Trp?Arg?Ala?His?Gly?Val?Thr?Pro?Asp?Ala?Val?Ile?Gly?His
3950????????????????3955????????????????3960
Ser?Gln?Gly?Glu?Ile?Ala?Ala?Ala?Val?Val?Ser?Gly?Ala?Leu?Thr
3965????????????????3970????????????????3975
Leu?Asp?Asp?Gly?Ala?Arg?Val?Val?Ala?Leu?Arg?Ser?Gln?Ala?Ile
3980????????????????3985????????????????3990
Arg?Arg?Val?Leu?Ala?Gly?Ala?Gly?Gly?Met?Met?Ser?Val?Gln?Val
3995????????????????4000????????????????4005
Ser?Ala?Ala?Glu?Ala?Glu?Gln?Tyr?Leu?Thr?Pro?His?Ala?Gly?Ala
4010????????????????4015????????????????4020
Val?Ser?Val?Ala?Ala?Val?Asn?Gly?Pro?Arg?Ser?Val?Val?Leu?Ala
4025????????????????4030????????????????4035
Gly?Thr?Pro?Glu?Ala?Leu?Asp?Ala?Leu?Gln?Ala?Glu?Phe?Ala?Ala
4040????????????????4045????????????????4050
Arg?Asp?Leu?Arg?Ala?Arg?Arg?Ile?Ala?Val?Asp?Tyr?Ala?Ser?His
4055????????????????4060????????????????4065
Thr?Ala?Gln?Val?Glu?Arg?Ile?Glu?Ala?Glu?Leu?Leu?Asp?Leu?Leu
4070????????????????4075????????????????4080
Ala?Pro?Val?Ala?Pro?Arg?Ala?Ala?Arg?Val?Pro?Phe?His?Ser?Thr
4085????????????????4090????????????????4095
Val?Thr?Gly?Ala?Thr?Leu?Asp?Thr?Thr?Gly?Met?Asp?Ala?Ala?Tyr
4100????????????????4105????????????????4110
Trp?Tyr?Arg?Asn?Leu?Arg?Gln?Thr?Val?Arg?Phe?Glu?Asp?Gly?Val
4115????????????????4120????????????????4125
Arg?Ala?Leu?Leu?Asp?Thr?Glu?His?Thr?Leu?Phe?Val?Glu?Ile?Ser
4130????????????????4135????????????????4140
Pro?His?Pro?Val?Leu?Thr?Met?Ala?Val?Gln?Ala?Thr?Ala?Glu?Glu
4145????????????????4150????????????????4155
Ala?Gly?Arg?Pro?Ala?Ala?Ala?Val?Gly?Thr?Leu?Arg?Arg?Glu?Gln
4160????????????????4165????????????????4170
Gly?Gly?Thr?Ala?Arg?Phe?Leu?Thr?Ser?Leu?Ala?Glu?Gln?Trp?Val
4175????????????????4180????????????????4185
Arg?Gly?Gly?Arg?Ala?Asp?Trp?Asn?Ala?Val?Tyr?Ala?Asp?Thr?Gly
4190????????????????4195????????????????4200
Ala?Arg?Arg?Thr?Pro?Leu?Pro?Thr?Tyr?Ala?Phe?Gln?Arg?Glu?His
4205????????????????4210????????????????4215
Leu?Trp?Ala?Val?Ser?Ala?Arg?Pro?Gln?Gly?Ser?Gly?Asp?Gly?Asp
4220????????????????4225????????????????4230
Pro?Ala?Asp?Ala?Glu?Phe?Trp?Ala?Glu?Val?Glu?Gln?Glu?Asp?Ala
4235????????????????4240????????????????4245
Glu?Ser?Leu?Ala?Ser?Arg?Leu?Glu?Leu?Asp?Arg?Glu?Ala?Leu?Ala
4250????????????????4255????????????????4260
Pro?Leu?Leu?Pro?Ala?Leu?Ser?Thr?Trp?Arg?Arg?Gly?Arg?Arg?Asp
4265????????????????4270????????????????4275
Arg?Ser?Thr?Val?Gly?Ser?Trp?Arg?Tyr?Arg?Ala?Thr?Trp?Lys?Pro
4280????????????????4285????????????????4290
Leu?Gly?Ala?Leu?Pro?Ser?Ala?Thr?Leu?Asp?Gly?Thr?Trp?Leu?Leu
4295????????????????4300????????????????4305
Val?Thr?Ala?Glu?Gly?Thr?Asp?Pro?Glu?Tyr?Ala?Ala?Ala?Val?Ala
4310????????????????4315????????????????4320
Glu?Gln?Leu?Thr?Ala?His?Gly?Ala?Arg?Thr?Val?Pro?Leu?Ala?Leu
4325????????????????4330????????????????4335
Thr?Gly?Ala?Asp?Ala?Asp?Arg?Ala?Ala?Leu?Thr?Glu?Arg?Leu?Arg
4340????????????????4345????????????????4350
Asp?Leu?Pro?Glu?Pro?Ala?Ala?Val?Val?Ser?Leu?Leu?Ala?Asp?Asp
4355????????????????4360????????????????4365
Glu?Ser?Thr?Gly?Ala?Ala?His?Pro?Val?Leu?Thr?Thr?Gly?Leu?Ala
4370????????????????4375????????????????4380
Leu?Ser?Val?Thr?Leu?Thr?Gln?Ala?Leu?Gly?Asp?Ala?Gly?Ile?Glu
4385????????????????4390????????????????4395
Ala?Pro?Leu?Trp?Ala?Leu?Thr?Arg?Gly?Ala?Val?Ser?Thr?Gly?Arg
4400????????????????4405????????????????4410
Ala?Asp?Arg?Leu?Thr?Arg?Pro?Ala?Gln?Ala?Leu?Val?Gln?Gly?Phe
4415????????????????4420????????????????4425
Gly?Trp?Thr?Ala?Ala?Leu?Glu?His?Pro?Asp?Arg?Trp?Gly?Gly?Thr
4430????????????????4435????????????????4440
Val?Asp?Leu?Pro?Glu?Thr?Leu?Asp?Arg?Arg?Ala?Gly?Glu?Arg?Leu
4445????????????????4450????????????????4455
Ala?Ala?Val?Leu?Ala?Gly?Thr?Thr?Gly?Glu?Asp?Gln?Leu?Ala?Val
4460????????????????4465????????????????4470
Arg?Ala?Ser?Gly?Val?Leu?Ala?Arg?Arg?Val?Ser?Pro?Ala?Pro?Ala
4475????????????????4480????????????????4485
Pro?Thr?Gly?Thr?Gly?Arg?Trp?Ser?Pro?Arg?Gly?Thr?Val?Leu?Val
4490????????????????4495????????????????4500
Thr?Gly?Gly?Thr?Gly?Thr?Leu?Gly?Pro?His?Leu?Ala?Arg?Trp?Leu
4505????????????????4510????????????????4515
Ala?Asp?Gln?Gly?Ala?Arg?Asp?Leu?Val?Leu?Thr?Ser?Arg?Arg?Gly
4520????????????????4525????????????????4530
Ala?Asp?Ala?Pro?Gly?Ala?Ala?Glu?Leu?Ala?Ala?Glu?Leu?Gly?Glu
4535????????????????4540????????????????4545
Arg?Gly?Cys?Arg?Val?Thr?Val?Ala?Ala?Cys?Asp?Val?Thr?Asp?Arg
4550????????????????4555????????????????4560
Glu?Ala?Val?Ala?Ala?Leu?Leu?Asp?Gly?Leu?Thr?Ala?Glu?Gly?Arg
4565????????????????4570????????????????4575
Thr?Val?Arg?Ser?Val?Phe?His?Thr?Ala?Ala?Val?Ile?Glu?Leu?Gln
4580????????????????4585????????????????4590
Ser?Ile?Glu?Glu?Thr?Ser?Leu?Asp?Ala?Phe?Ala?Lys?Val?Val?His
4595????????????????4600????????????????4605
Ala?Lys?Thr?Ala?Gly?Ala?Ala?His?Leu?Asp?Glu?Leu?Leu?Asp?Asp
4610????????????????4615????????????????4620
Asp?Gln?Leu?Asp?Ala?Phe?Val?Leu?Tyr?Ser?Ser?Thr?Ala?Gly?Met
4625????????????????4630????????????????4635
Trp?Gly?Ser?Gly?Arg?His?Ala?Ala?Tyr?Val?Ala?Ala?Asn?Ala?His
4640????????????????4645????????????????4650
Val?Asn?Ala?Leu?Ala?Glu?His?Arg?Cys?Ala?Arg?Gly?Ala?His?Gly
4655????????????????4660????????????????4665
Thr?Ala?Val?Ser?Trp?Gly?Ile?Trp?Ala?Asp?Asp?Met?Lys?Leu?Gly
4670????????????????4675????????????????4680
Arg?Val?Asp?Pro?Gly?Gln?Ile?Arg?Arg?Ser?Gly?Leu?Glu?Phe?Met
4685????????????????4690????????????????4695
Asp?Pro?Arg?Leu?Ala?Leu?Ala?Gly?Leu?Arg?Gln?Val?Leu?Asp?Gly
4700????????????????4705????????????????4710
Asp?Gln?Gly?Ala?Val?Ala?Val?Ala?Asp?Val?Asp?Trp?Asp?Arg?Tyr
4715????????????????4720????????????????4725
His?Pro?Val?Phe?Thr?Ser?Ser?Arg?Pro?Thr?Glu?Leu?Phe?Glu?Asn
4730????????????????4735????????????????4740
Val?Pro?Glu?Val?Arg?Arg?Leu?Thr?Glu?Gln?Gln?Glu?Ala?Arg?Ala
4745????????????????4750????????????????4755
Gly?Glu?Ala?Gly?Glu?Phe?Ile?His?Arg?Leu?Arg?Ser?Leu?Pro?Ala
4760????????????????4765????????????????4770
Gly?Glu?Gln?Asp?Arg?Leu?Leu?Leu?Glu?Leu?Val?Arg?Ser?Glu?Ala
4775????????????????4780????????????????4785
Ala?Thr?Val?Leu?Gly?His?Ala?Ser?Pro?Glu?Val?Leu?Ser?Glu?Arg
4790????????????????4795????????????????4800
Arg?Ala?Phe?Arg?Asp?Ile?Gly?Phe?Asp?Ser?Leu?Thr?Ala?Val?Asp
4805????????????????4810????????????????4815
Leu?Arg?Asn?Arg?Leu?Ala?Ser?Val?Thr?Gly?Leu?Thr?Leu?Pro?Ser
4820????????????????4825????????????????4830
Thr?Leu?Val?Phe?Asp?Tyr?Pro?Asp?Pro?Leu?Thr?Leu?Val?Gly?His
4835????????????????4840????????????????4845
Leu?Arg?Gly?Leu?Ala?Gly?Gly?Pro?Ala?Ala?Gly?Pro?Asp?Gly?Pro
4850????????????????4855????????????????4860
Val?Arg?Thr?Thr?Ala?Ala?Thr?Asp?Asp?Glu?Pro?Ile?Ala?Val?Val
4865????????????????4870????????????????4875
Ala?Met?Ser?Cys?Arg?Tyr?Pro?Gly?Gly?Val?Thr?Ser?Pro?Glu?Ala
4880????????????????4885????????????????4890
Leu?Trp?Glu?Leu?Ile?Ala?Ala?Gly?Ala?Asp?Ala?Ile?Thr?Gly?Phe
4895????????????????4900????????????????4905
Pro?Ala?Asp?Arg?Gly?Trp?Asp?Ala?Asp?Ala?Leu?Tyr?Asp?Pro?Asp
4910????????????????4915????????????????4920
Pro?Asp?Arg?Pro?Gly?Thr?Thr?Tyr?Ser?Thr?Gln?Gly?Gly?Phe?Leu
4925????????????????4930????????????????4935
His?Asp?Val?Ala?Asp?Phe?Asp?Ala?Gly?Phe?Phe?Gly?Ile?Ser?Pro
4940????????????????4945????????????????4950
Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu
4955????????????????4960????????????????4965
Thr?Gly?Trp?Glu?Ala?Ile?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Ala?Thr
4970????????????????4975????????????????4980
Leu?Arg?Gly?Ser?Met?Thr?Gly?Thr?Phe?Ile?Gly?Ala?Ser?Tyr?Gln
4985????????????????4990????????????????4995
Asp?Tyr?Thr?Ala?Gly?Gly?Ala?Gly?Ser?Glu?Gly?Ala?Glu?Asp?His
5000????????????????5005????????????????5010
Leu?Ile?Thr?Gly?Thr?Ile?Ser?Ser?Val?Met?Ser?Gly?Arg?Leu?Ala
5015????????????????5020????????????????5025
Tyr?Thr?Phe?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Leu?Asp?Thr?Ala
5030????????????????5035????????????????5040
Cys?Ser?Ser?Ser?Leu?Val?Ala?Leu?His?Leu?Ala?Cys?Gln?Ser?Leu
5045????????????????5050????????????????5055
Arg?Asn?Gly?Glu?Ser?Thr?Leu?Ala?Leu?Ala?Gly?Gly?Val?Ser?Val
5060????????????????5065????????????????5070
Met?Ala?Thr?Pro?Gln?Ala?Phe?Thr?Gly?Phe?Ser?Arg?Gln?Arg?Ala
5075????????????????5080????????????????5085
Met?Ala?Pro?Asp?Gly?Arg?Cys?Lys?Ala?Tyr?Ala?Glu?Gly?Ala?Asp
5090????????????????5095????????????????5100
Gly?Met?Ser?Leu?Ala?Glu?Gly?Val?Gly?Leu?Val?Leu?Val?Glu?Arg
5105????????????????5110????????????????5115
Leu?Ser?Asp?Ala?Arg?Arg?Asn?Gly?His?Pro?Val?Leu?Ala?Val?Ile
5120????????????????5125????????????????5130
Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr
5135????????????????5140????????????????5145
Ala?Pro?Asn?Gly?Pro?Ser?Gln?Ala?Arg?Val?Ile?Arg?Gln?Ala?Leu
5150????????????????5155????????????????5160
Ala?Asn?Ala?Arg?Leu?Thr?Pro?Gly?Glu?Val?Asp?Val?Val?Glu?Gly
5165????????????????5170????????????????5175
His?Gly?Thr?Gly?Thr?Ala?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala
5180????????????????5185????????????????5190
Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Asp?Arg?Pro?Gly?Asp?Arg?Pro?Leu
5195????????????????5200????????????????5205
Leu?Leu?Gly?Ser?Val?Lys?Ser?Asn?Ile?Gly?His?Thr?Gln?Met?Ala
5210????????????????5215????????????????5220
Ser?Gly?Ile?Ala?Gly?Val?Met?Lys?Met?Val?Met?Ala?Met?Arg?His
5225????????????????5230????????????????5235
Gly?Thr?Val?Pro?Arg?Thr?Leu?His?Val?Asp?Thr?Pro?Ser?Ser?His
5240????????????????5245????????????????5250
Val?Asp?Trp?Gly?Ser?Gly?Ala?Ile?Asp?Leu?Ala?Thr?Glu?Thr?Val
5255????????????????5260????????????????5265
Pro?Trp?Pro?Glu?Thr?Gly?Arg?Pro?His?Arg?Ala?Ala?Val?Ser?Ser
5270????????????????5275????????????????5280
Phe?Gly?Leu?Ser?Gly?Thr?Asn?Val?His?Thr?Ile?Val?Glu?Gln?Ala
5285????????????????5290????????????????5295
Pro?Glu?Glu?Pro?Ala?Thr?Glu?Pro?Ser?Ala?Ser?Pro?Ala?Pro?Ala
5300????????????????5305????????????????5310
Gly?Asp?Pro?Ala?Thr?Leu?Pro?Pro?Gly?Val?Pro?Val?Val?Leu?Ser
5315????????????????5320????????????????5325
Ala?Arg?Thr?Pro?Ala?Ala?Leu?Arg?Glu?Gln?Ala?Glu?Arg?Leu?Ala
5330????????????????5335????????????????5340
Gly?His?Leu?Ala?Gly?Arg?Pro?Asp?Val?Pro?Leu?Val?Asp?Leu?Ala
5345????????????????5350????????????????5355
His?Ser?Leu?Ala?Thr?Thr?Arg?Gly?Val?Leu?Glu?His?Arg?Ala?Ala
5360????????????????5365????????????????5370
Val?Leu?Thr?Gly?Asp?Arg?Asp?Gly?Leu?Leu?Arg?Ala?Leu?Thr?Ala
5375????????????????5380????????????????5385
Leu?Arg?Glu?Gly?Ala?Pro?Asp?Ala?Ser?Leu?Leu?Thr?Gly?Ala?Pro
5390????????????????5395????????????????5400
Ala?Arg?Gly?Gly?Leu?Ala?Phe?Leu?Phe?Thr?Gly?Gln?Gly?Ser?Gln
5405????????????????5410????????????????5415
Arg?Pro?Ala?Met?Gly?Arg?Asp?Leu?Tyr?Glu?Arg?His?Pro?Val?Phe
5420????????????????5425????????????????5430
Gly?Glu?Ala?Leu?Asp?Ala?Val?Leu?Thr?Arg?Phe?Asp?Gln?Glu?Leu
5435????????????????5440????????????????5445
Asp?Arg?Pro?Leu?Arg?Glu?Val?Leu?Phe?Ala?Glu?Glu?Gly?Thr?Ala
5450????????????????5455????????????????5460
Glu?Ala?Ala?Leu?Leu?Asp?Asp?Thr?Ala?Tyr?Thr?Gln?Pro?Ala?Leu
5465????????????????5470????????????????5475
Phe?Ala?Leu?Glu?Val?Ala?Leu?Tyr?Arg?Leu?Val?Glu?Ser?Trp?Gly
5480????????????????5485????????????????5490
Val?Arg?Pro?Asp?Gln?Val?Ala?Gly?His?Ser?Val?Gly?Glu?Ile?Ala
5495????????????????5500????????????????5505
Ala?Ala?His?Val?Ala?Gly?Val?Phe?Ser?Leu?Asp?Asp?Ala?Cys?Ala
5510????????????????5515????????????????5520
Leu?Val?Ala?Ala?Arg?Gly?Arg?Leu?Met?Ala?Ala?Leu?Pro?Ala?Gly
5525????????????????5530????????????????5535
Gly?Ala?Met?Val?Ala?Val?Glu?Ala?Ser?Glu?Glu?Glu?Val?Leu?Pro
5540????????????????5545????????????????5550
Leu?Leu?Glu?Gly?Gly?Glu?Asp?Arg?Ile?Ser?Leu?Ala?Ala?Val?Asn
5555????????????????5560????????????????5565
Gly?Pro?Arg?Ala?Val?Val?Ile?Ala?Gly?Asp?Glu?Glu?Pro?Val?Ala
5570????????????????5575????????????????5580
Ala?Val?Ala?Ala?Arg?Leu?Ala?Glu?Asp?Gly?Arg?Arg?Thr?Arg?Ala
5585????????????????5590????????????????5595
Leu?Lys?Val?Ser?His?Ala?Phe?His?Ser?Pro?Arg?Met?Asp?Ala?Met
5600????????????????5605????????????????5610
Leu?Asp?Asp?Phe?Ala?Arg?Val?Ala?Arg?Gly?Leu?Thr?Tyr?Glu?Thr
5615????????????????5620????????????????5625
Pro?Leu?Val?Pro?Val?Val?Ser?Thr?Val?Thr?Gly?Ala?Pro?Ala?Thr
5630????????????????5635????????????????5640
Pro?Glu?Glu?Leu?Arg?Ser?Pro?Glu?Tyr?Trp?Val?Gly?Gln?Val?Arg
5645????????????????5650????????????????5655
Ala?Thr?Val?Arg?Phe?Ala?Asp?Ala?Val?Arg?Thr?Leu?Ala?Arg?Gln
5660????????????????5665????????????????5670
Gly?Val?Thr?Ser?Cys?Leu?Glu?Leu?Gly?Pro?Asp?Gly?Thr?Leu?Ser
5675????????????????5680????????????????5685
Ala?Ala?Ala?Arg?Asp?Val?Leu?Asp?Ala?Asp?Pro?Ala?Asp?Ala?Thr
5690????????????????5695????????????????5700
Gly?Ala?Arg?Pro?Val?Thr?Val?Val?Pro?Ala?Leu?Arg?Arg?Asp?Arg
5705????????????????5710????????????????5715
Asp?Glu?Val?Pro?Phe?Leu?Thr?Ala?Ala?Leu?Ala?Arg?Leu?His?Val
5720????????????????5725????????????????5730
His?Gly?Thr?Ala?Val?Asp?Trp?Thr?Gly?Ala?Phe?Glu?Gly?Thr?Gly
5735????????????????5740????????????????5745
Ala?Arg?Arg?Val?Asp?Leu?Pro?Thr?Tyr?Ala?Phe?Gln?Arg?Ser?Arg
5750????????????????5755????????????????5760
Tyr?Trp?Pro?Asp?Thr?Thr?Phe?Thr?Pro?Ala?Thr?Ala?Ala?Gly?Pro
5765????????????????5770????????????????5775
Ala?Asp?Thr?Gly?Ala?Asp?Ala?Ala?Phe?Trp?Ser?Ala?Val?Glu?Arg
5780????????????????5785????????????????5790
Ala?Asp?Leu?Pro?Thr?Leu?Gly?Ala?Asp?Leu?Gly?Leu?Asp?Asp?Asp
5795????????????????5800????????????????5805
Thr?Leu?Ser?Ala?Leu?Val?Pro?Ala?Leu?Ser?Ser?Trp?Arg?Arg?Arg
5810????????????????5815????????????????5820
Arg?Thr?Ala?Gln?Ala?Ala?Ala?Asp?Gly?Arg?Arg?His?Arg?Ile?Val
5825????????????????5830????????????????5835
Trp?Lys?Pro?Leu?Asp?Gly?Ala?Pro?Thr?Gly?Arg?Pro?Glu?Gly?Thr
5840????????????????5845????????????????5850
Trp?Leu?Val?Leu?Arg?Pro?Thr?Gly?Thr?Ala?Ala?Pro?Glu?Thr?Ala
5855????????????????5860????????????????5865
Ala?Leu?Leu?Asp?Thr?Leu?Gly?Leu?Asp?Thr?Ala?Glu?Val?Thr?Val
5870????????????????5875????????????????5880
Asp?Leu?Ala?Ala?Pro?Asp?Arg?Ala?Ala?Leu?Ala?Asp?Thr?Leu?Arg
5885????????????????5890????????????????5895
Arg?Leu?Pro?Arg?Pro?Glu?Asp?Gly?Phe?Thr?Gly?Val?Leu?Ala?Leu
5900????????????????5905????????????????5910
Pro?Ala?Leu?Asp?Thr?Ala?Ala?Thr?Ala?Asp?Asp?Val?Ala?Gly?Thr
5915????????????????5920????????????????5925
Gly?Ala?Val?Ala?Pro?Thr?Ala?Ala?Ala?Leu?Asn?Ala?Leu?Asp?Asp
5930????????????????5935????????????????5940
Ala?Gly?Ile?Thr?Ala?Pro?Leu?Trp?Ile?Val?Thr?Arg?Gln?Ala?Val
5945????????????????5950????????????????5955
Ser?Thr?Gly?Arg?Ala?Asp?Arg?Leu?Ala?Arg?Pro?Gly?Gln?Ala?Gly
5960????????????????5965????????????????5970
Val?Trp?Gly?Leu?Gly?Arg?Val?Ala?Ala?Leu?Glu?Asn?Pro?Gly?Arg
5975????????????????5980????????????????5985
Arg?Leu?Ala?Leu?Val?Asp?Leu?Pro?Glu?Gln?Phe?Asp?Thr?Arg?Val
5990????????????????5995????????????????6000
Ala?Arg?Arg?Leu?Ala?His?Leu?Leu?Ala?Val?Pro?Gly?Thr?Glu?Asn
6005????????????????6010????????????????6015
Gln?Leu?Ala?Val?Arg?Ala?Ser?Ala?Thr?Tyr?Ala?Arg?Arg?Ile?Ala
6020????????????????6025????????????????6030
His?His?Pro?Ala?Pro?Gln?Glu?Pro?Ala?Arg?Pro?Phe?Ala?Pro?Glu
6035????????????????6040????????????????6045
Gly?Thr?Val?Leu?Ile?Thr?Gly?Gly?Thr?Gly?Ala?Leu?Gly?Ala?His
6050????????????????6055????????????????6060
Val?Ala?Arg?Leu?Leu?Ala?Gly?Arg?Gly?Thr?Pro?His?Leu?Leu?Leu
6065????????????????6070????????????????6075
Thr?Ser?Arg?Arg?Gly?Ala?Asp?Ala?Pro?Gly?Ala?Ala?Glu?Leu?Ala
6080????????????????6085????????????????6090
Ala?Glu?Leu?Arg?Glu?Leu?Gly?Ala?Glu?Val?Thr?Leu?Ala?Ala?Cys
6095????????????????6100????????????????6105
Asp?Thr?Ala?Asp?Arg?Glu?Ala?Leu?Ala?Ala?Leu?Leu?Ala?Glu?Val
6110????????????????6115????????????????6120
Pro?Ala?Asp?Arg?Pro?Leu?Thr?Thr?Val?Val?His?Ala?Ala?Gly?Val
6125????????????????6130????????????????6135
Leu?Asp?Asp?Gly?Leu?Leu?Asp?Thr?Leu?Thr?Pro?Glu?Arg?Phe?Ala
6140????????????????6145????????????????6150
Ala?Val?Leu?Asp?Ala?Lys?Ala?Arg?Ser?Ala?Ala?His?Leu?His?Glu
6155????????????????6160????????????????6165
Leu?Thr?Arg?Asp?Leu?Gly?Leu?Thr?Asp?Phe?Val?Leu?Phe?Ser?Ser
6170????????????????6175????????????????6180
Thr?Ala?Gly?Thr?Leu?Gly?Ala?Ala?Gly?Gln?Ala?Asn?Tyr?Ala?Ala
6185????????????????6190????????????????6195
Ala?Asn?Ala?Tyr?Leu?Asp?Ala?Leu?Ala?Glu?His?Arg?Arg?Glu?Gln
6200????????????????6205????????????????6210
Gly?Leu?Pro?Ala?Thr?Ser?Val?Ala?Trp?Gly?Pro?Trp?Ser?Gly?Thr
6215????????????????6220????????????????6225
Gly?Met?Ala?Gly?Glu?Gly?Thr?Gly?Val?Glu?Asp?Arg?Val?Arg?Arg
6230????????????????6235????????????????6240
Gly?Gly?Phe?Thr?Pro?Met?Ser?Pro?Glu?Asp?Ala?Leu?Ala?Ala?Leu
6245????????????????6250????????????????6255
Asp?Ala?Ala?Val?Gly?His?Arg?Asp?Thr?Ala?Leu?Leu?Val?Ala?Asp
6260????????????????6265????????????????6270
Ile?Asp?Trp?Gln?Arg?Tyr?Ala?Thr?Val?Phe?Ala?Pro?His?Arg?Ala
6275????????????????6280????????????????6285
Leu?Val?Gly?Asp?Leu?Pro?Glu?Val?Arg?Ala?Thr?Val?Gly?Ala?Ala
6290????????????????6295????????????????6300
Thr?Ala?His?Gly?Asp?Thr?Glu?Pro?Ala?Leu?Arg?Arg?Gln?Val?Ala
6305????????????????6310????????????????6315
Ala?Leu?Thr?Gly?Pro?Ala?Arg?Glu?Arg?Tyr?Val?Leu?Asp?Phe?Leu
6320????????????????6325????????????????6330
Arg?Ala?Gln?Val?Ala?Ala?Val?Leu?Gly?His?Pro?Asp?Pro?Asp?Ala
6335????????????????6340????????????????6345
Val?Glu?Ala?Asp?Gln?Ala?Phe?Thr?Asp?Leu?Gly?Phe?Asp?Ser?Leu
6350????????????????6355????????????????6360
Thr?Thr?Val?Glu?Leu?Arg?Asn?Thr?Leu?Gly?Ala?Thr?Thr?Gly?Leu
6365????????????????6370????????????????6375
Arg?Leu?Pro?Ala?Thr?Leu?Val?Tyr?Asp?His?Pro?Thr?Ala?Arg?Asp
6380????????????????6385????????????????6390
Leu?Ala?Ala?His?Leu?Leu?Thr?Glu?Ile?Leu?Gly?Asp?Leu?Pro?Glu
6395????????????????6400????????????????6405
Pro?Ala?Ala?Gly?Gly?Asn?Ala?Ala?Gly?Glu?Ala?Pro?Arg?Ala?Thr
6410????????????????6415????????????????6420
Glu?Thr?Asp?Pro?Val?Val?Val?Val?Gly?Met?Gly?Cys?Arg?Phe?Pro
6425????????????????6430????????????????6435
Gly?Gly?Val?Glu?Ser?Pro?Glu?Glu?Leu?Trp?Gln?Leu?Leu?Gly?Glu
6440????????????????6445????????????????6450
Gly?Arg?Asp?Ala?Val?Ser?Gly?Phe?Pro?Ala?Asp?Arg?Gly?Trp?Asp
6455????????????????6460????????????????6465
Leu?Asp?Ser?Leu?Ala?Arg?Gly?Gly?Ser?Ala?Thr?Leu?Glu?Gly?Gly
6470????????????????6475????????????????6480
Phe?Leu?Gln?Gly?Ala?Gly?Leu?Phe?Asp?Ala?Ser?Phe?Phe?Gly?Ile
6485????????????????6490????????????????6495
Ser?Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu
6500????????????????6505????????????????6510
Leu?Glu?Thr?Ser?Trp?Glu?Ala?Leu?Glu?Arg?Ala?Gly?Ile?Asp?Pro
6515????????????????6520????????????????6525
Thr?Gly?Leu?Arg?Ser?Ser?Ala?Thr?Gly?Val?Phe?Val?Gly?Thr?Asn
6530????????????????6535????????????????6540
Gly?Gln?Asp?Tyr?Ala?Thr?Val?Leu?Arg?Arg?Gly?Thr?Thr?Asp?Val
6545????????????????6550????????????????6555
Arg?Gly?His?Ala?Ala?Thr?Gly?Thr?Thr?Ala?Ser?Val?Met?Ser?Gly
6560????????????????6565????????????????6570
Arg?Leu?Ser?Tyr?Thr?Leu?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Val
6575????????????????6580????????????????6585
Asp?Thr?Ala?Cys?Ser?Ser?Ala?Leu?Val?Ala?Leu?His?Met?Ala?Ala
6590????????????????6595????????????????6600
Gly?Ala?Leu?Arg?Ser?Gly?Glu?Cys?Thr?Leu?Ala?Leu?Ala?Gly?Gly
6605????????????????6610????????????????6615
Val?Ser?Val?Met?Ala?Ser?Pro?Asp?Ala?Phe?Val?Glu?Phe?Thr?Ala
6620????????????????6625????????????????6630
Gln?Gly?Gly?Leu?Ala?Gly?Asp?Gly?Arg?Cys?Lys?Ala?Phe?Ala?Asp
6635????????????????6640????????????????6645
Ala?Ala?Asp?Gly?Thr?Ala?Trp?Gly?Glu?Gly?Ala?Gly?Val?Leu?Val
6650????????????????6655????????????????6660
Leu?Glu?Arg?Leu?Ser?Asp?Ala?Arg?Arg?His?Gly?His?Pro?Val?Leu
6665????????????????6670????????????????6675
Ala?Val?Leu?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn
6680????????????????6685????????????????6690
Gly?Leu?Thr?Ala?Pro?Asn?Gly?Arg?Ala?Gln?Gln?Arg?Val?Ile?Arg
6695????????????????6700????????????????6705
Gln?Ala?Leu?Ala?Asp?Ala?His?Leu?Thr?Pro?Ala?Glu?Val?Asp?Ala
6710????????????????6715????????????????6720
Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr?Leu?Gly?Asp?Pro?Ile?Glu
6725????????????????6730????????????????6735
Ala?His?Ala?Leu?Ile?Ala?Ala?Tyr?Gly?Glu?Gly?Arg?Asp?Pro?Glu
6740????????????????6745????????????????6750
Gln?Pro?Leu?Leu?Leu?Gly?Thr?Val?Lys?Ser?Asn?Leu?Gly?His?Thr
6755????????????????6760????????????????6765
Gln?Ala?Ala?Ala?Gly?Ala?Ala?Gly?Val?Ile?Lys?Thr?Val?Leu?Ala
6770????????????????6775????????????????6780
Leu?Gly?His?Gly?Glu?Leu?Pro?Arg?Thr?Leu?His?Val?Asp?Ala?Pro
6785????????????????6790????????????????6795
Ser?Ser?His?Val?Asp?Trp?Ser?Asp?Gly?Thr?Val?Glu?Leu?Leu?Arg
6800????????????????6805????????????????6810
Glu?His?Arg?Ala?Trp?Pro?Glu?Thr?Gly?Arg?Ala?Arg?Arg?Ala?Gly
6815????????????????6820????????????????6825
Val?Ser?Ala?Phe?Gly?Val?Ser?Gly?Thr?Asn?Ala?His?Val?Ile?Leu
6830????????????????6835????????????????6840
Glu?Gln?Pro?Glu?Pro?Ala?Thr?Ala?Glu?Thr?Pro?Glu?Pro?Val?Thr
6845????????????????6850????????????????6855
Glu?Pro?Ser?Val?Val?Pro?Trp?Leu?Val?Ser?Ala?Arg?Ser?Glu?Asp
6860????????????????6865????????????????6870
Ala?Leu?Ala?Ala?Gln?Thr?Ala?Arg?Leu?Thr?Ala?Phe?Thr?Gln?Ala
6875????????????????6880????????????????6885
Arg?Pro?Glu?Val?Pro?Ala?Leu?Asp?Thr?Ala?Tyr?Ser?Leu?Ala?Thr
6890????????????????6895????????????????6900
Gly?Arg?Gly?Ala?Phe?Ala?His?Arg?Ala?Val?His?Leu?Val?Thr?Ala
6905????????????????6910????????????????6915
Gly?Gly?Glu?Pro?Leu?Glu?Thr?Val?Arg?Asp?Arg?Ala?Trp?Glu?Arg
6920????????????????6925????????????????6930
Arg?Leu?Ala?Leu?Leu?Phe?Ser?Gly?Gln?Gly?Ser?Gln?Arg?Ala?Gly
6935????????????????6940????????????????6945
Met?Gly?Arg?Glu?Leu?Tyr?Glu?Arg?Phe?Pro?Val?Phe?Ala?Glu?Ala
6950????????????????6955????????????????6960
Leu?Asp?Ser?Val?Val?Ala?Arg?Leu?Asp?Thr?Gly?Leu?Glu?Arg?Ser
6965????????????????6970????????????????6975
Leu?Arg?Glu?Val?Leu?Phe?Ala?Glu?Glu?Gly?Ser?Glu?Ala?Ala?Ala
6980????????????????6985????????????????6990
Leu?Leu?Glu?Ala?Thr?Gly?Tyr?Thr?Gln?Pro?Ala?Leu?Phe?Ala?Val
6995????????????????7000????????????????7005
Glu?Val?Ala?Leu?Phe?Arg?Leu?Val?Glu?Ser?Trp?Gly?Val?Ala?Pro
7010????????????????7015????????????????7020
Glu?Phe?Val?Ala?Gly?His?Ser?Val?Gly?Glu?Ile?Ala?Ala?Ala?His
7025????????????????7030????????????????7035
Val?Ala?Gly?Val?Phe?Ser?Leu?Asp?Asp?Ala?Cys?Ala?Leu?Val?Ala
7040????????????????7045????????????????7050
Ala?Arg?Ala?Arg?Leu?Met?Gln?Glu?Leu?Pro?Thr?Gly?Gly?Ala?Met
7055????????????????7060????????????????7065
Val?Ala?Val?Arg?Ala?Thr?Glu?Ala?Glu?Val?Val?Pro?Arg?Leu?Thr
7070????????????????7075????????????????7080
Glu?Gly?Leu?Ser?Leu?Ala?Ala?Val?Asn?Gly?Pro?Asp?Ser?Val?Val
7085????????????????7090????????????????7095
Ile?Ala?Gly?Glu?Gln?Glu?Glu?Val?Leu?Ala?Leu?Ala?Ala?Glu?Phe
7100????????????????7105????????????????7110
Ala?Gly?Glu?Gly?His?Lys?Thr?Gln?Pro?Leu?Pro?Val?Ser?His?Ala
7115????????????????7120????????????????7125
Phe?His?Ser?Ala?Leu?Met?Glu?Pro?Met?Leu?Ala?Glu?Phe?Arg?Arg
7130????????????????7135????????????????7140
Val?Ala?Glu?Ser?Leu?Glu?Tyr?Ala?Glu?Pro?Arg?Val?Pro?Val?Val
7145????????????????7150????????????????7155
Ser?Asn?Val?Thr?Gly?Ala?Leu?Ala?Gln?Pro?Gly?Gln?Leu?Thr?Asp
7160????????????????7165????????????????7170
Pro?Glu?Tyr?Trp?Val?Arg?His?Val?Arg?Glu?Thr?Val?Arg?Phe?Ala
7175????????????????7180????????????????7185
Asp?Gly?Val?Arg?Ala?Leu?Ala?Glu?Ala?Gly?Ala?Asp?Ala?Tyr?Leu
7190????????????????7195????????????????7200
Glu?Ile?Gly?Pro?Asp?Gly?Val?Leu?Thr?Gly?Met?Ala?Ala?Arg?Val
7205????????????????7210????????????????7215
Leu?Asp?Thr?Ala?Ala?Asp?Gly?Ser?Gly?Gly?Val?Ser?Val?Pro?Ala
7220????????????????7225????????????????7230
Leu?Arg?Lys?Asp?Arg?Pro?Glu?Glu?His?Ser?Leu?Leu?Thr?Ala?Leu
7235????????????????7240????????????????7245
Ala?Arg?Leu?His?Thr?Ala?Gly?Val?Ala?Val?Asp?Trp?Thr?Ala?Trp
7250????????????????7255????????????????7260
Phe?Thr?Gly?Thr?Gly?Ala?Arg?Arg?Thr?Asp?Leu?Pro?Thr?Tyr?Ala
7265????????????????7270????????????????7275
Phe?Gln?Arg?Glu?Leu?Tyr?Trp?Pro?Glu?Pro?Ala?Thr?Gly?Pro?His
7280????????????????7285????????????????7290
Thr?Ala?Thr?Ala?Gln?Asp?Pro?Ala?Asp?Ala?Ala?Phe?Trp?Ala?Ala
7295????????????????7300????????????????7305
Val?Glu?Arg?Glu?Asp?Leu?Glu?Ser?Leu?Ser?Ala?Thr?Leu?Asp?Leu
7310????????????????7315????????????????7320
Asp?Asp?Ala?Val?Leu?Ser?Asn?Val?Leu?Pro?Ala?Leu?Ser?Thr?Trp
7325????????????????7330????????????????7335
Arg?Arg?Gly?Leu?Ser?Glu?Arg?Thr?Leu?Leu?Asp?Gly?Trp?Arg?Tyr
7340????????????????7345????????????????7350
Arg?Val?Thr?Trp?Gln?Pro?Val?Pro?Leu?Gly?Asn?Thr?Ala?Asp?Asp
7355????????????????7360????????????????7365
Gly?Thr?Gly?Arg?Pro?Trp?Leu?Val?Leu?Thr?Leu?Ala?Gly?His?Asp
7370????????????????7375????????????????7380
Asp?Ala?Trp?Thr?Gln?Ala?Leu?Ala?Ala?Thr?Phe?Gly?Glu?His?Thr
7385????????????????7390????????????????7395
Val?His?Leu?Ala?Val?Pro?Ala?Asp?Glu?Asp?Gly?Thr?Ala?Ala?Leu
7400????????????????7405????????????????7410
Leu?Asp?Gly?Ala?Ala?Asp?Gly?Thr?Ala?Tyr?Ala?Gly?Val?Leu?Ser
7415????????????????7420????????????????7425
Leu?Leu?Ala?Gly?Thr?Ala?Thr?Asp?Gly?Thr?Ala?Arg?Pro?Asp?Thr
7430????????????????7435????????????????7440
Leu?Leu?Arg?Leu?Leu?Ala?Ala?Ala?Gly?Ile?Asp?Ala?Pro?Leu?Trp
7445????????????????7450????????????????7455
Cys?Val?Thr?Arg?Asp?Ala?Val?Ser?Val?Gly?Arg?Ser?Asp?Pro?Ala
7460????????????????7465????????????????7470
Ala?Asp?Pro?Asp?Arg?Ala?Ala?Leu?Trp?Gly?Leu?Gly?Arg?Val?Leu
7475????????????????7480????????????????7485
Ala?Leu?Asp?Glu?Pro?Glu?Arg?Trp?Gly?Gly?Leu?Val?Asp?Val?Asp
7490????????????????7495????????????????7500
His?Val?Ala?Asp?Ala?Arg?Thr?Val?Asp?Arg?Leu?Arg?Ala?Val?Leu
7505????????????????7510????????????????7515
Thr?Val?Ala?Arg?Thr?Asp?Gly?Pro?Ala?Glu?Asp?Gln?Val?Ala?Leu
7520????????????????7525????????????????7530
Arg?Ala?Ser?Gly?Ala?Phe?Gly?Arg?Arg?Leu?Ser?Arg?Ala?Ala?Ala
7535????????????????7540????????????????7545
Pro?Ala?Pro?Asp?Ile?Thr?Trp?His?Pro?Ala?Gly?Thr?Val?Leu?Val
7550????????????????7555????????????????7560
Thr?Gly?Arg?Ala?Glu?Gly?Phe?Gly?Gly?His?Val?Ala?Arg?Trp?Leu
7565????????????????7570????????????????7575
Ala?Ala?His?Gly?Ala?Thr?Gly?Val?Leu?Leu?Ala?Gly?Pro?Ala?Gly
7580????????????????7585????????????????7590
Pro?Glu?Asp?Ala?Ala?Thr?Thr?Ala?Leu?Arg?Ala?Glu?Val?Glu?Ala
7595????????????????7600????????????????7605
Leu?Gly?Ala?Thr?Leu?Thr?Val?Val?Arg?His?Pro?Asp?Pro?Ala?Asp
7610????????????????7615????????????????7620
Ala?Ala?Pro?Leu?Thr?Glu?Ala?Leu?Ala?Ala?Gln?Ala?Asp?Asp?Arg
7625????????????????7630????????????????7635
Pro?Leu?Thr?Ala?Val?Leu?His?Thr?Gly?Asp?Thr?Gly?Glu?Glu?Thr
7640????????????????7645????????????????7650
Pro?Gly?Val?Thr?Gly?Ala?Arg?Ala?Ala?Tyr?Glu?Ala?Leu?Thr?Thr
7655????????????????7660????????????????7665
Ala?Val?Gly?Asp?Arg?Asp?Leu?Asp?Ala?Phe?Val?Val?Phe?Gly?Ser
7670????????????????7675????????????????7680
Ile?Ser?Ala?Val?Trp?Gly?Val?Gly?Gly?Gln?Gly?Ala?Gly?Ala?Ala
7685????????????????7690????????????????7695
Ala?Gly?Val?Cys?Leu?Asp?Ala?Leu?Val?Gln?Arg?His?Arg?Ala?His
7700????????????????7705????????????????7710
Gly?Thr?Asn?Ala?Val?Ser?Val?Ser?Trp?Gly?Ala?Trp?Gln?Gly?Ala
7715????????????????7720????????????????7725
Gly?Pro?Asp?Gly?Leu?Ala?Ala?His?Leu?Arg?Ala?Asn?Gly?Leu?Pro
7730????????????????7735????????????????7740
Ala?Met?Glu?Pro?Ala?Arg?Ala?Leu?Asp?Ala?Leu?Ala?Pro?Ala?Ile
7745????????????????7750????????????????7755
Gly?Glu?Ala?Ala?Ala?Asn?Pro?Ala?Ala?Pro?Ala?Ser?Val?Thr?Val
7760????????????????7765????????????????7770
Ala?Asp?Val?Ala?Trp?Asp?Arg?Phe?Ala?Pro?Ala?Phe?Thr?Arg?Thr
7775????????????????7780????????????????7785
Arg?Ala?Gly?Leu?Leu?Leu?Thr?Gly?Val?Pro?Glu?Ala?Arg?Glu?Ala
7790????????????????7795????????????????7800
Leu?Ser?Thr?Thr?Gly?Gly?Asp?Gly?Ala?Asp?Ala?Gly?Thr?Ala?Ser
7805????????????????7810????????????????7815
Ala?Leu?Arg?Glu?Arg?Leu?Arg?Gln?Ser?Asp?Pro?Ser?Glu?Arg?Pro
7820????????????????7825????????????????7830
Arg?Thr?Leu?Leu?Asp?Thr?Val?Leu?Thr?Glu?Ile?Ala?Ser?Val?Leu
7835????????????????7840????????????????7845
Gly?His?Thr?Gly?Ala?Ala?Ala?Val?Pro?Ala?Glu?Asn?Ala?Phe?Asn
7850????????????????7855????????????????7860
Asp?Leu?Gly?Phe?Asp?Ser?Leu?Thr?Ala?Val?Asp?Leu?Arg?Asn?Arg
7865????????????????7870????????????????7875
Leu?Thr?Thr?Ala?Thr?Gly?Leu?Thr?Leu?Pro?Ala?Thr?Leu?Val?Phe
7880????????????????7885????????????????7890
Asp?Tyr?Pro?Thr?Pro?Ala?Ala?Leu?Ala?Ala?His?Leu?Leu?Thr?Glu
7895????????????????7900????????????????7905
Leu?Leu?Gly?Glu?Asp?Thr?Gly?Pro?Gly?Thr?Gly?Ala?Pro?Val?Ala
7910????????????????7915????????????????7920
Arg?Ala?Ala?Ala?Asp?Ala?Asp?Asp?Pro?Val?Val?Ile?Val?Gly?Met
7925????????????????7930????????????????7935
Ser?Cys?Arg?Tyr?Pro?Gly?Asp?Val?Arg?Ser?Pro?Glu?Asp?Leu?Trp
7940????????????????7945????????????????7950
Glu?Leu?Val?Gly?Ala?Gly?Thr?Asp?Ala?Ile?Gly?Gly?Phe?Pro?Thr
7955????????????????7960????????????????7965
Asp?Arg?Gly?Trp?Asp?Leu?Glu?Lys?Leu?Leu?His?Gly?Asp?Glu?Asp
7970????????????????7975????????????????7980
Gly?Arg?Gly?Arg?Ser?Val?Thr?Arg?Glu?Gly?Gly?Phe?Leu?Tyr?Asp
7985????????????????7990????????????????7995
Val?Ala?Asp?Phe?Asp?Pro?Ala?Phe?Phe?Gly?Ile?Ser?Pro?Arg?Glu
8000????????????????8005????????????????8010
Ala?Leu?Val?Ile?Asp?Pro?Gln?Gln?Arg?Ile?Val?Leu?Gln?Ala?Ala
8015????????????????8020????????????????8025
Trp?Glu?Ala?Leu?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Ala?Val?Leu?Arg
8030????????????????8035????????????????8040
Gly?Gly?Asp?Thr?Gly?Val?Phe?Val?Gly?Gly?Gly?Ser?Gly?Asp?Tyr
8045????????????????8050????????????????8055
Arg?Pro?Ala?Ile?Gly?Gln?Ser?Gly?His?Val?Glu?Thr?Ala?Gln?Ser
8060????????????????8065????????????????8070
Ala?Ser?Leu?Leu?Ser?Gly?Arg?Leu?Ser?Tyr?Thr?Leu?Gly?Leu?Glu
8075????????????????8080????????????????8085
Gly?Pro?Ser?Val?Ser?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Thr
8090????????????????8095????????????????8100
Ala?Leu?His?Leu?Ala?Ala?Gln?Ala?Ile?Arg?Ser?Gly?Glu?Cys?Ser
8105????????????????8110????????????????8115
Leu?Ala?Leu?Ala?Gly?Gly?Val?Thr?Val?Met?Ser?Thr?Pro?Val?Gly
8120????????????????8125????????????????8130
Phe?Val?Glu?Phe?Gly?Glu?Met?Gly?Ala?Leu?Ser?Pro?Asp?Gly?Arg
8135????????????????8140????????????????8145
Cys?Lys?Pro?Phe?Ser?Asp?Ala?Ala?Asp?Gly?Thr?Ala?Trp?Ser?Glu
8150????????????????8155????????????????8160
Gly?Val?Gly?Met?Leu?Val?Val?Glu?Arg?Leu?Ser?Glu?Ala?Arg?Arg
8165????????????????8170????????????????8175
Arg?Gly?His?Glu?Val?Leu?Ala?Val?Leu?Arg?Gly?Ser?Ala?Ile?Asn
8180????????????????8185????????????????8190
Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser
8195????????????????8200????????????????8205
Gln?Gln?Arg?Val?Ile?Arg?Lys?Ala?Leu?Ala?Ala?Ala?Gly?Leu?Thr
8210????????????????8215????????????????8220
Ala?Arg?Glu?Val?Asp?Ala?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Thr
8225????????????????8230????????????????8235
Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly
8240????????????????8245????????????????8250
Gln?Asp?Arg?Pro?Glu?Gly?Gln?Pro?Leu?Leu?Leu?Gly?Ser?Val?Lys
8255????????????????8260????????????????8265
Ser?Asn?Ile?Gly?His?Ser?Gln?Ala?Ala?Ser?Gly?Val?Ala?Gly?Ile
8270????????????????8275????????????????8280
Ile?Lys?Met?Val?Leu?Ala?Met?Arg?His?Gly?Thr?Leu?Pro?Arg?Thr
8285????????????????8290????????????????8295
Leu?His?Ala?Glu?Lys?Pro?Ser?Arg?His?Val?Ala?Trp?Asp?Pro?Asp
8300????????????????8305????????????????8310
Ala?Val?His?Leu?Leu?Thr?Glu?Ala?Ala?Asp?Trp?Pro?Glu?Thr?Gly
8315????????????????8320????????????????8325
Arg?Pro?Arg?Arg?Ala?Ala?Val?Ser?Ser?Phe?Gly?Ala?Ser?Gly?Thr
8330????????????????8335????????????????8340
Asn?Ala?His?Val?Ile?Leu?Glu?Gln?Ala?Pro?Thr?Gly?Pro?Ala?Ala
8345????????????????8350????????????????8355
Pro?Glu?Arg?Asp?Thr?Glu?Pro?Ala?Thr?His?Ala?Thr?Asp?Ala?Ala
8360????????????????8365????????????????8370
Arg?Leu?Leu?Pro?Leu?Pro?Leu?Ser?Ala?Ala?Thr?Ala?Asp?Ser?Leu
8375????????????????8380????????????????8385
Thr?Glu?Gln?Ala?Ala?Arg?Leu?Arg?Asp?Arg?Leu?Thr?Ala?Gly?Ala
8390????????????????8395????????????????8400
Ala?Gln?Pro?Pro?Ala?Thr?Ala?Asp?Leu?Ala?Leu?Ser?Leu?Gly?Thr
8405????????????????8410????????????????8415
Thr?Arg?Ser?Ala?Phe?Glu?His?Arg?Ala?Val?Leu?Ala?Val?Ala?Gly
8420????????????????8425????????????????8430
Arg?Asp?Asp?Leu?Leu?Asp?Ala?Leu?Thr?Ala?Leu?Ala?Glu?Asp?Arg
8435????????????????8440????????????????8445
Ala?His?Pro?Ala?Val?Leu?Arg?Gly?Arg?Ala?Ala?Pro?Gly?Gly?Arg
8450????????????????8455????????????????8460
Thr?Ala?Phe?Leu?Phe?Pro?Gly?Gln?Gly?Ser?Gln?Arg?Pro?Gly?Ala
8465????????????????8470????????????????8475
Gly?Arg?Ala?Leu?Tyr?Ala?Arg?Phe?Pro?Val?Phe?Ala?Thr?Ala?Leu
8480????????????????8485????????????????8490
Asp?Glu?Val?Leu?Ala?His?Phe?Asp?Gln?Glu?Leu?Glu?Arg?Pro?Leu
8495????????????????8500????????????????8505
Arg?Asp?Val?Met?Phe?Ala?Asp?Glu?Gly?Thr?Pro?Glu?Ala?Ala?Leu
8510????????????????8515????????????????8520
Leu?Asp?Arg?Thr?Gly?Trp?Thr?Gln?Pro?Ala?Leu?Phe?Ala?Leu?Gly
8525????????????????8530????????????????8535
Val?Ala?Leu?Tyr?Arg?Leu?Val?Glu?Ser?Trp?Gly?Val?Arg?Pro?Asp
8540????????????????8545????????????????8550
Leu?Leu?Ala?Gly?His?Ser?Val?Gly?Glu?Leu?Ala?Ala?Ala?His?Val
8555????????????????8560????????????????8565
Ala?Gly?Val?Leu?Ser?Leu?Pro?Asp?Ala?Cys?Arg?Val?Val?Ser?Ala
8570????????????????8575????????????????8580
Arg?Ala?Arg?Leu?Met?Glu?Ala?Leu?Pro?Ala?Gly?Gly?Ala?Met?Leu
8585????????????????8590????????????????8595
Ala?Val?Arg?Ala?Thr?Glu?Asp?Glu?Ile?Ala?Pro?Tyr?Leu?Thr?Asp
8600????????????????8605????????????????8610
Gln?Ile?Cys?Leu?Ala?Ala?Val?Asn?Gly?Pro?Glu?Ser?Val?Val?Val
8615????????????????8620????????????????8625
Ser?Gly?Asp?Glu?Lys?Ala?Val?Thr?Ala?Leu?Ala?Glu?Ala?Leu?Ala
8630????????????????8635????????????????8640
Glu?Gln?Gly?Arg?Lys?Thr?Arg?Arg?Leu?Arg?Val?Ser?His?Ala?Phe
8645????????????????8650????????????????8655
His?Ser?Leu?His?Met?Asp?Ala?Met?Leu?Gln?Asp?Phe?Glu?Arg?Val
8660????????????????8665????????????????8670
Thr?Arg?Ser?Val?Ser?Tyr?Ala?Pro?Pro?Thr?Leu?Pro?Leu?Val?Ser
8675????????????????8680????????????????8685
Asn?Leu?Thr?Gly?Asp?Ala?Ala?Thr?Asp?Ala?Gln?Val?Cys?Asp?Pro
8690????????????????8695????????????????8700
Gly?Tyr?Trp?Val?Arg?His?Val?Arg?Glu?Ala?Val?Arg?Phe?Gly?Asp
8705????????????????8710????????????????8715
Gly?Val?Arg?Thr?Leu?Ala?Gly?Arg?Gly?Ala?Thr?Arg?Tyr?Leu?Glu
8720????????????????8725????????????????8730
Leu?Gly?Pro?Asp?Gly?Ile?Leu?Cys?Gly?Leu?Ala?Gln?Glu?Thr?Leu
8735????????????????8740????????????????8745
Asp?Thr?Leu?Ala?Asp?Glu?Asn?Arg?Pro?Ala?Pro?Thr?Ala?Val?Pro
8750????????????????8755????????????????8760
Ala?Leu?Arg?Thr?Gly?Arg?Asp?Glu?Glu?Gln?Ala?Leu?Ile?Thr?Ala
8765????????????????8770????????????????8775
Val?Ala?Arg?Leu?His?Ala?Ala?Gly?Gln?Gly?Leu?Asp?Trp?Ala?Ala
8780????????????????8785????????????????8790
Leu?Leu?Asp?Gly?Thr?Gly?Ala?Arg?Arg?Val?Asp?Leu?Pro?Thr?Tyr
8795????????????????8800????????????????8805
Pro?Phe?Arg?Arg?Leu?Arg?Phe?Trp?Pro?Asp?Glu?Ala?Pro?Ala?Ala
8810????????????????8815????????????????8820
Ala?Thr?Gly?Thr?Thr?Ala?Asp?Ala?Gly?Asp?Ala?Ala?Phe?Trp?Ala
8825????????????????8830????????????????8835
Ala?Val?Gln?Asp?Glu?Gln?Phe?Asp?Ser?Leu?Ala?Gly?Glu?Leu?Gly
8840????????????????8845????????????????8850
Val?Asp?Gly?Asp?Ala?Leu?Leu?Arg?Val?Leu?Pro?Ala?Leu?Arg?Asp
8855????????????????8860????????????????8865
Trp?Arg?Arg?Lys?His?Gly?Asp?Gln?Thr?Thr?Val?Asp?Gly?Trp?Arg
8870????????????????8875????????????????8880
Gln?Arg?Ile?Ala?Trp?Arg?Pro?Leu?Asn?Arg?Ala?Thr?Ala?Gly?Thr
8885????????????????8890????????????????8895
Pro?Ala?Gly?Thr?Trp?Leu?Ala?Val?Val?Pro?Ala?Asp?His?Ala?Asp
8900????????????????8905????????????????8910
His?Pro?Trp?Thr?Ser?Ala?Val?Leu?Ala?Ala?Leu?Gly?Ala?Gly?Ala
8915????????????????8920????????????????8925
Gln?Val?Leu?Glu?Val?Ser?Gly?Lys?Asp?Arg?Ala?Gly?Leu?Ala?Ala
8930????????????????8935????????????????8940
Ala?Ile?Arg?Glu?Arg?Leu?Asp?Ala?Thr?Gly?Pro?Phe?Thr?Gly?Val
8945????????????????8950????????????????8955
Val?Ser?Leu?Leu?Ala?Val?Ala?Gly?Glu?Pro?Gly?Asp?Gly?Thr?Gly
8960????????????????8965????????????????8970
Ala?Leu?Pro?Gly?Gly?Val?Pro?Ala?Gly?Ala?Ala?Leu?Thr?Ala?Thr
8975????????????????8980????????????????8985
Leu?Val?Gln?Ala?Leu?Gly?Asp?Ala?Arg?Thr?Asp?Ala?Pro?Leu?Trp
8990????????????????8995????????????????9000
Cys?Leu?Thr?Arg?Gly?Ala?Ala?Ala?Val?Ser?Pro?Ala?Glu?Thr?Val
9005????????????????9010????????????????9015
Ala?Ala?Pro?Leu?Gln?Ala?Ala?Val?His?Gly?Leu?Gly?Arg?Val?Ala
9020????????????????9025????????????????9030
Ala?Leu?Glu?His?Pro?Gln?Arg?Trp?Gly?Gly?Thr?Val?Asp?Leu?Pro
9035????????????????9040????????????????9045
Leu?Ala?Val?Asp?Ala?Arg?Thr?Ala?Glu?Arg?Leu?Ala?Ala?Val?Leu
9050????????????????9055????????????????9060
Ala?Asp?Pro?Glu?Gly?Glu?Asp?Gln?Leu?Ala?Val?Arg?Pro?Gly?Ala
9065????????????????9070????????????????9075
Val?Phe?Gly?Arg?Arg?Leu?Ala?Ala?Val?Arg?Pro?Gly?Thr?Pro?Arg
9080????????????????9085????????????????9090
Asp?Trp?Lys?Pro?Thr?Gly?Thr?Val?Leu?Ile?Thr?Gly?Gly?Thr?Gly
9095????????????????9100????????????????9105
Ala?Leu?Gly?Ala?Arg?Thr?Ala?Arg?Arg?Leu?Ala?Gly?Ala?Gly?Ala
9110????????????????9115????????????????9120
Arg?Arg?Leu?Val?Leu?Leu?Ser?Arg?Ser?Gly?Pro?Asp?Ala?Pro?Gly
9125????????????????9130????????????????9135
Ala?Gly?Glu?Leu?Ala?Ala?Asp?Leu?Arg?Ala?Leu?Gly?Ala?Glu?Pro
9140????????????????9145????????????????9150
Val?Ile?Thr?Ala?Cys?Asp?Thr?Ala?Asp?Arg?Lys?Ala?Leu?Ala?Ala
9155????????????????9160????????????????9165
Val?Leu?Ala?Ala?Ile?Pro?Glu?Asp?Ala?Pro?Leu?Thr?Gly?Val?Ile
9170????????????????9175????????????????9180
His?Thr?Ala?Gly?Val?Leu?Asp?Asp?Gly?Val?Val?Asp?Gly?Leu?Thr
9185????????????????9190????????????????9195
Pro?Glu?Arg?Phe?Ala?Thr?Val?Phe?Arg?Ala?Lys?Val?Ala?Ser?Ala
9200????????????????9205????????????????9210
Leu?Leu?Leu?Asp?Glu?Leu?Thr?Arg?Ala?His?Asp?Leu?Glu?Val?Phe
9215????????????????9220????????????????9225
Ala?Leu?Phe?Ser?Ser?Ala?Ser?Ala?Ala?Val?Gly?Asn?Pro?Gly?Gln
9230????????????????9235????????????????9240
Gly?Thr?Tyr?Ala?Ala?Ala?Asn?Ala?Val?Leu?Asp?Ala?Leu?Ala?Glu
9245????????????????9250????????????????9255
Gln?Arg?Arg?Ala?Glu?Gly?Leu?Pro?Ala?Thr?Ser?Val?Ala?Tyr?Gly
9260????????????????9265????????????????9270
Ala?Trp?Gly?Gly?Glu?Gly?Met?Ala?Asp?Gly?Val?Arg?Ala?Ala?Ala
9275????????????????9280????????????????9285
Leu?Ala?Arg?Arg?Thr?Gly?Ile?Arg?Pro?Leu?Asp?Pro?Asp?Leu?Ala
9290????????????????9295????????????????9300
Val?Leu?Ala?Leu?Arg?Gln?Val?Val?Thr?Gly?Ser?Asp?Pro?Val?Ala
9305????????????????9310????????????????9315
Val?Val?Ala?Asp?Val?Asp?Pro?Asp?Arg?Phe?Val?Arg?Ala?Phe?Thr
9320????????????????9325????????????????9330
Thr?Val?Arg?Pro?Ser?Ser?Leu?Leu?Ala?Glu?Met?Pro?Ala?Tyr?Ala
9335????????????????9340????????????????9345
Ala?Leu?Lys?Lys?Ala?Ala?Ser?Ala?Gly?Gly?Glu?Ala?Ala?Asp?Ser
9350????????????????9355????????????????9360
Gly?Pro?Ser?Leu?Arg?Asp?Arg?Leu?Ala?Arg?Leu?Pro?Glu?Ser?Arg
9365????????????????9370????????????????9375
Arg?Thr?Gln?Thr?Val?Leu?Thr?Leu?Val?Arg?Glu?Arg?Ala?Ala?Glu
9380????????????????9385????????????????9390
Val?Leu?Gly?Leu?Thr?Gly?Thr?Asp?Gln?Val?Gly?Pro?Asp?Arg?Ala
9395????????????????9400????????????????9405
Phe?Arg?Asp?Leu?Gly?Phe?Asp?Ser?Leu?Gly?Ala?Val?Glu?Leu?Arg
9410????????????????9415????????????????9420
Asn?Gln?Leu?Gly?Ala?Val?Ser?Gly?Leu?Thr?Leu?Ser?Ala?Thr?Leu
9425????????????????9430????????????????9435
Val?Phe?Asp?His?Pro?Thr?Pro?Ala?Ala?Leu?Ala?Ala?His?Ile?Leu
9440????????????????9445????????????????9450
Gly?Gln?Leu?Leu?Pro?Ala?Gly?Thr?Pro?Gly?Ala?Pro?Ala?Thr?Asp
9455????????????????9460????????????????9465
Gly?Ala?Gly?Glu?Glu?Glu?Arg?Ala?Val?Arg?Ala?Ala?Leu?Ala?Gln
9470????????????????9475????????????????9480
Val?Pro?Leu?Asp?Arg?Leu?Arg?Asp?Ser?Gly?Leu?Leu?Asp?Gln?Leu
9485????????????????9490????????????????9495
Leu?Asp?Leu?Ala?Gly?Gln?Asp?Pro?Ala?Gly?Thr?Gly?Thr?Asp?Gln
9500????????????????9505????????????????9510
Glu?Ala?Glu?Pro?Ser?Gly?Ala?Gly?Asp?Ala?Tyr?Asp?Ala?Ser?Ile
9515????????????????9520????????????????9525
Asp?Ala?Met?Asp?Val?Asp?Gly?Leu?Val?Gln?Ala?Ala?Leu?Asn?Gly
9530????????????????9535????????????????9540
Asn?Pro?Asp?Glu?Glu?Arg?Asp
9545????????????????9550
<210>8
<211>335
<212>PRT
＜213〉streptomycete FR-008
<400>8
Met?Asn?Gly?Leu?His?Leu?Pro?Pro?Ala?Pro?Leu?Pro?Ala?Pro?Gly?Val
1???????????????5???????????????????10??????????????????15
Ser?Ala?Ala?Gly?Ser?Gly?Asp?Leu?Met?Ile?Glu?Ala?Glu?Gly?Val?Ser
20??????????????????25??????????????????30
Lys?Ala?Tyr?Gly?Thr?Val?His?Ala?Leu?Asp?Ser?Val?Ser?Leu?Ala?Val
35??????????????????40??????????????????45
Pro?Arg?Gly?Thr?Val?Leu?Gly?Leu?Leu?Gly?His?Asn?Gly?Ala?Gly?Lys
50??????????????????55??????????????????60
Thr?Thr?Leu?Val?Asp?Ile?Leu?Thr?Thr?Ala?Leu?Pro?Pro?Thr?Ser?Gly
65??????????????????70??????????????????75??????????????????80
Arg?Ala?Arg?Val?Ala?Gly?Tyr?Asp?Val?Ala?Asp?Lys?Pro?Val?Glu?Ile
85??????????????????90??????????????????95
Arg?Arg?Arg?Ile?Gly?Leu?Thr?Gly?Gln?Phe?Ala?Ser?Val?Asp?Ala?Gln
100?????????????????105?????????????????110
Leu?Ser?Gly?Tyr?Asp?Asn?Leu?Val?Leu?Ile?Ala?Arg?Leu?Leu?Gly?Ala
115?????????????????120?????????????????125
Gly?Arg?Arg?Ala?Ala?Arg?Val?Arg?Ala?Arg?Glu?Leu?Leu?Glu?Leu?Phe
130?????????????????135?????????????????140
Arg?Leu?Thr?Glu?Val?Ala?Asp?Arg?Arg?Ala?Ser?Ser?Tyr?Ser?Gly?Gly
145?????????????????150?????????????????155?????????????????160
Leu?Arg?Arg?Arg?Leu?Asp?Leu?Ala?Val?Ser?Leu?Val?Gly?Ala?Pro?Glu
165?????????????????170?????????????????175
Val?Leu?Phe?Leu?Asp?Glu?Pro?Thr?Thr?Gly?Leu?Asp?Pro?Ser?Ser?Arg
180?????????????????185?????????????????190
Ile?Asn?Leu?Trp?Glu?Ile?Val?Glu?Gly?Leu?Val?Glu?Gln?Gly?Thr?Thr
195?????????????????200?????????????????205
Val?Leu?Leu?Thr?Thr?Gln?Tyr?Leu?Glu?Glu?Ala?Asp?Arg?Leu?Ala?Asp
210?????????????????215?????????????????220
Arg?Ile?Ala?Val?Leu?Ser?Ala?Gly?Arg?Val?Val?Ala?Ala?Gly?Thr?Ala
225?????????????????230?????????????????235?????????????????240
Pro?Glu?Leu?Lys?Ala?Thr?Val?Gly?Arg?Arg?Thr?Val?Thr?Leu?Thr?Leu
245?????????????????250?????????????????255
Glu?Thr?Gly?Glu?Asp?Val?Ser?Ala?Ala?Arg?Thr?Ala?Leu?Arg?Gly?Ala
260?????????????????265?????????????????270
Gly?Phe?Ala?Pro?Val?Asp?Gly?Glu?Ala?Arg?Thr?Val?Val?Val?Pro?Ile
275?????????????????280?????????????????285
Asp?Ala?Thr?Arg?Glu?Ile?Ala?Asp?Ile?Ile?Arg?Ser?Leu?Asp?Gln?Ala
290?????????????????295?????????????????300
Gly?Val?Glu?Ala?Ser?Glu?Leu?Asn?Phe?Gly?Glu?ProThr?Leu?Asp?Asp
305?????????????????310?????????????????315????????????????320
Val?Tyr?Leu?Thr?Leu?Ala?Glu?Gln?Ala?Ala?Gly?Arg?Thr?Arg?Ala
325?????????????????330?????????????????335
<210>9
<211>239
<212>PRT
＜213〉streptomycete FR-008
<400>9
Met?Val?Thr?Asp?Pro?Gly?Ile?Val?Leu?Phe?Gly?Leu?Ile?Gln?Pro?Val
1???????????????5???????????????????10??????????????????15
Val?Ile?Leu?Phe?Val?Leu?Thr?Gln?Val?Phe?Ser?Lys?Met?Gly?Met?Pro
20??????????????????25??????????????????30
Pro?His?Phe?Pro?Asp?Gly?Val?Ser?Tyr?Leu?Asp?Tyr?Val?Leu?Pro?Ala
35??????????????????40??????????????????45
Val?Leu?Val?Asp?Asn?Ala?Ala?Gln?Ser?Ala?Met?Gln?Ser?Gly?Val?Gly
50??????????????????55??????????????????60
Leu?Val?Glu?Asp?Gln?Lys?Asn?Gly?Ile?Val?Ala?Arg?Leu?Arg?Ser?Leu
65??????????????????70??????????????????75??????????????????80
Pro?Val?His?Pro?Gly?Ala?Leu?Leu?Ala?Ala?Arg?Ser?Leu?Val?Gly?Leu
85??????????????????90??????????????????95
Val?Arg?Ser?Ala?Val?Gln?Val?Ala?Val?Ile?Met?Ala?Leu?Ala?Met?Thr
100?????????????????105?????????????????110
Val?Leu?Gly?Tyr?Ser?Pro?Asn?Gly?Gly?Ala?Ala?Glu?Leu?Ala?Leu?Ser
115?????????????????120?????????????????125
Ala?Gly?Leu?Thr?Leu?Phe?Ile?Ser?Phe?Ser?Leu?Gly?Trp?Ala?Phe?Ile
130?????????????????135?????????????????140
Ala?Ala?Gly?Ala?Trp?Leu?Arg?Arg?Ala?Glu?Pro?Leu?Gln?Asn?Leu?Ala
145?????????????????150?????????????????155?????????????????160
Leu?Ile?Val?Ile?Phe?Pro?Leu?Met?Phe?Ala?Ser?Ser?Ala?Tyr?Val?Pro
165?????????????????170?????????????????175
Val?Ala?Asp?Leu?Pro?Ser?Trp?Leu?Gly?Ala?Val?Ala?Ser?Val?Asn?Pro
180?????????????????185?????????????????190
Leu?Thr?Tyr?Ala?Ile?Asp?Ala?Thr?Arg?Ala?Leu?Ala?Leu?Asp?Val?Pro
195?????????????????200?????????????????205
Gly?Leu?Asp?His?Ala?Ile?Pro?Ala?Val?Val?Ile?Cys?Ala?Val?Ile?Ala
210?????????????????215?????????????????220
Val?Val?Gly?Met?Ile?Ala?Ala?Val?Arg?Gly?Phe?Arg?Arg?Pro?Leu
225?????????????????230?????????????????235
<210>10
<211>222
<212>PRT
＜213〉streptomycete FR-008
<400>10
Met?Asp?Pro?Ala?Pro?Ala?Ala?Asp?Pro?Ala?Gly?Ser?Pro?Glu?Arg?Ala
1???????????????5???????????????????10??????????????????15
Ala?Val?Leu?Ala?Asp?Gly?Phe?Asp?Arg?Ala?Gly?Ala?Tyr?Val?Ala?Cys
20??????????????????25??????????????????30
Leu?Asp?Pro?Ser?Leu?Thr?Ile?Gln?Gln?Val?Asn?Gln?Glu?Phe?Glu?Arg
35??????????????????40??????????????????45
Arg?Phe?Gly?Gly?Ser?Ser?Ser?Glu?Leu?Cys?Gly?Ser?Arg?Phe?Cys?Asp
50??????????????????55??????????????????60
Leu?Val?His?Pro?Ser?Val?Gln?Gln?Pro?Leu?Met?His?Gln?Phe?Ala?Arg
65??????????????????70??????????????????75??????????????????80
Met?Leu?Asp?Gly?Lys?Arg?His?Arg?Phe?Ala?Thr?Glu?Val?Ile?Ala?Val
85??????????????????90??????????????????95
Asp?Gln?Glu?Arg?Thr?Ala?Ser?Thr?Leu?Pro?Leu?Asn?Ala?Leu?Ala?Val
100?????????????????105?????????????????110
Arg?Gly?Gly?Arg?Thr?Pro?Asp?Val?Ala?Ala?Ile?Leu?Val?Val?Met?Asn
115?????????????????120?????????????????125
Ala?Ala?Glu?Glu?Glu?Ala?Gly?Asp?Ala?Asp?Val?Met?Ala?Pro?Arg?Lys
130?????????????????135?????????????????140
Lys?Leu?Leu?Ser?Glu?Ile?Asp?Ala?Arg?Ile?Leu?Glu?Gly?Ile?Ala?Ala
145?????????????????150?????????????????155?????????????????160
Gly?Val?Ser?Thr?Ile?Pro?Leu?Ala?Ser?Arg?Leu?Tyr?Leu?Ser?Arg?Gln
165?????????????????170?????????????????175
Gly?Val?Glu?Tyr?His?Val?Thr?Gly?Leu?Leu?Arg?Lys?Leu?Lys?Val?Pro
180?????????????????185?????????????????190
Asn?Arg?Ala?Ala?Leu?Val?Ser?Arg?Ala?Tyr?Ser?Met?Gly?Val?Leu?Lys
195?????????????????200?????????????????205
Val?Gly?Thr?Trp?Pro?Pro?Lys?Val?Val?Glu?Asp?Phe?Ile?Lys
210?????????????????215?????????????????220
<210>11
<211>942
<212>PRT
＜213〉streptomycete FR-008
<400>11
Met?Leu?Leu?Glu?Arg?Thr?Thr?Glu?Ile?Ala?Leu?Val?Asp?Ala?Ala?Leu
1???????????????5???????????????????10??????????????????15
Gly?Ala?Ala?Thr?Glu?Gly?Arg?Ser?Ser?Leu?Val?Leu?Leu?Thr?Gly?Pro
20??????????????????25??????????????????30
Leu?Gly?Ile?Gly?Arg?Ser?Ala?Leu?Leu?Gln?Arg?Leu?Ser?Cys?Leu?Ala
35??????????????????40??????????????????45
Asp?Asp?Arg?Asp?Asp?Val?Arg?Val?Leu?Arg?Ala?His?Ala?Ala?Pro?Met
50??????????????????55??????????????????60
Glu?Gln?Asp?Phe?Ala?Phe?Gly?Val?Val?Arg?Gln?Leu?Phe?Glu?Thr?Leu
65??????????????????70??????????????????75??????????????????80
Leu?Gly?Asp?Ser?Pro?Glu?Asp?Ala?Arg?Asp?Arg?Trp?Met?Asp?Ala?His
85??????????????????90??????????????????95
Ala?Ser?Phe?Ala?Arg?His?Val?Leu?Ala?Asp?Asp?Ala?Ala?Pro?Pro?Gly
100?????????????????105?????????????????110
Ala?Asp?Gln?Ala?Ile?Ala?Ala?Thr?Glu?Ala?Val?Leu?His?Gly?Leu?Leu
115?????????????????120?????????????????125
Ser?Leu?Leu?Ala?Asn?Val?Ser?Ala?Asp?Ser?Arg?Leu?Leu?Ile?Leu?Val
130?????????????????135?????????????????140
Asp?Asp?Leu?Gln?Trp?Ser?Asp?Val?Pro?Ser?Leu?Arg?Trp?Leu?Thr?Tyr
145?????????????????150?????????????????155?????????????????160
Leu?Ala?Lys?Arg?Leu?His?Gly?Leu?Arg?Ala?Val?Val?Val?Cys?Ala?Leu
165?????????????????170?????????????????175
Arg?Asp?Gly?Asp?Pro?Arg?Ser?His?His?Thr?Leu?Ala?Arg?Glu?Ile?Arg
180?????????????????185?????????????????190
Glu?Ala?Gly?Thr?Gln?Thr?Leu?Arg?Pro?Ala?Ser?Leu?Ser?Leu?Thr?Ala
195?????????????????200?????????????????205
Thr?His?Glu?Leu?Val?Arg?Glu?His?Phe?Gly?Glu?Ala?Gly?Asp?Asp?Glu
210?????????????????215?????????????????220
Phe?Val?Gln?Ala?Cys?His?Glu?Ala?Ser?Val?Gly?Asn?Pro?Leu?Phe?Leu
225?????????????????230?????????????????235?????????????????240
Leu?Ser?Ile?Leu?Val?Gly?Thr?Gly?Phe?Leu?Gly?Arg?Arg?Pro?Leu?Ala
245?????????????????250?????????????????255
Glu?His?Ala?Glu?Thr?Ala?Arg?Arg?Leu?Arg?Pro?Ser?Gln?Leu?Arg?Glu
260?????????????????265?????????????????270
Arg?Leu?Ala?Ser?Ile?Leu?Arg?Thr?Gln?Pro?Ala?Pro?Val?Arg?Asp?Leu
275?????????????????280?????????????????285
Ala?Ala?Ala?Ile?Ala?Ile?Leu?Gly?Glu?Gln?Ser?Asp?Ala?Pro?Thr?Leu
290?????????????????295?????????????????300
Ala?Arg?Leu?Ala?Gly?Leu?Asp?Ser?Ile?Gly?Tyr?Ala?Gly?Ala?Leu?Arg
305?????????????????310?????????????????315?????????????????320
Ala?Leu?Gly?Ala?Leu?Gly?Ala?Leu?Ala?Ala?Pro?Asp?Glu?Pro?Arg?Phe
325?????????????????330?????????????????335
Ile?His?Arg?Ser?Val?Arg?Asp?Ala?Ala?Glu?Ser?Thr?Leu?Thr?Met?Val
340?????????????????345?????????????????350
Gln?Arg?Glu?Arg?Met?His?Asp?Glu?Ala?Ala?Ala?Leu?Leu?Tyr?Ala?Ala
355?????????????????360?????????????????365
Gly?Ser?Pro?Ala?Glu?Gln?Val?Ala?Ala?Gln?Leu?Met?Ala?Val?Val?Thr
370?????????????????375?????????????????380
Arg?Arg?Gln?Pro?Trp?Ala?Val?Asp?Val?Leu?Arg?Ala?Ala?Ala?Asp?Thr
385?????????????????390?????????????????395?????????????????400
Ala?Leu?Arg?Arg?Gly?Ala?Pro?Asp?Thr?Ala?Ala?Gly?Tyr?Leu?Cys?Arg
405?????????????????410?????????????????415
Ala?Leu?Leu?Asp?Ser?Pro?Ala?Ala?Gly?Val?Gly?Arg?Gly?Arg?Leu?Leu
420?????????????????425?????????????????430
Val?Glu?Leu?Gly?Thr?Ala?Glu?Arg?Gly?Phe?Asp?Pro?Leu?Ala?Cys?Glu
435?????????????????440?????????????????445
Arg?His?Ile?Ala?Gln?Ala?Met?Thr?Leu?Leu?Pro?Glu?Pro?Arg?Asp?Arg
450?????????????????455?????????????????460
Ala?Val?Ala?Ala?Leu?Arg?Ile?Ser?Pro?Thr?Ala?Leu?Gly?Pro?Ala?Pro
465?????????????????470?????????????????475?????????????????480
Leu?Thr?Ala?Val?Asp?Leu?Leu?Arg?Gln?Ala?Ala?Glu?Asp?Leu?Gly?Pro
485?????????????????490?????????????????495
Ala?Asp?Gly?Leu?Thr?Gly?Thr?Asp?Arg?Asp?Leu?Ala?Leu?Arg?Leu?Glu
500?????????????????505?????????????????510
Ala?Arg?Leu?Arg?His?Cys?Gly?His?Glu?Asp?Pro?His?Glu?Leu?Ala?Ala
515?????????????????520?????????????????525
Ser?Ala?His?Arg?Leu?Lys?Glu?Leu?Gly?Pro?Glu?Pro?Pro?Val?Asp?Thr
530?????????????????535?????????????????540
Gly?Gly?Glu?Arg?Glu?Leu?Thr?Ile?Ala?Leu?Leu?Gly?Ala?Ala?Thr?Leu
545?????????????????550?????????????????555?????????????????560
Gly?Cys?His?Leu?Pro?Ala?Ser?Glu?Val?Val?Arg?Leu?Ala?Gly?Arg?Val
565?????????????????570?????????????????575
Leu?Asp?Arg?Glu?Pro?Ala?Thr?Ser?Ala?Arg?Ile?His?Ser?Thr?Leu?Pro
580?????????????????585?????????????????590
Leu?Ala?Ile?Ile?Thr?Met?Ile?Ala?Ala?Asp?Ser?Val?Glu?Ala?Val?Asp
595?????????????????600?????????????????605
Ser?Trp?Leu?Ala?Val?Glu?His?Arg?Ala?Asn?Glu?Arg?Gly?Thr?Thr?Pro
610?????????????????615?????????????????620
Ala?Asn?Ala?Leu?Val?His?Ile?Glu?Gln?Ala?Leu?Val?His?Leu?Gly?Arg
625?????????????????630?????????????????635?????????????????640
Gly?Arg?Leu?Ala?Gln?Ala?Arg?Glu?Gln?Ser?Glu?Thr?Ala?Leu?Gly?Met
645?????????????????650?????????????????655
Thr?Glu?Pro?Ala?His?Gln?Gly?Leu?Asp?Thr?Ala?Ala?Thr?Met?Thr?His
660?????????????????665?????????????????670
Ala?Ile?Val?Ala?Leu?Glu?Ser?Arg?Asp?Pro?Ser?Leu?Ala?Glu?Lys?Val
675?????????????????680?????????????????685
Leu?Arg?Arg?Ala?Ser?Arg?Ile?Arg?Pro?Gln?Gly?Leu?Thr?Leu?Thr?Gly
690?????????????????695?????????????????700
Ile?Leu?Arg?Leu?Leu?Glu?Ala?Thr?Arg?Glu?Ile?Ala?Ala?Gly?Asp?Gln
705?????????????????710?????????????????715?????????????????720
Thr?Gly?Ala?Leu?Asp?Ser?Leu?His?Ser?Cys?Gly?Arg?Gln?Leu?Glu?Ala
725?????????????????730?????????????????735
Ala?Gly?Trp?His?Asn?Pro?Val?Leu?Phe?Pro?Trp?Arg?Pro?Trp?Ala?Val
740?????????????????745?????????????????750
Gly?Val?His?Arg?Arg?Leu?Gly?Asp?Ile?Arg?Thr?Ala?Arg?Ser?Leu?Ala
755?????????????????760?????????????????765
Glu?Glu?Glu?Tyr?Ala?Arg?Ala?Glu?Gln?Trp?Gly?Ala?Pro?Val?Gly?Val
770?????????????????775?????????????????780
Gly?Arg?Ala?Leu?Arg?Leu?Leu?Gly?Arg?Leu?Glu?Asp?Gly?Gly?Arg?Gly
785?????????????????790?????????????????795?????????????????800
Ile?Gly?Leu?Leu?Arg?Glu?Ala?Val?Thr?Val?Leu?Arg?Gly?Ser?Ala?Asn
805?????????????????810?????????????????815
Gln?Leu?Glu?Leu?Ala?Arg?Ala?Leu?Ser?Thr?Leu?Ala?Glu?Arg?Leu?Gly
820?????????????????825?????????????????830
Gly?Gly?Ala?Glu?Thr?Glu?Ala?Leu?Ala?Arg?Glu?Ala?Ala?Thr?Leu?Ala
835?????????????????840?????????????????845
Thr?Ser?Cys?Gly?Ala?Pro?Gly?Leu?Ala?Glu?Arg?Ala?Ala?Arg?Gly?Ala
850?????????????????855?????????????????860
Gly?His?Arg?Ser?Gly?Pro?Pro?Ala?Thr?Pro?Glu?Asp?Val?Leu?Thr?Pro
865?????????????????870?????????????????875?????????????????880
Thr?Glu?Arg?Arg?Val?Val?Gly?Leu?Ala?Cys?Arg?Gly?Leu?Thr?Asn?Gln
885?????????????????890?????????????????895
Glu?Ile?Ala?Gly?Ala?Leu?Gly?Val?Ser?Ser?Arg?Ala?Val?Glu?Lys?His
900?????????????????905?????????????????910
Leu?Thr?His?Ala?Tyr?Arg?Arg?Leu?Gly?Ile?Ser?Gly?Arg?Arg?Glu?Leu
915?????????????????920?????????????????925
Ile?Val?Leu?Phe?Ser?Arg?Ala?Glu?Tyr?Ala?Gly?Thr?Gly?Asp
930?????????????????935?????????????????940
<210>12
<211>1036
<212>PRT
＜213〉streptomycete FR-008
<400>12
Met?Arg?Ser?Gly?Glu?Ile?His?Arg?Lys?Asn?Ser?Gly?Leu?Gln?Thr?Pro
1???????????????5???????????????????10??????????????????15
Thr?Cys?Cys?Thr?Ala?Gln?Met?Tyr?Asp?Leu?His?Met?Pro?Pro?Ile?Glu
20??????????????????25??????????????????30
Leu?Pro?Leu?Leu?Glu?Arg?Asp?Arg?Glu?Leu?Ala?Ala?Leu?Ser?Ala?Val
35??????????????????40??????????????????45
Ile?Gly?Glu?Leu?Gly?Ser?Gly?Arg?Pro?Ala?Val?Val?Thr?Val?Thr?Gly
50??????????????????55??????????????????60
Glu?Pro?Gly?Leu?Gly?Gln?Asn?Asp?Leu?Leu?Arg?Trp?Ala?Ala?Ala?Tyr
65??????????????????70??????????????????75??????????????????80
Ala?Thr?Asp?Ala?Gly?Leu?Arg?Val?Leu?Ser?Ala?His?Ala?Thr?Pro?Ala
85??????????????????90??????????????????95
Glu?His?Glu?Val?Arg?Tyr?Gly?Val?Val?Ala?Gln?Leu?Leu?Ala?Glu?Glu
100?????????????????105?????????????????110
Asn?Arg?Ala?Leu?Ala?Pro?Arg?Leu?Phe?Leu?Thr?Asp?Glu?Gln?Pro?Gly
115?????????????????120?????????????????125
Gly?Leu?Pro?Gly?Leu?Asn?Gly?Leu?Leu?Asn?Ala?Val?Arg?Asp?Arg?Pro
130?????????????????135?????????????????140
Thr?Leu?Leu?Val?Val?Arg?Asp?Thr?Gln?Trp?Leu?Asp?Pro?Ala?Ser?Leu
145?????????????????150?????????????????155?????????????????160
Arg?Trp?Leu?Glu?Ala?Leu?Ala?Arg?Arg?Leu?Pro?Arg?Ala?Pro?Val?Ala
165?????????????????170?????????????????175
Leu?Leu?Thr?Ser?Thr?Thr?Gly?Thr?Ala?Leu?Thr?Arg?Pro?Glu?Trp?Ser
180?????????????????185?????????????????190
Val?Gly?Thr?Pro?Leu?Thr?Gly?Leu?Ala?Thr?Thr?Ile?Glu?Leu?Ala?Leu
195?????????????????200?????????????????205
Pro?Pro?Leu?Thr?Ser?Gly?Gly?Thr?Ala?Thr?Ala?Val?Leu?Arg?Ala?Phe
210?????????????????215?????????????????220
Gly?Ala?Pro?Gly?Asp?Pro?Ala?Phe?Thr?Glu?Ala?Leu?Ala?Glu?Ala?Thr
225?????????????????230?????????????????235?????????????????240
Arg?Gly?Ile?Pro?Ala?Val?Val?His?Asp?Val?Leu?Asp?Arg?Phe?Ala?Arg
245?????????????????250?????????????????255
Ala?Gly?Tyr?Ser?Pro?Arg?Ala?Asp?Arg?Ile?Asp?Pro?Leu?Arg?Ala?Leu
260?????????????????265?????????????????270
Thr?Ala?Glu?Val?Val?Gly?Asp?His?Ala?Thr?Arg?Ala?Leu?Ser?Asp?Leu
275?????????????????280?????????????????285
Arg?Asp?Pro?Ala?Ala?Val?Asp?Ala?Leu?Arg?Ala?Leu?Ala?Val?Cys?Gly
290?????????????????295?????????????????300
Asp?Leu?Leu?Asp?Phe?Pro?Leu?Val?Cys?Thr?Leu?Ala?Gly?Pro?His?Ser
305?????????????????310?????????????????315?????????????????320
Val?Ser?Glu?Ser?Arg?Leu?Arg?Ala?Ala?Leu?Ala?Ala?Ser?Gly?Leu?Thr
325?????????????????330?????????????????335
Thr?Leu?Arg?Asp?Gly?His?Pro?Arg?Val?Gln?Asp?Ala?Val?Val?Arg?Ala
340?????????????????345?????????????????350
Arg?Val?Leu?Glu?Glu?Met?Pro?Ala?Ala?Asp?Arg?Ala?Glu?Leu?Tyr?Ala
355?????????????????360?????????????????365
Arg?Ala?Ala?Gly?Leu?Ala?Gln?Arg?Val?Ala?Ala?Asp?Asp?Gln?Gly?Ile
370?????????????????375?????????????????380
Ala?Asp?Leu?Leu?Leu?Leu?Ala?Arg?Pro?Val?Gly?Asp?Pro?Trp?Ala?Val
385?????????????????390?????????????????395?????????????????400
Asp?Thr?Leu?Arg?Arg?Gly?Phe?Thr?Ser?Ala?Leu?Arg?Gly?Gly?Arg?Arg
405?????????????????410?????????????????415
Asp?Leu?Ala?Val?Ala?Tyr?Leu?Ala?Arg?Ala?Leu?Asp?Glu?Pro?Leu?Ala
420?????????????????425?????????????????430
Ala?Glu?Asp?Arg?Ala?Arg?Ile?Glu?Phe?Gln?Leu?Ala?Ser?Val?Glu?Met
435?????????????????440?????????????????445
Val?Thr?Ala?Pro?Thr?Ala?Ala?Glu?Arg?Arg?Leu?Gly?Gly?Leu?Ile?Arg
450?????????????????455?????????????????460
Ala?Thr?Arg?Pro?Gly?Pro?Gly?Ala?Gly?Leu?Arg?Ala?Arg?Ala?Thr?Asp
465?????????????????470?????????????????475?????????????????480
Leu?Cys?Leu?Leu?Gly?Gly?Asp?Thr?Arg?Ala?Ala?Arg?His?Ala?Leu?Ala
485?????????????????490?????????????????495
Gly?Ala?Ile?Asp?Ser?Ala?Pro?Ala?Ala?Pro?Glu?Pro?Arg?Arg?Gly?Pro
500?????????????????505?????????????????510
Thr?Gly?Ala?Pro?Ala?Val?Pro?Pro?Glu?Ala?Glu?Pro?Ala?Ser?Thr?Pro
515?????????????????520?????????????????525
Arg?Thr?His?Leu?Val?Pro?His?Arg?Pro?Tyr?Ala?Gly?Thr?Pro?Pro?Gly
530?????????????????535?????????????????540
Ala?Thr?Gly?Pro?Asp?Gly?Arg?Arg?Ser?Ala?Ala?Pro?Asp?Leu?Pro?Gly
545?????????????????550?????????????????555?????????????????560
Thr?Pro?Arg?Ala?His?Asp?Ala?Pro?Arg?Ser?Pro?Gly?Pro?Glu?Ala?Ala
565?????????????????570?????????????????575
Gly?Arg?Pro?Asp?Thr?Ala?Gly?Pro?Asp?Glu?Asp?Pro?Ala?Val?Ala?Glu
580?????????????????585?????????????????590
Arg?His?Glu?Leu?Thr?Val?Leu?Cys?Arg?Val?Ala?Ser?Phe?Leu?Arg?His
595?????????????????600?????????????????605
Asp?Asp?Ala?Asp?Leu?Asp?Val?Leu?Pro?Val?Pro?Ala?Leu?Pro?Asp?Ala
610?????????????????615?????????????????620
Val?His?Asn?Pro?Ala?Val?Ala?Gly?Val?Trp?Ala?Trp?Glu?His?Gly?Val
625?????????????????630?????????????????635?????????????????640
Ala?Gly?Val?His?Arg?Glu?Glu?Val?Arg?Arg?Leu?Ala?Arg?Ser?Ala?Phe
645?????????????????650?????????????????655
Val?Pro?Ala?Ala?Thr?Gly?Arg?Pro?Leu?Leu?Val?Val?Pro?Arg?Leu?Leu
660?????????????????665?????????????????670
Gly?Cys?Arg?Ala?Leu?Leu?Leu?Thr?Asp?Asp?Gly?Asp?Glu?Ala?Glu?Asn
675?????????????????680?????????????????685
His?Leu?Gly?Ala?Leu?Leu?Asp?Glu?Ser?His?Arg?Glu?Arg?Ala?Ala?Ile
690?????????????????695?????????????????700
Ser?Val?Ala?His?Ile?Leu?Thr?Val?Arg?Ala?Glu?Leu?His?Ile?Arg?His
705?????????????????710?????????????????715?????????????????720
Gly?Arg?Pro?Asp?Ala?Ala?Ala?Arg?Asp?Leu?Ala?Ala?Ala?Gln?Ala?Glu
725?????????????????730?????????????????735
Leu?Pro?Leu?Asp?Arg?Leu?His?Pro?Leu?Phe?Leu?Pro?Tyr?Trp?Leu?Ala
740?????????????????745?????????????????750
Leu?Ser?Met?Ile?Thr?Asp?Leu?Gln?Asn?Gly?His?Thr?Glu?Arg?Ala?Arg
755?????????????????760?????????????????765
Glu?Thr?Ala?Ala?Arg?Pro?Leu?Pro?Pro?Leu?Ala?His?Glu?Ser?Ala?Thr
770?????????????????775?????????????????780
Thr?Ala?Gln?Leu?Leu?Phe?Ala?Arg?Gly?Val?Leu?Ala?Arg?Thr?Asp?Asp
785?????????????????790?????????????????795?????????????????800
Glu?Pro?His?Gln?Ala?Arg?Glu?His?Phe?Arg?Ala?Cys?Gly?Arg?Trp?Leu
805?????????????????810?????????????????815
Leu?Arg?His?Gly?Cys?Ala?Asn?Pro?Ala?Val?Gln?Pro?Trp?Arg?Ser?Leu
820?????????????????825?????????????????830
Ala?Ala?Glu?Ala?Ala?His?Thr?Leu?Gly?Asp?Thr?Glu?Glu?Ala?Ala?Arg
835?????????????????840?????????????????845
Leu?Val?His?Glu?Glu?Val?Arg?Leu?Ala?Arg?Arg?Trp?Gly?Ala?Ala?Ala
850?????????????????855?????????????????860
Pro?Leu?Gly?Arg?Ala?Gln?Leu?Ser?Leu?Ala?Val?Val?Thr?Glu?Glu?Asn
865?????????????????870?????????????????875?????????????????880
Arg?Val?Glu?Asn?Leu?Arg?Ala?Ala?Val?Thr?Thr?Leu?Ser?Ala?Ala?Ser
885?????????????????890?????????????????895
Ala?Arg?Thr?Ala?Tyr?Thr?Arg?Ala?Val?Ile?Glu?Leu?Ala?Ala?Ala?Glu
900?????????????????905?????????????????910
Arg?Glu?Glu?Asn?Glu?Arg?Arg?Thr?Ala?Val?Ala?Leu?Gly?Pro?Ala?Ala
915?????????????????920?????????????????925
Thr?Val?Leu?Pro?Pro?Val?Ala?Pro?Pro?Pro?Gly?Pro?His?Val?Pro?Ser
930?????????????????935?????????????????940
Ala?Val?Ala?Arg?Pro?Pro?Gly?Pro?Arg?Pro?Ala?Val?Leu?Thr?Gly?Arg
945?????????????????950?????????????????955?????????????????960
Arg?Thr?Ala?Lys?Ala?Pro?Gly?His?Asp?Ala?Ala?Val?Trp?His?Gly?Leu
965?????????????????970?????????????????975
Thr?Ala?Val?Glu?Arg?Glu?Thr?Ala?Ala?Leu?Ala?Ala?Gln?Gly?Leu?Gly
980?????????????????985?????????????????990
Asn?Arg?Glu?Ile?Ala?Thr?Glu?Leu?Ala?Val?Thr?Thr?Arg?Ala?Val?Glu
995?????????????????1000????????????????1005
Leu?Arg?Leu?Ser?Gly?Val?Tyr?Arg?Lys?Leu?Arg?Ile?Arg?Gly?Arg
1010????????????????1015????????????????1020
Glu?Glu?Leu?Arg?Ala?Leu?Val?Gln?Glu?Ala?Glu?Gly?Ser
1025????????????????1030????????????????1035
<210>13
<211>1005
<212>PRT
＜213〉streptomycete FR-008
<400>13
Met?Trp?Leu?Arg?Trp?Ala?Gly?Asp?Arg?Ser?Arg?Gly?Ala?Ala?Pro?Gly
1???????????????5???????????????????10??????????????????15
Arg?Ser?Gly?Ser?Ala?Gly?Pro?Pro?Ser?Leu?Ala?Pro?Ser?Asp?Ala?Arg
20??????????????????25??????????????????30
Glu?Ser?Pro?Val?Pro?His?Arg?Ser?Arg?Ala?Val?Pro?Pro?Ala?Pro?Pro
35??????????????????40??????????????????45
Leu?Val?Gly?Arg?Ala?His?Gln?Leu?Asp?Val?Leu?Ala?Arg?His?Ala?Asp
50??????????????????55??????????????????60
Ala?Ala?Arg?Ala?Gly?Arg?Pro?Arg?Leu?Val?Leu?Leu?Asp?Gly?Pro?Ala
65??????????????????70??????????????????75??????????????????80
Gly?Ile?Gly?Lys?Thr?Ala?Leu?Leu?Arg?Ala?Ala?Leu?Ala?Glu?Asp?Gly
85??????????????????90??????????????????95
Pro?Leu?Ala?Gly?Met?Thr?Thr?Leu?Tyr?Gly?Ser?Cys?Arg?Ala?Val?Asp
100?????????????????105?????????????????110
Val?Ala?Thr?Gly?Tyr?Ser?Gly?Val?Arg?Ala?Leu?Phe?Gly?Gly?Leu?Gly
115?????????????????120?????????????????125
Leu?Thr?Gly?Arg?Lys?Gly?Arg?Thr?Ser?Pro?Leu?Leu?Val?Gly?Gly?Ala
130?????????????????135?????????????????140
Arg?Arg?Ala?Leu?Pro?Ala?Leu?Ala?Ala?Asp?Pro?Gly?Glu?Leu?Asp?Ala
145?????????????????150?????????????????155?????????????????160
Asp?Pro?Gly?Ser?Thr?Phe?Ser?Val?Leu?Gln?Gly?Leu?Tyr?Trp?Leu?Ala
165?????????????????170?????????????????175
Ala?Asn?Leu?Met?Ala?Asp?Gly?Pro?Leu?Val?Leu?Val?Leu?Asp?Asp?Val
180?????????????????185?????????????????190
His?Trp?Cys?Asp?Glu?Arg?Ser?Leu?Arg?Trp?Leu?Asp?Phe?Leu?Leu?Arg
195?????????????????200?????????????????205
Arg?Ala?Asp?Gly?Leu?Pro?Leu?Leu?Val?Val?Ala?Ala?His?Arg?Thr?Gly
210?????????????????215?????????????????220
Thr?Gly?Leu?Thr?Ala?Pro?Asp?Ala?Leu?Ala?Asp?Leu?Val?Ala?His?His
225?????????????????230?????????????????235?????????????????240
Leu?Pro?Ala?Ser?Leu?Gly?Leu?Gly?Pro?Leu?Asp?Thr?Ala?Glu?Val?Ala
245?????????????????250?????????????????255
Glu?Leu?Thr?Ala?His?Ser?Phe?Pro?Glu?Gln?Asp?Pro?Leu?Pro?Ser?Phe
260?????????????????265?????????????????270
Val?Gly?Arg?Leu?Leu?Ser?Val?Thr?Gly?Gly?Ser?Pro?Leu?Glu?Ile?Val
275?????????????????280?????????????????285
Arg?Leu?Leu?Arg?Asp?Leu?Arg?Ser?Ala?Gly?Leu?Gly?Pro?Asp?Asp?Thr
290?????????????????295?????????????????300
Gly?Thr?Ala?Arg?Leu?Ala?Gln?Ala?Gly?Gly?Lys?Val?Val?Ala?Ala?Ser
305?????????????????310?????????????????315?????????????????320
Val?Arg?Gly?Val?Leu?Glu?His?Gln?Pro?Asp?Trp?Val?Arg?Gln?Val?Ala
325?????????????????330?????????????????335
Arg?Ala?Val?Ala?Val?Leu?Gly?Asp?Glu?Asp?Arg?Thr?Tyr?Leu?Ala?Ala
340?????????????????345?????????????????350
Leu?Gly?Arg?Val?Ser?Val?Val?His?Val?Glu?Glu?Ala?Val?Glu?Ile?Leu
355?????????????????360?????????????????365
Arg?Asp?Ala?Gly?Leu?Ile?His?Pro?Gly?His?Leu?Glu?Leu?Ser?His?Asp
370?????????????????375?????????????????380
Leu?Val?Arg?Ala?Ala?Val?Leu?Asp?Ala?Val?Gly?Ala?Ser?Gly?Val?Ala
385?????????????????390?????????????????395?????????????????400
Val?Leu?Arg?Arg?Arg?Ala?Ala?Arg?Leu?Leu?Ser?Asp?Val?Gly?Arg?Ser
405?????????????????410?????????????????415
Pro?Glu?Glu?Ile?Ala?Thr?Gln?Leu?Leu?Leu?Val?Pro?Gly?Thr?Pro?Asp
420?????????????????425?????????????????430
Asp?Trp?Ala?Val?Ser?Val?Leu?Arg?Asp?Ala?Ala?Ala?Gln?Ala?Glu?Gln
435?????????????????440?????????????????445
Arg?Gly?Ala?Cys?Glu?Ala?Ala?Ala?Arg?Tyr?Leu?Glu?Arg?Val?Arg?Glu
450?????????????????455?????????????????460
Ala?Glu?Pro?Lys?Asp?Pro?Asp?Val?Leu?Ser?Arg?Leu?Gly?Lys?Ala?Leu
465?????????????????470?????????????????475?????????????????480
Ala?Glu?Thr?Asp?Pro?Ala?Arg?Ser?Val?Thr?Leu?Leu?His?Glu?Ala?His
485?????????????????490?????????????????495
Ser?Leu?Thr?Thr?Asp?Val?Arg?Ala?Arg?Ala?Ala?Thr?Ala?Val?Gln?Leu
500?????????????????505?????????????????510
Gly?Leu?Thr?Cys?Leu?Ala?Val?Gln?Gln?Ser?Pro?Asp?Gly?Ala?Arg?Ala
515?????????????????520?????????????????525
Leu?Thr?Glu?Ala?Leu?Asp?Ala?Leu?Asp?Ala?Glu?Leu?Gly?Pro?Glu?Pro
530?????????????????535?????????????????540
Glu?Pro?Ala?Asp?Arg?Glu?Leu?Arg?Thr?Leu?Thr?Glu?Ser?Ala?Leu?Leu
545?????????????????550?????????????????555????????????????560
Ile?Val?Gly?Ser?Asp?Glu?Lys?Ala?Thr?Leu?Pro?Asp?Ile?Leu?Arg?Arg
565?????????????????570?????????????????575
Thr?Glu?Gly?Leu?Thr?Pro?Gln?Pro?Gly?Asp?Thr?Pro?Ala?Gln?Arg?Gln
580?????????????????585?????????????????590
Gln?Leu?Ala?Met?Leu?Ser?Val?Leu?Ser?Ala?Ala?Glu?Gly?Gly?Gly?Ala
595?????????????????600?????????????????605
Glu?Glu?Thr?Val?Gly?Arg?Ala?Arg?Arg?Ala?Leu?Arg?Ala?Pro?Gly?Val
6l0?????????????????6l5?????????????????620
Pro?Leu?Gly?Val?Trp?Ser?Leu?Leu?Pro?Thr?Ser?Leu?Ala?Leu?Ser?Leu
625?????????????????630?????????????????635?????????????????640
Ala?Asp?Glu?Asn?Glu?Ala?Ala?Glu?Glu?Val?Leu?Glu?Thr?Val?Leu?Arg
645?????????????????650?????????????????655
Gly?Ser?Gly?Asp?Thr?Ala?Ala?Val?Trp?Thr?Tyr?Val?Leu?Ala?Leu?Ser
660?????????????????665?????????????????670
Thr?Arg?Ser?Leu?Phe?Arg?Leu?Glu?Asn?Gly?Ala?Val?Pro?Asp?Ala?Met
675?????????????????680?????????????????685
Ala?Asp?Ala?Gln?Thr?Ala?Leu?Glu?Ile?Leu?Gly?Gln?Glu?Arg?Trp?Gly
690?????????????????695?????????????????700
Asp?Thr?Ala?Thr?Met?Pro?His?Thr?Ala?Tyr?Ala?Ser?Val?Leu?Thr?Glu
705?????????????????710?????????????????715?????????????????720
Arg?Gly?Asp?Pro?Gly?Arg?Ala?Leu?Glu?Ala?Leu?Asp?Ala?Ile?Lys?Arg
725?????????????????730?????????????????735
Pro?His?Leu?Asp?Arg?Phe?Val?Trp?Glu?Tyr?His?Trp?Tyr?Leu?Met?Ala
740?????????????????745?????????????????750
Arg?Gly?Arg?Ala?Leu?Ala?Ala?Asp?Gly?Asp?Leu?Asp?Gly?Ala?Leu?Gln
755?????????????????760?????????????????765
Val?Phe?Gly?Ser?Cys?Gly?Ala?Ser?Met?Ala?Glu?Ala?Gly?Leu?Thr?Asn
770?????????????????775?????????????????780
Pro?Val?Leu?Ala?Pro?Trp?Trp?Leu?Glu?Thr?Ala?Cys?Leu?Leu?Gly?Glu
785?????????????????790?????????????????795?????????????????800
Ala?Gly?Arg?Gly?Glu?Glu?Ala?Gly?Arg?Ala?Ala?Ala?His?Gly?Thr?Arg
805?????????????????810?????????????????815
Leu?Ala?Glu?Arg?Trp?Gly?Thr?Arg?Arg?Ala?Leu?Gly?Tyr?Ala?Ala?Leu
820?????????????????825?????????????????830
Ala?Arg?Gly?Ala?Ala?Ala?Arg?Gly?Thr?Ala?Arg?Thr?Gly?Ala?Leu?Arg
835?????????????????840?????????????????845
Glu?Ala?Val?Ala?Leu?Leu?Ala?Asp?Ser?Pro?Ala?Arg?Ser?Gly?His?Ala
850?????????????????855?????????????????860
Arg?Gly?Leu?Leu?Leu?Leu?Gly?Arg?Ala?Leu?Val?Glu?Asp?Gly?Ala?Val
865?????????????????870?????????????????875?????????????????880
Arg?Glu?Gly?Arg?Glu?His?Leu?Arg?Glu?Ala?Val?Gly?Leu?Ala?Arg?Arg
885?????????????????890?????????????????895
Cys?Gly?Cys?Val?Ala?Leu?Ala?Arg?Arg?Ala?Arg?Asp?Glu?Leu?Ile?Ala
900?????????????????905?????????????????910
Ala?Gly?Gly?Arg?Met?Arg?Glu?Val?Thr?Ala?Ser?Pro?Leu?Asp?Met?Leu
915?????????????????920?????????????????925
Thr?Gly?Thr?Glu?Arg?Thr?Val?Ala?Gly?Leu?Val?Ala?Ser?Gly?Ala?Gly
930?????????????????935?????????????????940
Asn?Arg?Glu?Val?Ala?Glu?Ser?Leu?Phe?Val?Thr?Val?Arg?Thr?Val?Glu
945?????????????????950?????????????????955?????????????????960
Leu?His?Leu?Thr?Ser?Val?Tyr?Arg?Lys?Leu?Gly?Val?Ala?Arg?Arg?Gly
965?????????????????970?????????????????975
Asp?Leu?Thr?Glu?Ala?Leu?Arg?Glu?Ala?Gly?Ala?Thr?Ala?Arg?Pro?Ala
980?????????????????985?????????????????990
Ala?Glu?Arg?Arg?Pro?Gly?His?Ala?Lys?Arg?Arg?Asn?Pro
995?????????????????1000????????????????1005
<210>14
<211>393
<212>PRT
＜213〉streptomycete FR-008
<400>14
Met?Thr?Thr?Ser?Pro?Gly?Pro?Thr?Val?Val?Asp?Phe?Pro?Arg?Arg?Thr
1???????????????5???????????????????10??????????????????15
Pro?Arg?Glu?Pro?Leu?Pro?Leu?Ser?Gln?Tyr?Ala?Glu?His?Arg?Lys?Gln
20??????????????????25??????????????????30
Asn?Gly?Leu?Val?Gln?Thr?His?Leu?Pro?Asn?Gly?Arg?Pro?Ile?Trp?Leu
35??????????????????40??????????????????45
Val?Thr?Arg?His?Glu?Asp?Val?Arg?Ala?Val?Leu?Thr?His?Pro?Arg?Ile
50??????????????????55??????????????????60
Ser?Ala?Asn?Pro?Asp?Asn?Glu?Gly?Phe?Pro?Asn?Val?Gly?Glu?Thr?Met
65??????????????????70??????????????????75??????????????????80
Gly?Val?Pro?Lys?Gln?Glu?Gln?Ile?Pro?Gly?Trp?Phe?Val?Gly?Leu?Asp
85??????????????????90??????????????????95
Ser?Pro?Glu?His?Asp?Arg?Phe?Arg?Lys?Val?Leu?Ile?Pro?Glu?Phe?Thr
100?????????????????105?????????????????110
Val?Arg?Arg?Val?Arg?Glu?Leu?Arg?Pro?Ala?Ile?Glu?Arg?Thr?Val?Asp
115?????????????????120?????????????????125
Glu?Arg?Ile?Asp?Ala?Met?Leu?Ala?Gly?Gly?Asn?Thr?Ala?Asp?Leu?Val
130?????????????????135?????????????????140
Asn?Asp?Phe?Ala?Leu?Pro?Val?Pro?Ser?Leu?Val?Ile?Ser?Ala?Leu?Leu
145?????????????????150?????????????????155?????????????????160
Gly?Val?Pro?Ser?Ala?Asp?Arg?Asp?Phe?Phe?Glu?Ser?Arg?Thr?Arg?Thr
165?????????????????170?????????????????175
Leu?Val?Ala?Ile?Arg?Thr?Ser?Thr?Asp?Glu?Glu?Arg?Ala?Glu?Ala?Thr
180?????????????????185?????????????????190
Arg?Gln?Leu?Leu?Arg?Tyr?Ile?Asn?Arg?Leu?Ile?Val?Ile?Lys?Lys?Lys
195?????????????????200?????????????????205
Trp?Arg?Gly?Glu?Asp?Leu?Ile?Ser?Arg?Leu?Leu?Ser?Thr?Gly?Lys?Leu
210?????????????????215?????????????????220
Ser?Asp?Glu?Glu?Leu?Ser?Gly?Val?Leu?Leu?Leu?Leu?Leu?Ile?Ala?Gly
225?????????????????230?????????????????235?????????????????240
His?Glu?Thr?Thr?Ala?Asn?Asn?Ile?Gly?Leu?Gly?Val?Val?Thr?Leu?Leu
245?????????????????250?????????????????255
Ser?His?Arg?Glu?Trp?Ile?Gly?Asp?Asp?Arg?Leu?Val?Glu?Glu?Leu?Leu
260?????????????????265?????????????????270
Arg?Leu?His?Ser?Val?Ala?Asp?Met?Val?Ala?Leu?Arg?Val?Ala?Val?Asp
275?????????????????280?????????????????285
Asp?Val?Glu?Ile?Ala?Gly?Gln?Thr?Ile?Arg?Lys?Gly?Glu?Gly?Ile?Val
290?????????????????295?????????????????300
Pro?Leu?Leu?Ala?Ser?Ala?Asn?His?Asp?Thr?Glu?Ala?Phe?Gly?Cys?Pro
305?????????????????310?????????????????315?????????????????320
His?Ala?Phe?Asn?Pro?Glu?Arg?Thr?Glu?Arg?Arg?His?Val?Ala?Phe?Gly
325?????????????????330?????????????????335
Tyr?Gly?Val?His?Gln?Cys?Leu?Gly?Gln?Asn?Leu?Val?Arg?Val?Glu?Met
340?????????????????345?????????????????350
Glu?Ile?Ala?Tyr?Arg?Lys?Leu?Phe?Glu?Arg?Ile?Pro?Glu?Leu?Arg?Leu
355?????????????????360?????????????????365
Ala?Val?Pro?Glu?Asp?Gln?Leu?Ala?Tyr?Lys?Tyr?Asp?Gly?Ile?Leu?Phe
370?????????????????375?????????????????380
Gly?Leu?His?Glu?Leu?Pro?Val?Arg?Trp
385?????????????????390
<210>15
<211>64
<212>PRT
＜213〉streptomycete FR-008
<400>15
Met?Arg?Val?Thr?Val?Asp?Ser?Glu?Gln?Cys?Val?Gly?Ala?Gly?Gln?Cys
1???????????????5???????????????????10??????????????????15
Val?Leu?Asn?Ala?Pro?Glu?Val?Phe?Asp?Gln?Asp?Asp?Asp?Gly?Val?Val
20??????????????????25??????????????????30
Val?Leu?Leu?Arg?Ala?Glu?Pro?Asp?Glu?Arg?Asp?His?Glu?Ala?Val?Arg
35??????????????????40??????????????????45
Thr?Ala?Gly?Asp?Leu?Cys?Pro?Ser?Ala?Ser?Val?Val?Leu?Gln?Glu?Asp
50??????????????????55??????????????????60
<210>16
<211>285
<212>PRT
＜213〉streptomycete FR-008
<400>16
Met?Pro?Arg?Pro?Ala?Arg?Pro?Ser?His?Pro?Arg?Thr?Arg?Arg?Arg?Arg
1???????????????5???????????????????10??????????????????15
Asn?Thr?Asp?Arg?Arg?Gln?Asn?His?Arg?Arg?Asp?Ser?Pro?Val?Thr?Thr
20??????????????????25??????????????????30
Ala?Asp?Asp?Thr?Ala?Ala?Arg?Trp?Leu?Arg?Arg?Tyr?His?Pro?Ala?Glu
35??????????????????40??????????????????45
Ala?Asp?Ala?Val?Arg?Leu?Val?Cys?Phe?Pro?His?Ala?Gly?Gly?Ser?Ala
50??????????????????55??????????????????60
Ser?Phe?Tyr?His?Pro?Val?Ser?Ala?Arg?Phe?Ala?Pro?Gly?Ala?Glu?Val
65??????????????????70??????????????????75??????????????????80
Val?Ser?Leu?Gln?Tyr?Pro?Gly?Arg?Gln?Asp?Arg?Arg?Lys?Glu?Pro?Cys
85??????????????????90??????????????????95
Val?Pro?Asp?Leu?Gly?Thr?Leu?Ala?Asp?Leu?Ile?Thr?Glu?Gln?Leu?Leu
100?????????????????105?????????????????110
Pro?Leu?Asp?Glu?Arg?Pro?Thr?Val?Phe?Phe?Gly?His?Ser?Met?Gly?Ala
115?????????????????120?????????????????125
Ala?Leu?Ala?Phe?Glu?Thr?Ala?Trp?Arg?Leu?Glu?Gln?Lys?Gly?Ala?Gly
130?????????????????135?????????????????140
Pro?Arg?Thr?Val?Ile?Ala?Ser?Gly?Arg?Arg?Gly?Pro?Ser?Thr?Thr?Arg
145?????????????????150?????????????????155?????????????????160
Ala?Glu?Arg?Val?His?Thr?Arg?Asp?Asp?Asp?Gly?Ile?Val?Ala?Glu?Met
165?????????????????170?????????????????175
Lys?Arg?Leu?Asn?Gly?Thr?Ala?Ala?Gly?Val?Leu?Gly?Asp?Glu?Glu?Ile
180?????????????????185?????????????????190
Leu?Arg?Met?Ala?Leu?Pro?Ala?Leu?Arg?Gly?Asp?Tyr?Arg?Ala?Ile?Glu
195?????????????????200?????????????????205
Thr?Tyr?Thr?Cys?Pro?Pro?Asp?Arg?Arg?Leu?Ala?Cys?Gly?Leu?Thr?Val
210?????????????????215?????????????????220
Leu?Thr?Gly?Glu?Asp?Asp?Pro?Leu?Thr?Thr?Val?Glu?Glu?Ala?Glu?Arg
225?????????????????230?????????????????235?????????????????240
Trp?Arg?Asp?His?Thr?Thr?Gly?Pro?Phe?Arg?Leu?Arg?Val?Phe?Thr?Gly
245?????????????????250?????????????????255
Gly?His?Phe?Phe?Leu?Thr?Gln?His?Leu?Asp?Ala?Val?Asn?Thr?Glu?Ile
260?????????????????265?????????????????270
Ala?Gln?Ala?Leu?His?Pro?Asp?Arg?Ala?Ala?Pro?Ala?Ala
275?????????????????280?????????????????285
<210>17
<211>458
<212>PRT
＜213〉streptomycete FR-008
<400>17
Met?Asp?Ser?Ala?Ala?Arg?Pro?Ile?Leu?Phe?Val?Ser?Leu?Pro?Glu?Ser
1???????????????5???????????????????10??????????????????15
Gly?Leu?Leu?Asn?Pro?Leu?Leu?Val?Leu?Ala?Gly?Glu?Leu?Ala?Arg?Arg
20??????????????????25??????????????????30
Gly?Val?Pro?Asp?Leu?Trp?Phe?Ala?Thr?Asp?Glu?His?Arg?Arg?Glu?Glu
35??????????????????40??????????????????45
Val?Glu?Ala?Leu?Ser?Asp?Val?Ser?Lys?Val?Ser?Phe?Ala?Ser?Leu?Gly
50??????????????????55??????????????????60
Glu?Val?Val?Pro?Glu?Leu?Ser?Ala?Val?Thr?Trp?Asp?Asp?Glu?Val?Tyr
65??????????????????70??????????????????75??????????????????80
Arg?Glu?Val?Thr?Gln?Ser?Ser?Arg?Phe?Lys?Ala?His?Arg?Ala?Val?Val
85??????????????????90??????????????????95
Arg?Gln?Ser?Tyr?Arg?Pro?Ala?Leu?Gln?Ala?Arg?Lys?Tyr?Arg?Glu?Leu
100?????????????????105?????????????????110
Glu?Gln?Val?Val?Asp?Glu?Val?Arg?Pro?Ala?Leu?Met?Val?Val?Asp?Cys
115?????????????????120?????????????????125
Val?Ala?Gly?Phe?Gly?Val?Asp?Leu?Ala?Leu?Ala?Arg?Gly?Ile?Pro?Tyr
130?????????????????135?????????????????140
Val?Leu?Asn?Val?Pro?Phe?Val?Ala?Ser?Asn?Val?Leu?Thr?Ser?His?Asn
145?????????????????150?????????????????155?????????????????160
Pro?Phe?Gly?Ala?Ser?Tyr?Thr?Pro?Lys?Ser?Phe?Pro?Val?Pro?Asn?Ser
165?????????????????170?????????????????175
Gly?Leu?Pro?Ala?Arg?Met?Ser?Val?Arg?Gln?Lys?Leu?Ala?Asn?Thr?Leu
180?????????????????185?????????????????190
Phe?Lys?Trp?Arg?Thr?Leu?Gly?Met?Phe?Leu?His?Pro?Asp?Met?Ala?Ala
195?????????????????200?????????????????205
Leu?Leu?Arg?Glu?Asp?Ala?Ala?Ile?Arg?Lys?Glu?Leu?Gly?Ile?Ala?Pro
210?????????????????215?????????????????220
Pro?Asn?Ala?Met?Thr?Arg?Val?Asp?Glu?Ala?Ala?Ala?Val?Val?Cys?Ser
225?????????????????230?????????????????235?????????????????240
Ser?Val?Ala?Glu?Leu?Asp?Tyr?Pro?Phe?Asp?Ile?Pro?Asp?Arg?Val?Ser
245?????????????????250?????????????????255
Leu?Val?Gly?Ala?Val?Leu?Pro?Pro?Leu?Pro?Glu?Ala?Pro?Asp?Asp?Asp
260?????????????????265?????????????????270
Glu?Val?Thr?Arg?Trp?Leu?Asp?Ala?Gln?Ser?Ser?Val?Val?Tyr?Met?Gly
275?????????????????280?????????????????285
Phe?Gly?Thr?Ile?Thr?Arg?Leu?Thr?Arg?Glu?Glu?Val?Ala?Ala?Leu?Val
290?????????????????295?????????????????300
Glu?Val?Ala?Arg?Arg?Met?Ser?Gly?Thr?His?Gln?Phe?Leu?Trp?Lys?Leu
305?????????????????310?????????????????315?????????????????320
Pro?Lys?Glu?Gln?Gln?His?Leu?Leu?Pro?Glu?Ala?Gly?Ser?Leu?Pro?Asp
325?????????????????330?????????????????335
Asn?Leu?Arg?Val?Glu?Ser?Trp?Val?Pro?Ser?Gln?Leu?Asp?Val?Leu?Ala
340?????????????????345?????????????????350
His?Pro?Asn?Val?Ser?Val?Phe?Phe?Ser?His?Gly?Gly?Gly?Asn?Ala?Tyr
355?????????????????360?????????????????365
His?Glu?Gly?Val?Tyr?Phe?Gly?Lys?Pro?Gln?Val?Val?Arg?Pro?Leu?Trp
370?????????????????375?????????????????380
Val?Asp?Cys?Phe?Asp?Gln?Ala?Val?Arg?Gly?Arg?Asp?Phe?Gly?Ile?Ser
385?????????????????390?????????????????395?????????????????400
Leu?Thr?Leu?Asp?Lys?Pro?His?Thr?Val?Asp?Pro?Asp?Asp?Val?Val?Asp
405?????????????????410?????????????????415
Lys?Leu?Thr?Arg?Val?Thr?Ser?Asp?Pro?Ala?Phe?Arg?Thr?Glu?Ala?Glu
420?????????????????425?????????????????430
Arg?Leu?Gly?Ala?Leu?Gln?Arg?Ala?Ala?Gly?Gly?Arg?Ala?Ala?Ala?Ala
435?????????????????440?????????????????445
Asp?Leu?Val?Thr?Gly?Leu?Leu?Pro?Ala?Ala
450?????????????????455
<210>18
<211>352
<212>PRT
＜213〉streptomycete FR-008
<400>18
Met?Ala?Phe?Thr?His?Pro?Val?Ser?Arg?Pro?Ala?Leu?Asp?Gly?Arg?Glu
1???????????????5???????????????????10??????????????????15
Leu?Glu?Tyr?Val?Ser?Asp?Ala?Val?Ser?Gly?Gly?Trp?Ile?Ser?Ser?Gln
20??????????????????25??????????????????30
Gly?Pro?Tyr?Val?Arg?Arg?Phe?Glu?Glu?Ala?Phe?Ala?Glu?Trp?Asn?Gly
35??????????????????40??????????????????45
Val?Ala?His?Gly?Val?Ala?Cys?Ser?Ser?Gly?Thr?Ala?Ala?Leu?Thr?Leu
50??????????????????55??????????????????60
Ala?Leu?Arg?Ala?Leu?Asn?Ile?Gly?Pro?Gly?Asp?Glu?Val?Ile?Val?Pro
65??????????????????70??????????????????75??????????????????80
Glu?Phe?Thr?Met?Val?Ala?Ser?Ala?Trp?Ala?Val?Thr?Tyr?Thr?Gly?Ala
85??????????????????90??????????????????95
Thr?Pro?Val?Phe?Val?Asp?Cys?Gly?Asp?Asp?Leu?Asn?Ile?Asp?Val?Thr
100?????????????????105?????????????????110
Arg?Ile?Glu?Glu?Lys?Ile?Thr?Pro?Arg?Thr?Arg?Ala?Val?Met?Pro?Val
115?????????????????120?????????????????125
His?Val?Tyr?Gly?Arg?Arg?Cys?Asp?Met?Asp?Ala?Val?Met?Asp?Leu?Ala
130?????????????????135?????????????????140
Leu?Gln?Tyr?Asn?Leu?Arg?Val?Val?Glu?Asp?Ser?Ala?Glu?Ala?His?Gly
145?????????????????150?????????????????155?????????????????160
Val?Arg?Pro?Val?Gly?Asp?Ile?Ala?Cys?Phe?Ser?Leu?Phe?Ala?Asn?Lys
165?????????????????170?????????????????175
Ile?Ile?Thr?Ala?Gly?Glu?Gly?Gly?Val?Cys?Leu?Thr?Asp?Asp?Pro?Arg
180?????????????????185?????????????????190
Leu?Ala?Glu?Gln?Leu?Ala?His?Leu?Arg?Ala?Met?Ala?Phe?Thr?Arg?Asp
195?????????????????200?????????????????205
His?Ser?Phe?Leu?His?Lys?Lys?Leu?Ala?Tyr?Asn?Tyr?Arg?Met?Thr?Ala
210?????????????????215?????????????????220
Met?Gln?Gly?Ala?Val?Ala?Leu?Ala?Gln?Thr?Glu?Arg?Leu?Asp?Glu?Ile
225?????????????????230?????????????????235?????????????????240
Leu?Ala?Thr?Arg?Arg?Glu?Ile?Glu?Ala?Arg?Tyr?Asp?Ala?Gly?Leu?Lys
245?????????????????250?????????????????255
Asp?Leu?Pro?Gly?Ile?Thr?Leu?Met?Pro?Ala?Arg?Asp?Val?Leu?Trp?Met
260?????????????????265?????????????????270
Tyr?Asp?Leu?Arg?Ala?Glu?Arg?Arg?Glu?Glu?Leu?Arg?Ala?His?Leu?Asp
275?????????????????280?????????????????285
Ala?Arg?Gly?Ile?Glu?Thr?Arg?Leu?Phe?Phe?Lys?Pro?Met?Ser?Arg?Gln
290?????????????????295?????????????????300
Pro?Gly?Tyr?Leu?Asp?Pro?Val?Trp?Pro?Thr?Leu?Asn?Ala?His?Arg?Phe
305?????????????????310?????????????????315?????????????????320
Ser?Glu?Asp?Gly?Leu?Tyr?Leu?Pro?Thr?His?Thr?Gly?Leu?Thr?Ala?Ala
325?????????????????330?????????????????335
Asp?Gln?Glu?Tyr?Ile?Thr?Gly?Ala?Val?Arg?Asp?Phe?Tyr?Arg?Ala?Gly
340?????????????????345?????????????????350
<210>19
<211>402
<212>PRT
＜213〉streptomycete FR-008
<400>19
Met?Ser?Ala?Thr?Arg?Thr?Ala?Arg?Glu?Arg?Ser?Arg?Ala?Ser?Arg?Ala
1???????????????5???????????????????10??????????????????15
Pro?Glu?Gly?Gly?Lys?Ala?Leu?Pro?Ser?Ala?Gly?Ala?Cys?Gln?Tyr?Ala
20??????????????????25??????????????????30
Trp?Gly?Ser?Ile?Ser?Pro?Pro?Pro?Pro?Ala?Arg?Thr?Pro?Ala?Arg?Pro
35??????????????????40??????????????????45
Val?Leu?Thr?Val?Ala?Val?Glu?Arg?Gly?Lys?Met?Ser?Lys?Arg?Ala?Leu
50??????????????????55??????????????????60
Ile?Thr?Gly?Ile?Thr?Gly?Gln?Asp?Gly?Ser?Tyr?Leu?Ala?Glu?His?Leu
65??????????????????70??????????????????75??????????????????80
Leu?Asp?Gln?Gly?Tyr?Gln?Val?Trp?Gly?Leu?Cys?Arg?Gly?Gln?Ala?Asn
85??????????????????90??????????????????95
Pro?Arg?Lys?Asp?Arg?Ile?Ala?Lys?Leu?Ile?Pro?Glu?Leu?Ser?Phe?Val
100?????????????????105?????????????????110
Asp?Gly?Asp?Leu?Met?Asp?Gln?Gly?Ser?Leu?Val?Ser?Ala?Val?Asp?Leu
115?????????????????120?????????????????125
Val?Gln?Pro?Asp?Glu?Val?Tyr?Asn?Leu?Gly?Ala?Ile?Ser?Phe?Val?Pro
130?????????????????135?????????????????140
Met?Ser?Trp?Gln?Gln?Pro?Glu?Leu?Val?Thr?Glu?Val?Asn?Gly?Thr?Gly
145?????????????????150?????????????????155?????????????????160
Val?Leu?Arg?Met?Leu?Glu?Ala?Val?Arg?Ile?Val?Ser?Gly?Leu?Thr?Lys
165?????????????????170?????????????????175
Ser?Ser?Gly?Gly?Ser?Pro?Arg?Gly?Gln?Ile?Arg?Phe?Tyr?Gln?Ala?Ser
180?????????????????185?????????????????190
Ser?Ser?Glu?Met?Tyr?Gly?Lys?Val?Ala?Glu?Ser?Pro?Gln?Arg?Glu?Thr
195?????????????????200?????????????????205
Thr?Ser?Phe?His?Pro?Arg?Ser?Pro?Tyr?Gly?Val?Ala?Lys?Ala?Phe?Gly
210?????????????????215?????????????????220
His?Tyr?Ile?Thr?Gln?Asn?Tyr?Arg?Glu?Ser?Tyr?Gly?Met?Tyr?Gly?Val
225?????????????????230?????????????????235?????????????????240
Ser?Gly?Ile?Leu?Phe?Asn?His?Glu?Ser?Pro?Arg?Arg?Gly?Ala?Glu?Phe
245?????????????????250?????????????????255
Val?Thr?Arg?Lys?Ile?Ser?Leu?Ala?Val?Ala?Gln?Ile?Lys?Leu?Gly?Gln
260?????????????????265?????????????????270
Met?Asp?Lys?Leu?His?Leu?Gly?Asn?Leu?Asp?Ala?Glu?Arg?Asp?Trp?Gly
275?????????????????280?????????????????285
Phe?Ala?Gly?Asp?Tyr?Val?Arg?Ala?Met?His?Leu?Met?Leu?Gln?Gln?Glu
290?????????????????295?????????????????300
Gln?Ala?Gly?Asp?Tyr?Val?Val?Gly?Thr?Gly?Ala?Met?His?Gln?Val?Arg
305?????????????????310?????????????????315?????????????????320
Asp?Ala?Ala?Arg?Ile?Ala?Phe?Glu?His?Val?Gly?Leu?Asp?Trp?Gln?Glu
325?????????????????330?????????????????335
His?Val?Val?Val?Asp?Pro?Gly?Leu?Val?Arg?Pro?Ala?Glu?Val?Glu?Thr
340?????????????????345?????????????????350
Leu?Cys?Ala?Asp?Ser?Gly?Asn?Ala?Arg?Arg?Glu?Leu?Gly?Trp?Glu?Pro
355?????????????????360?????????????????365
Glu?Val?Asp?Phe?Glu?Gln?Leu?Met?Arg?Met?Met?Val?Glu?Ser?Asp?Leu
370?????????????????375?????????????????380
Arg?Gln?Ala?Ser?Arg?Glu?Arg?Asp?Tyr?Ser?Gln?Leu?Leu?Ala?Thr?Gly
385?????????????????390?????????????????395?????????????????400
Ser?Trp
<210>20
<211>458
<212>PRT
＜213〉streptomycete FR-008
<400>20
Met?Pro?Ser?Thr?Cys?Pro?Ala?Pro?Thr?Ser?Ile?Gly?Phe?Arg?Gly?Cys
1???????????????5???????????????????10??????????????????15
Pro?His?Arg?Arg?Lys?Gly?Arg?Thr?Ser?Arg?Gly?Arg?Arg?Ile?Ala?Val
20??????????????????25??????????????????30
Pro?Thr?Arg?Pro?Cys?Gly?Lys?Val?Arg?Lys?Gly?His?Gln?His?Ala?Lys
35??????????????????40??????????????????45
Lys?Trp?Arg?Val?Ser?Met?Arg?Gly?Gly?Ser?Val?Ala?Val?Val?Gly?Gly
50??????????????????55??????????????????60
Ser?Ile?Ala?Gly?Cys?Ala?Ala?Ala?Leu?Ala?Ala?Ser?Arg?Gly?Gly?Ala
65??????????????????70??????????????????75??????????????????80
Glu?Arg?Ile?Thr?Val?Phe?Glu?Arg?Ala?Asp?Ala?Arg?Leu?Arg?Asp?Arg
85??????????????????90??????????????????95
Gly?Val?Gly?Ile?Gly?Val?His?Asp?Ala?Arg?Tyr?Ala?Glu?Leu?Arg?Asp
100?????????????????105?????????????????110
Ala?Gly?Tyr?Met?Ala?Asp?Glu?Met?Pro?Trp?Ala?Pro?Leu?Asn?Arg?Arg
115?????????????????120?????????????????125
Val?Trp?Ser?Val?Arg?Asp?Gly?Asp?Ala?Glu?His?Gly?Arg?Ala?Ile?Gly
130?????????????????135?????????????????140
Thr?Gln?Pro?Phe?Pro?Phe?Arg?Ala?Tyr?Asn?Trp?Gly?Ser?Leu?Trp?Ser
145?????????????????150?????????????????155?????????????????160
Glu?Leu?Arg?Arg?Arg?Val?Pro?Glu?Thr?Ala?Thr?Tyr?Arg?Ala?Gly?Ala
165?????????????????170?????????????????175
Lys?Val?Glu?Ala?Val?Glu?Gln?Asp?Ala?Asp?Gly?Val?Thr?Val?Arg?Leu
180?????????????????185?????????????????190
Ala?Asp?Gly?Glu?Pro?Glu?Arg?Phe?Asp?Leu?Val?Ile?Gly?Ala?Asp?Gly
195?????????????????200?????????????????205
Tyr?Arg?Ser?Val?Val?Arg?Glu?Ala?Met?Tyr?Pro?Gly?Thr?Gly?Ala?Ala
210?????????????????215?????????????????220
Tyr?Ala?Gly?Tyr?Ile?Gly?Trp?Arg?Gly?Thr?Ser?Pro?Asp?Val?Ser?Gly
225?????????????????230?????????????????235?????????????????240
Leu?Pro?Ser?Asp?Gly?Leu?Asp?Ala?His?Asn?Ile?Thr?Phe?Pro?Gly?Gly
245?????????????????250?????????????????255
His?Cys?Met?Ala?Tyr?Arg?Ile?Pro?Asp?Gly?Ser?Gly?Gly?His?Arg?Leu
260?????????????????265?????????????????270
Asn?Trp?Val?Leu?Tyr?Thr?Ala?Pro?Pro?Arg?Ile?Asp?Gly?Leu?His?Pro
275?????????????????280?????????????????285
Asp?Leu?Arg?Thr?Pro?Thr?Ser?Leu?Pro?Pro?Gly?Arg?Leu?Asn?Ala?Glu
290?????????????????295?????????????????300
Leu?Thr?Glu?His?Leu?Arg?Ala?Leu?Val?Ala?Glu?His?Phe?Pro?Pro?Phe
305?????????????????310?????????????????315?????????????????320
Trp?Ala?Ala?Lys?Leu?Leu?Ser?Thr?Pro?Ala?Glu?Thr?Thr?Phe?Ile?Gln
325?????????????????330?????????????????335
Pro?Ile?Tyr?Asp?Leu?Asp?Val?Pro?His?Tyr?Ala?Thr?Asp?Arg?Met?Val
340?????????????????345?????????????????350
Leu?Ile?Gly?Asp?Ala?Ala?Ser?Val?Ala?Arg?Pro?His?Leu?Gly?Ala?Gly
355?????????????????360?????????????????365
Ser?Val?Lys?Ala?Leu?Gln?Asp?Ala?Thr?Ala?Leu?Glu?Ala?Ala?Trp?Val
370?????????????????375?????????????????380
Ala?Gly?Glu?Ser?Trp?Lys?Glu?Ile?Leu?Glu?Gly?Tyr?His?Ala?Ala?Arg
385?????????????????390?????????????????395?????????????????400
Gly?Pro?Val?Gly?Thr?Ala?Met?Val?Gly?Leu?Ala?Arg?Arg?Met?Gly?Ser
405?????????????????410?????????????????415
Ala?Gln?Val?Glu?Glu?Thr?Pro?Asp?Trp?Ser?Ala?Met?Gly?Gln?Ala?Glu
420?????????????????425?????????????????430
Phe?Asp?Ala?Trp?Trp?Gln?Glu?Gln?Asn?Asn?Gly?Ser?Asp?Arg?Arg?Ser
435?????????????????440?????????????????445
Gly?Phe?Gly?Gly?His?Ser?Leu?Lys?Ser?Arg
450?????????????????455
<210>21
<211>723
<212>PRT
＜213〉streptomycete FR-008
<400>21
Met?Arg?Thr?Leu?Leu?Val?Asp?Asn?Tyr?Asp?Ser?Phe?Thr?Tyr?Asn?Leu
1???????????????5???????????????????10??????????????????15
Phe?His?Tyr?Leu?Ser?Arg?Ala?Asn?Gly?Arg?Glu?Pro?Glu?Val?Ile?Arg
20??????????????????25??????????????????30
Asn?Asp?Asp?Pro?Ala?Trp?Arg?Pro?Gly?Leu?Leu?Asp?Ala?Phe?Asp?Asn
35??????????????????40??????????????????45
Val?Val?Leu?Ser?Pro?Gly?Pro?Gly?Thr?Pro?His?Arg?Pro?Ala?Asp?Phe
50??????????????????55??????????????????60
Gly?Leu?Cys?Ala?Arg?Ile?Ala?Glu?Glu?Gly?Arg?Leu?Pro?Val?Leu?Gly
65??????????????????70??????????????????75??????????????????80
Val?Cys?Leu?Gly?His?Gln?Gly?Met?Ala?Leu?Ala?His?Gly?Ala?Arg?Val
85??????????????????90??????????????????95
Gly?Arg?Ala?Pro?Glu?Pro?Arg?His?Gly?Arg?Thr?Ser?Ala?Val?Arg?His
100?????????????????105?????????????????110
Asp?Gly?Thr?Gly?Leu?Phe?Glu?Gly?Leu?Pro?Gln?Pro?Leu?Glu?Val?Val
115?????????????????120?????????????????125
Arg?Tyr?His?Ser?Leu?Ala?Val?Thr?Glu?Leu?Pro?Pro?Glu?Leu?Glu?Ala
130?????????????????135?????????????????140
Thr?Ala?Trp?Ser?Glu?Asp?Gly?Val?Leu?Met?Ala?Leu?Arg?His?Arg?Thr
145?????????????????150?????????????????155?????????????????160
Leu?Pro?Leu?Trp?Gly?Val?Gln?Phe?His?Pro?Glu?Ser?Ile?Gly?Thr?Gln
165?????????????????170?????????????????175
Asp?Gly?His?Arg?Leu?Leu?Ala?Asn?Phe?Arg?Asp?Leu?Thr?Glu?Arg?His
180?????????????????185?????????????????190
Gly?Arg?Thr?Arg?Pro?Gly?Gly?Arg?Ala?Gly?His?Gly?Thr?Leu?Pro?Pro
195?????????????????200?????????????????205
Pro?Ala?Pro?Ala?Arg?Glu?Thr?Thr?Ala?Thr?Thr?Gly?Thr?Pro?Arg?Arg
210?????????????????215?????????????????220
Leu?Arg?Val?Ile?Ala?Glu?Ser?Leu?Pro?Thr?Arg?Trp?Asp?Ala?Glu?Val
225?????????????????230?????????????????235?????????????????240
Ala?Phe?Asp?Ser?Leu?Phe?Arg?Thr?Gly?Asp?His?Pro?Phe?Trp?Leu?Asp
245?????????????????250?????????????????255
Ser?Ser?Arg?Pro?Gly?Gly?Glu?Leu?Gly?Gln?Leu?Ser?Val?Met?Gly?Asp
260?????????????????265?????????????????270
Ala?Ser?Gly?Pro?Leu?Ala?Arg?Thr?Ala?Lys?Ala?Asp?Val?His?Ala?Gly
275?????????????????280?????????????????285
Thr?Val?Thr?Val?Arg?Ala?Asp?Gly?Ala?Ser?Ser?Thr?Val?Glu?Ser?Ala
290?????????????????295?????????????????300
Phe?Leu?Thr?Trp?Leu?Glu?Asn?Asp?Leu?Ala?Gly?Leu?Arg?Thr?Glu?Val
305?????????????????310?????????????????315?????????????????320
Pro?Glu?Leu?Pro?Phe?Ala?Phe?Ala?Leu?Gly?Trp?Val?Gly?Cys?Leu?Gly
325?????????????????330?????????????????335
Tyr?Glu?Leu?Lys?Ala?Glu?Cys?Asp?Gly?Asp?Ala?Ala?His?Arg?Ser?Pro
340?????????????????345?????????????????350
Asp?Pro?Asp?Ala?Val?Leu?Val?Phe?Ala?Asp?Arg?Ala?Leu?Val?Leu?Asp
355?????????????????360?????????????????365
His?Arg?Thr?Arg?Thr?Thr?Tyr?Leu?Leu?Ala?Leu?Val?Glu?Asp?Asp?Ala
370?????????????????375?????????????????380
Glu?Ala?Glu?Ala?Arg?Ala?Trp?Leu?Ala?Ala?Ala?Ser?Ala?Thr?Leu?Glu
385?????????????????390?????????????????395?????????????????400
Ala?Ile?Ala?Gly?Arg?Glu?Pro?Glu?Pro?Cys?Pro?Glu?Ala?Pro?Val?Cys
405?????????????????410?????????????????415
Thr?Thr?Gly?Pro?Val?Glu?Leu?Arg?His?Asp?Arg?Asp?Gly?Tyr?Leu?Lys
420?????????????????425?????????????????430
Leu?Ile?Asp?Val?Cys?Gln?Gln?Glu?Ile?Ala?Ala?Gly?Glu?Thr?Tyr?Glu
435?????????????????440?????????????????445
Val?Cys?Leu?Thr?Asn?Met?Ala?Glu?Ala?Asp?Thr?Asp?Leu?Thr?Pro?Trp
450?????????????????455?????????????????460
Ala?Ala?Tyr?Arg?Ala?Leu?Arg?Arg?Val?Ser?Pro?Ala?Pro?Phe?Ala?Ala
465?????????????????470?????????????????475?????????????????480
Phe?Leu?Asp?Phe?Gly?Pro?Met?Ala?Val?Leu?Ser?Ser?Ser?Pro?Glu?Arg
485?????????????????490?????????????????495
Phe?Leu?Arg?Ile?Asp?Arg?His?Gly?Arg?Met?Glu?Ser?Lys?Pro?Ile?Lys
500?????????????????505?????????????????510
Gly?Thr?Arg?Pro?Arg?Gly?Ala?Thr?Pro?Gln?Glu?Asp?Ala?Ala?Leu?Val
515?????????????????520?????????????????525
Arg?Ala?Leu?Ala?Thr?Cys?Glu?Lys?Asp?Arg?Ala?Glu?Asn?Leu?Met?Ile
530?????????????????535?????????????????540
Val?Asp?Leu?Val?Arg?His?Asp?Leu?Gly?Arg?Cys?Ala?Glu?Val?Gly?Ser
545?????????????????550?????????????????555?????????????????560
Val?Val?Ala?Asp?Pro?Val?Phe?Gln?Val?Glu?Thr?Tyr?Ala?Thr?Val?His
565?????????????????570?????????????????575
Gln?Leu?Val?Ser?Thr?Val?Thr?Ala?Arg?Leu?Arg?Glu?Asp?Ser?Ser?Pro
580?????????????????585?????????????????590
Val?Ala?Ala?Val?Arg?Ala?Ala?Phe?Pro?Gly?Gly?Ser?Met?Thr?Gly?Ala
595?????????????????600?????????????????605
Pro?Lys?Ile?Arg?Thr?Met?Gln?Ile?Ile?Asp?Arg?Leu?Glu?Gly?Gly?Pro
610?????????????????615?????????????????620
Arg?Gly?Val?Tyr?Ser?Gly?Ala?Ile?Gly?Tyr?Phe?Ser?Leu?Thr?Gly?Ala
625?????????????????630?????????????????635?????????????????640
Val?Asp?Leu?Ser?Ile?Val?Ile?Arg?Thr?Val?Val?Leu?Ser?Gly?Gly?Arg
645?????????????????650?????????????????655
Leu?Arg?Tyr?Gly?Val?Gly?Gly?Ala?Val?Ile?Ala?Leu?Ser?Asp?Pro?Ala
660?????????????????665?????????????????670
Asp?Glu?Phe?Glu?Glu?Thr?Ala?Val?Lys?Ala?Ala?Pro?Leu?Leu?Arg?Leu
675?????????????????680?????????????????685
Leu?Asp?Thr?Ala?Phe?Pro?Gly?Arg?Glu?Ala?Pro?Gly?Lys?Asp?Leu?Asp
690?????????????????695?????????????????700
Gly?Glu?Pro?Asp?Asp?Gly?Thr?Asp?Ala?Gly?Ala?Pro?Lys?Asp?Leu?Val
705?????????????????710?????????????????715?????????????????720
Leu?Pro?Gly
<210>22
<211>257
<212>PRT
＜213〉streptomycete FR-008
<400>22
Met?Ile?Glu?Leu?Asp?Gly?Glu?Pro?Ala?Gly?Pro?Glu?Ala?Leu?Ala?Ser
1???????????????5???????????????????10??????????????????15
Leu?Ala?Leu?Thr?Asn?Tyr?Gly?His?Phe?Thr?Thr?Leu?Leu?Val?Glu?Asn
20??????????????????25??????????????????30
Gly?Arg?Val?Arg?Gly?Leu?Asp?Leu?His?Leu?Glu?Arg?Leu?Ile?Arg?Asp
35??????????????????40??????????????????45
Cys?Arg?Thr?Leu?Phe?Asp?Ala?Ala?Leu?Asp?Pro?Asp?Arg?Val?Arg?Lys
50??????????????????55??????????????????60
Leu?Ala?Arg?Arg?Ala?Ala?Pro?Thr?Asp?Gly?Arg?Ala?Thr?Val?Arg?Val
65??????????????????70??????????????????75??????????????????80
Thr?Val?Phe?Asp?Pro?Ala?Leu?Asn?Leu?Gly?Asn?Ile?Ala?Ala?Asp?Ala
85??????????????????90??????????????????95
Arg?Pro?Gly?Ile?Leu?Val?Thr?Ser?Arg?Pro?Ala?Pro?Asp?Lys?Pro?Pro
100?????????????????105?????????????????110
Gly?Pro?Leu?Arg?Val?Arg?Ser?Val?Val?His?Arg?Arg?Asp?Leu?Pro?Glu
115?????????????????120?????????????????125
Val?Lys?Ser?Val?Gly?Leu?Cys?Pro?Thr?Leu?Arg?Leu?Arg?Arg?Gln?Ala
130?????????????????135?????????????????140
Gln?Arg?Ala?Gly?Tyr?Asp?Asp?Val?Leu?Phe?Thr?Gly?Pro?Asp?Gly?Asp
145?????????????????150?????????????????155?????????????????160
Ile?Leu?Glu?Gly?Gly?Thr?Trp?Asn?Val?Gly?Leu?Val?Arg?Asp?Gly?Glu
165?????????????????170?????????????????175
Val?Val?Trp?Pro?Gly?Gly?Glu?Val?Leu?Ala?Gly?Thr?Thr?Arg?Gln?Leu
180?????????????????185?????????????????190
Leu?Arg?Arg?Gly?His?Arg?Arg?Ser?His?Arg?Thr?Gly?Arg?Pro?Arg?Gly
195?????????????????200?????????????????205
Pro?Arg?Leu?Ser?Arg?Gly?Gly?Leu?Arg?Asp?Gln?Arg?Arg?Val?Gly?Val
210?????????????????215?????????????????220
Arg?Pro?Val?Thr?Gly?Ile?Asp?Asp?Arg?Glu?Phe?Pro?Ala?Ala?His?His
225?????????????????230?????????????????235?????????????????240
Ser?Val?Thr?Arg?Leu?Ala?Glu?Ile?Tyr?Gln?Ala?Leu?Pro?Gly?Ser?Pro
245?????????????????250?????????????????255
Leu
Claims (5)
1. polyenoid polyketone FR-008 biological synthesis gene cluster among the streptomycete FR-008 is characterized in that, comprises fscA, fscB, fscC, fscD, fscE, fscF, fscTI, fscTII, fscRI, fscRII, fscRIII, fscRIV, fscP, fscFE, fscTE, fscMI, fscMII, fscMIII, fscO, pabAB, pabC this a series of totally 21 genes and dna sequence dna thereof, be sequence 1, and the aminoacid sequence of these genes and the coded FR-008 biosynthetic enzyme of dna sequence dna thereof, i.e. sequence 2-22 are provided.
2. polyenoid polyketone FR-008 biological synthesis gene cluster is characterized in that among the streptomycete FR-008 according to claim 1, comprises comprising base 20 in the sequence 1,927-26,158 gene fscA comprises base 60 in the sequence 1,860-28,983 gene fscC, comprise base 77 in the sequence 1,587-60,962 gene fscB, comprise base 84 in the sequence 1,132-77,983 gene fscF comprises base 107 in the sequence 1,485-84,170 gene fscE comprises base 136 in the sequence 1,148-107, the nucleotide sequence of 496 gene fscD, the polyketide synthase of having encoded.
3. polyenoid polyketone FR-008 biological synthesis gene cluster is characterized in that among the streptomycete FR-008 according to claim 1, comprises comprising base 26 in the sequence 1,333-27,340 gene fscTI comprises base 27 in the sequence 1,561-28,280 gene fscTII comprises base 3 in the sequence 1,818-3,150 gene fscRI comprises base 7 in the sequence 1,205-4,377 gene fscRII, comprise base 10 in the sequence 1,320-7,210 gene fscRIII, comprise base 13 in the sequence 1,315-10,298 gene fscRIV comprises base 16 in the sequence 1,106-17,287 gene fscP comprises base 17 in the sequence 1,334-17,528 gene fscFE, comprise base 17 in the sequence 1,556-18,413 gene fscTE, comprise base 13 in the sequence 1,522-14,898 gene fscMI comprises base 14 in the sequence 1,953-16,011 gene fscMII comprises base 137 in the sequence 1,766-136,558 gene fscMIII, comprise base 1 in the sequence 1, the gene fscO of 950-574 comprises base 18 in the sequence 1,610-20,781 gene pabAB comprises base 3 in the sequence 1,037-2, the nucleotide sequence of 264 gene pabC, the abc transport albumen of having encoded is regulated albumen, FscP, Triphosphopyridine nucleotide photoreductase, II type thioester enzyme, FscM, FscM, rely on the mono-oxygenase of FAD, the para-amino benzoic acid synthetic enzyme.
4. polyenoid polyketone FR-008 biological synthesis gene cluster among the streptomycete FR-008 according to claim 1; it is characterized in that; comprise and comprise base 20 in the sequence 1; 927-26; 158 gene fscA comprises base 60 in the sequence 1,860-28; 983 gene fscC; comprise base 77 in the sequence 1,587-60,962 gene facB; comprise base 84 in the sequence 1; 132-77,983 gene fscF comprises base 107 in the sequence 1; 485-84; 170 gene fscE comprises base 136 in the sequence 1,148-107; the polyketide synthase genes encoding of 496 gene fscD include the polyketide synthase module the ketone group synthetase structure domain be the KS structural domain; the acyltransferase structural domain is the AT structural domain, and the acyl carrier protein structural domain is the ACP structural domain, and also may comprise the keto reductase structural domain is the KR structural domain; dehydrogenase structure domain is the DH structural domain, and the enoyl reductase structural domain is the polyketide synthase of ER structural domain.
5. polyenoid polyketone FR-008 biological synthesis gene cluster among the streptomycete FR-008 according to claim 1, it is characterized in that, by the FR-008 biosynthetic enzyme of sequence 2-22 definition corresponding to biosynthetic each synthesis step of FR-008 and back modification and adjusting, transhipment, correcting process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310108110 CN1667123A (en) | 2003-10-23 | 2003-10-23 | Gene cluster responsible for synthesis of FR-008 polyketone antibiotics |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310108110 CN1667123A (en) | 2003-10-23 | 2003-10-23 | Gene cluster responsible for synthesis of FR-008 polyketone antibiotics |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105014017A Division CN102021187A (en) | 2003-10-23 | 2003-10-23 | Gene cluster related to biosynthesis of FR-008 polyketone antibiotics |
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| Publication Number | Publication Date |
|---|---|
| CN1667123A true CN1667123A (en) | 2005-09-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310108110 Pending CN1667123A (en) | 2003-10-23 | 2003-10-23 | Gene cluster responsible for synthesis of FR-008 polyketone antibiotics |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101691575A (en) * | 2008-09-24 | 2010-04-07 | 中国科学院上海有机化学研究所 | Biosynthetic gene cluster of sanglifehrin |
| CN110699270A (en) * | 2018-07-10 | 2020-01-17 | 百泰生物科技股份有限公司 | Streptomyces asnyli, metabolite thereof, preparation method thereof and mosquito killing application thereof |
-
2003
- 2003-10-23 CN CN 200310108110 patent/CN1667123A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101691575A (en) * | 2008-09-24 | 2010-04-07 | 中国科学院上海有机化学研究所 | Biosynthetic gene cluster of sanglifehrin |
| CN101691575B (en) * | 2008-09-24 | 2013-06-05 | 中国科学院上海有机化学研究所 | Biosynthetic gene cluster of sanglifehrin |
| CN110699270A (en) * | 2018-07-10 | 2020-01-17 | 百泰生物科技股份有限公司 | Streptomyces asnyli, metabolite thereof, preparation method thereof and mosquito killing application thereof |
| CN110699270B (en) * | 2018-07-10 | 2021-07-23 | 百泰生物科技股份有限公司 | Streptomyces asnyli, metabolite thereof, preparation method thereof and mosquito killing application thereof |
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