CN1660029A - New technique for preparing drop pills and special dripper device - Google Patents
New technique for preparing drop pills and special dripper device Download PDFInfo
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- CN1660029A CN1660029A CN 200510053589 CN200510053589A CN1660029A CN 1660029 A CN1660029 A CN 1660029A CN 200510053589 CN200510053589 CN 200510053589 CN 200510053589 A CN200510053589 A CN 200510053589A CN 1660029 A CN1660029 A CN 1660029A
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Abstract
This invention involving a preparation method of drug mixture oral preparation and its special components,especially involving a new technology of preparing drop pills and its special components.The objective of this invention is to provide a preparation method which is suitable for the various charactestcs of the numerous drugs and can prepare drop pills above 100 mg conveniently and its special emitter device,and which makes up the deficiency of the existing drop pills preparation technology.
Description
Technical field
The present invention relates to be used for a kind of preparation method and special-purpose parts thereof of drug composition oral preparation, particularly a kind of new technology and special-purpose member thereof for preparing drop pill.
Background technology
Drop pill is to adopt solid dispersion technology, the active component of medicine and as pharmaceutically suitable carrier of substrate heat together and fusion after (can be fused solution, emulsion or suspension) splash in the not miscible with it condensing agent, utilize liquid medicine under the condition of high temperature to drip the tension force effect that the surface produces when being subjected to quenching suddenly and shrink rapidly and form the ball shape, and a kind of drug composition oral preparation of forming of condensation cured.The drop pill that utilizes above principle to be prepared from is compared with the oral formulations of routine, exists essential distinction.
Traditional oral formulations great majority are solid drugs raw material and adjuvant (mostly being powder) directly to be combined be prepared from, therefore, conventional oral formulations exists mostly that dissolve scattered time limit is long, dissolution is low, absorption difference, bioavailability is low and problem such as liver sausage first pass effect, thereby influence the performance of drug effect, also directly affect the effect of treatment.Simultaneously also to exist supplementary product consumption big for traditional oral formulations, and medicament contg is low, the preparation cost height, and volume is big, defective such as is not easy to take.In addition, traditional preparation method, dust is big in process of production, and sanitary condition is difficult to control, easily environment is polluted, and is unfavorable for the administration of health of medicine, is unfavorable for that also the direct labor's is healthy.Especially the preparation of oral preparation of Chinese traditional medicinal is all the more so.
The drop pill that adopts solid dispersion technology to be prepared from has thoroughly changed the existing defective of conventional oral formulations on the medicines structure mode.Owing to make the active component of medicine and substrate fusion be one and form liquid in advance, make active constituents of medicine fully dissolve and be dispersed in uniformly in the chemical lattice of substrate fused solution, thereby make the effective surface area of drug molecule (group) increase greatly, improved the contact area of active constituents of medicine dissolving back with gastrointestinal tract mucosa; Owing to the ease of solubility of substrate, make drop pill after taking, can dissolve rapidly, and absorbed simultaneously, played high speed, good effect efficiently by gastrointestinal tract mucosa.In addition, because the medicament contg height of drop pill, volume is little, dissolution velocity is fast, dissolving back mouthfeel is good, also can adopt the mode of sublingual administration, can make effective ingredient directly absorb and enter blood circulation by the Sublingual mucosa without gastrointestinal tract and liver, avoid the first pass effect of conventional oral formulations effectively, also avoided some drugs gastrointestinal tract to be produced the side effect that stimulates.
Existing drop pill technology of preparing, its system principle all is to rely on the fused solution contain active constituents of medicine and substrate (or emulsion, suspension) the formed medicine of self gravitation to splash into to meet in the condensed fluid quenching to shrink to form, the size that the medicine that forms drips, rely on the characteristic of medicine itself to a great extent, as temperature, density and the viscosity etc. of fused solution.The drop pill machine that forms of principle design thus, though its dripper device has increased many control modes, the ultimate principle of its system there is no any change, still relies on the gravity system of dripping of medicine fused solution self.As 1 in No. 01267426.5 Chinese utility model patent Figure of description of No. 4 mandates of in JIUYUE, 2002.Wherein water dropper partly comprises the medicinal liquid storage tank, as dripping the surge tank of depositing medicinal liquid in the system process, mostly is sealing or semitight structure.In order to guarantee to drip the temperature parameter in the system process, temperature sensor also is housed, provide the temperature controlled signal of water dropper to temperature controller.Also have in order better to guarantee to drip the relevant state parameter in the system process, detecting elements such as pressure, liquid level also are housed, with adopt various signals send into controller, by controller these parameters are controlled.Need in the preparation process by temperature control equipment the cavity space that contacts with medicinal liquid in the dripper device to be heated in advance, make the temperature parameter that satisfies the process conditions regulation, then medicinal liquid is inserted in the medicinal liquid surge tank (can adopt manual mode or finish automatically) by equipment, and keeping the stable of temperature and medicinal liquid liquid level, the pressure that medicinal liquid wherein then relies on self gravitation to produce at the drip nozzle place is flowed out by drip nozzle.Under the prerequisite that fluid temperature, liquid level and water dropper physical parameter are determined, because medicinal liquid has toughness, so the speed of its whereabouts and the time that stops in the drip nozzle exit are depended on the physical characteristics that medicinal liquid itself is had substantially, as coefficient of viscosity, density and thick rare degree etc.The physical parameter of dropping-pill machine mouth as pore size, drip nozzle length, wall thickness and even dropping-pill machine system conditions such as structure partly, all has very important effect in addition.More than numerous factors make quality index such as different to ball weight-normality lattice, the ball method of double differences of drop pill aborning, rounding rate be difficult to artificially be controlled.Simultaneously, existing technology, equipment are extremely strong for the dependency of medicinal property, drip characteristics such as system technological parameter dispersion, the difficulty of new varieties development is increased greatly, the kind that has even be difficult to find the process conditions that to implement, more can't prepare the above big specification drop pill of 100mg,, under existing processes and appointed condition, just can't realize more as for surpassing 200 and even drop pill more than the 300mg.
Yet the deficiency of Chinese medicine, one of them is exactly the prescription complexity, and dosage is big.In recent years the new product of Chinese medicine watered pill newly developed, drop pill etc., the single dose of many kinds is all more than 20.As the FUFANG DANSHEN DIWAN (each 25) that sky, Tianjin scholar's Lik-Sang produces, the Qingkailing dripping pill (each 25) that the packet header pharmaceutical factory of traditional Chinese medicine produces, the LIUWEI DIHUANG WAN of Tongrentang (each 30) etc.Even up-to-date six drugs containing rehmanniae concentrated pill, its single dose are also wanted more than 8 (180mg/ grains), this takes to the patient and brings very big inconvenience.Especially gerontal patient, hands is trembled dim eyesight mostly, the number of their grain to go out tens pillers and puts mouth more smoothly into and swallow down by no means easy.
As everyone knows, this new oral formulation of drop pill can either keep the characteristics that Chinese medicine prepares, and also has numerous advantages of modern preparation simultaneously, is the favourable approach of Chinese medicine compound preparation technical modernization.Yet because all difficult points on the aforementioned techniques, make many Chinese medicine prescriptions (the especially Chinese medicine compound of multi-flavor) be difficult in practice be prepared into to have numerous advantages, Shi Yong dropping pill formulation clinically.
Reference material: Zhang Shanyu, Li Fenglong. the application of drop pill in Chinese medicine preparation. prolong limit medical college journal 1996,19 (1) P.59-62
Summary of the invention
Purpose of the present invention is to remedy the deficiency that has the drop pill technology of preparing now, and a kind of different qualities that can be suitable for numerous types of drugs is provided, and can prepare the preparation method and the special-purpose dripper device thereof of the above big specification drop pill of 100mg easily.The present invention comprises two parts content altogether: 1. technical process (preparation method); 2. Zhuan Yong dripper device.
[technical process]
1. change material: according to the component and the ratio of different pharmaceutical raw material and substrate, correctly take by weighing each composition, place heating container or special-purpose change batch can, heat while stirring, until the fused solution that obtains containing active constituents of medicine and substrate or/and emulsion or/and suspension is standby;
2. drip system: adjust the control system of drop pill machine, make water dropper temperature, condensing agent temperature and other running parameter all can satisfy the requirement of selected kind technological parameter; Important the asking of ball according to dripping goods kind, preestablish the specification of drop pill, when treating that the water dropper temperature of drop pill machine and condensing agent temperature all reach desired state, to contain active constituents of medicine and substrate fused solution or/and emulsion or/and suspension is inserted the storage device of drop pill machine, under the control of drop pill machine, splash in the condensing agent;
3. condensation: treat medicine drop in the condensing agent condensation shrink be shaped and solidify after, take out and remove the surface condensation agent, be drying to obtain.
4. technical process explanation:
4.1 method 1 described medicine material, can be the Chinese medicine of any folk prescription, compound recipe, or their effective ingredient, effective site, also can be the extract of pharmaceutically active ingredient or effective site in containing, also can be the chemicals of any folk prescription or compound recipe, and the mixture of above-mentioned various kinds of drug; As pharmaceutically suitable carrier of substrate as the mixture of one or more in pharmaceutically suitable carrier such as polyethylene glycols, sorbitol anhydride class, polyoxyethylene sorbitol acid anhydride class, polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac; According to the difference of use medicine material, be unit with g or kg, by weight, medicine material: substrate=1: 0.5～1: 5;
Can heavily give quantitative control to the ball of drop pill in advance as required 4.2 feature 1 of the present invention is that method 3 is described, this feature is finished by the dripper device of special use;
4.3 feature 2 of the present invention, just be the medicine material characteristic and the specification difference that prepare as required, need to select satisfactory condensing agent, usually need be determined commonly used dimethicone, liquid paraffin arranged, eat wet goods by test, big as medicinal liquid viscosity, maybe need to prepare the drop pill of big specification, then should select the bigger condensing agent of viscosity coefficient, for example use dimethicone, just should select the higher kind of label; Or utilize and reduce the viscosity that the condensing agent method of temperature increases condensing agent, for example for the solidified medicine material that just can be shaped at a lower temperature, just can adopt liquid paraffin or edible oil as condensing agent, adopt lower condensation temperature simultaneously, increase their viscosity; The length that also can increase condensation column is to increase the cooling distance, the solidified effect thereby raising is shaped;
4.4 feature 3 of the present invention, be to select the refrigerative thermograde of water dropper temperature and condensing agent, the temperature of water dropper equates with the temperature of changing material or close in the drop pill preparation process, usually selectable range is between 50 ℃～170 ℃, most of herbal species, the water dropper temperature that is suitable for is below 100 ℃, and the temperature of part chemical medicine can reach more than 150 ℃; The thermograde of condensing agent, top are 50 ℃～10 ℃, and the bottom is 10 ℃～-10 ℃, intermediary temperature be by heat to cold continually varying, avoid occurring thermocline.
Following table is that example provides one group of empirical data with the LIUWEI DIHUANG WAN:
| Drop pill weight | The silicone oil label | The condensing agent temperature | Remarks | |
| LIUWEIDIHUANG DIWAN | 100mg | ?100～150 | ?20℃～5℃ | |
| LIUWEIDIHUANG DIWAN | 200mg | ?200～250 | ?25℃～5℃ | |
| LIUWEIDIHUANG DIWAN | 300mg | ?300～350 | ?28℃～0℃ | |
| LIUWEIDIHUANG DIWAN | 400mg | ?500 | ?35℃～-5℃ |
[special-purpose dripper device]
The drop pill machine that big specification drop pill preparation technology involved in the present invention is adopted, its dripper device and the dripper device of existing drop pill machine have in essence different.Its ultimate principle of dripper device involved in the present invention as shown in Figure 1, among Fig. 1,1 is quantitative plunger rod, 3 is charging aperture, discharging opening check valve, 9 is the main body of dripper device, formed by metal material processing, its inside includes the plunger rod active chamber, and has and extraneous charging aperture, the discharging opening that communicates.When quantitative plunger rod when arrow right is moved, plunger rod chamber internal volume of living in enlarges, pressure reduces, medicinal liquid is entered by charging aperture and is full of plunger rod and retreats the volume space of being abdicated.To left movement, plunger rod chamber internal volume of living in reduces plunger rod along arrow then, and pressure strengthens, this moment the discharging opening one-way valve opens, the medicinal liquid in the plunger cavity is subjected to plunger and moves formed pressure and discharge through discharging opening.Change the stroke of quantitative plunger rod, can regulate the volume of each charging easily, thereby can change the size of drop pill specification easily.Having avoided conventional drips system institute by gravity or pressurization and is beyond one's reach and drips a system effect.This formulation amount device belongs to the positive displacement proportioning device, and quantitative accuracy drips the system mode far above routine, makes in different the reaching of the ball method of double differences ± 2% of drop pill.
[beneficial effect]
Drop pill is to adopt solid dispersion technology, the active component of medicine and as pharmaceutically suitable carrier of substrate heat together and fusion after (can be fused solution, emulsion or suspension) splash in the not miscible with it condensing agent, utilize liquid medicine under the condition of high temperature to drip the tension force effect that the surface produces when being subjected to quenching suddenly and shrink rapidly and form the ball shape, and a kind of drug composition oral preparation of forming of condensation cured.
Existing drop pill technology of preparing, its system principle all is to rely on the fused solution contain active constituents of medicine and substrate (or emulsion, suspension) the formed medicine of self gravitation to splash into to meet in the condensed fluid quenching to shrink to form, the size that the medicine that forms drips, rely on the characteristic of medicine itself to a great extent, as temperature, density and the viscosity etc. of fused solution.The drop pill machine that forms of principle design thus, though its dripper device has increased many control modes, the ultimate principle of its system there is no any change, still relies on the gravity system of dripping of medicine fused solution self.Existing drop pill preparation technology, equipment are extremely strong for the dependency of medicinal property, make that dripping a system technological parameter disperses, and quality index such as ball weight-normality lattice, the ball method of double differences to drop pill in the production is different, rounding rate are difficult to artificially be controlled.Thereby the difficulty of drop pill new varieties development is increased greatly, the kind that has even be difficult to find the process conditions that to implement, more can't prepare the above big specification drop pill of 100mg, as for surpassing 200 and even drop pill more than the 300mg, under existing processes and appointed condition, just can't realize more.
The new technology that is used to prepare drop pill involved in the present invention, adopt drop pill weight given in advance, and appropriately select condensing agent kind and temperature, make the influence of in the drop pill preparation process, thoroughly having broken away from numerous factors, fundamentally changed traditional handicraft in preparation process for the strong excessively shortcoming of medicinal property dependency, not only can prepare the above big specification drop pill of 100mg easily, and technical specification is artificially controlled easily to specification, the ball method of double differences of drop pill be different etc., thereby the accuracy and the safety that have improved patient's dosage greatly.
Utilize new technology involved in the present invention, can be prepared into numerous outstanding Chinese medicines tradition compound recipes and both meet modernization of Chinese medicine requirement, kept newtype drug oral formulations---the drop pill of Chinese medicine basic characteristics again.
Description of drawings
1. Figure of description 1 is the schematic diagram of having simplified, simultaneously the accompanying drawing of book extract as an illustration;
2. Figure of description 2 is embodiment accompanying drawings that a check valve only is housed at discharging opening;
3. Figure of description 3 is embodiment accompanying drawings that a check valve respectively is housed at charging aperture and discharging opening;
4. Figure of description 4 is the embodiment accompanying drawings that adopt camshaft control formula mechanical type check valve.
The specific embodiment
Below in conjunction with several groups of specific embodiments, drop pill new preparation process involved in the present invention is described further.
[experiment of big specification method for preparing drop pills]
1. the experiment of different pharmaceutical raw material
In order to observe with the different pharmaceutical is the product quality that raw material adopts the big specification drop pill that preparation method involved in the present invention is prepared from, respectively with effective ingredient (the being equivalent to chemicals) ligustrazine phosphate of 1. single medicinal materials, 2. the effective site Radix Notoginseng total arasaponins of single medicinal material, 3. the extract dry powder of single medicinal material Radix Isatidis, 4. the extract dry powder of Chinese medicine compound six drugs containing rehmanniae, 5. the mixture of chemical medicine berberine and Chinese medicine Fructus Evodiae extract dry powder is a medicine material, adopt preparation method involved in the present invention to be prepared, can make the embodiment of 5 kinds of above drop pill of 100mg, and obtain 5 groups of experimental results and see Table 1:
2. the group practices of different substrates
For pharmaceutically suitable carrier of observing with various combination is a substrate, adopt the product quality of the big specification drop pill that preparation method involved in the present invention is prepared from, be example with LIUWEIDIHUANG DIWAN, Compound Allantoin Pill, maloic acid drop pill, drop pills of oil of zedoary turmeric respectively, adopt preparation method involved in the present invention to be prepared, can make 4 kinds of embodiment that use the various combination carriers as substrate, and obtain 4 groups of experimental results and see Table 2:
3. the experiment of medicine material and the different proportionings of substrate
Mix mutually in varing proportions with substrate in order to observe medicine material, adopt the product quality of the big specification drop pill that preparation method involved in the present invention is prepared from, with 1: 0.8,1: 1,1: 2.2,1: 3,1: 5 ratio medicine material is mixed with matrix phase respectively, adopt preparation method involved in the present invention to be prepared, can make the drop pill of 5 kinds of different sizes, and obtain 5 groups of experimental results and see Table 3:
4. the experiment of water dropper temperature
In order to observe under different water dropper temperature, adopt the product quality of the big specification drop pill that preparation method involved in the present invention is prepared from, respectively under 60 ℃, 75 ℃, 95 ℃, 120 ℃, 150 ℃ water dropper temperature, adopt preparation method involved in the present invention to be prepared, can make the drop pill of 5 kinds of different sizes, and obtain 5 groups of experimental results and see Table 4:
5. select the experiment of condensing agent
Select different condensing agents in order to observe, adopt the product quality of the big specification drop pill that preparation method involved in the present invention is prepared from, respectively with the dimethicone of different labels and liquid paraffin as condensing agent, adopt preparation method involved in the present invention to be prepared, can make the drop pill of 5 kinds of different sizes, and obtain 5 groups of experimental results and see Table 5:
6. the experiment of condensing agent temperature and gradient
Select different condensing agent temperature and thermograde in order to observe, adopt the product quality of the big specification drop pill that preparation method involved in the present invention is prepared from, the thermograde of condensing agent is respectively 40 ℃～-10 ℃ from top to bottom, 40 ℃～-10 ℃, 40 ℃～-10 ℃, 40 ℃～-10 ℃, in the time of 40 ℃～-10 ℃, adopt preparation method involved in the present invention to be prepared, can make the drop pill of 5 kinds of different sizes, and obtain 5 groups of experimental results and see Table 6:
Table 1 adopts the big specification drop pill experiment of different pharmaceutical feedstock production
Table 2 adopts the big specification drop pill experiment of different substrates combined preparation
Table 3 adopts the big specification drop pill experiment of different mixing proportion preparation
The big specification drop pill experiment that table 4 prepares under different water dropper temperature
Table 5 adopts the big specification drop pill experiment of different condensing agent preparations
Table 6 adopts the big specification drop pill experiment of different condensing agent thermograde preparations
[embodiment of special-purpose dripper device]
Embodiment 1: do not bring the dripper device of material list to valve into
Fig. 2 is a kind of implementation of quantitatively dripping dripper device in the system special equipment, and this device is not installed check valve in medicinal liquid import department, and a check valve only is housed in the exit.1 is quantitative plunger rod among the figure, and 2 is water dropper, and 3 is the discharging opening check valve, and 4 is spring, and 5 is feeding opening, and 6 is plunger cavity, and 7 is screw plug, and 8 is sealing ring, and 9 is the main body of dripper device.When plunger rod when the direction of arrow retreats, plunger rod chamber internal volume of living in enlarges, pressure reduces, medicinal liquid enters and is full of plunger rod and retreats the volume space of being abdicated.When plunger rod advanced, cavity pressure increased, and check valve is subjected to this pressure and opens, and medicinal liquid oozes from water dropper by the one-way cock of discharging opening.This device is not because the feeding opening place has check valve, push ahead at plunger rod and to have the part medicinal liquid in the process and reflux from charging aperture, but by adjusting the pressure of spring 4, still can guarantee the plunger rod each run from water dropper go out the dose basically identical, thereby realize the system of quantitatively dripping.
Fig. 3 is the another kind of implementation of quantitatively dripping dripper device in the system special equipment, and this device also is equipped with a check valve at the charging aperture place.1 is quantitative plunger rod among the figure, and 2 is water dropper, and 3 are check valve (comprising each one at charging aperture and discharging opening place), and 4 is spring, and 5 is feeding opening, and 6 is plunger cavity, and 7 is screw plug, and 8 is sealing ring, and 9 is the main body of dripper device, and check valve is the passive mode of spring compression.When plunger rod when the direction of arrow retreats, plunger rod chamber internal volume of living in enlarges, pressure reduces, the charging aperture one-way valve opens, discharging opening closed check valve, medicinal liquid enter and are full of plunger rod by the charging aperture check valve and retreat the volume space of being abdicated.When plunger rod was pushed ahead, cavity pressure increased, and discharging opening check valve pressurized is opened, the charging aperture closed check valve, and medicinal liquid oozes from water dropper by the discharging opening check valve.
Employed check valve adopts the passive valve mode of spring compression among the embodiment 1,2, also can not adopt this kind passive valve mode, and adopts the active drive mode to control the into switching of medicine and drug check valve, realizes and the quantitatively interlock of plunger rod.
Fig. 4 is the 3rd a kind of mode of the system of quantitatively dripping, and wherein: 1 is quantitative plunger rod, and 2 is camshaft, and 3 is check valve, and 4 is cam, and 5 is feeding opening, and 6 is medicine outlet.When camshaft rotates according to direction as shown, drive three cams and rotate simultaneously.When camshaft rotates to left figure position, left side cam runs to the end that closely stops, the feeding opening state is for opening, right cam runs to the end that far stops, and the medicine outlet state is held the process of the end that closely stops because intermediate cam enters far to stop simultaneously for closing, driving quantitative plunger rod moves upward, plunger rod cavity volume of living in enlarges, and pressure reduces, and medicinal liquid is entered by feeding opening and is full of the volume space that plunger rod rises and abdicated.After plunger rod rose to the top, intermediate cam ran to the end that closely stops, and to the end operation of far stopping, close thereupon by the feeding opening check valve by the end that closely stops for left cam.After left cam ran to the end that far stops, right cam began to be moved to the end that closely stops by the end that far stops, and the medicine outlet check valve is opened thereupon.After right cam entered the end that closely stops, intermediate cam began to be moved to the end that far stops by the end that closely stops, and drive plunger rod moves downward, and cavity pressure increases, and medicinal liquid is discharged by medicine outlet, finishes once circulation.Owing to adopted the mechanical type check valve, be not subjected to the interference of other factors, so the ball method of double differences of medicinal liquid is different can be more accurate.
Claims (5)
1. a new technology that can be used for preparing the above big specification drop pill of 100mg is made up of change material, a system, three processes of condensation, it is characterized in that:
1.1 described system process is meant and can by the volume control to water dropper, heavily gives quantitative system process to the ball of drop pill in advance as required, finished by the dripper device of special use;
1.2 describedization material, a system process, its operating temperature is 50 ℃～170 ℃;
1.3 described condensation process, employed condensing agent are dimethicone or liquid paraffin or edible oil;
1.4 described condensation process, selection for condensing agent has following rule: the medicinal liquid viscosity that contains medicine material increases, or the increase of the drop pill specification of required preparation, then should select the bigger condensing agent of viscosity coefficient or/and reduce the condensing agent temperature or/and increase refrigerative distance or time;
1.5 described condensation process, the operating temperature gradient of condensing agent, top is 50 ℃～10 ℃, the bottom is 10 ℃～-10 ℃.
2. the new technology that is used to prepare big specification drop pill as claimed in claim 1, it is characterized in that describedization material process, be meant medicine material and substrate mixed and heating, until the fused solution that obtains containing active constituents of medicine and substrate or/and emulsion or/and the process of suspension, wherein:
2.1 described medicine material can be the Chinese medicine of any folk prescription, compound recipe, or their effective ingredient, effective site, also can be the extract that contains middle pharmaceutically active ingredient or effective site, also can be the chemicals of any folk prescription or compound recipe, and the mixture of above-mentioned various kinds of drug;
2.2 described substrate is polyethylene glycols, sorbitol anhydride class, polyoxyethylene sorbitol acid anhydride class, polyoxyethylene stearate 40 esters, betacyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac, the mixture of one or more in above-mentioned pharmaceutically suitable carrier;
2.3 with g or kg is unit, according to the weight portion meter, the mixed proportion of described medicine material and substrate is:
Medicine material: substrate=1: 0.5～1: 5.
3. one kind is used to prepare the above dripper device of specification drop pill greatly of 100mg, by quantitative plunger rod 1, discharging opening one-way cock 3 and dripper device main body 9 constitute, body interior includes the plunger rod active chamber, and have and the extraneous charging aperture that communicates, discharging opening, when quantitative plunger rod is outwards pulled out in its active chamber, plunger rod chamber internal volume of living in enlarges, pressure reduces, and medicinal liquid is entered by charging aperture and is full of plunger rod and retreats the volume space of being abdicated, and plunger rod inwardly advances again then, the chamber internal volume reduces, pressure strengthens, this moment the discharging opening one-way valve opens, the medicinal liquid in the plunger cavity is discharged through discharging opening and is formed medicine and drip.
4. dripper device as claimed in claim 3 is characterized in that: at charging aperture and discharging opening place check valve is housed simultaneously.
5. dripper device as claimed in claim 3 is characterized in that: described check valve is the passive valve mode that adopts spring compression, or adopts the active drive mode, or by the machinery of camshaft control.
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| CN 200410070579 CN1586454A (en) | 2004-08-10 | 2004-08-10 | New process for preparing dripping pills and its special dripping device |
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| CN100382790C (en) * | 2005-09-02 | 2008-04-23 | 北京正大绿洲医药科技有限公司 | Compound yew drop pills and its preparation method |
| CN101491483B (en) * | 2008-12-24 | 2011-12-28 | 烟台开发区博森制药机械有限公司 | Step-by-step pressurization air-blasting fine drop-pills dripper |
| CN101518495B (en) * | 2009-03-26 | 2011-12-28 | 天津大学 | Vibration crushing type pill dropping machine |
| CN104042445A (en) * | 2013-12-25 | 2014-09-17 | 江西济民可信药业有限公司 | Multi-row dropping head device with pressure-dividing disc special for preparing big dropping pill of over 100mg |
| CN104042445B (en) * | 2013-12-25 | 2016-08-17 | 江西省药明扬海医药科技有限公司 | What a kind of more than the 100mg of preparation large dripping pillar was special has multiple rows of dripper device of dividing potential drop dish |
| CN108024909B (en) * | 2015-09-18 | 2020-07-10 | 天士力医药集团股份有限公司 | Continuous intelligent preparation method of liquid cooling dropping pills |
| CN106539690A (en) * | 2015-09-18 | 2017-03-29 | 天士力制药集团股份有限公司 | A kind of continuous intelligent preparation method of liquid cooling drop pill |
| CN108024909A (en) * | 2015-09-18 | 2018-05-11 | 天士力医药集团股份有限公司 | A kind of continuous intelligent preparation method of liquid cooling dripping pill |
| US10813840B2 (en) | 2015-09-18 | 2020-10-27 | Tasly Pharmaceutical Group Co., Ltd. | Intelligent continuous manufacturing method via liquid cooling of dripping pills |
| CN106539690B (en) * | 2015-09-18 | 2020-08-04 | 天士力医药集团股份有限公司 | Continuous intelligent preparation method of liquid cooling dropping pills |
| CN107411079A (en) * | 2017-04-05 | 2017-12-01 | 福建春秋展业生物科技有限公司 | A kind of agate card matrimony vine dripping pill preparation method |
| CN108046202B (en) * | 2017-11-30 | 2019-09-27 | 武平县旺发电子商务有限公司 | A kind of automatic conveying device of water dropper |
| CN108046202A (en) * | 2017-11-30 | 2018-05-18 | 中山市榄商置业发展有限公司 | A kind of automatic conveying device of water dropper |
| CN111449958A (en) * | 2020-04-29 | 2020-07-28 | 国药控股星鲨制药（厦门）有限公司 | Feeding device for dropping pills |
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