CN104042445B - What a kind of more than the 100mg of preparation large dripping pillar was special has multiple rows of dripper device of dividing potential drop dish - Google Patents
What a kind of more than the 100mg of preparation large dripping pillar was special has multiple rows of dripper device of dividing potential drop dish Download PDFInfo
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- CN104042445B CN104042445B CN201310727248.3A CN201310727248A CN104042445B CN 104042445 B CN104042445 B CN 104042445B CN 201310727248 A CN201310727248 A CN 201310727248A CN 104042445 B CN104042445 B CN 104042445B
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- drip nozzle
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- 238000002360 preparation method Methods 0.000 title abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 59
- 239000003814 drug Substances 0.000 claims abstract description 23
- 239000006187 pill Substances 0.000 claims description 33
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
- 239000010935 stainless steel Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 40
- 238000004519 manufacturing process Methods 0.000 description 21
- 230000000694 effects Effects 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 5
- 230000002262 irrigation Effects 0.000 description 5
- 238000003973 irrigation Methods 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000005265 energy consumption Methods 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 229960001866 silicon dioxide Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000009220 Liuwei Dihuang Decoction Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000002789 length control Methods 0.000 description 1
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- 230000008018 melting Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention belongs to pharmaceutical machine apparatus field, be specifically related to multiple rows of dripper device with medicinal liquid dividing potential drop dish that a kind of more than the 100mg of preparation large dripping pillar is special.Dripper device of the present invention includes with lower component: dripper device upper cover (1), gim peg (2), medicinal liquid dividing potential drop dish (3), rubber cushion (4), dripper device lower cover (5), inner ring drip nozzle and outer ring drip nozzle (6), liquid medicine flow district (7).
Description
Technical field
The invention belongs to pharmaceutical machine apparatus field, the medicinal liquid that has being specifically related to a kind of more than the 100mg of preparation large dripping pillar special divides
Multiple rows of dripper device of platen.
Background technology
Drop pill is to use solid dispersion technology, the active component of medicine is heated with together with pharmaceutically suitable carrier of substrate and melts
During (can be fused solution, emulsion or suspension) instills the most miscible condensing agent afterwards, utilize liquid medicine under the condition of high temperature
Tension force effect that when dripping suddenly by being quenched, surface produces and shrink rapidly formation pellet, and a kind of medicine group of condensation cured
Compound oral formulations.Utilize the drop pill that principles above is prepared from compared with conventional oral formulations, there is essential distinction.
Existing drop pill technology of preparing, its dripping principle is all dependent on fused solution containing active constituents of medicine and substrate (or milkiness
Liquid, suspension) medicine that formed of self gravitation instills and meets quenching contraction in condensed fluid and form, the size that formed medicine drips, the most greatly
The characteristic of medicine itself is relied on, such as temperature, density and the viscosity etc. of fused solution in degree.The thus pill dripping machine of principle design,
Although its dripper device adds many control modes, but the ultimate principle of its dripping there is no any change, relies on medicine and melts
The gravity melting liquid self carries out dripping, if it is desired to increase the weight of ball, particularly more than 100mg ball weight, it is necessary to rely on external force
Complete with some control systems.As " Zhengda-Luzhou Medicine Science-Technology Co., Ltd., Beijing " application and authorized " prepared by one
The new technology of drop pill and special dripper device thereof ", Patent No.: the patent of invention of " 2005100535892 ", its water dropper fills
The dripping principle put is the reciprocating motion dripping large dripping pillar utilizing external force to make plunger, move back and forth every time can only one large dripping pillar of dripping,
Be not suitable for industrialization to produce.And for example " Zhengda-Luzhou Medicine Science-Technology Co., Ltd., Beijing " application and authorized " one is used for making
The dripper device of standby drop pill ", Patent No.: the utility model patent of " 200520018541.3 ", its principle be utilize air pressure and
The control of valve, a kind of dripper device of dripping large dripping pillar, this patent simply describes medicinal liquid under constant air pressure, control valve
The opening time dripping large dripping pillar of door, and the arrangement mode of water dropper and quantity are not recorded, and are the most further studied.
Existing commercially available large dripping pillar produces equipment, such as dripping that Yantai City " Yantai hundred Yao Tai Chinese medicine Science and Technology Ltd. " produces
Ball machine, the dripping principle of its dripping large dripping pillar is to utilize above-mentioned utility model patent 200520018541.3, " a kind of for preparation droplet
The dripper device of ball ", dripping large dripping pillar, it is disadvantageous in that: the arrangement mode of water dropper is equidistant in the periphery of disk
Arrangement water dropper, utilizes this pill dripping machine dripping large dripping pillar, and production capacity is low, and multipotency of every 5-7 second drips the big ball of 20-24 grain, production cycle
Long, relative power consumption is big, wastes man-hour.
Presently commercially available dripper device is single water dropper, and production efficiency is low, cost is high.If only single water dropper being changed into double
Or after multiple rows of water dropper, the drop pill obtained exists mass defect, owing to being fitted without bleeder mechanism, medicinal liquid pressure experienced can not
Uniformly, there is the problem that the weight difference opposite sex is big in the drop pill obtained.This patent not only increases the quantity of water dropper and adds dividing potential drop
Device, makes inside and outside two row pressure power consistent, the problem well solving pill weight variation.
It addition, in presently commercially available dripper device, water dropper and drip nozzle are not one, single drip nozzle screw on water dropper and form,
The most mutual collision deformation between drip nozzle and production utensil, increases medicinal liquid resistance, reduces production efficiency in process of production.
Summary of the invention
It is an object of the invention to make up above-mentioned existing commercially available pill dripping machine, to prepare large dripping pillar production capacity low, and the production cycle is long, and energy consumption is big, work
The deficiencies such as duration, it is provided that the one that a kind of yield is high, with short production cycle, energy consumption is little, production hour is short prepares more than 100mg
What large dripping pillar was special has multiple rows of dripper device of dividing potential drop dish, and its production capacity is single 2 times.
Water dropper and the drip nozzle of the present invention is global design simultaneously, and drip nozzle is in water dropper lower end plane, drips during stopping to use
Collision deformation between mouth and production utensil, decreases medicinal liquid resistance simultaneously, makes medicinal liquid can pass through drip nozzle, improves production effect
Rate.
Specifically, multiple rows of water dropper with medicinal liquid dividing potential drop dish that a kind of more than the 100mg of preparation large dripping pillar involved in the present invention is special
Device, have substantially from the dripper device of existing pill dripping machine is different.
Its ultimate principle of dripper device involved in the present invention as shown in Figure 1 or 2, including with lower component: dripper device upper cover
(1), gim peg (2), medicinal liquid dividing potential drop dish (3), rubber cushion (4), dripper device lower cover (5), inner ring drip nozzle and outer ring drip nozzle
(6), liquid medicine flow district (7).
Each parts annexation involved in the present invention is as follows: between dripper device upper cover (1) and dripper device lower cover (5)
For liquid medicine flow district (7), medicinal liquid dividing potential drop dish (3) is arranged on dripper device lower cover (5), at water dropper by gim peg (2)
The inside of the both sides of device lower cover (5) is provided with inner ring drip nozzle and outer ring drip nozzle equipped with rubber cushion (4), dripper device lower cover (5)
(6).
The dripper device of the present invention can be single or multiple rows of dripper device, the most double dripper device.
Wherein, dripper device upper cover (1), gim peg (2), medicinal liquid dividing potential drop dish (3), rubber cushion (4), dripper device lower cover (5),
Inner ring drip nozzle and outer ring drip nozzle (6) are stainless steel；
Wherein, inner ring drip nozzle and outer ring drip nozzle (6) can arrange multiple rows of, generally 2 rows, 3 rows, 4 rows or 5 rows.
The bottom of water dropper is drip nozzle, and water dropper and drip nozzle use integrated design, and drip nozzle designs in drip tray plane.Water dropper integration,
Difficulty of processing can be reduced, water dropper collision deformation each other during stopping to use, decrease medicinal liquid resistance simultaneously, make medicinal liquid
Drip nozzle can be passed through, improve production efficiency.
Wherein, rubber cushion, is 2-3ml silicagel pad for thickness, and its effect is to make to have between water dropper upper cover and water dropper lower cover preferably
Sealing function, another effect is to make to produce the cavity that can make liquid medicine flow between water dropper upper cover and water dropper lower cover, i.e. produces medicinal liquid stream
Dynamic district.
Wherein, the aperture of the drip nozzle of each water dropper lower end is formed objects, and its standard is consistent.
Wherein, the drop pill weight oozed from drip nozzle, is under constant air pressure effect, by adjusting electromagnetic valve (or plunger)
Opening time and ooze.
Wherein, water dropper upper cover and water dropper lower cover are sealed by spiral and silicagel pad.
Wherein, liquid medicine flow district is connected with a medicinal cupping of pill dripping machine；Medicinal liquid at constant air pressure and adjusts electromagnetic valve from drip irrigation
Opening time enters in dripper device liquid medicine flow district；
Wherein, medicinal liquid dividing potential drop dish, its outer rim is in inner ring drip nozzle and the centre of inner ring drip nozzle, and is fixed under water dropper and covers, and it is made
With being to make medicinal liquid entrance inner ring drip nozzle identical with the amount of outer ring drip nozzle, born pressure is impartial.Its principle is by dividing potential drop dish
Making medicinal liquid enter the distance of inner ring drip nozzle and outer ring drip nozzle, equal (if without dividing potential drop dish, then medicinal liquid is introduced into inner ring drip nozzle, laggard
Enter outer ring drip nozzle, owing to inner ring drip nozzle and outer ring drip nozzle are apart from different and make medicinal liquid power different, eventually result in the medicine oozed
Ball weight there are differences).
The present invention also provides for the installation method of dripper device, comprises the following steps:
First medicinal liquid dividing potential drop dish is fixed under dripper device and covers, cover placement rubber cushion under water dropper, water dropper is arranged under water dropper
Cover, dripper device upper cover and dripper device lower cover combined so that it is seal,.
The drop pill weight of the production of the present invention is at more than 100mg, including 100mg, 200mg, 300mg, 400mg, 500mg
Deng.
The operation principle of dripper device of the present invention: medicinal liquid is under constant external force and electromagnetic valve (or plunger) act on, and medicinal liquid is from dripping
Fill in the flow region (7) entering dripper device, under the effect of medicinal liquid dividing potential drop dish (3), by constant external force and regulation electricity
The opening time of magnet valve (or plunger), to adjust the weight of drop pill, makes medicinal liquid ooze from inner ring drip nozzle and outer ring drip nozzle, obtains institute
The drop pill needed.
Constant external force: control air pressure by air pressure regulator and produce constant air pressure external force.
Electromagnetic valve (or plunger): be contained in drip tray, it act as making medicinal liquid produce pulse, controls water dropper dripping pill, can pass through
The regulation burst length controls pill weight.This device is the device of former Patent No. " 2005100535892 ".
Multiple rows of dripper device with dividing potential drop dish that a kind of more than the 100mg of preparation large dripping pillar involved in the present invention is special, is to pass through
Medicinal liquid, in dripper device herb liquid dividing potential drop dish effect, oozes big dripping by adjusting air pressure suffered by medicinal liquid and the opening time of electromagnetic valve
Ball, this dripper device, compared with dripper device in presently commercially available pill dripping machine, is to make up big of above-mentioned commercially available pill dripping machine preparation
Ball production capacity is low, and the production cycle is long, and energy consumption is big, man-hour the deficiency such as length, it is provided that it is a kind of that yield is high, with short production cycle, energy consumption is little,
Multiple rows of dripper device with medicinal liquid dividing potential drop dish that short a kind of more than the 100mg of the preparation large dripping pillar of production hour is special.
Accompanying drawing explanation
Accompanying drawing 1 is the dripper device sectional view of the present invention.
Accompanying drawing 2 is the dripper device sectional, exploded view of the present invention.
In figure: 1 is dripper device upper cover, 2 is gim peg, and 3 is medicinal liquid dividing potential drop dish, and 4 is rubber cushion, and 5 is dripper device lower cover,
6 is inner ring drip nozzle and outer ring drip nozzle, and 7 is liquid medicine flow district.
Detailed description of the invention
By specific examples below, the present invention is further illustrated, but without limitation.
Embodiment 1, dripper device
Dripper device involved in the present invention, mainly by dripper device upper cover (1), gim peg (2), medicinal liquid dividing potential drop dish (3),
Rubber cushion (4), dripper device lower cover (5), inner ring drip nozzle and outer ring drip nozzle (6), liquid medicine flow district (7) form.
Its each parts annexation is as follows: be liquid medicine flow district between dripper device upper cover (1) and dripper device lower cover (5)
(7), medicinal liquid dividing potential drop dish (3) is arranged on dripper device lower cover (5), in dripper device lower cover (5) by gim peg (2)
The inside of both sides equipped with rubber cushion (4), dripper device lower cover (5) is provided with inner ring drip nozzle and outer ring drip nozzle (6).
Wherein, inner ring drip nozzle and outer ring drip nozzle (6) can arrange multiple rows of, generally 2 rows, 3 rows, 4 rows or 5 rows.
Wherein, water dropper upper cover and water dropper lower cover are sealed by spiral and silicagel pad.
Embodiment 2, different dripper device Performance comparision
Dripper device and the existing apparatus of the present invention are compared, its performance is investigated.
Experimental technique:
Respectively by the drip tray of application number 2005100535892, the drip tray of application number 2005200185413 on same pill dripping machine
And the same medicinal liquid of drip tray dripping of patent of the present invention, its result is as follows:
Test result:
Experimental result shows: the quantity of present invention production per minute drop pill is significantly more than existing apparatus, and speed of production is fast, low cost；
The drop pill that the present invention produces, compared with the drop pill that existing equipment produces, also has steady quality, and drop pill weight differential is little, outward appearance
Completely, the feature such as moderate viscosity.
Embodiment 3, the preparation process of drop pill
Using existing commercially available pill dripping machine, its dripper device uses the double dripper device with medicinal liquid dividing potential drop dish of the present invention to produce six
Taste Dihuang dropping pills, specification is 300mg)
Take in the drip irrigation that the preparation liquid of the LIUWEIDIHUANG DIWAN that prepared puts pill dripping machine, airtight drip irrigation.The water dropper of the present invention is filled
Put (dripper device installation method: first medicinal liquid dividing potential drop dish is fixed under water dropper and covers, cover placement silica gel sealing ring under water dropper,
Water dropper is arranged under water dropper and covers, connect water dropper upper cover and water dropper lower cover makes it seal, to obtain final product) it is connected with drip irrigation, open and drip
Stirring paddle in filling, makes medicinal liquid be in dynamical state, adjusts the air pressure in drip irrigation and the opening time of electromagnetic valve, makes medicinal liquid from dripping
Tank enters in dripper device, adjusts medicinal liquid pressure and the opening time of electromagnetic valve, make drop pill weight at 300mg ± 10%,
The pill oozed by water dropper instills in condensed fluid, to obtain final product.
Claims (5)
1. the dripper device preparing large dripping pillar, it is characterised in that by dripper device upper cover (1), gim peg (2), medicinal liquid dividing potential drop
Dish (3), rubber cushion (4), dripper device lower cover (5), inner ring drip nozzle and outer ring drip nozzle (6), liquid medicine flow district (7) group
Becoming, the connected mode of all parts is: for liquid medicine flow between dripper device upper cover (1) and dripper device lower cover (5)
District (7), medicinal liquid dividing potential drop dish (3) is arranged on dripper device lower cover (5), under dripper device by gim peg (2)
The inside of the both sides of lid (5) is equipped with rubber cushion (4), and dripper device lower cover (5) is provided with inner ring drip nozzle and outer ring drip nozzle (6),
The outer rim of medicinal liquid dividing potential drop dish is in inner ring drip nozzle and the centre of outer ring drip nozzle (6), and is fixed on dripper device lower cover (5).
Dripper device the most according to claim 1, it is characterised in that dripper device is double or multiple rows of dripper device.
Dripper device the most according to claim 1, it is characterised in that dripper device upper cover (1), gim peg (2), medicinal liquid divides
Platen (3), dripper device lower cover (5), inner ring drip nozzle and outer ring drip nozzle (6) are stainless steel.
Dripper device the most according to claim 1, it is characterised in that the drop pill weight prepared by this device 100mg with
On.
Dripper device the most according to claim 1, it is characterised in that the aperture of the drip nozzle of each dripper device lower end be identical greatly
Little.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310727248.3A CN104042445B (en) | 2013-12-25 | 2013-12-25 | What a kind of more than the 100mg of preparation large dripping pillar was special has multiple rows of dripper device of dividing potential drop dish |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310727248.3A CN104042445B (en) | 2013-12-25 | 2013-12-25 | What a kind of more than the 100mg of preparation large dripping pillar was special has multiple rows of dripper device of dividing potential drop dish |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104042445A CN104042445A (en) | 2014-09-17 |
| CN104042445B true CN104042445B (en) | 2016-08-17 |
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| CN201310727248.3A Active CN104042445B (en) | 2013-12-25 | 2013-12-25 | What a kind of more than the 100mg of preparation large dripping pillar was special has multiple rows of dripper device of dividing potential drop dish |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109419628A (en) * | 2017-09-04 | 2019-03-05 | 烟台百药泰中药科技有限公司 | Porous seamless capsule and pill water dropper |
| CN111939837A (en) * | 2020-09-03 | 2020-11-17 | 润盈生物工程（上海）有限公司 | A water dropper device for liquid nitrogen pelletization |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660029A (en) * | 2004-08-10 | 2005-08-31 | 北京正大绿洲医药科技有限公司 | New technique for preparing drop pills and special dripper device |
| CN2824930Y (en) * | 2005-05-13 | 2006-10-11 | 北京长征天民高科技有限公司 | A dripper arrangement for preparation of dripping pill |
| CN101268986A (en) * | 2008-05-15 | 2008-09-24 | 闵金杆 | Apparatus for producing pills |
| CN201329032Y (en) * | 2008-12-24 | 2009-10-21 | 烟台开发区博森制药机械有限公司 | Constant pressure air blast micro drop pill dripper |
| CN203861592U (en) * | 2013-12-25 | 2014-10-08 | 江西济民可信药业有限公司 | Multi-row dripper device provided with pressure distributing disc and specially used for preparing big dropping pills of 100 mg or more |
-
2013
- 2013-12-25 CN CN201310727248.3A patent/CN104042445B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660029A (en) * | 2004-08-10 | 2005-08-31 | 北京正大绿洲医药科技有限公司 | New technique for preparing drop pills and special dripper device |
| CN2824930Y (en) * | 2005-05-13 | 2006-10-11 | 北京长征天民高科技有限公司 | A dripper arrangement for preparation of dripping pill |
| CN101268986A (en) * | 2008-05-15 | 2008-09-24 | 闵金杆 | Apparatus for producing pills |
| CN201329032Y (en) * | 2008-12-24 | 2009-10-21 | 烟台开发区博森制药机械有限公司 | Constant pressure air blast micro drop pill dripper |
| CN203861592U (en) * | 2013-12-25 | 2014-10-08 | 江西济民可信药业有限公司 | Multi-row dripper device provided with pressure distributing disc and specially used for preparing big dropping pills of 100 mg or more |
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| CN104042445A (en) | 2014-09-17 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160628 Address after: 336000 Yuanzhou Jiangxi Pharmaceutical Industrial Park Applicant after: Jiangxi Yaoming Yanghai Pharmaceutical Science and Technology Co., Ltd. Address before: 336000 Yuanzhou Jiangxi Pharmaceutical Industrial Park Applicant before: Jiangxi Jimin Kexin Pharmaceutical Co., Ltd. Applicant before: Jiangxi Jimin Kexin Group Co., Ltd. |
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Effective date of registration: 20170928 Address after: Pharmaceutical industry park, Yuanzhou District, Yichun, Jiangxi Patentee after: Jiangxi Jimin Kexin Pharmaceutical Co., Ltd. Address before: 336000 Yuanzhou Jiangxi Pharmaceutical Industrial Park Patentee before: Jiangxi Yaoming Yanghai Pharmaceutical Technology Co., Ltd. |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A multi row dripper device with partial pressure plate for preparation of large dropping pills over 100mg Effective date of registration: 20200817 Granted publication date: 20160817 Pledgee: China Merchants Bank Limited by Share Ltd. Nanchang branch Pledgor: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. Registration number: Y2020990000964 |
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| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220112 Granted publication date: 20160817 Pledgee: China Merchants Bank Limited by Share Ltd. Nanchang branch Pledgor: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. Registration number: Y2020990000964 |