CN1650950A - Traditional Chinese medicine for treating cow endo metritis - Google Patents
Traditional Chinese medicine for treating cow endo metritis Download PDFInfo
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- CN1650950A CN1650950A CN 200410073447 CN200410073447A CN1650950A CN 1650950 A CN1650950 A CN 1650950A CN 200410073447 CN200410073447 CN 200410073447 CN 200410073447 A CN200410073447 A CN 200410073447A CN 1650950 A CN1650950 A CN 1650950A
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- radix
- vegetable oil
- oleum
- chinese medicine
- salviae miltiorrhizae
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Abstract
A Chinese medicine in the form of perfusate for treating the endometritis of cow is prepared from red sage root, arnebia root, borneol and plant oil.
Description
Technical field
The present invention relates to a kind of Chinese medicine for animals, particularly combine, the medicine of treatment cattle endometritis with natural medicinal plants and natural organic matter.Medicine of the present invention is a kind of infusion liquid.
Background technology
Endometritis is the uterus of cause pathogeny imcrobe infection animal, causes that endometrium is inflamed, and performance hyperemia, blood stasis, edema, tissue permeability increase, mucosa injury comes off down to a series of pathological processes of suppurating, simultaneously normal physiological function forfeiture.Cattle endometritis is the important diseases that influences dairy development and economic benefit.At China's sickness rate is 10%～30%.This disease causes milch cow infertile, and the tire spacing increases, and milk yield descends.At present, endometritis is mainly treated with antibiotics and chemosynthesis antibacterials.But this type of medicine of life-time service causes pathogen to produce drug resistance, and therapeutic effect descends, and the residual health that directly threatens the people of milk Chinese medicine.
Summary of the invention
The invention provides a kind of medicine of the novel treatment cattle endometritis that combines with natural medicinal plants and natural organic matter, this medicine has inhibitory or killing effect and good antiinflammatory action to the pathogenic microorganism that causes inflammation, also should have the effect that promotes that the rheuminess thing is discharged, do not have Drug resistance, and can be in milk the residual material that is pernicious to people.
The present invention is combined by Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum and edible vegetable oil.Its more specifically prescription be:
Radix Salviae Miltiorrhizae 400g ± 10.0g Radix Arnebiae (Radix Lithospermi) 400g ± 10.0g Borneolum Syntheticum 2g ± 0.5g edible vegetable oil 1000ml.
The used edible vegetable oil of the present invention preferably adopts
EdibleOleum Helianthi.
Chinese medicinal preparation method of the present invention is: Radix Arnebiae (Radix Lithospermi) is put into container, add purified edible vegetable oil to Radix Arnebiae (Radix Lithospermi) is soaked into, soak diel, reheat to 120 ℃ was also kept 1 hour, leached edible vegetable oil then, promptly got the oil extract of Radix Arnebiae (Radix Lithospermi), Oleum Radix Arnebiae (Oleum Radix Lithospermi).Radix Salviae Miltiorrhizae is extracted with 95% dehydrated alcohol, reclaims ethanol then, the ethanol extract of Radix Salviae Miltiorrhizae.In Borneolum Syntheticum, grind to form behind the adding proper amount of edible vegetable oil and be colloid.Alcohol extract with Radix Salviae Miltiorrhizae adds in the Oleum Radix Arnebiae (Oleum Radix Lithospermi) again, heats the organic solvent volatilization that makes in the system after fully stirring, and adds to have ground to form colloidal Borneolum Syntheticum under stirring condition again.
Used edible vegetable oil can be any purified edible vegetable oil among the present invention, but preferably adopts Oleum Helianthi, because of rich in vitamin E in the Oleum Helianthi, and the recovery from illness that local use can be quickened to damage, the curative effect of raising medicine.
Find that through relevant test medicine of the present invention has anti-inflammation, regulates physiological function, characteristics safe in utilization, and the effect of enhancing human body immunity power, disease preventing and treating and raising livestock and poultry production performance is arranged.The medicine that method through adopting the present invention to provide makes also has stability preferably.And the present invention has with food homology, consubstantiality, with the characteristics of usefulness, is difficult for producing drug resistance, and drug residue free is easy to degraded, and environmental pollution is little, is comparatively safe medicine.The present invention can make full use of the advantage of China's Chinese herbal medicine resource, carries out the herbal control livestock and poultry, meets green Developing of Animal Industry direction.
The specific embodiment
Trial drug prescription of the present invention is:
Radix Salviae Miltiorrhizae 400g ± 10.0g Radix Arnebiae (Radix Lithospermi) 400g ± 10.0g Borneolum Syntheticum 2g ± 0.5g eats Oleum Helianthi 1000ml
Its specific practice is that Radix Arnebiae (Radix Lithospermi) is added in the purified sunflower oil, and oil is soaked into Radix Arnebiae (Radix Lithospermi), after soaking diel, system is heated to 120 ℃ and kept 1 hour again, leaches edible vegetable oil then, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi).Radix Salviae Miltiorrhizae is extracted with 95% dehydrated alcohol, reclaims ethanol then, the ethanol extract of Radix Salviae Miltiorrhizae.In Borneolum Syntheticum, grind to form after the adding proper amount of edible Oleum Helianthi and be colloid.Alcohol extract with Radix Salviae Miltiorrhizae adds in the Oleum Radix Arnebiae (Oleum Radix Lithospermi) again, heats the organic solvent volatilization that makes in the system after fully stirring, and adds to have ground to form colloidal Borneolum Syntheticum under stirring condition again.The tanshinol extract is added in the Oleum Radix Arnebiae (Oleum Radix Lithospermi), vigorous stirring, being heated to the organic solvent that makes about 80 ℃ in the system fully volatilizees, under brute force stirs, add the Borneolum Syntheticum that has ground to form colloidal state again, add sunflower oil again and be settled to 1000ml, make stable suspensoid, again through packing, sterilization is labelled, the lucifuge storage of packing back.
Above made medicine is carried out following test:
1) stability test
The medicine placement is tested after 2 years by the storage of drug storage standard, and its result shows that the physics and chemistry of medicine of the present invention and biological stability all keep well meeting " Chinese veterinary drug allusion quotation " (2000 editions two ones') relevant requirements.Therefore the present invention has stability preferably.
2) safety examination
Animal subject is 4 adult white rabbit, body weight 2.5～3kg (available from Lanzhou Inst. of Biological Products, Ministry of Public Health), and the clinical health inspection is all normal before the test.With aforementioned gained medicine for being subjected to the reagent thing.
Test method
Splash into to every day the experimental rabbits left eye and be subjected to reagent thing medicine of the present invention, right eye splashes into the preparation sunflower oil, each 0.1ml, force 10 seconds of rabbit eyes closed with hands, eye drip is 7 days continuously, behind eye drip first 6 hours with eye drip at every turn before the local response situation of observed and recorded eye, continue after the drug withdrawal to observe 7 days, mark respectively by related standards corneal, iris and conjunctiva, calculate meansigma methods, and compare with the contrast eye of same rabbit.
Result of the test
Result of the test shows that with behind the eye drip of the present invention, the eye conjunctiva has hyperemia slightly, and the comprehensive average mark of eye irritation slightly raises than the eye that drips sunflower oil with a rabbit offside, but still in non-irritating numerical range.The result shows that the present invention does not have zest to mucosa, is safe.
3) pharmacology test
A material and method
A.1 material
A.1 the medicine with the preceding method preparation is a trial drug; The contrast medicine is norfloxacin (powder, commercially available).
A.2 strain streptococcus pyogenes, streptococcus uberis, Streptococcus lactis (Lister) Lohnis 1909.554., staphylococcus aureus, escherichia coli, bacillus pyocyaneus.Every kind of each 3 strain of antibacterial, above strain is from the pathological material of disease of the clinical type endometritis of trouble of cattle farms, ground such as Lanzhou, Qingdao, Tianjin collection, through the strain of isolation identification preservation.
A.3 the common steamed beef soup of culture medium, M-H agar plate, 3% Sanguis caprae seu ovis M-H agar plate.
A.4 stainless-steel pipe external diameter 8mm, internal diameter 6mm, high 10mm.
The B method
B.1 cylinder plate method bacteriostatic test each bacterial strain that the blood inclined-plane is preserved is inoculated into respectively in the mid-37 ℃ of incubators of common steamed beef soup pipe and cultivates 20h, after smear for microscopic examination is pure, different strain is carried out the dilution (do trial test earlier and measure optimum diluting multiple) of different multiples.The bacterium liquid that dilution is good is added on the agar plate with sterilization suction pipe absorption 0.1ml that (plate must be fresh, Ying Suiyong is with doing), and with crooked L type Glass rod bacterium liquid is wipeed off immediately, then with little steel bowl after burning slightly on the alcohol burner, equidistant on agar surface vertically-arranged several, each tested medicinal liquid (do trial test earlier and measure optium concentration) and contrast medicinal liquid with variable concentrations adds in the steel bowl respectively then, thereafter change the plate lid into the potlery tile lid, horizontal is put into 37 ℃ of incubators and was cultivated 24 hours, take out with vernier caliper measurement antibacterial circle diameter (mm), every strain bacterium is repeated above-mentioned test and gets its average diameter of result several times for 3-4 time, is the antibacterial result of this medicine to this bacterial strain.
C criterion antibacterial circle diameter is a drug resistance less than 10mm, and 10-15mm is a medium sensitivity, and＞15mm is extremely sensitive.
D result
Test shows that this medicine all has certain fungistatic effect to 6 kinds of pathogen (18 strain), and is extremely sensitive to escherichia coli when drug level reaches 20mg/ml; To streptococcus pyogenes, streptococcus uberis, Streptococcus lactis (Lister) Lohnis 1909.554., staphylococcus aureus medium sensitivity; Fungistatic effect to bacillus pyocyaneus is poor slightly, is medium sensitivity when drug level reaches 80mg/ml.But all in all, medicine bacteriostasis of the present invention is not as norfloxacin.
4) clinical trial and clinical verification
A material and method
A.1 case
A.1.1 originate 1999～2002 years from cattle farm, Duan Jia beach, Lanzhou, Cao Tan cattle farm, Xi'an and five roads, Fengning, Hebei province county battalion raising dairy cattle base selects milch cow 112 examples of spontaneous generation endometritis; Cattle 155 examples of Wu Daoying township, Fengning, Hebei province county and Cao County, Shandong Province Yan Dian Lou town spontaneous generation endometritis; 267 examples altogether.
A.1.2 the kind milch cow is mainly Fresian, is that Xi Mentaer and the height of working as bamboo top are for the improvement cattle on a small quantity; Cattle has Luxi Yellow cattle, Mongolian cattle and cross-bred ox.
A.1.3 course of disease milch cow 112 examples, wherein 20～40 days 26 examples, 41～60 days 32 examples, 54 examples more than 61 days are the longest 185 days; Cattle 155 examples, 41～60 days 22 examples wherein, 61～90 days 35 examples, 98 examples more than 91 days are the longest 233 days.
A.1.4 1. diagnosis is seen and is had or not the rheuminess thing to discharge, poultry raiser, poultry master or artificial insemination person main suit see cow and discharge the rheuminess thing, see the vestige (oxtail, buttocks portion, hock joint filth have pus crusts) that stays after rheuminess thing or rheuminess thing are discharged during inspection, can tentatively determine to suffer from clinical type endometritis; 2. residing position, uterus, the shape of cornua uteri, the size in uterus, quality, contractile response are checked in examination per rectum, and ovary has or not corpus luteum, further judges the weight of inflammation; 3. carry out examination per vagina by prolapsus appliance, check the first transaction of a day's business degree, the color of cervical orifice and have or not pus to flow out, check the amount and the character of pus, determine the inflammation character and the order of severity.
A.1.5 267 examples of characteristic of disease treatment are clinical type endometritis, purulence endometritis 148 examples wherein, Catarrhal purulence endometritis 119 examples.
A.1.6 GP TH Niu Gongfen is 53 groups, and 1 group and 2 groups is medicine milch cow group of the present invention, and 3 groups for using the matched group of mycillin.
The B treatment
B.1 medicine medicine of the present invention is a pure Chinese medicine uterus perfusion oil suspending agent, and its preparation method sees before and states, lot number: 990515,000326,000723,010322,011108;
B.2 method of treatment is tested 1 group and 2 groups of uterus perfusion medicines of the present invention of test, each 25ml, and administration on the 3rd 1 time, 3 times was 1 course of treatment; Test 3 groups of each penicillin 2,400,000 units, streptomycin 1,000,000 units and be dissolved in uterus perfusion in the 30ml normal saline, once a day, 4 times was 1 course of treatment.2 courses of treatment, healing person did not use the other medicines treatment instead.
B.3 efficacy determination is divided into healing, improvement and invalid.Cure, clinical symptom disappearance is recovered normally to oestrus, and mucus is normal when oestrusing, and can carry out artificial insemination; Take a turn for the better, clinical symptom disappearance is recovered to oestrus, but mucus also has unusually when oestrusing, and still can not carry out artificial insemination; Invalid, clinical symptoms and uterus function all do not have and are clearly better.
Result of the test
Medicine of the present invention is treated altogether and is suffered from cattle 174 examples, cures 135 examples 1 course of treatment, and cure rate is cured 158 examples 77.59%, 2 course of treatment, cure rate 90.80%, and 2 examples that take a turn for the better, total effective rate 93.68% has 146 cow breeding back gestation, and being controlled the cattle pregnancy rate is 83.91%; In the 174 routine endometritis of being treated, milch cow 72 examples, cattle 102 examples, cure rate and total effective rate milch cow and cattle do not have difference, and the pregnancy rate milch cow is a little more than cattle, and this may be good relevant than cattle with management with the nutrition of milch cow.The mycillin matched group is treated 20 examples altogether, and cure 16 examples 2 courses of treatment altogether, cure rate 80%, and total effective rate 90% has 15 cow breeding back gestation, and being controlled the cattle pregnancy rate is 75%.Compare the effect of 2 kinds of Therapeutic Method, medicine of the present invention is the same substantially with pregnancy rate with cure rate, and all is higher than mycillin treatment group.
Afore-mentioned test shows: the medicine of being made up of Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum.Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, removing heat from blood repercussive curative effect, significant anti-inflammation is arranged, promote effects such as wound healing, free radical resisting and anti peroxidation of lipid; Also has relatively mild estrogen activity simultaneously.Radix Arnebiae (Radix Lithospermi), removing heat from blood and promoting blood circulation, heat-clearing and toxic substances removing, granulation promoting is put on flesh, skin ulcer is held back in dehumidifying, and traditional Chinese medical science tradition is used for the treatment of burn, soup wound, carbuncle sore and various chronic ulcer, and the effective ingredient shikonin in the Radix Arnebiae (Radix Lithospermi) all has the obvious suppression effect to escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Bacillus typhi and dysentery bacterium, its antiinflammatory action is similar to Phenylbutazone, and the effect of vasoconstrictive and inhibition capillary permeability is arranged.Borneolum Syntheticum, loose hot and suffocating fire-toxin, stimulate the menstrual flow, saturating meat, detumescence, parasite killing, pain relieving infections, smelly, the removing the necrotic tissue and promoting granulation of dirt eliminating, for treatment mucosal sites inflammation medicine commonly used, have antibiotic and antiinflammatory action, the zoopery prompting has inhibitory action to oozing out with inflammatory process such as tissue edema of liquid; Sunflower oil contains abundant vitamin E, and the recovery from illness that local use can be quickened to damage is clinically controlled dysentery, saturating carbuncle with it, and the report with its treatment endometritis is arranged separately.All medicines are collaborative in the side, brings into play antibacterial, antiinflammatory, detumescence, removing the necrotic tissue and promoting granulation, improve the effect of uterus blood circulation, promotion uterus functional recovery.The present invention is an oil suspending agent, and oil preparation has good flowability and penetration, helps medicine and scatters and play a role; Oil preparation can well disperse liposoluble constituent, so the present invention is a kind of long-acting dosage form.In medicine of the present invention, effective ingredient shikonin in the Radix Arnebiae (Radix Lithospermi) is dissolved in vegetable oil, effective ingredient in the Radix Salviae Miltiorrhizae and and Borneolum Syntheticum form attritive powder by special process and be dispersed in the oil, these medicines are difficult for being absorbed and discharging, increased action time at uterine mucosa, general water preparation can reduce administration number of times, has made things convenient for clinical practice.
Claims (5)
1, a kind of Chinese medicine of the treatment cattle endometritis of forming by Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum and edible vegetable oil.
2, Chinese medicine according to claim 1 is characterized in that its prescription is:
Radix Salviae Miltiorrhizae 400g ± 10.0g Radix Arnebiae (Radix Lithospermi) 400g ± 10.0g Borneolum Syntheticum 2g ± 0.5g
Edible oil vegetable oil 1000ml
3, Chinese medicine according to claim 2 is characterized in that its prescription edible vegetable oil is edible Oleum Helianthi.
4, according to claim 1 or 2 or 3 described preparation method of Chinese medicine, it is characterized in that Radix Arnebiae (Radix Lithospermi) is leached with edible vegetable oil, to leach oil again filters and obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi), with the Radix Salviae Miltiorrhizae ethanol extraction, boil off ethanol then and get the Radix Salviae Miltiorrhizae ethanol extract, in Borneolum Syntheticum, add edible vegetable oil and grind to form colloid, alcohol extract with Radix Salviae Miltiorrhizae adds the Oleum Radix Arnebiae (Oleum Radix Lithospermi) extract again, heat the organic solvent volatilization that makes in the system after fully stirring, adding has ground to form colloidal Borneolum Syntheticum under stirring condition again, adds the edible vegetable oil standardize solution again, carry out packing again, sterilization is labelled, packing.
5, method according to claim 4 is characterized in that used edible vegetable oil is Oleum Helianthi.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410073447 CN1268355C (en) | 2004-12-16 | 2004-12-16 | Traditional Chinese medicine for treating cow endo metritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410073447 CN1268355C (en) | 2004-12-16 | 2004-12-16 | Traditional Chinese medicine for treating cow endo metritis |
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| Publication Number | Publication Date |
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| CN1650950A true CN1650950A (en) | 2005-08-10 |
| CN1268355C CN1268355C (en) | 2006-08-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410073447 Expired - Fee Related CN1268355C (en) | 2004-12-16 | 2004-12-16 | Traditional Chinese medicine for treating cow endo metritis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1972343A1 (en) * | 2007-03-23 | 2008-09-24 | Navalis Nutraceuticals GmbH | Medicine containing lady's mantle, hemp tree for treating endometritis, vaginitis |
| CN104208194A (en) * | 2014-09-05 | 2014-12-17 | 江苏农林职业技术学院 | Traditional Chinese medicine composition for treating bovine endometritis, preparation method and application thereof |
| CN104825478A (en) * | 2015-04-14 | 2015-08-12 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition for treating milk cow endometritis, and perfusion liquid preparation method thereof |
| CN105193934A (en) * | 2015-10-21 | 2015-12-30 | 中国农业科学院兰州畜牧与兽药研究所 | Compound essential oil for treating endometritis of domestic animals and preparation method thereof |
-
2004
- 2004-12-16 CN CN 200410073447 patent/CN1268355C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1972343A1 (en) * | 2007-03-23 | 2008-09-24 | Navalis Nutraceuticals GmbH | Medicine containing lady's mantle, hemp tree for treating endometritis, vaginitis |
| EP2314304A1 (en) * | 2007-03-23 | 2011-04-27 | Navalis Nutraceuticals GmbH | Medicine containing lady's mantle, hemp tree for treating endometritis, vaginitis |
| CN104208194A (en) * | 2014-09-05 | 2014-12-17 | 江苏农林职业技术学院 | Traditional Chinese medicine composition for treating bovine endometritis, preparation method and application thereof |
| CN104825478A (en) * | 2015-04-14 | 2015-08-12 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition for treating milk cow endometritis, and perfusion liquid preparation method thereof |
| CN104825478B (en) * | 2015-04-14 | 2017-08-29 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of preparation method for being used to treat the pharmaceutical composition and its perfusion liquid of cow endometritis |
| CN105193934A (en) * | 2015-10-21 | 2015-12-30 | 中国农业科学院兰州畜牧与兽药研究所 | Compound essential oil for treating endometritis of domestic animals and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1268355C (en) | 2006-08-09 |
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Granted publication date: 20060809 Termination date: 20101216 |