CN1634541A - Medicine for treating fatigue syndrome and preventing presenility, and preparation method thereof - Google Patents
Medicine for treating fatigue syndrome and preventing presenility, and preparation method thereof Download PDFInfo
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- CN1634541A CN1634541A CN 200410079539 CN200410079539A CN1634541A CN 1634541 A CN1634541 A CN 1634541A CN 200410079539 CN200410079539 CN 200410079539 CN 200410079539 A CN200410079539 A CN 200410079539A CN 1634541 A CN1634541 A CN 1634541A
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Abstract
The invention discloses a medicine for treating fatigue syndrome and preventing presenility, which is prepared from emblic leafflower fruit, gynostemma pentaphylla, and glossy ganoderma a finite of weight ratio proportion. The medicine can be prepared into any of the conventional oral administration dosage.
Description
Technical field
The present invention relates to the Chinese herbal medicine is the Chinese patent medicine of feedstock production, more particularly, relates to a kind of medicine for the treatment of fatigue syndrome, preventing senilism.The invention still further relates to the preparation method of this medicine.
Background technology
Theory of Chinese medical science is thought, fatigue syndrome and senilism are because due to the asthenia of both the spleen and kidney, QI and blood deficiency, disarmony between the heart and kidney, decline of the fire from the gate of life, clinical manifestation be asthenic body, soreness of the waist and knees, insomnia and dreamful sleep, Light-headedness, appearance dark and gloomy, early give birth to poliosis or alopecia, be subject to disease such as exopathogen.Doctor trained in Western medicine then descends this class because of the immune function that chronic fatigue causes, the situation of body function imbalance is referred to as sub-health state, thinks that a lot of diseases, such as hypertension, diabetes, cardiac cerebral arteriosclerosis etc. are all relevant therewith.
Domestic and international application often lacks specific aim in this type of treatment of diseases medicine at present, owing to cost an arm and a leg, the patient can't adhere to long-term prescription, makes that therapeutic effect is difficult to keep simultaneously.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of and treats fatigue syndrome, can remove human free radical effectively, the human body immunity improving function, eliminate a series of comprehensive untoward reaction that the confirmed fatigue accumulation brings, the medicine that prevents senilism.
Another technical problem to be solved by this invention is to provide a kind of preparation method of this medicine.
Medicament selection Fructus Phyllanthi of the present invention, Herb Gynostemmae Pentaphylli and Ganoderma make up, and make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat fatigue syndrome, prevent senilism.Wherein select for use Fructus Phyllanthi to be because Fructus Phyllanthi contains abundant vitamin and trace element, have the effect of generally acknowledged anti-cancer, defying age and enhancing immune function of human body.Record in " Chinese medicine voluminous dictionary ": Fructus Phyllanthi have be good for the stomach, help digestion, lung moistening, promote the production of body fluid, effects such as astringing to arrest diarrhea, resolving heat and reducing pathogenic fire, detoxifcation, allaying tiredness.Indigo plant and Ganoderma as selecting to twist, be because Herb Gynostemmae Pentaphylli has obvious inhibitory action to the propagation of multiple cancerous cell, simultaneously human body there are effects such as nourishing, calmness, hypnosis, antitonic, promotion appetite, blood fat reducing, cholesterol reducing, transaminase lowering and slow down aging, are used for the treatment of cardiovascular disease, hepatitis B, liver cirrhosis, migraine, poliosis, insomnia and multiple cancer clinically.Ganoderma can consolidate tonification, supporing yang strong, can relieving asthma, cough-relieving, eliminate the phlegm, and has the effect of blood sugar lowering, blood fat reducing and blood pressure lowering, can effectively improve body vigor and anti-adversity ability.
In order to reach better therapeutic, medicine of the present invention also makes up with the Radix Astragali and Fructus Schisandrae Chinensis.This is because the Radix Astragali can strengthening the body resistance, and Fructus Schisandrae Chinensis has the effect of excited strong, nourishing, convergence, is used to have strengthened curative effect.
The consumption of medicine components of the present invention is also summed up through a large amount of clinical practices of inventor and is drawn, and the each component consumption is for all having better curative effect in the following weight parts scope:
3～5 parts of Fructus Phyllanthis, 3～5 parts of Herb Gynostemmae Pentaphylli, 2～4 parts of Ganodermas.
Be preferably: 5 parts of Fructus Phyllanthis, 3 parts of Herb Gynostemmae Pentaphylli, 2 parts of Ganodermas.
Medicine each component consumption of the present invention can also be 3～5 parts of Fructus Phyllanthis, 3～5 parts of Herb Gynostemmae Pentaphylli, 2～4 parts of Ganodermas, 1.5～5 parts of the Radixs Astragali, 1～3 part of Fructus Schisandrae Chinensis.
Be preferably: 3 parts of Fructus Phyllanthis, 2 parts of Herb Gynostemmae Pentaphylli, 1.5 parts of Ganodermas, 2 parts of the Radixs Astragali, 1.5 parts of Fructus Schisandrae Chinensis.
The preparation method of medicine of the present invention is as follows:
(1) take by weighing each crude drug Fructus Phyllanthi, Herb Gynostemmae Pentaphylli and Ganoderma by described weight proportion, standby;
(2) Fructus Phyllanthi is cleaned, is squeezed the juice, concentrating under reduced pressure becomes extractum, drying, Fructus Phyllanthi extract;
(3) Herb Gynostemmae Pentaphylli is decocted with water three times, each amount of water was not advisable to have powder, merge three times decoction liquor, filter to get filtrate, it is 1.30 extractum that filtrate is condensed into proportion, and the ethanol that adds 2～4 times of amounts 90%～95% carries out precipitate with ethanol, reclaims ethanol and concentrates, dry under 50 ℃～80 ℃, get the gypenoside extract;
(4) Ganoderma of described weight proportion is pulverized with pulverizer, add 60%～80% ethanol and carry out the reflux, extract, secondary, merge extractive liquid, reclaims the ethanol in the extracting solution, is concentrated into proportion and is 1.30 extractum 1; The reuse clean water extracts once, is concentrated into proportion and is 1.30 extractum 2, merges extractum 1 and extractum 2,50 ℃～80 ℃ dry down, Ganoderma extract;
(5) gains of combining step (2), (3) and (4) are ground into powder with it, just have been prepared into the active constituent of medicine of the present invention.
If also add the Radix Astragali and Fructus Schisandrae Chinensis, the preparation method of medicine of the present invention is as follows:
(1) take by weighing each crude drug Fructus Phyllanthi, Herb Gynostemmae Pentaphylli, Ganoderma, the Radix Astragali and Fructus Schisandrae Chinensis by described weight proportion, standby;
(2) Fructus Phyllanthi is cleaned, is squeezed the juice, concentrating under reduced pressure becomes extractum, drying, Fructus Phyllanthi extract;
(3) Herb Gynostemmae Pentaphylli is decocted with water three times, each amount of water was not advisable to have powder, merge three times decoction liquor, filter to get filtrate, it is 1.30 extractum that filtrate is condensed into proportion, and the ethanol that adds 2～4 times of amounts 90%～95% carries out precipitate with ethanol, reclaims ethanol and concentrates, dry under 50 ℃～80 ℃, get the gypenoside extract;
(4) Ganoderma, the Radix Astragali and the Fructus Schisandrae Chinensis of described weight proportion are pulverized the back mix homogeneously with pulverizer respectively, add 60%～80% ethanol and carry out the reflux, extract, secondary, merge extractive liquid, reclaims the ethanol in the extracting solution, is concentrated into proportion and is 1.30 extractum 1; The reuse clean water extracts once, is concentrated into proportion and is 1.30 extractum 2, merges extractum 1 and extractum 2, at 50 ℃～80 ℃ dry down dry extracts;
(5) gains of combining step (2), (3) and (4) are ground into powder with it, just have been prepared into the active constituent of medicine of the present invention.
The active constituent of medicine of the present invention can add the conventional adjuvant for preparing different dosage form, makes corresponding peroral dosage form, as tablet, soft capsule or hard capsule.
Medicine of the present invention has the effect of strengthening the body resistance, anti-disease, anti-aging, can treat fatigue syndrome, prevent senilism.Find that through experiment this medicine also has the auxiliary treatment effect to acquired immune deficiency syndrome (AIDS).
The specific embodiment
Below routine by experiment beneficial effect of further setting forth medicine of the present invention.
The clinical observation of [test example 1] Drug therapy fatigue syndrome of the present invention and senilism
1. physical data
Accept out-patient's totally 83 examples for medical treatment, wherein male 52 examples, women 31 examples, men and women's ratio is 1.7: 1.20～30 years old 16 age example, 31 years old～40 years old 21 example, 41 years old～50 years old 41 example, 5 examples more than 51 years old.
2. diagnostic criteria
(1) tcm diagnosis standard
By theory of Chinese medical science, fatigue syndrome and senilism are summed up as asthenia of both the spleen and kidney, QI and blood deficiency, and disarmony between the heart and kidney, gate of vitality's fire is assisted.Clinical manifestation is physical weakness, soreness of the waist and knees, moving then asthma, insomnia and dreamful sleep, spontaneous perspiration, unable, Light-headedness, spermatorrhea, seminal emission, dim complexion, dull-looking, early gives birth to poliosis or alopecia, xerosis cutis; Then irregular menstruation or amenorrhea of women, facial colour spot, the few tongue of red tongue, deep-thready pulse.
(2) Western medicine diagnose standard
Because of causing the symptom of immunity of organisms decline, functional disorder, chronic fatigue is called sub-health state with many.Clinical data shows, diseases such as hypertension, hyperlipidemia, diabetes, cardiac cerebral arteriosclerosis, even cancer is all relevant with sub-health state.
3. Therapeutic Method
Anthology invention medicinal tablet, every 0.5g, every day three times, each 2, two weeks is a course of treatment, according to 2～4 courses of treatment of different symptoms logotype.
4. efficacy determination
Produce effects: symptom is eliminated, and it is normal that various vital signs and physiological function recover, and observed 1 year, do not have recurrence.
Take a turn for the better: most of symptom is eliminated, and various vital signs and physiological function recover to some extent, but organic disease still need be treated.
Invalid: as not reach improvement standard person.
5. therapeutic outcome (see Table 1, table 2)
Table 1 treatment back observation of curative effect
| Treatment time (my god) | Produce effects | Effectively | Invalid | Effective percentage (%) | |||
| The example number | Obvious effective rate (%) | The example number | Effective percentage (%) | The example number | Inefficiency (%) | ||
| ??7 | ??0 | ??0 | ??15 | ??17.8 | ??69 | ??82.2 | ??17.8 |
| ????10 | ????10 | ????10.7 | ????21 | ????25 | ????53 | ????63.4 | ????35.7 |
| ????14 | ????35 | ????41.6 | ????16 | ????19 | ????32 | ????39.4 | ????60.6 |
| ????30 | ????61 | ????72.6 | ????11 | ????13 | ????12 | ????14.4 | ????85.6 |
| ????50 | ????62 | ????73.8 | ????13 | ????15.4 | ????9 | ????10.8 | ????89.2 |
| ????60 | ????71 | ????84.5 | ????5 | ????6 | ????8 | ????9.5 | ????90.5 |
Table 2 is symptom improvement situation after treating February
| Symptom | Sexual disorder | Hypertension, hyperlipemia | Hoariness and alopecia | Diabetes | Fatigue syndrome | Insomnia and dreamful sleep is dizzy | The mottle chloasma |
| Before the treatment | ????36 | ????40 | ????21 | ????10 | ????45 | ????37 | ????25 |
| After the treatment | ????5 | ????4 | ????7 | ????3 | ????5 | ????6 | ????5 |
| Total effective rate (%) | ????96.1 | ????90 | ????66.7 | ????70 | ????88.9 | ????83.8 | ????80 |
In a word, in bimestrial clinical treatment, treat 84 examples, produce effects 71 examples as a result, 5 examples that take a turn for the better, invalid 8 examples, total effective rate 90.5%.
The observation of curative effect of [experimental example 2] medicine auxiliary treatment AIDS of the present invention
Medicine: medicine capsule 0.5g/ grain of the present invention, dideoxycytidine and interleukin.
Therapeutic Method: adopt counter point, patient's 12 examples, sick time is the shortest 8 months, the longest 3 years 06 months, the oldest 48 years old, minimum 36 years old.Select illly more than 2 years and complication is many, 6 examples of age more than 40 years old are organized as treatment, all the other 6 examples are matched group.The treatment group is oral with medicine capsule of the present invention and each 2 of dideoxycytidines, every day 3 times; Respectively 2 of dideoxycytidine and interleukin of matched group, every day 3 times.Treat after 6 months, comparing result sees Table 3.
Table 3 acquired immune deficiency syndrome (AIDS) auxiliary treatment Comparison of therapeutic after 6 months
| Group | General symptom | Respiratory symptom | Symptom of digestive tract | Neurological symptom | Skin and mucosal injury | Dead |
| Matched group | Persistent fever, weakness | Still have cough, chest pain | Anorexia, nauseating, vomiting | Still have headache, dizzy symptom | Herpes, the oral cavity is pharyngeal festers | ??1 |
| The treatment group | Treatment is generated heat after January and is disappeared, and spirit takes a turn for the better | Idol has cough, chest pain to disappear | Appetite increases, idol has nauseating | The slight vital sign of symptom obviously improves | Part skin, herpes, the pharyngeal improvement of festering in oral cavity | ??0 |
Confirm by above-mentioned contrast therapy, medicine of the present invention is obvious to the auxiliary treatment effect of acquired immune deficiency syndrome (AIDS), it is by adjustment and improve body's immunological function, can reduce the side effect of dideoxycytidine to health, thereby strengthen patient's function, appetite stimulator, mitigation symptoms, raising medicine therapeutic effect, improve patient's life quality, indicating good medical prospect.
Further specify the preparation method of medicine of the present invention by the following examples.
The capsule preparation of [embodiment 1] medicine of the present invention
(1) 3 kilograms of weighting raw materials Fructus Phyllanthis, 2 kilograms of Herb Gynostemmae Pentaphylli, 1.5 kilograms of Ganodermas, 2 kilograms of the Radixs Astragali and Fructus Schisandrae Chinensis are 1.5 kilograms, and be standby;
(2) Fructus Phyllanthi is cleaned, is squeezed the juice, concentrating under reduced pressure becomes extractum, drying, Fructus Phyllanthi extract;
(3) Herb Gynostemmae Pentaphylli is decocted with water three times, each amount of water was not advisable to have powder, merge three times decoction liquor, filter to get filtrate, it is 1.30 extractum that filtrate is condensed into proportion, and the ethanol that adds triplication 90%～95% carries out precipitate with ethanol, reclaims ethanol and concentrates, dry under 50 ℃～80 ℃, get the gypenoside extract;
(4) Ganoderma, the Radix Astragali and Fructus Schisandrae Chinensis are pulverized with pulverizer respectively, mix homogeneously adds 60%～80% ethanol and carries out the reflux, extract, secondary, and merge extractive liquid, reclaims the ethanol in the extracting solution, is concentrated into proportion and is 1.30 extractum; The reuse clean water extracts once, is concentrated into proportion and is 1.30 extractum, merges extractum twice, 50 ℃～80 ℃ dry down, dry extract;
(5) gains of combining step (2), (3) and (4) are ground into powder with it, and pack into soft capsule or hard capsule get final product.
The preparation tablets of [embodiment 2] medicine of the present invention
(1) take by weighing 1.5 kilograms of 3 kilograms of Fructus Phyllanthis, 2 kilograms of Herb Gynostemmae Pentaphylli, 1.5 kilograms of Ganodermas, 2 kilograms of the Radixs Astragali and Fructus Schisandrae Chinensis, standby;
(2) Fructus Phyllanthi is cleaned, is squeezed the juice, concentrating under reduced pressure becomes extractum, drying, Fructus Phyllanthi extract;
(3) Herb Gynostemmae Pentaphylli is decocted with water three times, each amount of water was not advisable to have powder, merge three times decoction liquor, filter to get filtrate, it is 1.30 extractum that filtrate is condensed into proportion, and the ethanol that adds triplication 90%～95% carries out precipitate with ethanol, reclaims ethanol and concentrates, dry under 50 ℃～80 ℃, get the gypenoside extract;
(4) Ganoderma, the Radix Astragali and Fructus Schisandrae Chinensis are pulverized the back mix homogeneously with pulverizer respectively, add 60%～80% ethanol and carry out the reflux, extract, secondary, merge extractive liquid, reclaims the ethanol in the extracting solution, is concentrated into proportion and is 1.30 extractum 1; The reuse clean water extracts once, is concentrated into proportion and is 1.30 extractum 2, merges extractum 1 and extractum 2,50 ℃～80 ℃ dry down, dry extract;
(5) gains of combining step (2), (3) and (4) are ground into powder with it, add the adjuvant compacting in flakes.
Needed various conventional adjuvants when the active constituent of medicine of the present invention can also add the preparation different dosage form, be prepared into any peroral dosage form commonly used as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as pill, powder, oral liquid etc.The present invention simultaneously also is not limited to the above-mentioned specific embodiment, no matter extracting method is all to adopt ethanol extraction or all adopt water extract-alcohol precipitation, or the extract of directly buying single raw material makes up, and all drops in protection scope of the present invention.
Claims (8)
1, a kind of medicine for the treatment of fatigue syndrome, preventing senilism is characterized in that it mainly is to be made by following raw medicaments in portion by weight: 3～5 parts of Fructus Phyllanthis, 3～5 parts of Herb Gynostemmae Pentaphylli, 2～4 parts of Ganodermas.
2, medicine according to claim 1, wherein the consumption of each raw material is: 5 parts of Fructus Phyllanthis, 3 parts of Herb Gynostemmae Pentaphylli, 2 parts of Ganodermas.
3, according to the preparation method of claim 1 or 2 described medicines, it may further comprise the steps:
(1) take by weighing each crude drug Fructus Phyllanthi, Herb Gynostemmae Pentaphylli and Ganoderma by described weight proportion, standby;
(2) Fructus Phyllanthi is cleaned, is squeezed the juice, concentrating under reduced pressure becomes extractum, drying, Fructus Phyllanthi extract;
(3) Herb Gynostemmae Pentaphylli is decocted with water three times, each amount of water was not advisable to have powder, merge three times decoction liquor, filter to get filtrate, it is 1.30 extractum that filtrate is condensed into proportion, and the ethanol that adds 2～4 times of amounts 90%～95% carries out precipitate with ethanol, reclaims ethanol and concentrates, dry under 50 ℃～80 ℃, get the gypenoside extract;
(4) Ganoderma of described weight proportion is pulverized with pulverizer, add 60%～80% ethanol and carry out the reflux, extract, secondary, merge extractive liquid, reclaims the ethanol in the extracting solution, is concentrated into proportion and is 1.30 extractum 1; The reuse clean water extracts once, is concentrated into proportion and is 1.30 extractum 2, merges extractum 1 and extractum 2,50 ℃～80 ℃ dry down, Ganoderma extract;
(5) gains of combining step (2), (3) and (4) are ground into powder with it, just have been prepared into the active constituent of medicine of the present invention.
4. medicine according to claim 1, wherein crude drug also has: 1.5～5 parts of the Radixs Astragali, 1～3 part of Fructus Schisandrae Chinensis.
5. medicine according to claim 4, wherein the consumption of each component is: 3 parts of Fructus Phyllanthis, 2 parts of Herb Gynostemmae Pentaphylli, 1.5 parts of Ganodermas, 2 parts of the Radixs Astragali, 1.5 parts of Fructus Schisandrae Chinensis.
6. according to the preparation method of claim 4 or 5 described medicines, it may further comprise the steps:
(1) take by weighing each crude drug Fructus Phyllanthi, Herb Gynostemmae Pentaphylli, Ganoderma, the Radix Astragali and Fructus Schisandrae Chinensis by described weight proportion, standby;
(2) Fructus Phyllanthi is cleaned, is squeezed the juice, concentrating under reduced pressure becomes extractum, drying, Fructus Phyllanthi extract;
(3) Herb Gynostemmae Pentaphylli is decocted with water three times, each amount of water was not advisable to have powder, merge three times decoction liquor, filter to get filtrate, it is 1.30 extractum that filtrate is condensed into proportion, and the ethanol that adds 2～4 times of amounts 90%～95% carries out precipitate with ethanol, reclaims ethanol and concentrates, dry under 50 ℃～80 ℃, get the gypenoside extract;
(4) Ganoderma, the Radix Astragali and the Fructus Schisandrae Chinensis of described weight proportion are pulverized the back mix homogeneously with pulverizer respectively, add 60%～80% ethanol and carry out the reflux, extract, secondary, merge extractive liquid, reclaims the ethanol in the extracting solution, is concentrated into proportion and is 1.30 extractum 1; The reuse clean water extracts once, is concentrated into proportion and is 1.30 extractum, merges extractum 1 and extractum 2,50 ℃～80 ℃ dry down, dry extract;
(5) gains of combining step (2), (3) and (4) are ground into powder with it, just have been prepared into the active constituent of medicine of the present invention.
7. according to the preparation method of the described medicine of claim 6, wherein the active constituent that step (5) is made mixes tabletting with tablet adjuvant commonly used.
8. according to the preparation method of the described medicine of claim 6, pack into soft capsule or hard capsule of the active constituent that step (5) is made wherein.
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| CN 200410079539 CN1269493C (en) | 2004-11-01 | 2004-11-01 | Medicine for treating fatigue syndrome and preventing presenility, and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054909A (en) * | 2013-02-04 | 2013-04-24 | 福建仙芝楼生物科技有限公司 | Capsule for alleviating physical fatigue and preparation method thereof |
| CN104705634A (en) * | 2013-12-11 | 2015-06-17 | 余邦 | Lucid ganoderma healthcare product for protecting health |
| CN110960624A (en) * | 2019-12-02 | 2020-04-07 | 江苏康缘药业股份有限公司 | Anti-fatigue composition and preparation method thereof |
| CN115192651A (en) * | 2022-05-12 | 2022-10-18 | 海南医学院 | Li medicine composition and Li medicine preparation for hyperlipidemia and preparation method and application thereof |
-
2004
- 2004-11-01 CN CN 200410079539 patent/CN1269493C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054909A (en) * | 2013-02-04 | 2013-04-24 | 福建仙芝楼生物科技有限公司 | Capsule for alleviating physical fatigue and preparation method thereof |
| CN103054909B (en) * | 2013-02-04 | 2014-09-10 | 福建仙芝楼生物科技有限公司 | Capsule for alleviating physical fatigue and preparation method thereof |
| CN104705634A (en) * | 2013-12-11 | 2015-06-17 | 余邦 | Lucid ganoderma healthcare product for protecting health |
| CN110960624A (en) * | 2019-12-02 | 2020-04-07 | 江苏康缘药业股份有限公司 | Anti-fatigue composition and preparation method thereof |
| CN115192651A (en) * | 2022-05-12 | 2022-10-18 | 海南医学院 | Li medicine composition and Li medicine preparation for hyperlipidemia and preparation method and application thereof |
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| CN1269493C (en) | 2006-08-16 |
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