CN1634530A - Modified Huoxiang Zhengqi drop pill and its preparation method - Google Patents
Modified Huoxiang Zhengqi drop pill and its preparation method Download PDFInfo
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Abstract
The invention relates to a modified Huoxiang Zhengqi drop pill and its preparation method, wherein the drop pill is prepared from patchouli, sweet basil, dahurian angelica root, white atractylodes rhizome, dried orange peel, pinellia tuber, magnolia bark, poria cocos wolf through mixing with substrate, instilling immiscible condensate liquids, converging condensation into drop pills. The advantages include high biological availability, better constancy, reduced process flow and lowered production costs.
Description
Technical field: the present invention relates to a kind of Add Flavor Healthy Tendency Drop Pill of Wrinkled Giant Hyssop Preparation and Preparation Method, belong to the field of drug technique.
Technical background: huoxiang zhengqi powder is Song dynasty " formulary of peaceful benevolent dispensary " contained preparation, tool induce sweat dampness dissipating, QI regulating and in merit, be mainly used to the card of affection of exogenous wind-cold, internal injury humidity hysteresis, go through the clinical practice of nearly one thousand years, determined curative effect.Can also be used for treatment of diseases such as asthma of cold-type, drowsiness, insomnia, diabetes, hepatitis B.Medicamental pulverata residued between slot, tongue when but powder was taken, and was difficult to swallow, and felt more uncomfortable, and can't use immediately, must get and take after the Rhizoma Zingiberis Recens Fructus Jujubae is fried in shallow oil soup, very inconvenience.So in succession it has been carried out a large amount of research from many so far pharmacy workers of 1950's end.As application number is " 03135284.7 ", name is called the patent application of " a kind of new method of HUOXIANG ZHENGQI JIAONANG preparation ", and application number is " 200310122427.0 ", name is called the patent application of " a kind of preparation method of 'Jia Wei Huo Xiang ' soft capsule and method of quality control ", though the product that obtains has certain curative effect, but still have a lot of problems: the content of capsule bonding easily is rotten, and medicine stability is not good; And can soft capsule produce bioavailability preferably, depend on oral after disintegrate in time, its cyst membrane is with compositions such as a certain proportion of gelatin, G ﹠ Ws, domestic expert generally believes that the character of its main component gelatin all seems very important to formability, the dissolubility of softgel shell, but with the gelatin is the soft capsule of glue shell Main Ingredients and Appearance, causes that in storage period disintegration, disqualification rate was high because gelatin is with the passing of time aging; Soft capsule causes capsule deformation and seepage because of the moisture that absorbs in the medicinal liquid; These problems have influenced the curative effect of our product to a great extent.Huoxiang zhengqi powder is classical ancient prescription, is the treasure that ancestors stay, and we should inherit and develop the characteristic of Chinese medicine, thus seek a kind ofly have excellent curative, mouthfeel is good, technology rationally feasible formulation products satisfies the demand in market.
Summary of the invention: the object of the invention is to provide a kind of Add Flavor Healthy Tendency Drop Pill of Wrinkled Giant Hyssop Preparation and Preparation Method, and product stability is good, and long term store also can keep curative effect, enlarges the application of classics side, satisfies market demand.
The present invention constitutes like this: the extract that calculates by Herba Pogostemonis 326.8g, Folium Perillae 108.9g, Radix Angelicae Dahuricae 108.9g, Rhizoma Atractylodis Macrocephalae (parched) 217.9g, Pericarpium Citri Reticulatae 217.9g, Rhizoma Pinelliae Preparata 217.9g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 217.9g, Poria 108.9g, Radix Platycodonis 217.9g, Radix Glycyrrhizae 217.9g and Pericarpium Arecae 108.9g or corresponding weight according to weight is prepared from.The preparation method of health restoring agastache dripping pill preparation of the present invention is: get Cortex Magnoliae Officinalis with 60% ethanol extraction three times, and each 1 hour, filter, merging filtrate reclaims ethanol, and being concentrated into relative density is the clear paste I of 1.15 (80 ℃); Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Dahuricae vapor distillation extract volatile oil, and the aqueous solution after the distillation filters, and device is collected in addition; The medicinal residues and the Rhizoma Pinelliae, Poria, Radix Platycodonis, Radix Glycyrrhizae, Pericarpium Arecae, Rhizoma Zingiberis Recens 32.7g and Fructus Jujubae 54.5g decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, merge with above-mentioned aqueous solution, filter, it is 1.12 clear paste that filtrate is concentrated into relative density, centrifugal, supernatant concentration to relative density is the clear paste II of 1.15 (80 ℃); Merge clear paste I and II, be concentrated into the thick paste that relative density is 1.30-1.35, drying under reduced pressure is ground into fine powder, gets drug extract, the refabrication drop pill.Say the preparation method of health restoring agastache dripping pill preparation of the present invention accurately: the thing extract of getting it filled, join in the molten matrix, reuse dropping preparation method pill is condensed in the coolant and removes coolant behind the ball, dry and drop pill.
The selection process of the preparation method of health restoring agastache dripping pill preparation of the present invention is: the thing extract of getting it filled, with the Macrogol 4000 is substrate, according to medicine: the part by weight of substrate=1: 3 adds Macrogol 4000, mixing, the employing internal diameter is 4.0mm, external diameter is the dropper of 6.0mm, drip 70 ℃ of system temperature, dripping speed is 20～30d/min, dripping distance is 6cm, splash in the long cooling column of 140cm, be liquid coolant again with the methyl-silicone oil, the cooling of employing gradient: the Temperature Distribution of gradient liquid coolant is 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃, pill, promptly.
Among the present invention: Herba Pogostemonis can hot dispersing wind and cold, evacuates the pathogenic factor in the exterior heat-damp in summer, again can removing dampness by means of aromatics, and the spleen and stomach regulating is monarch drug in the side; The hot warm pulvis aromaticus wind of compatibility, external-open fur are let out the logical space between skin and muscles of lung, in open septum pectorale Folium Perillae and the hot dispersing wind and cold that the stomach removing dampness stagnates of being amusing and reach skin outward, descending the intestines and stomach is dispeled the Radix Angelicae Dahuricae of turbid damp and is evacuated pathogenic factor in the exterior; Cortex Magnoliae Officinalis that compatibility the spleen strengthening and damp drying, alleviating distention in middle-JIAOization stagnate and circulation of qi promoting intestinal stasis relieving, alleviating distention in middle-JIAO remove the turbid Pericarpium Arecae of damp eliminating that expands, and the two removes distension and fullness of the chest and abdomen altogether; The Radix Platycodonis lung qi dispersing removes expectorant; The Rhizoma Pinelliae, Pericarpium Citri Reticulatae regulating the stomach and sending down the abnormal ascending QI remove nausea and vomiting; Rhizoma Atractylodis, Poria invigorating the spleen and regulating the stomach, dispelling dampness and promoting diuresis are to help the fortune function of taste; Radix Glycyrrhizae, Fructus Jujubae, Rhizoma Zingiberis Recens harmonizing yingfen and weifen.
Compared with prior art, the applicant with medicine and substrate mixing after, splash in the not miscible condensed fluid, shrink and to be condensed into drop pill, bioavailability height, good stability.The applicant finds that in development the Herba Pogostemonis among the we, Folium Perillae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae contain a large amount of volatile oil, if the too high then effective ingredient of melt temperature is easy to scatter and disappear when dripping system, if it is low excessively to drip the system temperature, molding is difficulty relatively again; And the roundness of this product is very poor, finds to drip apart from being the main cause that causes the roundness difference by a large amount of experiments, drips apart from too small, and dropping liquid has little time to shrink, and the ball type is rounding not; Drip apart from excessive, drop becomes flat or is fallen to loose because of action of gravity to produce piller easily; And roundness is to weigh the important indicator of drop pill quality, so after having carried out a large amount of research work, established the optimum condition that comprises the preparation preparation drop pill of the present invention that drips distance: with the Macrogol 4000 is substrate, according to medicine: the part by weight of substrate=1: 3 adds Macrogol 4000, mixing, the employing internal diameter is 4.0mm, external diameter is the dropper of 6.0mm, drip 70 ℃ of system temperature, dripping speed is 20～30d/min, dripping distance is 6cm, splash in the long cooling column of 140cm, be liquid coolant again with the methyl-silicone oil, adopt the gradient cooling: the Temperature Distribution of gradient liquid coolant is 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃.The present invention has reduced technological process when having improved bioavailability, reduced production cost, has improved roundness, has improved the heavy qualification rate of ball, and it is good that preparation process is particularly dripped the system process operation, and the convenience of carrying and taking also strengthens greatly.
The applicant carries out a series of experiments, and is effectively controlled to confirm method provided by the invention, the preparation good effect.
Experimental example 1 pharmacodynamic study
(1) to the therapeutical effect of energy-stagnation stomachache.
1. analgesic activity: hot plate temperature is (55 ± 0.5) ℃.Selecting the threshold of pain (licking metapedes) is 30 of the female mices of 10～30s, and body weight (18～22) g is divided into 3 groups at random: JIAWEI HUOXIANG ZHENGQI WAN group, JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group and drop pill group of the present invention.The threshold of pain of its average before as administration got in the administration before measurement threshold of pain 2 times.JIAWEI HUOXIANG ZHENGQI WAN group, JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group and drop pill group mice of the present invention are distinguished gastric infusion JIAWEI HUOXIANG ZHENGQI WAN, JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group and drop pill of the present invention then, and dosage is 10g/kg.Measure mice administration 60,80, the threshold of pain during 100min with hot plate method.
Hot plate method is caused pain mice analgesic test result
The threshold of pain
Group 0min 60min 80min 100min
JIAWEI HUOXIANG ZHENGQI WAN group 23.8 ± 4.1 31.8 ± 14.2 45.3 ± 14.5 49.8 ± 15.6
JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group 24.0 ± 7.6 33.4 ± 10.7 45.2 ± 6.1 51.3 ± 20.7
Drop pill group 24.9 of the present invention ± 3.0 34.7 ± 13.5 46.9 ± 17.2 52.5 ± 18.2
The result shows that drop pill of the present invention has certain analgesic activity, and effect is better than JIAWEI HUOXIANG ZHENGQI WAN and JIAWEI HUOXIANG ZHENGQI RUANJIAONANG.
2. to the influence of gastric emptying
Get 30 of body weight 18～22g mices, be divided into 3 groups at random: JIAWEI HUOXIANG ZHENGQI WAN group, JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group and drop pill group of the present invention.Difference gastric infusion JIAWEI HUOXIANG ZHENGQI WAN, JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group and drop pill of the present invention, dosage is 7g/kg, and every day 1 time, continuous 5 days, fasting 12h before the experiment can't help water.Behind last administration 45min, irritate the phenol red reagent of stomach (gelatin 3g, water 50ml, 0.05% phenol red 20ml) 0.6ml for every.Get stomach behind the 15min and shred, place the NaOH solution of 20ml 0.1mol/L, leave standstill 60min after, get its supernatant 5ml, add 20% trichloroacetic acid 0.5ml, it is centrifugal to shake up the back, gets supernatant 2ml, adds the NaOH solution of 3ml0.5mol/L, measures absorbance.
Influence to gastric emptying
Group dosage (g/kg) absorbance
JIAWEI HUOXIANG ZHENGQI WAN group 7 0.1142 ± 0.0314
JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group 7 0.1201 ± 0.0415
Drop pill group 7 0.1103 ± 0.0241 of the present invention
The result shows that drop pill of the present invention can obviously suppress the mice gastric emptying.In conjunction with above research, show drop pill of the present invention its function of scalable when gastrointestinal function is hyperfunction, reach the effect of spasmolysis and analgesia, can be in order to the treatment energy-stagnation stomachache.
(2) to the therapeutical effect of hepatitis B
Liver Fibrosis Model is duplicated: select 30 of SD rat for use, male and female half and half, every about 130～160g of body weight.Modeling is respectively organized in the 1st day peeling of experiment and is injected 40%CCl down
40.5ml/100g body weight, later per 4 days subcutaneous injection 40%CCl
4, olive oil 0.3ml/100g body weight, continuous 8 weeks.Each group is all fed with normal diet, freely drinks water.
The experiment grouping: 30 rats are divided into 3 groups at random, JIAWEI HUOXIANG ZHENGQI WAN group, JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group and drop pill group of the present invention, 10 every group.Difference gastric infusion JIAWEI HUOXIANG ZHENGQI WAN, JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group and drop pill of the present invention, dosage is 7g/kg, and every day 1 time, each organizes rat from modeling beginning in the 2nd day administration, finishes up to experiment.The 8th week was put to death rat, got blood, detected hyaluronic acid (HA), laminin (LN) and PC-II.
Each organizes rat blood serum HA, LN, PC-II content relatively
The group Mus is counted HA LN PC-II
JIAWEI HUOXIANG ZHENGQI WAN group 10 147.54 ± 56.12 105.74 ± 50.48 98.57 ± 34.72
JIAWEI HUOXIANG ZHENGQI RUANJIAONANG group 10 143.43 ± 53.38 98.93 ± 47.41 92.27 ± 30.57
Drop pill group 10 145.38 of the present invention ± 60.58 102.67 ± 45.45 96.49 ± 29.50
The detection index of hepatic fibrosis is more, and joint-detection HA, LN, PC-II can reflect the dynamic change of hepatic fibrosis, and hepatic fibrosis is the pathological common grounds of various chronic hepatopathys.The result shows that drop pill of the present invention can improve chronic viral hepatitis B patient symptom, and effect and JIAWEI HUOXIANG ZHENGQI WAN and JIAWEI HUOXIANG ZHENGQI RUANJIAONANG do not have significant difference.
Experimental example 2 bioavailability relatively
The SD rat, body weight 250～280g, male and female half and half,, fasting overnight (can't help water), next day gastric infusion, dosage is 4.0g/kg.Before administration and heart blood sampling after the administration, each blood sample point is with 6 rats.Blood sample is put the anticoagulant heparin pipe, the centrifugal 5min of 3000r/min, and separated plasma is put-30 ° and is saved to analysis.
Rat plasma glycyrrhizic acid concentration change
Time/h slurry glycyrrhizic acid concentration/(ug ° of L
-1)
Drop pill JIAWEI HUOXIANG ZHENGQI RUANJIAONANG of the present invention
0 - -
0.25 1.80±0.20 0.52±0.12
0.5 3.14±1.03 0.86±0.30
1.0 2.24±0.61 1.35±0.56
2.0 1.67±0.45 1.60±0.15
3.0 1.39±1.22 0.83±0.42
6.0 1.14±0.67 0.54±0.23
8.0 0.64±2.24 0.35±0.15
10.0 0.49±0.14 0.26±0.03
The result shows, the solid dispersion state of drop pill of the present invention improves the stripping of medicine and absorbs, and bioavailability is greater than soft capsule.
Experimental example 3 craft screenings
1. the proportioning of medicine and substrate
Medicine and substrate (Macrogol 4000) proportioning
Medicine and substrate composition merge the situation denseness and drip the system situation
1: 1 difficult thick difficulty
1: 2 easy thick difficulty
1: 3 easily moderate easy
1: 4 easy moderate difficulty
1: 5 easily rare easy
2. the coolant and the type of cooling are selected
The coolant and the type of cooling are selected: with methyl-silicone oil, liquid paraffin is coolant, and medicine and substrate were dripped system in 1: 4 behind the ratio mixing.Drip the system condition: system is dripped in (80 ± 2) ℃ insulation, and the drip internal diameter is 4.0mm, external diameter 6.0mm.Coolant temperature adopts gradient or non-gradient mode, and the gradient chilling temperature is distributed as: 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃ (3 temperature-averagings are cut apart the length of cooling column), non-gradient is cooled to 0 ℃～10 ℃.Dripping speed is 20～30/min.Evaluation index: the roundness of drop pill (the minor axis of drop pill/major diameter＞0.8) qualification rate.
Group coolant cools mode cooling column height/cm roundness qualification rate/%
1 methyl-silicone oil gradient 140 91.6 90.2
The non-gradient 180 80.2 81.3 of 2 methyl-silicone oils
3 liquid paraffin gradients 180 73.5 76.8
The non-gradient 140 75.7 72.1 of 4 liquid paraffin
3. drip distance, drip selection fast, temperature
Drip distance, drip selection fast, temperature: the interior external diameter of drip is fixed as 4.0,6.0mm.Evaluation index: the heavy qualification rate of ball is by mass discrepancy requirement of Pharmacopoeia of the People's Republic of China version in 2000: meet ± 7.5% within.
Group temperature/℃ drip a distance/cm drips the ball weight qualification rate/% volatile oil mg/g of speed/(dmin-1)
1 90 3 10～20 78.1 10.3
2 90 4 20～30 86.9 12.6
3 90 6 30～50 83.0 10.1
4 80 3 20～30 97.4 15.6
5 80 4 30～50 95.1 17.2
6 80 6 10～20 94.5 18.5
7 70 3 30～50 91.6 22.5
8 70 4 10～20 93.4 23.4
9 70 6 20～30 96.3 24.0
The too high then effective ingredient of melt temperature is easy to scatter and disappear when dripping system, if a system temperature is low excessively, difficulty is compared in molding again; And drip apart from being the main cause that causes the roundness difference, dripping apart from too small, dropping liquid has little time to shrink, and the ball type is rounding not; Drip apart from excessive, drop becomes flat or is fallen to loose because of action of gravity to produce piller easily; So the optimum condition of preparation drop pill of the present invention is: with the Macrogol 4000 is substrate, according to medicine: the part by weight of substrate=1: 3 adds Macrogol 4000, mixing, the employing internal diameter is that 4.0mm, external diameter are the dropper of 6.0mm, dripping system temperature 70 ℃, droplet speed is that 20～30d/min, a distance are 6cm, splashing in the long cooling column of 140cm, is liquid coolant again with the methyl-silicone oil, and adopt the gradient cooling: the Temperature Distribution of gradient liquid coolant is 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃.
The specific embodiment:
Embodiments of the invention 1: take by weighing: Herba Pogostemonis 326.8g, Folium Perillae 108.9g, Radix Angelicae Dahuricae 108.9g, Rhizoma Atractylodis Macrocephalae (parched) 217.9g, Pericarpium Citri Reticulatae 217.9g, Rhizoma Pinelliae Preparata 217.9g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 217.9g, Poria 108.9g, Radix Platycodonis 217.9g, Radix Glycyrrhizae 217.9g, Pericarpium Arecae 108.9g
Get Cortex Magnoliae Officinalis with 60% ethanol extraction three times, each 1 hour, filter, merging filtrate reclaims ethanol, and being concentrated into relative density is the clear paste I of 1.15 (80 ℃); Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Dahuricae vapor distillation extract volatile oil, and the aqueous solution after the distillation filters, and device is collected in addition; The medicinal residues and the Rhizoma Pinelliae, Poria, Radix Platycodonis, Radix Glycyrrhizae, Pericarpium Arecae, Rhizoma Zingiberis Recens 32.7g and Fructus Jujubae 54.5g decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, merge with above-mentioned aqueous solution, filter, it is 1.12 clear paste that filtrate is concentrated into relative density, centrifugal, supernatant concentration to relative density is the clear paste II of 1.15 (80 ℃); Merge clear paste I and II, be concentrated into the thick paste that relative density is 1.30-1.35, drying under reduced pressure, being ground into fine powder, getting drug extract, is substrate with the Macrogol 4000, according to medicine: the part by weight of substrate=1: 3 adds Macrogol 4000, mixing, the employing internal diameter is 4.0mm, external diameter is the dropper of 6.0mm, drips 70 ℃ of system temperature, dripping speed is 20～30d/min, dripping distance is 6cm, splash in the long cooling column of 140cm, be liquid coolant again with the methyl-silicone oil, adopt the gradient cooling: the Temperature Distribution of gradient liquid coolant is 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃, pill, promptly get drop pill, instructions of taking: oral, every day 3 times, each 10.
Embodiments of the invention 2: take by weighing: Herba Pogostemonis 326.8g, Folium Perillae 108.9g, Radix Angelicae Dahuricae 108.9g, Rhizoma Atractylodis Macrocephalae (parched) 217.9g, Pericarpium Citri Reticulatae 217.9g, Rhizoma Pinelliae Preparata 217.9g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 217.9g, Poria 108.9g, Radix Platycodonis 217.9g, Radix Glycyrrhizae 217.9g, Pericarpium Arecae 108.9g
Get Cortex Magnoliae Officinalis with 60% ethanol extraction three times, each 1 hour, filter, merging filtrate reclaims ethanol, and being concentrated into relative density is the clear paste I of 1.15 (80 ℃); Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Dahuricae vapor distillation extract volatile oil, and the aqueous solution after the distillation filters, and device is collected in addition; The medicinal residues and the Rhizoma Pinelliae, Poria, Radix Platycodonis, Radix Glycyrrhizae, Pericarpium Arecae, Rhizoma Zingiberis Recens 32.7g and Fructus Jujubae 54.5g decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, merge with above-mentioned aqueous solution, filter, it is 1.12 clear paste that filtrate is concentrated into relative density, centrifugal, supernatant concentration to relative density is the clear paste II of 1.15 (80 ℃); Merge clear paste I and II, be concentrated into the thick paste that relative density is 1.30-1.35, drying under reduced pressure, be ground into fine powder, get drug extract, with Macrogol 4000: polyethylene glycol 6000=1: 1 mixture is a substrate, according to medicine: the part by weight of substrate=1: 4 adds polyethylene glycol 6000, mixing, and the employing internal diameter is 3.5mm, external diameter is the dropper of 4.5mm, drip 70 ℃ of system temperature, dripping speed is 20～30d/min, dripping distance is 7cm, splashing in the long cooling column of 130cm, is liquid coolant again with the methyl-silicone oil, and adopt the gradient cooling: the Temperature Distribution of gradient liquid coolant is 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃, pill promptly gets drop pill.
Embodiments of the invention 3: take by weighing: Herba Pogostemonis 326.8g, Folium Perillae 108.9g, Radix Angelicae Dahuricae 108.9g, Rhizoma Atractylodis Macrocephalae (parched) 217.9g, Pericarpium Citri Reticulatae 217.9g, Rhizoma Pinelliae Preparata 217.9g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 217.9g, Poria 108.9g, Radix Platycodonis 217.9g, Radix Glycyrrhizae 217.9g, Pericarpium Arecae 108.9g
Get Cortex Magnoliae Officinalis with 60% ethanol extraction three times, each 1 hour, filter, merging filtrate reclaims ethanol, and being concentrated into relative density is the clear paste I of 1.15 (80 ℃); Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Dahuricae vapor distillation extract volatile oil, and the aqueous solution after the distillation filters, and device is collected in addition; The medicinal residues and the Rhizoma Pinelliae, Poria, Radix Platycodonis, Radix Glycyrrhizae, Pericarpium Arecae, Rhizoma Zingiberis Recens 32.7g and Fructus Jujubae 54.5g decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, merge with above-mentioned aqueous solution, filter, it is 1.12 clear paste that filtrate is concentrated into relative density, centrifugal, supernatant concentration to relative density is the clear paste II of 1.15 (80 ℃); Merge clear paste I and II, be concentrated into the thick paste that relative density is 1.30-1.35, drying under reduced pressure, be ground into fine powder, get drug extract, with the Macrogol 4000 is substrate, according to medicine: the part by weight of substrate=1: 5 adds polyethylene glycol 6000, mixing, and the employing internal diameter is 3.0mm, external diameter is the dropper of 5.0mm, drip 70 ℃ of system temperature, dripping speed is 25～35d/min, dripping distance is 5cm, splashing in the long cooling column of 120cm, is liquid coolant again with the methyl-silicone oil, and adopt the gradient cooling: the Temperature Distribution of gradient liquid coolant is 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃, pill promptly gets drop pill.
Claims (4)
1, a kind of health restoring agastache dripping pill preparation is characterized in that: calculate according to weight: it is prepared from by the extract of Herba Pogostemonis 326.8g, Folium Perillae 108.9g, Radix Angelicae Dahuricae 108.9g, Rhizoma Atractylodis Macrocephalae (parched) 217.9g, Pericarpium Citri Reticulatae 217.9g, Rhizoma Pinelliae Preparata 217.9g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 217.9g, Poria 108.9g, Radix Platycodonis 217.9g, Radix Glycyrrhizae 217.9g and Pericarpium Arecae 108.9g or its corresponding weight.
2, the preparation method of health restoring agastache dripping pill preparation as claimed in claim 1 is characterized in that: get Cortex Magnoliae Officinalis with 60% ethanol extraction three times, each 1 hour, filter, merging filtrate reclaims ethanol, and being concentrated into that relative density surveys in the time of 80 ℃ is 1.15 clear paste I; Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Dahuricae vapor distillation extract volatile oil, and the aqueous solution after the distillation filters, and device is collected in addition; The medicinal residues and the Rhizoma Pinelliae, Poria, Radix Platycodonis, Radix Glycyrrhizae, Pericarpium Arecae, Rhizoma Zingiberis Recens 32.7g and Fructus Jujubae 54.5g decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, merge with above-mentioned aqueous solution, filter, it is 1.12 clear paste that filtrate is concentrated into relative density, centrifugal, it is 1.15 clear paste II that supernatant concentration to relative density is surveyed 80 ℃ the time; Merge clear paste I and II, be concentrated into the thick paste that relative density is 1.30-1.35, drying under reduced pressure is ground into fine powder, gets drug extract, the refabrication drop pill.
3, according to the preparation method of the described health restoring agastache dripping pill preparation of claim 2, it is characterized in that: the thing extract of getting it filled, join in the molten matrix, reuse dropping preparation method pill is condensed in the coolant and removes coolant behind the ball, dry and drop pill.
4, preparation method according to claim 2 or 3 described health restoring agastache dripping pill preparations, it is characterized in that: the thing extract of getting it filled, with the Macrogol 4000 is substrate, according to medicine: the part by weight of substrate=1: 3 adds Macrogol 4000, mixing, the employing internal diameter is 4.0mm, external diameter is the dropper of 6.0mm, drip 70 ℃ of system temperature, dripping speed is 20～30d/min, dripping distance is 6cm, splash in the long cooling column of 140cm, be liquid coolant again with the methyl-silicone oil, the cooling of employing gradient: the Temperature Distribution of gradient liquid coolant is 40 ℃～50 ℃, 10 ℃～30 ℃, 0 ℃～4 ℃, pill, promptly.
Priority Applications (2)
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| CN 200410040997 CN1634530A (en) | 2004-11-04 | 2004-11-04 | Modified Huoxiang Zhengqi drop pill and its preparation method |
| CNB2005102006709A CN100361693C (en) | 2004-11-04 | 2005-11-03 | Health restoring agastache dripping pill preparation and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536692A (en) * | 2013-11-08 | 2014-01-29 | 刘艳菊 | Traditional Chinese medicinal composition for treating gastroenteritis |
| CN105300907A (en) * | 2015-11-11 | 2016-02-03 | 漳州片仔癀药业股份有限公司 | Method for detecting intermediate products for pharmaceutical preparation having effects of relieving superficies, dissipating dampness, regulating qi and harmonizing the center |
-
2004
- 2004-11-04 CN CN 200410040997 patent/CN1634530A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536692A (en) * | 2013-11-08 | 2014-01-29 | 刘艳菊 | Traditional Chinese medicinal composition for treating gastroenteritis |
| CN105300907A (en) * | 2015-11-11 | 2016-02-03 | 漳州片仔癀药业股份有限公司 | Method for detecting intermediate products for pharmaceutical preparation having effects of relieving superficies, dissipating dampness, regulating qi and harmonizing the center |
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