CN1634423A - Externally used Chinese traditional medicine preparation for treating acne and preparation method thereof - Google Patents
Externally used Chinese traditional medicine preparation for treating acne and preparation method thereof Download PDFInfo
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- CN1634423A CN1634423A CN 200410087541 CN200410087541A CN1634423A CN 1634423 A CN1634423 A CN 1634423A CN 200410087541 CN200410087541 CN 200410087541 CN 200410087541 A CN200410087541 A CN 200410087541A CN 1634423 A CN1634423 A CN 1634423A
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Abstract
The invention discloses an externally used Chinese traditional medicine ointment for treating acne, which comprises extract of 1 part of honeysuckle flower, 1 part of kudongpi, 1 part of ledebouriella root, 3 parts of root of red rooted saliva, 3 parts of baikal skullcap root and 4 parts of Chinese dittany bark, mixed liquid of 4 parts of flavescent sophora root, 2.4 parts of Arctium lappa, 1 part of houttuynia cordata and mixed liquid of the extract B with 500-600 parts of deionized water. The invention also discloses the process for the preparation.
Description
Technical field: the present invention relates to a kind of Chinese medicine and preparation method thereof
Background technology: acne (being commonly called as acne), its medicine of treatment is a lot of at present, as method home-made " KONENTRAT femLOVELY SKIN ", " the quick-acting lotion for pimples " that the Foshan produces, they all contain ethanol, skin is had than strong and stimulating, if skin has breakage, pain is arranged after embrocating, and use 15 days effects also not obvious, the someone invents nonalcoholic Chinese medicine preparation for this reason, as disclosed a kind of " Chinese medicine preparation and the preparation method of treatment acne " (application number 03139222.9) on April 28th, 2004 Gazette of Patent for Invention.The composition of said preparation has Calomelas, Hydrargyri Oxydum Rubrum, Semen Ricini, Semen Hydnocarpi and Oleum sesami, almond oil or vaseline.Its weak point is the pathogeny that runs counter to acne.Acne is the commonly encountered diseases of youth of both sexes, main cause is adolescence endocrine generation great change, sebum secretion is vigorous, the follicular epithelium hypertrophy is stopped up the pilosebaceous unit mouth of pipe, causes the sebum alluvial to form follicular orifice keratinization and thromboembolism, and outgrowth sebum can not in time be discharged, thereby generation acne, and containing a large amount of oils and fatss in the composition of above-mentioned patent application, this not only influences the curative effect of other medicine, and makes the people have greasy feeling uncomfortable.
Summary of the invention: the object of the present invention is to provide a kind of, water preparation acne Chinese medicine for outer use non-stimulated, evident in efficacy and preparation method thereof to human body skin.The present invention mainly be with two kinds of water solublity Chinese medicine extract (be called for short A component and B component) with obtain product after various additives and water mix.
(1) Chinese medicine extract
One, A component
1, the raw material of A component is as follows:
1. Flos Lonicerae, it mainly contains Saponin and tannin, and its effect in product of the present invention is analgesic, evacuation of pus, sterilization.
2. cortex meliae, it mainly contains a bitter element, and its effect in product of the present invention is sterilization, go parasite.
3. Radix Saposhnikoviae, it mainly contains quintessence oil, and its effect in product of the present invention is a wind dispelling, detoxifcation.
4. Radix Salviae Miltiorrhizae, it mainly contains the Radix Salviae Miltiorrhizae glycosides, and its effect in product of the present invention is to invigorate blood circulation, change silt.
5. Radix Scutellariae, it mainly contains baicalin, and its effect in product of the present invention is refrigerant, detoxifcation.
2, the preparation method of A component
1. prepare burden
Get above-mentioned five kinds of raw materials, their parts by weight are respectively: 1 part of Flos Lonicerae, 1 part of cortex meliae, 1 part of Radix Saposhnikoviae, 3 parts of Radix Salviae Miltiorrhizaes, 3 parts of Radix Scutellariaes.
2. decoct and extract
The decocting that adds 8-10 times of weight of raw material weight sum boiled 1.5 hours, repeated 2 times, with static the spending the night of liquid that obtains, filtered, and got decocting liquid, was that 90 ℃ of water-baths are concentrated into 1/5 of original volume in temperature, got concentrated solution.
3. ethanol extraction
In above-mentioned concentrate, add isopyknic dehydrated alcohol, after abundant stirring,, get supernatant and be ethanol extract in refrigerator cold-storage 2～3 days.
4. separated
Reclaim ethanol in the 55-149mmHg distilling under reduced pressure, till not having ethanol and distillating, remaining product is Chinese medicine extract A component.
Two, B component
1, the raw material of B component is as follows:
1. Cortex Dictamni, it mainly contains tinea alba alkali, and its effect in product of the present invention is to control wind skin ulcer, scabies.
2. Radix Sophorae Flavescentis, it mainly contains matrine, and its effect in product of the present invention is parasite killing, anthelmintic.
3. Fructus Arctii, it mainly contains Fructus Arctii alkali, and its effect in product of the present invention is wind dispelling, detoxifcation.
4. Herba Houttuyniae, it mainly contains alkaloid, and its effect in product of the present invention is detoxifcation, toxin expelling.
2, the preparation method of B component
1. prepare burden
Get above-mentioned 4 kinds of raw materials, their parts by weight are respectively: 4 parts of Cortex Dictamni, 4 parts of Radix Sophorae Flavescentiss, 2.4 parts of Fructus Arctiis, 1 part of Herba Houttuyniae.
2. percolation extracts
With 0.1% hydrochloric acid and 95% alcoholic acid mixed liquor above-mentioned raw materials being carried out percolation extracts, the weight ratio 5-8 of this mixed liquor and above-mentioned raw materials weight sum: 1, through getting the mixed liquor of ethanol and extract in 24 hours, and in the 55-149mmHg distilling under reduced pressure, reclaim ethanol till do not have ethanol and distillate, remaining product is a percolation extract.
3. acidify
Add the spirit of vinegar acidify in percolation extract, making the liquid pH value is 2～3, places 24 hours after-filtration, gets filtrate.
4. chloroform extraction
Adding in above-mentioned filtrate is the chloroform of its 5 times of volumes, and mix homogeneously is treated to get chloroform solution distillation recovery chloroform after the layering, discards residue.Add ammonia in the oxytropism water layer liquid, the pH value of liquid is transferred to 10.Adding is that the chloroform of its 5 times of volumes extracts alkalization liquid again, treats after the layering chloroform to be reclaimed in the chloroform solution distillation, discards residue, gets alkaline water layer liquid.
5. acidify postprecipitation
In above-mentioned alkaline water layer liquid, add 0.5N hydrochloric acid, its pH value is transferred to 2-4.5, add saturated ammonium tetrathiocyanodiaminochromate again and make its precipitation, filtration, and wash precipitate with water.
6. reduce alkaloid
In above-mentioned precipitate, add acetone, it is dissolved fully, in solution, drip saturated Ag again
2SO
4Solution, till no longer including precipitate, the brium carbonate solution that adds equivalent again decomposes and filters, and the filtrate that obtains is Chinese medicine extract B component.
(2) water and additive
1, the used water of the present invention is deionized water, and its consumption is 500-600 part.
2, the used additive of the present invention mainly contains:
1. solubilizing agent, as tween 80, its addition is 0-30 part;
2. penetrating agent, as the water solublity azone, its addition is 0-30 part;
3. antiseptic, as KF88, germall-2 (Plus) germall K2000, its addition is 0-1 part;
4. anti-pox agent, as azelaic acid derivant K-ADG, its addition is 0-30 part;
5. glycerol, its addition is 0-20 part;
6. propylene glycol, its addition is 0-150 part;
7. vitamin E, its addition is 0-10 part;
8. vitamin C, its addition is 0-5 part;
(3) synthetic
With the deionized water ebuillition of heated, sterilization in 20 minutes adds Chinese medicine extract A, B and stirs when water temperature is cooled to 70 ℃.If there have additive to add to be fashionable, the addition sequence of each component is as follows:
1. when water temperature is cooled to 85 ℃, add solubilizing agent, water solublity penetrating agent, glycerol, propylene glycol, stir;
2. when above-mentioned mixeding liquid temperature is reduced to 80 ℃, add anti-pox agent and natural Vitamin E, stir evenly;
3. when above-mentioned mixeding liquid temperature is reduced to 75 ℃, add fatsoluble vitamin C, stir evenly;
4. when above-mentioned mixeding liquid temperature is reduced to 70 ℃, add Chinese medicine extract A, B, stir evenly;
5. when above-mentioned mixeding liquid temperature is reduced to 60 ℃, add antiseptic, stir evenly;
6. when above-mentioned mixeding liquid temperature is reduced to 46 ℃, filter, get filtrate.
3, packing: filtrate cool to room temperature, the packing that will obtain above, the outward appearance that obtains is that flaxen liquid is product of the present invention.
The present invention has following advantage compared to existing technology:
1, product collection skin of the present invention antiinflammatory, sterilization, nutrition are one, can not only dispel the impression that acne and acne stay, and also have the effect of pore refining, tender white skin care simultaneously.
2, it is just fairly obvious to embrocate 3～7 days effects of product of the present invention, embrocates and just facial illness thoroughly can be effected a radical cure in 1～2 month, no longer recurrence.
3, the soft class material of product of the present invention is to the skin nonirritant; It does not contain any hormone, heavy metal and poisonous chemical constituent yet simultaneously, and is therefore without any side effects, safe in utilization.
4, product of the present invention is water preparation, oil free, embrocates back human body easy absorption, comfortable convenience naturally.
The specific embodiment
Example 1
Extracting honeysuckle 10g, cortex meliae 10g, Radix Saposhnikoviae 10g, Radix Salviae Miltiorrhizae 30g and Radix Scutellariae 30g place heating container, and add the 900g decocting and boiled 1.5 hours, and decoction liquor is poured out, and add the 720g decocting again and boil 1.5 hours.The decoction liquor that obtains for twice is merged static spending the night, after the filtration decocting liquid.This decocting liquid is concentrated into 1/5 of original volume in 90 ℃ of temperature of water-bath, in the concentrated solution of above-mentioned acquisition, adds isopyknic dehydrated alcohol, fully stir the back in static 2 days of 5 ℃ of temperature.Get supernatant and reclaim ethanol, till not having an ethanol distillation, obtain Chinese medicine extract A component in the 55mmHg distilling under reduced pressure.
Get Cortex Dictamni 40g, Radix Sophorae Flavescentis 40g, Fructus Arctii 24g, Herba Houttuyniae 10g place percolation filter, with 570g0.1% hydrochloric acid and 95% alcoholic acid mixed liquor above-mentioned raw materials is carried out diafiltration and extracted 24 hours.The mixed liquor of the ethanol that obtains and extract is reclaimed ethanol in the 55mmHg distilling under reduced pressure, till not having ethanol and distillating.Add spirit of vinegar in percolation extract, making pH value is 2, places 24 hours after-filtration.The chloroform mix homogeneously that adds 5 times of volumes in above-mentioned filtrate is treated to get the chloroform solution distillation after the layering, reclaims chloroform and discards residue.Add ammonia in the oxytropism water layer, the pH value of liquid is transferred to 10, add the chloroform mix homogeneously of 5 times of volumes again, treat to get the chloroform solution distillation after the layering, reclaim chloroform and discard residue.In above-mentioned alkaline water layer liquid, add 0.5N hydrochloric acid, its pH value is transferred to 2, add saturated ammonium tetrathiocyanodiaminochromate again and make its precipitation fully, filter, and wash precipitate with water.Add acetone in above-mentioned precipitate, precipitation is dissolved fully, drip saturated silver sulfate again till no longer include precipitation in solution, the brium carbonate solution that adds equivalent again decomposes and filters, and the filtrate that obtains is Chinese medicine extract B component.
Get 20 minutes postcooling of 500g deionized water ebuillition of heated, when water temperature to 70 ℃, add above-mentioned Chinese medicine extract A, B and stir.Filter when above-mentioned mixeding liquid temperature is reduced to 46 ℃, get filtrate, treat to pack when it is cooled to room temperature, this outward appearance is that flaxen liquid is product of the present invention.
Example 2
Extracting honeysuckle 10g, cortex meliae 10g, Radix Saposhnikoviae 10g, Radix Salviae Miltiorrhizae 30g and Radix Scutellariae 30g place heating container, and add the 900g decocting and boiled 1.5 hours, and decoction liquor is poured out, and add the 720g decocting again and boil 1.5 hours.The decoction liquor that obtains for twice is merged static spending the night, after the filtration decocting liquid.This decocting liquid is concentrated into 1/5 of original volume in 90 ℃ of temperature of water-bath, in the concentrated solution of above-mentioned acquisition, adds isopyknic dehydrated alcohol, fully stir the back in static 3 days of 5 ℃ of temperature.Get supernatant and reclaim ethanol, till not having an ethanol distillation in the 149mmHg distilling under reduced pressure.Obtain Chinese medicine extract A component.
Get Cortex Dictamni 40g, Radix Sophorae Flavescentis 40g, Fructus Arctii 24g, Herba Houttuyniae 10g place percolation filter, with the mixed liquor of 912g 0.1% hydrochloric acid and 95%7 alcohol above-mentioned raw materials is carried out diafiltration and extracted 24 hours.The mixed liquor of the ethanol that obtains and extract is reclaimed ethanol in the 149mmHg distilling under reduced pressure, till not having ethanol and distillating.Add spirit of vinegar in percolation extract, making pH value is 3, places 24 hours after-filtration.The chloroform mix homogeneously that adds 5 times of volumes in above-mentioned filtrate is treated to get the chloroform solution distillation after the layering, reclaims chloroform and discards residue.Add ammonia in the oxytropism water layer, the pH value of liquid is transferred to 10, add the chloroform mix homogeneously of 5 times of volumes again, treat to get the chloroform solution distillation after the layering, reclaim chloroform and discard residue.In above-mentioned alkaline water layer liquid, add 0.5N hydrochloric acid, its pH value is transferred to 4.5, add saturated ammonium tetrathiocyanodiaminochromate again and make its precipitation fully, filter, and wash precipitate with water.Add acetone in above-mentioned precipitate, precipitation is dissolved fully, drip saturated silver sulfate again till no longer include precipitation in solution, the brium carbonate solution that adds equivalent again decomposes and filters, and the filtrate that obtains is Chinese medicine extract B component.
Get 20 minutes postcooling of 600g deionized water ebuillition of heated, when water temperature to 85 ℃, add the solubilizing agent of 30g tween 80,30g water solublity azone penetrating agent, 20g glycerol, 150g propylene glycol and stir.When above-mentioned mixeding liquid temperature was reduced to 80 ℃, the anti-pox agent of adding 30g azelaic acid derivant K-ADG, 10g natural Vitamin E stirred.When above-mentioned mixeding liquid temperature is reduced to 75 ℃, add the 5g fatsoluble vitamin C, stir.When above-mentioned mixeding liquid temperature is reduced to 70 ℃, add Chinese medicine extract A, B, stir.When above-mentioned mixeding liquid temperature is reduced to 60 ℃, add 1g germall K2000 antiseptic, stir.Filter when above-mentioned mixeding liquid temperature is reduced to 46 ℃, get filtrate, treat to pack when it is cooled to room temperature, this outward appearance is that flaxen liquid is product of the present invention.
Claims (4)
1. acne Chinese medicine for outer use, it is characterized in that: said preparation is extract A and 4 parts of Cortex Dictamni, 4 parts of Radix Sophorae Flavescentiss, 2.4 parts of Fructus Arctiis, the extract B of 1 part of Herba Houttuyniae and the mixed liquor of 500-600 part deionized water of 1 portion of Flos Lonicerae, 1 part of cortex meliae, 1 part of Radix Saposhnikoviae, 3 parts of Radix Salviae Miltiorrhizaes, 3 parts of Radix Scutellariaes.
2. acne Chinese medicine for outer use according to claim 1 is characterized in that: also contain the solubilizing agent of 0-30 part, 0-30 part penetrating agent, 0-1 part antiseptic, the anti-pox agent of 0-30 part, 0-2 part glycerol, 0-150 part propylene glycol, 0-10 part vitamin E, 0-5 part vitamin C in the above-mentioned mixed liquor.
3. the preparation method of an acne Chinese medicine for outer use, it is characterized in that: extracting honeysuckle, cortex meliae, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Scutellariae, and to add be that the decocting of 8-10 times of weight of its weight sum boiled 1.5 hours, repeats twice, with static the spending the night of liquid that obtains, filter, get filtrate and be concentrated into 1/5 of original volume, add the equal-volume dehydrated alcohol, stir and be placed on the refrigerator and cooled Tibetan 2-3 days in 90 ℃ of water-baths, get supernatant in the 55-149mmHg distilling under reduced pressure, remaining product is Chinese medicine extract A; Get Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Arctii, Herba Houttuyniae, extracted 24 hours with 0.1% hydrochloric acid and the 95% alcoholic acid mixed liquor diafiltration that are 5-8 times of weight of they weight sums, with the mixed liquor of ethanol and extract in the 55-149mmHg distilling under reduced pressure, adding spirit of vinegar in percolation extract, to make the liquid pH value be 2-3, place filtration in 24 hours, the chloroform that in above-mentioned filtrate, adds 5 times of volumes, be mixed, treat to add ammonia in the oxytropism water layer after the layering, the pH value of liquid is transferred to 10, the chloroform that adds 5 times of volumes again, mixing is treated to get adding 0.5N hydrochloric acid in the alkaline water layer liquid after the layering, its pH value is transferred to 2-4.5, add saturated ammonium tetrathiocyanodiaminochromate again and make its precipitation fully, filter, in precipitate, add acetone, precipitation is dissolved fully, drip saturated silver sulfate solution again till no longer include precipitation in solution, the brium carbonate solution that adds equivalent again decomposes and filters, and the filtrate that obtains is extract B; With 20 minutes postcooling of deionized water ebuillition of heated, when water temperature is reduced to 70 ℃, add above-mentioned Chinese medicine extract A, B and stir, when reducing to 46 ℃, filters mixeding liquid temperature, get filtrate.
4. the preparation method of acne Chinese medicine for outer use according to claim 3, it is characterized in that: when water temperature to 85 ℃, add solubilizing agent, penetrating agent, glycerol, propylene glycol and stir, when mixeding liquid temperature is reduced to 80 ℃, add anti-pox agent, natural Vitamin E stirs, and when mixeding liquid temperature is reduced to 75 ℃, adds vitamin C, stir, when mixeding liquid temperature is reduced to 60 ℃, add antiseptic, stir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 200410087541 CN1634423A (en) | 2004-11-11 | 2004-11-11 | Externally used Chinese traditional medicine preparation for treating acne and preparation method thereof |
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| CN 200410087541 CN1634423A (en) | 2004-11-11 | 2004-11-11 | Externally used Chinese traditional medicine preparation for treating acne and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007246516A (en) * | 2006-02-15 | 2007-09-27 | Megumi Yakkyoku:Kk | Additive for ameliorating skin, and beverage, cosmetic cream, toilet water and lotion using the same |
| CN101869604A (en) * | 2010-06-29 | 2010-10-27 | 浙江大学 | Preparation method and application of cortex meliae effective ingredients |
| CN1969984B (en) * | 2006-12-07 | 2010-12-29 | 刘爱芹 | Externally applied medicament for treating acne and allergy |
| CN102068398A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Allergy-relieving, anti-inflammatory and anti-irritation skin-care composition, preparation and preparation method thereof |
-
2004
- 2004-11-11 CN CN 200410087541 patent/CN1634423A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007246516A (en) * | 2006-02-15 | 2007-09-27 | Megumi Yakkyoku:Kk | Additive for ameliorating skin, and beverage, cosmetic cream, toilet water and lotion using the same |
| CN1969984B (en) * | 2006-12-07 | 2010-12-29 | 刘爱芹 | Externally applied medicament for treating acne and allergy |
| CN101869604A (en) * | 2010-06-29 | 2010-10-27 | 浙江大学 | Preparation method and application of cortex meliae effective ingredients |
| CN102068398A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Allergy-relieving, anti-inflammatory and anti-irritation skin-care composition, preparation and preparation method thereof |
| CN102068398B (en) * | 2010-11-26 | 2013-08-21 | 新时代健康产业（集团）有限公司 | Allergy-relieving, anti-inflammatory and anti-irritation skin-care composition, preparation and preparation method thereof |
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