CN1634362A - Chinese patent medicine for preventing and treating postpartum cow constitutional weakness and retained afterbirth - Google Patents
Chinese patent medicine for preventing and treating postpartum cow constitutional weakness and retained afterbirth Download PDFInfo
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Abstract
The invention discloses a Chinese patent medicine for preventing and treating postpartum cow constitutional weakness and retained afterbirth, which consists of angelica, ligusticum wallichii, red peony root, prepared rhizome of rehmannia, peach kernel, safflower, rhubarb, rhizoma sparganii, rhizoma zedoariae, astragalus, codonopsis pilosula, rhizoma cimicifugae, liquorice, fructus aurantii, scutellaria baicalensis, fresh ginger and motherwort. The veterinary drug is prepared according to etiology and pathology of postpartum deficiency, postpartum stasis and uterine atony of the dairy cow, and after the dairy cow takes the prescription, the uterine smooth muscle can be effectively promoted to shrink, the placenta can be smoothly discharged out of the body, and the veterinary drug has the excellent effects of easing pain, stopping bleeding, diminishing inflammation, smoothly supplementing qi and blood and being beneficial to the quick and early recovery of the organism.
Description
Technical field
The invention belongs to tcm field, relate to a kind of veterinary drug, particularly a kind of Chinese patent medicine of preventing and being used for the treatment of postpartum cow constitutional debility and retained afterbirth that gives.
Technical background
At present, postpartum cow constitutional debility and placenta retention or lochiorrhea are a kind of common frdquently encountered diseases.Sickness rate at some cattle farm placenta retention reaches 25-40%, and is infertile if malpractice very easily causes chronic endometritis to cause, diseases such as also easy secondary mastitis, four gastrokateixias.Its symptom is uneasy for performance, lassitude, and appetite is ruminated minimizing, the angry duty of haunch, the performance posture of urinating is from the vaginal orifice banded afterbirth that hangs down, discharge kermesinus stench liquid from vagina when exerting duty, sometimes slightly suffer from abdominal pain, body temperature is little high, milch cow hypogalactia in puerperal, mammary swelling is hard, milk ejection is not smooth, and amount is few, the pain of touching.Past is adopted the method for intramuscular injection estrogen or peeling operation to retained afterbirth more, and the former is through clinic trial, and effect is very desirable; The latter is too big because of labor intensive, the specification requirement height, and also big to milch cow injury itself, be difficult for promoting.
Summary of the invention
The object of the invention provides the Chinese patent medicine of a kind of prevention and treatment postpartum cow constitutional debility and retained afterbirth, and this medicine can have the above-mentioned symptom of milch cow and gives effect anti-and treatment.
The objective of the invention is to be achieved through the following technical solutions:
This Chinese patent medicine is made up of the Chinese medicine ingredients of following weight parts: Herba Leonuri 55-65g, Radix Angelicae Sinensis 35-40g, Rhizoma Chuanxiong 20-30g, Radix Rehmanniae Preparata 35-45g, Radix Paeoniae Rubra 25-35g, Radix Et Rhizoma Rhei 20-30g, Radix Scutellariae 25-35g, Rhizoma Curcumae 15-25g, Rhizoma Zingiberis Preparatum 25-35g, Radix Codonopsis 25-35g, Radix Astragali 45-55g, Semen Persicae 25-35g, Flos Carthami 15-25g, Fructus Aurantii 45-55g, rhizoma sparganic 15-25g, Rhizoma Cimicifugae 15-25g, Radix Glycyrrhizae 25-35g.
Its preparation method is, above-mentioned prescription is removed impurity, dried the back and pulverize, cross 80 mesh sieves, sternly seals with the double-layer plastic bag by every bag 400g to get final product.
Chinese patent medicine of the present invention is taken for milch cow and can promote uterine smooth muscle to shrink effectively puerperal, makes afterbirth as advancing to excrete, and analgesia is arranged, hemostasis, antiinflammatory, the flat excellent results that fills blood, is beneficial to the anxious rehabilitation early of body.
The specific embodiment
The pharmacodynamics test of this Chinese patent medicine that provides below in conjunction with the inventor and acute and long term toxicity test and specific embodiment are described in further detail the present invention.
Milch cow is at phenolics, because fetal development need be drawn the sufficient nutrition material from placenta materna, nutrition arrangement faces main being negligent of of some poultrys or the plain body weakness of female animal in addition, all can cause the calver plastid and descend, and more ought just before giving birth have some setbacks, lose blood more for a long time, nature can make cow present resembling of the empty meaning of vim and vigour.
Chinese medicine ingredients Radix Angelicae Sinensis in this prescription, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Rehmanniae Preparata are the special agent that cloudy blood is subjected to disease, yet tangible blood can not be fast living, and invisible gas should suddenly be consolidated, thus must in prescription, add with the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, to receive the effect of qi-supplementing, blood-engendering; Because of the perinatal stage cow has resembling of blood stasis more, so use Herba Leonuri in the prescription, Semen Persicae, Flos Carthami, Radix Et Rhizoma Rhei, rhizoma sparganic, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling carry out hemostasis and pain-relieving again; Add Herba Leonuri, Fructus Aurantii, Rhizoma Cimicifugae, phase 5, both can promote that the retraction of uterine smooth muscle was moving, and can bring into play the duty of the lifting of mechanism of qi again, more with Radix Scutellariae, Rhizoma Zingiberis Preparatum, Radix Glycyrrhizae mediation cold and heat, full side is mended and oiliness, temperature and not dry, cold and do not coagulate, thus reach blood stasis dispelling, blood and do not hinder fresh blood, fill blood and remove deficiency-heat, ascending the clear and descending the turbid, longue meat and the effect of rehabilitation power body.
Below be pharmacodynamics test and the acute and long term toxicity test that the present invention fills a prescription, and the specific embodiment that provides of inventor.
1. pharmacodynamics test
The treatment postpartum cow constitutional debility of producing by above-mentioned preparation and the compound Chinese patent medicine of placenta retention through Xibei Univ. of Agricultural ﹠ Forest Science ﹠ Technology's animal and veterinary institute and animal and veterinary institute of Xibei Univ. of Agricultural ﹠ Forest Science ﹠ Technology from year March in October, 1997 to 2004, accept this type of case 876 examples altogether for medical treatment, cure 822 examples, cure rate reaches more than 90%.Practice shows that this Chinese patent medicine for animals be better than hormonotherapy and artificial therapy significantly, and expense is low, no any untoward reaction after the medication to the good effect of postpartum cow constitutional debility and placenta retention symptom.
| Group | Dosage (g/ days) | Sick cattle number (head) | Cure rate (%) | Remarks |
| Matched group | 0 | ?10 | ?0 | |
| Organize in a small amount | 300 | ?10 | ?80 | Administration time is longer, and total dosage is big |
| Middle amount group | 400 | ?10 | ?91 | The medication phase is short, and total dosage is little |
| A large amount of groups | 500 | ?10 | ?60 |
2. acute and long term toxicity test
Once irritate each 20 of stomach mices with the dose of the tolerant Cmax of animal (3g/ml), 0.8ml, male and female half and half were observed 7 days continuously, did not take place dead.Dosage is the 120g/kg body weight, is equivalent to 179.1 times of clinical consumption.At viewing duration, do not find that animal has obvious poisoning symptom.
3. the long-term toxicity test for animals rat was irritated stomach Chinese patent medicine 5g/kg/d of the present invention, 15g/kg/d (be equivalent to clinical administration dosage 7.4,22.2 times) respectively continuous four months, general activity behind the two dosage group rat medicines, the mental status, hair, feces etc. show no obvious abnormalities.Peripheral hemogram before and after the administration comprises that erythrocyte, leukocyte and classification, hemoglobin, packed cell volume all fluctuate in normal range.Three livers (SGPT, SGOT), kidney (blood urea nitrogen, creatinine) functional parameter be there is no obvious influence.During off-test, the content of total protein, albumin, alkali phosphatase is compared no significant difference with matched group in the animal serum.Electrocardioscopy is all no abnormal.Each main organs macroscopy is not seen morphological changes of various tissue components such as obvious enlargement, hyperemia, necrosis.The weight coefficient of the heart, liver, spleen, lung, kidney, thymus, adrenal gland, uterus, testis is compared with matched group, no significant difference.Histopathologic examination there is no unusual.This medicine of above presentation of results is safer, in institute's amount of reagent scope.
4. the clinical verification of Chinese patent medicine of the present invention
| Symptom | The example number | Curative effect % | Total effective rate % | |||
| Cure | Produce effects | Effectively | Invalid | |||
| Lochia is not all right | 78 | ?75 | ?2 | ?1 | ?0 | ?100 |
| Placenta retention | 66 | ?63 | ?2 | ?1 | ?100 | |
| Stomachache | 19 | ?17 | ?1 | ?1 | ?0 | ?100 |
| Asymmetric uterine | 16 | ?15 | ?1 | ?0 | ?100 | |
| Puerperal endometritis | 42 | ?38 | ?2 | ?2 | ?0 | ?100 |
| Add up to | 221 | ?208 | ?7 | ?6 | ?0 | ?100 |
Illustrate:
1. clinical verification material therefor and method
Medicine: the Chinese patent medicine that uses aforementioned formula and production technology to manufacture.
Observational technique: select homeliness type retained afterbirth by the diagnosis of " veterinary clinic " required standard.Take continuously the placenta retention symptom, wrap (400g) every day for oral administration 1, and continuously 5-7 day, afterbirth can come off voluntarily, and to the prolonged lochia symptom, 2-4 bag for oral administration gets final product.
2. side effect: 822 routine experimenters apparent side effect all do not occur at period in a medicine.
4. specific embodiment:
Embodiment 1:
The best of the Chinese patent medicine for animals of this treatment barrenness of milk cow is formulated as: Herba Leonuri 60g, Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 25g, Radix Rehmanniae Preparata 40g, Radix Paeoniae Rubra 30g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 30g, Rhizoma Curcumae 20g, Rhizoma Zingiberis Preparatum 30g, Radix Codonopsis 30g, Radix Astragali 50g, Semen Persicae 30g, Flos Carthami 20g, Fructus Aurantii 50g, rhizoma sparganic 20g, Rhizoma Cimicifugae 20g, Radix Glycyrrhizae 30g;
Its preparation method is that said medicine is cleaned, and after drying, pulverizes, and crosses 80 mesh sieves, and is standby with the tight envelope of double-layer plastic bag by every bag 400g.
Embodiment 2:
Being formulated as of the Chinese patent medicine for animals of this treatment barrenness of milk cow: Herba Leonuri 55g, Radix Angelicae Sinensis 35g, Rhizoma Chuanxiong 20g, Radix Rehmanniae Preparata 35g, Radix Paeoniae Rubra 25g, Radix Et Rhizoma Rhei 20g, Radix Scutellariae 25g, Rhizoma Curcumae 15-25g, Rhizoma Zingiberis Preparatum 25g, Radix Codonopsis 25g, Radix Astragali 45g, Semen Persicae 25g, Flos Carthami 15g, Fructus Aurantii 45g, rhizoma sparganic 1g, Rhizoma Cimicifugae 15g, Radix Glycyrrhizae 25g.
Preparation method is with embodiment 1.
Embodiment 3:
Being formulated as of the Chinese patent medicine for animals of this treatment barrenness of milk cow: Herba Leonuri 65g, Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 30g, Radix Rehmanniae Preparata 45g, Radix Paeoniae Rubra 35g, Radix Et Rhizoma Rhei 30g, Radix Scutellariae 35g, Rhizoma Curcumae 25g, Rhizoma Zingiberis Preparatum 35g, Radix Codonopsis 35g, Radix Astragali 55g, Semen Persicae 35g, Flos Carthami 25g, Fructus Aurantii 55g, rhizoma sparganic 25g, Rhizoma Cimicifugae 25g, Radix Glycyrrhizae 35g.
If be used for producing in batches, can be by the proportional amplification of above-mentioned prescription.
Medicine of the present invention adapts to the following clinical symptoms of milch cow:
Divide the puerperium to surpass 12 hours afterbirths and do not discharge, lassitude, loss of appetite, body temperature is more than 39 ℃, and haunch is angry frequently blames.Or afterbirth normally comes off, but still the lochia amount is many a few days in puerperal, is dirty red, brown, and is stench, and slight stomachache is arranged.Examination per rectum: cornua uteri is asymmetric, and Uterus wall thickens, pressure fluctuation arranged.
Drug use method of the present invention:
To the placenta retention symptom, wrap (400g) every day for oral administration 1, and continuously 5-7 day, afterbirth can come off voluntarily, and to the prolonged lochia symptom, 2-4 bag for oral administration gets final product.
Treatment case 1:
16 years old Fresian of Fufeng County on August 17 section local Zan raising in 2002 is examined.The main suit: body constitution was relatively poor when this cattle produced, and in 3 days puerperal, afterbirth only exposes outside the vaginal orifice and can not come off.Inappetence is scratched waist and is exerted duty.Take diffusing 5 bags in the tonification clearing heat in the pericardium, afterbirth comes off voluntarily after 2 days, and all recover normal this cattle.
Treatment case 2:
3.5 years old milch cow that Da Zhuan township, Wugong County Huang raises, examine the main suit on November 9th, 2002: in 8 days puerperal, afterbirth normally came off at that time, but nearest 2 days, the dirty lochia cruenta of volume, stench is discharged in the uterus, pastures and ruminates minimizing, and spirit is depressed.Check T39.5 ℃, examine and be the puerperal infection lochiorrhea, divide with loosing with the 3 bag tonification clearing heats in the pericardium 3 days for oral administration, the tetracycline of intravenous injection every day simultaneously 5g, this cattle disease disease recovery from illness.
Claims (2)
1, a kind of Chinese patent medicine that is used to prevent and treat postpartum cow constitutional debility and retained afterbirth is characterized in that this Chinese patent medicine is made up of the Chinese medicine ingredients of following weight parts: Herba Leonuri 55-65g, Radix Angelicae Sinensis 35-45g, Rhizoma Chuanxiong 20-30g, Radix Rehmanniae Preparata 35-45g, Radix Paeoniae Rubra 25-35g, Radix Et Rhizoma Rhei 20-30g, Radix Scutellariae 25-35g, Rhizoma Curcumae 15-25g, Rhizoma Zingiberis Preparatum 25-35g, Radix Codonopsis 25-35g, Radix Astragali 45-55g, Semen Persicae 25-35g, Flos Carthami 15-25g, Fructus Aurantii 45-55g, rhizoma sparganic 15-25g, Rhizoma Cimicifugae 15-25g, Radix Glycyrrhizae 25-35g.
2, the Chinese patent medicine that is used for the treatment of postpartum cow constitutional debility and retained afterbirth as claimed in claim 1 is characterized in that this Chinese patent medicine is made up of the Chinese medicine ingredients of following weight parts: Herba Leonuri 60g, Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 25g, Radix Rehmanniae Preparata 40g, Radix Paeoniae Rubra 30g, Radix Et Rhizoma Rhei 25g, Radix Scutellariae 30g, Rhizoma Curcumae 20g, Rhizoma Zingiberis Preparatum 30g, Radix Codonopsis 30g, Radix Astragali 50g, Semen Persicae 30g, Flos Carthami 20g, Fructus Aurantii 50g, rhizoma sparganic 20g, Rhizoma Cimicifugae 20g, Radix Glycyrrhizae 30g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410073290 CN1253203C (en) | 2004-11-18 | 2004-11-18 | Chinese patent medicine for preventing and treating postpartum cow constitutional weakness and retained afterbirth |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410073290 CN1253203C (en) | 2004-11-18 | 2004-11-18 | Chinese patent medicine for preventing and treating postpartum cow constitutional weakness and retained afterbirth |
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| Publication Number | Publication Date |
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| CN1634362A true CN1634362A (en) | 2005-07-06 |
| CN1253203C CN1253203C (en) | 2006-04-26 |
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| CN (1) | CN1253203C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133307A (en) * | 2011-03-05 | 2011-07-27 | 中国农业科学院兰州畜牧与兽药研究所 | Medicament for promoting involution of uterus of puerperal dairy cows |
| CN101569697B (en) * | 2009-06-12 | 2011-10-26 | 河北科星药业有限公司 | Chinese traditional medicine for treating postpartum retained afterbirth of female animals |
| CN102600330A (en) * | 2012-03-31 | 2012-07-25 | 四川农业大学 | Curettage medicine composition for dairy cattles |
| CN102783564A (en) * | 2012-08-01 | 2012-11-21 | 六安亿牛乳业有限公司 | Application method for Chinese herbal medicine during perinatal period of dairy cow |
| CN103316312A (en) * | 2013-05-04 | 2013-09-25 | 内蒙古瑞普大地生物药业有限责任公司 | Invigorating uterus-clearing mixture and preparation process thereof |
| CN104706805A (en) * | 2015-03-31 | 2015-06-17 | 甘肃省动物疫病预防控制中心 | Traditional Chinese medicine for treating postpartum retained fetal membranes of cows |
| CN104855739A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Feed additive used for cows postpartum and preparation method thereof |
| CN106551091A (en) * | 2015-09-22 | 2017-04-05 | 刘吴阳 | It is a kind of to cure cow stagnation of QI-blood, retention of afterbirth feed addictive |
| CN107929577A (en) * | 2017-11-16 | 2018-04-20 | 贵州集群农业发展有限公司 | A kind of Chinese medicine composition for treating dam puerperal asthenia and preparation method thereof |
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2004
- 2004-11-18 CN CN 200410073290 patent/CN1253203C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569697B (en) * | 2009-06-12 | 2011-10-26 | 河北科星药业有限公司 | Chinese traditional medicine for treating postpartum retained afterbirth of female animals |
| CN102133307A (en) * | 2011-03-05 | 2011-07-27 | 中国农业科学院兰州畜牧与兽药研究所 | Medicament for promoting involution of uterus of puerperal dairy cows |
| CN102600330A (en) * | 2012-03-31 | 2012-07-25 | 四川农业大学 | Curettage medicine composition for dairy cattles |
| CN102600330B (en) * | 2012-03-31 | 2013-12-04 | 四川农业大学 | Curettage medicine composition for dairy cattles |
| CN102783564A (en) * | 2012-08-01 | 2012-11-21 | 六安亿牛乳业有限公司 | Application method for Chinese herbal medicine during perinatal period of dairy cow |
| CN103316312A (en) * | 2013-05-04 | 2013-09-25 | 内蒙古瑞普大地生物药业有限责任公司 | Invigorating uterus-clearing mixture and preparation process thereof |
| CN103316312B (en) * | 2013-05-04 | 2015-12-23 | 内蒙古瑞普大地生物药业有限责任公司 | A kind of tonification clearing heat in the pericardium mixture and preparation technology thereof |
| CN104706805A (en) * | 2015-03-31 | 2015-06-17 | 甘肃省动物疫病预防控制中心 | Traditional Chinese medicine for treating postpartum retained fetal membranes of cows |
| CN104855739A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Feed additive used for cows postpartum and preparation method thereof |
| CN106551091A (en) * | 2015-09-22 | 2017-04-05 | 刘吴阳 | It is a kind of to cure cow stagnation of QI-blood, retention of afterbirth feed addictive |
| CN107929577A (en) * | 2017-11-16 | 2018-04-20 | 贵州集群农业发展有限公司 | A kind of Chinese medicine composition for treating dam puerperal asthenia and preparation method thereof |
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