CN1634357A - External used Chinese traditional medicine lotion for treating gynaecologic inflammation - Google Patents

Abstract

The invention discloses an external used Chinese traditional medicine lotion for treating gynaecologic inflammation, which is prepared from (by weight ratio) bear gall powder 0.20-0.25%, flavescent sophora root 32-35%, cnidium fruit 20-24%, coptis root 16-18%, pseudolarix 10-12%, orpiment 0.5-0.8%, clove leaves 10-12%, black catechu 0.8-1.0%, allume 0.8-1.0%.

Description

A kind of Chinese medicine external-use lotion for the treatment of gynecological inflammation

Technical field

The present invention relates to the gynopathic Chinese patent medicine of a kind of treatment, especially relate to a kind of Chinese medicine external-use lotion for the treatment of gynecological inflammation.

Background technology

Women's damp invasion of lower energizer morbid leukorrhea is commonly encountered disease, frequently-occurring disease.At present, this disease has the trend that sickness rate increases, age of onset shifts to an earlier date, strong, the easily recurrence of this disease transmission, and serious threat women's physical and mental health, at present, and though this sick medicine of treatment is many on the market, unsatisfactory curative effect.

Summary of the invention

The objective of the invention is for overcoming disadvantages of background technology, and provide a kind of easy to use, release is rapid and the Chinese medicine external-use lotion of the treatment gynecological inflammation of quick relief of symptoms.

The object of the present invention is achieved like this: it is the medicament of being processed into by the following raw materials by weight percent medicine:

Fel Ursi powder 0.2%～0.25%, Radix Sophorae Flavescentis 32%～35%, Fructus Cnidii 20%～24%, Rhizoma Coptidis 16%～18%, Cortex Pseudolaricis 10%～12%, Realgar 0.5%～0.8%, Folium Caryophylli 10%～12%, catechu 0.8%～1.0%, Alumen (forging) 0.8%～1.0%.

The Fel Ursi powder dry product that to be the ursidae animal black bear get through gallbladder fodder operative drainage bile has heat clearing away, suppressing the hyperactive liver, the effect that makes eye bright in the above-mentioned prescription; Be used for convulsion with spasms, external treatment conjunctival congestion and swelling pain, laryngopharynx swelling and pain.Fructus Cnidii is a samphire, contains pinene, isovaleric acid borneol acetate, osthole, Columbianetin (+)-Columbianetin., bergapton, osthole, isopimpinellin etc.; Warm in nature, acrid in the mouth, hardship, warming the kidney to invigorate YANG, dampness, dispel the wind, parasite killing; Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.Rhizoma Coptidis is a ranunculaceae plant, contains multiple alkaloid, is mainly berberine, is hydrochlorate and exists, and secondly for coptisine, 13-methyl-.psi.-coptisine. (Coptis Teeta Wall does not have), palmatine, jateorhizine, in addition, still contains magnoline and ferulic acid etc.; Cold in nature, bitter in the mouth, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication is used for damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, the conjunctival congestion acid regurgitation, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.Radix Sophorae Flavescentis is the perennial fallen leaves of pulse family semishrub plants, contain matrine, oxymatrine, sophor-anol, N-Methylcytisine, Anagyrine, baptifoline, dehydrogenation matrine, d-Iosmatrine, kuraridin 2,2',4,4'-Tetrahydroxy-6'-methoxy-3'-(5-methyl-2-isopropenylhex-4-enyl)chalcone, nor-kurarinone, kuraridin 2,2',4,4'-Tetrahydroxy-6'-methoxy-3'-(5-methyl-2-isopropenylhex-4-enyl)chalcone alcohol, Radix Sophorae Flavescentis alcohol, neokurarinol, nor-Radix Sophorae Flavescentis alcohol, isokurarinone, other contains formononetin; Hardship, cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, dispelling wind for relieving itching; Be used for jaundice due to damp-heat, hygropyretic dysentery, damp-heat vaginal discharge are the pudendum pruritus due to damp pathogen, rubella pruritus, skin ulcer, scabies, tinea, leprosy card.Alumen is that Sulfates mineral Alumen is made through the processing refinement, the main aqueous sulfuric acid aluminum potassium that contains, external detoxifcation parasite killing, dampness removing to stop itchin; Hemostasis antidiarrheal for oral administration is dispeled wind-phlegm; External treatment is used for eczema, scabies, discharging ear; For oral administration be used for incessant chronic diarrhea, have blood in stool, metrorrhagia, epilepsy is gone mad; The dried Alumen removing dampness is held back skin ulcer, and hemostasisization is rotten, is used for the eczema eczema, discharging ear, and the pudendal pruritus leukorrhagia, the epistaxis bleeding from the gum, nose is meat most.Cortex Pseudolaricis is dry root bark or the near root bark of pinaceae plant golden larch, the chemical constituent pseudolaric acid that is contained, corter pseudolaricis acetic acid, furan acid, betulic acid and glycoside etc., and suffering, temperature, poisonous, return lung, spleen channel; Have parasite killing, antipruritic, be used for the scabies pruritus.Realgar is a sulfide-based mineral Realgar family Realgar, the main realgar (As that contains ₂S ₂); Suffering, temperature, poisonous, return liver, large intestine channel; Have the detoxifcation parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria is used for the carbuncle furuncle, snake bite and insect sting, abdominal pain due to worm stagnation, infantile convulsion, malaria.Catechu is the peeling branch of leguminous plant catechu, dried dry soft extracts, contains catechin and epicatechin, and nature and flavor hardship, puckery is slightly cold, and returns lung meridian; The removing dampness promoting tissue regeneration and ulcer healing is used for ulcer being unable to heal, eczema, and aphtha is fallen and is pounced on the pain of injury, traumatic hemorrhage.Flos Caryophylli is a sweet-scented osmanthus section plant, heat-clearing and toxic substances removing, and anti-inflammatory anti-itch is used for bacterial infection diseases such as acute bacillary dysentery, enteritis and upper respiratory tract infection, laryngopharynx swelling and pain, acute and chronic tonsillitis's disease.

The present invention compared with prior art has the following advantages: the present invention has removing damp-heat, the effect of killing parasites for relieving itching, cure mainly women's damp heat downward flowing type leukorrhagia, disease sees that pudendal pruritus causalgia, profuse leukorrhea, flavor are smelly, show bubble, bean dregs sample or yellow skin such as pus, yellowish fur, rapid pulse etc., is used for mycotic, infusorian property, the nonspecific vaginitis person that sees the above-mentioned symptom.Have the fast release of dissolving advantage rapidly, reach the purpose of quick relief of symptoms and treatment, be worth in clinical, applying.

The tool present embodiment

Below in conjunction with embodiment in detail the present invention is described in detail:

Embodiment 1

Present embodiment is the medicament of being processed into by the following raw materials by weight percent medicine:

Fel Ursi powder 0.23%, Radix Sophorae Flavescentis 34.3%, Fructus Cnidii 23%, Rhizoma Coptidis 17.2%, Cortex Pseudolaricis 11.4%, Realgar 0.69%, Folium Caryophylli 11.4%, catechu 0.89%, Alumen (forging) 0.89%.

Its preparation method: (1) get said medicine by " one one of Chinese pharmacopoeia version in 2000 and Shaanxi Province's drug standard are concocted, qualified after preparation as follows;

(2) Realgar powder is broken into impalpable powder, mixing, and double-deck polyethylene pack, numbering, to be checked, standby after the assay was approved;

(3) Fel Ursi powder, catechu, Alumen three flavors are ground into fine powder, mixing, and double-deck polyethylene pack, numbering, to be checked, standby after the assay was approved;

(4) Folium Caryophylli, Fructus Cnidii decoct with water secondary, and each 1 hour, collecting decoction filtered, and filtrate is concentrated into the clear paste that relative density is 1.20～1.24 (80 ℃); Cortex Pseudolaricis is given as one thinks fit cataclasm, adds 5 times of amount 75% ethanol, 40 ℃ of warm macerating stain secondaries, and each 48 hours, merge impregnation liquid, filter, filtrate recycling ethanol does not extremely have the alcohol flavor, and is concentrated into the clear paste that relative density is 1.20～1.24 (80 ℃);

(5) get Radix Sophorae Flavescentis, soak slightly, pull out, run through, be cut into 2～4mm sheet, add 4～6 times the amount 75% ethanol, heating and refluxing extraction three times, each 1 hour, merge extractive liquid, left standstill 24 hours, get supernatant, reclaim ethanol and do not distinguish the flavor of, and be concentrated into the clear paste that relative density is 1.20～1.24 (80 ℃) to there being alcohol;

(6) get Rhizoma Coptidis, give as one thinks fit cataclasmly, 0.5% sulfuric acid solution that adds 8 times of amounts decocts twice, and each 2 hours, collecting decoction filtered, and filtrate adds lime cream and transfers PH to 9～10, and standing over night is got supernatant, and being concentrated into relative density is the clear paste of 1.20～1.24 (80 ℃);

(7) above-mentioned fine powder and clear paste are mixed, thin up stirs evenly, and adds suspending agent, stirs evenly, and is distributed into 1000 bottles, promptly.

Embodiment 2

Present embodiment is the medicament of being processed into by the following raw materials by weight percent medicine:

Fel Ursi powder 0.24%, Radix Sophorae Flavescentis 33.22%, Fructus Cnidii 24%, Rhizoma Coptidis 16%, Cortex Pseudolaricis 12%, Realgar 0.70%, Folium Caryophylli 12%, catechu 0.92%, Alumen (forging) 0.92%.

The preparation method of present embodiment is with embodiment 1.

Embodiment 3

Present embodiment is the medicament of being processed into by the following raw materials by weight percent medicine:

Fel Ursi powder 0.21%, Radix Sophorae Flavescentis 35%, Fructus Cnidii 22.5%, Rhizoma Coptidis 18%, Cortex Pseudolaricis 11.01% Realgar 0.59%, Folium Caryophylli 11.01%, catechu 0.84%, Alumen (forging) 0.84%.

The preparation method of present embodiment is with embodiment 1.

Clinical observation case 306 examples of the present invention, colpitis mycotica 86 examples wherein, trichomonal vaginitis 85 examples, senile vaginitis 38 examples, nonspecific vaginitis 98 examples; 20～35 years old 201 age example, 36～50 years old 67 example, 51～65 years old 38 example; The course of disease is less than 3 months person's 193 examples, 3～6 months person's 106 examples, half a year above person's 7 examples.The application of the invention-compound recipe is with infusion liquid to above-mentioned treatment of diseases clearly, its curative effect is: cure rate 75.16%, obvious effective rate 18.95%, effective percentage 4.9%, difference that there are no significant between its curative effect and each sick kind, the course of disease, age and the state of an illness, not finding any side effect and untoward reaction, is the safe and reliable colpitic medicine of treatment.This product external before using shakes up medicinal liquid, and patient gets dorsal position bed hedgehopping buttocks, and the irrigator head is inserted vagina gently, slowly medicinal liquid is clamp-oned intravaginal, once a day, each 1 (50ml), 8 days is a course of treatment, two courses of treatment are used in clinical continuous observation.

The present invention-compound recipe shows through animal acute toxicity experiment with irrigating solution clearly: in 1 day with 1.86g crude drug/kg and 3.73g crude drug/kg (be equivalent to respectively clinical application amount 13.3 times and 26.7 times) dosage, pour into compound recipe for the rat vagina and be with irrigating solution clearly, each administration group administration is not seen after 24 hours and 7 days the local excitation reaction, do not find that all an example is dead, put to death the back gross anatomy, observe each important organ, vaginal congest is not seen in perusal, red and swollen, to heavy dose group rat vagina tissue carry out histopathologic examination and with matched group relatively, also do not see that toxic pathology changes, show that the topical application compound recipe is with irrigating solution nonirritant and toxic reaction clearly.

In sum, the present invention has the good curing effect to gynecological inflammation, and is safe, easy to use, and quick result is worth applying in clinical.

Claims (1)

1, a kind of Chinese medicine external-use lotion for the treatment of gynecological inflammation is characterized in that it is the medicament of being processed into by the following raw materials by weight percent medicine:

Fel Ursi powder 0.2%～0.25%, Radix Sophorae Flavescentis 32%～35%, Fructus Cnidii 20%～24%, Rhizoma Coptidis 16%～18%, Cortex Pseudolaricis 10%～12%, Realgar 0.5%～0.8%, Folium Caryophylli 10%～12%, catechu 0.8%～1.0%, Alumen (forging) 0.8%～1.0%.