CN1633991A - Granular folacin production method and product - Google Patents
Granular folacin production method and product Download PDFInfo
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- CN1633991A CN1633991A CN 200410065633 CN200410065633A CN1633991A CN 1633991 A CN1633991 A CN 1633991A CN 200410065633 CN200410065633 CN 200410065633 CN 200410065633 A CN200410065633 A CN 200410065633A CN 1633991 A CN1633991 A CN 1633991A
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- folic acid
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- folacin
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Abstract
The invention relates to the forming process of folic acid after the synthesizing procedure, which consists of charging deionized water, preparing paste with 28-45% of solid content, loading into screw pump, using a pressure type spray and granulation drier to squeeze the paste out of the screw pump at the air intake temperature of 210-320 deg. C and air-out temperature of 90-150 deg. C, simultaneously carrying out atomizing and granulating, drying and compacting, and finally obtaining 20-120 mesh of granular folic acid product through sieving.
Description
Technical field
The present invention relates to the production method of folic acid, relate in particular to method for processing forming and the product of folic acid after synthesis procedure.
Background technology
Folic acid (C
19H
19N
7O
6) claim vitamin(e) M again, be a kind of anti-anemic drug, also as food additive.The chemical synthesis process of folic acid has multiple, using method early is: make " right-amino benzoyl-the L-glutamate diethyl ester " and " 2-hydroxyl malonaldehyde " reaction, isolate " right-(2; 3-dihydroxy-2-alkene-propylidene amino)-benzoic acid diethylester ", and make this intermediate make folic acid (JACS with " Triaminopyrimidine ketone " reaction again, 70 (1948), 25); Adopted " 2-replaces malonaldehyde " and " right-amino benzoyl-L-glutamic acid " reaction afterwards again, obtain corresponding diimine, and then in the presence of sulphite, be to obtain folic acid (CN1040209C) with " Triaminopyrimidine ketone " reaction under 3～8 conditions in PH; Using commonplace method at present is, make catalyst with sodium acetate, with " triamido hydroxy pyrimidine sulfate ", " to amino sodium glutamate ", " trichloroacetone " and " pyrosulfurous acid " direct reaction, products therefrom obtains purity than higher folic acid through twice purification.
Existing folic acid product is powdery solid, relatively is suitable for making tablet.But, generally popularization along with dosage forms such as capsules, down-stream enterprise wishes that more folic acid supplier provides particle diameter granular folacin product within limits, this has proposed a new technical barrier again for folic acid supplier, need can not only carry out dried to synthetic, the further processing and forming of folic acid afterwards of purifying.
Summary of the invention
Purpose of the present invention is exactly in order to solve the problems of the technologies described above, and a kind of production method of granular folacin is provided, and the granular folacin product that utilizes this method to make.
Purpose of the present invention is achieved through the following technical solutions:
The production method of granular folacin and product are raw material with wet product of the folic acid after the chemosynthesis or dry product, successively according to following steps production:
1. add deionized water, mix, make solid content and be 28%～45% pasty state solidliquid mixture;
2. the screw pump of the pasty state solidliquid mixture being packed into inlet starts screw pump, and the absolute pressure of control screw pump discharging is in 1～2MPa scope;
3. utilizing the press spray granulating and drying machine, is that 210 ℃～320 ℃, leaving air temp are that 90 ℃～150 ℃, absolute pressure are no more than under the 2MPa condition in inlet temperature, with pasty state solidliquid mixture extrusion screw rod pump, carries out mist projection granulating, drying forming synchronously;
4. sieve, collect the product of 20 orders～120 order particle size range, get granular folacin.
3. above-mentioned steps when operation, can utilize the water system dust arrester to remove the fine particle dust that spraying forms.
In the above-mentioned granular folacin production method, employed raw material: the wet product of folic acid are meant the folic acid through chemosynthesis, purification after separating; The folic acid dry product is that the powdery folic acid that obtains afterwards, just the folic acid finished product of prior art are dried, pulverized to the wet product of folic acid.
The invention provides a kind of folic acid and carry out the molding method for processing, obtain particle size range at 20 orders～120 purpose granular folacin products to chemosynthesis, purification after separating.Adopt this technical scheme can play following beneficial effect:
(1) this method is easy, easy to operate, and the operation process is short, and operating condition is not harsh, is suitable in enormous quantities, serialization processing;
(2) the granular folacin product cut size that makes is comparatively even, and good flowing properties is convenient to back road processing factory and is used, and can be directly used in dosage forms such as preparation capsule;
(3) from chemosynthesis to the whole flow process of final use, use technical solution of the present invention and both can save oven dry, the pulverizing process of existing folic acid manufacturer, can save back road processing factory again and dilute operation in advance, play and simplify production procedure, save the production time, advance cleaner production, improve effect such as aggregate production rate, in enterprise, all be highly profitable in society.
The specific embodiment
Embodiment 1
Make catalyst with sodium acetate, " triamido hydroxy pyrimidine sulfate ", " to amino sodium glutamate ", " trichloroacetone " and " pyrosulfurous acid " at 36 ℃～40 ℃ following direct reaction, are obtained once thick folic acid; Use salt acid elution, filtration then, obtain the thick folic acid of secondary; Reuse salt acid elution, and be neutralized to neutrality with alkali liquor filters, the higher wet product of smart folic acid of purity.
With the wet product adding of the smart folic acid that makes deionized water, mix, make solid content and be 28%～45% pasty state solidliquid mixture; The screw pump of then the pasty state solidliquid mixture being packed into inlet starts screw pump, and the absolute pressure of control screw pump discharging is in 1～2MPa scope; Utilizing the press spray granulating and drying machine, is that 210 ℃～320 ℃, leaving air temp are that 90 ℃～150 ℃, absolute pressure are no more than under the 2MPa condition in inlet temperature, with pasty state solidliquid mixture extrusion screw rod pump, carries out mist projection granulating, drying forming synchronously; Sieve, collect the product of 20 orders～120 order particle size range, get granular folacin.It is orange-yellow that product is, and particle diameter is even, good fluidity.
Embodiment 2
With on the market powdery folic acid finished product is raw material, adds deionized water, mixes, and makes solid content and be 28%～45% pasty state solidliquid mixture; The screw pump of then the pasty state solidliquid mixture being packed into inlet starts screw pump, and the absolute pressure of control screw pump discharging is in 1～2MPa scope; Utilizing the press spray granulating and drying machine, is that 210 ℃～320 ℃, leaving air temp are that 90 ℃～150 ℃, absolute pressure are no more than under the 2MPa condition in inlet temperature, with pasty state solidliquid mixture extrusion screw rod pump, carries out mist projection granulating, drying forming synchronously; Sieve, collect the product of 20 orders～120 order particle size range, get granular folacin.It is orange-yellow that product is, and particle diameter is even, good fluidity.
Claims (5)
1. the production method of granular folacin is a raw material with wet product of the folic acid after the chemosynthesis or dry product, successively according to following steps production:
1. add deionized water, mix, make solid content and be 28%～45% pasty state solidliquid mixture;
2. the screw pump of the pasty state solidliquid mixture being packed into, the charging absolute pressure is controlled in 1～2MPa scope;
3. utilizing the press spray granulating and drying machine, is that 210 ℃～320 ℃, leaving air temp are that 90 ℃～150 ℃, absolute pressure are no more than under the 2MPa condition in inlet temperature, with pasty state solidliquid mixture extrusion screw rod pump, carries out mist projection granulating, drying forming synchronously;
4. sieve, collect the product of 20 orders～120 order particle size range, get granular folacin.
2. the production method of granular folacin as claimed in claim 1 is characterized in that: 3. step in the operating process, utilizes the water system dust arrester to remove the fine particle dust that spraying forms.
3. the production method of granular folacin as claimed in claim 1 or 2 is characterized in that: the wet product of described folic acid are the folic acid of chemosynthesis, purification after separating.
4. the production method of granular folacin as claimed in claim 1 or 2 is characterized in that: described folic acid dry product is that the powdery folic acid that obtains is afterwards dried, pulverized to the wet product of folic acid.
5. the particle diameter that obtains by the described method production of above any claim is 20 orders～120 purpose granular folacins.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410065633 CN1633991A (en) | 2004-11-08 | 2004-11-08 | Granular folacin production method and product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410065633 CN1633991A (en) | 2004-11-08 | 2004-11-08 | Granular folacin production method and product |
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| CN1633991A true CN1633991A (en) | 2005-07-06 |
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| CN 200410065633 Pending CN1633991A (en) | 2004-11-08 | 2004-11-08 | Granular folacin production method and product |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070831A (en) * | 2013-02-02 | 2013-05-01 | 常州市新鸿医药化工技术有限公司 | Method for preparing 10-90% folic acid granules |
| CN105440035A (en) * | 2014-09-15 | 2016-03-30 | 北京斯利安制药有限公司 | Low-energy-consumption preparation method for synthesizing high-purity folic acid |
| CN105853376A (en) * | 2016-05-27 | 2016-08-17 | 常州市新鸿医药化工技术有限公司 | Preparation method of folic acid granules |
| CN113180244A (en) * | 2021-05-31 | 2021-07-30 | 临汾市力圣生物科技开发有限公司 | Folic acid drying process |
-
2004
- 2004-11-08 CN CN 200410065633 patent/CN1633991A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070831A (en) * | 2013-02-02 | 2013-05-01 | 常州市新鸿医药化工技术有限公司 | Method for preparing 10-90% folic acid granules |
| CN105440035A (en) * | 2014-09-15 | 2016-03-30 | 北京斯利安制药有限公司 | Low-energy-consumption preparation method for synthesizing high-purity folic acid |
| CN105440035B (en) * | 2014-09-15 | 2018-02-09 | 北京斯利安药业有限公司 | A kind of low energy consumption synthesizes high-purity folic acid preparation method |
| CN105853376A (en) * | 2016-05-27 | 2016-08-17 | 常州市新鸿医药化工技术有限公司 | Preparation method of folic acid granules |
| CN105853376B (en) * | 2016-05-27 | 2018-12-04 | 常州市新鸿医药化工技术有限公司 | A method of preparing folic acid particle |
| CN113180244A (en) * | 2021-05-31 | 2021-07-30 | 临汾市力圣生物科技开发有限公司 | Folic acid drying process |
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