CN103070831A - Method for preparing 10-90% folic acid granules - Google Patents
Method for preparing 10-90% folic acid granules Download PDFInfo
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- CN103070831A CN103070831A CN2013100415058A CN201310041505A CN103070831A CN 103070831 A CN103070831 A CN 103070831A CN 2013100415058 A CN2013100415058 A CN 2013100415058A CN 201310041505 A CN201310041505 A CN 201310041505A CN 103070831 A CN103070831 A CN 103070831A
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- China
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- folic acid
- maltodextrin
- powdery
- granulator
- preparing
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention relates to a method for preparing 10-90% folic acid granules, which comprises the following steps of: a, preparing materials: 8-40kg of maltodextrin and 4-72kg of powdery folic acid; b, preparing the weighed maltodextrin into a solution; c, putting the weighed powdery folic acid into a granulator, starting the granulator, controlling the air inlet temperature to be 60-75 DEG C and the air outlet temperature to be 20-30 DEG C, starting a spray gun and controlling the flow rate of the maltodextrin to be 0.6-0.8kg/ min; d, after the maltodextrin is sprayed out, turning down an air inlet valve, stopping heating when the air outlet temperature reaches 44-50 DEG C, and cooling; and e, when the air outlet temperature is reduced to 20-25 DEG C, sampling and measuring the water content, and stopping discharge when the water content is 5-8.5% to obtain the folic acid granules. According to the method, multiple parameters can be controlled by the granulator, so that the qualified folic acid granules can be prepared.
Description
Technical field
The present invention relates to a kind of 10～90% folic acid preparation method of granules.
Background technology
Existing folic acid is powdery, and static is arranged, and the addition of folic acid is seldom, and the client is difficult for mix homogeneously when adding.After making granule, mobile better, without static, than the easy mix homogeneously of powdery folic acid, but also do not have at present technology folic acid can be made graininess during mixing.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of 10～90% folic acid preparation method of granules.
The technical solution adopted for the present invention to solve the technical problems is: a kind of 10～90% folic acid preparation method of granules comprise the steps: a, prepare material: 8～40 kilograms of maltodextrins, 4～72 kilograms in powdery folic acid; B, the maltodextrin that measures is configured to solution; C, the powdery folic acid that measures is dropped into granulator, 60～75 ℃ of start control inlet temperature, 20～30 ℃ of leaving air temps are opened gun controls maltodextrin flow 0.6～0.8 kg/minute; After d, maltodextrin have sprayed, the air intake valve is turned down, stopped heating cools off when treating that leaving air temp reaches 44～50 ℃; E, when treating that leaving air temp is down to 20～25 ℃, sampling and measuring moisture, moisture are namely shut down discharging between 5～8.5%, make the folic acid granule.
Beneficial effect: the invention solves the defective that exists in the background technology, by granulator control many kinds of parameters, produced qualified folic acid granule.
The specific embodiment
A kind of 10～90% folic acid preparation method of granules comprise the steps: a, prepare material: 8～40 kilograms of maltodextrins, 4～72 kilograms in powdery folic acid; B, the maltodextrin that measures is configured to solution; C, the powdery folic acid that measures is dropped into granulator, 60～75 ℃ of start control inlet temperature, 20～30 ℃ of leaving air temps are opened gun controls maltodextrin flow 0.6～0.8 kg/minute; After d, maltodextrin have sprayed, the air intake valve is turned down, stopped heating cools off when treating that leaving air temp reaches 44～50 ℃; E, when treating that leaving air temp is down to 20～25 ℃, sampling and measuring moisture, moisture are namely shut down discharging between 5～8.5%, make the folic acid granule.
Granulator is a kind of effect of waving with swing roller, the powder stock of humidity can be ground into granule by the iron wire sieve, also can be widely as pulverizing the usefulness that has become piece and become ready-made granule.Granulator is granulated fast, effective, the filter screen of design special hole, and carefully sieving, its friction filter screen bar can be pricked the firm particle of broken sieving, in pharmacy, chemical industry, food industry extensive use.Aspect chemical drugs, be ground into granule as the wet powder that closes, supply compressed tablets after the oven dry, can pulverize at storage period again, and the piece in bulk that condenses or that in chiral process, lump, with dealing with the product such as confection and sugar mixture and Fructus Hordei Germinatus Lac Bovis seu Bubali, industrial as compounds such as pottery, plastics become shaped granule at other in food industry.
Should be appreciated that specific embodiment described above only is used for explaining the present invention, be not intended to limit the present invention.The apparent variation of being extended out by spirit of the present invention or change still are among protection scope of the present invention.
Claims (1)
1. a folic acid preparation method of granules is characterized in that comprising the steps: a, prepares material: 8～40 kilograms of maltodextrins, 4～72 kilograms in powdery folic acid; B, the maltodextrin that measures is configured to solution; C, the powdery folic acid that measures is dropped into granulator, 60～75 ℃ of start control inlet temperature, 20～30 ℃ of leaving air temps are opened gun controls maltodextrin flow 0.6～0.8 kg/minute; After d, maltodextrin have sprayed, the air intake valve is turned down, stopped heating cools off when treating that leaving air temp reaches 44～50 ℃; E, when treating that leaving air temp is down to 20～25 ℃, sampling and measuring moisture, moisture are namely shut down discharging between 5～8.5%, make the folic acid granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100415058A CN103070831A (en) | 2013-02-02 | 2013-02-02 | Method for preparing 10-90% folic acid granules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100415058A CN103070831A (en) | 2013-02-02 | 2013-02-02 | Method for preparing 10-90% folic acid granules |
Publications (1)
| Publication Number | Publication Date |
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| CN103070831A true CN103070831A (en) | 2013-05-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2013100415058A Pending CN103070831A (en) | 2013-02-02 | 2013-02-02 | Method for preparing 10-90% folic acid granules |
Country Status (1)
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| CN (1) | CN103070831A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796498A (en) * | 2014-12-30 | 2016-07-27 | 北京斯利安药业有限公司 | Powder coated folic acid and preparation method thereof |
| CN105853376A (en) * | 2016-05-27 | 2016-08-17 | 常州市新鸿医药化工技术有限公司 | Preparation method of folic acid granules |
| CN113180244A (en) * | 2021-05-31 | 2021-07-30 | 临汾市力圣生物科技开发有限公司 | Folic acid drying process |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186664A (en) * | 1997-11-13 | 1998-07-08 | 北京医科大学实验药厂 | Folic acid supplementing agent for preventing neural tube deformity |
| CN1383829A (en) * | 2001-05-08 | 2002-12-11 | 肖钢 | Compound folic acid prepn for preventing and treating homocysteinemia and relevant diseases |
| CN1633991A (en) * | 2004-11-08 | 2005-07-06 | 常州市牛塘化工厂 | Granular folacin production method and product |
| CN101642425A (en) * | 2008-08-04 | 2010-02-10 | 北京瑞伊人科技发展有限公司 | Folic acid enteric preparation composition and preparation method thereof |
| CN102309464A (en) * | 2011-09-21 | 2012-01-11 | 沈阳格林制药有限公司 | Folic acid tablet and preparation method thereof |
-
2013
- 2013-02-02 CN CN2013100415058A patent/CN103070831A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186664A (en) * | 1997-11-13 | 1998-07-08 | 北京医科大学实验药厂 | Folic acid supplementing agent for preventing neural tube deformity |
| CN1383829A (en) * | 2001-05-08 | 2002-12-11 | 肖钢 | Compound folic acid prepn for preventing and treating homocysteinemia and relevant diseases |
| CN1633991A (en) * | 2004-11-08 | 2005-07-06 | 常州市牛塘化工厂 | Granular folacin production method and product |
| CN101642425A (en) * | 2008-08-04 | 2010-02-10 | 北京瑞伊人科技发展有限公司 | Folic acid enteric preparation composition and preparation method thereof |
| CN102309464A (en) * | 2011-09-21 | 2012-01-11 | 沈阳格林制药有限公司 | Folic acid tablet and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796498A (en) * | 2014-12-30 | 2016-07-27 | 北京斯利安药业有限公司 | Powder coated folic acid and preparation method thereof |
| CN105796498B (en) * | 2014-12-30 | 2019-02-19 | 北京斯利安药业有限公司 | A kind of powder coating folic acid and preparation method thereof |
| CN105853376A (en) * | 2016-05-27 | 2016-08-17 | 常州市新鸿医药化工技术有限公司 | Preparation method of folic acid granules |
| CN105853376B (en) * | 2016-05-27 | 2018-12-04 | 常州市新鸿医药化工技术有限公司 | A method of preparing folic acid particle |
| CN113180244A (en) * | 2021-05-31 | 2021-07-30 | 临汾市力圣生物科技开发有限公司 | Folic acid drying process |
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Application publication date: 20130501 |