CN104621360A - Preparation method of bacitracin zinc premix - Google Patents
Preparation method of bacitracin zinc premix Download PDFInfo
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- CN104621360A CN104621360A CN201510106763.9A CN201510106763A CN104621360A CN 104621360 A CN104621360 A CN 104621360A CN 201510106763 A CN201510106763 A CN 201510106763A CN 104621360 A CN104621360 A CN 104621360A
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Abstract
The invention relates to a preparation method of a bacitracin zinc premix. The preparation method comprises the following steps: a. arranging fermenting liquor into a tank, adding zinc sulfate, adding a flavor agent, a flocculating agent and excipients, stirring for 0.5-2h and standing for 1-3h to obtain a mixed solution; b. filtering the mixed solution obtained in the step a through a diaphragm plate-and-frame filter press, and taking down a filter cake after the filtering is completed; c. granulating the filter cake obtained in the step b, through a rotating mixed granulator to obtain wet granules; d. drying the wet granules obtained in the step c through a vibrating fluidized bed to obtain bacitracin zinc; e. checking; and f. performing finished product packaging. According to the preparation technology of the bacitracin zinc premix, the drying energy consumption is reduced, no odors exists, the product granules are uniform, the mobility is good, the flavor is easily accepted, the operation is convenient and the preparation method is suitable for large-scale production.
Description
Technical field
The present invention is specifically related to a kind of preparation method of Bacitracin Zinc pre-mixing agent.
Background technology
Bacitracin (zinc) is for off-white color is to flaxen powder; Odorless, bitter; Have draw moist; Easily oxidized dose of destruction, in the solution can by various heavy precipitation of salts non-inactivation.Easily molten in water, dissolve in ethanol, insoluble in acetone, chloroform or ether.Bacitracin is unstable in strong acid and strong base, and zinc can improve the stability of bacitracin, and can strengthen the antibacterial activity of bacitracin.Bacitracin Zinc feed addictive does not remain in animal body, do not produce drug resistance, also not easily cross resistance is produced with other drug, be applicable to the multiple poultrys such as pig, ox, chicken, without withdrawal time requirement during use, bacitracin (zinc) " amount can be cured the disease greatly, measured little preventable disease, not have disease can urge long " is widely used antibiotics feed addictive in feed industry.
The more Bacitracin Zinc pre-mixing agent preparation technology that current production adopts, comprise the steps: that zymotic fluid directly and zinc sulfate complexing, after adding appropriate amount of auxiliary materials, mixed liquor is spray-dried obtains finished product.The spray-dired advantage of current use is that technique is simple, but spraying preparation granular size is limited, and bacitracin zymotic fluid cannot realize Separation of Solid and Liquid by conventional filtration means, and in actual production operating process, above technique has following weak point:
1. easily cause dust in spray-drying process, dry peculiar smell is comparatively large, and energy consumption is high;
2. product is powder or granule, and poor fluidity, not easily mixes with feed;
3. product odour is large, is not easily accepted by livestock and poultry.
Summary of the invention
The present invention solves defect existing in above-mentioned prior art, provides a kind of preparation method of Bacitracin Zinc pre-mixing agent, and object is to reduce energy consumption for drying, make the product particle of acquisition evenly, good fluidity.
The present invention is the technical scheme realizing the employing of its object:
A preparation method for Bacitracin Zinc pre-mixing agent, comprises the following steps:
After a, zymotic fluid put tank, in zymotic fluid, add zinc sulfate, add flavouring agent, flocculant and auxiliary material simultaneously, leave standstill 1-3h after stirring 0.5-2h, obtain mixed liquor;
B, the mixed liquor barrier film sheet frame Filter Press obtained by step a, take off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 0.6mm ~ 1.2mm, and controlling rotating speed is that 500 ~ 1000r/min obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent;
E, inspection;
F, finished product packing.
In described step a, the ratio adding zinc sulfate is 8Kg ~ 10Kg/ 1,000,000,000 bacitracin unit.
In described step a, the ratio adding zinc sulfate is 9Kg/ 1,000,000,000 bacitracin unit.
In described step a, in mass volume ratio, the ratio of the flavouring agent added is 0.5-2%.
Flavouring agent described in step a is frankincense type, Fruity type, Radix Glycyrrhizae odor type, one or more of paddy odor type.
In described step a, in mass volume ratio, the ratio of the flocculant added is 1-5%.
Flocculant described in step a is aluminium polychloride, polyacrylamide, shitosan, one or more in cationic starch.
Auxiliary material described in step a is one or more in calcium carbonate, bran powder, wheat bran.
The Stress control that step b septation plate and frame filter press filters is 0.8MPa ~ 1.2MPa, and filtering duration is 4 ~ 8 hours.
The invention has the beneficial effects as follows: Bacitracin Zinc pre-mixing agent preparation technology of the present invention; energy consumption for drying reduces; free from extraneous odour; product particle is even, good fluidity, and smell easily accepts; easy to operate; be suitable for large-scale production, achieved the Separation of Solid and Liquid of bacitracin zymotic fluid by the mode of adding flocculant, thus the granule of arbitrary size can be prepared.
Bacitracin belongs to bacterial fermentation, thalline is tiny, the filter cloth aperture that industry is commonly used is close with thalline size, thalline can block filter opening, filtering velocity is extremely low, and shaping filter cake cannot be pressed into, the present invention by adding flocculant in zymotic fluid, achieve the Separation of Solid and Liquid of zymotic fluid, then cleverly in conjunction with barrier film sheet frame Filter Press, realize effectively filtering fast, wet granular is obtained by rotating pelletizer after filtration completes, this wet granular is without the need to carrying out whole grain process, do not deposit bonding and agglomeration after granulation, can be directly dry on vibrated fluidized bed, obtain the Bacitracin Zinc meeting sieve number.
And this technique because evaporated water is few, overcomes the defect that spraying dry peculiar smell is large in dry run, greatly reducing the appearance of peculiar smell, and can not dust be caused, also can hide a part of peculiar smell by adding flavouring agent, also can cater to livestock and poultry demand, improve livestock and poultry palatability.
Detailed description of the invention
The present invention solves defect existing in prior art, provides a kind of preparation method of Bacitracin Zinc pre-mixing agent, and object is to reduce energy consumption for drying, make the product particle of acquisition evenly, good fluidity.Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1.
After a, zymotic fluid put tank, measure fermentating liquid volume 100L, the total unit of bacitracin 0.08 1,000,000,000, zinc sulfate 0.64Kg is added according to the ratio of 8Kg/ BOU, add 0.5% flavouring agent, 1% flocculant and auxiliary material simultaneously, leave standstill 1h after stirring 0.5h, obtain mixed liquor;
B, the mixed liquor barrier film sheet frame Filter Press that step a is obtained, controlled filter pressure 0.8MPa, filters duration 4 hours, takes off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 0.6mm, and control rotating speed is 500r/min, obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent 19Kg;
E, inspection: the method for inspection according to " People's Republic of China's veterinary drug allusion quotation " is checked, Bacitracin Zinc pre-mixing agent prepared by the present embodiment is all by No. two sieves, record loss on drying dehumidification weight 5.2%, the standard regulation that indices all meets " People's Republic of China's veterinary drug allusion quotation ";
F, finished product packing.
Embodiment 2.
After a, zymotic fluid put tank, measure fermentating liquid volume 120L, the total unit of bacitracin 0.096 1,000,000,000, adds zinc sulfate 0.96Kg according to the ratio of 10Kg/ BOU, adds 2% flavouring agent, 5% flocculant and auxiliary material simultaneously, leave standstill 3h, obtain mixed liquor after stirring 2h;
B, the mixed liquor barrier film sheet frame Filter Press that step a is obtained, controlled filter pressure 1.2MPa, filters duration 8 hours, takes off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 1.2mm, and control rotating speed is 700r/min, obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent 22.8Kg;
E, inspection: the method for inspection according to " People's Republic of China's veterinary drug allusion quotation " is checked, Bacitracin Zinc pre-mixing agent prepared by the present embodiment is all by No. two sieves, record loss on drying dehumidification weight 5.8%, the standard regulation that indices all meets " People's Republic of China's veterinary drug allusion quotation ";
F, finished product packing.
Embodiment 3.
After a, zymotic fluid put tank, measure fermentating liquid volume 150L, the total unit of bacitracin 0.12 1,000,000,000, adds zinc sulfate 0.96Kg according to the ratio of 8Kg/ BOU, adds 1% flavouring agent, 2% flocculant and auxiliary material simultaneously, leave standstill 2h, obtain mixed liquor after stirring 0.5h;
B, the mixed liquor barrier film sheet frame Filter Press that step a is obtained, controlled filter pressure 1MPa, filters duration 6 hours, takes off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 0.8mm, and control rotating speed is 600r/min, obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent 28.5Kg;
E, inspection: the method for inspection according to " People's Republic of China's veterinary drug allusion quotation " is checked, Bacitracin Zinc pre-mixing agent prepared by the present embodiment is all by No. two sieves, record loss on drying dehumidification weight 6.1%, the standard regulation that indices all meets " People's Republic of China's veterinary drug allusion quotation ";
F, finished product packing.
Embodiment 4.
After a, zymotic fluid put tank, measure fermentating liquid volume 180L, the total unit of bacitracin 0.144 1,000,000,000, adds zinc sulfate 1.296Kg according to the ratio of 9Kg/ BOU, adds 1% flavouring agent, 3% flocculant and auxiliary material simultaneously, leave standstill 2h, obtain mixed liquor after stirring 1h;
B, the mixed liquor barrier film sheet frame Filter Press that step a is obtained, controlled filter pressure 1MPa, filters duration 6 hours, takes off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 1.0mm, and control rotating speed is 800r/min, obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent 34.2Kg;
E, inspection: the method for inspection according to " People's Republic of China's veterinary drug allusion quotation " is checked, Bacitracin Zinc pre-mixing agent prepared by the present embodiment is all by No. two sieves, record loss on drying dehumidification weight 6.7%, the standard regulation that indices all meets " People's Republic of China's veterinary drug allusion quotation ";
F, finished product packing.
Embodiment 5.
After a, zymotic fluid put tank, measure fermentating liquid volume 200L, the total unit of bacitracin 0.16 1,000,000,000, zinc sulfate 1.36Kg is added according to the ratio of 8.5Kg/ BOU, add 0.8% flavouring agent, 2% flocculant and auxiliary material simultaneously, leave standstill 1.5h after stirring 1.3h, obtain mixed liquor;
B, the mixed liquor barrier film sheet frame Filter Press that step a is obtained, controlled filter pressure 0.9MPa, filters duration 5 hours, takes off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 0.7mm, and control rotating speed is 1000r/min, obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent 38Kg;
E, inspection: the method for inspection according to " People's Republic of China's veterinary drug allusion quotation " is checked, Bacitracin Zinc pre-mixing agent prepared by the present embodiment is all by No. two sieves, record loss on drying dehumidification weight 6.2%, the standard regulation that indices all meets " People's Republic of China's veterinary drug allusion quotation ";
F, finished product packing.
Embodiment 6.
After a, zymotic fluid put tank, measure fermentating liquid volume 500L, the total unit 0.4 ten hundred million of bacitracin, zinc sulfate 3.8Kg is added according to the ratio of 9.5Kg/ BOU, add 1.5% flavouring agent, 4% flocculant and auxiliary material simultaneously, leave standstill 2.5h after stirring 1.5h, obtain mixed liquor;
B, the mixed liquor barrier film sheet frame Filter Press that step a is obtained, controlled filter pressure 1.1MPa, filters duration 7 hours, takes off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 0.9mm, and control rotating speed is 900r/min, obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent 95Kg;
E, inspection: the method for inspection according to " People's Republic of China's veterinary drug allusion quotation " is checked, Bacitracin Zinc pre-mixing agent prepared by the present embodiment is all by No. two sieves, record loss on drying dehumidification weight 5.4%, the standard regulation that indices all meets " People's Republic of China's veterinary drug allusion quotation ";
F, finished product packing.
Claims (9)
1. a preparation method for Bacitracin Zinc pre-mixing agent, is characterized in that, comprises the following steps:
After a, zymotic fluid put tank, in zymotic fluid, add zinc sulfate, add flavouring agent, flocculant and auxiliary material simultaneously, leave standstill 1-3h after stirring 0.5-2h, obtain mixed liquor;
B, the mixed liquor barrier film sheet frame Filter Press obtained by step a, take off filter cake after having filtered;
C, the filter cake obtained by step b are granulated through the rotation mixer-granulator that mesh size is 0.6mm ~ 1.2mm, and controlling rotating speed is that 500 ~ 1000r/min obtains wet granular;
D, the wet granular that obtained by step c, by vibra fluidized bed drying, obtain Bacitracin Zinc pre-mixing agent;
E, inspection;
F, finished product packing.
2. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 1, is characterized in that, in described step a, the ratio adding zinc sulfate is 8Kg ~ 10Kg/ 1,000,000,000 bacitracin unit.
3. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 2, is characterized in that, in described step a, the ratio adding zinc sulfate is 9Kg/ 1,000,000,000 bacitracin unit.
4. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 1, is characterized in that, in described step a, in mass volume ratio, the ratio of the flavouring agent added is 0.5-2%.
5. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 1, is characterized in that, the flavouring agent described in step a is frankincense type, Fruity type, Radix Glycyrrhizae odor type, one or more of paddy odor type.
6. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 1, is characterized in that, in described step a, in mass volume ratio, the ratio of the flocculant added is 1-5%.
7. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 1, is characterized in that, the flocculant described in step a is aluminium polychloride, polyacrylamide, shitosan, one or more in cationic starch.
8. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 1, is characterized in that, the auxiliary material described in step a is one or more in calcium carbonate, bran powder, wheat bran.
9. the preparation method of a kind of Bacitracin Zinc pre-mixing agent according to claim 1, is characterized in that, the Stress control that step b septation plate and frame filter press filters is 0.8MPa ~ 1.2MPa, and filtering duration is 4 ~ 8 hours.
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| CN201510106763.9A CN104621360A (en) | 2015-03-11 | 2015-03-11 | Preparation method of bacitracin zinc premix |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106359898A (en) * | 2016-08-30 | 2017-02-01 | 齐鲁制药（内蒙古）有限公司 | Preparation method of bacitracin zinc premixing agent |
| CN114632469A (en) * | 2020-12-16 | 2022-06-17 | 安徽进化硅纳米材料科技有限公司 | Silicon dioxide granulation method and device |
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| US2809892A (en) * | 1954-11-01 | 1957-10-15 | Commerical Solvents Corp | Zinc bacitracin feed supplement |
| US3937694A (en) * | 1973-04-16 | 1976-02-10 | Phylaxia Oltoanyag- Es Tapszertermelo Vallalat | Process for the recovery of zinc bacitracin free from zinc hydroxide |
| CN101869188A (en) * | 2010-06-11 | 2010-10-27 | 濮阳泓天威药业有限公司 | Preparation method of nosiheptide premix |
| CN102161693A (en) * | 2010-12-27 | 2011-08-24 | 江苏九阳生物制药有限公司 | Preparation method of zinc bacitracin |
| CN103663160A (en) * | 2013-12-10 | 2014-03-26 | 驻马店华中正大有限公司 | Lifting feeding device for filter cake |
| CN104351483A (en) * | 2014-11-13 | 2015-02-18 | 河北圣雪大成制药有限责任公司 | Preparation method of completely fermented oxytetracycline calcium granules |
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2015
- 2015-03-11 CN CN201510106763.9A patent/CN104621360A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2809892A (en) * | 1954-11-01 | 1957-10-15 | Commerical Solvents Corp | Zinc bacitracin feed supplement |
| US3937694A (en) * | 1973-04-16 | 1976-02-10 | Phylaxia Oltoanyag- Es Tapszertermelo Vallalat | Process for the recovery of zinc bacitracin free from zinc hydroxide |
| CN101869188A (en) * | 2010-06-11 | 2010-10-27 | 濮阳泓天威药业有限公司 | Preparation method of nosiheptide premix |
| CN102161693A (en) * | 2010-12-27 | 2011-08-24 | 江苏九阳生物制药有限公司 | Preparation method of zinc bacitracin |
| CN103663160A (en) * | 2013-12-10 | 2014-03-26 | 驻马店华中正大有限公司 | Lifting feeding device for filter cake |
| CN104351483A (en) * | 2014-11-13 | 2015-02-18 | 河北圣雪大成制药有限责任公司 | Preparation method of completely fermented oxytetracycline calcium granules |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106359898A (en) * | 2016-08-30 | 2017-02-01 | 齐鲁制药（内蒙古）有限公司 | Preparation method of bacitracin zinc premixing agent |
| CN114632469A (en) * | 2020-12-16 | 2022-06-17 | 安徽进化硅纳米材料科技有限公司 | Silicon dioxide granulation method and device |
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