CN1631337A - Apparatus adapted for artificial liver - Google Patents
Apparatus adapted for artificial liver Download PDFInfo
- Publication number
- CN1631337A CN1631337A CN 200410093525 CN200410093525A CN1631337A CN 1631337 A CN1631337 A CN 1631337A CN 200410093525 CN200410093525 CN 200410093525 CN 200410093525 A CN200410093525 A CN 200410093525A CN 1631337 A CN1631337 A CN 1631337A
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- CN
- China
- Prior art keywords
- container
- artificial liver
- peristaltic pump
- pipeline
- transparent cube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention discloses an apparatus adapted for artificial liver, which comprises a holding portion and a control portion, wherein the holding portion is a transparent container made of heat-insulating material equipped with peristaltic pump, a clip holder and conduit support bracket, the control component comprises an electric heater, a heating arrangement, a temperature control system and a control display screen.
Description
Technical field
The invention belongs to biomedical sector, relate to the biomedical a kind of equipment that uses of going up, specifically is a kind of device of the bioreactor that is applicable to, especially artificial liver.
Background technology
Artificial liver support system is complete armarium, Therapeutic Method and the technical specification of a cover.It can temporarily substitute liver partial synthesis, detoxifcation and metabolic function, solved effectively that the patient reduces because of hyperbilirubinemia, endotoxemia, noxious substance savings, disorder of amino acid catabolism, albumin, thrombin due to a large amount of downright bad, the liver failures of hepatocyte and problem such as viremia, reach and improve environment in the patient, reduce virus quantity, block the purpose that toxin increases the weight of the further downright bad vicious cycle of hepatocyte and corrects hepatic coma, for liver cell regeneration creates conditions, gain time, make patient spend dangerous liver failure difficulty and survived.Artificial liver support system environment division wherein is made up of abiotic type artificial liver device and Biotype artificial liver device.More sophisticated in the world bioartificial liver devices has the MELS of Charice Vircbow company, the BLSS of Excorp Medical company etc., and they all have equipment volume bigger, and control complexity and cost are than problems such as height.And the domestic relevant report of still not having maturing appts.
The object of the present invention is to provide a kind of device that is applicable to the Biotype artificial liver, this device simple in structure controlled easyly, and volume is small and light, and cost is lower and practical.
Summary of the invention
The device that is applicable to artificial liver of the present invention, comprise and support part and control section, support sector divides and comprises: a transparent cube container (1), container upper end has 2～4 pipeline holes (8) that communicate with the external world, a peristaltic pump (3) is arranged at the bottom in the container, pipe passage is arranged in the peristaltic pump, the pipeline of bioreactor is come in and gone out from peristaltic pump, 1～2 folder holder (4) that is used to install with the fixed biologically reactor is arranged at the top in the container, and 1～2 support (6,7) that is used to settle bioreactor is arranged around the container inner bottom part peristaltic pump; Control section comprises: a casing (11) that tightly is harmonious with above-mentioned transparent cube container, the face lower end that is harmonious has opening (12) to communicate, be used for leading to and the circulation of steam of control circuit, electric heater (9), electric fan (13) are housed in the casing, heating apparatus and temperature control system (5) are installed in the below of transparent cube container, and boxboard is provided with control display screen (2).The above supports that the transparent cube container of part is to make with insulation material.
Description of drawings
Fig. 1 is the overall structure sketch map that is applicable to the device of artificial liver;
Fig. 2 is the control system logic diagram that is applicable to the device of artificial liver.
The specific embodiment
For further describing design of the present invention, provide following examples.
As shown in Figure 1:
This example is applicable to that the device outside of artificial liver makes a transparent cube container (1) with lucite, container dimensional is wide by 46 * dark 18 * high 38cm, be used for holding biological perfusion parts such as bioreactor, hepatocyte bag, pipeline, the end of container, be placed on the sole of device, fixes by the magnetic stripe sorption.
Internal structure: a heating apparatus and temperature control system (5) are installed in the lower right corner in the container, enough average being distributed in the whole transparent cool-bag of heat energy that heater is produced, and can be by temperature control system with the heating-up temperature basic controlling at certain a bit on (as 37 degree).(11) be the casing that tightly is harmonious with transparent cube container (1), make average being distributed in the entire container of heat of generation in the casing (11) by an electric heater (9) and electric fan (13), by the temperature control part branch make temperature rise to 37 the degree and be controlled at about this temperature, when the rising of heating apparatus temperature is spent above 38, cut off the warmer power supply automatically and stop heating and warning.A peristaltic pump (3) is arranged in the container, and maximum (top) speed is 100rpm, can regulate by the pump speed on the display screen on the panel (2) and control rotating speed.
The door of thermostatic container is in the front, and the inside is except that heating apparatus and temperature control system, and inside the bottom has two supports (6,7) to place bioreactor and pipeline usefulness thereof, and the container internal upper part has a folder holder (4) to place the hepatocyte bag to use; On and off switch, temperature demonstration, extracting power supply cord are arranged on casing (11) panel, and the pipeline hole (8) by door passes in and out container to the pipeline that is connected with the outside from top.
Temperature control system in this programme connects display system, and peristaltic pump is used to drive culture fluid.The folder holder is installed in the top of container, over against the peristaltic pump of below, is used for placing bioreactor; Support (6) is installed cell pool; Support (7) is the support that is used for installation pipeline.
The present invention was with Biotype artificial liver device structure compared was more reasonable in the past, have complete function, easy to operate, cost is low and safeguard simple advantage, also convenient and abiotic type artificial liver device combination.The present invention repeatedly uses in the zoopery of our artificial liver support system, and effect is fine.
Claims (2)
1, a kind of device that is applicable to artificial liver, comprise and support part and control section, it is characterized in that: described support sector divides and comprises: a transparent cube container (1), container upper end has 2～4 pipeline holes (8) that communicate with the external world, a peristaltic pump (3) is arranged at the bottom in the container, pipe passage is arranged in the peristaltic pump, the pipeline of artificial liver reactor is come in and gone out from peristaltic pump, top in the container has 1～2 to be used to install and the fixedly folder holder (4) of artificial liver reactor, and 1～2 support (6 that is used to settle artificial liver reactor and pipeline thereof is arranged around the container inner bottom part peristaltic pump, 7); Described control section comprises: a casing (11) that tightly is harmonious with above-mentioned transparent cube container, the face lower end that is harmonious has opening (12) to communicate, be used for leading to and the circulation of steam of control circuit, electric heater (9) is housed in the casing, heating apparatus and temperature control system (5) are installed in the below of transparent cube container (1), and box plate is provided with control display screen (2).
2, by the described a kind of device that is applicable to bioreactor of claim 1, it is characterized in that: the transparent cube container of described support part is to make with insulation material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100935250A CN100335142C (en) | 2004-12-24 | 2004-12-24 | Apparatus adapted for artificial liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100935250A CN100335142C (en) | 2004-12-24 | 2004-12-24 | Apparatus adapted for artificial liver |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1631337A true CN1631337A (en) | 2005-06-29 |
| CN100335142C CN100335142C (en) | 2007-09-05 |
Family
ID=34847747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100935250A Active CN100335142C (en) | 2004-12-24 | 2004-12-24 | Apparatus adapted for artificial liver |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100335142C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732770B (en) * | 2009-12-14 | 2012-04-25 | 浙江大学 | Dual-cavity liquid storage tank for biological artificial liver support system |
| CN109125830A (en) * | 2018-07-23 | 2019-01-04 | 南京医科大学 | A kind of intelligence auxiliary temperature control device and control method suitable for haemodialysis or purification |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997016527A1 (en) * | 1995-10-30 | 1997-05-09 | Cellex Biosciences, Inc. | Cultureware for bioartificial liver |
| JPH1033671A (en) * | 1996-07-24 | 1998-02-10 | Jms Co Ltd | Hollow fiber type artificial liver and its perfusion and cultivating system |
| AUPP108597A0 (en) * | 1997-12-22 | 1998-01-22 | Sheil, A G R Prof. | Liver support system |
| CN1137733C (en) * | 2000-06-29 | 2004-02-11 | 重庆西南医院 | Method and equipment for externally mixed biologic artificial liver |
| CN1178706C (en) * | 2001-04-28 | 2004-12-08 | 细胞生物技术有限公司 | Composite artificial liver supporting system and its usage |
| CN2638736Y (en) * | 2003-07-11 | 2004-09-08 | 浙江大学 | Heterozygous artificial liver supporting device |
| CN2778826Y (en) * | 2004-12-24 | 2006-05-10 | 浙江大学 | Device adapted for artificial liver |
-
2004
- 2004-12-24 CN CNB2004100935250A patent/CN100335142C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732770B (en) * | 2009-12-14 | 2012-04-25 | 浙江大学 | Dual-cavity liquid storage tank for biological artificial liver support system |
| CN109125830A (en) * | 2018-07-23 | 2019-01-04 | 南京医科大学 | A kind of intelligence auxiliary temperature control device and control method suitable for haemodialysis or purification |
| CN109125830B (en) * | 2018-07-23 | 2021-05-11 | 南京医科大学 | Control method of intelligent auxiliary temperature control device suitable for blood purification |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100335142C (en) | 2007-09-05 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Weihai Weigao Life Science & Technology Co., Ltd. Assignor: Zhejiang University Contract record no.: 2012330000164 Denomination of invention: Apparatus adapted for artificial liver Granted publication date: 20070905 License type: Exclusive License Open date: 20050629 Record date: 20120411 |