CN1630506A - Compositions for cleansing skin and treating acne - Google Patents

Abstract

A skin cleansing composition comprising: from about 0.1 to about 5 percent by weight of at least one anti-acne active ingredient; from about 1 to about 25 percent by weight of at least one alcohol; from about 0.1 to about 15 percent by weight of at least one solubilizer; and water is disclosed. The composition is stable and dries quickly, but does not make the skin feel dry after use.

Description

The compositions that is used for cleaning skin and treatment acne

Background of invention

1. invention field

The present invention relates to be used for the compositions of cleaning skin and treatment acne.Described compositions contains salicylic acid, contain that concentration of alcohol is low, physically stable and use after can not make skin feel dry.

2. prior art general introduction

Acne is the common disease that is caused by blackhead, hoary hair, pimple, pustule, cyst and various tuberosity and cicatrix.Acne occurs in face and upper arm back usually.Acne to small part is by bacterial theoretically, as the propionibacterium acne.For this reason, anti-acne products often contains and can kill or the active component of bacteria growing inhibiting.Know benzoyl peroxide and salicylic acid can be used as anti-acne active ingredient.

Acne for the patient be difficult to see and also usually cause puzzlement.For this reason and good hygienic habit, many people daily use skin clean product and anti-acne products.The skin clean product comprises astringent, toner etc.Anti-acne products comprises ointment, washing liquid etc.Astringent and toner formulation comprise anti-acne active ingredient sometimes.

Known skin clean product and anti-acne products contain water.Salicylic acid is poorly soluble in water.Therefore, when needs were allocated salicylic acid into cleaning product or anti-acne products, salicylic acid is retained in just became a kind of challenge in the solution.The common physical instability of described preparation, promptly salicylic acid can be separated out from solution.Because its poorly water-soluble, salicylic acid ethanol normal and suitable a large amount is prepared together, helps to dissolve salicylic acid.Term " the quite ethanol of a large amount " is meant the total restatement with preparation, the ethanol of 40-80 weight % as used herein.

Ethanol in the salicylic acid preparation also helps to make preparation can become dry fast on skin.Because alcoholic acid evaporation, described preparation is often dry very soon.But unfortunately, ethanol often makes skin become dry from the skin evaporation.In general, people like making after cleaning skin to keep moistening.Therefore, require the skin clean product to contain anti-acne active ingredient, but can not make skin feel dry after being to use.

People had done trial, and to develop the cleaning agent that does not contain ethanol but contain anti-acne active ingredient, still this preparation runs into several problems.The first is difficult to make stable formulation because salicylic acid tends to separate out from solution.Another problem is that preparation can not rapid draing owing to do not contain ethanol.When not containing alcoholic acid preparation and become dry fully, often have sticking sensation on the skin.

U.S. Patent No. 6,024,941 disclose and have contained vitamin A and at least a external skin therapeutic combination that is used for the stabilizing agent of vitamin A.Suitable stabilizers comprises salicylic acid compound and Polyethylene Glycol.It is said that said composition can be used for treating keratodermatitis and prevents or treat skin aging.Wherein do not have any about containing telling about and advising of the alcoholic acid physically stable skin cleansing compositions of anti-acne composition and low content or its advantage.

Therefore, all require to make the skin clean product that contains anti-acne active ingredient, this product physically stable and after using, can not make skin feel dry or sticking all the time.

Summary of the invention

We have found that to provide the skin clean that contains anti-acne active ingredient product, this product physically stable and can not make skin feel dry or sticking after using.The invention provides a kind of skin cleansing compositions, said composition contains at least a alcohol of at least a anti-acne active ingredient of the 0.1-5 weight % that has an appointment, about 1-25 weight %, at least a solubilizing agent and the water of about 0.1-15 weight %.

The detailed description of preferred implementation

The present invention relates to the skin cleansing compositions of physically stable, said composition contains at least a alcohol of at least a anti-acne active ingredient of the 0.1-5 weight % that has an appointment, about 1-25 weight %, at least a solubilizing agent and the water of about 0.1-15 weight %.In content of the present invention, term " physically stable " is meant that compositions is at room temperature transparent and can not be separated or form precipitation.

Skin cleansing compositions of the present invention contains at least a anti-acne active ingredient.Suitable anti-acne active ingredient includes but not limited to salicylic acid, sulfur, lactic acid, glycolic, acetone acid, carbamide, resorcinol, N-acetylcystein, tretinoin, benzoyl peroxide, eight pyrroles's former times health (octopirox), triclosan (triclosan), Azelaic Acid, phenoxyethanol, benzene oxygen propanol, flavonoid (flavinoids), their derivant and their mixture.Preferred salicylic acid and benzoyl peroxide.Salicylic acid most preferably.The amount of anti-acne active ingredient is about 0.1-5 weight % with total restatement of described compositions in the present composition, is preferably 0.5-2 weight %.

In compositions of the present invention, comprise a kind of alcohol at least.Described alcohol can be selected from ethanol, normal propyl alcohol, isopropyl alcohol, the tert-butyl alcohol and their mixture.The preferred ethanol that uses.The amount of alcohol is enough high in the present composition, makes using after described compositions cleans, and compositions can very fast exsiccation and can not made skin feel sticking, can be too not high yet so that use after make skin feel dry.The amount of alcohol is about 1-25 weight % with total restatement of described compositions in the present composition, should be about 5-20 weight %, more preferably 10-20 weight %.

In the present composition, comprise a kind of solubilizing agent at least, anti-acne active ingredient can not separated out under the normal storage condition from solution to stablize described compositions.Suitable solubilizing agent includes but not limited to propylene glycol, butanediol, hexanediol, Polyethylene Glycol (PEG), Tween-20, Tween-40, isocetyl polyoxyethylene ether-15, Arlasolve 200 (isoceteth-20), isocetyl polyoxyethylene ether-30 (isoceteth-30), sorbitol polyglycol ether-20 (sorbeth-20), sorbitol polyglycol ether-40 (sorbeth-40), PEG-40 Oleum Ricini and their mixture.

Most preferred solubilizing agent is PEG.Have been found that number of repeat unit can influence PEG as the performance of anti-acne active ingredient with solubilizing agent among the PEG.If number of repeat unit is too high or too low, it is muddy that described preparation will become, and physical instability.Usually, suitable PEG comprises having about 20-75 ethylene glycol repeat units, is preferably 20,32,40,55,60 and 75, is more preferably 20,32 and 40, preferably the PEG of 32 each and every one ethylene glycol repeat units.The amount of solubilizing agent is about 0.1-15 weight % with total restatement of described compositions in the present composition, should be about 0.5-10 weight %, better is about 1-5 weight %.

Also comprise water in the present composition.The amount of institute's water depends on the amount of required component in the preparation and any selective component.In general, the amount of water is about 60-99 weight % with total restatement of described compositions, should be about 75-85 weight %.

Can randomly comprise wetting agent, UV absorbent, pH regulator agent, emollient (skin soother), softening agent (emollient), antiseptic, regulator and spice in the skin cleansing compositions of the present invention.

Be contained in the softening agent in the present composition because it is retained in the ability that plays the wetting agent effect in skin surface or the horny layer, can reduce the outward appearance of peeling and improving skin.Typical softening agent comprises fatty ester, aliphatic alcohol, mineral oil, polyether siloxane copolymers etc.The example of suitable softening agent includes but not limited to polypropylene glycol (PPG)-15 stearyl ether, PPG-10 cetyl ether, PEG-10 octadecyl ether (steareth-10), PEG-8 oleyl ether (oleth-8), PPG-4 lauryl ether, vitamin e acetate, PEG-7 glyceryl cocos nucifera oil acid esters (cocoate), lanoline and their mixture.Preferred vitamin E acetas, PEG-7 glyceryl cocos nucifera oil acid esters and their mixture.When using, the amount of softening agent is about 0.01-5 weight % with total restatement of described compositions, should be about 0.1-2 weight %, better is about 0.1-1 weight %.

In the present composition, can use polyhydric alcohol as wetting agent.Described wetting agent helps to improve the effect of softening agent, reduces delamination, promotes the sensation of removing the firecoat of formation and improving skin.Suitable polyhydric alcohol includes but not limited to glycerol, ployalkylene glycol, the many alcohol of alkylene and their derivant, comprise propylene glycol, dipropylene glycol, polypropylene glycol, Polyethylene Glycol and their derivant, Sorbitol, hydroxypropyl Sorbitol, hexanediol, 1,3-dibutylene glycol, 1,2, the glycerol of 6-hexanetriol (hexanetriol), ethoxylation, propenoxylated glycerol and their mixture.The preferred glycerol that uses.When using, the amount of described wetting agent is about 0.1-5 weight % with total restatement of described compositions, should be about 0.1-3 weight %.

Added emollient in the present composition in the past.Suitable emollients includes but not limited to pantothenylol, bisabolol, allantoin and their mixture.When using, the amount of described emollient is about 0.01-0.75 weight % with total restatement of described compositions, should be about 0.01-0.1 weight %.

Added regulator in the present composition in the past.Suitable regulator includes but not limited to polydimethylsiloxane propyl group PG-betaine, dimethicone copolyol, poly quaternary ammonium compound (polyquaternium)-10 and their mixture.When using, the amount of described regulator is about 0.01-1 weight % with total restatement of described compositions, should be about 0.01-0.5 weight %.

The pH that also finds the present composition is influential to physical stability of such mixtures.Usually, the pH of the present composition is about 3-4, is preferably 3.25-3.75, is more preferably about 3.6.Described pH can be by using pH regulator agent qualified aspect cosmetics, such as but not limited to sodium citrate.The consumption of pH regulator agent depends on the initial pH of compositions and needs the volume of the compositions of adjusting.In general, the consumption of pH regulator agent is about 0.1-0.5 weight % with total restatement of described compositions, should be about 0.2-0.4 weight %.

Added the UV absorbent in the present composition in the past.Suitable UV absorbent includes but not limited to benzophenone and derivant, cinnamic acid and derivant thereof, pyrroles, imidazoles etc.When using, the amount of described UV absorbent is about 0.001-0.01 weight % with total restatement of described compositions.

Botanical such as aloe extract, Flos Chrysanthemi extract, Herba thymi vulgaris extract, rosemary extract etc. also can be used for compositions of the present invention.When using, the amount of described botanical is about 0.01-1 weight % with total restatement of described compositions, should be about 0.01-0.1 weight %.

Sensory agent (sensate) also can be used for compositions of the present invention as Herba Menthae lactate, menthol, Oleum Camphora, Herba Menthae, Eucalyptus oil, Herba Menthae oxygen base propylene glycol (menthoxypropanediol) etc.During use, the amount of described sensory agent is about 0.01-1 weight % with total restatement of described compositions, should be about 0.05-0.5 weight %.

Usually the adding antiseptic suppresses microbial growth in the compositions.Suitable antiseptic comprises benzoic acid and Quaternium-15 (can be from Dow Chemical Corporation ofMidland, Michigan buys with " Dowicil 200 ") in the adding present composition.Preferred benzoic acid.When using, the amount of described antiseptic is about 0.01-1 weight % with total restatement of described compositions, should be about 0.05-0.5 weight %.

For the purpose of aesthetics, added any spice in the present composition in the past.Suitable spice includes but not limited to Eucalyptus oil, artificial camphor oil, Oleum menthae, Oleum Caryophylli, Garden lavender, Flos Chrysanthemi etc.When using, the amount of spice is about 0.05-0.5 weight % with total restatement of described compositions, should be about 0.1-0.3 weight %.

For the purpose of aesthetics, also added coloring agent in the present composition in the past.In present technique, know suitable coloring agent and the typical content that uses.

The present composition can be used for cleaning skin and treatment acne.Described compositions can be used as liquid and provides, and uses Cotton Gossypii swab, cloth etc. to be coated on the skin.Perhaps as in known technology, described composition adsorbs and is sold with the form of cleaning wiping cloth (rags) on wiping cloth (rags).

The specific embodiment of the compositions of advantage of the present invention and the present invention's preparation is described by following examples.However, it should be understood that the present invention is limited by the described concrete limitation of each independent embodiment never, but limit by the scope of accessory claim book.

Used material among the embodiment

? Trade name	Active component	Supplier
			?Glycerine?916	Glycerol	Henkel
?Univul?MS-40	Benzophenone-4	BASF
			?Ritapan?DL	Pantothenylol	RITA
?Actiphyte?of?Aloe?Vera	Aloe extract	Active?Organics
			?Carbowax?PEG	Polyethylene Glycol	Union?Carbide
?Arlasolve?200	Arlasolve 200	Uniqema
			?Cetiol?HE	PEG-7 glyceryl cocos nucifera oil acid esters	Henkel
?Fresclat?MR	The Herba Menthae lactate	Haarmann&Reimer
			?Dow?Corning?345?Fluid	Cyclomethicone	Dow?Corning
?Abil?B?9950	Polydimethylsiloxane propyl group PG-betaine	Goldschmidt
			?Abil?AV?20HS	Silicone DC 556	Goldschmidt
?Abil?Wax?9801	The hexadecyldimethyl benzyl ammonium siloxanes	Goldschmidt
			?Abil?B?8832	Dimethicone copolyol	Goldschmidt
?Abil?B?8843	Dimethicone copolyol	Goldschmidt
			?Arlamol?E	The PPG-15 stearyl ether	ICI?Surfactants
?Procetyl?AWS	PPG-5-ceteth-20	Corda
			?Solubilisant?LRI	PPG-26-butyl polyoxyethylene ether-26 and PEG-40 castor oil hydrogenated	Wackherr
?Polymer?JR400	Poly quaternary ammonium compound-10	Amerchol
			?Tween?20	Polysorbate 20	Uniqema
?Carbomer?EX-518	Acrylate copolymer	BF?Goodrich

Embodiment 1

In the present embodiment, prepare oil phase and water respectively, mix then.Mix described sample and storage at room temperature.Monitor sample with eyes.For being considered to useful sample, described preparation is answered transparent and is not at room temperature had precipitation and separate out.The step of preparation sample is as follows: (all amounts are in weight %)

By mixing vitamin E acetas, Arlamol ^E and Dow Corning 345 Fluid and uniform mixing prepare described oil phase.Prepare water by in glass beaker, melting PEG 1450, add salicylic acid and be mixed to dissolving, adding ethanol and mix.In independent container, under agitation CarbomerEX-518 is added in the entry.The solution that will contain alcohol then adds and contains in the solution of water, and stirs the formation water.Then with oil phase and water mixing and stirring.Prepare following sample:

	?????????????????????????????? Sample number into spectrum
								Composition	??? 1	??? 2	??? 3	??? 4	??? 5	??? 6	??? 7
Vitamin e acetate	????0.1	????0.1	????0.1	????0.1	????0.1	????0.1	????0.1
								Dow?Corning?345?Fluid	????5	????9	????9	????9.75	????10	????9.75	????9.75
Arlamol?E	????5	????1	????0.5	????0.25	????0	????0.1	????0.1
								Water	????Qs	????qs	????Qs	????Qs	????qs	????qs	????Qs
Ethanol	????10	????10	????10	????10	????10	????10	????10
								Salicylic acid	????0.5	????0.5	????0.5	????0.5	????0.5	????0.5	????0.5
PEG?1450 *(thin slice)	????1	????0	????1	????1	????1	????1	????1
								Sodium citrate	????0	????0	????0	????0	????0.5	????0.37	????0.25
Carbomer?EX-518	????0	????0	????0	????0	????0	????0	????0.1

^*It is 1450 Polyethylene Glycol that PEG 1450=contains 32 each and every one ethylene glycol repeat units and molecular weight.

The physical stability of test sample.The result is as follows:

Sample 1-forms muddy emulsion, surpasses 3 hours and just occurs being separated

Sample 2-separates out salicylic acid when oil phase and water mixing

Sample 3-forms muddy emulsion, is separated less than just occurring in 3 hours

Sample 4-forms muddy emulsion, is separated less than just occurring in 3 hours

Sample 5-forms muddy emulsion, occurs rapidly during pH regulator being separated

Sample 6-forms muddy emulsion, occurs being separated in 5 minutes

Sample 7-forms muddy emulsion, occurs being separated

Embodiment 2

Press the following preparation of following prepared:

Add in the beaker water and glycerol and stirring.Melt PEG 1450, add salicylic acid and be mixed to dissolving and prepare pure phase.Under agitation alcohol is added in this solution.By mixing vitamin E acetas, vitamin A palmitic acid lipid, spice and Procetyl ^AWS or Arlasolve ^200 and mix and to prepare oil phase.To also stir in pure addition entry and the glycerol then.Described then oil phase adds in entry/pure phase mixture and stirs.

	?????????????????? Sample number into spectrum
					Composition	??? 8	??? 9	??? 10	??? 11 *
Vitamin e acetate	????0.1	????0.1	????0.1	????0.1
					Procetyl AWS	????1	????1.5	????0	????0
The vitamin A palmitic acid lipid	????0.1	????0.1	????0.1	????0.1
					Spice	????0.2	????0.2	????0.2	????0.2
Arlasolve 200	????0	????0	????1.5	????1.5
					Water	????86.6	????80	????80	????80
Ethanol	????10	????10	????10	????10
					Salicylic acid	????0.5	????0.5	????0.5	????0.5
PEG?1450	????1	????1	????1	????1
					Glycerol	????0.5	????0.5	????0.5	????0.5

^*To sample #11, a part of alcohol is added in the oil phase, mix each phase then.

The physical stability of test sample.The result is as follows:

The opaque emulsion of sample 8-

The opaque emulsion of sample 9-

Sample 10-transparency emulsion

Sample 11-muddiness, yellow oil phase are separated

Sample 10-is physically stable and transparent at room temperature

Embodiment 3 accelerated ageings research

Different according to season and geographical position, condition of storage also has nothing in common with each other.Therefore, test guide candidate preparation down at high temperature (condition of storage in summer) and low temperature (condition of storage in winter).

Following preparation carries out the accelerated ageing test.Concerning these researchs, at 4 ℃, room temperature (25 ℃), 40 ℃ and 50 ℃ of following stored samples.In addition, sample down stores minimum 24 hours at-4 ℃, at room temperature stores 24 hours then and estimates.This freezing/thaw and test triplicate altogether.By the eye examination sample.If be separated, become muddy, form precipitation or variable color then shows the sample failure.

	??????? Sample number into spectrum
			Composition	??? 12	??? 13
Vitamin e acetate	????0.1	????0.1
			The vitamin A palmitic acid lipid	????0.1	????0.1
Spice	????0.2	????0.2
			Arlasolve 200	????1.5	????1.5
Ethanol	????10	????10
			Salicylic acid	????0.5	????0.5
PEG?1450	????1	????1
			Water	????8.27	????85.30
Glycerol	????0.5	????0.5
			Sodium citrate	????0.25	????0.25
0.1%FD﹠C orange #4	????0.58	????0
			The blue #1 of 0.1%FD﹠C	????0	????0.55

The result is as follows:

Store after 5 days, sample 12 is transparent under 4 ℃ and room temperature, but through once freeze/thaw cycles after, become muddy down at 40 ℃, it is very muddy to become under 50 ℃.Sample 13 is transparent under 4 ℃ and room temperature, but through once freeze/thaw cycles after, become muddy down at 40 ℃, it is very muddy to become under 50 ℃.All samples are determined whether that by olfactory sensation the accelerated ageing storage has the difference of all not finding in adverse effect, the sample in office on any fragrance scent to spice.

Embodiment 4

Basic preparation is as follows: add in the beaker water and glycerol and stirring, the adding benzophenone also stirs.PEG 1450, salicylic acid, the pure and mild benzoic pre-composition of preparation fusing add in the aqueous mixtures described pre-composition and stirring, regulate pH to 3.5 with sodium citrate, add dyestuff then.Described basic preparation contains following composition (all in weight %): 10% ethanol, 1% glycerol, 0.005% benzophenone-4,0.5% salicylic acid, 1%PEG-1450,80% water, 0.1% benzoic acid, 0.035%FD﹠amp; C blue #1 (0.1% solution), 0.015%FD﹠amp; Yellow #10 (0.1% solution) of C and 0.35% sodium citrate.

Then by mix Herba Menthae lactate and spice and heating up to the fusing of Herba Menthae lactate, add solubilizing agent and stir and mixture added in the basic preparation and stir and prepare sample.The following sample of subsample preparation by described basic preparation:

	????????????????????????? Sample number into spectrum
							Composition	? 14	? 15	? 16	? 17	??? 18	??? 19
Basic preparation	??98.8	??99.1	??98.8	??93	????93	????93
							The Herba Menthae lactate	??0.1	??0.1	??0.1	??0.1	????0.1	????0.1
Spice	??0.2	??0.2	??0.2	??0.2	????0.2	????0.2
							Solubilisant?LRI	??0.9	??0	??0	??0	????0	????0
Arlasolve?200	??0	??0.6	??0.9	??0	????0	????0
							Procetyl?AWS	??0	??0	??0	??0.61	????0.90	????1.21

Sample 17 and 18 muddinesses.Sample 14,15,16 and 19 is transparent, and accelerated ageing research is carried out in storage.The result is as follows: store after one day all samples 14,15,16 and 19 transparent under 50 ℃ and room temperature.Sample 14 and 16 through once freeze/transparent after the thaw cycles, sample 15 and 19 through once freeze/muddy after the thaw cycles.

Embodiment 5

Water is added in the large beaker, add glycerol and stirring, add benzophenone and also stir, add sodium citrate and also stir.By fusing PEG-1450, add solubilizing agent and be heated to about 40 ℃ and add salicylic acid and stir to dissolve and prepare the salicylic acid pre-composition up to salicylic acid.Described mixture is cooled to 40 ℃, adds Herba Menthae lactate and stirring then, add vitamin e acetate and stirring, add benzoic acid and also stir, add pure and stirring, add spice and stirring up to dissolving.Add in the aqueous solution salicylic acid pre-composition and stirring then, add dyestuff and stirring then.

Sample contains 85.6% water, 1% glycerol, 0.005% benzophenone-4,1%PEG-1450,0.5% salicylic acid, 10% ethanol, 0.1% benzoic acid, 0.35% sodium citrate, 0.044%FD﹠amp; C blue #1 (0.1% solution), 0.0112%FD﹠amp; The yellow #10 (0.1% solution) of C, 0.1% Herba Menthae lactate, 0.2% spice, 0.1% vitamin e acetate and 0.9%Solubilisant LRI.Described preparation is a phase and transparent.After storing for 5 weeks, keep transparent at the sample of 4 ℃, 25 ℃, 40 ℃ and 50 ℃.

The comparison of embodiment 6-solubilizing agent

The following sample of step preparation according to embodiment 4:

	???????????????? Sample number into spectrum
				Composition	??? 20	??? 21	??? 22
Water	????85.7	????85.6	????80.6
				Glycerol	????1	????1	????1
Benzophenone-4	????0.005	????0.005	????0.005
				PEG?1450	????1	????1	????1
Salicylic acid	????0.5	????0.5	????0.5
				Ethanol	????10	????10	????1?5
Benzoic acid	????0.1	????0.1	????0.1
				Sodium citrate	????0.35	????0.35	????0.35
The blue #1 (0.1% solution) of FD﹠C	????0.023	????0.023	????0.023
				The yellow #10 (0.1% solution) of FD﹠C	????0.058	????0.058	????0.058
The Herba Menthae lactate	????0.1	????0.1	????0.1
				Spice	????0.2	????0.2	????0.2
Arlasolve?200	????0.9	????0.9	????0.9
				Vitamin e acetate	????0.1	????0.1	????0.1
Pantothenylol (70% activity)	????0	????0.071	????0.05 *

^*Use the pantothenylol powder to replace 70% active liquid.

Sample 20,21 and 22 is transparent, and sample 20 and 21 stores and carries out accelerated ageing research.The result is as follows: after storing for 4.5 weeks, sample 20 is transparent down room temperature, 4 ℃, 40 ℃ and 50 ℃.Sample 20 and 21 through freeze for three times/all transparent after the thaw cycles.

	????????? Sample number into spectrum
			Composition	??? 23	??? 24
Water	????81	????81
			Glycerol	????0.5	????0.5
Benzophenone-4	????0.005	????0.005
			PEG?1450	????1	????1
Salicylic acid	????0.5	????0.5
			Ethanol	????15	????15
Benzoic acid	????0.1	????0.1
			Sodium citrate	????0.35	????0.35
The blue #1 (0.1% solution) of FD﹠C	????0.014	????0.023
			The yellow #10 (0.1% solution) of FD﹠C	????0.035	????0.058
The Herba Menthae lactate	????0.1	????0.1
			Spice	????0.2	????0.2
Arlasolve?200	????0.6	????0
			Vitamin e acetate	????0.1	????0.1
Pantothenylol (powder)	????0.05	????0.05
			Tween?20	????0	????0.9
Actiphyte?of?Aloe	????0.05	????0.05
			Cetiol?HE	????0.1	????0

Sample 23 is transparent, therefore it is carried out accelerated ageing research.The result is as follows: after storing for 8 weeks, sample 23 freezes down and through 3 times room temperature, 4 ℃, 40 ℃, 50 ℃/and still transparent after the thaw cycles.

Sample 24 is opaque, therefore it is not carried out accelerated ageing research.

Embodiment 7-interpolation contains the dimethyl silica hydride compounds

The subsample of sample thief 22 is tested it and the compatibility that contains the chemical compound of dimethyl siloxane.Prepare described sample and look to add the clean-up performance whether chemical compound that contains dimethyl siloxane can improve preparation.

Add in the subsample and stirring by the chemical compound that will contain siloxanes.Be prepared as follows sample:

	??????????????????????????????? Sample number into spectrum
							? Composition	??? 25	??? 26	??? 27	??? 28	??? 29	??? 30
Sample 22 (subsample)	????99.9	????99.9	????99.5	????99.995	????99.9	????98.75
							?Abil?B?8832	????0.1	????0	????0	????0	????0	????0
?Abil?B?8843	????0	????0.1	????0.5	????0	????0	????0
							?Polymer?JR400	????0	????0	????0	????0.005	????0	????0
?Abil?B?9950	????0	????0	????0	????0	????0.1	????0
							Glycolic (glycolic)	????0	????0	????0	????0	????0	????1
Sodium citrate	????0	????0	????0	????0	????0	????0.25

Sample 25 muddinesses.Sample 27 slight dim shapes.Sample 26,28 and 29 is transparent.Some samples are coated onto on people's the arm.With these sample cleanings with sample 22 cleansing phases ratio, do not feel any difference.These samples are not carried out accelerated ageing research.Be determined by experiment afterwards when adding the salicylic acid pre-composition after just adding ethanol, the described compound dissolution that contains dimethyl siloxane gets best.

Embodiment 8-regulates the content of Herba Menthae lactate and spice

Prepare a series of sample and optimize the content of Herba Menthae lactate and spice in the preparation.Pre-composition by preparation Carbowax PEG-1450, Arlasolve200, salicylic acid, vitamin e acetate, Cetiol HE, benzoic acid, Frescolat MR, ethanol and spice and water, glycerol, Univul MS-40, sodium citrate, FD﹠amp; C blue #1 (0.1% solution), FD﹠amp; The major ingredient of C yellow #10 (0.1% solution), Ritapan DL and Actiphyteof Aloe Vera mixes major ingredient and pre-composition then and prepares described sample.Prepare following sample:

	??????????????????? Sample number into spectrum
					Composition	??? 31	??? 32	??? 33	??? 34
Water	????80.96	????80.96	????80.96	????80.96
					Glycerol	????0.5	????0.5	????0.5	????0.5
Univul?MS-40	????0.005	????0.005	????0.005	????0.005
					Sodium citrate	????0.35	????0.35	????0.35	????0.35
The blue #1 (0.1% solution) of FD﹠C	????0.023	????0.023	????0.023	????0.023
					The yellow #10 (0.1% solution) of FD﹠C	????0.059	????0.059	????0.059	????0.059
Ritapan?DL	????0.05	????0.05	????0.05	????0.05
					Actiphyte?of?Aloe?Vera	????0.05	????0.05	????0.05	????0.05
Carbowax?PEG-1450	????1	????1	????1	????1
					Arlasolve200	????0.9	????0.9	????0.9	????0.9
Salicylic acid	????0.5	????0.5	????0.5	????0.5
					Vitamin e acetate	????0.1	????0.1	????0.1	????0.1
Cetiol?HE	????0.1	????0.1	????0.1	????0.1
					Benzoic acid	????0.1	????0.1	????0.1	????0.1
Frescolat?MR	????0.1	????0.1	????0.075	????0.075
					Ethanol	????15	????15	????15	????15
Spice	????0.2	????0.15	????0.15	????0.1

At room temperature, 4 ℃, 40 ℃ and 50 ℃ of following stored samples and check its abnormal smells from the patient.Through behind the certain hour, except 50 ℃ down, do not find that changing appears in the abnormal smells from the patient of any sample, all 4 samples all have slight alcohol flavor.Through freeze for three times/thaw cycles after, except sample 33, do not find that changing appears in the abnormal smells from the patient of any sample, through finding after twice and three circulations that slight alcohol distinguishes the flavor of.

The influence of different PEG of embodiment 9-and pH

Prepare following sample with the relatively influence of different molecular weight PEG.The pH of regulon sample determines the influence of pH to sample stability.

	????????? Sample number into spectrum
			Composition	??? 35	??? 36
Water	????74.2	????80.49
			Versene?NA	????0.1	????0.1
Glycerol	????0.5	????0.5
			Univul?MS-40	????0.005	????0.005
Ritapan?DL	????0.05	????0.05
			Actiphyte?of?Aloe?Vera	????0.05	????0.05
Carbowax?PEG-1450	????0	????1
			Carbowax?PEG-3350	????1	????0
Arlasolve200	????0.9	????0.9
			Salicylic acid	????0.5	????0.5
Vitamin e acetate	????0.1	????0.1
			Cetiol?HE	????0.1	????0.1
Frescolat?MR	????0.1	????0.1
			Ethanol	????15	????15
Abil?B?9950	????0.05	????0.05
			Spice	????0.15	????0.15
Sodium citrate (25% solution)	????0.20	????0.34

Sample 35 and 36 carries out the accelerated ageing test.Use sodium citrate to regulate the pH of sample 35 and 36 subsamples.Concerning sample 35, prepare three subsamples: one pH is 3.23, another pH is 3.62, and a pH is 3.91 again; Concerning sample 36, prepare two subsamples: one pH is 3.63, and another pH is 3.89.Sample behind the described pH regulator also carries out the accelerated ageing test.

Store after 5 weeks, pH is 3.23 the at room temperature slight muddiness of sample 35, but transparent under 4 ℃, 40 ℃ and 50 ℃.It is transparent down room temperature, 4 ℃, 40 ℃ and 50 ℃ that pH is 3.62 sample 35.It is transparent down room temperature and 50 ℃ that pH is 3.91 sample 35, but 4 ℃ and 40 ℃ of following cloudy.The result who freezes/thaw research is as follows: at pH is 3.23 o'clock, separates out crystal after the circulation for the second time, is 3.63 o'clock at pH, and sample keeps transparent after three circulations, is 3.91 o'clock at pH, the equal cloudy of sample after each circulation.

Store after 5 weeks, it is transparent down room temperature, 4 ℃, 40 ℃ and 50 ℃ that pH is 3.63 sample 36.PH is 3.89 sample 36 cloudy at room temperature, dim shapes occur at 40 ℃, and is transparent down at 50 ℃.It is transparent down room temperature and 50 ℃ that pH is 3.91 sample 35, but 4 ℃ and 40 ℃ of following cloudy.The result who freezes/thaw research is as follows: concerning pH3.63, sample keeps transparent after three circulations, concerning pH3.89, first and second circulation times occur dim shape, becomes turbid after the circulation 3/opaque.

The molecular weight of PEG and the pH of sample are influential to the preparation physical stability.

Claims (12)

1. skin cleansing compositions, said composition contains:

At least a anti-acne active ingredient of about 0.1-5 weight %;

At least a alcohol of about 1-25 weight %;

At least a solubilizing agent of about 0.1-15 weight %;

And water.

2. the described skin cleansing compositions of claim 1 is characterized in that described anti-acne agents is selected from salicylic acid, sulfur, lactic acid, glycolic, acetone acid, carbamide, resorcinol, N-acetylcystein, tretinoin, benzoyl peroxide, eight pyrroles's former times health, triclosan, Azelaic Acid, phenoxyethanol, benzene oxygen propanol, flavonoid, their derivant and their mixture.

3. the described skin cleansing compositions of claim 2 is characterized in that described anti-acne agents is selected from salicylic acid, benzoyl peroxide, their derivant and their mixture.

4. the described skin cleansing compositions of claim 1 is characterized in that described solubilizing agent is selected from propylene glycol, butanediol, hexanediol, Polyethylene Glycol, Tween-20, Tween-40, isocetyl polyoxyethylene ether-15, Arlasolve 200, isocetyl polyoxyethylene ether-30, Pyrusussuriensis polyglycol ether-20, Pyrusussuriensis polyglycol ether-40, PEG-40 Oleum Ricini, polypropylene glycol-5 ceteth-20 and their mixture.

5. the described skin cleansing compositions of claim 4 is characterized in that described solubilizing agent is selected from Polyethylene Glycol, PEG-40 Oleum Ricini, polypropylene glycol-5 ceteth 20 and their mixture.

6. the described skin cleansing compositions of claim 5 is characterized in that described solubilizing agent is the Polyethylene Glycol that contains 20-40 the ethylene glycol repeat units of having an appointment.

7. the described skin cleansing compositions of claim 6 is characterized in that described Polyethylene Glycol contains 32 repetitives.

8. the described skin cleansing compositions of claim 7 is characterized in that described alcohol is ethanol.

9. the described skin cleansing compositions of claim 8 is characterized in that described anti-acne agents is a salicylic acid.

10. the described skin cleansing compositions of claim 8 is characterized in that the amount of described anti-acne agents is about 0.5-2 weight %

11. the described skin cleansing compositions of claim 9 is characterized in that alcoholic acid amount is about 10-20 weight %.

12. the described skin cleansing compositions of claim 10 is characterized in that described compositions also contains at least a softening agent.