CN1628744A

CN1628744A - Externally applied plaster for treating hypertension

Info

Publication number: CN1628744A
Application number: CN 200310123626
Authority: CN
Inventors: 王建民
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-12-15
Filing date: 2003-12-15
Publication date: 2005-06-22
Anticipated expiration: 2023-12-15
Also published as: CN1294967C

Abstract

Disclosed is an externally applied plaster for treating hypertension, which is prepared from hooked uncaria, selfheal, abalone shell, salsola, gastrodia tuber, evodia rutaecarpa, eucommia bark, buthus martensi kirsch, centipede, earthworm, magnetite and cinnabar.

Description

A kind of externally used plaster medicine for the treatment of multiple hypertension

What the present invention relates to is a kind of subsides medicine of inner disease outer treat, externally used plaster medicine that particularly can the balance hypertension symptom.

At present the hypertensive means of treatment mostly are and have an injection and adhere to taking medicine for a long time, take medicine for a long time and great dependence and untoward reaction arranged, also injure taste mostly, at present a lot of patients wish to have and a kind ofly do not take medicine, do not have an injection, side effect externally used plaster medicine little and easy to use is treated hypertension, satisfies the demands.

The purpose of this invention is to provide a kind of inner disease outer treat, can treat the externally used plaster medicine of multiple hypertension.

The object of the present invention is achieved like this: select Chinese medicine for use: Ramulus Uncariae Cum Uncis, Spica Prunellae, Concha Haliotidis, Herba Salsolae Collinae, Rhizoma Gastrodiae, Fructus Evodiae, the Cortex Eucommiae, Radix Gentianae, Herba Taxilli, Radix Angelicae Sinensis, Radix Scrophulariae, Fructus Ligustri Lucidi, Fructus Lycii, Fructus Schisandrae Chinensis extract concentrated extract with known supercritical extraction process method.Ramulus Uncariae Cum Uncis extracts and is no more than 20 minutes.Scorpio, Scolopendra, Lumbricus, Magnetitum, Cinnabaris, Os Draconis, Concha Ostreae, high temperature sterilization microwave drying grind 120 order powder and last concentrated extract mixes; Select Western medicine for use: cyclopenthiazide powder and penetration enhancer Laurel nitrogen ketone powder, corrosion agent carboxymethyl Starch Sodium and matrigel, to carry out comprehensive mix homogeneously standby with preceding Chinese medicine.Mix

After closing ointment and mixing up, be applied in the intermediary pit of adhesive plaster, the pit of design compacting is 40 millimeters of diameters in the middle of the adhesive plaster, recessed dark 3 millimeters, coat repave after the pressing lid layer hyaline membrane in the ointment surface these product.

Good effect of the present invention is: prescription is selected for use: Ramulus Uncariae Cum Uncis is used for suppressing vasomotor center by Vagal Afferent Fibers and causes blood pressure lowering.Spica Prunellae is used for removing heat from the liver, the rising for the treatment of the liver fire, headache, dizzy, blood pressure lowering.The Concha Haliotidis removing fire from the liver, only dizzy, treatment hypertension.The insomnia of Herba Salsolae Collinae (pricking fluffy) treatment hypertension dizziness.Rhizoma Gastrodiae be used for the treatment of dizziness that the liver-fire rising causes, dizzy, headache, ear toot.Fructus Evodiae is used for the high Sheng person's of liver hypertension, suppressing the hyperactive liver sun, blood pressure lowering.The Cortex Eucommiae can keep the stable persistency of blood pressure lowering.Radix Gentianae be used for the treatment of the hypertension dizziness ear toot, fidgety, easily pardon.The Radix Angelicae Sinensis nourishing YIN and invigorating YANG, also can eliminate the dizzy ear of climacteric hypertension patient toot, vexedly sleep less, impetuous irritability, spiritlessness and weakness.The Radix Scrophulariae clearing away heat and cooling blood, replenishing YIN and removing heat, blood pressure lowering.Fructus Ligustri Lucidi is used for the treatment of hypertension deficiency of the liver and kindey, YIN-deficiency type soreness of the waist and knees, rocky symptom.The Fructus Lycii nourishing the liver and kidney, nourishing the liver to improve visual acuity.Fructus Schisandrae Chinensis: abnormal hypertension is had Accommodation, can make transference cure or improvement such as insomnia, headache, dizziness and blurred vision, heart beating, seminal emission again.Scorpio suppresses vasomotor center, blood vessel dilating, directly suppresses heart and also lasting to adrenolytic.Keep stabilizing blood pressure normally to reach the shake of control two handss.The Scolopendra spasmolytic effect that is used to relieve dizziness, high fever, infantile convulsions, epilepsy, etc.Lumbricus is used to directly act on the above central nervous system of spinal cord or influences maincenter reflectingly by some sensory receptor, causes the expansion of part visceral vessel, causes blood pressure drops, and prevents the shake of two handss.Magnetitum is used for tranquillizing and allaying excitement, control is nervous, insomnia, dizzy, ear toot, headache.Tranquilizing cinnabar acts on nervous, insomnia, mad dry infantile convulsion.That Os Draconis deficiency of YIN liver-yang hyperactivity causes is fidgety, insomnia, night sweat, the vertigo, and controls seminal emission.The Concha Ostreae nourishing YIN for suppressing the hyperactive YANG is controlled having a dizzy spell in the hypertension hyperactivity of YANG due to deficiency of YIN, soreness of the waist and knees.Cyclopenthiazide is a western medicine of depressurization, assists blood pressure lowering.Penetration enhancer Laurel nitrogen ketone and corrosion agent carboxymethyl Starch Sodium make Chinese and western drugs fully permeate at in-vitro percutaneous skin and are beneficial to absorption.Matrigel is that adjuvant plays the sticking auxilliary effect of medicine that keeps.The pit that is pressed in the middle of the adhesive plaster mainly plays the medicine effect of difficult drop-off therein that makes, and it is convenient to use, and reaches the application purpose of curing the disease preferably.

The present invention fills a prescription as follows: (pasting by 53): Ramulus Uncariae Cum Uncis 30 grams, Spica Prunellae 30 grams, Concha Haliotidis 60 grams, Herba Salsolae Collinae 50 grams, Rhizoma Gastrodiae 20 grams, Fructus Evodiae 10 grams, the Cortex Eucommiae 40 grams, Radix Gentianae 12 grams, Herba Taxilli 40 grams, Radix Angelicae Sinensis 15 grams, Radix Scrophulariae 30 grams, Fructus Ligustri Lucidi 40 grams, Fructus Lycii 30 grams, Fructus Schisandrae Chinensis 30 grams, Scorpio 10 grams, Scolopendra 30 grams, Lumbricus 30 grams, Magnetitum 60 grams, Cinnabaris 1 gram, Os Draconis 30 grams, Concha Ostreae 30 grams, cyclopenthiazide 17.5 grams, 10% Laurel nitrogen oxadiazon, 10 grams, 7% carboxymethyl starch sodium, 7 grams, matrigel 10 grams.

Combined formulation describes embodiment and medical mechanism in detail.

By prescription hook taking rattan 30 grams, extract separately and be no more than 20 minutes, but industrialized mass production extract, blend by formula proportion when converting system, the extracting juice ratio is 5: 1, promptly 30 grams extract concentrated juice 6 grams.Spica Prunellae 30 grams, Concha Haliotidis 60 grams, Herba Salsolae Collinae 50 grams, Rhizoma Gastrodiae 20 grams, Fructus Evodiae 10 grams, the Cortex Eucommiae 40 grams, Radix Gentianae 12 grams, Herba Taxilli 40 grams, Radix Angelicae Sinensis 15 grams, Radix Scrophulariae 30 grams, Fructus Ligustri Lucidi 40 grams, Fructus Lycii 30 grams, Fructus Schisandrae Chinensis 30 grams, the mixed extraction concentrated juice, also but the mixed industrial batch process is extracted, blend by formula proportion when converting system, the extracting juice ratio is 5: 1, and promptly totally 377 grams extract concentrated juice 75 grams.Scorpio 10 grams, Scolopendra 30 grams, Lumbricus 30 grams, Magnetitum 60 grams, Cinnabaris 1 gram, Os Draconis 30 grams, Concha Ostreae 30 gram microwave drying high temperature kill mattress, and single is ground into 120 order powder and mixes totally 191 grams.Western medicine cyclopenthiazide 17 gram powder, 10% Laurel nitrogen ketone powder, 10 grams, 7% carboxymethyl starch sodium powder 7 gram, behind the above uniform mixing with matrigel 10 grams totally 44.5 grams uniformly mix into mastic again, about about 310 grams, 5 grams are got in every subsides, be applied in the middle of the adhesive plaster, be compressed on 40 millimeters of diameters, in dark 3 millimeters pits, can make about 60 subsides, applanation surface bedding layer of transparent film.

After medical mechanism in its prescription was stated, Ramulus Uncariae Cum Uncis: sweet in the mouth, cold nature was gone into liver, pericardium footpath.Clinical practice is given birth in liver-wind, dizzy, the headache due to pathogenic wind-heat of having a headache, child's liver-heat night cry.Being used for the treatment of hypertension in we has certain curative effect, finds that blood pressure lowering is not influenced by atropine when analyzing the decompression principle of Ramulus Uncariae Cum Uncis decoct, and behind the excision vagus nerve, hypotensive effect promptly significantly weakens.The Bufo siccus heart that exsomatizes there is not remarkable inhibition.Exempt from also do not have the effect of direct blood vessel dilating on the perfusion of ear stripped.So think that its blood pressure lowering is that reflexive (passing through Vagal Afferent Fibers) inhibition vasomotor center causes.Heavy dose then plays direct repression to the latter.Spica Prunellae: bitter, hot, cold in nature, go into liver, gallbladder meridian.Be applied in this product conjunctival congestion and swelling pain, the headache dizzy; Herb includes triterpenoid saponin and caffeic acid, alkaloid and water soluble salt, and this product hypotensive effect has substantial connection with contained inorganic salt wherein, modernly clinically manyly treats hypertension with this product, removing heat from the liver, headache and dizzy.Herba Salsolae Collinae (pricking fluffy): salty in the mouth is cold in nature, is the folk tradition Altace Ramipril, and can controls hypertension dizziness, insomnia.Rhizoma Gastrodiae, acrid in the mouth is warm in nature, this product is applied to liver-wind stirring up internally, liver-yang is dizzy, intractable headache, arthralgia pain limb fiber crops, convulsion are twitched bitterly, headache due to deficiency of blood, dizzy, numb hand and foot, tic and apoplexy from the beginning of, include vanillyl alcohol, vanillin, retinoid material, glycoside, crystallinity neutral substance and micro-biological alkali, phlegmatic temperament.Fructus Evodiae: acrid in the mouth, hardship, hot in nature, go into liver, spleen, stomach warp.Include Fructus Evodiae lactone, rutaecarpine, rutaecarpin, analgesia is arranged, the effect of blood pressure is breathed in slight effect; It is remarkable that the hypertension effect is controlled in external application.Fructus Evodiae is ground into powder, is transferred with vinegar and apply two arches of the foot, and the general back blood pressure that applies can descend doing well,improving.The Cortex Eucommiae, sweet in the mouth, warm in nature, go into liver, kidney channel; It is applied to insufficiency of kidney-YANG, lumbago, deficiency of the liver and kindey in this product, and the muscles and bones flaccidity is soft etc.; It contains gutta-percha 6-10%, and root bark contains 10-12%, glucoside, alkaloid, pectin, fat, organic acid, VC etc.; Decoct has the persistency hypotensive effect to animal.Radix Gentianae: bitter in the mouth, cold in nature, go into the liver and gall urinary bladder channel.Effect heat clearing and damp drying, liver heat removing gallbladder fire; It is applied to treat conjunctival congestion deafness, hypochondriac pain bitter taste in this product; It contains gentiopicrin, erythricine etc.; Erythricine has sedation, also can make muscular flaccidity, and anesthetized animal is had hypotensive effect.Existing clinical be used for this product treatment hypertension dizziness, ear toot etc. disease.Herba Taxilli: contain Herba Taxilli glycoside and a small amount of Quercetin etc.; It has certain sedation to the central nervous system, and its ethanol water-leach liquor and 30% alcohol leaching liquid are all to the anesthetized animal effect of bringing high blood pressure down.Radix Angelicae Sinensis: go into liver, heart spleen channel, include volatile oil, its Main Ingredients and Appearance has butylidenephthalide, the positive pentanone of adjacent antelope base benzene, VB12, VA class material.Influence has hypotensive effect to various preparations to blood circulation; Can treat again climacteric syndrome can eliminate dizzy ear toot, vexedly sleep less, impetuous irritability, symptoms such as spiritlessness and weakness.Radix Scrophulariae: bitter in the mouth, sweet, saltiness are cold, go into lung, stomach, kidney channel; It contains alkaloid, saccharide, sterol, aminoacid, carotene etc., and hypotensive effect is arranged, and is more obvious to renal hypertension.In pericardium falls, clearing away heat and cooling blood; Treatment fever of the body hypertension, diseases such as xerostomia crimson tongue.Fructus Ligustri Lucidi: sweet-bitter flavor is cool in nature, goes into liver, kidney channel, and in cloudy liver renal deficiency type to hypertension, the treatment hepatic and renal YIN deficiency, soreness of the waist and knees is had a dizzy spell, diseases such as early whitening of beard and hair.Be used for deficiency of the liver and kindey, poor vision simultaneously, the blurring of vision of treatment deficiency of yang of liver and kidney, poor vision.Include oleanolic acid, mannitol, glucose, Palmic acid, stearic acid, oleic acid, linoleic acid.Fructus Lycii: sweet in the mouth is flat, goes into liver, and kidney channel, this product are applied to the hypertension deficiency of the liver and kindey, blurring of vision, poor vision, the disease of having a dizzy spell.Fructus Schisandrae Chinensis: sour in the mouth, sweet, warm in nature, go into lung, kidney, heart channel; Act on the not solid disease of suffering from a deficiency of the kidney, include citric acid, malic acid, volatilization wet goods, and help cardiomotility, mainly undesired blood pressure is had Accommodation; It can treat the neurasthenia, can make that the patient has a sleepless night, has a headache, dizzy, dim eyesight and heart beating, seminal emission transference cure or improvement, thereby gets well.Scorpio: acrid in the mouth is flat poisonous, goes into Liver Channel, not only treats the hypertension deficiency of YIN and rheumatoid arthritis stubborn removing obstruction in the collateral to relieve pain, and two handss are shaken, and the intractable migraine and general headache is had therapeutical effect.Blood circulation also had lasting hypotensive effect.It includes the scorpion venom proteinoid, also contains trimethylamine, taurine, palmitic acid, stearic acid, cholesterol.Scolopendra: acrid in the mouth is warm in nature, goes into Liver Channel, contains class Venenum apis toxic component etc.Specially control migraine and general headache in this product.Especially intractable headache also has buck functionality.Lumbricus: salty in the mouth is cold in nature, goes into liver, spleen lung meridian, includes the analgesic alkali of various Lumbricuss, lumbricin; Terrestro-lumbrolysin.And contain alanine, valine, lysine etc.; It mainly plays slow and persistent hypotensive effect in this product; Its decompression principle is owing to directly act on the above central nervous system of spinal cord, or influences maincenter reflectingly by some interoceptor and cause the expansion of part visceral vessel, causes blood pressure drops.Lumbricus powder has certain curative effect to essential hypertension.Magnetitum: acrid in the mouth, salty, cold in nature, go into the heart, liver, kidney channel; It contains ferroso-ferric oxide, acts on dizziness due to hyperactivity of liver-YANG, nephrasthenia deafness in this product, is used for the having a dizzy spell of excessive rising of liver-YANG, impetuous irritability in hypertension, strengthens the effect of suppressing the hyperactive liver and subsiding YANG.Magnetitum is joined Cinnabaris, control nervous, the insomnia of hyperactivity of YANG due to deficiency of YIN hypertension, dizzy, ear toot, disease such as headache.Cinnabaris: sweet in the mouth is cold in nature, goes into heart channel; Tranquilizing mind is used to have palpitation, insomnia, mad dry, infantile convulsion etc.Concha Ostreae: salty in the mouth, cold nature is gone into liver, kidney channel, is used for dizziness due to hyperactivity of liver-YANG, malaise also is used for the treatment of deficiency of kidney yin in this product, the kidney failing to nourish the liver, hyperactivity of YANG due to deficiency of YIN have a dizzy spell soreness of the waist and knees.Os Draconis: sweet in the mouth, puckery, cold nature is gone into the heart, Liver Channel; Be used for malaise in this product, dizziness due to hyperactivity of liver-YANG; Cure mainly the trouble of various abnormal minds, and be used for diseases such as the having a dizzy spell for the treatment of the liver sun rising, fidgety irritability.Include calcium carbonate, calcium phosphate, ferrum, potassium, sodium, chlorine etc.Cyclopenthiazide: be Western medicine depressor, play the secondary buck effect among the present invention.Laurel nitrogen ketone: be penetration enhancer, be used for transdermal penetration, improve the absorption curative effect.Carboxymethyl starch sodium: play corrosion agent effect.Matrigel: adjuvant keeps the sticking auxilliary absorption that is beneficial to.

Claims

1, the multiple hypertensive externally used plaster medicine of a kind of treatment is characterized in that being prepared from order to the below method, selects Chinese medicine for use: Ramulus Uncariae Cum Uncis 30 grams extract and are no more than 20 minutes, but the single industrialized mass production is extracted, convert when system, blend by formula proportion, the extracting juice ratio be 5: 1 promptly 30 grams get concentrated juice 6 grams.Spica Prunellae 30 grams, Concha Haliotidis 60 grams, Herba Salsolae Collinae 50 grams, Rhizoma Gastrodiae 20 grams, Fructus Evodiae 10 grams, the Cortex Eucommiae 40 grams, Radix Gentianae 12 grams, Herba Taxilli 40 grams, Radix Angelicae Sinensis 15 grams, Radix Scrophulariae 30 grams, Fructus Ligustri Lucidi 40 grams, Fructus Lycii 30 grams, Fructus Schisandrae Chinensis 30 grams, the mixed extraction concentrated solution, but also the mixed industrial batch process is extracted, and blends by formula proportion when converting system, the extracting juice ratio is 5: 1 i.e. totally 377 grams, concentrates meter 75 grams, Scorpio 10 grams, Scolopendra 30 grams, Lumbricus 30 grams, Magnetitum 60 grams, Cinnabaris 1 gram, Os Draconis 30 grams, Concha Ostreae 30 grams, carry out high temperature sterilization, microwave drying grinds to form 120 order powder totally 191 grams, Western medicine: cyclopenthiazide 17 gram powder; 10% Laurel nitrogen ketone powder, 10 grams, 7% carboxymethyl starch sodium powder, 7 grams, more than mixed uniformly and matrigel 10 grams totally 44.5 grams, uniformly mix into again about about 310 grams of mastic, be suppressed with 40 millimeters of diameters in the middle of being applied to adhesive plaster, in the dark 3 millimeters pit, every adhesive plaster 5 grams, applanation surface, bedding layer of transparent film.