CN1628561A

CN1628561A - Combination for releasing lassitude and its preparation method and uses

Info

Publication number: CN1628561A
Application number: CNA2004100674532A
Authority: CN
Inventors: 李闻捷; 王锡智; 黄才国; 张军
Original assignee: Shanghai Changhai Hospital
Current assignee: Shanghai Changhai Hospital
Priority date: 2004-10-25
Filing date: 2004-10-25
Publication date: 2005-06-22

Abstract

The invention provides a composition for rapidly alleviating fatigue and enhancing resistance, wherein the composition comprises electrolyte, trace elements and nutrients, the preparing process comprises the steps of batching by determined proportion, charging trace elements such as copper, Zinc, and meeting the formula designed requirement.

Description

A kind of composition and method of making the same and purposes that is used for fatigue alleviating

Technical field

The present invention relates to beverage, food and medicine technical field, specifically a kind of composition and method of making the same and purposes that relates to alleviation, relieving fatigue and stamina intensifying, a kind of composition and method of making the same and purposes that relates to quick alleviation, relieving fatigue and stamina intensifying of more specifically saying so.

Background technology

(1) overview

21 century, fashion is not only in body-building, a kind of especially trend, a kind of life attitudes, and what its was represented is positive healthy lifestyles.This life style has comprised the problem of every aspect, for example after perspiring in a large number in a large amount of physical works, strenuous exercise or hot summer, how to alleviate and to remove fatigue fast is a focus that is subjected to various circles of society's common concern, for professional person such as athlete etc., it is more important that this solution just seems.At present, relatively one of solution of main flow is exactly to carry out suitable fluid infusion at the volley or after the motion, as takes especially sports drink etc. of beverage, and this also is a considerable link.

The beverage types of selling on the market is various, and wherein soft drink mainly is divided into drinks, soda pop, fruit drink three major types.According to the new regulation of international beverage industry association, functional drink is meant soft drink with health role.

For this notion of drinks, mainly be meant the beverage of energy building body, raising physical function in the eyes in many ordinary consumer.In fact, the expert points out that drinks is the health product that occur with drink form, why is called " drinks ", is address in line with international standards.Except the product of building body extra-nutrition class, also comprise product for invigorating function of brain, energy matter, can shorten the product of tired time etc.Drinks can be divided into three classes at present, i.e. sports drink, nutrients beverage and other functional drinkss.At present, the global drinks market structure is: sports drink 68%, nutrients beverage 25%, other 7%.Early 1990s, global drinks only has the sales volume less than 2,000,000,000 dollars; World's drinks market sales revenue had reached 4,700,000,000 dollars in 2000, estimated to be increased to 12,000,000,000 dollars by 2007.

On Chinese domestic market, can trace back to nineteen ninety-five to the understanding of drinks and get the red drink heavily material of " be stranded to have tired out and drunk red cattle " slogan, but beverage market at that time is single relatively, and the drinks of outstanding health-care effect in 2004 becomes fresh combatants on the market.In recent years, China beverage industry development rapidly, the speed increment with average annual 20%, the kind style of beverage constantly updates, and emerges large quantities of scales, enterprises that brand recognition is high of going up.Compare with world developed country, at present the consumption per head of China's drinks only is 0.5 kilogram every year, apart from the whole world per capita 7 kilograms consumption figure still have than large space, therefore the drinks market of China is huge.

(2) technical standard of Chinese sports drink

Existing panoramic sports drink appears on the market on the market now, most of sports drinks are by liquid being provided and improving motor capacity with sugared makeup energy, wherein electrolyte that contains in the liquid and vitamin can be regulated function of human body rapidly, are adapted at drinking after strong movements, human body are sweat in a large number.From high-energy solid beverage, body-building drink that the Chinese till now national professional contingents at different levels of the Gastorade of external NBA are in fashion, these all are a kind of novel beverage---sports drinks in fact.

As far back as the eighties in 20th century, just there is businessman to propose the notion of sports drink.Sports drink is the important kind of drinks.It is generally acknowledged that sports drink is nonalcoholic, prove that by analysis of science it can physical strength reinforcing and the recovery of quickening post exercise in being engaged in the process of motion.

1994, China national State Administration of Quality Supervision, Inspection and Quarantine has issued the national standard (revision in 2000) of sports drink, and in the standard sports drink is defined as: the component of nutrient and content can adapt to the athlete or participate in physical training, physical work crowd's physiological characteristics, the soft drink of special dietary needs.

The composition of nutrient and content in the sports drink should meet any requirement more than or in the following table.

The composition of nutrient and content in table 1, the sports drink

The nutrient composition	Content in the finished product
The nutrient composition	Content in the finished product	Ascorbic acid (mg/kg)≤	????120
Thiamine and derivant thereof (mg/kg)	????3～5	Ascorbic acid (mg/kg)≤	????120
Thiamine and derivant thereof (mg/kg)	????3～5	Riboflavin and derivant thereof (mg/kg)	????2～4
Sodium (mg/kg)	????200～1000	Riboflavin and derivant thereof (mg/kg)	????2～4
Sodium (mg/kg)	????200～1000	Potassium (mg/kg)	????100～300
Calcium (mg/kg)	????40～200	Potassium (mg/kg)	????100～300
Calcium (mg/kg)	????40～200	Magnesium (mg/kg)≤	????20～100
Ferrum (mg/kg)≤	????5～10	Magnesium (mg/kg)≤	????20～100
Ferrum (mg/kg)≤	????5～10	Zinc (mg/kg)≤	????5～10

Food additive: the food additive of adding in the sports drink should meet the regulation of GB 2760, and wherein benzoic acid must not surpass 0.1g/kg, and saccharin sodium must not surpass 0.08g/kg, and cyclamate must not surpass 0.10g/kg.If use saccharin sodium and cyclamate simultaneously, the two total amount must not surpass 0.1g/kg.

The technical standard of now having only sports drink to have country to formulate in the drinks according to this standard, can exercise supervision to sports drink.Drink under the situation that this class beverage is not adapted at not having to move, because wherein contained sodium element can increase body burden, cause that cardiac load strengthens, hypertension, therefore, the crowd of hypertension should be noted that selection.And,, be convenient to absorption of human body and discharge because wherein contained vitamin is water miscible for some nutrients beverages, therefore can drink in right amount.

Along with China's WTO entry, the particularly development of food trade, seem very important of good rules environment, food-safety problem is subjected in the common concern, particularly time more than a year in the past of society.In April, 2003, SFDA---State Food and Drug Administration is set up in State Council's decision, and the function of giving SFDA is to coordinate the supervision of existing food safety, the investigation of supervision and the important cases of strengthening comprehension, drinks, food have now put the SFDA supervision under.

Though on China's relevant laws and regulations, have some clearly to stipulate, also do not have the new legislation of correlation function beverage to occur.Drinks is still waiting further research, for example also has a lot of incomplete places on the regulation of the tag identifier of drinks and functional component, technology.For functional composition, if determine the functional of it, a regular evaluation and relevant recognised standard must be arranged, no matter be from the world or domestic in China, must prove that all it is safe, this evolution for an industry is very important, and especially after industry had developed into to a certain degree, this problem was vital.

(2) basic demand of sports drink prescription

Different with common beverages, sports drink be according to when motion energy expenditure, organismic internal environment changes and cell function under the characteristics of physiology consumption during the degradation motion prepare, general design principles is for replenishing the nutritional labeling of losing and consuming when moving targetedly, play maintenance, improve motor capacity, the effect of allaying tiredness after the accelerated motion.At present, the basic demand to sports drink is:

1, certain sugared content

Sugar is extremely important to movement human.As you know, particularly in the prolonged exercise, sugar is most important as the fuel of motion in the motion.When storage sugared in muscle, liver and the blood was dewatered again simultaneously by a large amount of consumption, fatigue will take place: under cryogenic condition, rate of perspiration was low, and the amount lost of liquid is also little, and at this moment, replenishing of sugar just become key; But under hot and wet environment, losing of perspiration receives publicity, and stores before the exhaustion because dehydration can occur in sugar.Athletes etc. are limited except coming to prepare also often to need at the volley to replenish sugar enough sugar deposits for motion by containing sugared meals because the human organism stores the amount of sugar.

The proportioning of liquid and sugar in the sports drink: gyp sports drink designs for replenishing sugar and liquid rapidly to body.Its prescription is divided into usually: hypotonic, etc. blend height and ooze three kinds.The sugar (Saccharum Sinensis Roxb. and polymerization sugar) that three's the main distinction is to be dissolved in the beverage is different with the amount of salt (sodium and potassium), and the big more osmotic pressure of concentration is high more.The sports drink of different osmotic enters the speed difference of blood.Hypotonic and wait the sports drink ooze (osmotic pressure that promptly is lower than and equals blood of human body) be under the thermal environment, prolonged exercise or a large amount of movement human designs of perspiring, it is more paid attention to water, sugar and salt and enters blood fast; Height oozes sports drink (osmotic pressure that promptly is higher than blood of human body) mainly in order to the deposit of sugar to be provided, the stage of preparation before being used for moving and post exercise convalescent period more.

2, an amount of electrolyte

Kinetic perspiration causes electrolyte such as potassium, sodium to be lost in a large number, thereby causes that health is weak, even knots, and causes motor capacity to descend.And the sodium in the beverage, potassium not only help to replenish sodium, the potassium of losing in the perspiration, also help the stop of water in blood vessel, make body obtain more competent moisture.Too low as the electrolyte content in the fruit beverage, then do not have additional effect; Ruo Taigao then can increase the osmotic pressure of beverage, causes the gastrointestinal discomfort, and the moisture in the beverage can not be absorbed by body as early as possible.

3, Hyposmolality

The osmotic pressure scope of blood of human body is that 280～320 millis ooze equivalent/liter (mosmol/L), is equivalent to 0.9% sodium chloride solution or 5% glucose sugar juice.Make water in the beverage and other nutritional labeling as early as possible by stomach, and fully be absorbed, the osmotic pressure of beverage forces down than infiltration of plasma, promptly hypotonic beverage, and contained sugar and electrolytical kind and amount are the direct decision makers of beverage osmotic pressure in the beverage.Even nutritious sports drink contains multiple sugar, inorganic salt etc., still can keep Hyposmolality.

4, no carbonic acid gas, no caffeine, alcohol-free

Carbonic acid gas can cause the flatulence and the discomfort of stomach, if the too fast soda pop of drinking in a large number might cause symptoms such as stomach spasm even vomiting; Caffeine and ethanol have certain diuresis, the effect of dehydration, can further increase the weight of the loss of body fluid.In addition, the two also has stimulation to nervus centralis, is unfavorable for tired recovery.

Some sports drink with Specialty Design level also will consider other supplementary element of increase, as vitamin B group, can promote energy metabolism; Vitamin C then in order to remove free radical, reduces its injury to body, the generation of delay fatigue; An amount of taurine and inositol can promote proteinic synthesizing, and prevent proteinic decomposition, regulate metabolism, elimination that accelerates fatigue or the like.The difference of sports drink and other beverage sees Table 2, table 3:

The comparison of table 2, sports drink and other beverage

Beverage types	Sugar type	Sugar content	Electrolyte	Other nutrient	Osmotic pressure	Carbonic acid gas	Caffeine
Beverage types	Sugar type	Sugar content	Electrolyte	Other nutrient	Osmotic pressure	Carbonic acid gas	Caffeine	Soda pop	Sucrose	??≥10％	Trace	Do not have	High	Have	Do not have or have
Mineral water	Do not have	Do not have	Trace	Do not have	Extremely low	Do not have	Do not have	Soda pop	Sucrose	??≥10％	Trace	Do not have	High	Have	Do not have or have
Mineral water	Do not have	Do not have	Trace	Do not have	Extremely low	Do not have	Do not have	Fruit juice	Fruit juice or with sucrose	??≥10％	Unbalanced	Vitamin	High	Do not have	Do not have
Milk beverage	Lactose or with sucrose	??≥10％	Unbalanced	Vitamin	High	Do not have	Do not have	Fruit juice	Fruit juice or with sucrose	??≥10％	Unbalanced	Vitamin	High	Do not have	Do not have
Milk beverage	Lactose or with sucrose	??≥10％	Unbalanced	Vitamin	High	Do not have	Do not have	Tea beverage	Sucrose	??≥10％	Trace	Trace	High	Do not have	Have
Sports drink	Oligosaccharide, glucose taurine, inositol sucrose, fructose	??5～10％	In right amount	??V _B、V _C、	Low	Do not have	Do not have	Tea beverage	Sucrose	??≥10％	Trace	Trace	High	Do not have	Have

Table 3, four kinds of beverage main component investigation

The name of an article	Main component
The name of an article	Main component						Unified green tea	Pure water	White sugar	Green tea	Flos Jasmini Sambac	Vitamin C	Edible essence
The body drink	Pure water	White sugar	High fructose syrup	Citric acid	Flavorant	Sodium citrate	Unified green tea	Pure water	White sugar	Green tea	Flos Jasmini Sambac	Vitamin C	Edible essence
	Pure water	White sugar	High fructose syrup	Citric acid	Flavorant	Sodium citrate	Sodium chloride	L threonic acid	Emulsifying agent	Potassium chloride	Potassium sorbate	Magnesium chloride
	JIANLIBAO	Pure water	White sugar	Carbon dioxide	Mel	Citric acid	Sodium chloride	L threonic acid	Emulsifying agent	Potassium chloride	Potassium sorbate	Magnesium chloride	The carbon electrolyte
Natrium malicum		Pure water	White sugar	Carbon dioxide	Mel	Citric acid	Acesulfame potassium	Huang falls the moon	Edible essence				The carbon electrolyte
Natrium malicum		Red cattle	Pure water	White sugar	Taurine	Citric acid	Acesulfame potassium	Huang falls the moon	Edible essence			Lysine	Inositol
Caffeine	Sodium benzoate		Pure water	White sugar	Taurine	Citric acid	Vitamin	Essence	Citric acid	Carmine		Lysine	Inositol

Because sports drink has possessed above-mentioned primary condition, so it can in time keep the skin wet, keeps the body fluid normal equilibrium; Makeup energy is kept the stable of blood glucose rapidly; In time replenish inorganic salt, keep electrolyte and acid-base balance, improve the metabolism regulating power, improve thermoregulation and cardiovascular function etc.Therefore, the design principle of sports drink not only will be separated thirsty, and it is thirsty more will to disintegrate!

(3) using priciple of sports drink and method

All can produce heat in all physical exertions, the heat of being produced will be scattered and disappeared by the evaporation of perspiration.The perspiration amount lost has very big individual variation, and it depends on environmental condition, exercise intensity and distance.Be engaged in the people of motion in the past, supplementing water not usually, they think that moisturizing is harmful.But we know, even body fluid is in a small amount lost (body weight 2%), accuracy of action and motor skill in the time of also can damaging motion.Body fluid is lost greater than 5% of body weight, can influence thermoregulation and cardiovascular system, and can threat to life.But the harm of more common dehydration is to cause fatigue, thus the damage motor capacity.In order to prevent dehydration, the people that all take exercises will frequently drink water before, during and after motion, thereby keeps hydration status (so-called hydration is exactly inside and outside the body cell and in the blood an amount of moisture to be arranged all) in the overall process of motion.The intermission and the immediate postexercise of snack, motion and match before the meal early, between meal, the athlete can not take food, and the demand of energy is when very high, sports drink just can provide effective sugared source.

Body building also should be selected sports drink, because the proportioning of various compositions meets the actual needs of body for motion, so it can replenish body fluid, energy and the electrolyte of losing because of sweating rapidly, effectively keep even further improve human body at the volley or motion back state of living in.

Sports drink does not have problem to normal person and hypotensive, quotes sports drink after the hypertensive people motion and can make hypertension but suffer from.Because the hypertensive patient must limit Sal, contain the sodium that causes increased blood pressure in the Sal, it is higher that sports drink contains the sodium amount, and the blood pressure that certainly will make of hyperpietic's drink rises De Genggao.And the hyperpietic drinks sports drink at the volley indiscriminately, very easily brings out apoplexy.So, the unsuitable polydipsia sports drink of hyperpietic.

Sports drink is better than general soft drink.Soft drink is normally high that ooze, sodium deficiency, and this can make them at the gastric overstand, causes the stomach discomfort in the motion, also influences it in enteral absorption simultaneously.Many people select plain boiled water (what come the most generally now is mineral water) at the volley, and as the liquid complementary goods, particularly those do not need the people of endurance, and they do not need sugar, just can keep a suitable state.But in the time of the water fast Absorption, the lacking as can reduce whole capability and endurance of available sugar and sodium.A large amount of drinking-water are with dilute blood, and increase is urinated, and lower the further serious hope of drinking-water.

After having determined the kind of beverage, the time of drinking is also quite important.The people is when strenuous exercise, and heat production increases in the body, and perspiring becomes thermotaxic main path.Yet excessive sweating can cause dehydration, causes hypovolemia, has further reduced dermal blood flow, thereby causes that amount of sweat reduces, and the body heat-sinking capability descends, body temperature rise.When the people felt thirsty, health had been lost about 3% liquid of body weight.And the physiological function of human body and motor capacity at this moment all descends.Therefore, a lot of people just expect moisturizing when feeling thirsty, and this is incorrect.The way of science is all should note timely moisturizing before, during and after the motion.But sports drink can not guarantee the nutritive equilibrium of human body, and it can not substitute meals.

For the people, particularly athlete that participate in a large amount of physical exertions and the people who is engaged in body building, the wisest sports drink using method is:

1. whole day is intermittently drunk before, during and after the motion continually;

2. select the beverage liked, cold beverage is better to eat usually, and is convenient to the recovery of muscle power;

3. the beverage of Xuan Zeing will be satisfied the demand, and particularly will remember: if intravital sugar deposit does not lack, add excessive sugar less than helping in beverage;

4. guarantee a maximum before motion, but do not cause the beverage intake of stomach discomfort, the people mainly consumes the sugar of muscle the inside when motion, therefore, should allow its content reach than higher level before the motion.At this moment, preferably select the beverage that contains oligosaccharide for use.The metabolic characteristic of oligosaccharide is: it is unhappy to be absorbed into blood, does not influence motor capacity.

5. to earlier bring into use sports drink in the motion, not wait until and drink again when thirsty, because this moment, human body dewatered.

The principle of replenishing sports drink in the motion is: move and replenished 500 milliliters of liquid in preceding 2 hours, can increase muscle glycogen in the body, hepatic glycogen deposit and blood glucose source; Adopt a small amount of mode repeatedly in the motion,, replenished 125～250 milliliters of liquid in per 15～20 minutes, replenish blood glucose, prolong movement time, the generation of delay fatigue to prevent the discomfort of stomach; Motion back replenishes losing of liquid in the motion, whenever loses 1 kg body weight in the motion, and 1000 milliliters of fluid infusion can add the moisture that loses in the quick-recovery body, sugar, inorganic salt, trace element etc., promote that muscle glycogen recovers rapidly, reach the effect that banishes the feeling of languor.

6. the post exercise beverage should reach the purpose that helps antisecosis, and emphasis is to add nutritional labelings such as protein, aminoacid, and will supply the whole fluid losss in the motion, can judge the degree of hydration with the color of urinating, and it is light to reach urine.

7. will avoid drinking wine, tea, coffee and other contain the beverage of coffee, they can produce the side effect of diuresis and dehydration.If will celebrate the triumph of match in post-games, must confirm to drink again after fully rehydration has been closed;

8. do not having under the situation of rational meals, sports drink can not promote success.Effectively training and healthy diet and life style will make the used maximum effect of sports drink performance.

(4) electrolytical related content

The chemical compound that can conduct electricity under molten state or in aqueous solution is in electrolyte; All nonconducting chemical compound is in non-electrolyte under molten state or in aqueous solution.Electrolyte is in molten state or when water-soluble, can dissociate and come from ion by moving, from then on angle is classified, electrolyte can be divided into ion-type electrolyte and covalent type electrolyte two big classes: the ion-type electrolyte itself contains ion but can not move freely, in molten state or when being dissolved in water, be dissociated into the ion that moves freely; The covalent type electrolyte itself does not have ion, and when water-soluble, ionization is come from by the ion that moves under the effect of solvent molecule.

From mode classification widely, electrolyte divides strong electrolyte and weak electrolyte two classes: all or almost completely being ionized in aqueous solution moves freely ion, do not have chemical compound that molecule exists strong electrolyte, promptly by ionic bond, have the chemical compound that chemical bond such as strong polar covalent bond forms; Every in aqueous solution part be ionized into ion for moving freely, also have chemical compound that unionized molecule exists weak electrolyte, promptly have the chemical compound that chemical bond such as polar covalent bond forms by some.

Described strong electrolyte comprises ionic compound and polar compound etc., for example strong acid, highly basic and most salt, and strong acid comprises H ₂SO ₄, HCL, HNO ₃, HCLO ₄, HI etc., highly basic comprises NaOH, KOH, Ba (OH) ₂Deng, most salts comprise BaSO ₄Wait this class difficulty soluble salt.

Described weak electrolyte comprises the covalent compound of polar bond etc., for example weak acid, weak base, water and minority salt, and weak acid comprises CH ₃COOH, H ₂CO ₃, H ₂S, HF etc., weak base comprises NH ₃H ₂O, Al (OH) ₃Deng, the minority salt comprises (CH ₃COO) ₂Pb etc.

(5) progress of sports drink

The high level motor capacity keep and one of principal element that sports fatigue produces is exactly sugared supply.In order to improve in the body deposit of sugar, improve the supply of sugar in the motion, various nutrition measures such as glycogen filling technique, to contain sugared sports drink etc. be the important content of sport nutrition research always.Oligosaccharide is the micromolecular compound of 3～8 glucose polymerisations of a class, and under the condition that the equivalent glucose is provided, osmotic pressure on average only is 1/4 of a glucose.Lower osmotic pressure helps the fast Absorption of water, with replenishing of water in the assurance motion.The oligosaccharide infiltration rate is obviously faster than starch; Can quickly supplement energy at the volley, but be slower than single, double sugar, avoid once a large amount of insulin responses that back blood glucose sharply raises and causes that absorb.

The BeiJing medicine University Sports Medicine Insitute has carried out serial clinical research to the oligosaccharide sports drink in nutrition Biochemical Research chamber, and result of study shows: oligosaccharide is used for moving and mends the intake that sugar can improve sugar, improves the kinergety supply.A kind of effect of drinking that contains the oligosaccharide beverage of 20% sugar and an amount of inorganic salt is observed in human experimentation, and 3 group objects (N=8) are drunk oligosaccharide beverage, sucrose solution, contrast liquid respectively, and intensity is to pedal to tired.The result shows: oligosaccharide beverage can make blood glucose maintain higher level, but and stabilised blood capacity, serum insulin, blood magnesium, blood potassium and blood lactic acid, increase motion acting and time.

Because oligosaccharide still had advantages such as Hyposmolality and low sugariness at its sugar-containing concentration up to 20% o'clock, also mainly formed simultaneously by 3 monosaccharide owing to oligosaccharide, it is slower than monosaccharide and disaccharidase that it decomposes infiltration rate, therefore for the effect that is supplied with uniqueness that prolongs sugar in the endurance exercise.Glycogen levels can become deciding key factor in little, the energy supply efficient height of oxygen consumption during glycosyloxy, body when endurance exercise is competed.

The external special benefits of using oligosaccharide beverage aspect saving human body muscle glycogen consume in long-time, improving endurance, has obtained significant effect.Institute of Microorganism, Academia Sinica is by lot of experiments, and Preliminary development goes out the oligosaccharide based on 38 sugar.With this sugar is base material, has added a spot of complex inorganic salt catalyst etc., through debugging, has made the oligosaccharide sports drink.Reasonable sports drink is generally selected based on oligosaccharide, the Oligomeric maltose that is combined by 3～10 monosaccharide has distinctive feature, its infiltration is forced down, sugariness is low, mouthfeel good, insulin response is low, help replenishing blood glucose, make brain and muscle when motion, constantly absorb sugar, can make the blood glucose of human body in prolonged exercise keep higher level, do not cause that blood concentrates or serum insulin concentration increases, thereby help prolonging the endurance time, reinforcement and acting amount, the recovery after delay fatigue and the accelerated motion.Up-to-date result of study shows that oligosaccharide beverage also helps and reduces blood lactate level in the motion, increases muscle strength and acting amount.In addition, the sugar in the sports drink improves the effect of mouthfeel, stimulation beverage intake, raising beverage absorbance in addition.But China is domestic because of producing employed " enzyme " in oligosaccharide process reason of aspect such as do not pass a test, and does not apply in large area as yet so far.

Aspect the sports drink prescription, report that U.S. scientist develops a kind of being applicable to recently and is engaged in the sports drink that fierce active athlete reaches work personnel fast Absorption under hot condition.This beverage is the energy with sucrose, and calcium, magnesium, potassium ion are electrolyte, and be all soluble in water.The benefit that adopts sucrose is to need to be hydrolyzed to glucose in the digestive tract and fructose is absorbed by the body again, and being released energy has dauer effect.Potassium ion is the most desirable with potassium chloride, and every liter of solution should contain 9.2～11.8 millinormal potassium chloride, and the calcium molecule is best with calcium gluconate, and every liter of solution should contain 1.8～2.6 millinormal calcium gluconate.For well, every premium on currency solution should contain 0.2～0.7 milliequivalent to magnesium ion with magnesium chloride.This beverage also helps to prevent effects such as spasm that the harmonization of the stomach foot produces and prevention lose weight.

Along with new product is constantly released, to pursue under the promotion of consuming behavior easily at one, energy drink and sports drink continued to keep increasing fast in soft beverage in 2003.Though most growth comes from North America and Asia, it has occupied the share in energy drink and sports drink market 80%, the U.S. and Japan remain maximum market at present, but energy drink and sports drink are just popular rapidly and extensive universal in Eastern Europe and West Europe, and European countries catch up with and surpass.Show that according to Canadian statistical report West Europe energy drink in 2003 and sports drink market approximately are 1,005 ten thousand liters, and the consumption figure in Eastern Europe approximately is 7,600 ten thousand liters; This report says that also lower than West Europe if not high price and Eastern Europe income level because of import brand, growth rate perhaps can be faster.。

Though the beverage of these exploitations at present and sale can the part relieving fatigue, because the difference of the theory and practice aspect human-body fatigue research is not seen the report that quick alleviation is arranged and remove the product aspect of fatigue, stamina intensifying now as yet.

Summary of the invention

The technical problem that will solve required for the present invention is to disclose a kind of composition and method of making the same and purposes that is used for alleviating and removing fast fatigue, stamina intensifying, to overcome the above-mentioned defective that prior art exists.

(1) technical conceive of the present invention

1, core viewpoint of the present invention is: human body is in strenuous exercise such as exercise, training or sports tournament, and the work under work in hot environment such as the indoor high temperature of the workman of steel plant, work under railway, the open-air high temperature of highway construction personnel, after reaching during training under the open-air high temperature of army personnel or the operation etc., serious disorder takes place the cylinder electrolyte level is to cause one of acute fatigue most important reason.Be embodied in: a large amount of lactic acid produce in the human body, and blood plasma pH value descends, and redistribution in the body, blood plasma radical ion generation etc. are lost or taken place to multiple inorganic ions and trace element.And in time adjust the blood plasma electrolyte level, and correct disorder, then can regain one's strength fast, solve the acute fatigue problem.

And present drinks sports drink particularly, generally fail to consider the outstanding feature of electrolyte disturbance in such cases comprehensively, this prescription just is being based on result of study and the relevant document of inventor to middle-distance runner's aerobic and anaerobic exercise, the back electrolyte disturbance is regulated targetedly to moving, and suitably increase trace element and/or nutrient substance in the case of necessary again, thereby can reach the human physical power fast quick-recovery, reduce the exercise fatigue degree, increase the good result of endurance.

2, main theoretical basis of the reform of Chinese economic structure of the present invention is: in time additional an amount of electrolyte etc. helps stable and adjustment movement person's etc. organism balance, helps quick allaying tiredness, delay fatigue generation.

According to existing measurement data, the osmotic pressure scope of human body is at 280～320mosmol/L, and serum pH is 7.35～7.45, and serum N a concentration is at 136～145mmol/L, and serum K concentration is at 3.5～5.5mmol/L, and fasting glucose concentration is at 3.9～6.1mmol/L.In sports or the powerful work, body water, perspiration Loss Rate are about 1～2L/h, Na, K and sugared content are respectively 1.08g/L, 0.036g/L, 0.070g/L in the perspiration, and athlete or body-building personnel drink water speed usually at 600～1000ml/h in the motion, therefore, in the strenuous exercise or afterwards cylinder electrolyte is lost in a large number or is redistributed, and osmotic pressure changes thereupon.If can make the human body osmotic pressure keep or quickly recover in normal range, alkaline reserve in the serum pH is kept or fast quick-recovery in normal range, serum N a, serum K and other electrolyte and trace element concentration also can keep or fast quick-recovery in normal range, so just can alleviate or remove human-body fatigue fast.In addition, trace element such as copper, zinc, manganese are by playing a role to tens of kinds of enzymes that influence human body physiological function, and the human body fatigue alleviating is had important function; Especially an amount of copper, the zinc element of rational Application in proportion in the motion or after the motion helps alleviating fast and removing tired more.

So we the more important thing is the ratio of considering each component in the constituent of research composite formula, key problem is the cooperative effect between each component.Have only each component is made up according to certain ratio, can reach the suitable prescription of above-mentioned requirements, can realize the purpose of quick alleviation, relieving fatigue and stamina intensifying.When being necessary, timely more additional suitable nutritional labeling can also be when alleviating and removing fatigue fast, the endurance of increase motion.

3, the documents and materials of foundation of the present invention are:

(1) collaborative equilibrium problem: the absorption of ferrum can strengthen because of copper, vitamin C and various composite B vitamin (influence ferrum absorption, transport and the synthesizing of cytochrome system and hemoglobin), zinc-vitamin A and copper can increase it and absorb, and supplementation with copper can prevent the consumption (copper of human body 95% with Ceruloplasmin combine) of zinc in body stores.

(2) alkaline reserve in the blood is mainly adjusted by taking in bicarbonate or analog, for example:

Sodium bicarbonate: the alkaline reserve that can mend sodium and supplement consumed; Replenish a certain amount of sodium, not only can replenish sodium, can also stimulate and drink, keep moisture, guarantee the supply of water in the motion.

Potassium bicarbonate: can kalium replenishment and the alkaline reserve (especially for anaerobic exercise) of supplement consumed; During athlete's potassium deficiency, utilizing of sugar is limited.

(3) effect of other common components of sports drink

1. sugared: as to be most economical, the most direct main energy sources material of human body.It is stored in skeletal muscle and liver with the form of glycogen.Because intravital sugar deposit is limited, as not having to replenish because of consuming in a large number, muscle will be weak when motion, and motor capacity also descends thereupon.On the other hand because of the energy supply of brain more than 90% from blood glucose, the decline of blood glucose will make brain that the regulating power of motion is weakened, and produces feeling of fatigue.Therefore must contain the effect that a certain amount of sugar just can reach makeup energy in the sports drink of scientific formula.And fructose effective than the synthetic hepatic glycogen of glucose, more help the recovery of post exercise energy substance.

2. copper: be a kind of essential nutrients, copper can not be stored in human body, must replenish every day.Copper and zinc all are essential trace element in the human body.Protection cell and the not oxidated damage of cell membrane, keep connective tissue and blood vessel integrity, generate skin and hair pigment, produce neurotransmitter and other hormones and comprise the biosynthesis of haemachrome and discharge from the key position of liver sausage aspect the iron metabolism of ferrum, all play an important role; Constitute multiple enzymes such as superoxide dismutase (tackling the murder by poisoning of superoxide ion), lysyloxidase (keeping the elasticity of tissue and the normal function of connective tissue), cytochrome oxidase, dopamine.

When lacking copper, cause injuries such as leukopenia, anemia, neural demyelination, decalcification of bone, large artery trunks fragility increase easily.Suggestion magnitude of recruitment every day (RDA) that the test of balance of copper is made is about 1.5～2.0mg.

3. zinc: found that at present 100 plurality of enzymes must have zinc, wherein the overwhelming majority is those and NAD ⁺Or NADP ⁺Enzymatic activitys such as various dehydrogenase types that link to each other and lactic acid dehydrogenase, zinc supplement can influence the LDH activity, the generation and the decomposition of lactic acid when regulating strenuous exercise.The RAD of the zinc about 15mg (serum copper/zinc is between 0.9～1.2) that grows up.Zinc can combine with mercaptan, reduces the peroxidization that ferrum brings out, and reduces the generation of free radical, suppresses biomembranous lipid peroxidation, the 26S Proteasome Structure and Function of stabilising membrane.

4. manganese: be the component and the activator of plurality of enzymes, can be used as the component of arginase, pyruvate carboxylase etc., can the activating phosphatase enzyme, Isocitrate dehydrogenase, participate in the cellular energy metabolism.After supplementation with copper, the manganese, metabolic function that can enhancing body, the appearance of delay fatigue.

5. selenium: be the essential composition of oxygen radical removing enzyme (glutathione peroxidase etc.) in the body, Cu, Zn, Mn still are the essential composition of mitochondrion SOD, directly disproportionation oxygen-derived free radicals.

6. vitamin C (V _C): be a kind of good antioxidants, can with vitamin E (V _E) coupling plays and strengthen V _EThe effect of protecting film lipid.In addition, V _CBe famous anti-fatigue active material, can improve myocardial function, reduce the oxygen debt in the motion.

7. taurine: a kind of essential amino acids (2-aminoethyl sulfonic acid) that is human body, can quicken the removing speed of body free radical, have tangible lipoid peroxidization resistant, it can reduce the generation of lipid peroxide MDA (malonaldehyde), the stabilate film is safeguarded the inside and outside ionic equilibrium of cell; Improve the vigor of GSH-Px (glutathion reductase) in the body, effectively block the generation of lipid peroxidation; Can improve the body aerobic capacity, improve myocyte's coefficient of oxygen utilization, thereby improve the body movement ability.

(4) influence the factor that the absorption of human body sports drink becomes component velocity

The amount of 1. drinking; 2. the speed of gastric emptying; 3. at the speed of little intestinal absorption.Hypotonic beverage contains sugared few, and the concentration of sol particle is lower than blood, and it provides liquid fast, and emptying and absorption still can not provide the sugar of q.s soon from stomach; Contain sugar 5～8% Deng oozing beverage, sol particle wherein is identical with blood, can promptly absorb, and may be that the best that satisfies liquid and sugared needs is simultaneously selected product for use; Height oozes in the beverage content of sol particle and is higher than blood (mainly being sugar), uses when needing extra energy, and the emptying from stomach of this beverage is slow, will absorb moisture to dilute before little intestinal absorption from blood, is unfavorable for that fast rehydrating closes.

(5) effect of electrolyte supplement

The liquid that exists in the human body is called body fluid.The people is the individuality of a dynamic equilibrium, is in dynamic equilibrium between each position body fluid, and water and electrolyte in it also are in dynamic equilibrium.Organic/inorganic substance and Organic substance in the body fluid, inorganic matter and part are commonly referred to as electrolyte with the Organic substance that ionic species exists.Therefore and disequilibrium after perspiring during the people strenuous exercise, electrolyte is often lost along with losing of moisture, and the intravital electrolyte of people; In case the body fluid of human body is unbalance, the regulating power of body, endurance etc. also will decrease.

The situation of body fluid, electrolyte and acid base imbalance appears in body system, is can come by the electrolyte oral liquid of suitable dosage the little chemistry of human body is adjusted and stable; If can note replenishing some electrolyte beverages, just can prevent water, electrolyte disturbance in the body preferably, play and replenish the human body nutrient rapidly, effectively regulate the equilibrated effect of body fluid.If but keeping the skin wet merely, things turn out contrary to one's wishes in meeting, both do not reached the purpose of moisturizing, even can cause fervescence, the generation of " water intoxication " symptoms such as Calf muscle spasm.

(2) design of components of the present composition and prescription

The design of components of the present composition requires: the prescription requirement of design can reach and help keeping or recover the multinomial physiological and biochemical index of human body within normal range, the osmotic pressure scope of promptly controlling human body is at 280～320mosmol/L, serum pH is 7.35～7.45, serum N a concentration is at 136～145mmol/L, serum K concentration is at 3.5～5.5mmol/L, and blood sugar concentration is at 3.9～6.1mmol/L; Satisfy athlete in the motion or body-building personnel simultaneously and drink water speed usually in the requirement of 600～1000ml/h, because body water, perspiration Loss Rate are about 1～2L/h in sports or the powerful work, Na, K and sugared content generally are respectively 1.08g/L, 0.036g/L, 0.070g/L in the perspiration.

Athlete or body-building personnel's motion every day amount of drinking water apparent motion intensity size is determined, usually at 4～10 liters/day; And their water requirement for each person every day is basic water requirement (3.3～3.6 liters) and motion amount of drinking water sum.In the time of component design, need to consider this demand.

That is to say that in the constituent of research composite formula, the more important thing is the ratio of considering each component, key problem is the cooperative effect between each component.Have only each component is made up according to certain ratio, can design the suitable prescription that reaches above-mentioned requirements, can realize alleviating fast and removing tired purpose.And when being necessary, timely more additional suitable nutritional labeling can also be when alleviating and removing fatigue fast, the endurance of increase motion.

Described composite formula designing requirement can reach and help keeping or recover the multinomial physiological and biochemical index of human body within normal range, and preferred scheme is to make this prescription be made into every index behind the liquid beverage within the normal range of the multinomial physiological and biochemical index of human body.

Therefore, the component of the present composition comprises: electrolyte, trace element and nutrient; Its w/v is respectively 1.0～3.5g/L, 2.4～10.0mg/L, 40～120g/L, preferred 1.5～2.8g/L, 5.0～10.0mg/L, 40～60g/L, further preferred 2.0g/L, 8.0mg/L, 41.2g/L.

Described electrolyte is to comprise in strong electrolyte and the weak electrolyte etc. one or more, preferred strong electrolyte;

Wherein, described strong electrolyte is to comprise in ionic compound and the polar compound etc. one or more, for example strong acid, highly basic and most salt, preferred salt; Described strong acid comprises H ₂SO ₄, HCL, HNO ₃, HCLO ₄, among the HI etc. one or more, described highly basic comprises one or more among NaOH, the KOH etc., described salt is to comprise in carbonate or the halid alkaline metal salt etc. one or more; Described carbonate is to comprise sodium bicarbonate (NaHCO ₃), potassium bicarbonate (KHCO ₃) in waiting one or more, described halid alkaline metal salt comprises sodium chloride (NaCL), potassium chloride (KCL), potassium iodide (KI) or calcium chloride (CaCL ₂) in waiting one or more; Further preferred sodium bicarbonate, potassium bicarbonate and sodium chloride;

Described weak electrolyte comprises one or more in the covalent compound of polar bond etc., for example weak acid, weak base, water and minority salt, further preferred weak acid; Described weak acid is to comprise CH ₃COOH, H ₂CO ₃, H ₂Among S, the HF etc. one or more, described weak base comprises NH ₃H ₂O, Al (OH) ₃Deng in one or more, described salt comprises (CH ₃COO) ₂Among the Mn etc. one or more, further preferred again H ₂CO ₃

Described trace element is to comprise in selenium, copper, zinc, manganese or the magnesium etc. one or more, one or more of preferably copper, zinc or magnesium, further one or more of preferably copper or zinc; When selecting to add copper, zinc simultaneously, the ratio of its Copper in Serum, zinc (Cu/Zn) should be in range of normal value (0.9～1.2).

Described nutrient is to comprise in the materials such as saccharide, vitamins, amino acids or other nutrients one or more; Described glucide is to comprise glucose, fructose, polysaccharide or 1, one or more in the 6-fructose diphosphate etc.; Described vitamin substances is to comprise in vitamin A, vitamin B, vitamin C or the vitamin E etc. one or more; Described amino acids material is to comprise in taurine or the branched-chain amino acid (comprising leucine, isoleucine, valine etc.) etc. one or more; Described other nutrients are to comprise in Chinese medicine tonic such as Radix Ginseng, Radix Codonopsis, Herb Gynostemmae Pentaphylli or Fructus Schisandrae Chinensis or the conditioning medicine one or more; Preferred glucose, fructose, polysaccharide, 1, one or more in 6-fructose diphosphate, vitamin C, vitamin E, taurine or the Radix Ginseng etc., one or more in further preferred glucose, fructose or the taurine etc.

(3) preparation method of the present composition

One of method is: according to prescription, electrolyte, trace element, nutrient are dissolved in an amount of water, promptly can get one of needed target product.

Two of method is: according to the process for preparing medicine of routine, electrolyte, trace element, nutrient are prepared into relevant dosage forms such as tablet, oral liquid or injection, can access needed purpose equally, promptly two of target product.

(4) purposes of the present composition

Therefore compositions of the present invention can be used in preparation beverage corresponding or food owing to can alleviate and alleviate human-body fatigue fast, improve endurance, as liquid or solid sports drink, motion food etc.; Simultaneously, said composition also is suitable for preparing particularly severe electrolyte patient's medicine of treatment human electrolyte disorder.So, compositions of the present invention can satisfy in human body strenuous exercise, the strong physical work or strenuous exercise, strong physical work after needs, and the needs of the electrolyte disturbance patient's that causes of some dehydration first aid etc.; Be particularly suitable in athlete or the body-building personnel motion or post exercise fluid infusion needs.For example, said composition is made into tablet according to the requirement of medicine preparation, can either uses, also be convenient to carry and use to the athlete who goes away to patient, or the carrying and using of out on tours personnel, or the disaster relief team member personnel etc. that use as fight flood and relieve victims; The requirement that said composition is prepared according to medicine is made into preparations such as injection or oral liquid, can use to patient equally.

Described strenuous exercise comprises violent physical exertion, training or sports tournament; Described strong physical work comprises work in hot environment, as the work under the indoor high temperature of the workman of steel plant, work under railway, the open-air high temperature of highway construction personnel, training or operation under the open-air high temperature of army personnel, building under the summer high temperature or decoration worker's work, the high strength consumption of some situation of out on tours personnel is as rock-climbing expedition, action such as part rescue and relief work.

(5) advantage of the present invention

Trace element such as copper, zinc is the cofactor of tens of kinds of important enzymes in the body, and the present invention adds trace element such as an amount of copper, zinc, helps the activity of tens of kinds of required important enzymes of fast quick-recovery body movement, helps giving full play to body potential.Present sports drink and general beverage, the adding of trace element such as all strict limit copper, zinc is not seen to have in the general beverage and is specially added copper.The present invention is according to the relevant result of study of inventor: after athlete's high pressure training, copper is lost the characteristics of (about 30%) significantly, in the composite formula of design, add heavy dose of trace element such as copper, be up to 5mg/L, and the while is according to the range of normal value adding zinc element of the ratio (Cu/Zn) 0.9～1.2 of copper, zinc.This dosage is according to theory vision of the present invention, and the auxilliary card of corresponding experimental data is in the scope of safety, and to setting up fast is very effective, big quantum jump the constraint of existing theory and product, therefore adding trace element such as heavy dose of copper, zinc in the present composition prescription, is of the present invention one big characteristic.

Carbonate (comprising sodium bicarbonate, potassium bicarbonate etc.) in the present composition prescription can be removed the lactic acid that produces behind the body movement fast, and replenishes losing of potassium due to the motion and part sodium element simultaneously.Bicarbonate be in the body body fluid in the environment maximum buffering be the key component of blood in human body in liquid caustic soda deposit to anion, add bicarbonate and can strengthen the buffer capacity of internal milieu greatly, and can remove lactic acid, the H that the motion back produces in the body ⁺Deng to the influential material of homeostasis, blood pH was maintained in normal range, thereby the maintenance human internal environment's is relatively stable.

Suitably replenish nutrients such as glucose, fructose, can replenish the needs of muscle glycogen fast, also guaranteed the synthetic of hepatic glycogen.Liver and muscle are respectively the main histoorgans of storing hepatic glycogen, muscle glycogen, but the physiological significance of hepatic glycogen, muscle glycogen has a great difference, be that hepatic glycogen is the important source of blood glucose, muscle glycogen mainly is the needs of energy when supplying flesh to shrink, and fructose has the anabolic effect that promotes hepatic glycogen, glucose that the synthetic effect of the muscle glycogen of promotion is then arranged; During body movement, at first consume muscle glycogen,, progressively consume hepatic glycogen along with momental increase, final if untimely supply sugar can cause hypoglycemia, even shock.Therefore, the energy demand that flesh shrank when additional glucose can directly satisfy motion, supplemental fructose then can increase the deposit of blood glucose by increasing the synthetic of hepatic glycogen, the energy demand that flesh shrinks in the time of also can directly satisfying motion after the release, thereby the quick muscle fatigue of alleviating when moving.

Branched-chain amino acid (comprising leucine, isoleucine, valine etc.) helps to participate in protein synthesis, still important decomposition energy supply material.Add branched-chain amino acid, help fatigue alleviating, thereby improve sports achievement.

The result that the present invention detects in the achievement and the practice thereof of motion theory research according to the inventor, the prescription of design team's compound targetedly, composition, content range safety is appropriate, the formula proportion scientific and effective, main difference is to increase several important trace element compositions, and rationally control mutual ratio between each component, take into account each other, one-object-many-purposes is brought into play the biological effect of compositions to greatest extent, therefore generation that can delaying human body fatigue, and can alleviate and alleviate human-body fatigue fast, regain one's strength stamina intensifying, be fit to multiple industry and use, have the wide development using value.

Main feature of the present invention is: in the design of composition components, according to the collaborative balance between each composition, consider every possible angle, can reduce lactic acid fast, and replenish the electrolyte of losing, important trace element or other compositions, the collaborative balance that performance is best.

In a word, the reasonable supplement of electrolyte and trace element, and the composite supply of nutrient such as compound saccharide are the basic assurances of quick adjustment electrolyte balance; The adding in proportion of trace element then is to ensure that organism metabolism balance institute is essential.The sharpest edges of prescription are aggregate balancing, quick adjustment.

The specific embodiment

The present invention has improved some design defect in the existing sports drink composition, one of purpose is to provide a kind of and can delaying human body tiredly takes place, alleviates fast and lessen fatigue, regains one's strength, the compositions of stamina intensifying, two of purpose is to provide the preparation method of said composition, three of purpose is to provide the purposes of this product, so that the application of aspects such as people's scientific research, motion, the disaster relief, tourism, medical treatment.

Prescription of the present invention needs comprehensive considering various effects when design, be configured in proportion, otherwise do not reach expected effect, even toxicity may occur.For example, the following potassium drink formula that contains is: sodium chloride 3.5 grams, potassium chloride 1.5 grams, sodium bicarbonate 2.5 grams, glucose 20 grams, and with taking behind the eliminating cold for resuscitation water dissolution.This prescription is an acceptable if be used for severe potassium deficiency personnel's (as hypokalemia) disposable taking targetedly; But, if just easily go wrong, because the content of its potassium up to 791mg/L, is nearly 8 times of (Headquarters of the customary amount of potassium in the sports drink prescription as general sports drink, Departments of Army, Navy and Air Force.Prevention, Treatmentand Control of Heat Injury.TB Med 507, Navmed P-5052-5, AFP 160-1,1980), this kind prescription only suits to do medicinal, and should not be used as conventional beverage; Drink the beverage of this prescription for a long time or in a large number, cause potassium intoxication (as hyperkalemia) easily, human body is damaged.

Compositions of the present invention can be used separately, also can use with many chemical substances, these chemical substances biologically active or have the function of treatment disease whether no matter, these chemical substances are to comprise a kind of in pharmaceutically acceptable carrier, food, natural product, chemical synthetic drug or the human medication etc.; Preferably include a kind of in pharmaceutically acceptable carrier or the food etc.; Further preferred pharmaceutically acceptable carrier.

Said carrier comprises excipient, as starch, water etc.; Lubricant is as magnesium stearate etc.; Disintegrating agent is as microcrystalline Cellulose etc.; Filler is as lactose etc.; Bonding agent is as pregelatinized Starch, dextrin etc.

Compositions of the present invention can be used in the preparation of fatigue alleviating product, as sports drink, buccal sheet etc., can enter human body by various approach such as oral or veins as food or medicine; Promptly can adopt technical field known method such as beverage, food, medicine to make various oral liquids, solid food, pharmaceutical dosage form etc., as common beverage, tablet, capsule, granule, suspensoid, Emulsion, solution, syrup, injection etc., take oral or approach such as injection (comprising intravenous injection, intravenous drip, intramuscular injection, subcutaneous injection), mucosa dialysis replenish.

Preparation for beverage, food or medicinal liquid preparation such as solution, solution, suspensoid, Emulsion, syrup, gel, ointment, injection etc., selected dressing comprises that any dressing commonly used such as cyclodextrin compound, ethylene glycol, propylene glycol, tween, ethanol, wet goods all can select for use being lower than to produce under the stimulating dose, can also add suitable acid or alkali and buffer solution such as citric acid and phosphate buffer to guarantee the stability of chemical substance; For guaranteeing the isotonicity matter of liquid preparation, can also select for use to add sodium chloride, mannitol, glucose etc., also can add antiseptic in addition.

For the preparation of beverage, food or medicinal solid preparation such as tablet, capsule, pill, injectable powder, granule, suppository etc., selected dressing comprises that cyclodextrin compound and any solid carrier commonly used all can select for use.

In the above-described type of service, preferred drink, tablet and pill, further preferred liquid beverage, tablet, preferred liquid beverage especially.

The product that is used for fatigue alleviating of preparation of compositions of the present invention can be used in according to the product of the requirement of beverage, food technology field preparation wherein that post exercise is tired to be alleviated; Can be used in patient's treatment or health care according to the product of the requirement of medical technical field preparation, can either be directly used in the medicine of preparation treatment or health care separately, also can mix with many chemical substances or make up, directly or indirectly be used to prepare the medicine of treatment or health care.Chemical substance described here is above described identical with this section; When being used for the patient, the dosage of compositions of the present invention is 40～1750mg/kgd, and this dosage or consumption normally decide according to age, body weight and health or patient's symptom of user.

In the present invention, required material comprises each component of compositions of the present invention, above-mentioned chemical substance, matching used water etc., all should adopt the material of food stage or pharmaceutical grade according to practical situation and needs.

Compositions of the present invention can either be used as beverage especially sports drink, no matter is liquid or solid state; Also can use separately or with the unclassified stores food prepared therefrom, also can use in some cases certainly as medicine.

In the present invention, the example of the following stated is in order to set forth the present invention better, is not to be used for limiting scope of invention.

Embodiment 1, a kind of complex function type composite formula of fatigue alleviating and preparation method thereof fast that is used for after the large amount of exercise

(1) prescription of this compositions helps keeping or recovers the designing requirement of the multinomial physiological and biochemical index of human body within normal range and design according to reaching, the osmotic pressure scope of promptly controlling human body is at 280～320mosmol/L, serum pH is 7.35～7.45, serum N a concentration is at 136～145mmol/L, serum K concentration is at 3.5～5.5mmol/L, and blood sugar concentration is at 3.9～6.1mmol/L; Athlete or body-building personnel drink water speed usually in the requirement of 600～1000ml/h in the satisfied simultaneously motion, and the concrete component and the content thereof of one of them prescription are as follows:

Chinese molecular formula concentration osmotic pressure

1. sodium bicarbonate NaHCO ₃1.00g/L (11.9mmol/L) 23.8mosmol/L

2. potassium chloride KCL 0.48g/L (6.5mmol/L) 13.0mosmol/L

3. sodium chloride NaCL 1.02g/L (17.5mmol/L) 35.0mosmol/L

4. glucose C ₆H ₁₂O ₆40g/L (222.2mmol/L) 222.2mosmol/L

5. copper chloride CuCL ₂10.5mg/L (0.078mmol/L) 0.234mosmol/L

6. zinc sulfate ZnSO ₄7H ₂O 22.0mg/L (0.076mmol/L) 0.152mosmol/L

7. branched-chain amino acid 3g/L (23mmol/L) 23.0mosmol/L

Branched-chain amino acid described in this prescription is to comprise in leucine, isoleucine or the valine etc. one or more.

Drinking-water speed when this prescription can reach existing anthropometric data scope and human body large amount of exercise designs, and promptly osmotic pressure is about 320mosmol/L, Na concentration 0.675g/L (29.34mmol/L), K concentration 0.25g/L (6.39mmol/L), alkaline reserve at 0.73g/L, total sugar content 4%, copper content 5mg/L, zinc content 5mg/L.

(2) preparation method: with each component of above-mentioned composition, be dissolved in the 1000ml drinking water, promptly get sports drink;

(3) losing topmost electrolyte ingredient in the motion is potassium, sodium etc., adds NaHCO in the prescription ₃, compositions such as KCL, NaCL, both guaranteed enough alkaline reserves, take into account the stable content of potassium, sodium again, keep Na simultaneously ⁺, CL ^-Balance makes CL ^-Content is unlikely too high;

In component design constituent, be to use alkaline reserve, trace element and nutritional supplementation simultaneously on the one hand, be to use an amount of copper, zinc element on the other hand, and reached the requirement in the design at each component ratio of prescription.

(4) the present invention is applicable to the athlete of hard training, mainly is in time to correct blood plasma pH after the large amount of exercise and replenish sugar, potassium, sodium and copper, zinc.

Embodiment 2, a kind of complex function type composite formula of fatigue alleviating and preparation method thereof fast that is used for after the field work

Chinese molecular formula concentration osmotic pressure

1. sodium bicarbonate NaHCO ₃0.69g/L (8.2mmol/L) 16.4mosmol/L

2. potassium chloride KCL 0.47g/L (6.4mmol/L) 12.8mosmol/L

3. sodium chloride NaCL 2.0g/L (34.5mmol/L) 69.0mosmol/L

4. glucose C ₆H ₁₂O ₆20g/L (111.1mmol/L) 111.1mosmol/L

5. fructose C ₆H ₁₂O ₆20g/L (111.1mmol/L) 111.1mosmol/L

6. copper chloride CuCL ₂2.5mg/L (0.019mmol/L) 0.057mosmol/L

7. zinc sulfate ZnSO ₄7H ₂O 5.28mg/L (0.018mmol/L) 0.036mosmol/L

Drinking-water speed when this prescription can reach existing anthropometric data scope and human body large amount of exercise designs, and is that osmotic pressure is about 320mosmol/L, Na concentration 0.981g/L (42.65mmol/L), K concentration 0.25g/L (6.39mmol/L), alkaline reserve at 0.50g/L, total sugar content 4%, copper content 1.2mg/L, zinc content 1.2mg/L.

(4) the present invention is applicable to many crowds that perspires, or the timely needs of correcting blood plasma pH and replenishing potassium, sodium etc. after successive high strength or the high temperature field work.

(5) be the effect of further this prescription, strengthen human tolerance, can in this prescription, add Radix Ginseng extract such as ginsenoside 10～50mg/L, or in the sports drink that is mixed with, directly add Radix Ginseng decoction pieces 100～300mg/L; Also can add other similar health food or medicines, as Radix Codonopsis, Radix Pseudostellariae etc.

Embodiment 3, a kind of complex function type composition and method of making the same of fatigue alleviating fast that is used for after continuously training or the contest

Chinese molecular formula concentration osmotic pressure

1. sodium bicarbonate NaHCO ₃1.0g/L (11.9mmol/L) 23.8mosmol/L

2. potassium chloride KCL 0.22g/L (3.0mmol/L) 6.0mosmol/L

3. sodium chloride NaCL 0.8g/L (13.7mmol/L) 27.4mosmol/L

4. glucose C ₆H ₁₂O ₆20g/L (111.1mmol/L) 111.1mosmol/L

5. 1,6-fructose diphosphate C ₆H ₁₀O ₆(PO ₄) ₂40g/L (118.0mmol/L) 118.0mosmol/L

6. copper chloride CuCL ₂8.4mg/L (0.062mmol/L) 0.19mosmol/L

7. zinc sulfate ZnSO ₄7H ₂O 17.6mg/L (0.061mmol/L) 0.12mosmol/L

8. taurine C ₂H ₇O ₃SN 1.2g/L (9.6mmol/L) 9.6mosmol/L

Drinking-water speed when this prescription can reach existing anthropometric data scope and human body large amount of exercise designs, and promptly osmotic pressure is about 290mosmol/L, Na concentration 0.59g/L (25.65mmol/L), K concentration 0.12g/L (3.07mmol/L), alkaline reserve at 0.73g/L, total sugar content 4.1%, copper content 4mg/L, zinc content 4mg/L.

(3) 1 in the composite formula of the present invention, the 6-fructose diphosphate is a kind of fructose that contains energy-rich phosphate bond, after the use, hepatic glycogen not only can be provided, and can provide ATP (Adenosine Triphosphate, adenosine triphosphate) synthesize required phosphoric acid and energy, and ATP is one of muscular energy source;

Add essential amino acids such as taurine and be very important, experimental results show that an amount of supplementation of taurine before and after the motion, can delay fatigue, help improving sports achievement;

Losing topmost electrolyte ingredient in the motion is potassium, sodium etc., adds NaHCO in the prescription ₃, compositions such as KCL, NaCL, both guaranteed enough alkaline reserves, take into account the stable content of potassium, sodium again, keep Na simultaneously ⁺, CL ^-Balance makes CL ^-Content is unlikely too high;

(4) the present invention is applicable to the athlete of continuous training or contest.

Embodiment 4, the present invention are used for the prescription and its production and use of the athletic compositions of general training

Chinese molecular formula concentration osmotic pressure

1. sodium bicarbonate NaHCO ₃0.5g/L (5.95mmol/L) 11.9mosmol/L

2. potassium chloride KCL 0.22g/L (3.0mmol/L) 6.0mosmol/L

3. sodium chloride NaCL 1.2g/L (20.5mmol/L) 41.1mosmol/L

4. glucose C ₆H ₁₂O ₆20g/L (111.1mmol/L) 111.1mosmol/L

5. fructose C ₆H ₁₂O ₆20g/L (111.1mmol/L) 111.1mosmol/L

6. copper chloride CuCL ₂2.5mg/L (0.019mmol/L) 0.056mosmol/L

7. zinc sulfate ZnSO ₄7H ₂O 5.28mg/L (0.018mmol/L) 0.037mosmol/L

Drinking-water speed when this prescription can reach existing anthropometric data scope and human body large amount of exercise designs, promptly osmotic pressure be about 280mosmol/L, pH 7.35, Na concentration 0.61g/L (26.52mmol/L), K concentration 0.12g/L (3.07mmol/L), alkaline reserve be at 0.36g/L, total sugar content 4.0%, copper content 1.2mg/L, zinc content 1.2mg/L.

(3) composite formula of the present invention, in component design constituent, be to use alkaline reserve, trace element and nutritional supplementation simultaneously on the one hand, be to use an amount of copper, zinc element on the other hand, and reached the requirement in the design at each component ratio of prescription.

(4) the present invention is applicable to the athlete of normal training, the motion or the work in hot environment of moderate strength.

Embodiment 5, the present invention are used to be convenient to prescription of the compositions of going out to carry and its production and use

(1) prescription of this compositions helps keeping or recovers the designing requirement of the multinomial physiological and biochemical index of human body within normal range and design according to reaching, the osmotic pressure scope of promptly controlling human body is at 280～320mosmol/L, serum pH is 7.35～7.45, serum N a concentration is at 136～145mmol/L, serum K concentration is at 3.5～5.5mmol/L, and blood sugar concentration is at 3.9～6.1mmol/L; Satisfy athlete in the motion or body-building personnel simultaneously and drink water speed usually in the requirement of 600～1000ml/h, it is as follows that one of them prepares the concrete component and the content thereof of prescription of 1000 tablet preparations:

1. sodium bicarbonate (NaHCO ₃) 625g

2. potassium chloride (KCL) 330g

3. sodium chloride (NaCL) 1600g

4. glucose (C ₆H ₁₂O ₆) 25000g

5. copper chloride (CuCL ₂) 3.16g

6. zinc sulfate (ZnSO ₄7H ₂O) 6.61g

7. taurine (C ₂H ₇O ₃SN) 1500g

(2) preparation method: press the method for preparing tablet thereof of field of medicaments, said composition is made into tablet, can drink according to the ratio of every 1000～2000ml water during use.For example, the preparation method of tablet:

Prescription:

Sodium bicarbonate 625g

Potassium chloride 330g

Sodium chloride 1600g

Glucose 25000g

Copper chloride 3.16g

Zinc sulfate 6.61g

Taurine 1500g

Starch 30g

Lactose 40g

Carboxymethyl starch sodium 5g

Starch slurry (7%) is an amount of

Magnesium stearate 1.25g

Make 1000

Technology:

Get each component of compositions of recipe quantity, pulverized 100 mesh sieves, again starch, the lactose of recipe quantity were pulverized 100 mesh sieves, mixing.Each component of compositions, carboxymethyl starch sodium are added in the starch and lactose of mixing mixing.Add an amount of 7% starch slurry and mix thoroughly, granulate through 16 order ferrum silk screen nets, dry below 60 ℃, granulate adds an amount of magnesium stearate mixing, tabletting behind the analysis content.Can be made into 1000 every tablet tablet that contains the 70mg compositions.

This prescription can also be made by the injection preparation method of field of medicaments, is used for patient's medical treatment.

(4) the present invention becomes tablet with preparation of compositions, be easy to carry, be specially adapted to disaster relief team member and use, as the personnel etc. that fight flood and relieve victims, or athlete's use of going abroad and participating in training or match, or high-intensity country sport comprises uses such as tourism or high temperature field work.Using method is to drink after being dissolved in tablet in the water in proportion, or drinks an amount of water in proportion behind the oral tablet.

(5) the present invention is with the tablet of preparation of compositions, and use amount generally is no more than 4 for each person every day.

Claims

1. a compositions that is used for fatigue alleviating is characterized in that, the component of said composition comprises electrolyte, trace element and nutrient, and its w/v is respectively 1.0～3.5g/L, 2.4～10.0mg/L, 40～120g/L; And the designing requirement of component can help keeping or recover the multinomial physiological and biochemical index of human body within normal range, satisfies the common requirement at 600～1000ml/h of drinking-water in the motion simultaneously.

2. the compositions that is used for fatigue alleviating according to claim 1, it is characterized in that, the design of components of described compositions requires can help keeping or recover the multinomial physiological and biochemical index of human body within normal range, is to make this prescription be made into every index behind the liquid beverage within the normal range of the multinomial physiological and biochemical index of human body.

3. the compositions that is used for fatigue alleviating according to claim 1 and 2 is characterized in that, the w/v of component electrolyte, trace element and the nutrient of described compositions is respectively 1.5～2.8g/L, 5.0～10.0mg/L, 40～60g/L.

4. the compositions that is used for fatigue alleviating according to claim 3 is characterized in that, the w/v of component electrolyte, trace element and the nutrient of described compositions is respectively 2.0g/L, 8.0mg/L, 41.2g/L.

5. the compositions that is used for fatigue alleviating according to claim 1 and 2 is characterized in that, described electrolyte is to comprise in strong electrolyte or the weak electrolyte one or more.

6. the compositions that is used for fatigue alleviating according to claim 5 is characterized in that, described strong electrolyte is to comprise in ionic compound or the polar compound one or more.

7. the compositions that is used for fatigue alleviating according to claim 6 is characterized in that described strong electrolyte is a salt, is to comprise one or more of carbonate or halid alkali metal salt apoplexy due to endogenous wind.

8. the compositions that is used for fatigue alleviating according to claim 7, it is characterized in that, described carbonate is to comprise in sodium bicarbonate or the potassium bicarbonate one or more, and described halid alkaline metal salt is to comprise in sodium chloride, potassium chloride, potassium iodide or the calcium chloride one or more.

9. the compositions that is used for fatigue alleviating according to claim 5 is characterized in that, described weak electrolyte is to comprise in the covalent compound of polar bond one or more.

10. the compositions that is used for fatigue alleviating according to claim 9 is characterized in that, described weak electrolyte is to comprise one or more of weak acid, weak base, water or minority salt.

11. the compositions that is used for fatigue alleviating according to claim 1 and 2 is characterized in that, described trace element is to comprise in selenium, copper, zinc, manganese or the magnesium one or more.

12. the compositions that is used for fatigue alleviating according to claim 11 is characterized in that, described trace element is to comprise in copper, zinc or the magnesium one or more, and when selecting copper, zinc simultaneously, the ratio of its copper, zinc is in range of normal value.

13. the compositions that is used for fatigue alleviating according to claim 1 and 2 is characterized in that, described nutrient is to comprise in glucide, vitamin substances, amino acids material or other nutrients one or more.

14. the compositions that is used for fatigue alleviating according to claim 13 is characterized in that, described glucide is to comprise glucose, fructose, polysaccharide or 1, one or more in the 6-fructose diphosphate; Described vitamin substances is to comprise in vitamin A, vitamin B, vitamin C or the vitamin E one or more; Described amino acids material is to comprise in taurine or the branched-chain amino acid one or more; Described other nutrients are to comprise in the medicine one or more of Chinese medicine tonic or conditioning.

15. the compositions that is used for fatigue alleviating according to claim 13 is characterized in that, described nutrient is to comprise glucose, fructose, polysaccharide, 1, one or more in 6-fructose diphosphate, vitamin C, vitamin E, taurine or the Radix Ginseng.

16. the compositions that is used for fatigue alleviating according to claim 3, it is characterized in that the component of described compositions comprises sodium bicarbonate 1.00g/L, potassium chloride 0.48g/L, sodium chloride 1.02g/L, glucose 40g/L, copper chloride 10.5mg/L, zinc sulfate 22.0mg/L, branched-chain amino acid 3g/L.

17. the compositions that is used for fatigue alleviating according to claim 3, it is characterized in that the component of described compositions comprises sodium bicarbonate 0.69g/L, potassium chloride 0.47g/L, sodium chloride 2.0g/L, glucose 20g/L, fructose 20g/L, copper chloride 2.5mg/L, zinc sulfate 5.28mg/L.

18. the compositions that is used for fatigue alleviating according to claim 3; it is characterized in that; the component of described compositions comprises sodium bicarbonate 1.0g/L, potassium chloride 0.22g/L, sodium chloride 0.8g/L, glucose 20g/L, 1,6-fructose diphosphate 40g/L, copper chloride 8.4mg/L, zinc sulfate 17.6mg/L, taurine 1.2g/L.

19. the compositions that is used for fatigue alleviating according to claim 3, it is characterized in that the component of described compositions comprises sodium bicarbonate 0.5g/L, potassium chloride 0.22g/L, sodium chloride 1.2g/L, glucose 20g/L, fructose 20g/L, copper chloride 2.5mg/L, zinc sulfate 5.28mg/L.

20. the compositions that is used for fatigue alleviating according to claim 1 and 2, it is characterized in that, the step of the preparation method of described said composition is: according to prescription, electrolyte, trace element, nutrient are dissolved in an amount of water, promptly get needed target product.

21. the compositions that is used for fatigue alleviating according to claim 1 and 2, it is characterized in that, the step of the preparation method of described said composition is: according to the process for preparing medicine of routine, electrolyte, trace element, nutrient are prepared into the relevant dosage form of tablet, oral liquid or injection, promptly get needed target product.

22. the application that is used for the compositions of fatigue alleviating at the preparation sports drink according to claim 1 and 2.

23. the compositions of fatigue alleviating that is used for according to claim 1 and 2 is in preparation motion Application in Food.

24. the application that is used for the compositions of fatigue alleviating at the medicine of preparation treatment electrolyte disturbance according to claim 1 and 2.