CN1615903A - Virus medicine for silk worm - Google Patents
Virus medicine for silk worm Download PDFInfo
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- CN1615903A CN1615903A CN 200310105645 CN200310105645A CN1615903A CN 1615903 A CN1615903 A CN 1615903A CN 200310105645 CN200310105645 CN 200310105645 CN 200310105645 A CN200310105645 A CN 200310105645A CN 1615903 A CN1615903 A CN 1615903A
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- silkworm
- virus
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Abstract
The compound viral disease preventing and treating medicine preparation for silk worm consists of erythromycin thiocyanate as main medicine component and chlorine dioxide powder as auxiliary medicine component in the weight ratio of 1 to 3-10, preferably 1 to 4-6 and packed separately. When the medicine preparation is used, chlorine dioxide powder is first dissolved, erythromycin thiocyanate is then added for mixing homogeneously, water in 500 times is added and the medicine liquid is sprayed to mulberry leaf fed to silk worm to prevent and treat viral disease.
Description
Affiliated technical field:
The present invention relates to a kind of silkworm and use the diseases prevention medicament, especially a kind of silkworm is with preventing and treating viral agent.
Background technology:
China's Bombyxmori Linnaeus area is very wide, and viral diseases such as the nucleopolyhedrosis of silkworm body and cytoplasmic polyhedrosis are a great problems that the puzzlement silkworm is already developed, and also the medicament of not finding really to prevent and to treat silkworm precursor virus disease at present.
Summary of the invention:
The purpose of this invention is to provide a kind of new and effective composite drug that can prevent and treat silkworm precursor virus disease.
The present invention is achieved in that it is a kind of composite drug, is combined by host and two kinds of medicaments of secondary agent, and host is sulfur hydracid erythromycin, and secondary agent is the chlorine dioxide powder, and its weight proportion is 1: 3-10, best preferred version are 1: 4-6.Described host and secondary agent all are city's pin industrial goods.Two kinds of medicaments are packed respectively, during use, with the dissolving of chlorine dioxide powder, pour sulfur hydracid erythromycin then into earlier, add 500 times of water behind the mix homogeneously and stir, and are sprayed onto with aerosol apparatus and feed silkworm on the Folium Mori.
The beneficial effect that its invention brings is that two kinds of medicaments by the proportioning use antagonism do not take place, really reaches the purpose of the outer treatment by oral administration of medicines that disappears, and the incidence rate that reduces the silkworm virosis is had tangible effect, and Folium Mori are had preservation.Because of the main treatment of this invention silkworm precursor virus disease, so the name silkworm is controlled with virus.
One, effect experiment:
1, to the prevention effect of nucleopolyhedrosis: the prophylactic tria district once adds food " virus is controlled " in the whole every month phase of the length of service, play silkworm in 3 ages then and once manually add food caryogram polyhedral body variable concentrations, treatment region rose after silkworm once manually adds food silkworm caryogram polyhedral body variable concentrations in 3 ages, once add food " virus is controlled " whole 3 length of times, in 3 age Mos investigation sickness rate, and reinvestigate once age, the results are shown in following table:
| The trial zone | Sickness rate (%) under the different virus concentration (x/ml) | ??ID 50 | Average attack rate | Protection effect | |||
| ????10 7 | ????10 6 | ????10 5 | ????10 4 | ||||
| Pre-defence area | ????65.0 | ????50.0 | ????30.0 | ????22.5 | ??5.54 | ?41.875 | ????44.49 |
| Treatment region | ????50.0 | ????30.0 | ????17.5 | ????5.0 | ??6.54 | ?25.625 | ????66.12 |
| The check plot | ????100.0 | ????97.5 | ????62.5 | ????42.5 | ??4.49 | ?75.625 | |
Annotate: ID
50Calculate expression by cumulative method and make for examination silkworm 50% virus concentration when sick;
Sickness rate summation/concentration the number of times of average attack rate (%)=variable concentrations;
Protection effect (%)=(check plot sickness rate-trial zone sickness rate)/contrast sickness rate
Table 1 data show: " virus is controlled " has excellent prevention and therapeutical effect to bombyx nuclear polyhedrosis, and especially the better effects if of treatment region is in pre-defence area.
2, to the prevention effect of cytoplasmic polyhedrosis:
To play silkworm artificial vaccination virus, the therapeutic modality that is administered once every day then 3 ages.Studied the polyhedrosis therapeutic effect of " virus is controlled " confrontation type:
| The trial zone | The different following sickness rate of sick concentration (%) | Average attack rate (%) | Protection effect (%) | The average protection effect in medication district | ||||
| ????10 7 | ????10 6 | ????10 5 | ????10 4 | |||||
| The medication district | ????1 | ????/ | ????15.0 | ????10.0 | ????0.0 | ??8.33 | ????72.23 | ????69.45 |
| ????2 | ????/ | ????17.5 | ????12.5 | ????0.0 | ??10.00 | ????66.66 | ||
| The check plot | ????/ | ????50.0 | ????30.0 | ????10.0 | ??30.00 | ????/ | ????/ | |
" virus is controlled " not only has tangible prevention effect to the nucleopolyhedrosis that takes place in the blood as can be seen from the above table, and the matter type polyhedral body that takes place in the intestines and stomach is also had tangible prevention effect, and better effects if reaches about 70%.
Protection effect when 3, viral silkworm rearing bed being infected:
It is one of important way of virus disseminating that silkworm rearing bed infects, to the effective medicine of virus must be that silkworm rearing bed is infected the medicament that can play a role, this test has been infected matter type polyhedral body with a part and has been infected the silkworm of cytoplasmic polyhedrosis virus as the source of infection, since 2 age silkworm, sneak in the healthy silkworm by different proportion, then medication every day once, the sickness rate of 2 former healthy silkworms of " Invest, Then Investigate " in the length of time sees the following form:
| Subregion | Different blended is educated sickness rate under the ratio (%) | Average attack rate (%) | Protection effect (%) | |
| ????2.5％ | ????500％ | |||
| The medication district | ????7.5 | ????15.0 | ????13.33 | ????60.00 |
| The check plot | ????25.0 | ????37.5 | ????33.33 | ????/ |
Last table explanation " virus is controlled " can reach about 60.00% the infectious protection effect of silkworm rearing bed.
4, single agent is compared with the effect of multiple agent
| Medicine Liu composition | Sickness rate under the different virus concentration (%) | Average attack rate (%) | Protection effect (%) | ||
| ??10 6 | ????10 5 | ????10 4 | |||
| Single agent for oral administration | ??32.5 | ????17.5 | ????25 | ????17.50 | ????50.00 |
| Complexing agent | ??20.0 | ????12.5 | ????0.0 | ????10.83 | ????69.06 |
| Not medication contrast | ??60.0 | ????27.5 | ????17.5 | ????35.0 | ????/ |
Annotate: medication one is " virus is controlled " of instant preparation, and medication two is " virus is controlled " of preparation before the one and a half months;
Two, Physiological Experiment:
Being 600 since 3 ages is 1 district, and the medication district is in 3 first feeding in age each medication 1 time when just sleeping, and to putting on an arrow, the check plot is with waterleaf substituted drug liquid since 4 medications in every month age 1 time, and cocoon output is produced in investigation and cocoon quality sees the following form:
| Investigation content | The check plot | The medication district | Medication district and check plot are relatively | |
| For an examination silkworm number (head) | ????600 | ????600 | Identical | |
| Output | Total amount of cocoon production | ????821 | ????861 | ????+40 |
| A number of always cocooing | ????578 | ????580 | ????+2 | |
| Cocoon quality | Kilogram cocoon grain number | ????704 | ????674 | ????-30 |
| 100 Bombyx bombycis total amounts | ????147 | ????149.5 | ????+2.5 | |
| 100 cocoon qualities (g) | ????37 | ????39 | ????+2.0 | |
| Cocoon layer rate (%) | ????25.17 | ????26.0 | ????+0.83 | |
| The dead silkworm number | 3 length of times | ????0 | ????0 | ????/ |
| 4 length of times | ????0 | ????0 | ????/ | |
| 5 length of times | ????0 | ????0 | ????/ | |
| Do not cocoon in putting on an arrow silkworm and dead silkworm head number | ????22 | ????20 | ????-2 | |
| The dead worm cocoon number | ????17 | ????14 | ????-3 | |
| Total number | ????39 | ????34 | ????-5 | |
Annotate: the mid-autumn experimental period silkworm
More than data clearly demonstrate in the table, every index in medication district is better than the check plot, proof " virus is controlled " has no effect to the physiology of silkworm, opposite because one of " virus is controlled " composition also has fresh-keeping function to Folium Mori, it is normal that the raising of the Folium Mori food value of leaf makes every index in medication district be better than the check plot.
Three, produce experiment:
Select 3 sericulture families, the each household silkworm seed is weighed to be divided into two, and educates separately raising with the chamber when collecting ants.The medication district 3 age first feeding with just sleep each medication 1 time, since 4 medications every day in age 1 time to the 4th day 5 ages till, waterleaf is added in the check plot when the medication district, medication with add water and all will be sprayed onto survey result such as following table with aerosol apparatus requirement Folium Mori positive and negative:
| Investigation content | The check plot | The medication district | Both relatively | |
| 3 families are for the total ant amount of silkworm (g) | ????20.625 | ????20.625 | Identical | |
| Output (summation) | Total amount of cocoon production (kg) | ????40.0 | ????42.4 | ????+2.4 |
| Total income (unit) | ????480.22 | ????516.54 | ????+36.32 | |
| Cocoon quality | Kilogram cocoon grain number | ????706 | ????706 | Identical |
| 100 cocoon total qualities (g) | ????141.6 | ????141.6 | Identical | |
| 100 cocoon qualities (g) | ????31.7 | ????31.9 | ????+0.2 | |
| Cocoon layer rate (%) | ????22.06 | ????22.19 | ????+0.06 | |
| Dead cage rate (%) | ????5.0 | ????4.0 | ????-1.0 | |
| The dead silkworm number | 3 length of times | ????0 | ????0 | |
| 4 length of times | ????65 | ????38 | ????-27 | |
| 5 length of times | ????30 | ????29 | ????-1 | |
| Do not cocoon in putting on an arrow silkworm and dead silkworm head number | ????113 | ????86 | ????-27 | |
| Total number | ????208 | ????153 | ????-55 | |
Annotate: experimental period is the mid-autumn: data are the average or summation number at 3 families in the table:
The analytical table result as can be seen, in raw cocoon production, add food " virus is controlled ", not only can reduce the Died Of Disease head number of silkworm, and can increase cocoon yield, improve cocoon quality and silkworm raiser's income, average every kind can improve (20g ant amount is equivalent to 36 yuan of 2 kind test value added incomes) about 18 yuan.
Four, stability experiment:
1, " virus is controlled " two kinds of compositions are mixed with water preparation after, respectively at that time with 1 month test effect relatively:
| Cause of disease | The trial zone | The sickness rate (%) that different virus concentration is following | Average attack rate (%) | Protection effect (%) | Medication relatively | |||
| ??10 7 | ??10 6 | ??10 5 | ????10 4 | |||||
| ?NPB | Medication one | ??25.00 | ??12.0 | ??0.0 | ????/ | ??12.33 | ??70.41 | |
| Medication two | ??27.5 | ??15.0 | ??2.5 | ????/ | ??15.00 | ??64.00 | ??91.42％ | |
| Contrast | ??62.5 | ??47.5 | ??15.0 | ????/ | ??41.67 | ??/ | ||
| ?CPB | Medication one | ??/ | ??15.0 | ??10.00 | ????2.5 | ??9.17 | ??72.35 | |
| Medication two | ??/ | ??17.5 | ??15.0 | ????2.5 | ??11.67 | ??64.82 | ??89.5％ | |
| Contrast | ??/ | ??42.5 | ??32.5 | ????20.0 | ??33.17 | ??/ | ||
The stability of powder
The work post composition of " virus is controlled " is powder, and according to the explanation on explanation on the pharmacopeia and the product book, two kinds of compositions did not lose efficacy in 1 year, is stabilized in more than 99.8%, places can keep drug effect more than 90% in 2 years.
Embodiment:
The present invention is further detailed explanation below in conjunction with implementing.
Embodiment 1: to control medicament with virus be example to prepare 100 grams silkworm of the present invention, gets sulfur hydracid erythromycin 10 grams, and chlorine dioxide powder 90 grams are packing respectively, is finished product.Now with the current during use by proportioning.
Embodiment 2: to control medicament with virus be example to prepare 100 grams silkworm of the present invention, gets sulfur hydracid erythromycin 16 grams, and chlorine dioxide powder 84 grams are packing respectively, is finished product.Now with the current during use by proportioning.
Embodiment 2: to control medicament with virus be example to prepare 100 grams silkworm of the present invention, gets sulfur hydracid erythromycin 15 grams, and chlorine dioxide powder 85 grams are packing respectively, is finished product.Now with the current during use by proportioning.
Claims (1)
1, a kind of silkworm is controlled medicament with virus, is primarily characterized in that by host and two kinds of medicaments of secondary agent to combine, and host is sulfur hydracid erythromycin, and secondary agent is the chlorine dioxide powder, and its weight proportion is 1: 3-10, best preferred version are 1: 4-6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310105645 CN1615903A (en) | 2003-11-12 | 2003-11-12 | Virus medicine for silk worm |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310105645 CN1615903A (en) | 2003-11-12 | 2003-11-12 | Virus medicine for silk worm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1615903A true CN1615903A (en) | 2005-05-18 |
Family
ID=34757361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310105645 Pending CN1615903A (en) | 2003-11-12 | 2003-11-12 | Virus medicine for silk worm |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1615903A (en) |
-
2003
- 2003-11-12 CN CN 200310105645 patent/CN1615903A/en active Pending
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