CN1613482A - Composition for improving memory and preparation thereof - Google Patents
Composition for improving memory and preparation thereof Download PDFInfo
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- CN1613482A CN1613482A CN 200310110894 CN200310110894A CN1613482A CN 1613482 A CN1613482 A CN 1613482A CN 200310110894 CN200310110894 CN 200310110894 CN 200310110894 A CN200310110894 A CN 200310110894A CN 1613482 A CN1613482 A CN 1613482A
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- radix astragali
- rhizoma anemarrhenae
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Abstract
A Chinese medicine for improving memory power and treating insomnia, neurasthenia, senile dementia, etc is prepared from astragalus root and anemarrhena rhizome through extracing their active compoents, proportionally mixing them with nervonic acid and shaping.
Description
[technical field]
The present invention relates to health care, field of medicaments, relate in particular to a kind of compositions, preparation method and the purposes in medical science thereof.
[background technology]
Hypomnesis is multifactorial, degenerates multiple situations such as children's's malnutrition as old people's brain aging.At present, mostly the health food that improves memory on the market is to be made up of fish oil (main component EPA, DHA), lecithin, aminoacid etc.Though above-mentioned each health food respectively has one's own knack technically, and has certain function of health care to some aspect of hypomnesis, on the whole, the following deficiency of ubiquity: 1, prevent that the effect of hypomnesis is not remarkable.2, just has certain function of health care, the improving memory DeGrain.3, prescription is more single, is difficult to have many-sided synergism, can not have simultaneously strengthen brain function, delay brain aging, improve the human body immunity, improve insomnia forgetfulness, neurasthenia, senile dementia symptom and improve intelligence effect.
[summary of the invention]
The object of the present invention is to provide a kind of new compositions, be used as the improving memory function, thereby improve the pharmaceutical composition of insomnia forgetfulness, neurasthenia, senile dementia symptom and raising intelligence.
Another object of the present invention provides a kind of preparation method of above-mentioned composition.
Realize the technical scheme of above-mentioned purpose:
A kind of compositions: form by Radix Astragali extract 40-120 weight portion and Rhizoma Anemarrhenae extract 30-90 weight portion.
Optimum ratio: 80 parts of Radix Astragali extracts, 60 parts of Rhizoma Anemarrhenae extracts.
Another kind of compositions: form by Radix Astragali extract 40-120 weight portion, Rhizoma Anemarrhenae extract 30-90 weight portion and nervonic acid 28-84 weight portion.
Optimum ratio: 80 parts of Radix Astragali extracts, 60 parts of Rhizoma Anemarrhenae extracts, 55 parts of nervonic acides.
Described preparation of compositions method comprises the steps:
1) preparation of Radix Astragali extract: get the Radix Astragali, add water boil, collect medicinal liquid,, concentrate through centrifugal decontamination, drying, promptly;
2) preparation of Rhizoma Anemarrhenae extract: get the Rhizoma Anemarrhenae, add edible ethanol, reflux, extract, is filtered, concentrates, and drying, promptly;
3) get Radix Astragali extract and Rhizoma Anemarrhenae extract by weight portion separately, mix homogeneously adds medically the acceptable adjuvant and makes solid or liquid dosage form.
Described another preparation of compositions method comprises the steps:
1) preparation of Radix Astragali extract: get the Radix Astragali, add water boil, taking liquid through centrifugal decontamination, concentrates to the greatest extent, drying, promptly;
2) preparation of Rhizoma Anemarrhenae extract: get the Rhizoma Anemarrhenae, add edible ethanol, reflux, extract, is filtered, concentrates, and drying, promptly;
3), get Radix Astragali extract, the step 2 of step 1) preparation by weight portion separately) Rhizoma Anemarrhenae extract and the nervonic acid of preparation, mix homogeneously adds medically the acceptable adjuvant and makes solid or liquid dosage form.
Adopt technique scheme, the technological progress that the present invention gives prominence to is: 1, metabolic process, the strong body constitution of Radix Astragali raising human body immunity, enhancing human body in the side, improve the adaptive capacity of body to internal and external environment, reduce the senile symptom of human body, the all right promoting flow of QI and blood of the Radix Astragali, blood viscosity lowering reduces the generation of cerebral infarction, and learning memory disorder is improved significantly.2, the Rhizoma Anemarrhenae can suppress cerebral atrophy, delays the naturally-aged process of brain, improves the ability of middle-aged and elderly people learning and memory.3, nervonic acid has the functions such as regeneration of improving the nervus centralis nutritional status, preventing the nervus centralis regression, strengthen brain tissue cell, and effects such as the memory of improvement and slow down aging are arranged.4, by its synergistic enhancing effect, drug effect has obtained improving greatly: shown in table 1-table 3, the Radix Astragali and the Rhizoma Anemarrhenae, nervonic acid are share, play jointly and strengthen brain function, delay brain aging, improve the human body immunity, reduce the effect that old common disease takes place, can effectively prevent insomnia forgetfulness, be short of physical strength, symptoms such as mental retardation, neurasthenia, senile dementia.Ability to the middle-aged and elderly people learning and memory improves significantly, and improves child, teen-age intelligence.
[specific embodiment]
The present invention can realize by following technology:
The preparation of embodiment one, raw material
1. the preparation of Radix Astragali extract
Get the Radix Astragali, add 6-14 and doubly measure purified water, boiled 1-3 hour, most taking liquid, medicinal residues add 4-8 again and doubly measure purified water, boil 1-2 hour, collect medicinal liquid, and extracted twice liquid merges, and centrifugal decontamination is concentrated into density 1.05-1.15, drying, promptly.
Preferably: get the Radix Astragali, add 10 times of amount purified water, boiled 2 hours, most taking liquid, medicinal residues add 6 times of amount purified water again, boil 1.5 hours, most taking liquid, extracted twice liquid merges, and the centrifugal decontamination of high speed tube centrifuge (20000r/min) is concentrated into 1/2 volume (density 1.09-1.11), spray drying (175 ℃ of air intakes, 90 ℃ of outlet temperatures, blast 0.5Mpa), promptly.
2. the preparation of Rhizoma Anemarrhenae extract
Get the Rhizoma Anemarrhenae, add 50%-85% edible ethanol 6-10 and doubly measured reflux, extract, 1-3 hour; Filter, medicinal residues add 50-85% edible ethanol 4-8 doubly to be measured reflux, extract, 1-2 hour, filtered, and merged filtrate twice, and being concentrated into does not have alcohol flavor (density 1.05-1.15), drying, promptly.
Preferably: get Rhizoma Anemarrhenae 10Kg, add 8 times of amounts of 80% edible ethanol reflux, extract, 2 hours; Filter, medicinal residues add 6 times of amounts of 80% edible ethanol reflux, extract, 1.5 hours, filter, and merge filtrate twice, and being evaporated to does not have alcohol flavor (density 1.09-1.11), spray drying (175 ℃ of air intakes, 90 ℃ of outlet temperatures, blast 0.5Mpa), promptly.
3. preparation of drug combination
Press the formula ratio raw material of Radix Astragali extract 40-120 weight portion, Rhizoma Anemarrhenae extract 30-90 weight portion, add adjuvant and make medical science acceptable solid, liquid dosage form.
Optimum ratio: 60 parts of 80 parts of Rhizoma Anemarrhenae extracts of Radix Astragali extract
The preparation of the capsule of embodiment two compositionss
Prescription: 60 parts of nervonic acid 56 weight portions of 82 parts of Rhizoma Anemarrhenae extracts of Radix Astragali extract
Extract each active component by the method for embodiment 1, mix with the recipe quantity proportioning, it is an amount of to add dextrin, mixing, in the glue shell of packing into promptly, every capsules 0.3g.
The preparation of the tablet of embodiment three compositionss
Prescription: 70 parts of nervonic acid 49 weight portions of 70 parts of Rhizoma Anemarrhenae extracts of Radix Astragali extract
Extract each active component by the method for embodiment 1, mix with the recipe quantity proportioning, with an amount of amylum pregelatinisatum mixing, one-step palletizing, the adding magnesium stearate is an amount of, and tabletting promptly gets tablet, the 0.3g/ sheet.
The granule preparation of embodiment four compositionss
Prescription: 40 parts of nervonic acid 45 weight portions of 100 parts of Rhizoma Anemarrhenae extracts of Radix Astragali extract extract each active component by the method for embodiment 1, mixes with the recipe quantity proportioning, and then with an amount of PVP mixing, one-step palletizing, packing is promptly.
The zoopery report
According to technique scheme, the capsule product (hereinafter to be referred as capsule) with preparation of pharmaceutical compositions of the present invention becomes has no side effect through the zoopery proof, and memory is had the improvement effect.
One: 30 day feeding trial of experimental example
One, test basis: GB15193.13-94 " toxicological evaluation of food safety procedure and method "
Two, assay and evaluation
WISTAR kind healthy rat is contained 0.50%, 1.00% and 2.00% capsule particle feedstuff every day, and dosage is 0.50,1.00,2.00g/kg.b.w, is equivalent to 25,50,100 times of human body recommended amounts, test period totally 30 days, and final result:
1. the general physiology sign of rat, behavior, defecation, fur etc. are all no abnormal.
2. body weight and food utilization index are normal.
3. the blood routine index is normal.
4. biochemical indicator is no abnormal.
5. each organ coefficient index is normal.
6. the inspection substantially of respectively organizing organs such as the rat heart, liver,spleen,kidney, small intestinal, testis is no abnormal; The liver of matched group and high dose group rat, kidney and the pathological observation result of small intestine are basic identical, do not see special pathological change.
Experimental example two: its mouse oral acute toxicity test (LD50), micronucleus test, sperm malformation test, Salmonella reversion test
One, test basis: GB15193.13-94 " toxicological evaluation of food safety procedure and method "
Two, assay and evaluation
1. its mouse oral acute toxicity test
Female, male mice per os LD50＞21.50g/kg.b.w are tried thing capsule of the present invention and are belonged to nontoxic level material.
2. mouse bone marrow cells micronucleus test
1.25 the micronucleus test result of～10.00g/kg.b.w dosage is negative, is tried thing capsule of the present invention somatic cell is not had mutagenesis.
3. mouse sperm deformity test
2.50 the spermatic aberration test result of～10.00g/kg.b.w dosage is negative, is tried thing capsule of the present invention sexual cell is not had mutagenesis.
4.Ames test
8～5000 μ g/ wares are tried thing mouse typhus Salmonella saltant TA97, TA98, TA1000, TA102 are carried out the plate infiltration test, no matter when adding and do not add the S9 mixed liquor, each dosage group does not cause that all the recovery mutation colony number of test strain significantly increases, the Salmonella reversion test result is negative, is tried thing capsule of the present invention and does not have direct or indirect mutagenic action.
Experimental example three: improve memory effect
One, test basis: " the health food function assessment assessment process and the method for inspection "
Two, assay and evaluation
Give capsule 0.1,0.2 of the present invention, 06g/kg.b.w totally 4 weeks respectively to Kunming mouse per os every day, successively adopt two batches of laboratory animal repeated trials, the result obtains:
1, at the mice diving tower with keep away in the dark experiment, capsule of the present invention obtains and maintains the improvement effect to the memory of mice passive avoidance response ability.
2, in the mice water maze laboratory, capsule of the present invention obtains and maintains the improvement effect to the memory of mice spatial discrimination.Judge that according to " the health food function assessment assessment process and the method for inspection " evaluation criterion capsule has the effect that improves mouse memory.
The human experiment laboratory report
To be added with nervonic acid and be prepared into the pharmaceutical composition of capsule product,, human body memory is had the improvement effect through human experiment:
1, materials and methods
1.1 sample copy invention capsule and used matched group Cebo-Caps provide by Shenzheng Taitan Medicine Industry Co., Ltd.
Capsule of the present invention is mainly prepared burden: Radix Astragali extract 40-120 weight portion, Rhizoma Anemarrhenae extract 30-90 weight portion, nervonic acid 28-84 weight portion.Optimum ratio: 80 parts of Radix Astragali extracts, 60 parts of Rhizoma Anemarrhenae extracts, 55 parts of nervonic acides.
The matched group Cebo-Caps: do not contain active ingredient in the test-meal product (nervonic acid, Rhizoma Anemarrhenae extract, Radix Astragali extract), its colourity, appearance packaging etc. are all identical with the test-meal product.
1.2 study subject is chosen 33-61 year healthy population, voluntary participation is divided into test-meal group and matched group at random, finishes the overall process test, obtains effective number 103 people altogether, and the test-meal group is 51 people, and matched group is 52 people.
1.3 experimental technique organizes the professional with double-blind method, detects the memory quotient (MQ) that test-meal group and matched group experimenter test front and back.
Each is taken by uniform requirement per capita 1.4 take method test-meal group and matched group, and every day, secondary, was taken 35 days altogether by each two.
1.5 statistical analysiss such as statistical method average check are used SPSS for Windows computer statistics software kit and are finished statistical analysis.
2, content measurement
Adopt the Gong Yao of Hunan Medical University wait earlier revision " revision Wechsler Memory Scale handbook is dissolved in before the test in every and each is surveyed once when finishing, and use the first formula before the test, uses the second formula after testing.Mainly comprise (1) long term memory test: personal story, about time and spatial orientation, numerical order relation; (2) short term memory test: picture is recalled, vision is re-recognized, vision regeneration, learning by association, understanding memory; (3) immediate memory test: along the back of the body and the back of the body numeral of falling.
2.1 picture is recalled (be called for short and recall)
The material of this a test comprises two cover pictures, and each 20 figure of every cover use for first, second two covers.Method is to allow the tester see that 20 Fig. 1 divide half earlier, takes away then, allows the tester recall.Each correct memory note 1 minute, mistake is recalled the back-off branch.
2.2 vision is re-recognized (abbreviation is re-recognized)
Divide first, second two cover memorize graph cards, 8 contents of every cover.Figure is arranged, word is arranged, also have symbol, allow the tester remember half a minute, take away then.Allow the tester have on the card of 28 contents and find out 8 things of having seen other one.(re-recognize the just the same note 2 minutes of content and memorize, re-recognize the similar note 1 minute of content and memorize, re-recognize the similar note 0 minute of content and memorize, re-recognized the irrelevant contents button 1 minute.The highest 16 minutes.)
2.3 vision regeneration (being called for short regeneration)
Two cover pictures, every cover each 3 cards, i.e. A, B, C.Wherein in A, B two cards figure is arranged respectively, C has two figure.Allow the tester see 10 seconds of A, B card earlier, after take away, allow the tester is silent on recorder chart to draw.The same quadrat method of C card.
2.4 learning by association (being called for short association)
Divide first, second two covers, use for the two cover tests of first, second.Every cover test has 10 pairs of speech to read to listen to the experimenter, is to the experimenter simultaneously and sees, each 2 seconds.Change second pair successively.10 pairs are over and stop reading in 5 seconds the last speech of every pair of speech again, the experimenter to say back one speech in 5 seconds.Wrong as the first pass answer, then to stop to carry out again second time after 10 seconds, method is identical, the order difference of speech; Wrong again, then stop to carry out after 10 seconds the 3rd time.Answered correct note in 5 seconds 1 minute.
2.5 understand memory (be called for short and understand)
Two cover stories are arranged, whenever be with first, second, the third three stories, first has 14 contents, and second has 20 contents, and third has 30 contents.Select second, the third two stories for use.The experimenter says story to the experimenter and listens, after promptly want the experimenter to repeat.Recall each content note 0.5 minute.Best result 25 minutes.
2.6 recite number (being called for short back of the body number)
(1) along the back of the body
First talk about the instruction, the experimenter understands, and is correct as first examination then from four figures, just read five-digit number, as mistake read second examination again with one digit number, answer as second examination wrong again, just stop this test.Reading number speed is per second one number.With correct suitable back of the body highest order number scale branch, best result 11 minutes.
(2) fall to carry on the back
First talk about the instruction, the experimenter understands, then falls to carry on the back since 3 figure places, and other are with suitable back of the body methods.
3, result
The test-meal group eats capsule of the present invention, and memory quotient (MQ) meansigma methods rises to 106.20 from 90.92 before and after the test-meal, on average raises 15.27; Placebo group memory quotient on average raises 8.73.This data is carried out statistical analysis (seeing Table 1), and the result shows: test-meal group and placebo group memory quotient average compare there was no significant difference (t=0.147＜t before the experiment
0.05 (101), p＞0.05), the experimenter that test-meal group and matched group are described is from same overall.Mean more all has highly significant difference (p＜0.01) before and after test-meal group and the matched group self, and prompting test itself has certain study effect, and two group objects may be because of being familiar with content measurement and method, and performance of the test all increases for the second time.But from two groups of mean comparative analysiss of testing forward and backward memory quotient, there was no significant difference before test-meal group and the matched group experiment, and experiment back memory quotient has highly significant difference (t=3.08＞t
0.01 (101), p＜0.01).Compare two group objects self front and back difference mean, the increasing value of test-meal group has highly significant difference (t=3.03＞t apparently higher than matched group
0.01 (101), p＜0.01), can get rid of the interference that matched group study effect causes, think that the raising of test-meal group memory quotient is apparently higher than matched group (seeing table 2 for details).Each scale score of test and significance test see Table 3 before and after the test-meal.Results suggest, capsule of the present invention has the improvement effect to the human body memory function.
Table 1 liang group objects MQ mean self paired comparison (x ± s)
After testing before the test of group example number
Test-meal group 51 90.92 ± 16.03 106.20 ± 9.43**
Matched group 52 90.50 ± 13.03 99.23 ± 13.16**
Annotate: * * represents p＜0.01
Compare between the MQ mean before and after the table 2 liang group objects test (x ± s)
Difference before and after the test back before the test
Test-meal group 90.92 ± 16.03 106.20 ± 9.43 15.27 ± 12.79
Matched group 90.50 ± 13.03 99.23 ± 13.16 8.73 ± 8.76
T value 0.15 3.08 3.03
P value p＞0.05 p＜0.01 p＜0.01
Each scale score of table 3 test of memory (x ± s)
Test-meal group (51 people)
Matched group (52 people)
After testing before the preceding test of the test back test
Along several 5.49 ± 3.42 8.00 ± 2.79** 5.77 ± 3.47 7.60 ± 3.19**
Reciprocal 10.08 ± 2.94 10.84 ± 2.29 9.90 ± 2.95 9.81 ± 3.14
Accumulation 10.35 ± 2.96 12.33 ± 1.45** 10.94 ± 2.67 11.21 ± 2.92
Picture 8.6 ± 2.25 10.00 ± 1.92** 8.33 ± 2.17 9.21 ± 1.82*
Re-recognize 8.96 ± 2.74 11.08 ± 2.36** 9.19 ± 2.71 11.06 ± 2.40**
Regeneration 9.31 ± 2.47 10.94 ± 1.94** 9.71 ± 1.86 11.37 ± 1.72**
Association 7.75 ± 3.53 8.59 ± 2.71 6.71 ± 3.56 7.37 ± 3.42
Sense of touch 8.93 ± 1.52 10.36 ± 1.14** 8.89 ± 1.48 9.76 ± 1.37
Understand 9.96 ± 2.34 12.20 ± 2.27** 9.60 ± 1.98 11.60 ± 2.21**
Carry on the back several 9.53 ± 2.36 9.73 ± 2.85 9.83 ± 2.01 8.63 ± 2.54**
Annotate: * represents p＜0.05; * represents p＜0.01
4, brief summary
The edible continuously capsule of the present invention of experimenter is after 35 days, and the memory quotient meansigma methods raises 15.27 than before edible, and front and back difference has highly significant (p＜0.01); With take placebo group memory quotient balanced growth value 8.73 relatively, the difference that test-meal group and matched group are two groups has highly significant (p＜0.01), the raising of test-meal group memory quotient is apparently higher than matched group.Therefore, capsule of the present invention has the improvement effect to human body memory.
Must be pointed out; above embodiment and experimental example; just illustrate of the present invention; they are intended to illustrate optimum implementation of the present invention; those skilled in the art is according to enlightenment of the present invention; in conjunction with the various changes that the general knowledge of this area is done, all will fall into the protection domain of claim of the present invention.
Claims (10)
1, a kind of compositions is characterized in that: be made up of Radix Astragali extract 40-120 weight portion and Rhizoma Anemarrhenae extract 30-90 weight portion.
2, compositions according to claim 1 is characterized in that: 80 parts of Radix Astragali extracts, 60 parts of Rhizoma Anemarrhenae extracts.
3, compositions according to claim 1 is characterized in that: also be added with nervonic acid 28-84 weight portion.
4, as compositions as described in the claim 2, it is characterized in that: also be added with 55 parts of nervonic acides.
5, a kind of pharmaceutical composition, contain the treatment effective dose as any described compositions among the claim 1-4.
6, as pharmaceutical composition as described in the claim 5, it is characterized in that: dosage form is medically acceptable solid or liquid preparation.
7, any described compositions is improved the medicine of memory and the application in the health food in preparation among the claim 1-4.
8, preparation of compositions method as claimed in claim 1 or 2 is characterized in that comprising the steps:
1) preparation of Radix Astragali extract: get the Radix Astragali, add water boil, collect medicinal liquid,, concentrate through centrifugal decontamination, drying, promptly;
2) preparation of Rhizoma Anemarrhenae extract: get the Rhizoma Anemarrhenae, add edible ethanol, reflux, extract, is filtered, concentrates, and drying, promptly;
3) get Radix Astragali extract and Rhizoma Anemarrhenae extract by weight portion separately, mix homogeneously adds medically the acceptable adjuvant and makes solid or liquid dosage form.
9, as preparation of compositions method as described in the claim 8, it is characterized in that:
1) preparation of Radix Astragali extract: get the Radix Astragali, add 6-14 and doubly measure purified water, boiled 1-3 hour, to the greatest extent taking liquid, medicinal residues add 4-8 again and doubly measure purified water, boiled 1-2 hour, and collected medicinal liquid, extracted twice liquid merges, the centrifugal decontamination of high speed tube centrifuge, be concentrated into density 1.05-1.15, spray drying, promptly;
2) preparation of Rhizoma Anemarrhenae extract: get the Rhizoma Anemarrhenae, add 50%-85% edible ethanol 6-10 and doubly measured reflux, extract, 1-3 hour; Filter, medicinal residues add 50-85% edible ethanol 4-8 doubly to be measured reflux, extract, 1-2 hour, filtered, and merged filtrate twice, and being evaporated to does not have the alcohol flavor, density 1.05-1.15, and spray drying, promptly.
10, as preparation of compositions method as described in claim 3 or 4, it is characterized in that comprising the steps:
1) preparation of Radix Astragali extract: get the Radix Astragali, add water boil, taking liquid through centrifugal decontamination, concentrates to the greatest extent, drying, promptly;
2) preparation of Rhizoma Anemarrhenae extract: get the Rhizoma Anemarrhenae, add edible ethanol, reflux, extract, is filtered, concentrates, and drying, promptly;
3), get Radix Astragali extract, the step 2 of step 1) preparation by weight portion separately) Rhizoma Anemarrhenae extract and the nervonic acid of preparation, mix homogeneously adds medically the acceptable adjuvant and makes solid or liquid dosage form.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310110894 CN1613482B (en) | 2003-11-04 | 2003-11-04 | Composition for improving memory |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310110894 CN1613482B (en) | 2003-11-04 | 2003-11-04 | Composition for improving memory |
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| CN1613482A true CN1613482A (en) | 2005-05-11 |
| CN1613482B CN1613482B (en) | 2010-09-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200310110894 Expired - Lifetime CN1613482B (en) | 2003-11-04 | 2003-11-04 | Composition for improving memory |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872276B (en) * | 2005-06-03 | 2010-04-28 | 天津天士力制药股份有限公司 | Application of medication composition of containing extractive of astragalus root in preparing medicine for treating insufficiency of blood supply for brain |
| CN104208368A (en) * | 2013-12-25 | 2014-12-17 | 上海诺金科生物科技有限公司 | Pharmaceutical composition for auxiliary improvement of memory and its preparation method and use |
| CN107594268A (en) * | 2017-08-04 | 2018-01-19 | 杨宇明 | A kind of invigorating brain and relieving mental uneasiness nervonic acid compound beverage antianxity and preparation method thereof |
| CN108721480A (en) * | 2018-07-03 | 2018-11-02 | 晨光生物科技集团邯郸有限公司 | A kind of compound Chinese medicinal preparation for treating a variety of insomnias |
| CN115737762A (en) * | 2022-12-14 | 2023-03-07 | 华夏先葆(北京)中药研究院有限公司 | A preparation composition with memory improving, brain health protecting and cognitive functions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1398529A (en) * | 2002-09-04 | 2003-02-26 | 杭州施惠泰食品化学有限公司 | Application of nervonic acid in breast milk-imitating milk powder for infant |
-
2003
- 2003-11-04 CN CN 200310110894 patent/CN1613482B/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872276B (en) * | 2005-06-03 | 2010-04-28 | 天津天士力制药股份有限公司 | Application of medication composition of containing extractive of astragalus root in preparing medicine for treating insufficiency of blood supply for brain |
| CN104208368A (en) * | 2013-12-25 | 2014-12-17 | 上海诺金科生物科技有限公司 | Pharmaceutical composition for auxiliary improvement of memory and its preparation method and use |
| CN107594268A (en) * | 2017-08-04 | 2018-01-19 | 杨宇明 | A kind of invigorating brain and relieving mental uneasiness nervonic acid compound beverage antianxity and preparation method thereof |
| CN108721480A (en) * | 2018-07-03 | 2018-11-02 | 晨光生物科技集团邯郸有限公司 | A kind of compound Chinese medicinal preparation for treating a variety of insomnias |
| CN115737762A (en) * | 2022-12-14 | 2023-03-07 | 华夏先葆(北京)中药研究院有限公司 | A preparation composition with memory improving, brain health protecting and cognitive functions |
| CN115737762B (en) * | 2022-12-14 | 2024-02-02 | 华夏先葆(北京)中药研究院有限公司 | A pharmaceutical composition with memory improving and brain health and cognitive function protecting effects |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1613482B (en) | 2010-09-08 |
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