CN1607387A - Method and apparatus for improving blood measurement reliability using multi-channel circuit - Google Patents
Method and apparatus for improving blood measurement reliability using multi-channel circuit Download PDFInfo
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- CN1607387A CN1607387A CN 200310101256 CN200310101256A CN1607387A CN 1607387 A CN1607387 A CN 1607387A CN 200310101256 CN200310101256 CN 200310101256 CN 200310101256 A CN200310101256 A CN 200310101256A CN 1607387 A CN1607387 A CN 1607387A
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Abstract
This invention provides a method for using a multi-channel circuit to increase blood measurement reliability including: sampling blood to drip a drop of blood on an electrode part of a biosensor which provides a voltage to test the blood after a preset time, then getting test values for different channels to carry out digital process to get the digital test values for different channels to be output to a micro-control unit comparing the difference of the digital test values and an approved value to decide if the drop of blood is enough, finally, the micro-control unit processes the digital test values of different channels to get a mean test value and process the result based on the mean value.
Description
Technical field
The present invention relates to a kind of multi-channel circuit that uses and promote method and device that blood measures fiduciary level, the particularly whether enough and method and the device that the measuring value of different channel circuits are averaged processing relevant for a kind of amount of using multi-channel circuit to judge to gather blood of bleeding.
Background technology
Because the progress of modern medicine science and technology makes human mean lifetime constantly prolong.Yet, because the improvement of living condition makes chronic disease replace various acute infectious diseases, become one of cause of the death main in the civilized society also.In these chronic diseases, especially with diabetes (diabetes) and complication (complication) thereof for.
Diabetes are because the secreted insulin (Insulin) of pancreas in the human body is not enough or act on bad, make sugar part can't be utilized (be about to sugar part and change into heat energy) by human body, and cause sugar part (being blood sugar) concentration in the blood formed a kind of metabolism (metabolism) disease that raises, when blood sugar (blood glucose) concentration of human body surpasses normal value 60～115mg/dl and reaches 180mg/dl, therefore sugar part just can be referred to as diabetes via bladder along with urine is discharged human body.
The cause of disease of diabetes is diversities, may be the infection that is subjected to filterable virus (filtrable virus) by autoimmunity system (auto-immunization), makes that the pancreas beta cell is destroyed, causes the secretion of insulin amount to die-off and falls ill.In addition, also may be because muscle or adipocyte to resistance (insulin resistance) increase of insulin, cause insulin function bad, make that beta cell is withered and pathogenic; Or, and cause blood sugar increasing because in the human body he plants the hormone with anti-insulin and increases; Even be that pancreas is downright bad and cause can't excreting insulin and cause a disease etc.The complication of diabetes then comprises hypoglycemia (hypoglycemia disease), ketoacidosis (Diabetic ketoacidosis; DKA), the non-ketone acid stupor of hypertension hyperosmosis (Nonketotic hyperosmolar syndrome; NKHS) and lacticemia (lacticemia) or the like.
Though much also be difficult to avoid by diabetes or the caused disease of its complication, can reduce or delay the generation of complication via Blood glucose control.Therefore, when more aforesaid symptoms occur, promptly must carry out blood sugar test at once and treat, otherwise, if untimely processing, then may be because hypoglycemia, and cause stupor (coma) dead even.In recent years, utilized the various biological sensors (biosensor) of specific ferment catalytic reaction (enzyme catalytic reaction) to be developed, and be used on the medical application, for example blood-glucose meter.The purposes of this kind biological sensor can be exclusively used on the treatment of diabetes, with the blood-sugar content that helps diabetic's control itself in scope normally.For the diabetic that is in hospital, the blood-sugar content that it can control itself under doctor's supervision is in normal range.But for the non-diabetic that is in hospital, under the situation that the shortage doctor directly supervises, sufferer itself can then become extremely important by self-control of blood sugar content.Therefore, quick, a simple and easy and blood sugar measuring equipment accurately for the diabetic, just seems suitable important.
The existing blood-glucose meter that can detect blood-sugar content on the market voluntarily for the patient, generally comprise the biochip of test cell and a measuring blood content, wherein biochip uses pair of electrodes and cover a responding layer above electrode part, and contain the potassium ferricyanide (potassiumferricyanide) and oxidation ferment (oxidase), for example glucose oxidase ferment (glucoseoxidase) on the responding layer.When using blood-glucose meter to measure, earlier biochip is inserted test cell, then, the skin that the patient can pinprick thorn oneself is to ooze out drop of blood, and the drop of blood that will ooze out (also can be described as a corpse or other object for laboratory examination and chemical testing) directly drops in the biochip that injects test cell again.After being inhaled into the responding layer that is positioned at electrode part top when drop of blood, responding layer can be dissolved.After one period schedule time, after also even this corpse or other object for laboratory examination and chemical testing is finished specific composition (for example ferment of the glucose in the corpse or other object for laboratory examination and chemical testing) catalytic reaction, add that a reference voltage is to biochip, come iron protoxide potassium cyanide (potassium ferrocyanide) with electrochemical reaction (electrochemistryreaction), disengaging electronics, and produce a corresponding kinetic current and pass through electrode.This kinetic current is proportional to the ferrocyanide potassium concn that the ferment catalytic reaction produces or is proportional to concentration of glucose in the blood sample.Because the kinetic current that on biochip, produces, can change and decay gradually in time, so utilize this characteristic, the kinetic current of each time point is amplified via current/voltage converter (Current/VoltageConverter) and convert an output voltage to, can measure a voltage-time discharge curve of the concentration of glucose in corresponding this corpse or other object for laboratory examination and chemical testing then by biochip.Then, again with the pairing output voltage process of each time point analog-digital converter (Analog/DigitalConverter; ADC) convert digital signal and deliver in the microprocessor (microprocessor) and handle to, try to achieve the blood glucose concentration value in the blood sample, at last blood glucose concentration value is come out via a liquid crystal display displays, for patient's reference.
In addition, more some blood-glucose meter is in order to obtain the measuring value of blood sugar concentration fast and accurately, and the standard output voltage-time discharge curve mapping table that is built in the output voltage and with corresponding generation in the microprocessor comes mapping.The standard discharge curve that arrives according to institute's mapping decides its corresponding discharge terminal time again.At last, decide blood-sugar content in the corpse or other object for laboratory examination and chemical testing by microprocessor according to selected standard discharge curve and discharge terminal time thereof again.
Because diabetes are a kind of chronic diseases, so for a blood-glucose meter, its main purpose is providing long-term blood sugar concentration monitoring (surveillance).Therefore, the measurement degree of accuracy of blood-glucose meter is just relatively important.In the blood measuring equipment formerly, its electrode part is formed by two electrodes (i.e. a reaction electrode and a reference electrode).When the user is dropped in a blood corpse or other object for laboratory examination and chemical testing that collects on the responding layer of electrode, if collect blood flow volume when not enough, then can produce the blood drainage very little or situation such as drainage is inhomogeneous, can make the blood sugar concentration generation error that is measured.The generation of this error in measurement can cause medical personnel's erroneous judgement, and then the time that influences the healthy of sufferer and rescue.
Summary of the invention
Because previous blood measuring equipment may not known because the blood flow volume of gathering is not enough, make the measuring value of blood sugar concentration produce error, and may cause the situation of erroneous judgement.The present invention proposes a kind of multi-channel circuit that uses and promotes method and device that blood measures fiduciary level, and one of its fundamental purpose is that the multi-channel circuit that utilizes plurality of electrodes to be connected to form judges whether the amount of bleeding is enough.
Another fundamental purpose of the present invention is the multi-channel circuit that utilizes plurality of electrodes to be connected to form, with the measuring value of different channel circuits through handling, to obtain blood flow volume measured value more accurately.
A fundamental purpose more of the present invention is the multi-channel circuit that utilizes plurality of electrodes to be connected to form, under the enough situation of the judgement amount of bleeding, again with the measuring value of different channel circuits through processing, to obtain blood flow volume measured value accurately.
According to the above object, the invention provides a kind of multi-channel circuit that uses and promote the method that blood measures fiduciary level, comprise: sample of blood, drawn, and fall within on the electrode part of a biological sensor with the minim of bleeding, and after a schedule time, provide a voltage to carry out blood by biological sensor and measure.Then, obtain the measuring value of different passages and carry out digitized processing, obtaining the digital quantity measured value of different passages, and export this digital quantity measured value to micro-control unit.Compare by the difference and the default value of micro-control unit, so that judge whether this amount of bleeding is enough the digital quantity measured value of different passages.At last, again by the micro-control cell processing should the difference passage the digital quantity measured value, obtaining an average magnitude measured value, and carry out the processing of this blood measurement according to this average magnitude measured value.
Then provide a kind of multi-channel circuit that uses to promote the device that blood measures fiduciary level in the present invention, comprise: an electrode part, be made up of plurality of electrodes, an end of this electrode part is connected electrically with biochip simultaneously, and the other end then is connected electrically with the plurality of channels circuit.The plurality of channels circuit, it is made up of the plurality of circuits element, and the one end is connected electrically with electrode part, and the other end then is connected electrically with adding circuit and little processing and control element (PCE).Adding circuit, the one end is connected electrically with the plurality of channels circuit, and the other end then is connected electrically with little processing and control element (PCE).Little processing and control element (PCE), the one end is connected electrically with plurality of channels circuit and adding circuit, and the other end then is connected to an output unit.Wherein above-mentioned multi-channel circuit more comprises: an amplifying circuit, and the one end is connected electrically with electrode part, and the other end then is connected electrically with comparator circuit; One comparator circuit, the one end is connected electrically with amplifying circuit, and the other end then is connected electrically with an A/D conversion circuit; One A/D conversion circuit, the one end is connected electrically with comparator circuit, and the other end then is connected electrically with adding circuit and little processing and control element (PCE).
Description of drawings
Fig. 1 use multi-channel circuit of the present invention promotes the process flow diagram that blood measures fiduciary level;
Fig. 2 use multi-channel circuit of the present invention promotes the function block schematic diagram that blood measures fiduciary level;
The circuit layout synoptic diagram of Fig. 3 corresponding diagram 2;
Fig. 4 use multi-channel circuit of the present invention measures the process flow diagram of the amount of bleeding;
Fig. 5 is the function block schematic diagram of the concrete Fig. 4 of enforcement;
Fig. 6 figure of the present invention uses multi-channel circuit to promote the process flow diagram of blood accuracy of measurement;
Fig. 7 is the function block schematic diagram of the concrete Fig. 6 of enforcement;
Fig. 8 promotes the process flow diagram of the other method of blood accuracy of measurement for the present invention uses multi-channel circuit;
Fig. 9 is the function block schematic diagram of the concrete Fig. 8 of enforcement.
Symbol description among the figure:
10 electrode part
20 channel circuits
21 amplifying circuits
22 comparator circuits
23 A/D conversion circuits
30 little processing and control element (PCE)s
31 adder units
40 adder circuits
Embodiment
Because the element of some biological sensors (Bio-sensor) that used among the present invention utilizes the principle of specific ferment reaction and the processing of measurement with it, in prior art, describe in detail, so in following explanation, the complete measurement process that does not comprise biological sensor, and only do quoting of emphasis formula, its purpose is in the elaboration of assisting feature of the present invention.And the functional block diagram in the accompanying drawing, also not draw according to actual relevant position and complete connection layout, its effect is only being expressed the synoptic diagram relevant with feature of the present invention.In addition, some embodiments of the present invention can be described in detail as follows, yet except describing in detail, the present invention can also be widely in other embodiments, and scope of the present invention do not limited, and are as the criterion with the claim after it.
The present invention at first provides a kind of multi-channel circuit that uses to promote the method that blood measures fiduciary level, comprise: sample of blood, drawn, and fall within on the electrode part of a biological sensor, and after a schedule time, provide a voltage to carry out blood by biological sensor and measure with the minim of bleeding.Then, obtain the measuring value of different passages and carry out digitized processing, obtaining the digital quantity measured value of different passages, and export this digital quantity measured value to micro-control unit.Compare by the difference and the default value of micro-control unit, so that judge whether this amount of bleeding is enough the digital quantity measured value of different passages.At last, again by the micro-control cell processing should the difference passage the digital quantity measured value, obtaining an average magnitude measured value, and carry out the processing of this blood measurement according to this average magnitude measured value.
Then provide a kind of multi-channel circuit that uses to promote the device that blood measures fiduciary level in the present invention, comprise: an electrode part, be made up of plurality of electrodes, an end of this electrode part is connected electrically with biochip simultaneously, and the other end then is connected electrically with the plurality of channels circuit.The plurality of channels circuit, it is made up of the plurality of circuits element, and the one end is connected electrically with electrode part, and the other end then is connected electrically with adding circuit and little processing and control element (PCE).Adding circuit, the one end is connected electrically with the plurality of channels circuit, and the other end then is connected electrically with little processing and control element (PCE).Little processing and control element (PCE), the one end is connected electrically with plurality of channels circuit and adding circuit, and the other end then is connected to an output unit.Wherein above-mentioned multi-channel circuit more comprises: an amplifying circuit, and the one end is connected electrically with electrode part, and the other end then is connected electrically with comparator circuit; One comparator circuit, the one end is connected electrically with amplifying circuit, and the other end then is connected electrically with an A/D conversion circuit; One A/D conversion circuit, the one end is connected electrically with comparator circuit, and the other end then is connected electrically with adding circuit and little processing and control element (PCE).
The present invention also provides a kind of device that uses multi-channel circuit to measure the amount of bleeding, and comprising: an electrode part, to be formed by plurality of electrodes, and an end of its electrode part is connected electrically with a biological chip, and the other end then is connected electrically with the plurality of channels circuit.The plurality of channels circuit, it is made up of a plurality of electronic circuit component, and the one end is connected electrically with electrode part, and the other end then is connected electrically with a little processing and control element (PCE).Little processing and control element (PCE), the one end is connected electrically with the plurality of channels circuit, and the other end then is connected to an output unit.Wherein the electronic circuit component of each passage more comprises: an amplifying circuit, and the one end is connected electrically with electrode part, and the other end then is connected electrically with a comparator circuit; One comparator circuit, the one end is connected electrically with amplifying circuit, and the other end then is connected electrically with an A/D conversion circuit; One A/D conversion circuit, the one end is connected electrically with comparator circuit, and the other end then is connected electrically with adding circuit and this little processing and control element (PCE).
The present invention provides a kind of multi-channel circuit that uses to promote the device that blood measures degree of accuracy again, comprise: an electrode part, be made up of plurality of electrodes, an end of its utmost point portion is connected electrically with a biological chip, and the other end then is connected electrically with the plurality of channels circuit.The plurality of channels circuit, the one end is connected electrically with electrode part, and the other end then is connected electrically with an adding circuit.Adding circuit, the one end is connected electrically with the plurality of channels circuit, and the other end then is connected electrically with an A/D conversion circuit.A/D conversion circuit, the one end is connected electrically with adding circuit, and the other end then is connected electrically with a little processing and control element (PCE).Little processing and control element (PCE), the one end is connected electrically with A/D conversion circuit, and the other end then is connected to an output unit.
Next, will describe concrete method and the device of implementing thereof of the present invention in detail by Fig. 1 to Fig. 9.
Fig. 1 is used for illustrating that use multi-channel circuit of the present invention promotes the process flow diagram that blood measures fiduciary level.At first, from step 110, it can ooze out the blood sample of drop of blood as a corpse or other object for laboratory examination and chemical testing so that gather by the skin of patient with pinprick thorn oneself.Then, the drop of blood that will ooze out (also can be described as a corpse or other object for laboratory examination and chemical testing) directly drops in the biochip that injects test cell again, be inhaled into the responding layer that is positioned at electrode part top when drop of blood after, responding layer can be dissolved.After one period schedule time, apply a reference voltage to biochip by biological sensor, measure so that carry out blood, shown in step 120.After reference voltage adds on the biochip, can cause that promptly electrochemical reaction comes iron protoxide potassium cyanide, disengage electronics then, to produce a corresponding kinetic current and to pass through electrode, by different channel circuits kinetic current is amplified and converts to the discharge curve of a voltage then, read the magnitude of voltage of a set point then, for example, read the maximal value of voltage discharge curve.Again this voltage and fixed-bias transistor circuit (bias) are compared, to obtain the measuring value of different channel circuits, shown in step 130.Then, the magnitude of voltage digitizing that will measure by step 140, and digitized measurement magnitude of voltage in the different channel circuits delivered to little processing and control element (PCE), with the difference of the measurement magnitude of voltage between more different channel circuits.Then, again this difference and a default value (default) are compared in little processing and control element (PCE) once more.When the difference that measures magnitude of voltage during greater than default value, represent that then blood flow volume gathers not enoughly, make the amount of the bleeding inequality that is distributed in electrode part, and cause the measurement magnitude of voltage difference of different channel circuits excessive.Because the measurement magnitude of voltage difference between different channel circuits is excessive, so its obtained average voltage level can produce deviation, and the measurement that leads to errors.At this moment, promptly must get back to step 110, carry out blood again and must gather, and carry out aforesaid program.When the difference that measures magnitude of voltage during less than default value, represent that then the amount of bleeding of blood is enough, make blood be evenly distributed in electrode part.Therefore, the difference at the measurement magnitude of voltage of different channel circuits can be very little.Because the measurement magnitude of voltage between different channel circuits is approaching, thus its via the obtained average voltage level of step 150 can be relative truly, and can obtain more accurate measurement.Then, again the average voltage level that is obtained is delivered in little processing and control element (PCE) via step 160 and handled, try to achieve the measurement of the blood glucose concentration value in the blood sample, at last blood glucose concentration value is come out via a liquid crystal display displays, for medical personnel or patient's reference.
Fig. 2 promotes the function block schematic diagram that blood measures fiduciary level for the present invention uses multi-channel circuit, and its detailed operating process is described as follows.
When drop of blood be inhaled into be positioned at electrode part 10 after, blood can be distributed in the responding layer on P1, P2 and the P3 electrode.After biological sensor is added to a reference voltage on the biochip, can cause that promptly electrochemical reaction comes iron protoxide potassium cyanide, disengage electronics then, to produce a corresponding kinetic current (reaction current) and by P1, P2 and P3 electrode.Then, kinetic current is amplified, and convert kinetic current to export to behind the magnitude of voltage in the channel circuit 20 comparator circuit 22 by (the Current to VoltageConverter) 21 of the current/voltage-converted circuit in the different channel circuit 20.When comparator circuit 22 receives the magnitude of voltage exported by preamplifying circuit 21 and by fixed-bias transistor circuit (bias) V that biological sensor provided
bAfter, compare with being about to this two voltage, and export one through A/D conversion circuit (the Analog to Digital Converter of the voltage difference after relatively to the channel circuit 20; ADC) 23, obtaining a digitized magnitude of voltage, and with the measuring value of this digitized magnitude of voltage as different channel circuits 20.Then, the digitized measurement magnitude of voltage of process that is obtained on the different channel circuits 20 is delivered to a micro-control unit (Micro-processing Control Unit; MCU) in 30, after handling via micro-control unit 30, obtain the voltage difference of 20 of different channel circuits, again this voltage difference and a default value (default) are compared once more.When the voltage difference of 20 of different channel circuits during greater than default value, represent that then blood flow volume gathers not enoughly, must carry out the program that blood must be gathered and measure again.When the voltage difference of 20 of different channel circuits during less than default value, the amount of bleeding of then representing blood is enough, at this moment, after by the addition electric unit 31 in the micro-control unit 30 magnitude of voltage of different channel circuits being carried out addition and average treatment, to obtain an average voltage level, handle by micro-control unit 30 more immediately, in the hope of the measurement of the blood glucose concentration value in the blood sample.For example, come mapping according to the standard output voltage-time discharge curve mapping table that is built in average voltage level and in the microprocessor.The standard discharge curve that arrives according to institute's mapping decides its corresponding discharge terminal time again.At last, decide blood-sugar content in the corpse or other object for laboratory examination and chemical testing by microprocessor according to selected standard discharge curve and discharge terminal time thereof again.
For specifying the operating process of multi-channel circuit of the present invention, side circuit schematic layout pattern shown in Figure 3 illustrates.When drop of blood be inhaled into be positioned at electrode part 10 after, blood can be distributed in the responding layer on P1, P2 and the P3 electrode.Then, biological sensor can provide a reference voltage (reference voltage; V
Ref), V for example
Ref=550 millivolts (mv), and after being added to reference voltage on the biochip, make responding layer produce a corresponding kinetic current (reactioncurrent) also by P1, P2 and P3 electrode.Then, kinetic current through one by operation amplifier circuit 1 (Operation Amplifier; OP1) formed current/voltage-converted circuit (Current to Voltage Converter) 21, so that convert kinetic current to a magnitude of voltage, to obtain the discharge curve of a voltage, wherein the yield value of the magnification of OP1 (Gain) is
Gain＝(1+R
15/R
12)×V
b
V wherein
bBe a fixed-bias transistor circuit (bias), and R
12=R
1, R
15=R
5
Follow again, export the resulting magnitude of voltage of OP1 to one by operation amplifier circuit 2 (Operation Amplifier; OP2) institute's shape comparator circuit 22.For example, be a subtraction circuit (subtraction circuit) by the formed comparator circuit 22 of OP2.When subtraction circuit receives the magnitude of voltage exported by OP1 and by fixed-bias transistor circuit (bias) V that biological sensor provided
bAfter, subtraction circuit compares with being about to this two voltage, and exports a voltage difference.For example, when the maximum voltage value that OP1 read is 900mv, and V
bDuring=300mv, be 600mv then at the resulting output voltage values of OP1; In like manner, if the formed current/voltage-converted circuit of operation amplifier circuit OP3 on the another one channel circuit, when the maximum voltage value that it read was 1V (being 1000mv), then the subtraction circuit on this passage (OP4) institute output voltage difference was 700mv.Follow again, be about to the voltage difference that different channel circuits 20 are obtained and deliver to A/D conversion circuit (ADC) 23 respectively, to obtain a digitized magnitude of voltage.Then, the digitized measurement magnitude of voltage of process that is obtained on the different channel circuits 20 is delivered in the micro-control unit (MCU) 30, after handling via micro-control unit 30, obtained the voltage difference of 20 of different channel circuits, as precedent, the voltage difference that two channel circuits are 20 is 100mv.Again this voltage difference and a default value (default) are compared once more.For example, when the default value that is provided when the micro-control unit is 150mv, at this moment, the voltage difference (100mv) that two channel circuits are 20 is less than default value (150mv), the amount of bleeding of then representing blood is enough, therefore, micro-control unit 30 receives the magnitude of voltage (being 1900mv) that is transmitted by the formed adding circuit 40 of operation amplifier circuit OP5, and after obtaining average voltage level (being 950mv) by micro-control unit 30, standard output voltage-time discharge curve mapping the table that is built in this average voltage level and one in the micro-control unit can be come mapping, try to achieve the measurement of the blood glucose concentration value in the blood sample at last by micro-control unit 30.Anti-, the voltage difference that two channel circuits are 20 is during greater than default value, then represent blood flow volume gather not enough, the program that must carry out the collection and the measurement of blood again.Therefore, micro-control unit 30 does not receive adding circuit (adder) 40 magnitudes of voltage that transmitted by OP4.Adding circuit 40 in this circuit emphasizes that it is configurable in channel circuit, also can in be built in little processing and control element (PCE) 30.
Because modern computer-aided design (CAD) and manufacturing (CAD/CAM) technology are constantly innovated, make also significantly to promote in design (design), the emulation (simulation) of circuit and the function of making on (manufacturing).Based on this viewpoint, the function that the aforesaid multi-channel circuit of the present invention is had, bleeding in the time of can being broken down into blood measurement measures trial assembly and puts device two parts that measure degree of accuracy with a raising blood, wherein the measurement trial assembly of bleeding can be put with other biological sensor merging and use, and in the use of the device that improves blood measurement degree of accuracy, it is except can more becoming a blood measuring equipment separately with other biological sensor combines.About bleeding after decomposing measures examination and improves the mode of operation that blood measures degree of accuracy, to illustrate in following paragraph that only the circuit structure because of both is identical with previous embodiment, so under the exposure that does not influence feature of the present invention, only do the narration of emphasis, to avoid too much repeat specification.
Fig. 4 bleeds for use multi-channel circuit of the present invention and measures the flow process of examination, wherein step 410～step 440 is identical with step 110～step 140, after gathering a blood sample, then blood is directly dropped on the biochip that has injected test cell immediately, after one period schedule time, apply a reference voltage and measure so that carry out blood, by different channel circuits kinetic current is amplified and converts to the discharge curve of a voltage then, and read the magnitude of voltage of a set point, the then magnitude of voltage digitizing that will measure again.Then, digitized measurement magnitude of voltage is delivered to the also difference of the measurement magnitude of voltage between more different channel circuits of a processing unit, again this difference and a default value (default) are compared once more.When the difference that measures magnitude of voltage during greater than default value, represent that then blood flow volume gathers not enoughly, must get back to the program that step 410 is carried out the collection and the measurement of blood again.When the difference that measures magnitude of voltage during less than default value, represent that then the amount of bleeding of blood is enough, then will be bled by step 450 measures the outcome record of examination and comes out via a liquid crystal display displays, for medical personnel or patient's reference.The 5th figure is that use multi-channel circuit of the present invention is bled and measured the function block schematic diagram of examination, because its circuit structure and Fig. 2 (except totalizer 40) much at one, so its detailed course of work please refer to the description of earlier figures 2.
Fig. 6 promotes the flow process that blood measures degree of accuracy for use multi-channel circuit of the present invention, wherein step 610～step 640 is identical with step 110～step 140 and the step 410～step 440 among the 4th figure among first figure, after gathering a blood sample, directly drop in blood on the biochip, after one period schedule time, apply a reference voltage so that carrying out blood measures, obtain a magnitude of voltage by different channel circuits then, the magnitude of voltage digitizing that will measure.Then, handle by step 650 pair digitized measurement magnitude of voltage, with obtain one measure voltage and.Follow again, to measure delivering to a processing unit with value and handling of voltage by step 660, and obtain an average voltage level, and the average voltage level that obtains with being about to in standard output voltage-time discharge curve mapping table of being built in this little processing and control element (PCE) come mapping, and then try to achieve the measurement of the blood glucose concentration value in the blood sample.At last, the measurement of blood glucose concentration value is write down and come out by step 670, for medical personnel or patient's reference via a liquid crystal display displays.Fig. 7 is that use multi-channel circuit of the present invention promotes the function block schematic diagram that blood measures degree of accuracy, because its circuit structure and Fig. 2 are approximate, so its detailed course of work compresses as follows:
When drop of blood be inhaled into be positioned at electrode part 10 and be distributed in P1, P2 and the P3 electrode on responding layer after, provide a reference voltage subsequently to biochip, to produce a corresponding kinetic current and by P1, P2 and P3 electrode.Then, amplify via different current/voltage-converted circuit 21 respectively, so that kinetic current is converted to a magnitude of voltage and exports this magnitude of voltage to A/D conversion circuit 23, to obtain a digitized magnitude of voltage.Then, will deliver to adder unit 31 in the micro-control unit 30 through digitized different measurement magnitude of voltage, with the magnitude of voltage of making a profit and.Handling in micro-control unit 30 this voltage again with value, and after obtaining an average voltage level, with be about to this average voltage level with in standard output voltage-time discharge curve mapping table of being built in this little processing and control element (PCE) come mapping, and then try to achieve the measurement of the blood glucose concentration value in the blood sample.Because the measurement of this blood glucose concentration value is through the different different kinetic currents of circuit acquisition, and after the magnitude of voltage after will changing passed through average treatment again, the value that its resulting actual amount measured value can more only use single circuit and be measured came correctly, precisely and reliable.
For using multi-channel circuit to promote on the device and method of blood measurement degree of accuracy, also can do different combinations via the characteristic of electronic component.For example, process flow diagram shown in Figure 8 is another embodiment of the present invention.As shown in Figure 8, its with Fig. 6 between difference after obtaining to measure magnitude of voltage via different channel circuit, try to achieve earlier different channel circuits the measurement magnitude of voltage and, and then carry out digitized processing.In addition, all identical as the described process of Fig. 8 and Fig. 6.Also therefore, circuit differences on Fig. 9 and Fig. 7, also only after amplifying via different current/voltage-converted circuit 21 respectively when kinetic current, earlier via the magnitude of voltage addition of a totalizer 40 with conversion, and then export the voltage after the process addition and be worth A/D conversion circuit 23, to obtain a digitized magnitude of voltage.In addition, the effect of all the other each circuit components is all identical with Fig. 7.
Above-mentionedly being totalizer 40 about the difference between Fig. 7 and Fig. 9, is a digital totalizer among Fig. 7 wherein, then is an analog totalizer among Fig. 9.Because analog adder has reaction velocity faster compared to digital adder, uses the analog adder circuit can use digital adder circuit to use an analog/digital converter (ADC) less simultaneously.Therefore, in the selection of the method for using lifting blood measurement degree of accuracy and device, the present invention will be a preferred embodiment with the multi-channel circuit among Fig. 9.
For knowing circuit designers, it can do different combinations and application according to the disclosed circuit of the present invention.For example, it can change totalizer tie point among Fig. 2 between amplifier 21 and the comparer 22, then, allows totalizer through an analog/digital converter and be connected to the micro-control unit again.So combination, though can use an analog/digital converter, it can reach purpose of the present invention equally more.In addition, more can further specifically implement according to circuit layout (layout) shown in Figure 3.So comprehensive above described content, it only is preferred embodiment of the present invention, and its all contents that disclosed are not in order to limit claim of the present invention; All other do not break away from the equivalence of being finished under the disclosed spirit and changes or modification, all should be included in the following claim.
Claims (25)
1. one kind is used multi-channel circuit to promote the method that blood measures fiduciary level, it is characterized in that, comprising:
Sample of blood, drawn, and fall within on the electrode part of a biological sensor with the minim of bleeding;
Carry out blood and measure, fall within on this electrode part after the schedule time, provide a voltage to carry out by this biological sensor in this minim of bleeding;
Obtain the measuring value of different passages;
Digitizing should the difference passage measuring value, and export this digital quantity measured value to micro-control unit;
The difference and a default value of digital quantity measured value that relatively should the difference passage are so that judge by this micro-control unit whether this amount of bleeding is enough; And
Handle the digital quantity measured value of this difference passage, obtaining an average magnitude measured value, and carry out the processing of this blood measurement according to this average magnitude measured value by this micro-control unit.
2. use multi-channel circuit as claimed in claim 1 promotes the method that blood measures fiduciary level, and wherein this electrode part is made up of three electrode members of any geometry arrangement.
3. use multi-channel circuit as claimed in claim 1 promotes the method that blood measures fiduciary level, and wherein this default value is one to be preset in the integer in this micro-control unit.
4. use multi-channel circuit as claimed in claim 1 promotes the method that blood measures fiduciary level, and wherein this default value can be adjusted by this biological sensor.
5. use multi-channel circuit as claimed in claim 1 promotes the method that blood measures fiduciary level, and the difference of digital quantity measured value that wherein should the difference passage judges with the comparison size whether this amount of bleeding is enough with this default value.
6. use multi-channel circuit as claimed in claim 5 promotes the method that blood measures fiduciary level, and the difference of digital quantity measured value that wherein should the difference passage is during greater than this default value, again sample of blood, drawn.
7. use multi-channel circuit as claimed in claim 5 promotes the method that blood measures fiduciary level, and the difference of digital quantity measured value that wherein should the difference passage is carried out the processing of this average magnitude measured value during less than this default value.
8. one kind is used multi-channel circuit to promote the device that blood measures fiduciary level, it is characterized in that, comprising:
One electrode part is made up of plurality of electrodes, measures in order to carry out blood, to export a kinetic current;
The plurality of channels circuit is made up of the plurality of circuits element, in order to obtain the digitizing measuring value of different passages;
One little processing and control element (PCE) has a default value of judging the amount of bleeding, has the digital quantity measured value of handling this difference passage simultaneously, obtaining an average magnitude measured value, and carries out the processing of this blood measurement by this micro-control unit according to this average magnitude measured value.
9. use multi-channel circuit as claimed in claim 8 promotes the device that blood measures fiduciary level, and wherein this electrode part is made up of three electrode members of any geometry arrangement, and is coated with a responding layer on these three electrode members.
10. use multi-channel circuit as claimed in claim 9 promotes the device that blood measures fiduciary level, and wherein this responding layer is formed by having the material that reacts with blood.
11. use multi-channel circuit as claimed in claim 8 promotes the device that blood measures fiduciary level, wherein this plurality of channels circuit is made up of the formed passage of a plurality of different electronic circuit components, and wherein the electronic circuit component of this each passage more comprises:
One amplifying circuit, the one end is connected electrically with this electrode part;
One comparator circuit, the one end is connected electrically with the other end of this amplifying circuit;
One A/D conversion circuit, the one end is connected electrically with the other end of this comparator circuit, and the other end then is connected electrically with this little processing and control element (PCE).
12. use multi-channel circuit as claimed in claim 11 promotes the device that blood measures fiduciary level, wherein the other end of this A/D conversion circuit is connected electrically with an adding circuit.
13. use multi-channel circuit as claimed in claim 8 promotes the device that blood measures fiduciary level, wherein this little processing and control element (PCE) has the digital voltage value of different channel circuits is handled, to obtain the difference of a digital voltage, and the difference of this digital voltage and this default value that is pre-set in this little processing and control element (PCE) compared processing, and export a control signal corresponding.
14. use multi-channel circuit as claimed in claim 13 promotes the device that blood measures fiduciary level, wherein the result that handles of the difference of this digital voltage and this default value is that this digital voltage difference is during greater than this default value, then, carry out the program that blood must be gathered and measure again according to this corresponding control signal of this micro-control unit output.
15. use multi-channel circuit as claimed in claim 13 promotes the device that blood measures fiduciary level, wherein the result that handles of the difference of this digital voltage and this default value is that this digital voltage difference is during less than this default value, then comply with this corresponding control signal of this micro-control unit output, then receive the voltage and the value that transmit by this adding circuit, and in this little processing and control element (PCE), handle, to obtain an average voltage level, simultaneously this little processing and control element (PCE) and according to this average voltage level carry out the processing of measurement.
16. a method of using multi-channel circuit to measure the amount of bleeding comprises:
Sample of blood, drawn, and fall within on the electrode part of a biological sensor with the minim of bleeding;
Carry out blood and measure, fall within on this electrode part after the schedule time, provide a voltage to carry out by this biological sensor in this minim of bleeding;
Obtain the measuring value of different passages;
Digitizing should the difference passage measuring value, and export this digital quantity measured value to micro-control unit; And
A digital measurement value difference value and a default value that relatively should the difference passage be so that judge by this micro-control unit whether this amount of bleeding is enough.
17. use multi-channel circuit as claimed in claim 16 measures the method for the amount of bleeding, wherein this electrode part is made up of three electrode members of any geometry arrangement.
18. use multi-channel circuit as claimed in claim 16 measures the method for the amount of bleeding, wherein this default value is one to be preset in the integer in this micro-control unit.
19. use multi-channel circuit as claimed in claim 18 measures the method for the amount of bleeding, wherein this default value can be adjusted by this biological sensor.
20. use multi-channel circuit as claimed in claim 16 measures the method for the amount of bleeding, the difference of digital quantity measured value that wherein should the difference passage judges with the comparison size whether this amount of bleeding is enough with this default value.
21. one kind is used multi-channel circuit to promote the method that blood measures degree of accuracy, comprising:
Sample of blood, drawn, and this blood sample drips on an electrode part of a biological sensor;
Carry out blood and measure, drip after a schedule time on this electrode part, provide a voltage to carry out by this biological sensor in this blood sample;
Obtain the measuring value of different passages, after this measuring value is handled through this difference channel circuit, with the measuring value of obtaining this difference passage and export this measuring value to one adder circuit;
Obtaining one of different passages measures and value;
Digitizing should measure and value, and exported this digitizing measurement and little processing and control element (PCE) of value to;
Handle this digital measurement and value, obtaining an average magnitude measured value, and by carrying out the processing of this blood measurement according to this average magnitude measured value.
22. use multi-channel circuit as claimed in claim 21 promotes the method that blood measures degree of accuracy, wherein this electrode part is made up of three electrode members of any geometry arrangement.
23. one kind is used multi-channel circuit to promote the device that blood measures degree of accuracy, comprising:
One electrode part is made up of plurality of electrodes, measures in order to carry out blood, to export a kinetic current;
The plurality of channels circuit is made up of the plurality of circuits element, in order to obtain the digitizing measuring value of different passages;
One adding circuit is in order to the magnitude of voltage addition with different passages;
One A/D conversion circuit carries out digitized processing with magnitude of voltage;
One little processing and control element (PCE) has the digital quantity measured value of handling this difference passage, obtaining an average magnitude measured value, and carries out the processing of this blood measurement by this micro-control unit according to this average magnitude measured value.
24. use multi-channel circuit as claimed in claim 23 promotes the device that blood measures degree of accuracy, wherein this electrode part is made up of three electrode members of any geometry arrangement, and is coated with a responding layer on these three electrode members.
25. use multi-channel circuit as claimed in claim 23 promotes the device that blood measures degree of accuracy, wherein this responding layer can be formed with the material that blood reacts by one.
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| CNB2003101012563A CN100356168C (en) | 2003-10-16 | 2003-10-16 | Method and apparatus for improving blood measurement reliability using multi-channel circuit |
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| CNB2003101012563A CN100356168C (en) | 2003-10-16 | 2003-10-16 | Method and apparatus for improving blood measurement reliability using multi-channel circuit |
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| CN100356168C CN100356168C (en) | 2007-12-19 |
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| WO2010135978A1 (en) * | 2009-05-25 | 2010-12-02 | 利多(香港)有限公司 | Biosensor and usage thereof |
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| CN106706732A (en) * | 2016-12-26 | 2017-05-24 | 安徽省碧水电子技术有限公司 | Water quality detection system based on bi-polar system |
| CN106770533A (en) * | 2016-12-26 | 2017-05-31 | 安徽省碧水电子技术有限公司 | It is a kind of with voice broadcast based on the two poles of the earth system water quality detection system |
| CN106770593A (en) * | 2016-12-26 | 2017-05-31 | 安徽省碧水电子技术有限公司 | It is a kind of with purging system based on the two poles of the earth system water quality detection system |
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| US5494562A (en) * | 1994-06-27 | 1996-02-27 | Ciba Corning Diagnostics Corp. | Electrochemical sensors |
| JP2002189014A (en) * | 2000-12-20 | 2002-07-05 | Sankyo Co Ltd | Enzyme electrode |
| CN1234873C (en) * | 2003-04-03 | 2006-01-04 | 上海新立医疗器械有限公司 | Test paper matched to blood sugar tester and its preparing method |
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| US8834702B2 (en) | 2009-05-25 | 2014-09-16 | Leadway (Hk) Limited | Biosensor and usage thereof |
| WO2010135978A1 (en) * | 2009-05-25 | 2010-12-02 | 利多(香港)有限公司 | Biosensor and usage thereof |
| CN101900701B (en) * | 2009-05-25 | 2014-07-16 | 利多(香港)有限公司 | Biosensor |
| US9335291B2 (en) | 2009-12-11 | 2016-05-10 | Lifescan Scotland Limited | Fill sufficiency method and system |
| CN102147388B (en) * | 2009-12-11 | 2014-12-03 | 生命扫描苏格兰有限公司 | Method and system for detecting fill sufficiency |
| US8936713B2 (en) | 2009-12-11 | 2015-01-20 | Lifescan Scotland Limited | Fill sufficiency method and system |
| CN102147388A (en) * | 2009-12-11 | 2011-08-10 | 生命扫描苏格兰有限公司 | Method and system for detecting fill sufficiency |
| CN106706732A (en) * | 2016-12-26 | 2017-05-24 | 安徽省碧水电子技术有限公司 | Water quality detection system based on bi-polar system |
| CN106770533A (en) * | 2016-12-26 | 2017-05-31 | 安徽省碧水电子技术有限公司 | It is a kind of with voice broadcast based on the two poles of the earth system water quality detection system |
| CN106770593A (en) * | 2016-12-26 | 2017-05-31 | 安徽省碧水电子技术有限公司 | It is a kind of with purging system based on the two poles of the earth system water quality detection system |
| CN106770534A (en) * | 2016-12-26 | 2017-05-31 | 安徽省碧水电子技术有限公司 | It is a kind of with temperature sensor based on the two poles of the earth system water quality detection system |
| CN106841359A (en) * | 2016-12-26 | 2017-06-13 | 安徽省碧水电子技术有限公司 | It is a kind of with standard value contrast based on the two poles of the earth system water quality detection system |
| CN111307889A (en) * | 2020-04-14 | 2020-06-19 | 漳州卫生职业学院 | High-precision blood glucose detection device |
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