CN1256584C - Biological chip capable of raising measurement reliability and its method - Google Patents
Biological chip capable of raising measurement reliability and its method Download PDFInfo
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- CN1256584C CN1256584C CN 03101039 CN03101039A CN1256584C CN 1256584 C CN1256584 C CN 1256584C CN 03101039 CN03101039 CN 03101039 CN 03101039 A CN03101039 A CN 03101039A CN 1256584 C CN1256584 C CN 1256584C
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Abstract
The present invention relates to biochips capable of enhancing measuring reliability and a method thereof. A resistor whose the resistance value is equivalent to or appreciably larger than the maximum resistance value of the R<s> is connected to biochips with a resistor R<s> so as to compensate the difference of the resistance value among the biochips, so that the noise ratio value (N/S) of the biochips is reduced so as to enhanced the measuring reliability of the biochips.
Description
Technical field
The present invention relates to a kind of biology sensor; Particularly a kind of have can improve biology sensor and the method thereof of measuring the confidence level biochip.
Background technology
In recent years, utilizing the various biology sensors of specific ferment catalytic reaction to be developed is used on the medical application.A kind of purposes of this kind biology sensor is to be used for treatment of diabetes, with the blood-sugar content (concentration of glucose in the blood) that helps diabetic's control itself in scope normally.For the diabetic that is in hospital, the blood-sugar content that it can control itself under doctor's supervision is in normal range.But for the non-diabetic that is in hospital, under the situation that the shortage doctor directly supervises, sufferer itself can then become extremely important by self-control of blood sugar content.
Oneself's control of blood-sugar content can be reached by diet, motion and medication.These therapeutic modalities adopt under doctor's supervision usually simultaneously.When diabetic itself can detect its blood-sugar content whether in normal range, can help more effectively its blood-sugar content of oneself's control of patient.
Fig. 1 shows that a kind of patient of supplying detects the blood-glucose meter of blood-sugar content voluntarily, and it comprises a main test cell 10 and a biochip 12 for measuring blood content.With reference to shown in Figure 2, be biochip 12 member decomposing schematic representations, it comprises that front end is provided with a strip substrate 122 of an electrode part 1221.Electrode part 1221 tops cover a responding layer 124, a spacing body 126 and a cover plate 128.Electrode part 1221 is provided with an operation electrode 1222 and a corresponding electrode 1224 surrounds this operation electrode 1222.Operation electrode 1222 and counter electrode 1224 are electrically connected to a lead 1226 and the lead 1228 that is positioned at strip substrate 122 tail ends respectively.The responding layer 124 that is covered in electrode part 1221 tops contains the potassium ferricyanide (potassium ferricyanide) and oxidase (oxidase), for example glucose oxidase (glucose oxidase).
When stating blood-glucose meter in the use, earlier biochip 12 is inserted main test cell 10.Then, the skin that the patient can lancet thorn oneself is to ooze out drop of blood, and the drop of blood that will ooze out directly drops in the opening 129 of biochip 12 closing panels 128 that injected main test cell 10 again.This drop of blood is inhaled into the responding layer 124 that is positioned at electrode part 1221 tops via a passage 127 of spacing body 126, and with responding layer 124 dissolving, carrying out-the ferment catalytic reaction, shown in following reaction equation:
Concentration of glucose in the corresponding blood sample of the potassium ferrocyanide of one scheduled volume (potassium ferrocyanide) and producing.After finishing through the ferment catalytic reaction of glucose in the blood sample after one period schedule time, an effect voltage V
RefBestow on the operation electrode 1222 of biochip 12,,, pass through operation electrode 1222 and produce a corresponding kinetic current to disengage electronics with electrochemical reaction ground iron protoxide potassium cyanide.This kinetic current is proportional to the ferrocyanide potassium concn that the ferment catalytic reaction produces or is proportional to concentration of glucose in the blood sample.Main test cell 10 electrically connects with the lead 1226 and 1228 of biochip 12 strip substrates 122 tail ends, and records this kinetic current of the operation electrode 1222 of flowing through via lead 1226 and 1228.Can obtain concentration of glucose in the blood sample by measuring this kinetic current.
Fig. 3 is the control circuit synoptic diagram of blood-glucose meter shown in Figure 1, wherein the operation electrode 1222 of biochip 12 electrode part 1221 and the counter electrode 1224 visual resistance R of doing
s, effect voltage V
RefCan be by a battery supplied.The kinetic current I that biochip 12 produces has amplification resistance (amplification resistance) R via one
fCurrent/voltage converter 32 convert an output voltage V to
OutThis output voltage V
OutCan represent by formula (I):
V
out＝(1+R
f/R
s)V
ref (I)，
One microprocessor (microcomputer) (not shown) is handled this output voltage V via an analog-digital converter (not shown)
Out, in the hope of the glucose concentration value in the blood sample, via a LCD (not shown) this glucose concentration value is shown again, for patient's reference.
Yet the biochip 12 of above-mentioned existing blood-glucose meter can produce resistance R between the biochip 12 in manufacture process
sDifference.Generally speaking, the resistance R of biochip 12
sBetween 2K to 4K, resistance R between the biochip 12
sDifference, make each biochip 12 but record different output voltage V for the same blood sample
Out, and obtain different glucose concentration value.Therefore, resistance R between the biochip 12
sDifference, reduced the measurement confidence level (reliability) of biochip 12.
In view of the above, demand providing a kind of biochip of measuring confidence level that improves urgently, it can overcome the disappearance that resistance value difference causes between the existing biochip.
Summary of the invention
Fundamental purpose of the present invention is to overcome the deficiencies in the prior art and defective, a kind of biochip of measuring confidence level that improves is provided, it quite or approximately is slightly larger than a resistance of the maximum resistance of biochip own on biochip by being connected in series a resistance value, with the resistance value difference between the compensation biochip, and then the measurement confidence level of raising biochip.
Another object of the present invention provides a kind of biochip of measuring confidence level that improves, and it can improve the accuracy of measurement of a specific components and concentration in the tested corpse or other object for laboratory examination and chemical testing.
Another purpose of the present invention provides a kind of method that biochip is measured confidence level that improves, it utilizes the method that increases biochip last action electrode and its counter electrode length or width, to be connected in series a resistance on biochip, thereby reduce the difference of resistance value between each biochip, and then improve the measurement confidence level of biochip.The inventive method is simple, need not increase extra manufacturing step, can reach the purpose that reduces manufacturing cost.
According to above-described purpose, the invention provides a kind of biochip and method thereof of measuring confidence level that improve.Biochip of the present invention comprises a substrate, a responding layer, a spacing body and a cover plate.Substrate has a first end and a second end, and first end has operation electrode and a corresponding electrode spaced apart from each other, and a resistance string is connected to the operation electrode, and the second end has one first lead and one second lead.The operation electrode of substrate first end and counter electrode are formed with a maximum resistance R
s, and the resistance value of this resistance that is serially connected with the operation electrode quite or approximately is slightly larger than this maximum resistance R
sOperation electrode and counter electrode are electrically connected at first lead and second lead respectively from the first end of substrate, reach the main test cell that first lead and second lead are electrically connected at a biological sensor, this main test cell is used for measuring the kinetic current that this biochip corresponding one a tested corpse or other object for laboratory examination and chemical testing one specific composition produces in the operation electrode.Responding layer is positioned at the first end top of substrate with overlapping operation electrode and counter electrode, this responding layer comprises a redox mediators and a ferment, wherein redox mediators with bestow that this specific composition carries out a redox reaction through ferment catalysis in the tested corpse or other object for laboratory examination and chemical testing on biochip.Spacing body is positioned at this responding layer top, and this spacing body is provided with the end of a passage in the respective reaction layer.Cover plate is positioned at the spacing body top, and this cover plate is provided with one and is opened on above the passage of spacing body, so that a tested corpse or other object for laboratory examination and chemical testing is through opening and passage enter responding layer thus.
The present invention quite or approximately is slightly larger than the resistance of the maximum resistance of biochip own on biochip by being connected in series a resistance value, to compensate the difference of resistance value between each biochip, than (N/S) value, and then improve the accuracy of measurement of a specific components and concentration in the measurement confidence level (reliability) of biochip and the tested corpse or other object for laboratory examination and chemical testing with the noise that reduces biochip.
Description of drawings
Fig. 1 is an existing blood sugar machine schematic appearance;
Fig. 2 is a biological chip component decomposing schematic representation of blood sugar machine shown in Figure 1;
Fig. 3 is the control circuit synoptic diagram of blood sugar machine shown in Figure 1;
Fig. 4 is the part control circuit synoptic diagram of biology sensor of the present invention;
Fig. 5 is the substrate skeleton view of the one biological chip of one first preferred embodiment according to the present invention;
Fig. 6 is the substrate skeleton view of the one biological chip of one second preferred embodiment according to the present invention;
Fig. 7 is the substrate skeleton view of the one biological chip of one the 3rd preferred embodiment according to the present invention.
Symbol description among the figure
10 main test cells
12 biochips
122 strip substrates
1221 electrode part
124 responding layers
126 spacing bodies
127 passages
128 cover plates
129 openings
1222 operation electrodes
1224 counter electrodes
1226,1228 leads
30 current/voltage converters
40 current/voltage converters
50 substrates
51 first ends
52 the second ends
511 operation electrodes
512 counter electrodes
521 first leads
522 second leads
60 substrates
61 first ends
62 the second ends
611 operation electrodes
612 counter electrodes
621 first leads
622 second leads
70 substrates
71 first ends
72 the second ends
711 operation electrodes
712 counter electrodes
721 first leads
722 second leads
Embodiment
Be applied to biology sensor main member of the present invention and be same as existing blood-glucose meter main member shown in Figure 1, all comprise a biological chip and a main test cell.When using biology sensor of the present invention, earlier biochip is inserted in the main test cell, then a tested corpse or other object for laboratory examination and chemical testing is bestowed on biochip, measure a kinetic current of a specific composition generation in the corresponding tested corpse or other object for laboratory examination and chemical testing of biochip again by main test cell.Main test cell again according to this measured kinetic current to determine this specific components and concentration in the tested corpse or other object for laboratory examination and chemical testing.Biochip of the present invention comprises a substrate, a responding layer, a spacing body and a cover plate.The substrate of biochip of the present invention has a first end and a second end, and wherein first end has an operation electrode and a corresponding electrode spaced apart from each other.The kinetic current that this specific composition produces in the corresponding tested corpse or other object for laboratory examination and chemical testing of the biochip of the present invention operation electrode of flowing through is so operation electrode and the visual resistance R of doing of counter electrode
sGenerally speaking, the resistance R that each biochip had
sSize can be variant, this resistance R
sBetween 2K to 4K.For compensating resistance R between each biochip
sDifference, the present invention is connected in series the resistance R that a resistance value quite or approximately is slightly larger than the maximum resistance of biochip own on biochip, for example be connected in series the resistance R of a 4K, makes the resistance value difference between each biochip become 6K to 8K.Thus, biochip can be from original noise than (N/S) for 1K/3K reduces to 1K/7K, and then improve the measurement confidence level of each biochip.
The second end of biochip substrate of the present invention has one first lead and one second lead, the operation electrode of first end and counter electrode are electrically connected at first lead and second lead of the second end respectively from the first end of substrate, and first lead and second lead be electrically connected at the main test cell of biology sensor, thereby make main test cell measure the kinetic current that this specific composition produces in the operation electrode in the corresponding tested corpse or other object for laboratory examination and chemical testing of this biochip.The first end top of the responding layer seat substrate of biochip is with overlapping operation electrode and counter electrode.This responding layer comprises a redox mediators (redox mediator) and a ferment, and this redox mediators carries out a redox reaction with this specific composition of bestowing in the tested corpse or other object for laboratory examination and chemical testing on biochip through ferment catalysis.This specific composition in the tested corpse or other object for laboratory examination and chemical testing that biochip of the present invention is measured is decided on the ferment composition that the biochip reaction layer comprises.For example, the redox mediators of biochip reaction layer is the potassium ferricyanide (potassium ferricyanide) and ferment composition when being glucose oxidase (glucoseoxidase), and this biochip can be in order to measure the concentration of glucose in the blood sample.Again, the redox mediators of biological example chip responding layer is the potassium ferricyanide (potassiumferricyanide) and ferment composition when being Lactate Oxidase (lactate oxidase), and this biochip can be in order to measure lactic acid (lactic acid) concentration in the saliva sample.
The spacing body of biochip of the present invention is positioned at the responding layer top, and this spacing body is provided with the end of a passage in the respective reaction layer.The cover plate of biochip is positioned at spacing body top, and this cover plate is provided with a passage top that is opened on spacing body, so that a tested corpse or other object for laboratory examination and chemical testing is inhaled into responding layer through opening and passage thus, with this responding layer dissolving, to carry out the redox reaction of a ferment catalysis.
Fig. 4 is the part control circuit synoptic diagram that the present invention includes a biological sensor of a biological chip and a main test cell, and wherein biochip itself has a resistance R
s, R wherein
sBe a value range, and serial connection one resistance value quite or approximately is slightly larger than maximum R
sThe resistance R of resistance value.When a tested corpse or other object for laboratory examination and chemical testing is bestowed on biochip, be inhaled into responding layer, after the responding layer dissolving, after a schedule time, the ferment catalytic oxidation-reduction reaction of the redox mediators of specific composition of this in the tested corpse or other object for laboratory examination and chemical testing and responding layer (redox mediator) is finished, the redox mediators that is reduced promptly becomes the electronics carrier, accumulates on the first end zone of biochip.Afterwards, an effect voltage V
Ref, for example can be by a battery supplied, bestow on the operation electrode of the first end of biochip, so that the redox mediators that is reduced disengages electronics, produce a kinetic current I through the operation electrode.This kinetic current I has one by one of biology sensor master test cell again and amplifies resistance R
fCurrent/voltage converter 40 convert an output voltage V to
OutMain test cell is again according to measured output voltage V
Out, to determine this specific components and concentration in the tested corpse or other object for laboratory examination and chemical testing.As shown in Figure 4, biochip of the present invention is serially connected with the resistance R that a resistance value quite or approximately is slightly larger than the maximum resistance of biochip own, can compensate the resistance value difference between each biochip, thereby reduce the noise ratio of each biochip, and then improve the measurement confidence level and the accuracy of measurement of each biochip.
Next, the present invention can improve the biochip of measuring confidence level, will be cooperated appended graphicly by following preferred embodiment, is described in detail.
Fig. 5 is the perspective diagram that is strip substrate 50 of the one biological chip of one first preferred embodiment according to the present invention.The first end 51 of substrate 50 has the counter electrode 512 that an operation electrode 511 and that is strip is strip, and a resistance R is serially connected with operation electrode 511.The second end 52 of substrate 50 has one first lead 521 and second lead 522.The operation electrode 511 of series resistor R and counter electrode 512 are from substrate 50 first ends 51 longitudinal extensions, with first lead 521 and second lead 522 that is electrically connected at the second end 52 respectively.The resistance value of resistance R quite or approximately is slightly larger than the maximum resistance of a resistance of operation electrode 511 and counter electrode 512 formation.Operation electrode 511 and counter electrode 512 can be formed by identical electric conductivity material, for example, and palladium (Pd), platinum (Pt), gold, silver, graphite, titanium and copper.Operation electrode 511, counter electrode 512, first lead 521 and second lead 522 can wire mark (screen printing) technology be formed on the substrate 50.
Fig. 6 is the perspective diagram that is strip substrate 60 of the one biological chip of one second preferred embodiment according to the present invention.The first end 61 of substrate 60 has a width increase and is the operation electrode 611 of strip and the counter electrode 612 that a width increase is strip, and the second end 62 of substrate 60 has one first lead 621 and one second lead 622.Operation electrode 611 and counter electrode 612 are from first lead 621 and second lead 622 of first end 61 longitudinal extensions to be electrically connected at the second end 62 respectively.The second preferred embodiment utilization of the present invention increases the width of operation electrode 611 and counter electrode 612 thereof, to increase the resistance value of biochip itself, promptly be equivalent to serial connection one resistance R on biochip, and by the width size of control operation electrode 611, to compensate resistance value difference between each biochip with its counter electrode 612.Operation electrode 611 and counter electrode 612 can have the same size size haply, and are formed by identical electric conductivity material, for example, and palladium (Pd), platinum (Pt), gold, silver, graphite, titanium and copper.Operation electrode 611, counter electrode 612, first lead 621 and second lead 622 can wire mark (screen printing) technology form on the submounts 60.
Fig. 7 is a perspective diagram that is strip substrate 70 of a biological chip of one the 3rd preferred embodiment according to the present invention.The first end 71 of substrate 70 has the counter electrode 712 that an operation electrode 711 and that is crooked strip is crooked strip.The second end 72 of substrate 70 has one first lead 721 and second lead 722.Operation electrode 711 and counter electrode 712 are from first end 71 longitudinal extensions, to be electrically connected at first lead 721 and second lead 722 respectively.The present invention's the 3rd preferred embodiment utilization increases the length of operation electrode 711 and counter electrode 712, for example do not increasing under the longitudinal length situation of substrate 71, formation is the operation electrode 711 and counter electrode 712 of crooked strip, to increase the resistance value of biochip itself, promptly be equivalent to serial connection one resistance R on biochip, and be crooked strip operation electrode 711 and the length that is crooked strip counter electrode 712 by control, to compensate resistance value difference between each biochip.Operation electrode 711 and counter electrode 712 can have the same size size haply, and are formed by identical electric conductivity material, for example, and palladium (Pd), platinum (Pt), gold, silver, graphite, titanium and copper.Operation electrode 711, counter electrode 712, first lead 721 and second lead 722 can wire mark (screen printing) technology be formed on the substrate 70.
According to above-mentioned preferred embodiment, the method that the present invention improves biochip measurement confidence level is that manufacture method is simple, can not increase the manufacturing step of additional complexity, can reach the purpose that reduces manufacturing cost.
The above is specific embodiments of the invention only, is not in order to limit protection scope of the present invention; All other do not break away from the equivalence of being finished under the disclosed spirit and changes or modification, all should be included in the scope of claims.
Claims (3)
1. one kind can be improved the biochip of measuring confidence level, it is characterized in that, comprising:
One substrate has a first end and a second end, and this first end has operation electrode and a corresponding electrode spaced apart from each other, and a resistance string is connected to this operation electrode, and this second end has one first lead and one second lead; Wherein this operation electrode and this counter electrode are formed with a maximum resistance R
s, and the resistance value that is serially connected with this resistance of this operation electrode is equivalent to this maximum resistance R
sThis operation electrode and this counter electrode are electrically connected at this first lead and this second lead respectively from this first end of this substrate, reach the main test cell that this first lead and this second lead are electrically connected at a biological sensor, this main test cell is used for measuring the kinetic current that this biochip corresponding one a tested corpse or other object for laboratory examination and chemical testing one specific composition produces in this operation electrode;
One responding layer, this first end top that is positioned at this substrate is to cover this operation electrode and this counter electrode, this responding layer comprises a redox mediators and a ferment, wherein this redox mediators with bestow that this specific composition carries out a redox reaction through this ferment catalysis in this tested corpse or other object for laboratory examination and chemical testing on this biochip;
One spacing body is positioned at this responding layer top, and this spacing body is provided with a passage in a end that mutually should responding layer; And
One cover plate is positioned at this spacing body top, and this cover plate is provided with one and is opened on above this passage of this spacing body, so that this tested corpse or other object for laboratory examination and chemical testing enters this responding layer via this opening and this passage.
2. the biochip of measuring confidence level that improves as claimed in claim 1 is characterized in that, this specific composition is decided on this ferment composition in this responding layer in measured this tested corpse or other object for laboratory examination and chemical testing of above-mentioned biochip.
3. one kind can be improved the chip substrate of measuring confidence level, it is characterized in that, comprising:
One base main body comprises a first end and a second end, and this first end has operation electrode and a corresponding electrode spaced apart from each other, and a resistance string is connected to this operation electrode, and this second end has one first lead and one second lead; Wherein this operation electrode and this counter electrode are formed with a maximum resistance R
s, and the resistance value that is serially connected with this resistance of this operation electrode is equivalent to this maximum resistance R
s, this operation electrode and this counter electrode are electrically connected at this first lead and this second lead respectively from this first end of this base main body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03101039 CN1256584C (en) | 2003-01-08 | 2003-01-08 | Biological chip capable of raising measurement reliability and its method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03101039 CN1256584C (en) | 2003-01-08 | 2003-01-08 | Biological chip capable of raising measurement reliability and its method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1515898A CN1515898A (en) | 2004-07-28 |
| CN1256584C true CN1256584C (en) | 2006-05-17 |
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ID=36761016
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03101039 Expired - Fee Related CN1256584C (en) | 2003-01-08 | 2003-01-08 | Biological chip capable of raising measurement reliability and its method |
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| CN (1) | CN1256584C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370249C (en) * | 2004-03-04 | 2008-02-20 | 五鼎生物技术股份有限公司 | Method for reducing measurement deviation of current type biosensors |
| CN103293191B (en) * | 2010-03-19 | 2015-07-29 | 瑞鼎科技股份有限公司 | Biochemistry detection unit and biochemical instrument thereof |
| KR101727446B1 (en) * | 2013-03-15 | 2017-04-14 | 에프. 호프만-라 로슈 아게 | Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same |
| CN113145183B (en) * | 2020-01-22 | 2022-12-06 | 京东方科技集团股份有限公司 | Biological chip and its making method |
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2003
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|---|---|
| CN1515898A (en) | 2004-07-28 |
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