CN1596991A - Sterilization bamboo fiber gauze and its preparation method and application - Google Patents
Sterilization bamboo fiber gauze and its preparation method and application Download PDFInfo
- Publication number
- CN1596991A CN1596991A CN 200410025791 CN200410025791A CN1596991A CN 1596991 A CN1596991 A CN 1596991A CN 200410025791 CN200410025791 CN 200410025791 CN 200410025791 A CN200410025791 A CN 200410025791A CN 1596991 A CN1596991 A CN 1596991A
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- CN
- China
- Prior art keywords
- sterilization
- bamboo fibre
- gauze
- original liquid
- fibre gauze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000017166 Bambusa arundinacea Nutrition 0.000 title claims abstract description 49
- 235000017491 Bambusa tulda Nutrition 0.000 title claims abstract description 49
- 241001330002 Bambuseae Species 0.000 title claims abstract description 49
- 235000015334 Phyllostachys viridis Nutrition 0.000 title claims abstract description 49
- 239000011425 bamboo Substances 0.000 title claims abstract description 49
- 239000000835 fiber Substances 0.000 title claims abstract description 49
- 230000001954 sterilising effect Effects 0.000 title claims description 52
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 49
- 238000002360 preparation method Methods 0.000 title description 5
- 239000007788 liquid Substances 0.000 claims abstract description 22
- 102000016943 Muramidase Human genes 0.000 claims description 16
- 108010014251 Muramidase Proteins 0.000 claims description 16
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 16
- 229960000274 lysozyme Drugs 0.000 claims description 16
- 235000010335 lysozyme Nutrition 0.000 claims description 16
- 239000004325 lysozyme Substances 0.000 claims description 16
- 241000191940 Staphylococcus Species 0.000 claims description 11
- 238000007598 dipping method Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 150000008040 ionic compounds Chemical class 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 6
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 229950009789 cetomacrogol 1000 Drugs 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000001103 potassium chloride Substances 0.000 claims description 3
- 235000011164 potassium chloride Nutrition 0.000 claims description 3
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 3
- 235000011009 potassium phosphates Nutrition 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 17
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 5
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000588923 Citrobacter Species 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 description 2
- TYMRLRRVMHJFTF-UHFFFAOYSA-N Mafenide Chemical compound NCC1=CC=C(S(N)(=O)=O)C=C1 TYMRLRRVMHJFTF-UHFFFAOYSA-N 0.000 description 2
- 229920001410 Microfiber Polymers 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229960003640 mafenide Drugs 0.000 description 2
- 239000003658 microfiber Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108090000988 Lysostaphin Proteins 0.000 description 1
- 101710132698 Lysozyme 3 Proteins 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 241000594182 Sarcophaga sigma Species 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Abstract
A bamboo fibre gauze able to kill bacteria is prepared through immersing the bamboo fibre gauze in the bactericiding liquid containing lysostaphinase and pharmacologically acceptable carrier.
Description
Technical field
The present invention relates to a kind of sterilization bamboo fibre gauze and its production and application, relate to a kind of bamboo fibre gauze that contains germicidal solution and its production and application specifically.
Background technology
Present Department of B urn, surgery, emergency room etc. clinically gauze commonly used generally has following several: common medical aseptic gauze, and both do not had antibiotic performance and do not had the resistance to bond energy yet, only do general wound wrapping; The resistance to bond gauze, the raw materials that adopt bamboo fibre as gauze more, can prevent the wound adhesion, but anti-microbial property is bad, as CN 1461827A disclosed " a kind of natural antibacterial material and uses thereof " and Japan Patent P2003-310721 " bamboo fibre system antibiotic property fabric "; The antibiotic property gauze, because of containing antibiotic substance, sterilizing function is arranged, can prevent or treat wound or traumatic infection, but do not solve the problem of resistance to bond, as CN 1360949A disclosed " bactericidal gauze with lysostaphin complex enzyme ", though the good sterilization performance is arranged, but but may adhesion be arranged, patient is caused suffering with wound surface.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of sterilization bamboo fibre gauze and its production and application, with the problem of bactericidal gauze meeting and wound surface adhesion in the solution prior art.
Sterilization bamboo fibre gauze of the present invention is characterized in that, this sterilization bamboo fibre gauze is to be prepared from wherein every 100cm by the method with dipping sterilization original liquid in the bamboo fibre gauze
2Four layers of bamboo fibre gauze in the sterilization original liquid of dipping 1-10ml, wherein, sterilization original liquid is to contain staphylococcus lysozyme that weight percent content is 0.001-1% and medically acceptable carrier is formed.
Preferred pickup is every 100cm
2Four layers of bamboo fibre gauze in the dipping 4-6ml sterilization original liquid.
The component of described sterilization original liquid and percentage by weight thereof are:
Staphylococcus lysozyme 0.001-1%
Lysozyme 0.1-20%
Protein stabilizing agent 0.2-50%
Ionic compound 0.5-10%
Water surplus
The preferred ingredients of sterilization original liquid and percentage by weight are:
Staphylococcus lysozyme 0.01-0.1%
Lysozyme 2-10%
Protein stabilizing agent 5-40%
Ionic compound 0.5-1%
Water surplus
Described protein stabilizing agent is one or more in chitosan, PEG400, cetomacrogol 1000, Macrogol 4000 or the polyethylene glycol 6000, and described ionic compound is one or more in sodium chloride, potassium chloride, potassium phosphate or the sodium phosphate.
The preparation method of sterilization bamboo fibre gauze of the present invention is characterized in that comprising the steps: the bamboo fibre gauze be impregnated in the sterilization original liquid, wherein every 100cm
2Four layers of bamboo fibre gauze in the dipping 1-10ml sterilization original liquid.
The present invention's bamboo fibre gauze that sterilizes can be used for wound surface external application dressing, or is used to prepare baby diaper, sanitary towel, mask etc.
Wherein used bamboo fibre gauze is by the NAFA LIFE LABORATORYCO. of Japan among the present invention, and LTD. company or Tianzhu Textile Fibers Co., Ltd. Shanghai provide.
The staphylococcus lysozyme that is adopted among the present invention is that Gaoke Bio-Engineering Co Ltd, Shanghai produces, or is bought by U.S. SIGMA company.
Sterilization bamboo fiber garn provided by the present invention is furnished with the good sterilization performance, external clinical common bacterial strain is carried out 5 minutes sterilization experiments (experimental technique was referring to 2002 the 4th edition " disinfection technology standard "), and data result is as follows:
| Strain | Sterilizing rate |
| Staphylococcus aureus (ATCC6538) | 100％ |
| Escherichia coli (8099) | 99.99％ |
| Candida albicans (ATCC10231) | 99.97％ |
| Bacillus pyocyaneus | 100％ |
Also adopt above-mentioned identical method to carry out 5 minutes sterilization experiments to two kinds of common endurance strains (staphylococcus aureus and bacillus pyocyaneus) of gathering clinically in addition, sterilizing rate is respectively 99.95% and 99.96%.
Simultaneously choose the patient that 20 examples have the wound surface bacterial infection, carry out clinical trial, observe the adhesive of sterilization bamboo fibre gauze respectively bactericidal effect and sterilization bamboo fibre gauze and the wound surface of traumatic infection bacterium at the Shanghai Changhai Hospital Department of B urn.The result is as follows:
Burn wound's more strain of distribution is methicillin-resistant staphylococcus (MRSA), bacillus pyocyaneus, klebsiella pneumoniae, acinetobacter calcoaceticus, citrobacter and Candida albicans, with the mafenide solution of common hospital gauze dipping 5% in contrast, before experiment, carry out the wound surface sampling after 72 hours with deposited gauze, and do the antibacterial cultivation, sterilizing rate before and after the comparative experiments
Bacterial species matched group use group
MRSA????????????????????63.67????????????????100.00
Bacillus pyocyaneus 79.58 99.81
Klebsiella pneumoniae 66.05 100.00
Citrobacter 58.46 92.45
Acinetobacter calcoaceticus 60.35 99.85
This shows that the bactericidal effect of the sterilization bamboo fibre gauze of the present invention mafenide gauze that Department of B urn is commonly used at present will be got well.
The inventor finds, because bamboo fibre and cotton fiber are constructional different, cotton fiber is a hollow, and bamboo fibre has groove, there is a lot of microfibres on the bamboo fibre surface, cotton fiber is to absorb moisture by hollow space, bamboo fibre then is the trench portions absorption moisture by the surface, add that again the microfibre on bamboo fibre surface and the moisture that trench portions absorbs just in time become " buffer agent " between skin and the gauze, therefore, bamboo fibre can play the effect of tissue adhesion, so sterilization bamboo fibre gauze of the present invention can alleviate the misery of patient when changing dressings, and helps the healing of wound surface.The present invention compares with adhesive wound surface two kinds of gauzes simultaneously, wound surface that find to use common hospital gauze has in various degree pain per capita changing the gauze seasonal disease, and can make part trend or the position of healing is destroyed again, be unfavorable for the healing of wound surface.And sterilization bamboo fibre gauze is because the property of bamboo fibre, gauze not with the wound surface adhesion, not only can patient not caused suffering, and can obviously shorten the time of wound healing.
And in the clinical observation process, find no any other untoward reaction and take place, not only good effect of sterilization bamboo fibre gauze of the present invention is described, and, can be widely used in clinical toxic and side effects such as patient's nonirritants.
The specific embodiment
Embodiment 1
Staphylococcus lysozyme 0.001 gram
Lysozyme 3 grams
Chitosan 10 grams
Sodium chloride 0.9 gram
Water surplus
Preparation 100ml sterilization original liquid, four layers of bamboo fibre gauze of 14cm*7cm be impregnated in the sterilization original liquid of 5ml, can be used for the section office that Department of B urn, surgery, department of obstetrics and gynecology, speciality of carbuncle and ulcers etc. have surface wound, as wound surface prevention or treatment antibacterial and fungal infection, promote wound healing, reduce the course of treatment.
Embodiment 2
Staphylococcus lysozyme 0.1 gram
Lysozyme 10 grams
Chitosan 5 grams
Cetomacrogol 1000 2 grams
Potassium chloride 1 gram
Water surplus
Preparation l00ml sterilization original liquid impregnated in four layers of bamboo fibre gauze of 14cm*7cm in the sterilization original liquid of 2ml, is used for baby diaper, as prevention baby antibacterial and fungal infection.
Embodiment 3
Staphylococcus lysozyme 0.01 gram
Lysozyme 8 grams
Cetomacrogol 1000 6 grams
Potassium phosphate 0.7 gram
Water surplus
Preparation 100ml sterilization original liquid impregnated in four layers of bamboo fibre gauze of 14cm*7cm in the sterilization original liquid of 4ml, can be used for the sanitary towel that the women uses, the prevention vaginal infection.
Claims (9)
1. a sterilization bamboo fibre gauze is characterized in that wherein every 100cm
2Four layers of bamboo fibre gauze in the sterilization original liquid of dipping 1-10ml, sterilization original liquid is to contain staphylococcus lysozyme that weight percent content is 0.001-1% and medically acceptable carrier is formed.
2. sterilization bamboo fibre gauze according to claim 1 is characterized in that every 100cm
2Four layers of bamboo fibre gauze in the dipping 4-6ml sterilization original liquid.
3. sterilization bamboo fibre gauze according to claim 1 is characterized in that the component of described sterilization original liquid and percentage by weight thereof are:
Staphylococcus lysozyme 0.001-1%
Lysozyme 0.1-20%
Protein stabilizing agent 0.2-50%
Ionic compound 0.5-10%
Water surplus.
4. sterilization bamboo fibre gauze according to claim 3 is characterized in that the preferred ingredients of sterilization original liquid and percentage by weight are:
Staphylococcus lysozyme 0.01-0.1%
Lysozyme 2-10%
Protein stabilizing agent 5-40%
Ionic compound 0.5-1%
Water surplus.
5. sterilization bamboo fibre gauze according to claim 3 is characterized in that described protein stabilizing agent is one or more in chitosan, PEG400, cetomacrogol 1000, Macrogol 4000 or the polyethylene glycol 6000.
6. according to claim 3 or 5 described sterilization bamboo fibre gauzes, it is characterized in that described ionic compound is one or more in sodium chloride, potassium chloride, potassium phosphate or the sodium phosphate.
7. prepare the method for the described sterilization bamboo fibre of claim 1 gauze, it is characterized in that, comprise the steps: the bamboo fibre gauze be impregnated in the sterilization original liquid, wherein every 100cm
2Four layers of bamboo fibre gauze in the dipping 1-10ml sterilization original liquid.
8. each described sterilization bamboo fibre gauze of claim 1～4 is used for wound surface external application dressing.
9. each described sterilization bamboo fibre gauze of claim 1～4 is used to prepare baby diaper, sanitary towel or mask.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410025791 CN1596991B (en) | 2004-07-06 | 2004-07-06 | Sterilization bamboo fiber gauze and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410025791 CN1596991B (en) | 2004-07-06 | 2004-07-06 | Sterilization bamboo fiber gauze and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1596991A true CN1596991A (en) | 2005-03-23 |
| CN1596991B CN1596991B (en) | 2012-08-08 |
Family
ID=34663854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410025791 Expired - Lifetime CN1596991B (en) | 2004-07-06 | 2004-07-06 | Sterilization bamboo fiber gauze and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1596991B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285417A (en) * | 2013-06-08 | 2013-09-11 | 安吉天威医疗用品有限公司 | Bamboo fiber bandage |
| CN104524622A (en) * | 2014-12-11 | 2015-04-22 | 杨陈 | Lysostaphin compound enzyme sterile gauze and preparation method thereof |
| CN106540305A (en) * | 2015-09-17 | 2017-03-29 | 珠海和凡医药股份有限公司 | A kind of preparation of Kaolin bamboo fibre gauze and its new application |
| CN107625990A (en) * | 2016-07-19 | 2018-01-26 | 黄青山 | Composite with antibacterial functions and the application in paper diaper for infant is prepared |
| CN108096625A (en) * | 2017-12-14 | 2018-06-01 | 傅婵 | Antibiotic health care protection pad |
| CN108703420A (en) * | 2018-06-25 | 2018-10-26 | 陈承基 | A kind of female mammary gland health-care brassiere Chinese medicine protection pad and preparation method thereof |
| CN118370654A (en) * | 2024-06-25 | 2024-07-23 | 浙江夕尔科技有限公司 | Method for preparing sanitary cotton sliver and antibacterial fiber |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1157230C (en) * | 2000-12-28 | 2004-07-14 | 上海高科生物工程有限公司 | Bactericidal gauze with lysostaphin complex enzyme |
| CN1209972C (en) * | 2002-09-28 | 2005-07-13 | 上海高科联合生物技术研发有限公司 | Sterilization formulation and wet tissue, preparation method and use |
| CN1446515A (en) * | 2003-03-03 | 2003-10-08 | 上海天竹纺织纤维有限公司 | Dishcloth with natural bactericidal action |
-
2004
- 2004-07-06 CN CN 200410025791 patent/CN1596991B/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285417A (en) * | 2013-06-08 | 2013-09-11 | 安吉天威医疗用品有限公司 | Bamboo fiber bandage |
| CN103285417B (en) * | 2013-06-08 | 2014-09-24 | 安吉天威医疗用品有限公司 | Bamboo fiber bandage |
| CN104524622A (en) * | 2014-12-11 | 2015-04-22 | 杨陈 | Lysostaphin compound enzyme sterile gauze and preparation method thereof |
| CN106540305A (en) * | 2015-09-17 | 2017-03-29 | 珠海和凡医药股份有限公司 | A kind of preparation of Kaolin bamboo fibre gauze and its new application |
| CN107625990A (en) * | 2016-07-19 | 2018-01-26 | 黄青山 | Composite with antibacterial functions and the application in paper diaper for infant is prepared |
| CN108096625A (en) * | 2017-12-14 | 2018-06-01 | 傅婵 | Antibiotic health care protection pad |
| CN108703420A (en) * | 2018-06-25 | 2018-10-26 | 陈承基 | A kind of female mammary gland health-care brassiere Chinese medicine protection pad and preparation method thereof |
| CN118370654A (en) * | 2024-06-25 | 2024-07-23 | 浙江夕尔科技有限公司 | Method for preparing sanitary cotton sliver and antibacterial fiber |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1596991B (en) | 2012-08-08 |
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Granted publication date: 20120808 |