CN1586589A - Ginseng stem and leaf total saponin oral disintegration tablet and its preparing method - Google Patents
Ginseng stem and leaf total saponin oral disintegration tablet and its preparing method Download PDFInfo
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- CN1586589A CN1586589A CN 200410069353 CN200410069353A CN1586589A CN 1586589 A CN1586589 A CN 1586589A CN 200410069353 CN200410069353 CN 200410069353 CN 200410069353 A CN200410069353 A CN 200410069353A CN 1586589 A CN1586589 A CN 1586589A
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- stem
- leaf
- radix ginseng
- total saponins
- essence
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Abstract
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Claims (8)
- One kind can the spleen invigorating QI invigorating, be used for the cardiopalmus that the deficiency of vital energy causes, breathe hard, fatigue and weak, the indigestion and loss of appetite ginseng stem and leaf total saponin oral disintegrating tablet that waits card, by stem and leaf of Radix Ginseng total saponins, filler, disintegrating agent, correctives, fluidizer, supplementary materials such as lubricant, according to circumstances can also add binding agent, effervescent or coating material, with suitable proportioning, form through specific method for preparing, it is characterized in that its prescription is composed as follows: stem and leaf of Radix Ginseng total saponins (5-50) %, binding agent (0-5) %, filler (10-80) %, disintegrating agent (2-35) %, correctives (1-40) %, coating material (0-40) %, effervescent (0-30) %, fluidizer (0.01-5) %, lubricant (0.3-3) %.
- 2. various adjuvants of addressing according to claim 1 of being addressed is characterized in that selection kind separately is as follows:Binding agent---include but are not limited to starch, pregelatinized Starch, dextrin, maltodextrin, sucrose, arabic gum, gelatin, methylcellulose, carboxymethyl cellulose, ethyl cellulose, polyvinyl alcohol, Polyethylene Glycol, polyvinylpyrrolidone (PVP), alginic acid and alginate, xanthan gum, hydroxypropyl cellulose and hydroxypropyl emthylcellulose (HPMC), can use use also capable of being combined separately.Filler---include but are not limited to mannitol (granular or powdery), xylitol, sorbitol, maltose, Chi ?alcohol, microcrystalline Cellulose, PROSOLV SMCC, polymerization sugar (EMDEX ), coupling sugar, glucose, lactose, sucrose, dextrin and starch etc., can use separately, also can applied in any combination, consumption is generally (10-80) %.Disintegrating agent---include but are not limited to crospolyvinylpyrrolidone (PVPP), carboxymethyl starch sodium (CMS-Na), low substituted hydroxy-propyl methylcellulose (L-HPC), cross-linking sodium carboxymethyl cellulose (CCNa) and soybean polysaccharide (EMCOSOY ) etc., can use use also capable of being combined separately.Correctives---include but are not limited to mannitol, xylitol, stevioside, lactose, fructose, sucrose, protein sugar, maltose alcohol, glycyrrhizin, Sodium Cyclamate, gelatin, aspartame, flavoring banana essence, flavoring pineapple essence, vanillin, fragrant citrus essence, flavoring orange essence, Herba Menthae essence, ginseng essence, strawberry essence, citric acid, citric acid etc., can use use also capable of being combined separately.Coating material---include but are not limited to gelatin, arabic gum, alginate, chitosan, carboxymethyl cellulose salt, cellulose acetate phthalate ester, ethyl cellulose, methylcellulose, hypromellose, crylic acid resin (homemade acrylic resin I, II, III, IV, Eudragit Series), polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene Glycol etc., can use use also capable of being combined separately.Fluidizer---include but are not limited to micropowder silica gel, Pulvis Talci, Cab-O-sil, Arosil, hydrated sodium aluminosilicate etc., can use use also capable of being combined separately.Lubricant---include but are not limited to magnesium stearate, calcium stearate, zinc stearate, glyceryl monostearate, Polyethylene Glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyethylene monostearate, single Laurel sucrose acid ester, sodium laurylsulfate, magnesium laurylsulfate, Stepanol MG and Pulvis Talci etc., can use use also capable of being combined separately.
- 3. preparation method that is used for the ginseng stem and leaf total saponin oral disintegrating tablet that claim 1 addresses is characterized in that being made up of following steps:The pretreatment of first step stem and leaf of Radix Ginseng total saponins:(1) directly flavoring---this law is granulated to the stem and leaf of Radix Ginseng total saponins raw material or is not dealt with, and directly enters for second step;(2) powder coating taste masking---get selected coating material, with the dissolving of the solvent that adapts with it and to be diluted to debita spissitudo standby, getting stem and leaf of Radix Ginseng total saponins again places ebullated bed to make boiling, spray into above-mentioned solution with suitable speed then and carry out powder coating, get stem and leaf of Radix Ginseng total saponins powder coating granule, dry back sieving for standby;Second step took by weighing correctives and stem and leaf of Radix Ginseng total saponins or the feed particles after first step taste masking processing according to quantity, and mix homogeneously is standby;The 3rd step took by weighing filler, disintegrating agent, effervescent, fluidizer and mix homogeneously according to quantity, made evenly again with through second mixing of materials that goes on foot gained, and adding lubricant mixing is standby;The 4th step gained material detects through intermediate, determine that sheet is heavy after, send into the tablet machine tabletting promptly.
- 4. the preparation method of addressing according to claim 3 is characterized in that: the method for the first step (2) need be used coating material that stem and leaf of Radix Ginseng total saponins is carried out taste masking in advance and handle.
- 5. the preparation method of addressing according to claim 4, it is characterized in that: be used for coating material that taste masking handles and be any one or two or more mixture such as gelatin, arabic gum, alginate, chitosan, carboxymethyl cellulose salt, cellulose acetate phthalate ester, ethyl cellulose, methylcellulose, hypromellose, crylic acid resin (homemade acrylic resin I, II, III, IV, Eudragit series), polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene Glycol.
- 6. any preparation method of addressing according to claim 3 is characterized in that: according to circumstances also can add the adjuvant effervescent.
- 7. the effervescent of addressing according to claim 6, it is characterized in that: this adjuvant is the mixture of malic acid, citric acid or citric acid and sodium bicarbonate or sodium carbonate.
- 8. preparation method that is used for the ginseng stem and leaf total saponin oral disintegrating tablet that claim 1 addresses, the hardness that it is characterized in that the tablet that obtains are between 10 to 45 newton, and disintegration time is at 1-60 in second.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200410069353 CN1283267C (en) | 2004-07-19 | 2004-07-19 | Ginseng stem and leaf total saponin oral disintegration tablet and its preparing method |
Applications Claiming Priority (1)
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CN 200410069353 CN1283267C (en) | 2004-07-19 | 2004-07-19 | Ginseng stem and leaf total saponin oral disintegration tablet and its preparing method |
Publications (2)
Publication Number | Publication Date |
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CN1586589A true CN1586589A (en) | 2005-03-02 |
CN1283267C CN1283267C (en) | 2006-11-08 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 200410069353 Expired - Fee Related CN1283267C (en) | 2004-07-19 | 2004-07-19 | Ginseng stem and leaf total saponin oral disintegration tablet and its preparing method |
Country Status (1)
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CN (1) | CN1283267C (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007006208A1 (en) * | 2005-07-14 | 2007-01-18 | National Institute Of Pharmaceutical R & D Co., Ltd. | Medicinal composition containing ginseng secondary glycosides, its preparation method and application |
CN100387226C (en) * | 2005-03-18 | 2008-05-14 | 北京科信必成医药科技发展有限公司 | Cepharanthine oral disintegration tablet and its preparing method |
CN102948418A (en) * | 2011-08-26 | 2013-03-06 | 浙江海洋学院 | Tea saponin tablet and preparation method thereof |
CN106943440A (en) * | 2017-04-10 | 2017-07-14 | 高其品 | The sorbefacient of polyose medicament bioavilability can be improved |
-
2004
- 2004-07-19 CN CN 200410069353 patent/CN1283267C/en not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100387226C (en) * | 2005-03-18 | 2008-05-14 | 北京科信必成医药科技发展有限公司 | Cepharanthine oral disintegration tablet and its preparing method |
WO2007006208A1 (en) * | 2005-07-14 | 2007-01-18 | National Institute Of Pharmaceutical R & D Co., Ltd. | Medicinal composition containing ginseng secondary glycosides, its preparation method and application |
US7973014B2 (en) | 2005-07-14 | 2011-07-05 | National Institute Of Pharmaceutical R&D Co., Ltd. | Medicinal composition containing ginseng secondary glycosides, its preparation method and application |
CN102948418A (en) * | 2011-08-26 | 2013-03-06 | 浙江海洋学院 | Tea saponin tablet and preparation method thereof |
CN102948418B (en) * | 2011-08-26 | 2015-10-21 | 浙江海洋学院 | A kind of tea saponin tablet and preparation method thereof |
CN106943440A (en) * | 2017-04-10 | 2017-07-14 | 高其品 | The sorbefacient of polyose medicament bioavilability can be improved |
Also Published As
Publication number | Publication date |
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CN1283267C (en) | 2006-11-08 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CI01 | Publication of corrected invention patent application |
Correction item: Denomination of Invention Correct: Ginseng stem and leaf total saponin oral disintegrating tablet preparation and preparation process thereof False: Ginseng stem and leaf total saponin oral disintegrating tablet preparation and preparation method thereof Number: 45 Page: 920 Volume: 22 |
|
CI03 | Correction of invention patent |
Correction item: Denomination of Invention Correct: Ginseng stem and leaf total saponin oral disintegrating tablet preparation and preparation process thereof False: Ginseng stem and leaf total saponin oral disintegrating tablet preparation and preparation method thereof Number: 45 Page: The title page Volume: 22 |
|
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 100083 Haidian District, Xueyuan Road, No. 30, A building, room No. 15, room, room 15 Patentee after: COSCI MED-TECH Co.,Ltd. Address before: 100080, Haidian District satellite building, No. 63, Zhichun Road, Beijing, room 1410, Beijing Patentee before: COSCI MED-TECH Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061108 |