CN1297263C - Calcium gluconate oral disintegrating tablet and its preparation process - Google Patents
Calcium gluconate oral disintegrating tablet and its preparation process Download PDFInfo
- Publication number
- CN1297263C CN1297263C CNB200410086320XA CN200410086320A CN1297263C CN 1297263 C CN1297263 C CN 1297263C CN B200410086320X A CNB200410086320X A CN B200410086320XA CN 200410086320 A CN200410086320 A CN 200410086320A CN 1297263 C CN1297263 C CN 1297263C
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- CN
- China
- Prior art keywords
- calcium gluconate
- disintegrating tablet
- essence
- sodium
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000004227 calcium gluconate Substances 0.000 title claims abstract description 41
- 229960004494 calcium gluconate Drugs 0.000 title claims abstract description 41
- 235000013927 calcium gluconate Nutrition 0.000 title claims abstract description 37
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000011248 coating agent Substances 0.000 claims abstract description 20
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- 206010006956 Calcium deficiency Diseases 0.000 claims abstract description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 28
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 17
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- 230000001070 adhesive effect Effects 0.000 abstract 1
- 239000004067 bulking agent Substances 0.000 abstract 1
- 238000003860 storage Methods 0.000 abstract 1
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- 239000002552 dosage form Substances 0.000 description 6
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- 238000001514 detection method Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
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- 239000000243 solution Substances 0.000 description 3
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
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- 208000019505 Deglutition disease Diseases 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
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- 159000000007 calcium salts Chemical class 0.000 description 1
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- 230000007812 deficiency Effects 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a calcium gluconate orally disintegrating tablet for preventing and treating calcium deficiency and a preparation process thereof. The preparation method comprises: using calcium gluconate as raw material and bulking agents, disintegrating agents, corrigents, glidants and lubricating agents as auxiliary materials; using adhesives or coating materials or adding proper quantity of effervescent agents according to different situations; preparing the present invention through a specific preparation method and obtaining final tablets after tabletting by tabletting machines. The orally disintegrating tablet of the present invention has the characteristics of good friability, rapid disintegration, good taste, no gravel feel, no need of specific production condition, low production cost, convenient carry, storage transportation and use, etc.; the orally disintegrating tablet can be taken without water in particular and take reaction quickly, and therefore, the present invention improves the patient's compliance and enhances the curative effect of the medicine.
Description
Technical field
The present invention relates to a kind of calcium gluconate oral disintegrating tablet preparation that is used to prevent and treat calcium deficiency.
Background technology
Can promote the calcification of skeleton and tooth, keep the neuromuscular NE, reduce capillary permeability, increase the contractility of capillary wall.The clinical calcium salt that is used to prevent and treat calcium deficiency such as tetany, dysosteogenesis, rickets and tuberculosis, gestation and women breast-feeding their children replenishes.
The dosage form of existing gluconic acid calcium preparation has: injection, oral liquid and ordinary tablet etc.
Because dosage form, ordinary tablet need a large amount of water to send down when taking, this makes the patient of many old peoples, infant or dysphagia, water intaking inconvenience be difficult to take, and old people and infant are the crowds that need replenish the calcium.Oral liquid carries inconvenience, and injection often is easy to generate anaphylaxis or untoward reaction etc. again, and it is big that the while injection also exists operation easier, and the patient suffering is also big, makes and medical treatment cost high the shortcoming that patient economy burden is heavy.Therefore, be necessary to prepare and take convenient dosage form to satisfy the multiple needs that clinical treatment and family use.
Summary of the invention
The objective of the invention is to improve the deficiency of existing calcium gluconate aspect peroral dosage form, provide a kind of taking convenience, absorption is rapid-action, bioavailability is high calcium gluconate oral disintegrating tablet preparation to extensive patients and medical personnel.Needn't drink water when the present invention relates to take, in the oral cavity, only need get final product rapid disintegrate or dissolving in tens seconds, can finish calcium gluconate oral disintegrating tablet of taking medicine and preparation method thereof with saliva hypopharynx.
One, prescription
The calcium gluconate oral disintegrating tablet that reaches of the present invention comprises the material medicine calcium gluconate, needs following former, the auxiliary material of 9 classes altogether, and wherein: when not making Cotton seeds, then do not use coating material, effervescent also can for selecting adjuvant for use as one sees fit.
Calcium gluconate (5-60) %, binding agent (0-5) %, filler (10-80) %, disintegrating agent (2-35) %, correctives (1-40) %, coating material (0-40) %, effervescent (0-30) %, fluidizer (0.01-5) %, lubricant (0.3-3) %.
As one of embodiment, carry out Cotton seeds, described coating material is a crylic acid resin, and coating material is no more than 40%, calcium gluconate makes calcium gluconate powder coated granule by powder coating, makes disintegrating tablet with other component mixing, tabletting again.Wherein, described crylic acid resin can be selected from homemade acrylic resin I, II, III or IV, perhaps Eudragit
Series, for example Eudragit
E100.
Wherein:
Binding agent includes but are not limited to starch, pregelatinized Starch, dextrin, maltodextrin, sucrose, arabic gum, gelatin, methylcellulose, carboxymethyl cellulose, ethyl cellulose, polyvinyl alcohol, Polyethylene Glycol, polyvinylpyrrolidone (PVP), alginic acid and alginate, xanthan gum, hydroxypropyl cellulose and hydroxypropyl emthylcellulose (HPMC), can use use also capable of being combined separately.
Filler include but are not limited to mannitol (granular or powdery), xylitol, sorbitol, maltose, Chi ?alcohol, microcrystalline Cellulose, PROSOLV
SMCC, polymerization sugar (EMDEX
), coupling sugar, glucose, lactose, sucrose, dextrin and starch etc., can use separately, also can applied in any combination, consumption is generally (10-80) %.
Disintegrating agent includes but are not limited to crospolyvinylpyrrolidone (PVPP), carboxymethyl starch sodium (CMS-Na), low substituted hydroxy-propyl methylcellulose (L-HPC), cross-linking sodium carboxymethyl cellulose (CCNa) and soybean polysaccharide (EMCOSOY
) etc., can use use also capable of being combined separately.
Correctives includes but are not limited to mannitol, xylitol, stevioside, lactose, fructose, sucrose, protein sugar, maltose alcohol, glycyrrhizin, Sodium Cyclamate, gelatin, aspartame, flavoring banana essence, flavoring pineapple essence, vanillin, fragrant citrus essence, flavoring orange essence, Herba Menthae essence, ginseng essence, strawberry essence, citric acid, citric acid etc., can use use also capable of being combined separately.
Coating material includes but are not limited to gelatin, arabic gum, alginate, chitosan, carboxymethyl cellulose salt, cellulose acetate phthalate ester, ethyl cellulose, methylcellulose, hypromellose, crylic acid resin (homemade acrylic resin I, II, III, IV, Eudragit
Series), polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene Glycol etc., can use use also capable of being combined separately.
Fluidizer includes but are not limited to micropowder silica gel, Pulvis Talci, Cab-O-sil, Arosil, hydrated sodium aluminosilicate etc., can use use also capable of being combined separately.
Lubricant includes but are not limited to magnesium stearate, calcium stearate, zinc stearate, glyceryl monostearate, Polyethylene Glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyethylene monostearate, single Laurel sucrose acid ester, sodium laurylsulfate, magnesium laurylsulfate, Stepanol MG and Pulvis Talci etc., can use use also capable of being combined separately.
Effervescent includes but are not limited to the mixture of malic acid, citric acid or citric acid and sodium bicarbonate or sodium carbonate.
Two, preparation method
The calcium gluconate oral disintegrating tablet that reaches of the present invention, its preparation method is a direct compression process, the manufacturer with preparation conventional tablet all can adopt.
The calcium gluconate odorless, tasteless.The present invention is flavoring or taste masking not; Also can adopt two kinds of distinct methods to carry out flavoring or taste masking: 1. to adopt the direct flavoring of correctives; 2. in advance calcium gluconate is carried out powder coating with taste masking.
Concrete preparation method is as follows:
The preprocess method of first step calcium gluconate:
1. directly the flavoring method---this law is granulated to the calcium gluconate raw material or is not dealt with, and directly enters for second step;
2. powder coating taste masking---get selected coating material, with the dissolving of the solvent that adapts with it and to be diluted to debita spissitudo standby, getting calcium gluconate again places ebullated bed to make boiling, spray into above-mentioned solution with suitable speed then and carry out powder coating, get calcium gluconate powder coated granule, dry back sieving for standby;
Second step took by weighing correctives and calcium gluconate or the feed particles after first step taste masking processing according to quantity, and mix homogeneously is standby;
The 3rd step took by weighing filler, disintegrating agent, effervescent, fluidizer and mix homogeneously according to quantity, made evenly again with through second mixing of materials that goes on foot gained, and adding lubricant mixing is standby;
The 4th step gained material detects through intermediate, determine that sheet is heavy after, send into the tablet machine tabletting promptly.
The tablet that above-mentioned preparation method obtained, its hardness are between 10 to 45 newton, and disintegration time is at 1-60 in second.
Beneficial effect
Tablet is a kind of conventional dosage forms, because of its steady quality, dosage accurately, take, easy to carry, mechanization degree is high, low one of the at present the most frequently used dosage form that becomes of production cost, but because of the tablet extrusion forming, disintegrate is slow, bioavailability is lower, and part patient swallows comparatively difficult, thereby promoting the use of to a certain extent of tablet is restricted.The oral administration solid quick releasing formulation becomes a focus, particularly oral cavity disintegration tablet of new drug development in recent years for this reason, because of its taking convenience, rapid-action, bioavailability is high, the good emphasis that becomes tablet exploitation of mouthfeel.
Oral cavity disintegration tablet is meant not to be needed water or only needs low amounts of water, need not to chew, and tablet places lingual surface, disintegrate rapidly after the chance saliva, or borrow and swallow power, medicine can be gone into the tablet of stomach onset.The characteristics of oral cavity disintegration tablet are that absorption is fast, bioavailability is high, and intestinal is residual few, and side effect is low, avoids liver first-pass effect etc.
According to the requirement of " formulation characteristic of oral cavity disintegration tablet and quality control meeting summary ", oral cavity disintegration tablet has essential leap than the disintegration rate of drop pill and ordinary tablet, and the disintegrate of oral cavity disintegration tablet generally in 30 seconds, is no more than 1 minute at most.
Specific embodiment
Embodiment one
(1) prescription
1. raw material---calcium gluconate 100.0g;
2. filler---mannitol 100.0g;
PROSOLV
SMCC 35.0g；
3. disintegrating agent---cross-linking sodium carboxymethyl cellulose 10.0g;
4. fluidizer---micropowder silica gel 2.5g;
5. lubricant---magnesium stearate 2.5g.
Gross weight 250.0g makes 1000 altogether.
(2) preparation method
1) get the calcium gluconate raw material pulverizing, sieve, it is standby to get 80 order to 40 purpose powders;
2) with the calcium gluconate and the PROSOLV of step 1)
The SMCC mix homogeneously, standby;
3) get mannitol (granular) and cross-linking sodium carboxymethyl cellulose mix homogeneously;
4) with micropowder silica gel and magnesium stearate mix homogeneously, add step 2 again) and the material of step 3), mix homogeneously;
5) intermediate content detection, determine that sheet is heavy after, send into the tablet machine tabletting promptly.
Embodiment two
(1) prescription
1. raw material---calcium gluconate 500.0g;
2. binding agent---polyvinylpyrrolidone K-30 3.0g;
3. filler---mannitol 200.0g;
Microcrystalline Cellulose 100.0g;
4. correctives---aspartame 9.0g;
Fragrant citrus essence 18.0g;
5. disintegrating agent---crospolyvinylpyrrolidone 20.0g;
Cross-linked carboxymethyl cellulose 34.0g;
6. fluidizer---micropowder silica gel 8.0g;
7. lubricant---magnesium stearate 8.0g.
Gross weight 900.0g makes 1000 altogether.
(2) preparation method
1) gets polyvinylpyrrolidone K-30 with 50% dissolve with ethanol and to be diluted to finite concentration standby;
2) getting calcium gluconate and microcrystalline Cellulose and granulate with the mixed at high speed mixer granulator, is binding agent with the solution of step 1), and dry back is standby;
3) with mannitol, micropowder silica gel, crospolyvinylpyrrolidone, cross-linked carboxymethyl cellulose, aspartame and fragrant citrus essence mix homogeneously, again with step 2) granule mixed evenly, standby;
4) carry out the intermediate content detection, determine that sheet is heavy;
5) add magnesium stearate, mixing is sent into the tablet machine tabletting promptly.
Embodiment three
(1) prescription
1. raw material---calcium gluconate 150.0g;
2. coating material---Eudragit
E100 15.0g;
3. filler---polymerization sugar 175.0g;
4. correctives---aspartame 4.0g;
Flavoring orange essence 8.0g;
5. disintegrating agent---crospolyvinylpyrrolidone 26.0g;
Low substituted hydroxy-propyl methylcellulose 14.0g;
6. fluidizer---micropowder silica gel 4.0g;
7. lubricant---magnesium stearate 4.0g.
Gross weight 400.0g makes 1000 altogether.
(3) preparation method
1) gets Eudragit
E100 is with the medicinal alcohol more than 95% dissolving and to be diluted to finite concentration standby;
2) get calcium gluconate and place ebullated bed to seethe with excitement, spray into above-mentioned solution by certain speed and carry out powder coating, make calcium gluconate powder coated granule, dry back is standby;
3), standby with the coated granule mixing again with polymerization sugar, micropowder silica gel, crospolyvinylpyrrolidone, low substituted hydroxy-propyl methylcellulose, aspartame and flavoring orange essence mix homogeneously;
4) intermediate content detection determines that sheet is heavy;
5) add magnesium stearate, mixing is sent into the tablet machine tabletting promptly.
Embodiment four
(1) prescription
1. raw material---calcium gluconate 200.0g;
2. binding agent---polyvinylpyrrolidone K-30 2.0g;
3. effervescent---citric acid 35.0g;
Sodium bicarbonate 30.0g;
4. filler---mannitol 128.0g;
PROSOLV
SMCC 50.0g；
5. correctives---aspartame 5.0g;
Fragrant citrus essence 10.0g;
6. disintegrating agent---crospolyvinylpyrrolidone 12.0g;
Exchange carboxymethyl cellulose 18.0g;
7. fluidizer---micropowder silica gel 5.0g;
8. lubricant---sodium stearyl fumarate 5.0g.
Gross weight 500g makes 1000 altogether.
(3) preparation method
1) get calcium gluconate and citric acid raw material and mix the back pulverizing, granulate, cross 26 mesh sieves with polyvinylpyrrolidone K-30, standby;
2) get sodium bicarbonate and pulverize, granulate, cross 26 mesh sieves with polyvinylpyrrolidone K-30, standby;
3) will be except that magnesium stearate all the other all adjuvants cross mix homogeneously behind 40 mesh sieves respectively, add the granule 1 of having granulated again) and 2), mix homogeneously, standby;
4) intermediate content detection, determine that sheet is heavy after;
5) add magnesium stearate, mixing is sent into the tablet machine tabletting promptly.
Claims (6)
1. calcium gluconate oral disintegrating tablet that is used to prevent or treat calcium deficiency, by calcium gluconate, filler, disintegrating agent, correctives, fluidizer, lubricant, coating material and the optional binding agent that exists, the optional effervescent that exists, with suitable proportioning, form through specific method for preparing, it is characterized in that: described proportioning is for to calculate with weight percentage, calcium gluconate 5%～60%, filler 10%～80%, disintegrating agent 2%～35%, correctives 1%～40%, fluidizer 0.01%～5%, lubricant 0.3%～3%, coating material is no more than 40%, binding agent 0～5%, effervescent 0～30%, described coating material are crylic acid resin, and described method is that calcium gluconate makes calcium gluconate powder coated granule by powder coating, again with other component mixing, tabletting makes disintegrating tablet.
2. calcium gluconate oral disintegrating tablet according to claim 1 is characterized in that:
Described binding agent is selected from one or more in starch, pregelatinized Starch, dextrin, maltodextrin, sucrose, arabic gum, gelatin, methylcellulose, carboxymethyl cellulose, ethyl cellulose, polyvinyl alcohol, Polyethylene Glycol, polyvinylpyrrolidone, alginic acid or alginate, xanthan gum, hydroxypropyl cellulose and the hydroxypropyl emthylcellulose;
Described filler be selected from mannitol, xylitol, sorbitol, maltose, Chi ?alcohol, microcrystalline Cellulose, PROSOLV
In SMCC, coupling sugar, glucose, lactose, sucrose, dextrin and the starch one or more;
Described disintegrating agent is selected from one or more in crospolyvinylpyrrolidone, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose, cross-linking sodium carboxymethyl cellulose and the soybean polysaccharide;
Described correctives is selected from one or more in mannitol, xylitol, stevioside, lactose, fructose, sucrose, protein sugar, maltose alcohol, glycyrrhizin, Sodium Cyclamate, gelatin, aspartame, flavoring banana essence, flavoring pineapple essence, vanillin, fragrant citrus essence, flavoring orange essence, Herba Menthae essence, ginseng essence, strawberry essence, citric acid and the citric acid;
Described fluidizer is selected from one or more in micropowder silica gel, Pulvis Talci, the hydrated sodium aluminosilicate;
Described lubricant is selected from one or more in magnesium stearate, calcium stearate, zinc stearate, glyceryl monostearate, Polyethylene Glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyethylene monostearate, single Laurel sucrose acid ester, sodium laurylsulfate, magnesium laurylsulfate, Stepanol MG and the Pulvis Talci;
Described effervescent is the mixture of malic acid, citric acid or citric acid and sodium bicarbonate or sodium carbonate;
Described crylic acid resin is selected from homemade acrylic resin I, II, III or IV, perhaps Eudragit
Series.
3. calcium gluconate oral disintegrating tablet according to claim 2, wherein said Eudragit
Series is Eudragit
E100.
4. preparation method that is used for the described calcium gluconate oral disintegrating tablet of claim 1 is characterized in that being made up of following steps:
The first step is got coating material, with the dissolving of the solvent that adapts with it and to be diluted to debita spissitudo standby, get calcium gluconate again and place ebullated bed to make boiling, spray into above-mentioned solution with suitable speed then and carry out powder coating, get calcium gluconate powder coated granule, dry back sieving for standby;
Second step took by weighing correctives and the feed particles after first step taste masking is handled according to quantity, and mix homogeneously is standby;
The 3rd step took by weighing filler, disintegrating agent, effervescent, fluidizer and mix homogeneously according to quantity, made evenly again with through second mixing of materials that goes on foot gained, and adding lubricant mixing is standby;
The 4th step gained material detects through intermediate, determine that sheet is heavy after, send into the tablet machine tabletting promptly.
5. preparation method according to claim 4, wherein, described coating material is Eudragit
E100, described solvent are the medicinal alcohol more than 95%.
6. according to claim 4 or 5 described preparation methoies, the hardness that it is characterized in that the tablet that obtains is between 10 to 45 newton, and disintegration time is at 1-60 in second.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410086320XA CN1297263C (en) | 2004-10-25 | 2004-10-25 | Calcium gluconate oral disintegrating tablet and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410086320XA CN1297263C (en) | 2004-10-25 | 2004-10-25 | Calcium gluconate oral disintegrating tablet and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1634010A CN1634010A (en) | 2005-07-06 |
| CN1297263C true CN1297263C (en) | 2007-01-31 |
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ID=34847421
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200410086320XA Expired - Fee Related CN1297263C (en) | 2004-10-25 | 2004-10-25 | Calcium gluconate oral disintegrating tablet and its preparation process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102342400A (en) * | 2011-06-28 | 2012-02-08 | 文渊 | High-calcium xylitol |
| CN103284963A (en) * | 2012-02-28 | 2013-09-11 | 海南卫康制药(潜山)有限公司 | Children calcium gluconate-milk composition freeze-dried oral disintegrating tablet and preparation method thereof |
| CN105012340B (en) * | 2015-08-21 | 2018-07-06 | 上海华源安徽锦辉制药有限公司 | A kind of pharmaceutical composition containing calcium citrate and preparation method thereof |
| CN107156407A (en) * | 2017-04-10 | 2017-09-15 | 湖南文理学院 | A kind of threeleaf akebia pressed candy and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5032406A (en) * | 1989-02-21 | 1991-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Dual-action tablet |
| JPH09194381A (en) * | 1996-01-17 | 1997-07-29 | Kowa Co | Chewable tablet containing calcium salt |
| CN1476826A (en) * | 2003-07-30 | 2004-02-25 | 北京中西经纬释药技术有限公司 | Oral disintegrant tablet and its preparation method |
-
2004
- 2004-10-25 CN CNB200410086320XA patent/CN1297263C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5032406A (en) * | 1989-02-21 | 1991-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Dual-action tablet |
| JPH09194381A (en) * | 1996-01-17 | 1997-07-29 | Kowa Co | Chewable tablet containing calcium salt |
| CN1476826A (en) * | 2003-07-30 | 2004-02-25 | 北京中西经纬释药技术有限公司 | Oral disintegrant tablet and its preparation method |
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| CN1634010A (en) | 2005-07-06 |
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