CN1586461A - Local anesthesia fusion spray cloth for human body local anesthesia and preparing method - Google Patents
Local anesthesia fusion spray cloth for human body local anesthesia and preparing method Download PDFInfo
- Publication number
- CN1586461A CN1586461A CN 200410052779 CN200410052779A CN1586461A CN 1586461 A CN1586461 A CN 1586461A CN 200410052779 CN200410052779 CN 200410052779 CN 200410052779 A CN200410052779 A CN 200410052779A CN 1586461 A CN1586461 A CN 1586461A
- Authority
- CN
- China
- Prior art keywords
- local anesthesia
- fusion
- local
- spray cloth
- fusion spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The present invention belongs to the field of medical material technology, and provides one kind of local anesthesia fusion spray cloth for local anesthesia of human body. The local anesthesia fusion spray cloth consists of anaesthetic and non-toxic polymer fusion spray cloth as carrier. It has the features of sustained released anaesthetic, fine fusion spray cloth, soft hand feeling and less pain produced in wound and is suitable for clinical use. The present invention adopts physically adhered fusion sprayed fiber net with short high temperature operation time and less decomposition and suitable for industrial production.
Description
Technical field:
The invention belongs to medical material tech field.Be specifically related to a kind of local anesthesia (local anaesthesia) fusion spray cloth product that is used for human body local anesthesia and preparation method thereof.
Background technology:
Clinically, operate on, burn because of operation or the pain of scald etc., and avoid the untoward reaction that causes because of pain for alleviating human body, adopt usually human body among a small circle in the medical procedure of enforcement local anesthesia (local anaesthesia).At present the local anaesthesia method that adopts has: for example inject or quiet notes local anesthetic, but the method is often because of the disposable high toxic and side effects of concentration that enters human body is bigger, and lacks with medical treatment cost height, curative effect; Another kind method is that local anesthesia fiber (local anaesthesia fiber) is made the dressing wrapping or sticked on human body wound mouth, play local anesthetic action, but wherein the preparation of local anaesthesia fiber is to adopt the chemical graft method, this method production cost height, technological process are long, and by the local anaesthesia dressing of local anaesthesia fiber production when being used for human body local anesthesia, often exist medicament to discharge uneven defective.The inventor has designed a kind of employing physical blending method through research, and the local anaesthesia medicament is become the technology of fiber with nontoxic macromolecule melt co-blended spinning, sees Chinese patent application numbers 200410024984.3.But this medical dressing also is a process makes medical cloth with fiber, and then makes medical dressing, and therefore above-mentioned process route is still long.
Summary of the invention:
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and the research design flow process is shorter, the technology of the preparation local anaesthesia fusion spray cloth that operation is easy.
The invention provides a kind of local anaesthesia fusion spray cloth product that is used for human body local anesthesia, this local anaesthesia fusion spray cloth product comprises active component local anesthetic and nontoxic level polymer fusion spray cloth carrier composition, and wherein the addition of local anesthetic in local anaesthesia fusion spray cloth product is in weight % 8.0～25.0%.
The local anesthetic that the present invention selects for use is tetracaine, bupivacaine, procaine or lignocaine; The polymer support that fusion spray cloth is selected for use is polyethylene or polypropylene.
Another object of the present invention provides a kind of manufacture method that is used for the local anaesthesia fusion spray cloth of human body local anesthesia.
Technology path of the present invention is:
Polymer support (polyethylene or polyacrylic section) → screw rod fusion → dosing pump → melt and spray template → hot-air stretching → fleece to accept tube → local anesthesia fusion spray cloth injection local anaesthesia medicament → shaping reel → packing.
Method of the present invention comprises the following steps:
Choosing of polymer support in conjunction with the characteristics that melt and spray spinning, selected the section of the nontoxic polymer support of high fusion index for use, and polypropylene or poly melt index are: 30～500;
Screw rod fusion: polyethylene or the section of polypropylene high fusion index are entered extruder type spinning machine fusion metering extruding, when extruding, pass through preheating zone, a district, two districts, three districts and bend pipe flange district respectively;
Injection is drawn into cloth: after the macromolecule melt after the uniform temperature fusion forms certain pressure, by template injection thread, stick to rustless steel after the air high-speed stretch by heating and accept tube, when melting and spraying thread near softening point, evenly be sprayed on local anaesthetics in the fusion spray cloth, thereby among the fusion spray cloth that the powdery local anaesthetics is sticked to equably batch, form and melt and spray local anaesthesia cloth by the fleece lay-up.
The screw spinning that melts and sprays the molten polymer section in the inventive method is respectively distinguished temperature and is respectively: 90～95 ℃ of preheating zones; One district: 100～150 ℃; Two districts: 160～205 ℃; Three districts: 170～280 ℃; Bend pipe flange district: 160～260 ℃.
The melt blown die plate temperature is 220～350 ℃ in the inventive method; Hot blast temperature is 280～320 ℃; Blast is 1.2～8.0kg/cm
2It is 110～150 ℃ that meltblown fiber web is accepted the tube temperature; Fusion spray cloth coiling speed: 20～100m/min, local anaesthetics expulsion pressure: 0.1～1.2kg/cm
2
Principle of the present invention is that local anaesthetics is distributed in the polyethylene of high fusion index or the fusion spray cloth that the polypropylene injection forms equably, makes the biological activity fusion spray cloth that human body is had anesthetic action.Wherein active component is a local anaesthetics, by local anaesthetics being sprayed being bonded in the screen cloth in the fusion spray cloth thread, when this fusion spray cloth dressing that contains local anaesthetics touches the skin trauma mouth of human body mucosa or breakage, local anaesthetics wherein is discharged in the microcirculation in human body by people's body fluid lentamente, thereby alleviate human body pain, reach the effect of human body local anesthesia.
It is as follows that the every after tested gram of local anaesthesia fusion spray cloth product of the present invention melts and sprays in the local anaesthesia cloth seven days burst size:
Time local anaesthetics burst size (mg)
First day 5.8
Second day 4.2
The 3rd day 3.1
The 4th day 1.12
The 5th day 0.90
The 6th day 0.51
The 7th day 0.31
This melts and sprays local anaesthesia cloth sample polymer support: polypropylene, the local anaesthetics of interpolation: tetracaine, addition: 16%.
Product of the present invention has following characteristics:
1. melt and spray local anaesthesia cloth and have the advantages that to continue evenly to discharge local anaesthetics, therefore can avoid adopting the excessive toxic and side effects that causes of injection local anaesthetics concentration, very convenient simple when the patient uses.
2. the present invention adopts the physical adherence meltblown fiber web, and the high-temperature operation time is short, and the local anaesthesia medicament is difficult for decomposing.
3. the fusion spray cloth fiber finer is soft, helps reducing the pain of wound.
The specific embodiment:
Embodiment 1
Raw material: polypropylene chip (nontoxic high fusion index)
Melt index: 100
Local anaesthetics composition: tetracaine (addition 16%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
92 165 198 205 210
Melt blown die plate temperature: 289 ℃
Hot blast temperature: 310 ℃
Hot-blast pressure: 3.5kg/cm
2
Melt and spray and accept net tube temperature: 130 ℃
Local anaesthetics expulsion pressure: 0.2kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 8 days.
Embodiment 2
Raw material: polypropylene chip (nontoxic fibre-grade)
Melt index: 48
Local anaesthetics composition: bupivacaine (addition 15%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
90 135 170 180 185
Melt blown die plate temperature: 272 ℃
Hot blast temperature: 285 ℃
Hot-blast pressure: 2.8kg/cm
2
Melt and spray and accept net tube temperature: 115 ℃
Local anaesthetics expulsion pressure: 0.18kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 9 days.
Embodiment 3
Raw material: polypropylene chip (nontoxic fibre-grade)
Melt index: 150
Local anaesthetics composition: procaine (addition 20%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
90 150 189 195 205
Melt blown die plate temperature: 278 ℃
Hot blast temperature: 300 ℃
Hot-blast pressure: 3.2kg/cm
2
Melt and spray and accept net tube temperature: 120 ℃
Local anaesthetics expulsion pressure: 0.32kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 13 days.
Embodiment 4
Raw material: polypropylene chip (nontoxic high fusion index)
Melt index: 55
Local anaesthetics composition: lignocaine (addition 25%)
Melt and spray screw rod respectively distinguish temperature (℃):
Bend pipe flange district, three districts, two districts, one district, preheating zone
90 125 155 178 170
Melt blown die plate temperature: 268 ℃
Hot blast temperature: 278 ℃
Hot-blast pressure: 2.6kg/cm
2
Melt and spray and accept net tube temperature: 105 ℃
Local anaesthetics expulsion pressure: 0.35kg/cm
2
This local anaesthesia fusion spray cloth is local anaesthesia medicament slow-release time in normal saline: 16 days.
Claims (5)
1, a kind of local anesthesia fusion spray cloth product that is used for human body local anesthesia, it is characterized in that this product comprises local anesthetic and the nontoxic level polymer fusion spray cloth carrier composition as active ingredient, wherein the addition of local anesthetic in local anesthesia fusion spray cloth product is in weight % 8.0～25.0%.
2, a kind of preparation method that is used for the local anesthesia fusion spray cloth product of human body local anesthesia is characterized in that this method comprises the following steps:
(1) choosing of polymer support: the section of selecting the nontoxic level polymer support of high fusion index for use;
(2) screw rod fusion: the polymer chips that step (1) is selected for use enters extruder type spinning machine fusion metering extruding, and respectively by preheating zone, a district, two districts, three districts and bend pipe flange district, the temperature in each district is inequality when extruding;
(3) injection is drawn into cloth: after the macromolecule melt after step (2) fusion forms certain pressure, by template injection thread, stick to rustless steel after the air high-speed stretch by heating and accept tube, when melting and spraying thread near softening point, evenly be sprayed on local anesthetic in the fusion spray cloth, thereby among the fusion spray cloth that the powdery local anesthetic is sticked to equably batch, form and melt and spray local anesthesia cloth by the fleece lay-up.
3, a kind of local anesthesia fusion spray cloth product that is used for human body local anesthesia according to claim 1 is characterized in that wherein said local anesthetic is selected from tetracaine, bupivacaine, procaine or lignocaine; Polymer is selected from polyethylene or polypropylene.
4, a kind of preparation method that is used for the local anesthesia fusion spray cloth product of human body local anesthesia according to claim 2 is characterized in that the fused temperature of respectively distinguishing of wherein said step (2) screw rod is respectively: 90～95 ℃ of preheating zones; One district: 100～150 ℃; Two districts: 160～205 ℃; Three districts: 170～280 ℃; Bend pipe flange district: 160～260 ℃.
5, a kind of preparation method that is used for the local anesthesia fusion spray cloth product of human body local anesthesia according to claim 2 is characterized in that it is 220～350 ℃ that wherein said step (3) is sprayed the melt blown die plate temperature that is drawn in the cloth; Hot blast temperature is 280～320 ℃; Blast is 1.2～8.0kg/cm
2It is 110～150 ℃ that meltblown fiber web is accepted the tube temperature; Fusion spray cloth coiling speed: 20～100m/min, local anaesthetics expulsion pressure: 0.1～1.2kg/cm
2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100527798A CN1314392C (en) | 2004-07-13 | 2004-07-13 | Local anesthesia fusion spray cloth for human body local anesthesia and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100527798A CN1314392C (en) | 2004-07-13 | 2004-07-13 | Local anesthesia fusion spray cloth for human body local anesthesia and preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1586461A true CN1586461A (en) | 2005-03-02 |
| CN1314392C CN1314392C (en) | 2007-05-09 |
Family
ID=34602597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100527798A Expired - Fee Related CN1314392C (en) | 2004-07-13 | 2004-07-13 | Local anesthesia fusion spray cloth for human body local anesthesia and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1314392C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588917A (en) * | 2020-05-15 | 2020-08-28 | 广东顺事德智能科技有限公司 | Melt-blown cloth for local anesthesia of human body and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US398185A (en) * | 1889-02-19 | Mail-bag | ||
| CA2092581C (en) * | 1992-12-22 | 2003-10-14 | Judith K. Faass | Self-adhesive nonwoven elastic compressible composite material |
| ATE515209T1 (en) * | 2000-04-06 | 2011-07-15 | Kimberly Clark Co | FINGERLING |
| US6776858B2 (en) * | 2000-08-04 | 2004-08-17 | E.I. Du Pont De Nemours And Company | Process and apparatus for making multicomponent meltblown web fibers and webs |
| US6499982B2 (en) * | 2000-12-28 | 2002-12-31 | Nordson Corporation | Air management system for the manufacture of nonwoven webs and laminates |
-
2004
- 2004-07-13 CN CNB2004100527798A patent/CN1314392C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588917A (en) * | 2020-05-15 | 2020-08-28 | 广东顺事德智能科技有限公司 | Melt-blown cloth for local anesthesia of human body and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1314392C (en) | 2007-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1166505A (en) | Absorbable copolymers and blends of 6,6,-dialkyl-1,4-dioxepan-2-one and its cyclic dimer | |
| CN1942619A (en) | Fibers, nonwovens and articles containing nanofibers produced from high glass transition temperature polymers | |
| CN1942617A (en) | Fibers, nonwovens and articles containing nanofibers produced from broad molecular weight distribution polymers | |
| CN1837274A (en) | Degradable and absorbable polymer nano fibrous membrane materials and preparation process and use thereof | |
| Joshi et al. | Advances in topical drug delivery system: Micro to nanofibrous structures | |
| CN1714838A (en) | Medical gel and its preparing method and device | |
| CN1272149A (en) | Crimp enhancement additive for multicomponent filaments | |
| CN100351439C (en) | Negative ion fiber and preparation method thereof | |
| CN1314392C (en) | Local anesthesia fusion spray cloth for human body local anesthesia and preparing method | |
| CN101700226A (en) | Naltrexone long-acting sustained-release preparation with no need of coating and preparation method thereof | |
| CN114558163B (en) | Preparation method and application of traditional Chinese medicine microsphere-loaded nanofiber dressing | |
| CN1444616A (en) | Method and product for reducing latex exposure | |
| CN1893990A (en) | A balloon for use in angioplasty | |
| CN105056311A (en) | Anal fistula thread of three-dimensional composite structure and preparation method of anal fistula thread | |
| CN101049514A (en) | Antibacterial anti hemorrhagic antalgic dressing of medical use, preparation and application | |
| CN108721680A (en) | A kind of polylactic acid/Lappaconitine composite fibre and its preparation and application | |
| CN112239919A (en) | Polymer nano biological filter element material and preparation method and application thereof | |
| CN105586719A (en) | Soft high-strength terylene SMS composite non-woven material and manufacturing method thereof | |
| KR100336700B1 (en) | Biodegradable guided tissue regeneration in teriodontal dental therapy and methods of producing the same | |
| CN1587453A (en) | Photocatalytic and antiseptic far infrared fiber and its preparing method | |
| WO2016095824A1 (en) | Anti-infective dressing bag and fabricating method therefor | |
| CN1583182A (en) | Local anesthesitic fabrics for human and preparation thereof | |
| KR101008001B1 (en) | Controlled Drug Release System by fluorination based on biodegradable Nano-Fibers and Manufacturing Method Thereof | |
| CN112853605A (en) | Completely degradable micro-nano fiber composite material and preparation method thereof | |
| CN110786989B (en) | Preparation method of medical antibacterial gel dressing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070509 Termination date: 20200713 |