CN1583182A - Local anesthesitic fabrics for human and preparation thereof - Google Patents
Local anesthesitic fabrics for human and preparation thereof Download PDFInfo
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- CN1583182A CN1583182A CN 200410024984 CN200410024984A CN1583182A CN 1583182 A CN1583182 A CN 1583182A CN 200410024984 CN200410024984 CN 200410024984 CN 200410024984 A CN200410024984 A CN 200410024984A CN 1583182 A CN1583182 A CN 1583182A
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Abstract
A locally anesthetic fibre product for the local anesthesia of human body is composed of local anesthetic and polymer carrier. It can durably release the anesthetic.
Description
Technical field:
The invention belongs to medical material tech field.Be specifically related to a kind of local anesthesia (local anaesthesia) fiber product and preparation method that is used for human body local anesthesia.
Background technology:
Clinically, for alleviating the pain that human body is operated on, burns, scalded and hurt because of operation, and avoid the untoward reaction that causes because of pain, adopt usually human body among a small circle in the medical procedure of enforcement local anesthesia.General local anesthesia method has following several at present: 1. inject or quiet notes local anesthetic; 2. the local anesthesia fiber is made the dressing wrapping or sticked on human body wound mouth, play the effect of local anesthesia, minimizing wound pain.But the former is after the patient uses local anaesthetics, often cause because of the disposable concentration high toxic and side effects that enters human body is big, and medical treatment cost height, curative effect is short.And for the anesthesia fiber, existing production utilizes chemical graft process to prepare, and this technological process is long, the production cost height has brought certain difficulty, and the local anesthesia dressing of its production is when being used for medical local anaesthesia, there is the uneven defective of medicament slow release, impact effect.
Summary of the invention:
Technical problem to be solved by this invention is to overcome above-mentioned weak point, designs the new technology of the preparation local anesthesia fiber (local anaesthesia fiber) that a kind of flow process is short, operation is simple.
The invention provides a kind of local anaesthesia fiber product that is used for human body local anesthesia, this local anaesthesia fiber product comprises active component local anesthetic and nontoxic fibre-grade polymer support composition, and wherein local anesthetic is 8.0～25.0% at the addition with the polymer support blend.
Local anesthetic of the present invention is tetracaine, bupivacaine, procaine or lignocaine; The polymer support of selecting for use is polyethylene, polypropylene or low-melting point polyester (LPET terylene low melting point).
Another object of the present invention has provided a kind of being used for from the local anaesthesia fiber production method of this part anesthesia, and this method comprises the following steps:
(1) blend pelletize: fibre-grade polymer chips melt spinning carrier and local anesthetic are pressed the formula proportion mixing and stirring, enter heat fused, stirring-granulating in the double screw extruder that meshes shape, medicine is evenly distributed in fiber melt;
(2) spinning: with the particle after step (1) blend, enter the extruder type spinning machine melt extruded, 90 ℃～220 ℃ of temperature ranges quantitatively are input into filament spinning component melt extrusion thread by dosing pump then, 180 ℃～215 ℃ of spinning body temperatures, spinning speed 200～800m/min;
(3) reel: the melt thread after step (2) blend is by after extruding in the filament spinning component, through the blowing cooling, 15～25 ℃ of cooling pathogenic wind-warm, the cooling wind speed is 0.2～0.7m/s, and through after 50～120 times the spinning head prestretched around going into mound bobbins, form the nascent local anaesthesia fiber of polymer support and local anaesthetics mixture thread cooling curing;
(40 after-drawing: 2.5～5 times of total stretching ratios, 50～85 ℃ of draft temperatures under the condition that heat setting temperature is 115～145 ℃, are finished after-drawing by the speed ratio of three road rollers;
(5) finished product package: make the package product at last through the local anaesthesia fiber that above-mentioned steps makes.
Be divided into a district, two districts, three districts and bend pipe flange district when entering screw rod in the spinning technique of step in the inventive method (2), the temperature range in each district is followed successively by 150 ℃～215 ℃ in 90～150 ℃ in a district, 150～210 ℃ in two districts, 160～220 ℃ in three districts and bend pipe flange district.
Principle of the present invention is that the local anaesthesia medicament is distributed in the fiber interface that polymer support forms equably, makes a kind of bioactive fiber with anesthetic action.Wherein active component is a local anesthetic, is stored in the fiber by blend.When the narcoticness fiber touched human body mucosa or damaged skin trauma mouth, local anaesthetics wherein slowly was discharged in the human body by body fluid, thereby eased the pain and play the effect of human body local anesthesia.
Characteristics of the present invention are:
1, the local anaesthesia fiber can continue to discharge local anaesthetics equably, avoids the excessive toxic and side effects that causes of local anaesthetics concentration.The burst size of the every gram local anaesthesia of the present invention fiber every day is as follows after tested:
Time mg
First day 6.90
Second day 3.76
The 3rd day 1.88
The 4th day 1.29
The 5th day 1.10
The 6th day 0.94
The 7th day 0.41
This sample polymer carrier: polyethylene, add local anaesthetics: tetracaine, addition: 11%.
2, the present invention adopts physical blending technology, and flow process is short, method is easy, cost is low, implements suitability for industrialized production easily.
The specific embodiment
Embodiment 1
Raw material: polyethylene section (nontoxic fibre-grade)
Local anaesthetics tetracaine (addition: 11%)
Spinning temperature (℃): screw rod is respectively distinguished bend pipe flange district, three districts, two districts
150 180 195 190
195 ℃ of spinning manifolds
Cooling wind speed 0.48m/s
19 ℃ of cooling pathogenic wind-warm
Spinning (coiling) speed 380m/min
3.6 times of the total multiplying powers of after-drawing
68 ℃ of draft temperatures
115 ℃ of heat setting temperatures
This local anaesthesia fiber local anaesthesia medicament release time in normal saline: 8 days
Embodiment 2
Raw material: low-melting point polyester (nontoxic fibre-grade) T
m: 110 ℃
Local anaesthetics bupivacaine (addition: 12%)
Spinning temperature (℃): screw rod is respectively distinguished bend pipe flange district, three districts, two districts
95 135 185 190
185 ℃ of spinning manifolds
Cooling wind speed 0.32m/s
22 ℃ of cooling pathogenic wind-warm
Spinning (coiling) speed 560m/min
After-drawing is total to stretch doubly 4.2 times
80 ℃ of draft temperatures
105 ℃ of heat setting temperatures
This local anaesthesia fiber local anaesthesia medicament release time in normal saline: 10 days
Embodiment 3
Raw material: high fusion index polypropylene (nontoxic fibre-grade)
Local anaesthetics procaine (addition: 15%)
Spinning temperature (℃): screw rod is respectively distinguished bend pipe flange district, three districts, two districts
105 155 185 190
195 ℃ of spinning manifolds
Cooling wind speed 0.52m/s
18 ℃ of cooling pathogenic wind-warm
Spinning (coiling) speed 450m/min
4.5 times of the total stretching ratios of after-drawing
75 ℃ of draft temperatures
125 ℃ of heat setting temperatures
This local anaesthesia fiber local anaesthesia medicament release time in normal saline: 15 days
Embodiment 4
Raw material: polyethylene section (nontoxic fibre-grade)
Local anaesthetics: procaine (addition 12%)
Spinning temperature (℃) screw rod respectively distinguishes bend pipe flange district, three districts, two districts
145 170 185 180
Spinning manifold: 182 ℃
Cooling wind speed: 0.50m/s
Cooling pathogenic wind-warm: 18 ℃
Spinning (coiling) speed: 350m/min
The total multiplying power of after-drawing: 3.7 times
Draft temperature: 65 ℃
Heat setting temperature: 112 ℃
This local anaesthesia fiber local anaesthesia medicament release time in normal saline: 9 days
Embodiment 5
Raw material: polyethylene section (nontoxic fibre-grade)
Local anaesthetics: lignocaine (addition 12%)
Spinning temperature (℃) screw rod respectively distinguishes bend pipe flange district, three districts, two districts
145 175 185 175
Spinning manifold: 180 ℃
Cooling wind speed: 0.49m/s
Cooling pathogenic wind-warm: 16 ℃
Spinning (coiling) speed: 360m/min
The total multiplying power of after-drawing: 3.65 times
Draft temperature: 64 ℃
Heat setting temperature: 110 ℃
This local anaesthesia fiber local anaesthesia medicament release time in normal saline: 8 days
Claims (4)
1, a kind of local anesthesia fiber product that is used for human body local anesthesia, it is characterized in that this local anesthesia fiber product comprises active ingredient local anesthetic and nontoxic fibre-grade polymer support composition, wherein local anesthetic is 8.0～25.0% at the addition with the polymer support blend.
2, a kind of local anesthesia fiber product that is used for human body local anesthesia according to claim 1 is characterized in that wherein said active ingredient local anesthetic is tetracaine, bupivacaine, procaine or lignocaine; Nontoxic fibre-grade polymer support is polyethylene, polypropylene or low-melting point polyester.
3, a kind of preparation method that is used for the local anesthesia fiber product of human body local anesthesia is characterized in that this method comprises the following steps:
(1) blend pelletize: fibre-grade polymer chips melt spinning carrier and local anesthetic are pressed the formula proportion mixing and stirring, enter heat fused, stirring-granulating in the double screw extruder that meshes shape, medicine is evenly distributed in fiber melt;
(2) spinning: with the particle after step (1) blend, enter the extruder type spinning machine melt extruded, 90 ℃～220 ℃ of temperature ranges quantitatively are input into filament spinning component melt extrusion thread by dosing pump then, 180 ℃～215 ℃ of spinning body temperatures, spinning speed 200～800m/min;
(3) reel: the melt thread after step (2) blend is by after extruding in the filament spinning component, through the blowing cooling, 15～25 ℃ of cooling pathogenic wind-warm, the cooling wind speed is 0.2～0.7m/s, and through after 50～120 times the spinning head prestretched around going into mound bobbins, form the nascent local anaesthesia fiber of polymer support and local anaesthetics mixture thread cooling curing;
(4) after-drawing: 2.5～5 times of total stretching ratios, 50～85 ℃ of draft temperatures under the condition that heat setting temperature is 115～145 ℃, are finished after-drawing by the speed ratio of three road rollers;
(5) finished product package: make the package product at last through the local anaesthesia fiber that above-mentioned steps makes.
4, a kind of local anesthesia fiber preparation method that is used for human body local anesthesia according to claim 3, it is characterized in that in the spinning technique of wherein said step (2), be divided into a district, two districts, three districts and bend pipe flange district when entering screw rod, the temperature range in each district is followed successively by 150 ℃～215 ℃ in 90～150 ℃ in a district, 150～210 ℃ in two districts, 160～220 ℃ in three districts and bend pipe flange district.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024984 CN1583182A (en) | 2004-06-08 | 2004-06-08 | Local anesthesitic fabrics for human and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024984 CN1583182A (en) | 2004-06-08 | 2004-06-08 | Local anesthesitic fabrics for human and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1583182A true CN1583182A (en) | 2005-02-23 |
Family
ID=34601083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410024984 Pending CN1583182A (en) | 2004-06-08 | 2004-06-08 | Local anesthesitic fabrics for human and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1583182A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109316470A (en) * | 2018-11-05 | 2019-02-12 | 中国医学科学院基础医学研究所 | A kind of pharmaceutical composition and its preparation method and application containing Bupivacaine |
-
2004
- 2004-06-08 CN CN 200410024984 patent/CN1583182A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109316470A (en) * | 2018-11-05 | 2019-02-12 | 中国医学科学院基础医学研究所 | A kind of pharmaceutical composition and its preparation method and application containing Bupivacaine |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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