CN1584559A - Sample collecting and detecting apparatus, method thereof - Google Patents
Sample collecting and detecting apparatus, method thereof Download PDFInfo
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- CN1584559A CN1584559A CN 200410024782 CN200410024782A CN1584559A CN 1584559 A CN1584559 A CN 1584559A CN 200410024782 CN200410024782 CN 200410024782 CN 200410024782 A CN200410024782 A CN 200410024782A CN 1584559 A CN1584559 A CN 1584559A
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- 238000012360 testing method Methods 0.000 claims abstract description 61
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- 230000008859 change Effects 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 7
- 238000012216 screening Methods 0.000 claims description 7
- 239000003292 glue Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 description 12
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
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- 238000002649 immunization Methods 0.000 description 9
- 230000002550 fecal effect Effects 0.000 description 8
- 210000001072 colon Anatomy 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 4
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
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- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
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- 229960001867 guaiacol Drugs 0.000 description 2
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
A device for sample collection and detection consists of collection card and test card. It is featured as having four collecting cards being connected together through folding trace, having collection window and collection carrier on the first collection card, having the same thing on the second one, having through hole on the first carrier, placing the first through hole in cooresponding to position of the second collection carrier and collection window under folding state of the two cards.
Description
Technical field
The invention belongs to medical class article, can once collect a kind of sample collection and pick-up unit and method that detected sample simultaneously can the repeated detection sample specifically exactly.
Background technology
The main generaI investigation that is used for middle-aged and old colon cancers of fecal occult blood test at present.So-called lower digestive tract is from counting below the pleura connecting portion of 12 intestines.Comprise small intestine, large intestine and anus.Wherein large intestine comprises colon ascendens transverse colon and colon descendens, ileum, rectum.The more common colonic diseases of western countries, colon cancer are second killers after lung cancer.And occult blood can help to detect the health status of colon before the formation malignant tumour.In the U.S., the people of suggestion more than 50 years old will do a fecal occult blood check every year.
Detect fecal occult blood and adopt chemical method and two kinds of methods of immunization.
Chemical method detects fecal occult blood, and colourless guaiacol is a reaction substrate on the collection carrier with handling usually, in stool, there is haemoglobin to exist, haemoglobin catalysis hydrogen peroxide produces free state oxygen, it is blue that the colourless guaiacol of free state oxygen oxidation makes it to become, when hemoglobin-free exists in detecting sample, then there be not blue the appearance.Detect the collection of sample and detect in the United States Patent (USP) patent No. 3996006,4365970, in all revealed.More existing problems during the chemical method that solves other United States Patent (USP) detects, as the influence of interfering material, the stability of protoheme in the collection process improves the sensitivity of detection etc.
Immunization comparative chemistry method has higher sensitivity, can reach 50ng/ml, and chemical method only has 100ug/ml.The specificity of simultaneous immunization is higher than chemical method, shows that it is not subjected to the influence of allos animal blood, is not subjected to the influence of vitamin and enzyme.And the use of immunization will depend on complete haemoglobin, and this is its weak point.Be positioned at lower digestive tract especially below the colon ascendens, because the few albumen of digestive juice more easily maintains good working condition, immunization method is more reliable than chemical method in theory.But other positions are hemorrhage, because through small intestine, the protein part of digestive juice meeting havoc haemoglobin.Because the chemical method check is the heme moiety of haemoglobin, therefore than immunization the higher ability that detects is arranged.Fecal occult blood is used to detect that a spot of naked eyes can not observed blood in the stool sample.Gastrorrhagia for example, hepatic disease, the pancreas pathology all has bleeding to take place.Recognize that from clinician's feedback information the occult blood check of this class disease should be adopted chemical method.But gastral disease is not limited only to be common in the colon position, and the pathology at all the other positions is still followed a spot of hemorrhage generation.Two methods of inspection are used and can have complementary advantages for above-mentioned reasons, and more a kind of method has more fully clinical meaning.
Though the United States Patent (USP) patent No. 6033627 has disclosed the device of test card, do not disclose and collect the collector cards device that detects sample.The United States Patent (USP) patent No. 6165416 has disclosed a kind of pick-up unit, and this device can reach the purpose of once collecting the sample repeated detection, but has operation loaded down with trivial details, unhygienic, and sample is easily to shortcomings such as tester and detected person pollute.
Summary of the invention
Based on above reason and used in the market joint survey is that two kinds of methods are simply pieced together, and patient and doctor's operation are all inconvenient.Can limit the use of fecal occult blood like this, omit the ill crowd of possibility.The objective of the invention is to solve the defective of above-mentioned prior art, and a kind of collection and pick-up unit and method of fecal occult blood of handled easily are provided, make patient do once to collect and just can do gastral more comprehensive check.And the doctor also needn't feel not happy in the face of a large amount of stool samples.
The technical solution adopted in the present invention.This sample collection and pick-up unit mainly comprise collector cards and test card, and described collector cards comprises that mainly collector cards last slice, first collects sheet, second and collect sheet under sheet and the collector cards, and four fuse by folding line; Have first on the first collection sheet and collect window, be bonded with on one side of the first collection sheet greater than first and collect the first collection carrier of window ara size, have second on the second collection sheet and collect window, be bonded with on the side of the second collection sheet greater than second and collect the second collection carrier of window ara size; Have first through hole on the first collection carrier, collect sheet and second first and collect under the sheet folded state, the position of first through hole and the second collection carrier and the second collection window is corresponding.
The collection of detected sample of the present invention and detection method, 1), open collector cards last slice mainly may further comprise the steps and realize:, keep the first collection sheet and second to collect sheet and be in folded state, detected sample is applied in the first collection window of collecting on the sheet, the detected sample of a part stays in first and collects on the carrier, another part stays on the second collection carrier by first first through hole of collecting on the carrier, and the collector cards last slice that closes is sent to hospital then and detects; 2), the test card last slice of test card is opened sheet under expansion collector cards last slice and the collector cards; Tear the screening glass that is positioned at sheet under collector cards last slice and the collector cards; Allowing collect has the first collection carrier and second of detected sample to collect the sample region of acceptance that carrier is close to first test-strips and second test-strips respectively; 3), the sheet under test card last slice and the test card that closes; First dripping hole on test card last slice drips first detectable, read testing result from first results window, come result of determination according to the change color situation, second dripping hole on test card last slice drips second detectable, observe testing result from second results window, come result of determination according to the change color situation.
The effect that the present invention is useful is: 1, once collect sample, can be used for the check of two kinds or two or more detection indexs.2, for detecting fecal occult blood.Chemical method detects owing to false positive verification and measurement ratio height, and the defective that the immunization check can chemically detect; When hemoglobin content was very high in a lot of or sample when the stool sample size, immunization detected and occurs false positive or omission easily, and chemical method has remedied the defective that immunization detects.3, improve the sensitivity of chemical method, because the color of stool itself can influence chemical method result's interpretation, the present invention can improve the resolution of change color by reading the method that window and sample separate.
Description of drawings
Fig. 1 is the perspective view of the collector cards folded state of the embodiment of the invention 1;
Fig. 2 is the perspective view of the collector cards last slice open mode of the embodiment of the invention 1;
Fig. 3 is the perspective view of the collector cards open mode of the embodiment of the invention 1;
Fig. 4 is the sectional structure synoptic diagram of the collector cards folded state of the embodiment of the invention 1;
Fig. 5 is the plane master's TV structure synoptic diagram under the whole deployed conditions of the collector cards of the embodiment of the invention 1;
Fig. 6 is the plane backsight structural representation under the whole deployed conditions of the collector cards of the embodiment of the invention 1;
Fig. 7 is the perspective view of the test card folded state of the embodiment of the invention 1;
Fig. 8 is the perspective view of the test card last slice open mode of the embodiment of the invention 1;
Fig. 9 is that the collector cards of the embodiment of the invention 1 and test card are used the synoptic diagram under the open mode;
Figure 10 is that the collector cards of the embodiment of the invention 1 and test card are used the synoptic diagram under the closure state;
Figure 11 is the plane master's TV structure synoptic diagram under the whole deployed conditions of the collector cards of the embodiment of the invention 2;
Figure 12 is the plane backsight structural representation under the whole deployed conditions of the collector cards of the embodiment of the invention 2.
Description of drawings: collector cards last slice 1, protection hole 1-1, screening glass 2, last slice edge 3, arc-shaped slit 4, sampling rod 5, first collects sheet 6, the first collects window 7, the first collection carriers 8, the first through hole 8-1, second collects carrier 9, the second through hole 9-1, and second collects sheet 10, second collects window 10-1, and sheet 11 under the collector cards; Test card last slice 12, last slice edge 13, the first dripping holes 14, impression 15, adhesive sticker 16, the first test-strips 17, second test-strips 18, sheet 19 under the test card, sample region of acceptance 19-1, adhesive glue 20, stator 21, stator edge 21-1, first detectable, 22, the second detectable, 23, the first results window 24, second results window, 25, the second dripping holes 26; Collector cards 27, test card 28, folding line 29, tearing mark 30, the three is collected sheet 31, the three and is collected window 31-1, and the 3rd collects carrier 32.
Embodiment
The invention will be described further below in conjunction with embodiment and accompanying drawing:
Embodiment 1: this sample collection and pick-up unit, mainly comprise collector cards 27 and test card 28, and described collector cards 27 comprises that mainly sheet 11, four fuses by folding line 29 under collector cards last slice 1, the first collection sheet 6, the second collection sheet 10 and the collector cards; Have first on the first collection sheet 6 and collect window 7, be bonded with on one side of the first collection sheet 6 greater than first and collect the first collection carrier 8 of window 7 area sizes, have second on the second collection sheet 10 and collect window 10-1, be bonded with on the side of the second collection sheet 10 greater than second and collect the second collection carrier 9 of window 10-1 area size; Have the first through hole 8-1 on the first collection carrier 8, collect sheet 6 and second first and collect under sheet 10 folded states, the position of the first through hole 8-1 and the second collection carrier 9 and the second collection window 10-1 is corresponding.Collector cards last slice 1 is provided with an edge 3, gets final product clamping in the arc-shaped slit 4 of the collector cards last slice edge 3 insertions first collection sheet 6.Have protection hole 1-1 under collector cards last slice 1 and the collector cards on the sheet 11, screening glass 2 links to each other by the hole wall of tearing mark 30 with protection hole 1-1, promptly adopts the structure of tearing mark to link together under screening glass 2 and collector cards last slice 1 and the collector cards between the sheet 11.
The collection of detected sample of the present invention and detection method: the detected person fills in personal information as shown in Figure 1 at the upper surface of the collector cards last slice 1 of collector cards 27; Open collector cards last slice 1, keep the first collection sheet 6 and second to collect sheet 10 and be in folded state, with detected sample evenly and be applied to first thinly and collect on the carrier 8, first collect carrier 8 and collected first on the sheet 6 by first and collect window 7 and form a certain size a collecting zone; Collect the first through hole 8-1 that a certain size is arranged on carrier 8 first, when on the first collection carrier 8, being coated with detected sample, the detected sample of a part stays on the first collection carrier 8, and another part stays on the second collection carrier 9 by the first first through hole 8-1 that collects on the carrier 8.Detected sample can be used sampling rod 5 pickings.The detected person closes and goes up card, collector cards last slice edge 3 is inserted first collect in the arc-shaped slit 4 of sheet 6, is sent to hospital then and detects.
In hospital, the doctor opens the test card last slice 12 of test card 28; Tear adhesive sticker 16.Adhesive glue between the sheet 11 under collector cards last slice 1 and the collector cards 20 is destroyed the back to launch.The collector cards of opening 27 is attached to the position of adhesive sticker 16, tears the screening glass 2 that is positioned at sheet 11 under collector cards last slice 1 and the collector cards simultaneously; Allowing collect has the first collection carrier 8 and second of detected sample to collect the sample region of acceptance 19-1 that carrier 9 is close to first test-strips 17 and second test-strips 18 respectively.The sheet 19 under test card last slice 12 and the test card that closes, test card last slice 12, impression 15 and be installed in that the stator on the sheet 19 21 forms internal force under the test card, chucking is close to the stator edge 21-1 of stator 21 in the last slice edge 13 that makes test card last slice 12.First dripping hole 14 on test card last slice 12 drips first detectable 22, reads testing result from first results window 24, comes result of determination according to the change color situation.Second dripping hole 26 on test card last slice 12 drips second detectable 23, observes testing result from second results window 25, comes result of determination according to the change color situation.
Embodiment 2: difference from Example 1 is, be connected with the 3rd collection sheet 31 by folding line 29 between the sheet 11 under the second collection sheet 10 and the collector cards, have the 3rd on the 3rd collection sheet 31 and collect window 31-1, be bonded with on one side of the 3rd collection sheet 31 on the 3rd collection carrier 32, the second collection carriers 9 greater than the 3rd collection window 31-1 area size and have the second through hole 9-1; Collect sheet 6, second first and collect under sheet 10 and the 3rd collection sheet 31 folded states, the position of the first through hole 8-1, the second through hole 9-1 and the 3rd collection carrier 32 and the 3rd collection window 31-1 is corresponding.
Simultaneously, described test card 28 mainly comprises sheet 19 under test card last slice 12 and the test card, between the two by impression 15 interconnection, wherein test card last slice 12 is provided with three groups of dripping holes and results window, sheet 19 is provided with the same number of test-strips with dripping hole and the corresponding position of results window under the test card, and the spacing of collecting carrier in the spacing of test-strips and the collector cards 27 adapts.
The concrete collection and detection method: the detected person opens collector cards last slice 1, and with detected sample evenly and be applied to first thinly and collect on the carrier 8, first collects carrier 8 is collected first on the sheet 6 by first and collect window 7 and form a certain size a collecting zone; Collect the first through hole 8-1 that a certain size is arranged on carrier 8 first.When on the first collection carrier 8, being coated with detected sample under the first collection sheet 6, the second collection sheet 10 and the 3rd collection sheet 31 folded states, collecting carrier first has for 8 times the second collection carrier 9 and the 3rd collection carrier 32, the second collection carriers 9 to collect a certain amount of detected sample by the first first through hole 8-1 that collects on the carrier 8; Because the second through hole 9-1 is less than the first through hole 8-1, the 3rd collects carrier 32 collects a certain amount of detected sample by the second second through hole 9-1 that collects on the carrier 9.Detected sample can be used sampling rod 5 pickings.The detected person closes and goes up card, collector cards last slice edge 3 is inserted first collect in the arc-shaped slit 4 of sheet 6, is sent to hospital then and detects.In hospital, doctor's method of operating is identical with embodiment 1, once collects the purpose that detected sample can detect sample simultaneously for three times thereby reach.
Claims (9)
1, a kind of sample collection and pick-up unit, mainly comprise collector cards (27) and test card (28), it is characterized in that: described collector cards (27) comprises that mainly collector cards last slice (1), first collects sheet (6), second and collect sheet (11) under sheet (10) and the collector cards, and four fuse by folding line (29); Have first on the first collection sheet (6) and collect window (7), be bonded with on one side of the first collection sheet (6) greater than first and collect the first collection carrier (8) of window (7) area size, have second on the second collection sheet (10) and collect window (10-1), be bonded with on the side of the second collection sheet (10) greater than second and collect the second collection carrier (9) of window (10-1) area size; Have first through hole (8-1) on the first collection carrier (8), collect sheet (6) and second first and collect under sheet (10) folded state, the position of first through hole (8-1) and the second collection carrier (9) and the second collection window (10-1) is corresponding.
2, sample collection according to claim 1 and pick-up unit, it is characterized in that: described test card (28) mainly comprises sheet (19) under test card last slice (12) and the test card, between the two by impression (15) interconnection, wherein test card last slice (12) is provided with first dripping hole (14), second dripping hole (26), first results window (24) and second results window (25), sheet under the test card (19) is provided with first test-strips (17) and second test-strips (18) with dripping hole and the corresponding position of results window, and first spacing of collecting the carrier (8) and the second collection carrier (9) adapts in the spacing of first test-strips (17) and second test-strips (18) and the collector cards (27).
3, sample collection according to claim 1 and 2 and pick-up unit is characterized in that: sheet under the described test card (19) is provided with stator (21) and the adhesive sticker (16) that is used for collector cards (27) location.
4, sample collection according to claim 1 and pick-up unit is characterized in that: described collector cards last slice (1) be provided with collector cards under arc-shaped slit (4) last slice edge (3) of clamping mutually on the sheet (11).
5, according to claim 1 or 4 described sample collection and pick-up units; it is characterized in that: have protection hole (1-1) under described collector cards last slice (1) and the collector cards on the sheet (11), screening glass (2) links to each other by the hole wall of tearing mark (30) with protection hole (1-1).
6, sample collection according to claim 1 and 2 and pick-up unit is characterized in that: the described first collection sheet (6) and second is collected to be provided with between the sheet (10) and is used for adhesive glue glued together (20).
7, sample collection according to claim 1 and pick-up unit, it is characterized in that: collect under sheet (10) and the collector cards second and be connected with the 3rd collection sheet (31) by folding line (29) between the sheet (11), have the 3rd on the 3rd collection sheet (31) and collect window (31-1), be bonded with on one side of the 3rd collection sheet (31) greater than the 3rd of the 3rd collection window (31-1) area size and collect carrier (32), have second through hole (9-1) on the second collection carrier (9); Collecting sheet (6), second first collects under sheet (10) and the 3rd collection sheet (31) folded state, the position of first through hole (8-1), second through hole (9-1) and the 3rd collection carrier (32) and the 3rd collection window (31-1) is corresponding, and wherein second through hole (9-1) is less than first through hole (8-1).
8, sample collection according to claim 7 and pick-up unit, it is characterized in that: described test card (28) mainly comprises sheet (19) under test card last slice (12) and the test card, between the two by impression (15) interconnection, wherein test card last slice (12) is provided with three groups of dripping holes and results window, sheet under the test card (19) is provided with the same number of test-strips with dripping hole and the corresponding position of results window, and the spacing of collecting carrier in the spacing of test-strips and the collector cards (27) adapts.
9, a kind of collection of detected sample and detection method is characterized in that: mainly may further comprise the steps and realize:
1), opens collector cards last slice (1), keep the first collection sheet (6) and second to collect sheet (10) and be in folded state, detected sample is applied in the first collection window of collecting on the sheet (6) (7), the detected sample of a part stays in first and collects on the carrier (8), another part stays on the second collection carrier (9) by first first through hole of collecting on the carrier (8) (8-1), the collector cards last slice (1) that closes is sent to hospital then and detects;
2), the test card last slice (12) of test card (28) is opened sheet (11) under expansion collector cards last slice (1) and the collector cards; Tear the screening glass (2) that is positioned at sheet (11) under collector cards last slice (1) and the collector cards; Allowing collect has the first collection carrier (8) and second of detected sample to collect the sample region of acceptance (19-1) that carrier (9) is close to first test-strips (17) and second test-strips (18) respectively;
3), the sheet (19) under test card last slice (12) and the test card that closes; First dripping hole (14) on test card last slice (12) drips first detectable (22), read testing result from first results window (24), come result of determination according to the change color situation, second dripping hole (26) on test card last slice (12) drips second detectable (23), observe testing result from second results window (25), come result of determination according to the change color situation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024782 CN1266468C (en) | 2004-05-31 | 2004-05-31 | Sample collecting and detecting apparatus, method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410024782 CN1266468C (en) | 2004-05-31 | 2004-05-31 | Sample collecting and detecting apparatus, method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1584559A true CN1584559A (en) | 2005-02-23 |
| CN1266468C CN1266468C (en) | 2006-07-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410024782 Expired - Lifetime CN1266468C (en) | 2004-05-31 | 2004-05-31 | Sample collecting and detecting apparatus, method thereof |
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| Country | Link |
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| CN (1) | CN1266468C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018137527A1 (en) * | 2017-01-25 | 2018-08-02 | 吴智良 | Fecal occult blood test pad |
| CN109115753A (en) * | 2017-06-22 | 2019-01-01 | 吴智良 | Occult blood test device and method |
-
2004
- 2004-05-31 CN CN 200410024782 patent/CN1266468C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018137527A1 (en) * | 2017-01-25 | 2018-08-02 | 吴智良 | Fecal occult blood test pad |
| CN109115753A (en) * | 2017-06-22 | 2019-01-01 | 吴智良 | Occult blood test device and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1266468C (en) | 2006-07-26 |
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