CN1583120A - Capsules for nourshing kidney and strengthening yang and their preparation - Google Patents
Capsules for nourshing kidney and strengthening yang and their preparation Download PDFInfo
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- CN1583120A CN1583120A CNA2004100449869A CN200410044986A CN1583120A CN 1583120 A CN1583120 A CN 1583120A CN A2004100449869 A CNA2004100449869 A CN A2004100449869A CN 200410044986 A CN200410044986 A CN 200410044986A CN 1583120 A CN1583120 A CN 1583120A
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Abstract
A Chinese medicine in the form of capsule for reinforcing vital energy of kidney, invigorating Yang, and improving sexual function is prepared from through 6 Chinese-medicinal materials including pilose antler, ginseng, rehmannia root, bull penis, etc through extracing in water and/or alcohol or pulverizing, mixing loading in capsules.
Description
One, technical field
The present invention relates to a kind of kidney invigorating and YANG supporting health product and preparation method thereof of mainly processing, specifically a kind of capsule for nourishing kidney and strengthening Yang and preparation method thereof by Chinese crude drug.
Two, background technology
The traditional Chinese medical science thinks that kidney is very important organ in people's life process, the obstacle of people's numerous disease such as sexual function aspect etc. are all closely related with the function of kidney.There is the herbal species of kidney invigorating and YANG supporting effect a lot, ancient prescription, patent medicine are also arranged, apply for the also a lot of of Chinese patent, as the compositions and the preparation thereof that contain Herba Epimedii just have more than 300, the powder of beating that has is used as medicine, and the extraction active component that has is used as medicine etc., but does not have capsule in many preparations.
Three, summary of the invention
Technical scheme of the present invention is that the vegetable Chinese herbal medicine active component (extract) of water and/or alcohol extraction is processed into capsule with the special auxilliary adjuvant that pharmaceutics allowed of animal Chinese crude drug powder.Described Chinese medicine has following component and parts by weight:
15～35 parts of 15～35 portions of Testis Et penis Bovis seu Bubali of 1 part of Radix Ginseng of Cornu Cervi Pantotrichum
90～135 parts of 25～40 parts of Herba Epimedii of 15～35 parts of Radix Rehmanniae Preparata of Penis et testis canitis
Preferred parts by weight are:
20～30 parts of 20～30 portions of Testis Et penis Bovis seu Bubali of 1 part of Radix Ginseng of Cornu Cervi Pantotrichum
100～125 parts of 30～35 parts of Herba Epimedii of 20～30 parts of Radix Rehmanniae Preparata of Penis et testis canitis.
Testis Et penis Bovis seu Bubali, Penis et testis canitis are processed into Powdered being used as medicine, and the extract of other component waters and/or alcohol is used as medicine.The mixed extract of preferred water extract and alcohol extract is used as medicine.
Testis Et penis Bovis seu Bubali can replace with the Testis Et penis Equi of equivalent.
In above-mentioned component also to add vitamin B
1And/or vitamin B
6And/or vitamin C each 2 parts, 2 parts, 10 parts.
Preparation of the present invention comprises the preparation and the capsular processing of raw material, and feedstock production comprises following process:
1, with organizing pulverizer to rub, it is standby to be ground into powder after the drying again after chilled storage for Testis Et penis Bovis seu Bubali, Penis et testis canitis.Perhaps standby with being ground into powder again after traditional parch method parch.If add one parch of Concha Arcae, the Testis Et penis Bovis seu Bubali powder, the Penis et testis canitis powder effect that obtain like this are better during parch.
2, Cornu Cervi Pantotrichum, Radix Ginseng, Radix Rehmanniae Preparata Herba Epimedii are used water extraction 2～4 times earlier, merge water and propose liquid, and dehydration concentrates and obtains water extract, the crude drug reuse ethanol extraction after water is carried 2～4 times, and the merging ethanol extract, the decompression precipitation reclaims ethanol, obtains extract.
3, method processing capsule routinely.Can mix after slag charge after extracting of Cornu Cervi Pantotrichum, Radix Ginseng, drying, the pulverizing in other adjuvants when adjuvant and use.
The present invention all extracts water miscible in the vegetable Chinese herbal medicine and liposoluble active component and is used, both having helped human body draws, conveniently again increase dosage, and Cornu Cervi Pantotrichum, the Radix Ginseng slag charge after extracting makes full use of again, this is very favourable to improving curative effect.
This capsule has carried out the medicine teaching test by pharmacology teaching and research room of Wannan Medical College, and conclusion is as follows:
1, yang invigorating functions:
Normal mouse and castrated rats, the test of sexual organ and accessory sex gland weight method: this medicine gastric infusion,---weight of Seminal vesicle also makes castrated rats seminal fluid capsule---prostate weightening finish that can improve normal mouse testis, prostate, when heavy dose of more very.
The microelectrode stimulus method: stimulation in rats penis, this capsule can make it erect rapidly, and the persistent period prolongs.
Above-mentioned this capsule of binomial description of test can promote the growth promoter of sexual organ and accessory sex gland, sexual function improving.
2, the kidney invigorating effect
Swimming with a load attached to the body experiment of insufficiency of kidney-YANG mice and the test of adrenal gland's weight method: this capsule can prolong the insufficiency of kidney-YANG mice swimming with a load attached to the body time, low dose just can alleviate adrenal atrophy phenomenon, then can make adrenal gland's weight keep normal level when heavy dose of, it serves to show that this product has the effect of resisting fatigue and anti-insufficiency of kidney-YANG.
3, to the influence of animal mating ability
The result that male and female (4: 1) rat mates mating test shows that this capsule can shorten copulation and dive the phase of paying, and increases and catches number, improves the occurrence rate of the cloudy bolt of female Mus, proves the useful essence of this product, supporing yang effect.
4, short sex hormone function
Neuter preputial glands weight method and radioimmunology analysis method are surveyed hormonal readiness, and test shows that this capsule can improve castrated rats blood plasma testosterone level, increase actual tare, prove to have androgenic effect.
This capsule carries out clinical trial by Nanjing Military Command of PLA hospital general, and 27 examples are organized in treatment, matched group (obeying commercially available NANBAO) 20 examples.Administration 3 times/day, 2/time, serve on 30 days.Do inspections such as sexual function, blood, urine, gonadal hormone before and after taking medicine, and observe the variation of pulse condition, tongue fur.
Recovery from illness: pulse condition, tongue fur recover normal, and the sexual life success is more than 5 minutes, and is sexy good.5 examples are organized in treatment, and matched group does not have.
Produce effects: pulse condition, tongue fur are clearly better, and sexual life can be successful, more than 3 minutes.7 examples are organized in treatment, and matched group does not have.
Effectively: pulse condition, tongue fur take a turn for the better, and sexual life is success reluctantly, and the time is short, and 7 examples are organized in treatment, matched group 11 examples.
Invalid: other index no changes, penis anorthosis.8 examples are organized in treatment, matched group 9 examples.
This capsule total effective rate is 70.3%, is higher than 55% of matched group.
Four, concrete mode
Below simple and clear for narration, it is A, B, C, D, E, F that Cornu Cervi Pantotrichum, Radix Ginseng, Testis Et penis Bovis seu Bubali, Penis et testis canitis, Radix Rehmanniae Preparata and Herba Epimedii are specified code name successively.
Non-limiting examples is described below:
1, get A1 part, decoct with water four times (adding water 10,8,6,5 times of amounts successively), preceding twice each 2 hours, back twice each 1.5 hours merged four filtrates, and dehydration concentrates, and obtains water extract extractum.Filtering residue merges four times filtrate with each 2 hours of 80% alcohol reflux four times (ethanol is followed successively by 8,6,4,3 times of amounts), and ethanol is reclaimed in distilling under reduced pressure, obtains ethanol extraction extractum.Two kinds of extractum are standby.Perhaps, two kinds of filtrates are merged one concentrate, ethanol is reclaimed in first here distilling under reduced pressure, and dehydration concentrates again, and it is standby to obtain mixing extractum.
Get B15 part, water and 80% ethanol extraction are four times respectively, and operation is with the extraction of A, and two kinds of extractum mentioning B are standby, and it is standby perhaps to mix extractum.
Get each 20 parts of C and D, remove dud, clean draining is cut into 17 li rice sections, cleans with distilled water, puts into cabinet cold preservation three days, and with organizing the broken machine dumpling of dumpling broken, lyophilization is ground into powder again, and is standby after getting.
Get each 25 parts and 100 parts of E and F, mix back water and 80% ethanol and extract respectively three times, extract and operate same A, obtain E, F and water, two kinds of extractum of ethanol are standby, it is standby perhaps to mix extractum.
C and D also can followingly process: remove to brush lightly dud, clean and to drain, be cut into 12 li rice sections, with Concha Arcae, one parch of Pulvis Talci is till C and D can pulverize.Get C and D is ground into powder, standby.
2, get A1 part, B20 part, C25 part, D25 part, E30 part, F125 part.
A, B, C, D, E, F extract are processed with embodiment 1.Standby.
3, get A1 part, B30 part, C30 part, D35 part, E35 part, F135 part, processing is with embodiment 1 or implement 2.
4, the filter residue and drying of A and B is pulverized, mixed mix homogeneously in the microcrystalline cellulose excipients, standby.
5, be example respectively with embodiment 2 to standby material, the processing capsule.
With C and D powder and VB
1, VB
2With each 2 parts, 2 parts, 10 parts of VC, mix homogeneously, one mix homogeneously of preservative sodium benzoate that can add ormal weight obtains mixed powder.
With microcrystalline cellulose excipients, two kinds of extract extractum of A, B, C, D, E, F or mix extractum and the abundant mix homogeneously of above-mentioned mixed powder are granulated, and 14 mesh sieve granulate are crossed in dry back, adorn 1 at last
#Capsule, every capsules include imitates composition 0.2～0.25g.
6, this compositions can also be processed into soft capsule.
Claims (5)
1, a kind of capsule for nourishing kidney and strengthening Yang comprises the adjuvant that allows on extract, animal Chinese drugs powder and the pharmaceutics of vegetable Chinese herbal medicine water and/or alcohol, and it is characterized in that: described Chinese medicine has following component and parts by weight,
15～35 parts of 15～35 portions of Testis Et penis Bovis seu Bubali of 1 part of Radix Ginseng of Cornu Cervi Pantotrichum
90～135 parts of 25～40 parts of Herba Epimedii of 15～35 parts of Radix Rehmanniae Preparata of Penis et testis canitis.
2, capsule for nourishing kidney and strengthening Yang according to claim 1 is characterized in that: preferred following weight fraction,
20～30 parts of 20～30 portions of Testis Et penis Bovis seu Bubali of 1 part of Radix Ginseng of Cornu Cervi Pantotrichum
100～125 parts of 30～35 parts of Herba Epimedii of 20～30 parts of Radix Rehmanniae Preparata of Penis et testis canitis.
3, capsule for nourishing kidney and strengthening Yang according to claim 1 and 2 is characterized in that: also contain vitamin B in the capsule
1And/or vitamin B
6And/or vitamin V c each 2 parts, 2 parts, 10 parts.
4, by the preparation method of the described capsule for nourishing kidney and strengthening Yang of claim 1, comprise the preparation and the capsular processing of raw material, it is characterized in that: described feedstock production is:
(1) 15～35 portion of Testis Et penis Bovis seu Bubali and 15～35 parts of Penis et testis canitis are cleaned the back chilled storage, take out with organizing pulverizer to rub, and pulverize after the drying again and obtain powder; Pulverize again after the parch of perhaps traditional parch method and obtain powder;
(2) 1 parts of Cornu Cervi Pantotrichums, 15～35 parts of Radix Ginsengs, 25～40 parts of Radix Rehmanniae Preparata, 90～135 parts of Herba Epimedii be water and ethanol extraction 2～4 times respectively, obtain aqueous extract and ethanol extract, perhaps concentrate the extract extractum that obtains separately separately, perhaps two kinds of extracting solution are mixed, ethanol is reclaimed in distilling under reduced pressure, and dehydration concentrates and obtains mixed extract extractum again.
5, by the preparation method of the described capsule for nourishing kidney and strengthening Yang of claim 4, it is characterized in that: when parch prepares Testis Et penis Bovis seu Bubali, Penis et testis canitis powder, with the Concha Arcae parch.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100449869A CN1298353C (en) | 2004-06-05 | 2004-06-05 | Capsules for nourshing kidney and strengthening yang and their preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100449869A CN1298353C (en) | 2004-06-05 | 2004-06-05 | Capsules for nourshing kidney and strengthening yang and their preparation |
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| Publication Number | Publication Date |
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| CN1583120A true CN1583120A (en) | 2005-02-23 |
| CN1298353C CN1298353C (en) | 2007-02-07 |
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| CNB2004100449869A Expired - Fee Related CN1298353C (en) | 2004-06-05 | 2004-06-05 | Capsules for nourshing kidney and strengthening yang and their preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103549430A (en) * | 2013-11-11 | 2014-02-05 | 吉林省和升圆生物科技有限公司 | Compound pure ginseng and pilos antler powder lozenge as well as production process thereof |
| CN104736150A (en) * | 2012-08-20 | 2015-06-24 | "Parafarm"有限责任公司 | Method for restoring male sex drive (libido) using a food supplement for restoring male sex drive (libido) |
| CN105769913A (en) * | 2016-03-22 | 2016-07-20 | 吉林省标达科技有限责任公司 | Method of extracting active substance in Cornu cervi pantotrichum |
| CN108452106A (en) * | 2017-02-20 | 2018-08-28 | 姚洪文 | A kind of medea and preparation method thereof that kidney tonifying fills blood |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072260C (en) * | 1997-08-20 | 2001-10-03 | 周忠泉 | SOD health-care nourishing wine suitable for both man and woman |
| CN1121866C (en) * | 2000-08-18 | 2003-09-24 | 焦更海 | Chinese medicine for treating man's sexual disfunction and its preparing process |
-
2004
- 2004-06-05 CN CNB2004100449869A patent/CN1298353C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104736150A (en) * | 2012-08-20 | 2015-06-24 | "Parafarm"有限责任公司 | Method for restoring male sex drive (libido) using a food supplement for restoring male sex drive (libido) |
| CN104736150B (en) * | 2012-08-20 | 2017-09-08 | "Parafarm"有限责任公司 | The method that man's sexual desire (Libido) is restored is realized using the dietary supplements of man's sexual desire (Libido) recovery effect |
| CN103549430A (en) * | 2013-11-11 | 2014-02-05 | 吉林省和升圆生物科技有限公司 | Compound pure ginseng and pilos antler powder lozenge as well as production process thereof |
| CN105769913A (en) * | 2016-03-22 | 2016-07-20 | 吉林省标达科技有限责任公司 | Method of extracting active substance in Cornu cervi pantotrichum |
| CN108452106A (en) * | 2017-02-20 | 2018-08-28 | 姚洪文 | A kind of medea and preparation method thereof that kidney tonifying fills blood |
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| Publication number | Publication date |
|---|---|
| CN1298353C (en) | 2007-02-07 |
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Application publication date: 20050223 Assignee: Wuhu Bojing medical Limited by Share Ltd Assignor: Zhou Yaosheng Contract record no.: 2010340000062 Denomination of invention: Capsules for nourshing kidney and strengthening yang and their preparation Granted publication date: 20070207 License type: Exclusive License Record date: 20100420 |
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Owner name: WUHU BRAN PHARMACUTICAL CO., LTD. Free format text: FORMER OWNER: ZHOU YAOSHENG Effective date: 20100702 |
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Effective date of registration: 20120816 Address after: 241000 Anhui province Wuhu City Jiuhua Road biological pharmaceutical science & Technology Park 181 Patentee after: Wuhu Boying pharmaceutical Technology Co., Ltd. Address before: 241000 Anhui city of Wuhu province Wuhu Bojing medical Limited by Share Ltd Zheshan Road Patentee before: Wuhu Bojing medical Limited by Share Ltd |
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