CN1583005A - External used medicines for Hong Kong foot and tinea manuum - Google Patents
External used medicines for Hong Kong foot and tinea manuum Download PDFInfo
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- CN1583005A CN1583005A CN 200410019479 CN200410019479A CN1583005A CN 1583005 A CN1583005 A CN 1583005A CN 200410019479 CN200410019479 CN 200410019479 CN 200410019479 A CN200410019479 A CN 200410019479A CN 1583005 A CN1583005 A CN 1583005A
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Abstract
An exterior-applied medicine in the form of orange suspension for treating tinea manuum and tinea pedis is prepared from 5 Chinese-medicinal materials including stemona root, cnidium fruit, flavescent sophora root, etc through immersing in alcohol, filtering, proportionally mixing with benzoic acid, bagodryl hydrochloride and camphor.
Description
Technical field
The present invention relates to a kind of external used medicine for the treatment of the tinea pedis and the tinea manuum.
Background technology
The tinea pedis and the tinea manuum are a kind of common skin diseases, and the tinea pedis popular name is " beriberi ", and tinea manuum popular name is " fungal infection of hand and foot ".The external used medicine for the treatment of the tinea pedis and the tinea manuum at present on the market is a lot, and these external used medicines are cured tinea pedis and the tinea manuum time is long, cure the patient with slight symptoms and need 10 days at least, cure the patient with severe symptoms and need 30 days at least, the tinea pedis and the tinea manuum are cured back relapse rate height, and the patient's i.e. recurrence in 15～20 days after healing more than 70% is arranged.
Summary of the invention
Technical problem to be solved by this invention provides a kind of healing tinea pedis and tinea manuum time weak point, and the tinea pedis and the tinea manuum are cured the low treatment tinea pedis of back relapse rate and the external used medicine of the tinea manuum.
External used medicine of the present invention, by following component, count 10～50 parts of Cortex Pseudolaricis, 10～30 parts of the Radixs Stemonae by weight, 10～50 parts of Fructus Cnidiis, 10～30 parts of Radix Sophorae Flavescentiss, 10～50 portions of soaks after 350～600 parts of immersions of ethanol of Radix Rumicis, 10～60 parts in benzoic acid, 5～10 parts of diphhydramine hydrochlorides, the orange-yellow suspension body of 10～60 parts of formations of Camphora.
The preparation method of the external used medicine of the treatment tinea pedis and the tinea manuum is as follows:
(1), with the solid benzoic acid, cross 200 mesh sieves behind diphhydramine hydrochloride and the Camphora pulverize separately, standby;
(2), take by weighing each component drug by drug ratio;
(3), with Cortex Pseudolaricis, the Radix Stemonae, Fructus Cnidii, Radix Sophorae Flavescentis and Radix Rumicis are put into and are filled alcoholic acid nonmetallic vessel and soak 7～15 days after-filtration, the ethanol medicinal liquid after the filtration is standby;
(4), with benzoic acid, diphhydramine hydrochloride and Camphora are finished product after putting into ethanol medicinal liquid mixing and stirring, the medicine finished product after making is put into special-purpose air-tight bottle deposit.
Medicine of the present invention is orange-yellow suspension body, and after leaving standstill, solid particle sinks, and top is orange-yellow transparency liquid, need shake up during use.The effect duration of medicine of the present invention is 3 years.
It is short that the cured substance tinea pedis of the present invention and the tinea manuum have the time, and the tinea pedis and the tinea manuum are cured the low characteristics of back relapse rate.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment.
Embodiment 1
1, component medicine
(1), Cortex Pseudolaricis: Chinese medicine commercially available product, (2), the Radix Stemonae: Chinese medicine commercially available product, (3), Fructus Cnidii: Chinese medicine commercially available product, (4), Radix Sophorae Flavescentis: Chinese medicine commercially available product, (5), Radix Rumicis: Chinese medicine commercially available product, (6), ethanol: pharmaceutical grade (50%～95%) ethanol, (7), benzoic acid: medicinal commercially available product, (8), Camphora diphhydramine hydrochloride: medicinal commercially available product, 9): medicinal commercially available product.
2, medicine compositing formula is counted by weight,
Cortex Pseudolaricis 13 Radixs Stemonae 10 Fructus Cnidiis 13 Radix Sophorae Flavescentiss 10 Radix Rumiciss 13 ethanol 350
Benzoic acid 15 diphhydramine hydrochlorides 6 Camphoras 15
3, medicine preparation
(1), with the solid benzoic acid, cross 200 mesh sieves behind diphhydramine hydrochloride and the Camphora pulverize separately, standby;
(2), take by weighing each component drug in the component drug ratio;
(3), with Cortex Pseudolaricis, the Radix Stemonae, Fructus Cnidii, Radix Sophorae Flavescentis and Radix Rumicis are put into and are filled alcoholic acid nonmetallic vessel and soak 7～15 days after-filtration, the ethanol medicinal liquid after the filtration is standby;
(4), with benzoic acid, diphhydramine hydrochloride and Camphora are finished product after putting into ethanol medicinal liquid mixing and stirring.Medicine finished product after making is put into special-purpose air-tight bottle to be deposited.
4, clinical practice test
I, tinea pedis clinical practice test
(1), case load: 268 examples, man: 160 examples, patient with slight symptoms: 95 examples, patient with severe symptoms: 65 examples;
Woman: 108 examples, patient with slight symptoms: 68 examples, patient with severe symptoms's 40 examples;
The patient age scope is 14～50 years old.
(2), symptom
Be divided into four types clinically, but often mix exist simultaneously and based on a certain type.
Hyperkeratotic pattern: skin lesion is coarse owing to hyperkeratosis causes pachyderma.Often chap and pain winter.
The vesicle type: vesicle is positioned at the vola, bleb wall thickness and being not easy brokenly, and content is transparent.In groups or be dispersed in distribution.The vesicle surrounding skin is normal.Bleb liquid absorbs and dry desquamation after a few days.Then become pustule as the secondary bacterial infection.Pruritus is often arranged.
The dipping erosive type: skin lesion place skin is macerated and is bleached through moisture, wipe epidermis after, expose red rotten to the corn face, good sending out between third and fourth toe.
The pimple squama type: skin lesion is positioned at vola, sufficient edge and heel etc. and locates.Show as erythema and pimple, there is tangible strip desquamation on the surface, and summer, vesicle can take place.
(3), Therapeutic Method
Clean airing behind the affected part, the medicinal liquid in the air-tight bottle is shaken up back dipping in medical hairbrush or cotton swab get an amount of medicinal liquid, by the inboard coating in affected part lateral.Every day coating once, until curing or symptom does not have obvious improvement.Each coating method as previously mentioned.
(4), efficacy assessment standard
A, healing: symptom and sign disappear, and it is normal that skin recovers.
B, improvement: symptom obviously alleviates, and skin lesion disappears more than 50%.The check fungus still has the positive.
C, do not heal: symptom, Signs do not have change.
D, untoward reaction: behind the coating, pars affecta skin occurs red and swollen, suppurates erosion.
(5), therapeutic outcome sees Table 1
Table 1 tinea pedis therapeutic outcome
| Treatment time (my god) | ?????????????5 | ?????????????9 | ???????????????14 | ||||||
| Therapeutic effect | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal |
| Man's (example) | ??95 | ??60 | ??5 | ??122 | ??38 | ??0 | ??150 | ??10 | ??0 |
| Woman's (example) | ??68 | ??38 | ??2 | ??77 | ??31 | ??0 | ??102 | ??6 | ??0 |
| Percentage rate (%) | ??60.82 | ??36.57 | ??2.61 | ??74.25 | ??25.75 | ??0 | ??94.03 | ??5.97 | ??0 |
| Untoward reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
By table 1 as seen, treat after 5 days, tinea pedis patient with slight symptoms all cures, and cure rate reaches 60.82%; After 9 days, a part of patient with severe symptoms cures, and total cure rate reaches 74.25%; After 14 days, the patient with severe symptoms obviously reduces, and total cure rate reaches 94.03%.Check after 1 year, the person's of recovering relapse rate is 20%.
II, tinea manuum clinical practice test
(1), case load: 78 examples, man: 43 examples, patient with slight symptoms: 23 examples, patient with severe symptoms: 20 examples;
Woman: 35 examples, patient with slight symptoms: 18 examples, patient with severe symptoms: 17 examples;
The patient age scope is 14～50 years old.
(2), symptom
Skin lesion and tinea pedis are roughly the same.How since a side hands, ill as both hands, the hands state of an illness of morbidity is heavier earlier.Skin lesion is mainly vesicle type and keratinization type.Winter, the pars affecta skin chap was thick, easily chapped.Vesicle can take place in summer, the normal eckband shape desquamation that forms in the back of breaking.Pruritus is often arranged.The course of disease is chronic, can not heal for many years.
(3), the same tinea pedis of Therapeutic Method
(4), efficacy assessment standard
A, healing: symptom, sign disappear, and it is normal that skin recovers.Check fungus continuous quadratic feminine gender.
B, improvement: symptom obviously alleviates, and skin lesion disappears more than 50%.The check fungus is negative or positive.
C, do not heal: clinical symptoms, Signs do not have change.
D, untoward reaction: behind the coating, pars affecta skin occurs red and swollen, suppurates erosion.
(5), therapeutic outcome sees Table 2
Table 2 tinea manuum therapeutic outcome
| Treatment time (my god) | ??????????????5 | ?????????????9 | ?????????????14 | ||||||
| Therapeutic effect | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal |
| Man's (example) | ??23 | ??16 | ??4 | ??36 | ??4 | ??3 | ??40 | ??2 | ??1 |
| Woman's (example) | ??18 | ??15 | ??2 | ??23 | ??11 | ??1 | ??34 | ??1 | ??0 |
| Percentage rate (%) | ??52.56 | ??39.74 | ??7.69 | ??75.64 | ??19.23 | ??5.13 | ??94.87 | ??3.85 | ??1.28 |
| Untoward reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
By table 2 as seen, treat after 5 days, tinea manuum patient with slight symptoms all cures, and cure rate reaches 52.56%; After 9 days, a part of patient with severe symptoms cures, and total cure rate reaches 75.64%; After 14 days, the patient with severe symptoms obviously reduces, and total cure rate reaches 94.87%.Check after 1 year, the person's of recovering relapse rate is 17%.
Embodiment 2
1, the component medicine is with embodiment 1
2, medicine compositing formula is counted by weight,
Cortex Pseudolaricis 35 Radixs Stemonae 18 Fructus Cnidiis 35 Radix Sophorae Flavescentiss 18 Radix Rumiciss 35 ethanol 480
Benzoic acid 40 diphhydramine hydrochlorides 7 Camphoras 40
3, the medicine preparation is with embodiment 1
4, clinical practice test
I, tinea pedis clinical practice test
(1), case load: 477 examples, man: 203 examples, patient with slight symptoms: 108 examples, patient with severe symptoms: 95 examples;
Woman: 274 examples, patient with slight symptoms: 146 examples, patient with severe symptoms: 128 examples;
The patient age scope is 14～50 years old.
(2), symptom is with embodiment 1
(3), Therapeutic Method is with embodiment 1
(4), efficacy assessment standard is with embodiment 1
(5), therapeutic outcome sees Table 3
Table 3 tinea pedis therapeutic outcome
| Treatment time (my god) | ??????????????5 | ??????????????9 | ???????????????14 | ||||||
| Therapeutic effect | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal |
| Man's (example) | ??108 | ??85 | ??10 | ??176 | ??25 | ??2 | ??195 | ??8 | ????0 |
| Woman's (example) | ??146 | ??102 | ??26 | ??228 | ??39 | ??7 | ??268 | ??5 | ????1 |
| Percentage rate (%) | ??53.25 | ??39.20 | ??7.55 | ??84.70 | ??13.42 | ??1.89 | ??97.06 | ??2.73 | ????0.21 |
| Untoward reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
By table 3 as seen, treat after 5 days, tinea pedis patient with slight symptoms all cures, and cure rate reaches 53.25%; After 9 days, a part of patient with severe symptoms cures, and total cure rate reaches 84.70%; After 14 days, the patient with severe symptoms obviously reduces, and total cure rate reaches 97.06%.Check after 1 year, the person's of recovering relapse rate is 15%.
II, tinea manuum clinical practice test
(1), case load: 153 examples, man: 95 examples, patient with slight symptoms: 50 examples; Patient with severe symptoms: 45 examples;
Woman: 58 examples, patient with slight symptoms: 36 examples; Patient with severe symptoms: 22 examples;
The patient age scope is 14～50 years old.
(2), symptom is with embodiment 1
(3), Therapeutic Method is with embodiment 1
(4), efficacy assessment standard is with embodiment 1
(5), therapeutic outcome sees Table 4
Table 4 tinea manuum therapeutic outcome
| Treatment time (my god) | ?????????????5 | ?????????????9 | ?????????????14 | ||||||
| Therapeutic effect | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal |
| Man's (example) | ??50 | ??35 | ??10 | ??68 | ??24 | ??3 | ??91 | ??3 | ??1 |
| Woman's (example) | ??36 | ??19 | ??3 | ??42 | ??15 | ??1 | ??58 | ??0 | ??0 |
| Percentage rate (%) | ??56.21 | ??35.29 | ??8.50 | ??71.90 | ??25.49 | ??2.61 | ??97.39 | ??1.96 | ??0.65 |
| Untoward reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
By table 4 as seen, treat after 5 days, tinea manuum patient with slight symptoms all cures, and cure rate reaches 56.21%; After 9 days, a part of patient with severe symptoms cures, and total cure rate reaches 71.90%; After 14 days, the patient with severe symptoms obviously reduces, and total cure rate reaches 97.39%.Check after 1 year, the person's of recovering relapse rate is 13%.
Embodiment 3
1, the component medicine is with embodiment 1
2, medicine compositing formula is counted by weight,
Cortex Pseudolaricis 50 Radixs Stemonae 30 Fructus Cnidiis 50 Radix Sophorae Flavescentiss 30 Radix Rumiciss 50 ethanol 600
Benzoic acid 60 diphhydramine hydrochlorides 10 Camphoras 60
3, the medicine preparation is with embodiment 1
4, clinical practice test
I, tinea pedis clinical practice test
(1), case load: 835 examples, man: 535 examples, patient with slight symptoms: 380 examples, patient with severe symptoms; 155 examples;
Woman: 300 examples, patient with slight symptoms: 203 examples, patient with severe symptoms: 97 examples;
The patient age scope is 14～50 years old.
(2), symptom is with embodiment 1
(3), Therapeutic Method is with embodiment 1
(4), efficacy assessment standard is with embodiment 1
(5), therapeutic outcome sees Table 5
Table 5 tinea pedis therapeutic outcome
| Treatment time (my god) | ?????????????5 | ?????????????9 | ?????????????14 | ||||||
| Therapeutic effect | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal |
| Man's (example) | ??380 | ??144 | ??11 | ??436 | ??93 | ??6 | ??528 | ??7 | ??0 |
| Woman's (example) | ??203 | ??87 | ??10 | ??273 | ??24 | ??3 | ??297 | ??3 | ??0 |
| Percentage rate (%) | ??69.82 | ??27.66 | ??2.51 | ??84.91 | ??14.01 | ??1.08 | ??98.80 | ??1.20 | ??0 |
| Untoward reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
5 as seen by, treat after 5 days, tinea pedis patient with slight symptoms all cures, and cure rate reaches 69.82%; After 9 days, a part of patient with severe symptoms cures, and total cure rate reaches 84.91%; After 14 days, the patient with severe symptoms obviously reduces, and total cure rate reaches 98.80%.Check after 1 year, the person's of recovering relapse rate is 8%.
II, tinea manuum clinical practice test
(1), case load: 316 examples, man: 218 examples, patient with slight symptoms: 102 examples, patient with severe symptoms: 116 examples;
Woman: 98 examples, patient with slight symptoms: 44 examples, patient with severe symptoms: 54 examples;
The patient age scope is 14～50 years old.
(2), symptom is with embodiment 1
(3), Therapeutic Method is with embodiment 1
(4), efficacy assessment standard is with embodiment 1
(5), therapeutic outcome sees Table 6
Table 6 tinea manuum therapeutic outcome
| Treatment time (my god) | ??????????????5 | ?????????????????9 | ????????????14 | ||||||
| Therapeutic effect | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal | Cure | Take a turn for the better | Do not heal |
| Man's (example) | ??102 | ??103 | ??13 | ??157 | ??60 | ????1 | ??215 | ??3 | ??0 |
| Woman's (example) | ??44 | ??42 | ??12 | ??73 | ??25 | ????0 | ??97 | ??1 | ??0 |
| Percentage rate (%) | ??46.20 | ??45.89 | ??7.91 | ??72.78 | ??26.90 | ????0.32 | ??98.73 | ??1.27 | ??0 |
| Untoward reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
6 as seen by, treat after 5 days, tinea manuum patient with slight symptoms all cures, and cure rate reaches 46.20%; After 9 days, a part of patient with severe symptoms cures, and total cure rate reaches 72.78%; After 14 days, the patient with severe symptoms obviously reduces, and total cure rate reaches 98.73%.Check after 1 year, the person's of recovering relapse rate is 8%.
The embodiment explanation, during the external medication patient with slight symptoms of the treatment tinea pedis provided by the invention and the tinea manuum, at most only needed just can all cure in 5 days, during the treatment patient with severe symptoms, except that persistent ailment person, at most only needed just can cure in 14 days, the relapse rate that the tinea pedis and the tinea manuum are cured the person of recovering after 1 year is below 20%, thereby medicine of the present invention has the tinea pedis of healing and the tinea manuum time is short, and the tinea pedis and the tinea manuum are cured the low characteristics of back relapse rate.
Claims (1)
1, a kind of external used medicine for the treatment of the tinea pedis and the tinea manuum, it is characterized in that,, count by weight by following component drug, 10～50 parts of Cortex Pseudolaricis, 10～30 parts of the Radixs Stemonae, 10～50 parts of Fructus Cnidiis, 10～30 parts of Radix Sophorae Flavescentiss, 10～50 portions of soaks after 350～600 parts of immersions of ethanol of Radix Rumicis, 10～60 parts in benzoic acid, 5～10 parts of diphhydramine hydrochlorides, the orange-yellow suspension body of 10～60 parts of formations of Camphora.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410019479 CN1265832C (en) | 2004-06-07 | 2004-06-07 | External used medicines for Hong Kong foot and tinea manuum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410019479 CN1265832C (en) | 2004-06-07 | 2004-06-07 | External used medicines for Hong Kong foot and tinea manuum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1583005A true CN1583005A (en) | 2005-02-23 |
| CN1265832C CN1265832C (en) | 2006-07-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410019479 Expired - Fee Related CN1265832C (en) | 2004-06-07 | 2004-06-07 | External used medicines for Hong Kong foot and tinea manuum |
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| Country | Link |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308027C (en) * | 2005-06-15 | 2007-04-04 | 李德森 | Medicinal formulation for treating skin tinea |
| CN102008673A (en) * | 2010-12-07 | 2011-04-13 | 贾孝荣 | Medicine composition for treating tinea manus and pedis |
| CN102247564A (en) * | 2010-11-29 | 2011-11-23 | 吴克 | Liquid preparation for treating dermatitis, eczema and the like and preparation method thereof |
| CN104127527A (en) * | 2014-07-23 | 2014-11-05 | 宋锦谋 | Pharmaceutical composition for curing beriberi |
| CN104306614A (en) * | 2014-09-30 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine composition for treating tinea pedis and preparation method of traditional Chinese medicine composition |
-
2004
- 2004-06-07 CN CN 200410019479 patent/CN1265832C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308027C (en) * | 2005-06-15 | 2007-04-04 | 李德森 | Medicinal formulation for treating skin tinea |
| CN102247564A (en) * | 2010-11-29 | 2011-11-23 | 吴克 | Liquid preparation for treating dermatitis, eczema and the like and preparation method thereof |
| CN102008673A (en) * | 2010-12-07 | 2011-04-13 | 贾孝荣 | Medicine composition for treating tinea manus and pedis |
| CN102008673B (en) * | 2010-12-07 | 2011-12-07 | 贾孝荣 | Medicine composition for treating tinea manus and pedis |
| CN104127527A (en) * | 2014-07-23 | 2014-11-05 | 宋锦谋 | Pharmaceutical composition for curing beriberi |
| CN104127527B (en) * | 2014-07-23 | 2016-09-21 | 宋锦谋 | A kind of pharmaceutical composition treating tinea pedis |
| CN104306614A (en) * | 2014-09-30 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine composition for treating tinea pedis and preparation method of traditional Chinese medicine composition |
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| Publication number | Publication date |
|---|---|
| CN1265832C (en) | 2006-07-26 |
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