CN1582966A - Preparation of nano pearls powder - Google Patents
Preparation of nano pearls powder Download PDFInfo
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- CN1582966A CN1582966A CNA031538088A CN03153808A CN1582966A CN 1582966 A CN1582966 A CN 1582966A CN A031538088 A CNA031538088 A CN A031538088A CN 03153808 A CN03153808 A CN 03153808A CN 1582966 A CN1582966 A CN 1582966A
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Abstract
A pearl nanoparticle is prepared from pearl through pulverizing by 300-500 meshes, adding deionized water to obtain suspension, and pulverizing in high-pressure homogenizing machine.
Description
Technical field
The invention belongs to the preparation method field of Margarita ultrafine powder, particularly the preparation method of nanometer pearl powder.
Background technology
Margarita is a kind of famous and precious Chinese crude drug, has the effectiveness of the arresting convulsion of calming the nerves, the removing nebula that makes eye bright, removing toxic substances and promoting granulation, also has the effect of defying age, aesthetic health care in addition.Modern science the analysis showed that Margarita contains nearly 20 seed amino acids, 20 various trace elements, porphyrin, vitamin and abundant calcium class.But Margarita has the hybrid nanostructured, and calcium carbonate sandwich one layer thickness of two-layer aragonite structure is several protein layers to tens nano thickness, and this makes Margarita have very high hardness and toughness, processes very difficult.The processing method of tradition Margarita powder, as elutriation and vibromill method, generally at tens microns, the absorption by human body utilization rate is lower for the particle diameter of the Margarita powder of gained, has the research report to show that the absorption by human body utilization rate is below 30%.
People mainly solve the lower problem of utilization rate by the approach of two aspects, and one is the Margarita liquid of producing solubility, and another is to prepare the more nanometer Margarita powder of small particle diameter.As at Chinese publication number being the preparation method that discloses soluble pearl powder in the patent application of CN88105369 and CN1018615, but this method or with sour dissolved pearl powder, perhaps hydrolysis under High Temperature High Pressure has changed prototype structure and the composition of Margarita, can influence the effect of Margarita powder.Disclose the preparation method of nanometer pearl powder in Chinese publication number is the patent application of CN1351869 and CN1416821, but the former needs still earlier with sour dissolved pearl powder, its method has above-mentioned defective equally; The particle size distribution of the Margarita powder of latter's gained too wide (10～1000nm), the particle of the Margarita powder of greater particle size to absorb efficient still lower.
Summary of the invention
Margarita is pulverized in the huge energy field that is produced when the objective of the invention is to utilize Margarita powder to spray the vacuum chamber that enters high pressure homogenizer under extremely high pressure, and the preparation method of the simple nanometer pearl powder of a kind of technology is provided.
The present invention is broken into 300～500 purpose fine powders with Margarita powder earlier, adds the deionized water in 4～19 times of weight portions, makes suspension, places high pressure homogenizer to pulverize pearl suspension again, obtains the Margarita powder of particle diameter in 50～100 nanometers.
The preparation method step of nanometer pearl powder of the present invention comprises:
(1). Margarita is become fine powder with Mechanical Grinding Process;
(2). the Margarita fine powder of step (1) mixed obtaining the Margarita suspension with deionized water;
(3). with the Margarita suspension high pressure homogenize machined of step (2), the particle diameter of Margarita powder reaches 50～100 nanometers in the processing rear suspension liquid;
(4). the Margarita powder suspension drying with after step (3) processing obtains nanometer pearl powder.
Variegated Margarita should be cleaned and remove to the used Margarita of the present invention earlier.Used machinery mill can be ball mill, vibromill or airflow milling.The particle diameter of Margarita powder should be controlled between 300～500 orders after the Mechanical Grinding Process, and the particle diameter of Margarita powder then can't enter the vacuum chamber of high pressure homogenizer greater than 300 orders, and particle diameter is lower than 500 orders then increases production time and cost.
The content of Margarita fine powder should be 5～wt20% in the Margarita suspension of the present invention, and content is lower than 5wt% can reduce working (machining) efficiency, and content is higher than the particle diameter that 20wt% can influence product.
The pressure of high pressure homogenizer of the present invention is 50～150MPa, is preferably 100～150MPa, and the particle diameter of the too low then product of pressure increases, and particle size distribution broadens.
The dry preferred centrifugal spray drying method of Margarita powder suspension of the present invention, rapid draing can reduce the secondary agglomeration of Margarita powder, the narrow diameter distribution of gained Margarita powder, particle diameter is between 50～100nm.
The present invention does not change structure and the composition of Margarita, has improved the utilization rate of Margarita powder, and technology is simple, is easy to suitability for industrialized production, and product is specially adapted to medicine, beauty treatment and healthcare field.
Description of drawings
Fig. 1. the transmission electron microscope photo of the nanometer Margarita powder of the embodiment of the invention 1.
The specific embodiment
Embodiment 1
After Margarita usefulness clear water clean dry, be machined to 300 orders with the dither mill, mix with deionized water then, be mixed with the suspension of 20wt%, the pressure of high pressure homogenizer is set at 100MPa, suspension is joined the charging pond of high pressure homogenizer, automatic feed, to be injected into temperature with the centrifugal spray dryer drying method be in 100 ℃ the hothouse with collecting suspension after the processing, obtains the Margarita powder that particle diameter is 50～100nm.Its transmission electron microscope photo is seen Fig. 1.
Embodiment 2
After Margarita usefulness clear water clean dry, be machined to 400 orders with the dither mill, mix with deionized water then, be mixed with the suspension of 10wt%, the pressure of high pressure homogenizer is set at 120MPa, suspension is joined the charging pond of high pressure homogenizer, automatic feed, to be injected into temperature with the centrifugal spray dryer drying method be in 100 ℃ the hothouse with collecting suspension after the processing, obtains the Margarita powder that particle diameter is 50～80nm.
Embodiment 3
After Margarita usefulness clear water clean dry, be machined to 500 orders with the dither mill, mix with deionized water then, be mixed with the suspension of 5wt%, the pressure of high pressure homogenizer is set at 140MPa, suspension is joined the charging pond of high pressure homogenizer, automatic feed, to be injected into temperature with the centrifugal spray dryer drying method be in 100 ℃ the hothouse with collecting suspension after the processing, obtains the Margarita powder that particle diameter is 50～70nm.
Claims (6)
1. the preparation method of a nanometer pearl powder, it is characterized in that: described method step comprises:
(1). Margarita is become fine powder with Mechanical Grinding Process;
(2). the Margarita fine powder of step (1) mixed obtaining the Margarita suspension with deionized water;
(3). with the Margarita suspension high pressure homogenize machined of step (2), the particle diameter of Margarita powder reaches 50～100 nanometers in the processing rear suspension liquid;
(4). the Margarita powder suspension drying with after step (3) processing obtains nanometer pearl powder.
2. the method for claim 1, it is characterized in that: the particle diameter of Margarita powder is 300～500 orders after the described Mechanical Grinding Process.
3. the method for claim 1, it is characterized in that: the content of Margarita fine powder is 5～20wt% in the described Margarita suspension.
4. the method for claim 1, it is characterized in that: the pressure of described high pressure homogenizer is 50～150MPa.
5. method as claimed in claim 4 is characterized in that: the pressure of described high pressure homogenizer is 100～150MPa.
6. the method for claim 1, it is characterized in that: the drying of described Margarita powder suspension is the centrifugal spray drying method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031538088A CN1268312C (en) | 2003-08-22 | 2003-08-22 | Preparation of nano pearls powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031538088A CN1268312C (en) | 2003-08-22 | 2003-08-22 | Preparation of nano pearls powder |
Publications (2)
| Publication Number | Publication Date |
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| CN1582966A true CN1582966A (en) | 2005-02-23 |
| CN1268312C CN1268312C (en) | 2006-08-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031538088A Expired - Fee Related CN1268312C (en) | 2003-08-22 | 2003-08-22 | Preparation of nano pearls powder |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100388981C (en) * | 2005-05-12 | 2008-05-21 | 浙江长生鸟珍珠生物科技有限公司 | Method for preparing full natural Nano pearl powder |
| CN100425245C (en) * | 2006-01-17 | 2008-10-15 | 李伊为 | A method for preparing nano-grade pure pearl powder |
| CN1785153B (en) * | 2005-12-06 | 2010-04-21 | 青岛大学 | Nano-grade material preparation apparatus, and method for preparing nano-anti-oxidation active poly peptide medicine |
| CN101199551B (en) * | 2006-12-15 | 2010-12-08 | 均记贸易有限公司 | Preparing method of pearl powder and products thereof |
| CN101058901B (en) * | 2006-04-07 | 2011-01-12 | 北京同道和诚科技发展有限公司 | Nano pearl polypropylene superfine Denier fibre and preparation method thereof |
| CN101961350A (en) * | 2010-10-28 | 2011-02-02 | 浙江欧诗漫集团德清生物科技有限公司 | Preparation method of fishy smell-removed pearl powder |
| CN102744136A (en) * | 2012-07-13 | 2012-10-24 | 四川厚德医药科技有限公司 | Preparation method for nanometre pearl powder |
| CN104161773A (en) * | 2013-05-16 | 2014-11-26 | 北海市弘健科技发展有限公司 | Preparation method of fully active component nano pearl powder |
| CN104905242A (en) * | 2014-03-14 | 2015-09-16 | 浙江欧诗漫生物股份有限公司 | A method for preparing pearl separated pearl soluble edible calcium and pearl compound whitening factor solution |
| CN105456034A (en) * | 2014-09-12 | 2016-04-06 | 北京瑞芬生物科技有限公司 | Equipment for preparing ginseng extract nanopowder |
| CN105878020A (en) * | 2015-01-10 | 2016-08-24 | 宁波荣辉生物科技有限公司 | Preparation method of nano powder of non-metallic organic material |
| CN106619727A (en) * | 2016-11-28 | 2017-05-10 | 湖州珍露生物制品有限公司 | Pearl powder and preparation method thereof |
| CN109364009A (en) * | 2018-11-03 | 2019-02-22 | 江苏贝塔仕生物科技有限公司 | A kind of formula containing pearl powder beauty |
-
2003
- 2003-08-22 CN CNB031538088A patent/CN1268312C/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100388981C (en) * | 2005-05-12 | 2008-05-21 | 浙江长生鸟珍珠生物科技有限公司 | Method for preparing full natural Nano pearl powder |
| CN1785153B (en) * | 2005-12-06 | 2010-04-21 | 青岛大学 | Nano-grade material preparation apparatus, and method for preparing nano-anti-oxidation active poly peptide medicine |
| CN100425245C (en) * | 2006-01-17 | 2008-10-15 | 李伊为 | A method for preparing nano-grade pure pearl powder |
| CN101058901B (en) * | 2006-04-07 | 2011-01-12 | 北京同道和诚科技发展有限公司 | Nano pearl polypropylene superfine Denier fibre and preparation method thereof |
| CN101199551B (en) * | 2006-12-15 | 2010-12-08 | 均记贸易有限公司 | Preparing method of pearl powder and products thereof |
| CN101961350A (en) * | 2010-10-28 | 2011-02-02 | 浙江欧诗漫集团德清生物科技有限公司 | Preparation method of fishy smell-removed pearl powder |
| CN101961350B (en) * | 2010-10-28 | 2012-05-30 | 浙江欧诗漫集团德清生物科技有限公司 | Preparation method of fishy smell-removed pearl powder |
| CN102744136B (en) * | 2012-07-13 | 2014-04-30 | 四川厚德医药科技有限公司 | Preparation method for nanometre pearl powder and prepared nanometer pearl powder |
| CN102744136A (en) * | 2012-07-13 | 2012-10-24 | 四川厚德医药科技有限公司 | Preparation method for nanometre pearl powder |
| CN104161773A (en) * | 2013-05-16 | 2014-11-26 | 北海市弘健科技发展有限公司 | Preparation method of fully active component nano pearl powder |
| CN104905242A (en) * | 2014-03-14 | 2015-09-16 | 浙江欧诗漫生物股份有限公司 | A method for preparing pearl separated pearl soluble edible calcium and pearl compound whitening factor solution |
| CN105456034A (en) * | 2014-09-12 | 2016-04-06 | 北京瑞芬生物科技有限公司 | Equipment for preparing ginseng extract nanopowder |
| CN105456034B (en) * | 2014-09-12 | 2021-12-24 | 北京瑞芬生物科技股份有限公司 | Equipment for preparing ginseng extract nanopowder |
| CN105878020A (en) * | 2015-01-10 | 2016-08-24 | 宁波荣辉生物科技有限公司 | Preparation method of nano powder of non-metallic organic material |
| CN106619727A (en) * | 2016-11-28 | 2017-05-10 | 湖州珍露生物制品有限公司 | Pearl powder and preparation method thereof |
| CN109364009A (en) * | 2018-11-03 | 2019-02-22 | 江苏贝塔仕生物科技有限公司 | A kind of formula containing pearl powder beauty |
Also Published As
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| CN1268312C (en) | 2006-08-09 |
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