CN1582889A - Nano toothpaste additive - Google Patents
Nano toothpaste additive Download PDFInfo
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- CN1582889A CN1582889A CN 200410046144 CN200410046144A CN1582889A CN 1582889 A CN1582889 A CN 1582889A CN 200410046144 CN200410046144 CN 200410046144 CN 200410046144 A CN200410046144 A CN 200410046144A CN 1582889 A CN1582889 A CN 1582889A
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- toothpaste
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- tooth
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Abstract
A naon-class additive for toothpaste is Ca10(PO4)6(OH)2-xFx, where x=0-2. Its advantages are high biocompatibility, activity and bactericiding power, and no damage to tooth.
Description
Technical field
The present invention relates to a kind of novel nanoscale toothpaste additive, relate in particular to nano level Ca
10(PO
4)
6(OH)
2-xF
x, the toothpaste additive of 0≤x≤2 wherein.
Background technology
Usually contain grinding agent, wetting agent, foaming agent, thickening agent, antiseptic, flavour enhancer and water etc. in the toothpaste,, can add coloring agent, corrosion inhibiter, caries preventive agent, preventing dental plaque agent, anticalculus agent, antiinflammatory, deodorant etc. according to different purposes.Grinding agent wherein is used for removing tooth attachment and dental plaque, and particle diameter generally is in tens of microns.When the particle diameter of grinding agent was about 30 μ m, the oral cavity was the grittiness sensation, and particle diameter is big more, and is big more to the wearing and tearing of tooth, but cleaning capacity is strong more.Even grain diameter is month after month brushed teeth about 10 μ m throughout the year, tooth top layer enamel is worn away, after exposing cementum, the degree of wearing and tearing will be bigger, finally grinds a lot of groove mark on tooth, be easy to by bacteria attack, bad tooth, snaggletooth phenomenon occur, influence laboratory rodent chow and healthy.Calendar year 2001, " new function material " that the tribute that chemical publishing house publishes is long-living, Zhang Keli edits relates to the effect that the toothpaste that the interpolation hydroxyapatite is made in formulation of tooth-paste has caries prevention, reduces the tooth dirt at the 553rd page.Hydroxyapatite is a kind of specific adsorption agent simultaneously, can adsorb and remove the main bacteria streptococcus that causes dental caries, the outer property polysaccharide-glucosan of the born of the same parents that Streptococcus mutans etc. produce.Chinese invention patent 01114746.6 uses microcrystalline Cellulose as grinding agent, though alleviated the damage of grinding agent to tooth to a certain extent, can not fundamentally solve the problem of cleaning of teeth and repairing.
Summary of the invention
The purpose of this invention is to provide a kind of novel nanoscale toothpaste additive, nano level Ca especially is provided
10(PO
4)
6(OH)
2-xF
x, the toothpaste additive of 0≤x≤2 has wherein overcome the shortcoming of above-mentioned toothpaste additive, has the effect that can prevent and directly repair tooth wear.
The present invention is based on following principle: hydroxyapatite, Ca
10(PO
4)
6(OH)
2It is the inorganic constituents that constitutes vertebrates and human body hard tissue, as containing 65% hydroxyapatite in the composition of human body bone approximately, the surperficial hydroxyl apatite of people's tooth is more than 95%, nontoxic, being acknowledged as the star of medical bio pottery, is most important one big class in the biomaterial, and there are excellent biological compatibility and biological activity in soft tissue, sclerous tissues.Therefore, from biological viewpoint, hydroxyapatite is the substitution material that optimum is done organism sclerous tissues, can not have side effects to human body.Nano hydroxyl phosphorite crystal is easy to growth, and the composition on tooth enamel surface 95% is hydroxyapatite, therefore can play the function of direct reparation dental surface damage and decayed tooth.
OH in hydroxyapatite
-By F
-When partially or completely replacing, i.e. Ca
10(PO
4)
6(OH)
2-xF
x, 0≤x≤2 wherein can strengthen the enamel of dental surface, improve the tooth capacity antacid, and it also has the character of the function of direct reparation dental surface damage and decayed tooth simultaneously.
The additive of nanoscale, specific surface area is big, and is active high, be adsorbed on dental surface and fray easily, thus accelerated tooth to scarce nutrition absorption and replenish, stop up newborn crack in the tooth, play and effectively prevent dental caries, reduce the tooth dirt, reach the effect of cleaning teeth simultaneously.
A kind of novel nanoscale toothpaste additive provided by the invention can add in the toothpaste of various different efficacies, and described additive particle diameter is a nanoscale, and the particle diameter of described additive is preferably 10 ± 5～1000 ± 5nm;
Described additive is preferably Ca
10(PO
4)
6(OH)
2-xF
x, 0≤x≤2 wherein;
The content of described additive in toothpaste, the percentage composition meter is 0.001～10% by weight.
The present invention also provide a kind of preparation method of novel nanoscale toothpaste additive, comprise physical method, as mechanical crushing method, comprise ball milling, vibratory milling, vibromill, stirring mill, colloid mill and nanometer comminution by gas stream air-flow etc.; The evaporation-condensation method comprises the smoke particle crystallization process, the vacuum vapor deposition on the pasta that flows, plasma heating, LASER HEATING evaporation, electron beam heating evaporation method, arc discharge heating vaporization, high-frequency induction heating evaporation, solar furnace heating vaporization etc.; The ion sputtering method; Freeze-drying; Spark-discharge method; Explosive sintering method and chemical method as the gas-phase chemical reaction method, comprise gas-phase decomposition method, gas phase synthesis method, gas-solid reaction method; The sedimentation method comprise coprecipitation, hydrolytic precipitation method, hydrothermal synthesis method; Spray pyrolysis; The solvent evaporates decomposition method; Sol-gel process; The electrochemical synthesis method; The radiation chemistry synthetic method.
Because the present invention prepares the method for nanometer additive and the production technology of toothpaste is colleague's known technology that the technical staff was familiar with, so in an embodiment it is not described in detail.
Performances of Novel Nano-Porous meter level toothpaste additive of the present invention, its advantage is to comprise following aspect:
(1) additive has with tooth top layer enamel and similarly forms, and good biocompatibility is to tooth and the effect of oral cavity tissue not damaged;
(2) particle diameter of additive is a nanoscale, and nanometer size effect has strengthened the biological agent of additive, helps bringing into play its biological effect, active high, can accelerate the absorption of biological nutrition, be easy to adsorb dental surface or fray and grow and strengthen lethality antibacterial;
(3) nanometer additive becomes granule also to increase the lubricity of toothpaste, has reduced traditional toothpaste because the bulky grain damage that friction brings to dental bed;
(4) additive of nanoscale also has whitening effect;
(5) utilize the toothpaste of the additive preparation of nanoscale to meet national medical and health standard, can not have side effects to human body, the toothpaste of preparation is environmentally friendly, is a kind of ideal toothpaste additive.
The specific embodiment
Embodiment 1
With the 0.001g particle diameter is the Ca of 10 ± 5nm
10(PO
4) (OH)
2, calcium hydrogen phosphate 49g, sodium laurylsulfate 3g, carboxymethyl cellulose 1.2g, tetrasodium pyrophosphate 1g, glucide 0.3g, it is 100g that glycerol 25g, spice 1.3g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 2
With the 0.1g particle diameter is the Ca of 100 ± 5nm
10(PO
4) (OH)
2, calcium hydrogen phosphate 75g, hydrolysising protease 0.3g, surfactant 3g, the salt 0.5g of metal ion, it is 100g that binding agent 5g, neutral protease 0.05g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 3
With the 10g particle diameter is the Ca of 1000 ± 5nm
10(PO
4) (OH)
2, calcium hydrogen phosphate 50g, glucide 0.35g, glycerol 20g, spice 1.3g, sodium lauryl sulfate 2.5g, carboxymethyl cellulose 1g, it is 100g that Chinese herbal medicine desensitizer 0.5g, tetrasodium pyrophosphate 0.5g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 4
With the 0.001g particle diameter is the Ca of 10 ± 5nm
10(PO
4) (OH)
1.5F
0.5, sulfated lauryl alcohol 0.4g, sorbitol 0.25g, monoglyceride lauryl sulfate 0.75g, propylene glycol 1g, carboxymethyl cellulose 1.15g, glucide 0.12g, calcium pyrophosphate 39g, spice 0.85g, almasilate 0.4g, glycerol 18g, it is 100g that deionized water adds to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 5
With the 0.1g particle diameter is the Ca of 100 ± 5nm
10(PO
4) (OH)
1.5F
0.5, calcite 51.7g, glucide 0.3g, calcium hydrogen phosphate 0.3g, spice 1g, glycerol 17g, chlorophyll 0.04g, it is 100g that carboxymethyl cellulose 1.35g, sodium lauryl sulfate 2.5g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 6
With the 10g particle diameter is the Ca of 1000 ± 5nm
10(PO
4) (OH)
1.5F
0.5, glycerol 15g, natural whiting 54g, carboxymethyl cellulose 0.9g, sodium laurylsulfate 2.5g, hydroxyethyl-cellulose 0.7g, Chinese medicine extract 0.35g, glucide 0.35g, it is 100g that essence 1.1g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 7
With the 0.001g particle diameter is the Ca of 10 ± 5nm
10(PO
4) (OH) F, precipitated silica 18g, Macrogol 1540 2.0g, 70% sorbitol 65.67g, sodium lauryl sulfate 1.5g, carboxymethyl cellulose 0.7g, spice 1.25g, glucide 0.2g, chloroform 1.8g, the colouration agent 0.88g of 4% solution, it is 100g that deionized water adds to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 8
With the 0.1g particle diameter is the Ca of 100 ± 5nm
10(PO
4) (OH) F, aluminum sulfate 0.3g, sodium benzoate 0.5g, the color grain 0.5g of 0.3～1.5mm, glucide 0.2g, glycerol 22g, sodium laurylsulfate 1.5g, carboxymethyl cellulose 1g, calcium hydrogen phosphate two hydrate 46.75g, it is 100g that spice 0.9g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 9
With the 10g particle diameter is the Ca of 1000 ± 5nm
10(PO
4) (OH) F, aluminium hydroxide 50, spice 1.3g, carboxymethyl cellulose 1.2g, caries preventive agent 0.8, glycerol 20g, corrosion inhibiter 0.2g, it is 100g that surfactant 2.8g, glucide 0.35g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 10
With the 0.001g particle diameter is the Ca of 10 ± 5nm
10(PO
4) (OH)
0.5F
1.5, aluminium hydroxide 50g, glucide 0.3g, carboxymethyl cellulose 1.2g, spice 1.3g, glycerol 15g, corrosion inhibiter 0.4g, it is 100g that sodium lauryl sulfate 3g, depigmenting agent 0.2g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 11
With the 0.1g particle diameter is the Ca of 100 ± 5nm
10(PO
4) (OH)
0.5F
1.5, glycerol 25g, sorbitol 20g, calcium carbonate 45g, modified aluminium hydroxide 20g, sodium carboxymethyl cellulose 1.2g, dodecanol sodium sulfate 3g, saccharin sodium 0.1g, essence 1.2g, stabilizing agent 0.1g, copper gluconate 0.1g, it is 100g that deionized water adds to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 12
With the 10g particle diameter is the Ca of 1000 ± 5nm
10(PO
4) (OH)
0.5F
1.5, 50g calcium carbonate, sodium carboxymethyl cellulose 1g, glycerol 12g, essence 1g, lauryl alcohol sodium sulphate 2g, glucide 0.25g, waterglass or potassium nitrate 0.05g, it is 100g that calcium hydrogen phosphate 0.3g, vitamin c 0.2g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 13
With the 0.001g particle diameter is the Ca of 10 ± 5nm
10(PO
4) F
2, carrageenan 0.8g, glycerol 8g, saccharin sodium 0.35g, antiseptic 0.3g, pigment 0.1g, sodium lauryl sulfate 4g, it is 100g that essence 1g, silicon dioxide 4g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 14
With the 0.1g particle diameter is the Ca of 100 ± 5nm
10(PO
4) F
2, glycerol 15g, calcium hydrogen phosphate 40g, sodium carboxymethyl cellulose 1g, sodium lauryl sulfate 2g; saccharin sodium 0.3g, essence 1g, protective agent 0.1g, stabilizing agent 0.1g; it is 100g that epithelical cell growth factor 1g, silk peptide 0.5g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Embodiment 15
With the 10g particle diameter is the Ca of 1000 ± 5nm
10(PO
4) F
2, sodium carboxymethyl cellulose 1.2g, glycerol 15g, sorbitol 3.5g, sodium laurylsulfate 2.5g, glucide 0.3g, essence 1g, sodium dihydrogen phosphate 0.5g, it is 100g that calcium hydrogen phosphate 1g, SOD 0.1g, deionized water add to total amount, makes toothpaste according to the common technology of toothpaste production.
Claims (4)
1, a kind of novel nanoscale toothpaste additive is characterized in that, described additive particle diameter is a nanoscale.
According to the nanoscale toothpaste additive of claim 1, it is characterized in that 2, the particle diameter of described additive is 10 ± 5～1000 ± 5nm.
According to the nanoscale toothpaste additive of claim 1 or 2, it is characterized in that 3, described additive is Ca
10(PO
4)
6(OH)
2-xF
x, 0≤x≤2 wherein.
4, according to the nanoscale toothpaste additive of claim 1 or 2, it is characterized in that, the content of described additive in toothpaste, the percentage composition meter is 0.001～10% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046144 CN1582889A (en) | 2004-06-03 | 2004-06-03 | Nano toothpaste additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046144 CN1582889A (en) | 2004-06-03 | 2004-06-03 | Nano toothpaste additive |
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| Publication Number | Publication Date |
|---|---|
| CN1582889A true CN1582889A (en) | 2005-02-23 |
Family
ID=34601951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410046144 Pending CN1582889A (en) | 2004-06-03 | 2004-06-03 | Nano toothpaste additive |
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|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943437A (en) * | 2016-05-31 | 2016-09-21 | 安徽皖斛堂生物科技有限公司 | Dendrobium officinale toothpaste with antisepsis and anti-inflammation effects |
| CN106063776A (en) * | 2016-05-31 | 2016-11-02 | 安徽皖斛堂生物科技有限公司 | A kind of Herba Dendrobii toothpaste and preparation method thereof |
| RU2652193C1 (en) * | 2017-04-19 | 2018-04-25 | Федеральное государственное бюджетное учреждение науки Институт химии твердого тела Уральского отделения Российской академии наук | Method of preparing apatite suspension |
| CN109125178A (en) * | 2018-10-15 | 2019-01-04 | 安徽万春日化有限公司 | A kind of whitening toothpaste and preparation method thereof effectively removing creamy white spot |
-
2004
- 2004-06-03 CN CN 200410046144 patent/CN1582889A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943437A (en) * | 2016-05-31 | 2016-09-21 | 安徽皖斛堂生物科技有限公司 | Dendrobium officinale toothpaste with antisepsis and anti-inflammation effects |
| CN106063776A (en) * | 2016-05-31 | 2016-11-02 | 安徽皖斛堂生物科技有限公司 | A kind of Herba Dendrobii toothpaste and preparation method thereof |
| RU2652193C1 (en) * | 2017-04-19 | 2018-04-25 | Федеральное государственное бюджетное учреждение науки Институт химии твердого тела Уральского отделения Российской академии наук | Method of preparing apatite suspension |
| CN109125178A (en) * | 2018-10-15 | 2019-01-04 | 安徽万春日化有限公司 | A kind of whitening toothpaste and preparation method thereof effectively removing creamy white spot |
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