CN1579470A - Method for preparing traditional Chinese medicinal extract mixture - Google Patents
Method for preparing traditional Chinese medicinal extract mixture Download PDFInfo
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- CN1579470A CN1579470A CN 03154117 CN03154117A CN1579470A CN 1579470 A CN1579470 A CN 1579470A CN 03154117 CN03154117 CN 03154117 CN 03154117 A CN03154117 A CN 03154117A CN 1579470 A CN1579470 A CN 1579470A
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- radix
- extractum
- corii asini
- colla corii
- drying
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Abstract
The invention relates to a Chinese traditional medicine extractive compound, which is mainly made up of ginseng, dwarf lilyturf, magnolia vine fruit, astragalus root, angelica, arillus longan, cinnamon, ganoderma lucidum, spatholobus stem, Tuckahoe, hawkthorn, red-rooted salvia root, Chinese date kernel and accessories. The process is: crash, immersing blends and dries them. The extractive compound can be applied to produce capsule, tablet, sot capsule and drop pills and each kind of solid preparation.
Description
Technical field the present invention relates to a kind of Chinese medical concrete mixture, mainly be to be prepared into extractum by Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Arillus Longan, Cortex Cinnamomi, Ganoderma, Caulis Spatholobi, Poria, Fructus Crataegi, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae and adjuvant process, adding the Colla Corii Asini powder again can get.
The background technology confirmed fatigue is the syndrome of clinical manifestations such as a kind of extremely tired, low grade fever based on the outbreak of chronic or repeatability, throat pain, myalgia, arthralgia and neural mental symptom, symptom such as show as clinically that weak all over, headache and dizzy, eyes are dry and astringent, insomnia forgetfulness, shortness of breath and palpitation, hypomnesis, the constipation of getting angry, bradyphrenia, work efficiency decline, attention are difficult to concentrate.In the chinese tradition prescription, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis are the composition of ancient prescription SHENGMAI SAN, have the effect of supplementing QI for promoting the production of body fluid, astringing YIN to stop sweating; On this basis, add the Radix Astragali arteries and veins of making a living and go the side of Radix Glycyrrhizae, vigour that can the tonification human body; Add Radix Angelicae Sinensis again, can be Radix Ginseng a decotion of Chinese medicine to be taken cold and go the Radix Paeoniae Alba and get, but the QI invigorating lung heat clearing; Arillus Longan, Colla Corii Asini are the panacea of enriching blood, and with the deficiency of the gas of enriching blood, Colla Corii Asini can also play the effect of nourishing YIN and moistening the lung simultaneously; Semen Ziziphi Spinosae can tranquilizing by nourishing the heart, to go the disease of irritated insomnia; Ganoderma adds a small amount of Cortex Cinnamomi again for treating deficient key medicine in above-mentioned qi-invigorating, blood-nourishing medicinal, temperature fortune yang-energy is arranged, and inspires the effect of QI and blood growth.Adopt solid preparations such as granule that this technology makes, capsule that the confirmed fatigue symptom is had significant effect.
Summary of the invention the objective of the invention is to set up a kind of new Chinese medical concrete preparation process of mixture, can be used for treating the confirmed fatigue disease with its medicine for preparing gained.
Technical scheme of the present invention is: a kind of Chinese medical concrete mixture, form by Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Arillus Longan, Cortex Cinnamomi, Ganoderma, Caulis Spatholobi, Poria, Fructus Crataegi, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae and adjuvant, form extractum through extraction, mix with the Colla Corii Asini powder and get.
Its preparation method is:
(1) get Colla Corii Asini, sieve after crushed, standby.
(2) get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Arillus Longan, Cortex Cinnamomi, Ganoderma, Caulis Spatholobi, Poria, Fructus Crataegi, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae and put in the multi-function extractor, decoct with water, merge decoction liquor.Filter, concentrate put cold, standby.
(3) concentrated solution adds ethanol 4-6 and doubly measures, and stirs 10-20min, leaves standstill 24-72h, divides and gets supernatant, and residue adds 1 times of amount of ethanol, cleans merging supernatant, filtration 1-3 time; Reclaim ethanol to there not being the alcohol flavor, be condensed into extractum, standby.
The extractum that makes can be granulated routinely and marumerization prepares granule.
Extractum adds the Colla Corii Asini powder can carry out drying, makes the extractum mixture.
The extractum mixture can add adjuvant and be prepared tablet, capsule, soft capsule, drop pill etc.
Compared with prior art, the present invention has adopted new technology, and the material of its preparation can be used for the confirmed fatigue treatment of diseases.
The present invention is further illustrated below in conjunction with a plurality of specific embodiment for the specific embodiment:
1, get the prescription Chinese medicine, with different decocting times with decoct the temperature contrast, with leaching rate as index:
Decocting time (hour) the number of times leaching rate
1.0????????????????2????????????????39％
1.0????????????????3????????????????46％
2.0????????????????2????????????????59％
2.0????????????????3????????????????66％
3.0????????????????1????????????????56％
3.0????????????????2????????????????65％
2, the comparison of granulating efficiency:
With extractum and different auxiliary material with different ratios (adjuvant: extractum), method of granulating is granulated, and the result is as follows:
| Adjuvant | Ratio | Method of granulating | Effect |
| Sucrose | ????4∶1 | Wet granulation | Molding |
| Sucrose | ????3∶1 | One-step palletizing | Molding |
| Lactose | ????4∶1 | Wet granulation | Molding |
| Lactose | ????2.5∶1 | One-step palletizing | Molding |
| Dextrin | ????4∶1 | Wet granulation | Molding |
| Dextrin | ????2.5∶1 | One-step palletizing | Molding |
Thereby determine best proportioning, the preparation granule.
3, the preparation of extractum mixture:
(1) extractum is carried out spray drying, inlet temperature 180-220 ℃, leaving air temp 80-100 ℃, flow velocity 50Hz can get powder, adds the Colla Corii Asini powder again and mixes, and gets the extractum mixture.
(2) extractum is mixed with certain proportion with the Colla Corii Asini powder, put in the vacuum drying oven, carry out vacuum drying, temperature＜80 ℃ can get the extractum mixture.
4, the application of extractum mixture in the preparation tablet:
Get the extractum mixture, pulverize, prepare the tablet that all can be shaped by the following method:
| The adjuvant title | Tabletting method | Tablet |
| Starch, magnesium stearate are an amount of | Wet granulation | Molding |
| Starch, 70% ethanol, Pulvis Talci | Wet granulation | Molding |
| Microcrystalline Cellulose, hard ester acid | Direct compression | Molding |
5, the application of extractum mixture in the preparation capsule:
Get the extractum mixture, pulverize, prepare capsule by the following method, all can get:
| The adjuvant title | Granulate | Capsule 's content |
| Starch | Common granulation | Brown granule or powder |
| Micropowder silica gel | Do not granulate | Brown powder |
| Starch, micropowder silica gel | Dry granulation | Brown granule or powder |
6, the application of extractum mixture in the preparation soft capsule:
Get the extractum mixture, be ground into fine powder, add PEG and make suspension, the glue shell adopts gelatin, and the glue that glycerol and distilled water hot melt are made adopts pressing to be prepared soft capsule, and soft capsule can be shaped.
7, the application of extractum mixture in the preparation drop pill:
Get the extractum mixture, pulverize, with adjuvant with certain proportion (powder: adjuvant) mix, on DW5 type pilot scale drop pill machine, drip pill.
| The adjuvant title | Ratio | The drop pill effect |
| PEG4000 | ?1∶1 | Not molding |
| PEG4000 | ?1∶2 | Molding |
| PEG6000 | ?1∶1.5 | Basic forming |
| PEG6000 | ?1∶4 | Molding |
Claims (7)
1, a kind of Chinese medical concrete mixture forms extractum by Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Arillus Longan, Cortex Cinnamomi, Ganoderma, Caulis Spatholobi, Poria, Fructus Crataegi, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae and adjuvant through extraction, mixes with the Colla Corii Asini powder and gets.
2, the mixture described in the claim 1, its preparation method is:
(1) get Colla Corii Asini, sieve after crushed, standby;
(2) get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Angelicae Sinensis, Arillus Longan, Cortex Cinnamomi, Ganoderma, Caulis Spatholobi, Poria, Fructus Crataegi, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae and put in the multi-function extractor, decoct with water collecting decoction.Filter, concentrate put cold, standby;
(3) concentrated solution adds ethanol 4-6 and doubly measures, and stirs 10-20min, leaves standstill 24-72h, divides and gets supernatant, and residue adds ethanol, cleans merging supernatant, filtration 1-3 time; Reclaim ethanol to there not being the alcohol flavor, be condensed into extractum, standby;
(4) behind extractum and Colla Corii Asini powder drying and the mixed processes, promptly get the extractum mixture.
3, drying and the mixed processes described in claim 2 step (4) mixes with Colla Corii Asini after can be extract dry, or extractum with carry out drying again after Colla Corii Asini mixes.
4, the drying means described in claim 2 step (4) can be spray drying or boulton process.
5, the spray drying described in the claim 4, inlet temperature 180-220 ℃, leaving air temp 80-100 ℃, flow velocity 40-50Hz.
6, the vacuum drying described in the claim 4, temperature are 40-80 ℃.
7, the mixture described in the claim 1, available conventional formulation method prepares capsule, tablet, soft capsule, drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03154117 CN1579470A (en) | 2003-08-13 | 2003-08-13 | Method for preparing traditional Chinese medicinal extract mixture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03154117 CN1579470A (en) | 2003-08-13 | 2003-08-13 | Method for preparing traditional Chinese medicinal extract mixture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1579470A true CN1579470A (en) | 2005-02-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03154117 Pending CN1579470A (en) | 2003-08-13 | 2003-08-13 | Method for preparing traditional Chinese medicinal extract mixture |
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| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314345C (en) * | 2005-05-19 | 2007-05-09 | 重庆元亨药物研究有限公司 | Glossy ganoderma tea |
| CN105267637A (en) * | 2015-11-19 | 2016-01-27 | 哈尔滨圣吉药业股份有限公司 | Fatigue eliminating dispersible tablet and method for preparing same |
| CN106579442A (en) * | 2016-12-29 | 2017-04-26 | 广西南宁乐蕊生物科技有限责任公司 | Qi-replenishing and blood-enriching nutrient powder |
-
2003
- 2003-08-13 CN CN 03154117 patent/CN1579470A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314345C (en) * | 2005-05-19 | 2007-05-09 | 重庆元亨药物研究有限公司 | Glossy ganoderma tea |
| CN105267637A (en) * | 2015-11-19 | 2016-01-27 | 哈尔滨圣吉药业股份有限公司 | Fatigue eliminating dispersible tablet and method for preparing same |
| CN106579442A (en) * | 2016-12-29 | 2017-04-26 | 广西南宁乐蕊生物科技有限责任公司 | Qi-replenishing and blood-enriching nutrient powder |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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