CN1579321A - Airspace light-diving differential wavelength spectro meter for detecting artery blood content and detection method thereof - Google Patents
Airspace light-diving differential wavelength spectro meter for detecting artery blood content and detection method thereof Download PDFInfo
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- CN1579321A CN1579321A CN 200410019316 CN200410019316A CN1579321A CN 1579321 A CN1579321 A CN 1579321A CN 200410019316 CN200410019316 CN 200410019316 CN 200410019316 A CN200410019316 A CN 200410019316A CN 1579321 A CN1579321 A CN 1579321A
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Abstract
The invention discloses an airspace prismatic difference spectrum apparatus for artery blood ingredients detection, it is accurate, convenient, and it can measure ingredients of several organizations, it includes wideband lamp source with bandwidth of 600-1300nm, prismatic device and light path, light sensitive sensor, analog detecting channel, A/D converting model, CPU and its peripheral circuits; the prismatic device and the light path include prismatic device and light path devices matching to the prismatic device; the prismatic device uses gratings; the light path include wideband lamp source, the first condenser, measured human organization, the second condenser, grating and light sensitive element array; the light path output is photoelectric pulse wave signal; if arranges with light regulating baffle, thus the output of the light path is high frequency signal; the signal is converted into digital signal through A/D converting model and then processed with CPU, thus it can acquire the content of the primary ingredients in the artery blood. The invention also discloses the detection method of above mentioned spectrum apparatus.
Description
Technical field
The present invention relates to a kind of clinical medical inspection instrument and method, particularly a kind of arterial blood composition gauge and method.
Background technology
The noinvasive of morphological element detects, and for the diagnosis and the treatment of disease, its importance and immense value are undoubted.Not only, realize that the noinvasive of morphological element detects, great academic significance and value are also arranged in sensing, detection and processing in this.
U.S. scientist Jobsis reported first in 1977 observe the experimental result of the changes of contents of HbO2 Oxyhemoglobin, reduced hemoglobin and cytochrome c in the adult cat brain with near infrared light, disclosed near infrared light (700-1300nm) lower attenuation rate and with the feasibility of near infrared spectroscopy non-invasive monitoring tissue oxygenation concentration in biological tissue.In view of the extremely tempting application prospect of this new no wound measuring method, researcheres have been done a large amount of animals and experiment human body, have verified the clinical meaning with near infrared spectroscopy monitoring tissue oxygenation concentration from many aspects.Subsequently, the Delpy of Britain London university, the Jobsis of U.S. Duke university, the Tamura of Japan Hokkaido university, Yamamoto, and the Shiga of Japanese Omron company etc. by model, animal and human experimentation, puts forward the some kinds of calculation formula that changed the blood oxygen concentration variable quantity of calculating tissue by absorbance from the Lambert-Beer law.The portable tissue oxygenation meter of LASER Light Source has appearred replacing with common luminous tube LED in the exploitation of measuring device.Yet, because present method can only provide the variable quantity or the variation tendency of blood oxygen concentration, and lacks versatility, so all fail to enter clinical practice.
The eighties, D hne has proposed to use the method that near-infrared spectroscopy carries out the no wound measurement of human blood glucose concentration first.Since nearly 15 years, the companies such as Mitsui Metal Co., Ltd., Hitachi and Matsushita Electric Industries of the Medscience company of the Futrex company of the U.S., Bio-control company, New-mexico university, Iowa university, West Germany, Japan have all carried out unremitting research in this respect.Research method substantially can be divided into two classes, and the one, the research that utilizes the aqueous solution model of sugar to carry out is as the seminar of the Gray W.Small of Iowa university of the U.S.; Another kind of is directly to measure human body and to carry out correlation ratio right with result that blood drawing is measured, as the IMI company of the U.S. etc.Though the aqueous solution scale-model investigation of sugar makes important progress on the molecular absorption coefficient of accurately testing glucose, because of model is too simple, and the difference between human body is difficult to as a reference too greatly.Though and the direct effectiveness of verification method of human experimentation, but in fact and be not suitable for tissue with strong scattering characteristic as the Lambert-Beer law of concluding the quantitative approach basis, therefore the result who measures is difficult to explain, and does not have versatility and repeatability.From the angle of detection of biological histochemistry composition, tissue oxygenation concentration faces similar problem with blood sugar test.But, since a little less than the absorbance variable signal that the absorbance variable signal that the absorption of blood glucose causes causes than moisture many, at present, the research of the noinvasive optical detection technique of blood glucose concentrates on more and how to improve certainty of measurement to pick the variation that is changed the optical signal that causes by blood sugar content.So, although because potential tremendous economic interests, some famous in the world major companies in the past 20 in the period of dropped into a large amount of funds and developed, the noinvasive of blood glucose detects also has one section longer road to walk apart from practical application.Comparatively speaking, the economic worth that the noinvasive of other compositions of blood detects will be hanged down a bit, but difficulty bigger (because relative amount is low overlapping with absorption spectrum), external correlational study seldom mainly concentrates on the measurement of compositions such as blood lactic acid, hormone.And domesticly study) with regard to no one almost.Because individual difference and spectra overlapping, measuring condition (measuring position, ambient temperature and pressure), even dropped in the world the measurement of tissue oxygenation that huge manpower and financial resources studies and blood glucose still do not enter clinical practice (pulse blood oxygen is only arranged, be arterial blood oxygen generally enter clinically use and bring into play important role), the noinvasive of saying nothing of other compositions of blood detects.
Chinese patent publication number 1271562, open day on November 1st, 2000, title is to disclose a kind of self-service non-wound blood sugar measurer in the Chinese invention patent application documents of " self-service non-wound blood sugar measurer ", mainly the infrared light supply that is made of the infrared light transmitting tube leads to light path part, photodetection transducer, electric pathway part and display part and constitutes.Obviously, adopting the light source of single wavelength is the noinvasive tremulous pulse blood glucose content measurement that impossible be implemented in body.
Chinese patent publication number 1222063, open day on July 07th, 1999, name is called and discloses a kind of method and apparatus that is used to measure experimenter's blood sugar concentration in the Chinese invention patent application of " optical means and the device of determining blood sugar concentration ", its method comprises: a light pattern a) is provided, this pattern has bigger quantity of stimulus to first retina system than second retina system, the stimulation ratio that causes the first: the second is greater than 1, wherein said light pattern stimulates with the first: the second stimulation and than the subjective vision feature that changes and wherein said first retina system and second retina system sensitivity of the said light pattern blood sugar concentration with said experimenter is changed; B) make said experimenter observe the said subjective vision feature of said light pattern; With c) make said experimenter's blood sugar concentration relevant with said subjective vision feature.Obviously, this method is difficult to objective, measuring blood content quantitatively.A kind of Woundless blood sugar measuring apparatus is also disclosed in this patent application document.Realize that the measurement of noinvasive blood trouble sugar has two kinds of structures: (one) connects a probe at existing blood-glucose meter, oxygen electrode, glucase are arranged in the probe, and probe is connected with air pump, and probe is close to tester's finger, tissue fluid of oozing out on the finger and glucase effect, blood-glucose meter promptly records blood sugar concentration; (2) a controlled laser instrument is arranged, infrared beam is divided into two bundle light through grating, spectroscope, a branch of handle to point to reach chopper, a branch of with reference cell arrival chopper, chopper is delivered to infrared remote receiver with two-beam respectively, infrared remote receiver is delivered to microprocessor with signal, and computing is carried out in microprocessor binding data storehouse, and display shows measurement result.This application for a patent for invention is low by method complicated operation, the certainty of measurement of skin transudate, measurement composition kind is few, measure the cost height.
Obviously, adopt checkout gear complicated operation in the above-mentioned prior art, certainty of measurement is low, and it is few to measure the composition kind, measures the cost height.
Summary of the invention
In order to overcome above-mentioned deficiency of the prior art, it is accurate, easy to operate to the invention provides a kind of measurement, and can measure the method and the instrument of multiple morphological element simultaneously.The difference spectrum method that in the following description of the present invention, relates to, its notion is: in one group of photoelectricity pulse wave that records under different monochromatic light, the DC component that includes a large amount of individual variations and systematic error information is removed, and only retains the relevant AC compounent of blood with pulsation; Feature amplitude with described AC compounent is expressed the spectrum amplitude.The spatial domain optical spectroscopy that relates among the present invention, its notion is: by grating, carry out beam split on the spatial domain, can produce many group monochromatic light simultaneously.
In order to solve above-mentioned technical problem, the spatial domain beam split technical scheme that difference spectrograph adopts that the present invention is used for the detection of arterial blood composition is: described difference spectrograph comprises wideband light source, light-dividing device and light path thereof, light sensor, analog detection passage, A/D modular converter, CPU and peripheral circuit thereof; Described wideband light source adopts visible light and even the near infrared light of bandwidth at 600～1300nm; Described light-dividing device and light path thereof comprise light-splitting device and the light path devices that matches with it; Described light-splitting device adopts grating; Described light path comprises wideband light source, first condenser lens, tested person soma, second condenser lens, grating and photosensor array; What described light path was exported is the photoelectricity pulse wave signal; If between described wideband light source and described first condenser lens light modulation baffle plate is set, what then described light path was exported is high-frequency signal; Described photoelectricity pulse wave signal or high-frequency signal are handled by CPU after the A/D modular converter converts digital signal to, thereby obtain the content of main component in the arterial blood.
In difference spectrograph of the present invention, the effect of described light-sensitive device is to carry out opto-electronic conversion, and described light-sensitive device adopts one of following apparatus: photosensitive tube array, CCD device and arsenic gallium indium photosensor array.The effect of described analog detection passage is that the output signal with light-sensitive device converts the voltage signal with A/D modular converter coupling to, and described analog detection passage comprises photosensor array, I/V translation circuit, wave filter, phase sensitive detection, analog switch and A/D converter; The passband of described wave filter is between 0.1～30Hz.In addition, described analog detection passage comprises photosensor array, I/V translation circuit, wave filter, phase sensitive detection, frequency overlapped-resistable filter, analog switch and A/D converter; The passband mid frequency of described wave filter is at 20～2000Hz, and consistent to the modulating frequency of light with the light modulation baffle plate, and the passband bandwidth of described wave filter is at 20～200Hz.The signal of described photosensor array output switches to A/D converter and converts digital signal to by analog switch through I/V conversion, filtering and phase sensitive detection, and the switching frequency of described analog switch is consistent with the switching frequency of A/D converter.The effect of described A/D modular converter is to convert analog voltage signal to digital signal, and passes to described CPU; Described A/D modular converter comprises A/D converter spare and interface circuit thereof; Or described A/D converter is integrated in the cpu circuit.Described CPU and peripheral circuit thereof comprise cpu chip and minimal expansion system, interface circuit, output circuit and device, human computer conversation's module and control circuit; The effect of described CPU and peripheral circuit thereof is to receive the digital signal that described A/D modular converter transmits, and carries out post-processed and necessary output, simultaneously system is totally controlled the process with the human computer conversation.
The measuring method based on the difference spectrograph of spatial domain beam split that the present invention is used for that the arterial blood composition detects may further comprise the steps: first step connects comprise that wideband light source, light-dividing device and light path thereof, light sensor, analog detection passage, A/D modular converter, CPU and peripheral circuit thereof form utilize the spatial domain light-splitting method, determine the instrument of arterial blood composition by measuring pulse wave; Described wideband light source adopts visible light and even the near infrared light of bandwidth at 600～1300nm; Tested person soma is placed among the described light path, and the light path of formation comprises described wideband light source, first condenser lens, tested person soma, second condenser lens, grating and photosensor array; Second step, described CPU controls the emergent light of described wideband light source through first condenser lens, becomes a branch of directional light and incides tested person soma, and emergent light is sent into grating through second condenser lens; The signal of described grating output has one of following two kinds of situations: output comprises the pulse wave signal of spectral information; Or between described wideband light source and described first condenser lens, the light modulation baffle plate is set, then grating output is high-frequency signal; One group of monochromatic light in spatial distribution grating being exported with photosensor array carries out opto-electronic conversion; Third step, the real-time change of an output spectrum of each the photoelectric device response grating in the above-mentioned photosensor array, its output signal is through I/V conversion, filtering and phase sensitive detection, output is corresponding to this wavelength incident illumination, switch to A/D converter by analog switch then and respectively the output signal of different analog detection passages is carried out the A/D conversion, and send into CPU and carry out date processing; The 4th step, at first, CPU separates the data of corresponding different wave length signal, and the A/D transformation result that will come from same analog detection passage is carried out comprehensively, generates the pulse tracing ordered series of numbers; Then, adopt signal analysis method, extract the feature amplitude of every group of data and form difference spectrum as the spectrum amplitude corresponding to each lambda1-wavelength, its feature amplitude utilization is represented by the fundametal compoment of each difference pulse wave; Or represent that by peak-to-peak value of each group luminous point pulse wave described difference pulse wave is the AC compounent of photoelectricity pulse wave; Finally, by the spectrochemistry metering method, from difference spectrum, calculate the content of the main component in the arterial blood.
Compared with prior art, the beneficial effect of difference spectrum measuring method of the present invention and instrument is: because difference spectrograph of the present invention adopts difference detecting method, can remove the error that causes owing to individual variation, therefore, its measurement is accurate, easy to operate, and can measure multiple morphological element simultaneously.
Description of drawings
Fig. 1 is the structured flowchart of difference spectrograph of the present invention;
Fig. 2 is the grating detection light path sketch map when adopting no baffle plate in the difference spectrograph of the present invention;
Fig. 3 is the light path sketch map when adopting the light modulation baffle plate to cooperate with grating in the difference spectrograph of the present invention;
Fig. 4 is the electrical schematic diagram when adopting grating among the difference spectrograph embodiment one of the present invention;
Fig. 5 is the electrical schematic diagram when adopting grating among the difference spectrograph embodiment two of the present invention;
Fig. 6 is the workflow diagram when measuring with difference spectrograph of the present invention.
Be the explanation of main Reference numeral in the Figure of description of the present invention below.
1---wideband light source 2---light-dividing device and light path thereof
3---light sensor 4---analog detection passage
5---A/D modular converter 6---CPU and peripheral circuit thereof
7---first condenser lens 9---tested person soma
10---second condenser lens 12---grating
14---photosensor array 15---light modulation baffle plate
16---I/V translation circuit 17---analog switch
19---wave filter 21---A/D change-over circuit
25---phase-sensitive detection circuit 31---frequency overlapped-resistable filter
The specific embodiment
Below in conjunction with accompanying drawing difference spectrograph and the detection method based on the spatial domain beam split that the present invention is used for the detection of arterial blood composition is described in further details.
Extremely shown in Figure 5 as Fig. 1, the present invention is used for the difference spectrograph based on the spatial domain beam split that the arterial blood composition detects, and comprises wideband light source 1, light-dividing device and light path 2 thereof, light sensor 3, analog detection passage 4, A/D modular converter 5, CPU and peripheral circuit 6 thereof; Described wideband light source 1 adopts visible light and even the near infrared light of bandwidth at 600～1300nm; Described light-dividing device and light path 2 thereof comprise light-splitting device and the light path devices that matches with it; Described light-splitting device adopts grating 12; Described light path comprises wideband light source 1, first condenser lens 7, tested person soma 9, second condenser lens 10, grating 12 and photosensor array 14; What described light path was exported is the photoelectricity pulse wave signal; If between described wideband light source 1 and described first condenser lens 7 light modulation baffle plate 15 is set, what then described light path was exported is high-frequency signal; Described photoelectricity pulse wave signal or high-frequency signal are handled by CPU after A/D modular converter 5 converts digital signal to, thereby obtain the content of main component in the arterial blood.
In difference spectrograph of the present invention, the effect of described light-sensitive device 3 is to carry out opto-electronic conversion, and described light-sensitive device can adopt the photosensitive tube array, can also adopt CCD device or arsenic gallium indium photosensor array.
The effect of described analog detection passage 4 is that the output signal with light-sensitive device 3 converts the voltage signal with A/D modular converter 5 couplings to; Among the embodiment one as shown in Figure 4, described analog detection passage 4 comprises photosensor array 14, I/V translation circuit 16, wave filter 19, phase sensitive detection 25, analog switch 17 and A/D converter 21; The passband of described wave filter 19 is between 0.1～30Hz.Among the embodiment two as shown in Figure 5, described analog detection passage 4 comprises photosensor array 14, I/V translation circuit 16, wave filter 19, phase sensitive detection 25, frequency overlapped-resistable filter 31, analog switch 17 and A/D converter 21; The passband mid frequency of described wave filter 19 is at 20～2000Hz, and consistent with the modulating frequency of 15 pairs of light of light modulation baffle plate, and the passband bandwidth of described wave filter 19 is at 20～200Hz.
The signal of described photosensor array 14 outputs switches to A/D converter 21 and converts digital signal to by analog switch 17 through I/V conversion, filtering and phase sensitive detection, and the switching frequency of described analog switch 17 is consistent with the switching frequency of A/D converter 21.The effect of described A/D modular converter 5 is to convert analog voltage signal to digital signal, and passes to described CPU; Described A/D modular converter 5 comprises A/D converter spare and interface circuit thereof; Or described A/D converter is integrated in the cpu circuit.Described CPU and peripheral circuit 6 thereof comprise cpu chip and minimal expansion system, interface circuit, output circuit and device, human computer conversation's module and control circuit; The effect of described CPU and peripheral circuit 6 thereof is to receive the digital signal that described A/D modular converter 5 transmits, and carries out post-processed and necessary output, simultaneously system is totally controlled the process with the human computer conversation.
Workflow such as Fig. 1 and shown in Figure 6 that the present invention is used for that the arterial blood composition detects based on the difference spectrograph of spatial domain beam split, the optical signal that is sent by wideband light source 1 is through circuit part and the light path part conversion of being made up of light-dividing device and light path 2 thereof, light sensor 3, analog detection passage 4; That is the light 101 of the required wave-length coverage of sending by wideband light source 1; Incide first condenser lens 7, or be modulated into behind the high-frequency signal 102 through light modulation baffle plate 15; Incide first condenser lens 7 then, light is defocused through first condenser lens poly-7, incides tested person soma 9 as shown in the labelling 103; Its emergent light carries out beam split by grating 12 after second condenser lens 10 focuses on, be created in one group of monochromatic light 104 of spatial distribution.Receive the monochromatic light of grating 12 outputs by light sensor 3, and carry out opto-electronic conversion, shown in labelling 105; The output signal of described light sensor 3 realizes the signal conversion by corresponding analog detection passage 4, converts the signal of telecommunication that is suitable for A/D modular converter 5 to, shown in labelling 106; The described signal of telecommunication is sent into A/D modular converter 5, and convert thereof into digital signal, shown in labelling 107 by A/D modular converter 5; The dateout of described A/D modular converter 5 will be carried out post-processed by the data handling system that with CPU is core.That is, at first,, form pulse tracing ordered series of numbers 108 with the data separating of corresponding different wave length signal; Secondly, extract the amplitude of each difference photoelectricity pulse wave, form difference spectrum, its amplitude can be represented by the fundametal compoment of each difference pulse wave; Or represent 109 by peak-to-peak value of each group luminous point pulse wave; After obtaining difference spectrum, can pass through the spectrochemistry metering method, from difference spectrum, calculate the content 110 of the main component in the arterial blood.
The measuring method based on the difference spectrograph of spatial domain beam split that is used for that the arterial blood composition detects may further comprise the steps: first step connects comprise that wideband light source 1, light-dividing device and light path 2 thereof, light sensor 3, analog detection passage 4, A/D modular converter 5, CPU and peripheral circuit 6 thereof formed utilize the spatial domain light-splitting method, determine the instrument of arterial blood composition by measuring pulse wave; Described wideband light source 1 adopts visible light and even the near infrared light of bandwidth at 600～1300nm; Tested person soma 9 is placed among the described light path, and the light path of formation comprises described wideband light source 1, first condenser lens 7, tested person soma 9, second condenser lens 10, grating 12 and photosensor array 14; Second step, described CPU controls the emergent light of described wideband light source 1 through first condenser lens 7, becomes a branch of directional light and incides tested person soma 9, and emergent light is sent into grating 12 through second condenser lens 10; The signal of described grating 12 outputs has one of following two kinds of situations: output comprises the pulse wave signal of spectral information; Or between described wideband light source 1 and described first condenser lens 7, light modulation baffle plate 15 is set, then grating 12 outputs is high-frequency signal; One group of monochromatic light in spatial distribution grating 12 being exported with photosensor array 14 carries out opto-electronic conversion; Third step, the real-time change of an output spectrum of each the photoelectric device response grating in the above-mentioned photosensor array 14, its output signal is through I/V conversion, filtering and phase sensitive detection, output is corresponding to this wavelength incident illumination, switch to A/D converter 21 by analog switch 17 then and respectively the output signal of different analog detection passages 4 is carried out the A/D conversion, and send into CPU and carry out date processing; The 4th step, at first, CPU separates the data of corresponding different wave length signal, and the A/D transformation result that will come from same analog detection passage 4 is carried out comprehensively, generates the pulse tracing ordered series of numbers; Then, adopt signal analysis method, extract the feature amplitude of every group of data and form difference spectrum as the spectrum amplitude corresponding to each lambda1-wavelength, its feature amplitude utilization is represented by the fundametal compoment of each difference pulse wave; Or represent that by peak-to-peak value of each group photoelectricity pulse wave described difference pulse wave is the AC compounent of photoelectricity pulse wave; Finally, by the spectrochemistry metering method, from difference spectrum, calculate the content of the main component in the arterial blood.
Although invention has been described in conjunction with the accompanying drawings above; but the present invention is not limited to the above-mentioned specific embodiment; the above-mentioned specific embodiment only is schematic; rather than it is restrictive; those of ordinary skill in the art is under enlightenment of the present invention; not breaking away under the scope situation that aim of the present invention and claim protects, can also make a lot of distortion, these all belong within the protection of the present invention.
Claims (8)
1. one kind is used for the spatial domain beam split difference spectrograph that the arterial blood composition detects, and it is characterized in that: comprise wideband light source (1), light-dividing device and the light path (2) thereof, light sensor (3), analog detection passage (4), A/D modular converter (5), CPU and the peripheral circuit (6) thereof that are linked in sequence; Described wideband light source (1) adopts visible light and even the near infrared light of bandwidth at 600～1300nm; Described light-dividing device and light path thereof (2) comprise light-splitting device and the light path devices that matches with it; Described light-splitting device adopts grating (12); Described light path comprises wideband light source (1), first condenser lens (7), tested person soma (9), second condenser lens (10), grating (12) and photosensor array (14); What described light path was exported is the photoelectricity pulse wave signal; If between described wideband light source (1) and described first condenser lens (7) light modulation baffle plate (15) is set, what then described light path was exported is high-frequency signal; Described photoelectricity pulse wave signal or high-frequency signal carry out data characteristics by CPU and extract and post-processed after A/D modular converter (5) converts digital signal to, thereby obtain the content of main component in the arterial blood.
2. a kind of spatial domain beam split difference spectrograph that the arterial blood composition detects that is used for according to claim 1, it is characterized in that: the effect of described light sensor (3) is to carry out opto-electronic conversion, and described light sensor adopts one of following apparatus: photosensitive tube array, CCD device and arsenic gallium indium photosensor array.
3. a kind of spatial domain beam split difference spectrograph that the arterial blood composition detects that is used for according to claim 1, it is characterized in that: the effect of described analog detection passage (4) is that the output signal with light sensor (3) converts the voltage signal with A/D modular converter (5) coupling to, and described analog detection passage (4) comprises photosensor array (14), I/V translation circuit (16), wave filter (19), phase sensitive detection (25), analog switch (17) and A/D change-over circuit (21); The passband of described wave filter (19) is between 0.1～30Hz.
4. a kind of spatial domain beam split difference spectrograph that the arterial blood composition detects that is used for according to claim 1, it is characterized in that: the effect of described analog detection passage (4) is that the output signal with light sensor (3) converts the voltage signal with A/D modular converter (5) coupling to, and described analog detection passage (4) comprises photosensor array (14), I/V translation circuit (16), wave filter (19), phase sensitive detection (25), frequency overlapped-resistable filter (31), analog switch (17) and A/D change-over circuit (21); The passband mid frequency of described wave filter (19) is at 20～2000Hz, and consistent to the modulating frequency of light with light modulation baffle plate (15), and the passband bandwidth of described wave filter (19) is at 20～200Hz.
5. a kind of spatial domain beam split difference spectrograph that the arterial blood composition detects that is used for according to claim 1, it is characterized in that: the signal of described photosensor array (14) output is through I/V conversion, filtering and phase sensitive detection, switch to A/D change-over circuit (21) and convert digital signal to by analog switch (17), the switching frequency of described analog switch (17) is consistent with the switching frequency of A/D change-over circuit (21).
6. a kind of spatial domain beam split difference spectrograph that the arterial blood composition detects that is used for according to claim 1, it is characterized in that: the effect of described A/D modular converter (5) is to convert analog voltage signal to digital signal, and passes to described CPU; Described A/D modular converter (5) comprises A/D converter spare and interface circuit thereof; Or described A/D converter is integrated in the cpu circuit.
7. a kind of spatial domain beam split difference spectrograph that the arterial blood composition detects that is used for according to claim 1, it is characterized in that: described CPU and peripheral circuit thereof (6) comprise cpu chip and minimal expansion system, interface circuit, output circuit and device, human computer conversation's module and control circuit; The effect of described CPU and peripheral circuit thereof (6) is to receive the digital signal that described A/D modular converter (5) transmits, and carries out post-processed and necessary output, simultaneously system is totally controlled the process with the human computer conversation.
8. measuring method that is used for the spatial domain beam split difference spectrograph that the arterial blood composition detects is characterized in that described measuring method may further comprise the steps:
First step connects comprise that wideband light source (1), light-dividing device and light path (2) thereof, light sensor (3), analog detection passage (4), A/D modular converter (5), CPU and peripheral circuit (6) thereof formed utilize the spatial domain light-splitting method, determine the instrument of arterial blood composition by measuring pulse wave; Described wideband light source (1) adopts visible light and even the near infrared light of bandwidth at 600～1300nm; Tested person soma (9) is placed among the described light path, and the light path of formation comprises described wideband light source (1), first condenser lens (7), tested person soma (9), second condenser lens (10), grating (12) and photosensor array (14);
Second step, described CPU controls the emergent light of described wideband light source (1) through first condenser lens (7), becomes a branch of directional light and incides tested person soma (9), and emergent light is sent into grating (12) through second condenser lens (10); The signal of described grating (12) output has one of following two kinds of situations: output comprises the pulse wave signal of spectral information; Or between described wideband light source (1) and described first condenser lens (7), light modulation baffle plate (15) is set, then grating (12) output is high-frequency signal; One group of monochromatic light in spatial distribution grating (12) being exported with photosensor array (14) carries out opto-electronic conversion;
Third step, the real-time change of an output spectrum of each the photoelectric device response grating in the above-mentioned photosensor array (14), its output signal is through I/V conversion, filtering and phase sensitive detection, output is corresponding to this wavelength incident illumination, switch to A/D change-over circuit (21) by analog switch (17) then and respectively the output signal of different analog detection passages (4) is carried out the A/D conversion, and send into CPU and carry out date processing;
The 4th step, at first, CPU separates the data of corresponding different wave length signal, and the A/D transformation result that will come from same analog detection passage (4) is carried out comprehensively, generates the pulse tracing ordered series of numbers; Then, adopt signal analysis method, extract the feature amplitude of every group of data and form difference spectrum as spectrum amplitude corresponding to each lambda1-wavelength, its feature amplitude utilization represents that by the fundametal compoment of each difference pulse wave that Fourier transform is obtained described difference pulse wave is the AC compounent of photoelectricity pulse wave; Finally, by the spectrochemistry metering method, from difference spectrum, calculate the content of the main component in the arterial blood.
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| CN101933809A (en) * | 2010-08-31 | 2011-01-05 | 天津大学 | Multiband reflection spectrum noninvasive blood component measuring device and method |
| CN102512179A (en) * | 2011-12-27 | 2012-06-27 | 王培勇 | Non-destructive detector for human blood sugar |
| CN103315749A (en) * | 2013-05-30 | 2013-09-25 | 苏州光环科技有限公司 | Skin area positioning device, method and system applicable to blood glucose detection |
| CN109381197A (en) * | 2018-09-06 | 2019-02-26 | 北京大学 | Noninvasive dynamics monitoring device and its detection method based on articulations digitorum manus multispectral image |
| CN111700627A (en) * | 2020-07-20 | 2020-09-25 | 合肥铭源鸿医疗科技有限公司 | Noninvasive blood glucose detection system and blood glucose estimation method |
| CN114366090A (en) * | 2022-01-13 | 2022-04-19 | 湖南龙罡智能科技有限公司 | Blood component detection method integrating multiple measurement mechanisms |
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| CN1215814C (en) * | 2002-02-26 | 2005-08-24 | 南开大学 | Tester for saturation level of cerebral blood oxygen |
| CN1384348A (en) * | 2002-06-18 | 2002-12-11 | 天津大学 | Non-wound artirial blood component measuring instrument and method |
| CN1216567C (en) * | 2003-03-19 | 2005-08-31 | 北京大学 | High resolution detecting system for detecting finger tip pulse wave by photoelectric detecting frequency spectrum method |
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| CN101933809A (en) * | 2010-08-31 | 2011-01-05 | 天津大学 | Multiband reflection spectrum noninvasive blood component measuring device and method |
| CN101933809B (en) * | 2010-08-31 | 2013-06-12 | 天津大学 | Multiband reflection spectrum noninvasive blood component measuring device and method |
| CN102512179A (en) * | 2011-12-27 | 2012-06-27 | 王培勇 | Non-destructive detector for human blood sugar |
| CN103315749A (en) * | 2013-05-30 | 2013-09-25 | 苏州光环科技有限公司 | Skin area positioning device, method and system applicable to blood glucose detection |
| CN103315749B (en) * | 2013-05-30 | 2015-01-14 | 苏州光环科技有限公司 | Skin area positioning device, method and system applicable to blood glucose detection |
| CN109381197A (en) * | 2018-09-06 | 2019-02-26 | 北京大学 | Noninvasive dynamics monitoring device and its detection method based on articulations digitorum manus multispectral image |
| CN111700627A (en) * | 2020-07-20 | 2020-09-25 | 合肥铭源鸿医疗科技有限公司 | Noninvasive blood glucose detection system and blood glucose estimation method |
| CN114366090A (en) * | 2022-01-13 | 2022-04-19 | 湖南龙罡智能科技有限公司 | Blood component detection method integrating multiple measurement mechanisms |
| CN114366090B (en) * | 2022-01-13 | 2024-02-02 | 湖南龙罡智能科技有限公司 | Blood component verification method integrating multiple measurement mechanisms |
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