CN1569277A - Focus adjustable ultrasonic apparatus with low energy and its application for treating leukemia in vitro - Google Patents
Focus adjustable ultrasonic apparatus with low energy and its application for treating leukemia in vitro Download PDFInfo
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- CN1569277A CN1569277A CN 200410022443 CN200410022443A CN1569277A CN 1569277 A CN1569277 A CN 1569277A CN 200410022443 CN200410022443 CN 200410022443 CN 200410022443 A CN200410022443 A CN 200410022443A CN 1569277 A CN1569277 A CN 1569277A
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Abstract
A regulatable focusing low energy ultrasonic device and its application for the leukemia in vitro treatment are disclosed. The device mainly comprises a frame, a digit controlled motion platform, an ultrasonic source, an ultrasonic wave focusing controlling unit, an ultrasonic coupling unit, an ultrasonic positioning monitoring system and an ultrasonic intensity inspection and control system. It can be used for treating aged leukemia, aplastic leukemia, drug tolerance leukemia, obstinacy leukemia in vitro. It can be also applied in the prevention and treatment for recurrence after the marrow transplantation of leukemia.
Description
Technical field
The invention belongs to technical field of ultrasonic application, be specifically related to a kind of mental retardation ultrasound wave that utilizes focusing, make the leukaemia focusing mental retardation ultrasound wave leukemia external treatment system of apoptosis gradually from the external human bone marrow of directly acting on.
Background technology
Leukemia is the hematologic malignancies of serious threat child, person between twenty and fifty and part elderly population life, and sickness rate has the trend of increase in recent years.So far, treating leukemic main Therapeutic Method is constantly to use chemotherapy (abbreviation chemotherapy), induced apoptosis in leukemia cell lines; When having ready conditions, also use in the healthy marrow hemopoietic stem cells implant patient body marrow hemopoietic stem cells that to substitute pathological changes has taken place, can produce the leukaemia.Because above-mentioned Therapeutic Method has many defectives, so leukemic cure rate is still very low.
Ultrasound wave is the very high sound wave of a kind of frequency, can easily be converted to utilizable mechanical energy, has very strong object penetration, when it acts on certain material, can make generation sharp pounding between the material interior molecules and different physical changes takes place, utilize this specific character of ultrasound wave people can understand the state of different material, even can be transformed material.People are of long duration to hyperacoustic utilization, and application is constantly expanded.It is extremely successful that people utilize ultrasound wave to carry out the Clinics and Practices of disease, such as, diagnostic devices such as ultrasound physiotherapy equipment, the super machine of A, B ultrasonic machine; And ultrasonic thermotherapy and high intensity ultrasound treatment equipment etc., all obtained extraordinary effect, become requisite clinically diagnostic equipment.Patent application 98100283.8 discloses a kind of high-intensity focus supersonic tumor scanning therapy system.An outstanding feature of prior art equipment is exactly to be applied between destination organization and the non-destination organization comparatively clear and definite boundary is arranged, or ultrasound wave is had difference in the absorption, or direct requirement destroys and the pathological tissues that kills.Less demanding for the former to hyperacoustic focusing, then pursue focusing and high-energy for the latter.If from the angle of treatment, the latter's purpose is to utilize the high-energy concentration ultrasonic directly to kill pathological tissues.To high-energy ultrasound wave normal structure and pathological tissues is not optionally, can only depend on concentration ultrasonic and reach the purpose that does not injure normal structure.Therefore, this therapeutic equipment is only applicable to the treatment of solid tumor, and is inapplicable fully for the leukemic treatment that can't distinguish normal structure and pathological tissues.
The leukaemia is the dysplastic juvenile cell of a group, and it is not so good as normal cell to hyperacoustic tolerance.Discover, when leukaemia and normal cell mix, act on them simultaneously with the mental retardation ultrasound wave, if hyperacoustic intensity and FREQUENCY CONTROL are suitable, just can under the injury-free substantially prerequisite of normal cell (comprising hematopoietic stem cell), optionally make the leukaemia that apoptosis takes place.The inventor is in conjunction with ultrasound wave and leukaemia's characteristics, and the deficiencies in the prior art, has developed a kind of concentration ultrasonic leukemia external treatment system.Experiment showed, that technical scheme is feasible, effect is good.
The innovation and creation content
1, the technical problem that will solve
The object of the present invention is to provide a kind of reasonable in design, with low cost, high focusing, frequency, intensity (energy) regulatable focusing mental retardation ultrasonic unit.
Another object of the present invention is regulatable focusing mental retardation ultrasonic unit is applied to the external treatment leukemia.
2, technical scheme
First purpose of the present invention is achieved in that and comprises that mainly frame, numerical control motion platform, supersonic source, ultrasound wave focus control device, ultrasonic coupler device, ultrasonic locating monitoring system, ultrasonic intensity detect and control system is formed.Frame is horizontal portal frame structure, is provided with base, and an end device of base has column, column upper end and lateral frame Joint; Lateral frame middle part is provided with motor fixing frame, and motor wherein is installed, and motor is by the gear drive swivel mount, and the swivel mount bottom is provided with arc-shaped guide rail, arc-shaped guide rail respectively with supersonic source holder, ultrasonic detector holder movingly; The both sides that are symmetrical in fixed mount on the lateral frame are installed x-ray generator respectively, and intersection is corresponding to the X-ray accepter that is provided with respectively on the base, and the cross point of two bundle X-rays and ultrasonic transmitter and accepter acoustic reflection point are in " O " point together; Stand arrangement is on digital control platform, and to realize the lifting and the translation of frame, the top of supersonic generator is provided with the ultrasonic coupler device; Numerical control therapeutic bed and frame cross-over configuration, the bedstead of numerical control therapeutic bed is provided with mobile controlling organization, and step motor drive gear, bolt and nut device drive bed board and accurately move.
Another object of the present invention is achieved in that being applied to regulatable focusing mental retardation ultrasonic unit external treatment leukemia comprises the following steps:
(1) before the treatment, at first extract the human bone marrow and carry out leukaemia's detection, apoptosis takes place and injury-free critical ultrasonic energy, frequency and the exposure time (irradiation intensity) of normal cell in the definite leukaemia of experiment.
(2) determine the skeleton that the needs ultrasonic irradiation is treated according to patient's concrete condition, carry out X-ray control location, will be input in the computer by irradiation skeleton space position parameter; Measure the reflectance ultrasound intensity of wave, compare with critical irradiation intensity value again, the control intensity when determining treatment irradiation.
(3) according to the shape of different skeletons and the space position parameter of determining by X-ray, control numerical control motion platform and numerical control therapeutic bed, work " O " point of device is positioned according to the determined space position parameter of step 2, thereby this section skeleton is carried out multibreak suitable shape ultrasonic irradiation, stop irradiation after reaching definite control dosage, finish the seance process.
3, beneficial effect
Because the present invention has adopted ultrasound wave focusing system, ultrasonic locating monitoring, reflection supersonic wave to detect control and import technology such as dosage and numerical control motion platform, make and not only can accurately control ultrasonic therapy dosage, and can carry out scanning radiation to any position of human body exactly, this device is applied to the external treatment leukemia.
Description of drawings
The present invention is described further below in conjunction with accompanying drawing and embodiment, but never in any form the present invention is limited.
Fig. 1 looks sketch map for rack construction master of the present invention;
Fig. 2 is a numerical control therapeutic bed structural representation of the present invention;
Fig. 3 is a numerical control motion platform sketch map of the present invention;
Fig. 4 is an overall structure schematic perspective view of the present invention.
Fig. 5 is a computer control workflow diagram of the present invention.
The specific embodiment
As shown in Figure 1-Figure 3, the present invention comprises that mainly frame, numerical control motion platform, supersonic source, ultrasound wave focus control device, ultrasonic coupler device, ultrasonic locating monitoring system, ultrasonic intensity detect and control system is formed.Frame is horizontal portal frame structure, is provided with base 30, and an end device of base 30 has column 29, column 29 upper ends and lateral frame 28 Joints; Lateral frame 28 middle parts are provided with motor fixing frame 12, motor 11 wherein is installed, motor 11 drives swivel mounts 8 by gear 10,9, and swivel mount 8 bottoms are provided with arc-shaped guide rail 4, arc-shaped guide rail 4 respectively with supersonic source holder 2, ultrasonic detector holder 6 movingly; The both sides that are symmetrical in fixed mount 12 on the lateral frame are installed x-ray generator 13,14 respectively, intersection is corresponding to the X-ray accepter 15,16 that is provided with respectively on the base 30, the cross point of two bundle X-rays and ultrasonic transmitter 1 and accepter 5 acoustic reflections point are in " O " point together, and the top of supersonic generator 1 is provided with ultrasonic coupler device 17.
The gear 3 of supersonic source holder 2, the gear 7 of ultrasonic detector holder 6 are meshed with tooth bar on the arc track 4 respectively, reach the purpose of control displacement.
Fig. 2 shows the structure of numerical control therapeutic bed, and device bedstead 19 is provided with mobile controlling organization on its pedestal 18, and motor 20 driven wheels 22, bolt and nut device 21 drive bed board 23 and accurately move.
Fig. 3 shows the structure of digital control platform, and device has translation plates 26 on its pedestal 27, an end device fixed support plate 25 on it, device lifter plate 24 on the fixed support plate 25.Lifter plate 24 Joints on framework pillar 29 and the digital control platform are to realize the lifting and the translation of frame.
Fig. 4 shows overall structure of the present invention.Numerical control therapeutic bed and the frame cross-over configuration of device on digital control platform are to realize moving relative to three-dimensional position of therapeutic bed and ultrasound wave focus point " O ".
As a kind of application of regulatable focusing mental retardation ultrasonic unit, i.e. external treatment leukemia.Fig. 5 shows the leukemic computer control workflow diagram of device external treatment of using the present invention.
Supersonic source is made up of excess sound pressure electric transducer and control power supply, and the superaudio telegraph that piezoelectric transducer earthquake circuit produces number effect produces ultrasound wave down, and the frequency and the amplitude that change the signal of telecommunication can change frequency of ultrasonic and intensity (power).Electric transducer combination array (coupling probe) is made concave spherical surface or recessed cylinder shape to be helped ultrasound wave and is focused into point-like or wire.
When the ultrasound wave focus point scanned a certain skeleton cross section place, computer can demonstrate corresponding skeleton image immediately, was convenient to determine hyperacoustic focus active position.
Ultrasound wave is when acting on human body, be subjected to soft tissue, bone surface shape, skeleton density and the different influence of ultrasound wave incident angle, can produce reflection and refraction on the different tissues surface, and even defocus (expansion in burnt territory), some ultrasonic having entered in the bone only, the total ultrasonic energy that imports in the human body bone can be extrapolated by the hyperacoustic intensity of detection of reflected, ultrasound wave can be controlled exactly to partial effect dosage by computer control.
Operation principle of the present invention and work process:
Ultrasound wave is focused on and adjusts under lower energy and the characteristic frequency state, utilize leukaemia and normal plasma cell to mental retardation and the hyperacoustic tolerance difference of characteristic frequency, pass through exposure time again, reach under the prerequisite that normal plasma cell preserves from, make leukaemia's purpose of apoptosis gradually.
Characteristics of the present invention:
1, apparatus of the present invention are simple in structure, and control is accurate, and hyperacoustic frequency, intensity can be accurate Regulation and control, working stability is reliable.
2, the present invention can be used for external treatment leukaemia. Use the external treatment of low-yield concentration ultrasonic System induces in the marrow or/and the interior apoptosis of leukemia of superficial vein. Can reach that to keep the patient white The purpose of the sick long-term remission of blood, can not adopt or the present leukemia treating of less employing in conventional institute carry out Consolidate embolic chemotherapy, may reduce or replace to a certain extent and consolidate chemotherapy, fall to greatest extent again Low even avoided the side effect of chemotherapy, improve leukaemic's life quality.
3, can be applicable to treat senile leukaemia, aplastic leukemia, drug resistance leukaemia, Refractory Leukemia. These leukemic common features are to tolerate regular chemotherapy drug therapy or just The effect of rule chemotherapy is very poor, and the present invention can induce gradually apoptosis of leukaemia, and normal cell decreases Hinder littler.
4, can be applicable to treatment and the prevention of recurring behind the leukemic patients after bone marrow transplantation.
5, the present invention is the important treatment means after chemotherapy, bone-marrow transplantation treatment leukaemia, can become The third primary treatment means for leukemia treating.
Claims (6)
1, a kind of regulatable focusing mental retardation ultrasonic unit, mainly comprise frame, numerical control five dimension motion platforms, supersonic source, the ultrasound wave focus control device, the ultrasonic coupler device, the ultrasonic locating monitoring system, ultrasonic intensity detects and control system is formed, frame is horizontal portal frame structure, be provided with base (30), one end device of base (30) has column (29), column (29) upper end and lateral frame (28) Joint, it is characterized in that: lateral frame (28) middle part is provided with motor fixing frame (12), motor (11) wherein is installed, motor (11) is by gear (10,9) drive swivel mount (8), swivel mount (8) bottom is provided with arc-shaped guide rail (4), arc-shaped guide rail (4) respectively with supersonic source holder (2), ultrasonic detector holder (6) movingly; The both sides that are symmetrical in fixed mount (12) on the lateral frame are installed x-ray generator (13,14) respectively, intersection is corresponding to the X-ray accepter (15,16) that is provided with respectively on the base (30), and the cross point of two bundle X-rays and ultrasonic transmitter (1) and accepter (5) acoustic reflection point are in " O " point together; (27) lifter plate (24) Joint on framework pillar (29) and the digital control platform; Numerical control therapeutic bed (18) and the frame cross-over configuration of device on digital control platform (27) are to realize moving relative to three-dimensional position of therapeutic bed and ultrasound wave focus point " O ".
2, regulatable focusing mental retardation ultrasonic unit as claimed in claim 1, it is characterized in that: the top of supersonic generator (1) is provided with ultrasonic coupler device (17).
3, regulatable focusing mental retardation ultrasonic unit as claimed in claim 1 is characterized in that: the gear (3) of supersonic source holder (2), the gear (7) of ultrasonic detector holder (6) are meshed with tooth bar on the arc track (4) respectively.
4, regulatable focusing mental retardation ultrasonic unit as claimed in claim 1, it is characterized in that: install bedstead (19) on described numerical control therapeutic bed (18) pedestal and be provided with mobile controlling organization, motor (20) driven wheel (22), bolt and nut device (21) drive bed board (23) and accurately move.
5, regulatable focusing mental retardation ultrasonic unit as claimed in claim 1, it is characterized in that: device has translation plates (26) on the pedestal of described digital control platform (27), an end device fixed support plate (25) on it, fixed support plate (25) is gone up device lifter plate (24).
6, a kind of device as claimed in claim 1 is characterized in that comprising the following steps: in the leukemic application of external treatment
(1) before the treatment, at first extract the human bone marrow and carry out leukaemia's detection, apoptosis takes place and injury-free critical ultrasonic energy, frequency and the exposure time (irradiation intensity) of normal cell in the definite leukaemia of experiment.
(2) need to determine the skeleton of ultrasonic irradiation treatment, carry out X-ray control location, will be input in the computer by irradiation skeleton space position parameter; Measure the reflectance ultrasound intensity of wave, compare with critical irradiation intensity value again, the control intensity when determining treatment irradiation.
(3) according to the shape of different skeletons and the space position parameter of determining by X-ray, control numerical control motion platform and numerical control therapeutic bed, work " O " point of device is positioned according to the determined space position parameter of step 2, thereby this section skeleton is carried out multibreak suitable shape ultrasonic irradiation, stop irradiation after reaching definite control dosage, finish the seance process.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100224437A CN100408128C (en) | 2004-04-29 | 2004-04-29 | Focus adjustable ultrasonic apparatus with low energy and its application for treating leukemia in vitro |
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| CNB2004100224437A CN100408128C (en) | 2004-04-29 | 2004-04-29 | Focus adjustable ultrasonic apparatus with low energy and its application for treating leukemia in vitro |
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| CN1569277A true CN1569277A (en) | 2005-01-26 |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100460033C (en) * | 2005-02-23 | 2009-02-11 | 深圳市普罗惠仁医学科技有限公司 | Motion locating system for target focusing physical treating equipment |
| CN104190006A (en) * | 2014-09-11 | 2014-12-10 | 孙非 | Transduction device for high-intensity focused ultrasound |
| CN107233672A (en) * | 2017-07-11 | 2017-10-10 | 修海波 | A kind of ear-nose-throat department sonicator |
| CN108837338A (en) * | 2018-05-03 | 2018-11-20 | 王磊 | A kind of Neurology brain sonicator |
| CN109432586A (en) * | 2018-11-26 | 2019-03-08 | 南京航空航天大学 | A kind of targeted therapy ultrasound drug delivery system and working method applied to superficial tumor |
| CN110151179A (en) * | 2018-03-19 | 2019-08-23 | 鲁强 | A kind of nuclear magnetic resonance multifunctional examining device |
| CN110689792A (en) * | 2019-11-19 | 2020-01-14 | 南方医科大学深圳医院 | Ultrasonic examination virtual diagnosis training system and method |
| CN111632285A (en) * | 2020-05-28 | 2020-09-08 | 杜颖 | Joint gout treatment device |
| CN112472135A (en) * | 2020-11-27 | 2021-03-12 | 广州通泽医疗科技有限公司 | Dot-matrix focused ultrasonic energy output device |
| CN114682471A (en) * | 2022-03-08 | 2022-07-01 | 吉林大学 | Ultrasonic control device and detection system |
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| US5036855A (en) * | 1988-03-02 | 1991-08-06 | Laboratory Equipment, Corp. | Localization and therapy system for treatment of spatially oriented focal disease |
| CN1073453C (en) * | 1996-12-27 | 2001-10-24 | 中国科学院声学研究所 | In vitro supersonic therapeutical instrument for medical purpose |
| CN1185983A (en) * | 1997-09-27 | 1998-07-01 | 深圳奥沃国际科技发展有限公司 | Supersonic therapeutic instrument for cerebral thrombus |
| AU763938B2 (en) * | 1998-09-11 | 2003-08-07 | Gr Intellectual Reserve, Llc | Methods for using resonant acoustic energy to detect or effect structures |
| CN1260217A (en) * | 1999-01-12 | 2000-07-19 | 武汉天使科技发展有限公司 | Supersonic therapeutic device for tumor |
| CN1132639C (en) * | 2000-08-31 | 2003-12-31 | 上海交通大学 | Driving device for focus ultrasonic transmitter |
| CN1410031A (en) * | 2002-11-21 | 2003-04-16 | 上海交通大学 | Stereo positioning system in high strength focusing ultrasonic operation |
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| CN100460033C (en) * | 2005-02-23 | 2009-02-11 | 深圳市普罗惠仁医学科技有限公司 | Motion locating system for target focusing physical treating equipment |
| CN104190006B (en) * | 2014-09-11 | 2019-08-20 | 杭州德诺睿华医疗科技有限公司 | A kind of transducing head for high intensity focused ultrasound |
| CN104190006A (en) * | 2014-09-11 | 2014-12-10 | 孙非 | Transduction device for high-intensity focused ultrasound |
| CN107233672A (en) * | 2017-07-11 | 2017-10-10 | 修海波 | A kind of ear-nose-throat department sonicator |
| CN107233672B (en) * | 2017-07-11 | 2019-05-17 | 修海波 | A kind of ear-nose-throat department sonicator |
| CN110151179A (en) * | 2018-03-19 | 2019-08-23 | 鲁强 | A kind of nuclear magnetic resonance multifunctional examining device |
| CN108837338A (en) * | 2018-05-03 | 2018-11-20 | 王磊 | A kind of Neurology brain sonicator |
| CN109432586A (en) * | 2018-11-26 | 2019-03-08 | 南京航空航天大学 | A kind of targeted therapy ultrasound drug delivery system and working method applied to superficial tumor |
| CN109432586B (en) * | 2018-11-26 | 2021-02-19 | 南京航空航天大学 | Ultrasonic drug delivery system for targeted therapy of superficial tumors and working method |
| CN110689792A (en) * | 2019-11-19 | 2020-01-14 | 南方医科大学深圳医院 | Ultrasonic examination virtual diagnosis training system and method |
| CN111632285A (en) * | 2020-05-28 | 2020-09-08 | 杜颖 | Joint gout treatment device |
| CN112472135A (en) * | 2020-11-27 | 2021-03-12 | 广州通泽医疗科技有限公司 | Dot-matrix focused ultrasonic energy output device |
| CN114682471A (en) * | 2022-03-08 | 2022-07-01 | 吉林大学 | Ultrasonic control device and detection system |
| CN114682471B (en) * | 2022-03-08 | 2022-11-29 | 吉林大学 | Ultrasonic control device and detection system |
| WO2023169036A1 (en) * | 2022-03-08 | 2023-09-14 | 吉林大学 | Ultrasonic control device and ultrasonic control testing system |
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