CN1185982A - In vitro supersonic therapeutical instrument for medical purpose - Google Patents
In vitro supersonic therapeutical instrument for medical purpose Download PDFInfo
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- CN1185982A CN1185982A CN96114078A CN96114078A CN1185982A CN 1185982 A CN1185982 A CN 1185982A CN 96114078 A CN96114078 A CN 96114078A CN 96114078 A CN96114078 A CN 96114078A CN 1185982 A CN1185982 A CN 1185982A
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Abstract
An ultrasonic therapeutic apparatus using ultrasonic technique is composed of tumor locating device using ultrasonography B, ultrasonic generator, emitter, high-intensity ultrasonic focusing transducer, ultrasonic medium and 3-D automatic search device. It features the use of heat effect in human tissue to treat tumor or affected phyma and mechanical effect in human tissue to break off internal calculi. Its advantages include simple operation, reliable performance, distinct curative effect and no by-effect.
Description
The present invention relates to a kind of ultrasonic therapeutic system in the applied acoustics, for these years, people carry out indomitable effort for the treatment cancer always.One of way of the tumor thermotherapy a kind of effective treatment tumor that to be people go out by Science Explorations and practice summary, the ultrasound wave tumor thermotherapy is the major measure of tumor thermotherapy, ultrasound wave is a kind of fluctuation of transmitting energy, in different medium, ultrasound wave can transfer the energy to certain distance.Therefore, utilize the transmission of ultrasonic energy, concentration of energy on intravital focus, is produced enough heat, suppress the growth of tumor cell and the further deterioration of focus, thereby reach the purpose of treatment tumor and elimination focus.The Li Ding of Hunan tumour hospital nine, recklessly examine oneself and point out in " tumor thermotherapy " book of doctor's compiling: ultrasonic heating can reach deep layer, and adding focusing with several super acoustic emanations can heat in certain zone more satisfactorily in uniform temperature.In recent ten years, the proposition of high-intensity focusing ultrasonic wave technology and realization have effectively promoted the development of supersonic tumor thermotherapy, become the key areas that ultrasonic technique is used aspect biomedical engineering.
Nineteen eighty-three, the Bake Beck of Hai Yaqi (Hayashi) and 1940 successively reports: since the phenomenons such as " ultrasound wave can make the animal tumor growth delay; and idol can make tumor regression; increase in temperature is the reason of tumor regression ", biologist, physicist and engineering expert have carried out this working in large quantities, from ultrasonic propagation characteristic on tissue to human body cell, each organs and tissues has carried out extensive studies to aspects such as hyperacoustic reactions, China takes to the research of this respect at the seventies, obtained a lot of important achievements, Shanghai Communications University is that this respect is carried out the work than one of unit early.
However, people fail to propose a whole set of and are used for clinical practicality therapy apparatus, so that this technology is applied even more extensively and puts into practice type research further.
The objective of the invention is to propose a kind of mainly by B ultrasonic positioner, ultrasound wave generation, discharger, high-strength ultrasonic focused transducer and sound wave transmission medium body and the medical external supersonic therapy apparatus formed from the motion tracking three-dimensional motion device, it need not performed the operation in therapeutic process, no pain, and simple to operate, safely, have no side effect, thereby solved the existing in prior technology problem.
Ultransonic biological effect is paid close attention to by people already, and the character that ultransonic biological effect is used for the sound intensity, frequency and biological tissue itself has much relations.By the mechanism of action, it can be divided into: heat effect, mechanical effect, acoustic streaming effect and cavitation effect.And the present invention utilizes the absorption characteristic of biological tissue to energy, and the ultrasonic energy of injecting tissue will become heat energy, and its temperature is raise, and promptly biological heating effect to reach the necessary temperature of tumor, is generally 42 ℃ to 44 ℃.The present invention adopts the way of same phase focused sound waves, concentrates on focus with making energy high strength, acts on diseased region, but not the diseased region damage is less, reaches ideal thermotherapy effect.For this reason, scheme of the present invention mainly is: it is formed by B ultrasonic positioner, ultrasound wave generation, discharger, high-strength ultrasonic focused transducer and sound wave transmission medium body with from the motion tracking three-dimensional motion device.Said B ultrasonic positioner is to adopt existing commercially available prod; Said ultrasound wave takes place, discharger is to include: signal source, power amplification circuit and control circuit and signal source is to guarantee that the same phase ultrasonic signal takes place, its frequency is between 1MHz to 2MHz.Control circuit have control location, regularly, the effect of energy adjustment.And directly by computer control.Power amplifier can produce power emission periodically, and the emission cycle can be set arbitrarily by computer, adopts two cover high frequency power amplifier, radiation patterns continuously; Said high-strength focused transducer is by 200 20 * 20mm
2The transducing unit form, the transducing unit adopts parallel connection or serial connection mode to be arranged in the surface of Internal Spherical Surface in an orderly manner, forms the transmitter unit array of Internal Spherical Surface; Also can adopt the transducing unit is divided into some groups, each group unit is parallel on the strip balance weight body of Internal Spherical Surface, more some balance weight body evenly is fixed on the spherical shape that forms on the circular support, and the centre of sphere is the focus of transducer arrays; Said ultrasonic propagation dielectric then stays water to be formed by entrant sound capsule and steaming; Said three-dimensional motion device, it is a kind of actuating unit by computer-controlled servo motor.It can be automatically along X, Y, and three directions of Z move.
The invention has the advantages that: its therapeutic effect is obvious, need operation, external treatment, no pain; Treatment time is short; Safety, convenient has no side effect; The present invention is simple in structure, easy to operate, dependable performance.The present invention is owing to a series of new and high technologies such as high-strength focused transducer, B ultrasonic location, micro-processor controlled automatic scams, make the present invention have high use value.
Fig. 1 is a system structure sketch map of the present invention.
Fig. 2 is a high-intensity focusing ultrasonic wave transducer sketch map of the present invention.
Fig. 3 is signal source circuit figure of the present invention.
Fig. 4 is control signal source circuit figure of the present invention.
Fig. 5 is power amplification circuit figure of the present invention.
Fig. 6 is the theory diagram of system of the present invention.
Fig. 7 is high-frequency high-power decoupling circuit figure of the present invention.
Further specify preferred embodiment of the present invention in conjunction with above-mentioned each accompanying drawing now, the present invention is mainly by B ultrasonic positioner 1, ultrasound wave generation, discharger 9, high-strength ultrasonic focused transducer 3, sound wave transmission medium body 11, and form from motion tracking three-dimensional motion device 8, as shown in Figure 1.Wherein:
1.B overdetermination position device 1, it be diagnosis in-vivo tumour and focus effective means, Ultrasonic-B probe is placed on the Ultrasonic-B probe support 17, high-strength focused energy transducer focus 5 is locked in the scanning plane of B ultrasonic relatively, the focus of the just mobile transducer 3 of process of B ultrasonic search in-vivo tumour, focus is implemented on localized tumor of B ultrasonic or focus, and this has just finished location process.
2. ultrasound wave generation, discharger 9: it is made up of parts such as signal source, control circuit, pre-amplification circuit, high frequency power amplifier and power governors.To shown in Figure 7, its all parameters and function are by computer settings and control as Fig. 3.
A, signal source as shown in Figure 3, it is the frequency divider by crystal oscillator and arbitrary proportion, shaping output is formed.Have frequency stabilization, can be in harmonious proportion front and back along steep pulse signal.
B, control circuit connect mouthful circuit as Fig. 4, this part shown in Figure 5 and directly are connected with computer.To controls such as emission cycle, frequency, power, timings.
C, preposition amplification and power amplifier, as shown in Figure 5, preamplifier adopts single tube amplification, emitter follower output, power field effect pipe during its driving output is adopted, the mode of closing with the transformator Rhizoma Nelumbinis is connected with power amplifier.U wherein
5To U
10Be to adopt device 25C2500.This preamplifier is simple and reliable to have very strong driving force, is fit to do the driving of high power amplifier.
The operation principle of foregoing circuit is:
The square-wave signal that the 40MHz crystal oscillator produces, 8 digit counters through any frequency division produce required signal frequency, and enumerator is made up of 24 binary counters.Frequency division value is controlled by manual toggle switch, and square-wave signal drives the prime input of delivering to power amplifier through phase inverter shaping and 0C door.
The prime input of power amplifier is adopted and is adjusted the high speed photo coupling isolation, to reduce mutual interference.Power amplifier is the single supply push pull mode.Two pipes are worked respectively up and down, on when managing conducting, following pipe ends alternation.Deliver to the driving stage input of upper and lower two tube power pipes through phase inverter through the square-wave signal of optocoupler, driving stage is made up of three high speed low-power transistors one power field effect pipe of merely hitting, the first order of three audions is colelctor electrode output, two, three grades are emitter follower output, so that enough drive currents to be provided, in power field effect pipe be operated on off state, adopts transformer coupledly, the front and back level kept apart simultaneously for high power valve provides enough voltage and current drivings.High-power field effect transistor also workers on off state, when last pipe conducting, on the whole heavy loads of supply voltage (transducer).To load charging, when last pipe closes, during following pipe conducting, load (transducer) is gone up the voltage waveform of formation and signal same frequency like this by tube discharge down in load (transducer), and load (transducer) becomes acoustic energy to launch this power conversion.
Power amplifier adopts high-power FET to recommend output, and its output is closed with the direct Rhizoma Nelumbinis of transducer, and this power amplifier is made up of No. 6 amplifiers, and its characteristics are:
Frequency: 1-2MHz (can set arbitrarily)
Power output: 1000-2000 watt (can regulate continuously)
Close with the direct Rhizoma Nelumbinis of load, adopted best matching technique,, have very high anti-jamming capacity to obtain higher efficient.
This power amplifier adopts small-signal isolation technology and high power electric power supply system to move back the Rhizoma Nelumbinis technology from global design, as shown in Figure 7, originally moves back Rhizoma Nelumbinis and has adopted common mode to move back the Rhizoma Nelumbinis technology, not only all can suppress its interference to power supply to ground wire.In order to suppress strong signal weak signal is disturbed, signal source has been adopted isolation technology, to improve stability, the reliability of whole system.
3. high-strength focused transducer 3: high-strength focused transducer is by 200 20 * 20mm
2Transducing unit group 18 form, transducing unit 16 adopts parallel connection or the orderly surfaces that are arranged in Internal Spherical Surface of series system, forms the transducing cell array of Internal Spherical Surface emission.The centre of sphere of Internal Spherical Surface both had been the focus 5 of transducing cell array, as shown in Figure 2.The rated power of transducing unit 16 is 8 watts, and therefore the ultrasonic energy in the unit emission is little, can not damage tissue in its propagation distance, reduces side effect generation in the body.The concentration of energy of having only all transducer units 16 is in focus 5, and the energy of focus 5 will be 8 * 200=1600 watt a electrical power.Become the energy of enough elimination cancerous cell.For guaranteeing that enough big electrical power focuses on; We adopt the mono signal source, guarantee in same media, and transducing unit 16 can phase place be sent to focus to energy, generation unit energy Overlay in the same manner.Thereby reach high-strength focused effect.The array of transducing is formed two kinds of methods: a kind of is that transducing unit 16 directly is contained in the Internal Spherical Surface surface, forms a global focus transducer 3.It is non-adjustable that this kind transducer focuses on focus, decides according to the technological level of transducing unit 16 viscosity; Another kind is that transducing unit 16 is divided into some groups, each group unit is parallel on the strip balance weight body 15 of Internal Spherical Surface, some balance weight body 15 evenly are fixed on the spherical shape that forms on the circular support 14,18 structures of assembling loam cake are at transducer 3 again, and the centre of sphere both had been the focus 5 of transducer arrays.It is adjustable that this kind focuses on focus 5, can reach desirable focus requirement, but the technology trouble.
Transducing unit 16: piezoelectric ceramics, PZ8
The spherical radius of transducer arrays: 320mm
Transducer arrays chord length: 550mm
Transducer arrays focal spot size: 2 * 2 * 10mm
3
4. the ultrasonic propagation dielectric 11, are made up of with the energy attenuation in the transmission of minimizing sound wave and the space of sound wave entrant sound capsule and distilled water to reflect.Water pocket reaches the minimum effect of ultrasonic energy loss between transducer and human body.
5. search three-dimensional motion device 8 automatically: B-mode ultrasound tomography positioner 1 locks relatively for focused transducer focus 5, and mobile transducer 3 itself both had been mobile B-mode ultrasound tomography scanning plane.Three-dimensional motion device 8 by pico computer 2 control step motors as actuating unit.Computer is with three-dimensional result of calculation, and the notice servomotor promotes transducer 3 by leading screw and does three-dimensional motion, finishes scanning, search work to tumor and focus.In time, accurately focus is positioned tumor site.Simultaneously, in the therapeutic process, because ultrasonication face is less than the tumor focus face, the effective moving focal point of three-dimensional motion 5 positions are kill cancer cell and pathological changes all sidedly.Effective moving range in the three-dimensional motion:
X＝100mm
Y＝100mm
Z=100mm trueness error ± 0.5mm.
6. microcomputer: the present invention is provided with a microcomputer, and it mainly is to finish each data input of all control functions of the present invention, handle various data outputs and showing automatically.
7. flowing water ancillary equipment: comprise therapeutic bed (7), water pocket is changed and Current Control platform etc.The relation of said system is seen Fig. 1.
The equipment use: with patient 6 with the appropriate location by being put on the therapeutic bed 7, abdominal part (or other therapeutic domain) is placed in the therapeutic bed 7 water pocket districts.Open the B-mode ultrasound tomography diagnostic system, moving three dimension automatic positioning equipment 8, intraperitoneal tumor and focus are searched in scanning.
After finding tumor, focus 5 labellings (screen device+word shows) of B-mode ultrasound tomography scanning plane are moved on the knub position.
Open ultrasound wave and take place and power transmitter, under the effect of periodic Control, launch ultrasound wave continuously to focus.Per 20 minutes is a course of treatment.
According to the lesion tissue difference, regulate " power emission shelves ", to regulate transmitting power to reach optimum efficiency.
The present invention mainly utilizes the absorption characteristic of biological tissue to energy, and the ultrasonic energy of injecting tissue will become heat energy, and its temperature is raise, and both Sheng Wu heat effect to reach the necessary temperature of tumor thermotherapy, was generally 42 ℃-44 ℃.The present invention adopts the way of same phase focused sound waves, concentrates on accumulation with making energy high strength, act in the diseased region, but not the diseased region damage is less, reaches ideal thermotherapy effect.
Utilize same device, change tranmitting frequency and power, can produce the effect of ultrasonic rubble.Therefore the present invention is also applicable to the relevant testimony and the project organization of medical external supersonic lithotrite.
Claims (5)
1. medical external supersonic therapy apparatus, it is characterized in that it includes B ultrasonic tumor-localizing device, ultrasound wave generation, discharger, high-strength ultrasonic focused transducer, sonic propagation dielectric and from the motion tracking three-dimensional motion device, said ultrasound wave takes place, discharger is to include: signal source, power amplification circuit and control circuit and signal source is to guarantee that the same phase ultrasonic signal takes place, and its frequency is between 1MHz to 2MHz; Control circuit have control location, regularly, the effect of energy adjustment, and directly by computer control; Power amplifier can produce power emission periodically, and the emission cycle can be adopted two cover high frequency power amplifier, radiation patterns continuously as required by computer settings; Said high-strength focused transducer is made up of transducer unit, and transducer unit employing parallel connection or serial connection mode are arranged in the surface of Internal Spherical Surface in an orderly manner, forms the transmitter unit array of Internal Spherical Surface; Also can adopt the transducing unit is divided into some groups, each group unit is parallel on the strip balance weight body of Internal Spherical Surface, more some balance weight body evenly is fixed on the spherical shape that forms on the circular support; Said ultrasonic propagation dielectric then stays water to be formed by entrant sound capsule and steaming; Said three-dimensional motion device, it is a kind of actuating unit by computer-controlled servo motor, it can be automatically along X, Y, three directions of Z move affected area in focus.
2. by the said medical external supersonic therapy apparatus of claim 1, it is characterized in that said ultrasound wave takes place, discharger, it includes: signal source, control circuit, altofrequency amplifier and power governor.
3. by the said medical external supersonic therapy apparatus of claim 1, it is characterized in that said high-strength focused transducer, it is by 200 20 * 20mm
2Parallel connection of transducing unit or the series system surface that is arranged in Internal Spherical Surface, the unitary rated output of each transducing is 8 watts; The transducing unit further is divided into some groups, and each group unit is parallel on the strip balance weight body of Internal Spherical Surface, some balance weight body evenly is fixed on forms the Internal Spherical Surface shape on the circular support again.
4. by the said medical external supersonic therapy apparatus of claim 1, it is characterized in that said ultrasonic propagation dielectric, it is made up of entrant sound glue and distilled water.
5. by the said medical external supersonic therapy apparatus of claim 1, it is characterized in that said three-dimensional motion device, under computer control, it can be automatically along the steering handle of x.y.z affected area in focus.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 96114078 CN1073453C (en) | 1996-12-27 | 1996-12-27 | In vitro supersonic therapeutical instrument for medical purpose |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96114078 CN1073453C (en) | 1996-12-27 | 1996-12-27 | In vitro supersonic therapeutical instrument for medical purpose |
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| CN1185982A true CN1185982A (en) | 1998-07-01 |
| CN1073453C CN1073453C (en) | 2001-10-24 |
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| CN 96114078 Expired - Fee Related CN1073453C (en) | 1996-12-27 | 1996-12-27 | In vitro supersonic therapeutical instrument for medical purpose |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999037364A1 (en) * | 1998-01-25 | 1999-07-29 | Chongqing Hifu Technology Co., Ltd. | A high intensity focused ultrasound system for scanning and curing tumor |
| WO2007012260A1 (en) * | 2005-07-29 | 2007-02-01 | Chongqing Ronghai Medical Ultrasound Industry Ltd. | Mri-guided focusing ultrasound therapeutic system with high intensity |
| CN100384493C (en) * | 2004-02-20 | 2008-04-30 | 吴巍 | Hand-held ultra sonic therapeutic head with coupling and buffering pratective device |
| CN100408128C (en) * | 2004-04-29 | 2008-08-06 | 朱念麟 | Focus adjustable ultrasonic apparatus with low energy and its application for treating leukemia in vitro |
| CN100415318C (en) * | 2000-04-21 | 2008-09-03 | 特克斯索尼克斯公司 | Systems and methods for creating longer necrosed volumes using phased array focused ultrasound system |
| CN100438941C (en) * | 2004-06-17 | 2008-12-03 | 上海交通大学 | Ultrasonic heat treatment system for mouth cavity and maxillofacial malignant tumor |
| CN101578653A (en) * | 2007-01-11 | 2009-11-11 | 弗雷泽纽斯医疗保健德国有限公司 | Use of a directed sound source, medical treatment station and medical treatment room |
| CN101467910B (en) * | 2007-12-28 | 2010-09-29 | 北京奥麦特科技有限公司 | In vivo ultrasound lithotripter |
| CN102327151A (en) * | 2010-07-13 | 2012-01-25 | 东莞宜安科技股份有限公司 | Medical degradable magnesium alloy oxide film system of extracorporeal shock wave lithotripsy |
| CN105854186A (en) * | 2016-03-15 | 2016-08-17 | 西安邮电大学 | Intermediate and terminal cancer treatment equipment based on quantum superstring engine |
| CN106955139A (en) * | 2017-05-05 | 2017-07-18 | 浙江荣信医疗科技有限公司 | A kind of internal rubble instrument circuit and pulsed discharge lithotripsy method |
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| CN109433570A (en) * | 2019-01-07 | 2019-03-08 | 中国科学院声学研究所北海研究站 | A kind of polyhedron spherical transducer and preparation method thereof |
| CN111262579A (en) * | 2020-03-31 | 2020-06-09 | 杭州国彪超声设备有限公司 | Two-dimensional ultrasonic device frequency tracking and phase control circuit based on FPGA |
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| CN100356895C (en) * | 2003-01-31 | 2007-12-26 | 株式会社日立医药 | Ultrasonic probe and ultrasonic device |
| US20070060906A1 (en) * | 2003-08-18 | 2007-03-15 | Wei Wu | Method, reagent, and device for embolizing blood vessels in tumors with ultrasonic radiation micro-bubble reagent |
-
1996
- 1996-12-27 CN CN 96114078 patent/CN1073453C/en not_active Expired - Fee Related
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999037364A1 (en) * | 1998-01-25 | 1999-07-29 | Chongqing Hifu Technology Co., Ltd. | A high intensity focused ultrasound system for scanning and curing tumor |
| CN1058905C (en) * | 1998-01-25 | 2000-11-29 | 重庆海扶(Hifu)技术有限公司 | High-intensity focus supersonic tumor scanning therapy system |
| CN100415318C (en) * | 2000-04-21 | 2008-09-03 | 特克斯索尼克斯公司 | Systems and methods for creating longer necrosed volumes using phased array focused ultrasound system |
| CN100384493C (en) * | 2004-02-20 | 2008-04-30 | 吴巍 | Hand-held ultra sonic therapeutic head with coupling and buffering pratective device |
| CN100408128C (en) * | 2004-04-29 | 2008-08-06 | 朱念麟 | Focus adjustable ultrasonic apparatus with low energy and its application for treating leukemia in vitro |
| CN100438941C (en) * | 2004-06-17 | 2008-12-03 | 上海交通大学 | Ultrasonic heat treatment system for mouth cavity and maxillofacial malignant tumor |
| WO2007012260A1 (en) * | 2005-07-29 | 2007-02-01 | Chongqing Ronghai Medical Ultrasound Industry Ltd. | Mri-guided focusing ultrasound therapeutic system with high intensity |
| CN101578653A (en) * | 2007-01-11 | 2009-11-11 | 弗雷泽纽斯医疗保健德国有限公司 | Use of a directed sound source, medical treatment station and medical treatment room |
| CN101467910B (en) * | 2007-12-28 | 2010-09-29 | 北京奥麦特科技有限公司 | In vivo ultrasound lithotripter |
| CN102327151A (en) * | 2010-07-13 | 2012-01-25 | 东莞宜安科技股份有限公司 | Medical degradable magnesium alloy oxide film system of extracorporeal shock wave lithotripsy |
| CN102327151B (en) * | 2010-07-13 | 2015-04-08 | 东莞宜安科技股份有限公司 | Medical degradable magnesium alloy oxide film system of extracorporeal shock wave lithotripsy |
| CN105854186A (en) * | 2016-03-15 | 2016-08-17 | 西安邮电大学 | Intermediate and terminal cancer treatment equipment based on quantum superstring engine |
| CN106955139A (en) * | 2017-05-05 | 2017-07-18 | 浙江荣信医疗科技有限公司 | A kind of internal rubble instrument circuit and pulsed discharge lithotripsy method |
| CN109345912A (en) * | 2018-11-21 | 2019-02-15 | 宁波聚创工业设计有限公司 | A kind of wristband type universal serial milk cow rectum localization examination intelligent tutoring device and teaching method |
| CN109433570A (en) * | 2019-01-07 | 2019-03-08 | 中国科学院声学研究所北海研究站 | A kind of polyhedron spherical transducer and preparation method thereof |
| CN109433570B (en) * | 2019-01-07 | 2023-06-16 | 中国科学院声学研究所北海研究站 | Polyhedral spherical transducer and manufacturing method thereof |
| CN111262579A (en) * | 2020-03-31 | 2020-06-09 | 杭州国彪超声设备有限公司 | Two-dimensional ultrasonic device frequency tracking and phase control circuit based on FPGA |
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Application publication date: 19980701 Assignee: Beijing Zhongke Xinxin Technology Co., Ltd. Assignor: Institute of acoustics, Chinese Academy of Sciences Contract record no.: 2010990000167 Denomination of invention: In vitro supersonic therapeutical instrument for medical purpose Granted publication date: 20011024 License type: Exclusive License Record date: 20100406 |
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