CN1569055A - Chinese traditional medicine for treating Tourette - Google Patents

Abstract

The invention provides a Chinese traditional medicine for treating Tourette's disease, wherein the medicine comprises root of herbaceous peony, gastrodia tuber, grassleaved sweetflag rhizome, pearl powder, polygala root.

Description

A kind of Chinese medicine for the treatment of multiple pumping symptoms

Technical field: the present invention relates to Chinese medicine, particularly treat the Chinese medicine of multiple pumping symptoms.

Background technology: the Western medicine for the treatment of Gilles de la Tourette's syndrome at present generally all has side effect, and the Chinese medicine curative effect is all undesirable, and addressing this problem becomes urgent need.

The content of invention: overcome the deficiency that prior art exists, propose a kind of Chinese medicine of treatment Gilles de la Tourette's syndrome evident in efficacy.This Chinese medicine is made of following composition: Radix Paeoniae Alba 2--10 part, Rhizoma Gastrodiae 2--8 part, Rhizoma Acori Graminei 2--8 part, Margarita 2--10 part, Radix Polygalae 1--7 part.Its production technology is: the Radix Paeoniae Alba is added 65% alcohol reflux 3 times, and extraction time is 1.5,1.0,1.0 hours, merges reflux extracting liquid, reclaims ethanol, is concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Rhizoma Gastrodiae, Rhizoma Acori Graminei, Concha Margaritifera, Radix Polygalae add 6 times of amounts of water, decoct 3 times, each 1 hour, gradation filtered, merging filtrate, and be concentrated into the clear paste of relative density 1.14-1.16 (80C), and add ethanol and make and contain the alcohol amount and reach 60%, left standstill 24 hours, filter, reclaim ethanol, be concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Get above two kinds of fine powders and add auxiliary materials and mixing, use 75% alcohol granulation, drying is pressed into 1000, the bag film-coat, or incapsulate 1000, promptly.Chinese medicine of the present invention has the effect of nourishing blood to suppress the hyperactive liver, suppressing liver-YANG owing to containing Radix Paeoniae Alba nature and flavor hardship, acid, being slightly cold; Because it is sweet, flat to contain the Rhizoma Gastrodiae nature and flavor, specially goes into Liver Channel, has the effect of relieving spasm by subduing liver-wind, suppressing the hyperactive liver and subsiding YANG; Contain Rhizoma Acori Graminei acrid in the mouth, temperature, have the wet effect of air slaking of eliminating phlegm for resuscitation, loose; The Concha Margaritifera nature and flavor are salty, cold, with the function assistant principal drug assistance Radix Paeoniae Alba of its suppressing the hyperactive liver and subsiding YANG, the effect of ministerial drug Rhizoma Gastrodiae endogenous wind stopping stop; Radix Polygalae nature and flavor suffering, hardship, tepor are helped the thinking that helps the resistance of ministerial drug Rhizoma Acori Graminei tonneau fraud with its function of having one's ideas straightened out of eliminating the phlegm, so the two adjuvant drug that is all in the side.The function that the result of above-mentioned every medicine comprehensive function makes the present invention have suppressing the hyperactive liver to relieve the wind syndrome, eliminate phlegm for resuscitation.Liver-yang is stabilized liver-wind and is put out, and then twitches to such an extent that end; The stagnation of phlegm tonneau of must having one's ideas straightened out, mind winner then, " main bright then peace " down independently do not twitch and sounding then can be well controlled.

The specific embodiment: most preferred embodiment of the present invention, get Radix Paeoniae Alba 600g, Rhizoma Gastrodiae 300g, Rhizoma Acori Graminei 400g, Concha Margaritifera 600g, Radix Polygalae 300g.Its production technology is: the Radix Paeoniae Alba is added 65% alcohol reflux 3 times, and extraction time is 1.5,1.0,1.0 hours, merges reflux extracting liquid, reclaims ethanol, is concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Rhizoma Gastrodiae, Rhizoma Acori Graminei, Concha Margaritifera, Radix Polygalae add 6 times of amounts of water, decoct 3 times, each 1 hour, gradation filtered, merging filtrate, and be concentrated into the clear paste of relative density 1.14-1.16 (80C), and add ethanol and make and contain the alcohol amount and reach 60%, left standstill 24 hours, filter, reclaim ethanol, be concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Get above two kinds of fine powders and add auxiliary materials and mixing, use 75% alcohol granulation, drying is pressed into 1000, the bag film-coat, or incapsulate 1000, promptly.

Another embodiment of the present invention is got Radix Paeoniae Alba 200g, Rhizoma Gastrodiae 100g, Rhizoma Acori Graminei 200g, Concha Margaritifera 1000g, Radix Polygalae 100g.Its production technology is: the Radix Paeoniae Alba is added 65% alcohol reflux 3 times, and extraction time is 1.5,1.0,1.0 hours, merges reflux extracting liquid, reclaims ethanol, is concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Rhizoma Gastrodiae, Rhizoma Acori Graminei, Concha Margaritifera, Radix Polygalae add 6 times of amounts of water, decoct 3 times, each 1 hour, gradation filtered, merging filtrate, and be concentrated into the clear paste of relative density 1.14-1.16 (80C), and add ethanol and make and contain the alcohol amount and reach 60%, left standstill 24 hours, filter, reclaim ethanol, be concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Get above two kinds of fine powders and add auxiliary materials and mixing, use 75% alcohol granulation, drying is pressed into 1000, the bag film-coat, or incapsulate 1000, promptly.

The 3rd embodiment of the present invention gets Radix Paeoniae Alba 1000g, Rhizoma Gastrodiae 700g, Rhizoma Acori Graminei 800g, Concha Margaritifera 200g, Radix Polygalae 700g.Its production technology is: the Radix Paeoniae Alba is added 65% alcohol reflux 3 times, and extraction time is 1.5,1.0,1.0 hours, merges reflux extracting liquid, reclaims ethanol, is concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Rhizoma Gastrodiae, Rhizoma Acori Graminei, Concha Margaritifera, Radix Polygalae add 6 times of amounts of water, decoct 3 times, each 1 hour, gradation filtered, merging filtrate, and be concentrated into the clear paste of relative density 1.14-1.16 (80C), and add ethanol and make and contain the alcohol amount and reach 60%, left standstill 24 hours, filter, reclaim ethanol, be concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Get above two kinds of fine powders and add auxiliary materials and mixing, use 75% alcohol granulation, drying is pressed into 1000, the bag film-coat, or incapsulate 1000, promptly.

Usage and consumption: oral, one time 4,2 times on the one, sooner or later using warm water delivery service, a course of treatment after meal was 4 weeks; Or follow the doctor's advice.

Estimate the clinical medicine safety of Chinese medicine of the present invention, it carried out toxicity test research, be reported as follows:

1. be subjected to test product: a kind of Chinese medicine every day for the treatment of Gilles de la Tourette's syndrome 2 times, each 2 grams.

2. experimental animal: the white mice of Kunming kind, body weight 18-22 gram, male and female dual-purpose.

3. the preparation of dosage and test drug: the Chinese medicine of getting the treatment Gilles de la Tourette's syndrome.4 grams are put and are added the 10.0ml distilled water in the mortar and be uniformly dispersed, and make solution.Administering mode is a gastric infusion.

The mensuration of median lethal dose(LD 50)

Get 9 of mices, divide three groups, but fail to find out the dosage of 100% animal dead.

Select 50 of the healthy mices of body weight 20 ± 2g for use, male and female half and half are divided into five groups, once at random

Oral administration gavage administration, dosage are by geometric progression, and maximum dose level calculates with the maximum volume that can accept.Observed 7 days none death as a result after the administration.

Mtd test

Select 20 of healthy mices, male and female half and half, normally raise 1 after, administration is 2 times in 24 hours, observes continuously 7 12 hours blanking times, does not see untoward reaction and death condition, can think the oral avirulence of this medicine.

The maximum tolerated dose multiple is calculated as follows:

$=\frac{0.8\×3\×24\%}{20}\×\frac{60000}{6\×3\×0.4}$

$=240$ Doubly

Calculate if obey 4 grams every day by the adult, the result is 240 times of normal clinical dosage, illustrates that a kind of Chinese medicine for the treatment of Gilles de la Tourette's syndrome has safety.

A kind of Chinese medicine clinical summary for the treatment of Gilles de la Tourette's syndrome

One group to the statistics in the Gilles de la Tourette's syndrome patients clinical observations.This organizes 5% case for observing the patient of treatment.Man's 43 examples wherein, women 16 examples, in age 4-9 year, wherein Therapeutic Method is the patient to be divided into two groups at random, and 39 examples are organized in treatment, obey capsule of the present invention, and every day twice, each four, 30 days is a course of treatment.Matched group 20 examples are taken other medicine, and 30 days is a course of treatment, withdraws other medicines before the administration, all do inspection before and after the treatment, and the result shows that the treatment group effective percentage of taking Chinese medicine of the present invention is 98%, and matched group does not have obvious effects.

Claims (3)

1, a kind of Chinese medicine for the treatment of multiple pumping symptoms, it is characterized in that it is made of following composition: Radix Paeoniae Alba, Rhizoma Gastrodiae, Rhizoma Acori Graminei, Concha Margaritifera, Radix Polygalae, the weight proportion of its composition be: Radix Paeoniae Alba 2--8 part, Rhizoma Gastrodiae 1--7 part, Rhizoma Acori Graminei 2--8 part, Concha Margaritifera 2--10 part, Radix Polygalae 1--7 part.

2, according to the Chinese medicine of the described treatment multiple pumping symptoms of claim 1, it is characterized in that the weight proportion of each composition is: 6 parts of the Radix Paeoniae Albas, 3 parts in Rhizoma Gastrodiae, 4 parts of Rhizoma Acori Graminei, 6 parts of Concha Margaritiferas, 3 parts of Radix Polygalaes.

3, according to the Chinese medicine of the described treatment multiple pumping symptoms of claim 1, it is characterized in that production technology is: the Radix Paeoniae Alba is added 65% alcohol reflux 3 times, extraction time is 1.5,1.0,1.0 hours, merge reflux extracting liquid, reclaim ethanol, be concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Rhizoma Gastrodiae, Rhizoma Acori Graminei, Concha Margaritifera, Radix Polygalae add 6 times of amounts of water, decoct 3 times, each 1 hour, gradation filtered, merging filtrate, and be concentrated into the clear paste of relative density 1.14-1.16 (80C), and add ethanol and make and contain the alcohol amount and reach 60%, left standstill 24 hours, filter, reclaim ethanol, be concentrated into the clear paste of relative density 1.10-1.15 (50C), spray drying; Get above two kinds of fine powders and add auxiliary materials and mixing, use 75% alcohol granulation, drying is pressed into 1000, the bag film-coat, or incapsulate 1000, promptly.