CN1565560A - Anti-inflammation and antipyretic medicine - Google Patents
Anti-inflammation and antipyretic medicine Download PDFInfo
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- CN1565560A CN1565560A CN 03135239 CN03135239A CN1565560A CN 1565560 A CN1565560 A CN 1565560A CN 03135239 CN03135239 CN 03135239 CN 03135239 A CN03135239 A CN 03135239A CN 1565560 A CN1565560 A CN 1565560A
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- radix
- drop pill
- medicine
- rhizoma rhei
- cortex phellodendri
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Abstract
The invention discloses an nnti-inflammation and antipyretic medicine, which is prepared through modifying the existing dosage types and preparing drop pills. The invention realizes the advantages of simple process for manufacturing, lower cost, better pharmaceutical stability, longer effective period, small amount of administration, shorter disintegration time, and fast effect.
Description
Technical field
The present invention relates to a kind of medicine of anti-inflammatory antipyretic, particularly a kind of medicine that contains the anti-inflammatory antipyretic of Chinese herbal medicine extracting composition.
Background technology
SIJI SANHUANG WAN, four seasons SANHUANG PIAN, four seasons Sanhuang capsules and four seasons SANHUANG soft capsule are one of Chinese patent medicines commonly used of present anti-inflammatory antipyretic, relieving constipation diuretic, contain Chinese medicines such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae in the prescription, the definite curative effect of its anti-inflammatory antipyretic, relieving constipation diuretic, clinical practice is for many years confirmed by medical circle, and is long lasting.Be respectively ministry standard (pill and tablet) and national new drug standard (capsule and soft capsule) is recorded.
But existing SIJI SANHUANG WAN is owing to being directly medicated powder mixing pill to be got, and without any extraction process, so have following shortcoming: dose is big, and effect duration is short, grows microorganism easily, disintegration time long (more than 30 minutes), and onset is slow.
Four seasons SANHUANG PIAN, four seasons Sanhuang capsules and four seasons SANHUANG soft capsule are to change dosage form and get on the basis of SIJI SANHUANG WAN, overcome to a certain extent that SIJI SANHUANG WAN conventional dosage forms dose is big, effect duration is short, grow above-mentioned defective such as microorganism easily, but, they still exist disintegration time to grow (more than 15 minutes), onset is shortcoming more slowly, and their preparation technology is comparatively complicated, and production cost is higher.
Summary of the invention
The objective of the invention is to above-mentioned shortcoming at existing medicine SIJI SANHUANG WAN, four seasons SANHUANG PIAN, four seasons Sanhuang capsules and four seasons SANHUANG soft capsule, provide a kind of technology simple, cost is relatively low, medicine stability is better, effect duration is longer, dose is less, and disintegration time is short, the i.e. new drug formulation four seasons three skullcap dripping pills of advantages such as disintegrate thereby onset be very fast fully basically about 3 minutes.
Solution of the present invention is to form according to the prescription of existing medicine SIJI SANHUANG WAN, four seasons SANHUANG PIAN, four seasons Sanhuang capsules and four seasons SANHUANG soft capsule, adds appropriate amount of auxiliary materials, through certain processing technique, makes drops.Its preparation method may further comprise the steps:
(1) Radix Et Rhizoma Rhei in the described prescription, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae four flavor Chinese medicines are pulverized, mixing, make solvent with 0%～100% ethanol or ethyl acetate, carry out percolation extraction or reflux, extract, or immersion extraction or use water boiling and extraction, collect extracting solution, and reclaim solvent or concentrated extracting solution, obtain the extractum of Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae and Fructus Gardeniae four flavor Chinese medicines;
(2) described extractum is joined in the drop pill substrate of molten condition, mix homogeneously obtains waiting to drip the medicinal liquid of making; Wherein drop pill substrate is good with water-soluble fluidity substrate, as Macrogol 4000 or 6000 or glycerin gelatine etc.;
(3) described medicinal liquid is made drop pill in following of the condition that keeps 60-130 ℃ of steady temperature, through cooling off, being drying to obtain.
The invention has the beneficial effects as follows: simplify technology, reduced cost, improved medicine stability, and taking convenience, onset is very fast.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
The present invention changes dosage form in existing medicine SIJI SANHUANG WAN, four seasons SANHUANG PIAN, four seasons Sanhuang capsules and four seasons SANHUANG soft capsule, makes drops and gets.
Embodiment one
Radix Et Rhizoma Rhei in the prescription, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae four flavor Chinese medicines are pulverized, and mixing is made solvent with 70% ethanol or ethyl acetate, carries out reflux, extract,, collects extracting solution, and reclaims ethanol, obtains the extractum of Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae and Fructus Gardeniae four flavor Chinese medicines; Described extractum is joined in the drop pill substrate Macrogol 4000 of molten condition, mix homogeneously obtains waiting to drip the medicinal liquid of making; Described medicinal liquid is made drop pill in following of the condition that keeps 60 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment two
Radix Et Rhizoma Rhei in the prescription, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae four flavor Chinese medicines are pulverized, and mixing is made solvent with ethyl acetate, carries out percolation and extracts, and collects extracting solution, and reclaims ethyl acetate, obtains the extractum of Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae and Fructus Gardeniae four flavor Chinese medicines; Described extractum is joined in the drop pill substrate polyethylene glycol 6000 of molten condition, mix homogeneously obtains waiting to drip the medicinal liquid of making; Described medicinal liquid is made drop pill in following of the condition that keeps 130 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment three
Radix Et Rhizoma Rhei in the prescription, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae four flavor Chinese medicines are pulverized, and mixing uses water as solvent, decocts extraction, collects and concentrated extracting solution, obtains the extractum of Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae and Fructus Gardeniae four flavor Chinese medicines; Described extractum is joined in the drop pill substrate glycerin gelatine of molten condition, mix homogeneously obtains waiting to drip the medicinal liquid of making; Described medicinal liquid is made drop pill in following of the condition that keeps 90 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment four
Radix Et Rhizoma Rhei in the prescription, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae four flavor Chinese medicines are pulverized, and mixing is made solvent with 95% ethanol, soaks extraction, collects extracting solution, and reclaims ethanol, obtains the extractum of Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae and Fructus Gardeniae four flavor Chinese medicines; Described extractum is joined in the drop pill substrate Macrogol 4000 of molten condition, mix homogeneously obtains waiting to drip the medicinal liquid of making; Described medicinal liquid is made drop pill in following of the condition that keeps 75 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment five
Radix Et Rhizoma Rhei in the prescription, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae four flavor Chinese medicines are pulverized, and mixing is made solvent with 50% ethanol, carries out percolation and extracts, and collects extracting solution, and reclaims ethanol, obtains the extractum of Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae and Fructus Gardeniae four flavor Chinese medicines; Described extractum is joined in the drop pill substrate glycerin gelatine of molten condition, mix homogeneously obtains waiting to drip the medicinal liquid of making; Described medicinal liquid is made drop pill in following of the condition that keeps 110 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Claims (4)
1. the medicine of an anti-inflammatory antipyretic contains Chinese medicines such as Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae in the prescription, it is characterized in that described medicine is made drops.
2. medicine according to claim 1 is characterized in that its preparation method may further comprise the steps:
(1) Radix Et Rhizoma Rhei in the described prescription, Cortex Phellodendri, Radix Scutellariae, Fructus Gardeniae four flavor Chinese medicines are pulverized, mixing, make solvent with 0%～100% ethanol or ethyl acetate, carry out percolation extraction or reflux, extract, or immersion extraction or use water boiling and extraction, collect extracting solution, and reclaim solvent or concentrated extracting solution, obtain the extractum of Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae and Fructus Gardeniae four flavor Chinese medicines;
(2) described extractum is joined in the drop pill substrate of molten condition, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3) described medicinal liquid is made drop pill in following of the condition that keeps 60-130 ℃ of steady temperature, through cooling off, being drying to obtain.
3. medicine according to claim 2 is characterized in that drop pill substrate described in the described method is water-soluble fluidity substrate.
4. medicine according to claim 3 is characterized in that drop pill substrate described in the described method is Macrogol 4000 or 6000 or glycerin gelatine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135239 CN1565560A (en) | 2003-06-18 | 2003-06-18 | Anti-inflammation and antipyretic medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135239 CN1565560A (en) | 2003-06-18 | 2003-06-18 | Anti-inflammation and antipyretic medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1565560A true CN1565560A (en) | 2005-01-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03135239 Pending CN1565560A (en) | 2003-06-18 | 2003-06-18 | Anti-inflammation and antipyretic medicine |
Country Status (1)
| Country | Link |
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| CN (1) | CN1565560A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396465B (en) * | 2008-10-09 | 2010-12-29 | 刘运波 | Traditional Chinese medicine for treating chronic suppurative tonsillitis |
| CN101632737B (en) * | 2008-07-23 | 2012-01-25 | 吉林一正药业集团有限公司 | Medicament for relieving pain of human body and preparation method thereof |
-
2003
- 2003-06-18 CN CN 03135239 patent/CN1565560A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632737B (en) * | 2008-07-23 | 2012-01-25 | 吉林一正药业集团有限公司 | Medicament for relieving pain of human body and preparation method thereof |
| CN101396465B (en) * | 2008-10-09 | 2010-12-29 | 刘运波 | Traditional Chinese medicine for treating chronic suppurative tonsillitis |
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