CN1565559A - Medicine for treating cold and cough - Google Patents
Medicine for treating cold and cough Download PDFInfo
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- CN1565559A CN1565559A CN 03135238 CN03135238A CN1565559A CN 1565559 A CN1565559 A CN 1565559A CN 03135238 CN03135238 CN 03135238 CN 03135238 A CN03135238 A CN 03135238A CN 1565559 A CN1565559 A CN 1565559A
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- radix
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- drop pill
- pericarpium citri
- citri reticulatae
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Abstract
The invention discloses a medicine for treating cold and cough which is prepared through modifying the existing dosage types and preparing drop pills. The invention realizes the advantages of simpler process, lower cost, easy and small amount administration, convenience in transportation and carrying, better pharmaceutical stability, shorter disintegration time, and quicker action.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of cold cough, particularly a kind of medicine that is used for the treatment of cold cough that contains the Chinese herbal medicine extracting composition.
Background technology
Tongxuan lifei pills, Tongxuanlifei sheet, Tongxuanlifei oral liquid, Tongxuanlifei electuary (cough due to common cold electuary) and Tongxuanlifei cream are one of Chinese patent medicines commonly used that is used for the treatment of at present cold cough, contain Chinese medicines such as Folium Perillae, Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Radix Scutellariae in the prescription, have effects such as the cold expelling of inducing sweat, lung qi dispersing antitussive, can be used for treating cold cough, fever with chills, the nasal obstruction watery nasal discharge, it is lossless to have a headache, diseases such as limb aching pain.Be respectively one one of Chinese Pharmacopoeia version in 2000, Sichuan Province＜Chinese traditional patent formulation preparation 93 editions 〉, become a full member standard (the 11), Chinese traditional patent formulation preparation promulgated by the ministries or commissions of the Central Government (the 7th) and Chinese traditional patent formulation preparation promulgated by the ministries or commissions of the Central Government (the 17) of Ministry of Public Health new drug record.
But existing tongxuan lifei pills is owing to being directly medicated powder mixing pill to be got, and without any extraction process, so have following shortcoming: dose is big, and effect duration is short, grows microorganism easily, disintegration time long (more than 30 minutes), and onset is slow.
The Tongxuanlifei sheet is to change dosage form and get on the basis of tongxuan lifei pills, has overcome to a certain extent that tongxuan lifei pills conventional dosage forms dose is big, effect duration lacks, has grown above-mentioned defective such as microorganism easily.But it still exists disintegration time to grow (more than 15 minutes), and onset is shortcoming more slowly, and its preparation technology is comparatively complicated, and production cost is higher.
The Tongxuanlifei oral liquid belongs to mixture, and its shortcoming mainly is a complex process, and production cost is higher, dose big (a time 10～20ml); In addition, because it is the profit dispersion, usually cause the quality instability, and mouthfeel is not good, transports, carry equal inconvenience because of the profit layering.
The shortcoming of Tongxuanlifei electuary (cough due to common cold electuary) mainly is: dose is big, takes inconvenience, is difficult to preserve volatile oil, quality instability.
Tongxuanlifei cream have complex process, cost height, dose big, transport and carry shortcoming such as inconvenience, and because the sugar content height, it is short to grow microorganism, effect duration easily, and forbids or patient's (as diabetics) of control sugar part intake also should not use for need.
Summary of the invention
The objective of the invention is to above-mentioned shortcoming at existing medicine tongxuan lifei pills, Tongxuanlifei sheet, Tongxuanlifei oral liquid, Tongxuanlifei electuary (cough due to common cold electuary) and Tongxuanlifei cream, provide that a kind of technology is comparatively simple, cost is relatively low, taking convenience and dose is little, transportation and easy to carry, medicine stability is better, effect duration is longer relatively, and disintegration time is short, the i.e. new drug formulation Tongxuanlifei drop pill of advantages such as disintegrate thereby onset be very fast fully basically about 3 minutes.
Solution of the present invention is that existing medicine is made drops.Its preparation method may further comprise the steps:
(1) Folium Perillae in the described prescription, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii four flavor Chinese medicines are pulverized, mixing, adopt the way of distillation to extract volatile oil, distilled water is concentrated into thick paste, and device is preserved in addition, and medicinal residues and Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Radix Glycyrrhizae, the Rhizoma Pinelliae, Poria and Radix Scutellariae seven flavor Chinese medicines mix, carry out percolation extraction or reflux, extract, or immersion with 0%～100% ethanol and extract or use water boiling and extraction, collect extracting solution, and reclaim solvent or concentrated extracting solution, obtain the extractum of described each Chinese medicine;
(2) described thick paste and extractum are joined in the drop pill substrate of molten condition, mix homogeneously adds the volatile oil of Folium Perillae, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii again, and mix homogeneously obtains waiting the medicinal liquid of the system of dripping; Wherein said drop pill substrate is good with water-soluble base, as Macrogol 4000 or 6000 or glycerin gelatine etc.;
(3) described medicinal liquid is made drop pill in following of the condition that keeps 60-100 ℃ of steady temperature, through cooling off, being drying to obtain.
The invention has the beneficial effects as follows: simplified technology, reduced cost, improved medicine stability, and taken, transport and carry all comparatively convenient, onset is very fast; In addition, owing to do not contain sugar, the former patient who yet forbids or control the sugar intake applicable to need.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
The present invention changes dosage form with existing medicine tongxuan lifei pills, Tongxuanlifei sheet, Tongxuanlifei oral liquid, Tongxuanlifei electuary (cough due to common cold electuary) and Tongxuanlifei cream, makes drops and gets.
Embodiment one
Folium Perillae in the prescription, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii four flavor Chinese medicines are pulverized, mixing, adopt the way of distillation to extract volatile oil, distilled water is concentrated into thick paste, and device is preserved in addition, and medicinal residues and Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Radix Glycyrrhizae, the Rhizoma Pinelliae, Poria and Radix Scutellariae mix, add suitable quantity of water, decoct extraction, collect and concentrated extracting solution, obtain the extractum of described each Chinese medicine; Described thick paste and extractum are joined in the drop pill substrate Macrogol 4000 of molten condition, and mix homogeneously adds the volatile oil of Folium Perillae, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii again, and mix homogeneously obtains waiting the medicinal liquid of the system of dripping; Described medicinal liquid is made drop pill in following of the condition that keeps 80 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment two
Folium Perillae in the prescription, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii four flavor Chinese medicines are pulverized, mixing, adopt the way of distillation to extract volatile oil, distilled water is concentrated into thick paste, and device is preserved in addition, and medicinal residues and Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Radix Glycyrrhizae, the Rhizoma Pinelliae, Poria and Radix Scutellariae mix, carrying out percolation with 95% ethanol extracts, collect extracting solution, and reclaim ethanol, obtain the extractum of described each Chinese medicine; Described thick paste and extractum are joined in the drop pill substrate polyethylene glycol 6000 of molten condition, and mix homogeneously adds the volatile oil of Folium Perillae, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii again, and mix homogeneously obtains waiting the medicinal liquid of the system of dripping; Described medicinal liquid is made drop pill in following of the condition that keeps 60 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment three
Folium Perillae in the prescription, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii four flavor Chinese medicines are pulverized, mixing, adopt the way of distillation to extract volatile oil, distilled water is concentrated into thick paste, and device is preserved in addition, and medicinal residues and Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Radix Glycyrrhizae, the Rhizoma Pinelliae, Poria and Radix Scutellariae mix, soak extraction with 40% ethanol, collect extracting solution, and reclaim ethanol, obtain the extractum of described each Chinese medicine; Described thick paste and extractum are joined in the drop pill substrate glycerin gelatine of molten condition, and mix homogeneously adds the volatile oil of Folium Perillae, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii again, and mix homogeneously obtains waiting the medicinal liquid of the system of dripping; Described medicinal liquid is made drop pill in following of the condition that keeps 70 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment four
Folium Perillae in the prescription, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii four flavor Chinese medicines are pulverized, mixing, adopt the way of distillation to extract volatile oil, distilled water is concentrated into thick paste, and device is preserved in addition, and medicinal residues and Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Radix Glycyrrhizae, the Rhizoma Pinelliae, Poria and Radix Scutellariae mix, carry out reflux, extract, with 70% ethanol, collect extracting solution, and reclaim ethanol, obtain the extractum of described each Chinese medicine; Described thick paste and extractum are joined in the drop pill substrate glycerin gelatine of molten condition, and mix homogeneously adds the volatile oil of Folium Perillae, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii again, and mix homogeneously obtains waiting the medicinal liquid of the system of dripping; Described medicinal liquid is made drop pill in following of the condition that keeps 90 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Embodiment five
Folium Perillae in the prescription, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii four flavor Chinese medicines are pulverized, mixing, adopt the way of distillation to extract volatile oil, distilled water is concentrated into thick paste, and device is preserved in addition, and medicinal residues and Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Radix Glycyrrhizae, the Rhizoma Pinelliae, Poria and Radix Scutellariae mix, soak extraction with 85% ethanol, collect extracting solution, and reclaim ethanol, obtain the extractum of described each Chinese medicine; Described thick paste and extractum are joined in the drop pill substrate Macrogol 4000 of molten condition, and mix homogeneously adds the volatile oil of Folium Perillae, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii again, and mix homogeneously obtains waiting the medicinal liquid of the system of dripping; Described medicinal liquid is made drop pill in following of the condition that keeps 100 ± 2 ℃ of steady temperatures, through cooling off, being drying to obtain.
Claims (4)
1. a medicine that is used for the treatment of cold cough contains Chinese medicines such as Folium Perillae, Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Herba Ephedrae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Radix Scutellariae in the prescription, it is characterized in that described medicine is made drops.
2. medicine according to claim 1 is characterized in that its preparation method may further comprise the steps:
(1) Folium Perillae in the described prescription, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii four flavor Chinese medicines are pulverized, mixing, adopt the way of distillation to extract volatile oil, distilled water is concentrated into thick paste, and device is preserved in addition, and medicinal residues and Radix Peucedani, Radix Platycodonis, Semen Armeniacae Amarum, Radix Glycyrrhizae, the Rhizoma Pinelliae, Poria and Radix Scutellariae seven flavor Chinese medicines mix, carry out percolation extraction or reflux, extract, or immersion with 0%～100% ethanol and extract or use water boiling and extraction, collect extracting solution, and reclaim solvent or concentrated extracting solution, obtain the extractum of described each Chinese medicine;
(2) described thick paste and extractum are joined in the drop pill substrate of molten condition, mix homogeneously adds the volatile oil of Folium Perillae, Herba Ephedrae, Pericarpium Citri Reticulatae and Fructus Aurantii again, and mix homogeneously obtains waiting the medicinal liquid of the system of dripping;
(3) described medicinal liquid is made drop pill in following of the condition that keeps 60-100 ℃ of steady temperature, through cooling off, being drying to obtain.
3. medicine according to claim 2 is characterized in that drop pill substrate described in the described method is water-soluble base.
4. medicine according to claim 2 is characterized in that drop pill substrate described in the described method is Macrogol 4000 or 6000 or glycerin gelatine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135238 CN1565559A (en) | 2003-06-18 | 2003-06-18 | Medicine for treating cold and cough |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135238 CN1565559A (en) | 2003-06-18 | 2003-06-18 | Medicine for treating cold and cough |
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| Publication Number | Publication Date |
|---|---|
| CN1565559A true CN1565559A (en) | 2005-01-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03135238 Pending CN1565559A (en) | 2003-06-18 | 2003-06-18 | Medicine for treating cold and cough |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450540C (en) * | 2006-07-14 | 2009-01-14 | 左耀武 | External plaster for treating child cold type cough and preparing method |
-
2003
- 2003-06-18 CN CN 03135238 patent/CN1565559A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450540C (en) * | 2006-07-14 | 2009-01-14 | 左耀武 | External plaster for treating child cold type cough and preparing method |
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