CN1565492A - Gynecopathy treating gelatin and its preparation - Google Patents
Gynecopathy treating gelatin and its preparation Download PDFInfo
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- CN1565492A CN1565492A CN 03124593 CN03124593A CN1565492A CN 1565492 A CN1565492 A CN 1565492A CN 03124593 CN03124593 CN 03124593 CN 03124593 A CN03124593 A CN 03124593A CN 1565492 A CN1565492 A CN 1565492A
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Abstract
The invention relates to a gynecopathy treating gelatin and its preparation, wherein the gel mainly comprises oil of aromatic turmeric and boneol, wherein process modification is introduced into the conventional suppositorium and foam agent production process, it has the advantages of large active area and long adhesion time. The medicine can be used for treating colpitis mycotica, senility colpitis and uterine neck erosion.
Description
Technical field
The present invention relates to the processing technology technical field of Chinese patent medicine gel, relate in particular to and protect FUKANG gel and preparation method.
Background technology
Cervical erosion, vaginitis etc. are women's frequently-occurring disease, commonly encountered diseases, and the dosage form that external curing is commonly used has lotion, suppository, vaginal tablet, effervescent tablet, foam etc.From clinical practice, lotion is short action time; Suppository, tablet etc. are little with the mucosa contact area, and effervescent tablet has certain zest to mucosa, and using has sense of discomfort often; Foam is a kind of external preparation of vagina preferably, but need to add propellant, container is required high, cost of manufacture is big, and that gel has an active area is big, adheres to lasting, long-acting, efficient, quick-acting advantage of time, and has nonirritant, safe in utilization, simple for production, plurality of advantages such as cost is low are a kind of vagina external preparation that has promotional value.
Original dosage form of protecting the FUKANG gel is: BAOFUKANG SHUAN, guarantor's FUKANG foam.BAOFUKANG SHUAN is taken in " in 2000 editions one one of the Chinese pharmacopoeia, protect the new drug that the FUKANG foam is approval in 98 years, we change its agent into and protect the FUKANG gel, the performance plurality of advantages that gel had, the standard of improving the quality of products simultaneously, enable to satisfy and ensure better people's medication demand, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method of protecting the FUKANG gel and improve the quality of products and curative effect, increase the stability of product, enrich medicine variety, to satisfy and to ensure people's medication demand better.
The object of the present invention is achieved like this:
1, protecting FUKANG gel and preparation method comprises the steps:
1.1 protecting the prescription of FUKANG gel forms
Oleum Curcumae 25-250g Borneolum Syntheticum 25-250g
Right amount of auxiliary materials is made 5000ml altogether
Its optimum formula is:
Oleum Curcumae 82g Borneolum Syntheticum 75g
Right amount of auxiliary materials is made 5000ml altogether
1.2 protect FUKANG preparing gel technology
Get Oleum Curcumae, Borneolum Syntheticum and make gel with suitable technology, its system technology can adopt following technology, also can adopt other suitable technology.
Technology one is got Oleum Curcumae and proper amount of surfactant mixing, and Borneolum Syntheticum, slowly adds in the gel-type vehicle with above-mentioned oil solution mixing with an amount of ethanol/anhydrous alcohol solution, and the limit edged stirs, and regulates pH value, adds water to full dose, continue to stir, and packing, promptly.
Technology two is got Oleum Curcumae, Borneolum Syntheticum is made clathrate, after the suitable quantity of water dissolving, slowly adds in the gel-type vehicle, and the limit edged stirs, and regulates pH value, adds water to full dose, continue to stir, and packing, promptly.
1.3 be guarantor's FUKANG gel by the prepared gel of technology
Protect the FUKANG gel among the present invention and mainly contain acceptable gel adjuvant on Oleum Curcumae, Borneolum Syntheticum, one or more pharmaceuticss.
Used gel adjuvant comprises the acceptable adjuvant that is suitable for use in the preparation gel on all pharmaceuticss among the present invention, but one or more are used.One or more are used as carbomer, CMC-Na, HPMC, PVA, alginate, tragcanth or other suitable adjuvant.
The present invention protects in the FUKANG gel can add an amount of transdermal enhancer, but one or more be used, to strengthen the penetration capacity of medicine, improve curative effect.The general working concentration of azone is 0.1-10%, and typical concentrations is 0.5-2%.Except that azone, also can select other suitable transdermal enhancers for use, available a kind ofly also can multiplely be used.
The present invention protects in the FUKANG gel can add an amount of antiseptic, preferably selects the mould fungus inhibition effect that has concurrently for use, and be suitable in acid medium, existing, as sorbic acid, nipalgin or other suitable antiseptic.
The present invention protects in the FUKANG gel can add an amount of wetting agent, with the moisture in the better maintenance preparation, increases the comfort when using, and wetting agent can be selected glycerol, propylene glycol etc. for use, also can select other suitable wetting agent for use.
The present invention protects in the FUKANG gel can add an amount of antioxidant, to strengthen base stability.
The pH value that the present invention protects the FUKANG gel is 3.5-5.5, and optimal pH is that 4-5 makes at bactericidal antiphlogistic simultaneously, not only protects mucosa and vagina sour environment not to be damaged, and can strengthen self purification.
Oleum Curcumae and Borneolum Syntheticum can directly be used among the present invention, also can make clathrate earlier, and refabrication becomes gel, and the enclose material can be selected the cyclodextrin or derivatives thereof for use, also can select other suitable enclose material for use.
Contained principal agent Oleum Curcumae and Borneolum Syntheticum carried out the qualitative, quantitative inspection respectively in the FUKANG gel to protecting in the present invention.
The specific embodiment
Following embodiment can be for reference in order to further specify the present invention, but do not limit the scope of the invention thus.
Embodiment 1: get Oleum Curcumae and an amount of tween 80 mixing, Borneolum Syntheticum with an amount of dissolve with ethanol after, with above-mentioned oil solution mixing, standby; Other gets CMC-Na and glycerol is an amount of, adds water nature swelling, makes gel-type vehicle, and it is an amount of slowly to add above-mentioned reserve liquid and Azone, and the limit edged stirs to evenly, regulates pH value, adds water to full dose, continues to stir, and packing promptly.
Embodiment 2: get Oleum Curcumae and an amount of tween 80 mixing, Borneolum Syntheticum with an amount of dissolve with ethanol after, with above-mentioned oil solution mixing, standby; Get HPMC and add the suitable quantity of water swelling, make gel-type vehicle, slowly add above-mentioned reserve liquid, glycerol, dimethyl sulfoxide, the limit edged stirs, and regulates pH value, adds water to full dose, continues to stir, and packing promptly.
Embodiment 3: gets Oleum Curcumae and Borneolum Syntheticum and makes the hydroxy propyl-Beta cyclodextrin clathrate respectively, and standby with an amount of aquae destillata dissolving; Other gets CMC-Na and glycerol is an amount of, adds water nature swelling, makes gel-type vehicle, and it is an amount of slowly to add above-mentioned reserve liquid and Azone, and the limit edged stirs to evenly, regulates pH value, adds water to full dose, continues to stir, and packing promptly.
Claims (7)
1. protect FUKANG gel and preparation method thereof for one kind, it is characterized in that: Oleum Curcumae and proper amount of surfactant mixing, Borneolum Syntheticum is made clathrate with an amount of ethanol/anhydrous alcohol solution with oil solution mixing/Oleum Curcumae, Borneolum Syntheticum, with slowly adding gel-type vehicle, an amount of transdermal enhancer, an amount of antiseptic, wetting agent, antioxidant after the suitable quantity of water dissolving, the limit edged stirs, regulate pH value, add water to full dose, continue to stir, packing, promptly.
2. guarantor's FUKANG gel according to claim 1 and preparation method thereof is characterized in that: the gel adjuvant can adopt as carbomer, CMC-Na, HPMC, PVA, alginate, tragcanth a kind of/multiple being used.
3. guarantor's FUKANG gel according to claim 1 and preparation method thereof, it is characterized in that: can add an amount of transdermal enhancer azone, working concentration is 0.1-10%, and optium concentration is 0.5-2%, except that azone, the transdermal enhancer that also can select for use other to suit is a kind of also can multiplely to be used.
4. guarantor's FUKANG gel according to claim 1 and preparation method thereof is characterized in that: can add an amount of antiseptic in the gel, the best is selected the mould fungus inhibition effect that has concurrently for use, and the sorbic acid/nipalgin that is suitable for existing in acid medium.
5. guarantor's FUKANG gel according to claim 1 and preparation method thereof is characterized in that: can add an amount of wetting agent in the gel, with the moisture in the better maintenance preparation, increase the comfort when using, wetting agent the best is selected glycerin/propylene glycol for use.
6. guarantor's FUKANG gel according to claim 1 and preparation method thereof; it is characterized in that: the pH value of gel is 3.5-5.5; optimal pH is that 4-5 makes at bactericidal antiphlogistic simultaneously, not only protects mucosa and vagina sour environment not to be damaged, and can strengthen self purification.
7. guarantor's FUKANG gel according to claim 1 and preparation method thereof is characterized in that: contained principal agent Oleum Curcumae and Borneolum Syntheticum carried out the qualitative, quantitative inspection respectively in the FUKANG gel to protecting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03124593 CN1565492A (en) | 2003-06-22 | 2003-06-22 | Gynecopathy treating gelatin and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03124593 CN1565492A (en) | 2003-06-22 | 2003-06-22 | Gynecopathy treating gelatin and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1565492A true CN1565492A (en) | 2005-01-19 |
Family
ID=34469006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03124593 Pending CN1565492A (en) | 2003-06-22 | 2003-06-22 | Gynecopathy treating gelatin and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1565492A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535867A (en) * | 2016-02-15 | 2016-05-04 | 福建艾女人生物科技有限公司 | Antibacterial gel special for gynecology and preparation method thereof |
| CN107184911A (en) * | 2017-06-19 | 2017-09-22 | 太原谷歌医药科技有限公司 | One kind is used to prevent cervical carcinoma and treatment papillomavirus（HPV）Infection and the product and preparation method of colpitis |
-
2003
- 2003-06-22 CN CN 03124593 patent/CN1565492A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535867A (en) * | 2016-02-15 | 2016-05-04 | 福建艾女人生物科技有限公司 | Antibacterial gel special for gynecology and preparation method thereof |
| CN107184911A (en) * | 2017-06-19 | 2017-09-22 | 太原谷歌医药科技有限公司 | One kind is used to prevent cervical carcinoma and treatment papillomavirus（HPV）Infection and the product and preparation method of colpitis |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |