CN1562313A - effervesce tablet of rheum and ground beetle, and preparation method - Google Patents
effervesce tablet of rheum and ground beetle, and preparation method Download PDFInfo
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Abstract
An effervescent tablet 'Dahuang Zhechong' is prepared from 12 Chinese-medicinal materials including rhubarb, peach kernel, ground beetle, leech, etc through respectively extracting, mixing with additives and shaping.
Description
Affiliated technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of pieplant ground beetle effervescent tablet and preparation method thereof.
Background of invention
Da Huang female ground beetle ball derives from Han dynasty Zhang Zhongjing " Medical Treasures of the Golden Chamber " side, mainly form by Radix Et Rhizoma Rhei, Semen Persicae, Semen Armeniacae Amarum, Hirudo, Tabanus, Holotrichia diomphalia Bates, Resina Toxicodendri, the Radix Paeoniae Alba, Radix Scutellariae, Radix Rehmanniae, Radix Glycyrrhizae, Eupolyphaga Seu Steleophaga 12 flavor Chinese medicines, have the effects such as yin fluid astringing, easing the affected liver to relieve pain, YIN nourishing removing heat from blood, eliminating fire and detoxication, invigorating the spleen and replenishing QI, the spleen strengthening and damp drying that disappear, nourish blood of removing blood stasis, eliminating stagnation, for irritability due to the chronic hepatitis of poisoning intrusion obstinate disease, the liver cirrhosis smoulder, that qi depression to blood stasis, malicious heresy are reluctant to leave, the stasis of blood is given birth to many symptoms that heat causes for a long time is effective.The patient has the whole body relaxation after taking Da Huang female ground beetle ball, shows as free movement of the bowels, and abdominal distention disappears, and appetite increases, and sleep takes a turn for the better, and after 2～3 months, various blood stasis symptoms, sign also have alleviation in various degree; Liver function is improved obviously; Part patient's liver and spleen retraction, liver palm, spider angioma and the body of the tongue stasis of blood are dark, die Blausucht alleviates.For obstruction of collaterals by blood stasis is that main symptom is mingled with other pattern of syndrome such as dampness-heat in the liver and gallbladder, stagnation of liver-QI with deficiency of the spleen, has ALT, TB rising person should select Herba Sedi, Radix Sophorae Tonkinensis preparation for use, or medication combined treatment such as Herba Sidae Rhombifoliae granule.
The ultimate principle of ultrasound assisted extraction technique mainly is that the leaching that utilizes cavitation effect of ultrasonic waves to quicken effective ingredients in plant is extracted, hyperacoustic in addition second order effect, as mechanical vibration, emulsifying, spread, smash, chemical effect etc., also can quicken desire and extract diffusion release and abundant and the solvent of composition, be beneficial to extraction.Compare with conventional extraction method, the supersound extraction time is short, yield is high, need not heating.Use the supersound extraction effective ingredient in Chinese, simplified operation sequence greatly, shortened extraction time, improved product yield and purity, improved not only loaded down with trivial details time-consuming but also easy emulsive extracting method commonly used; With the ultrasonic Radix Et Rhizoma Rhei anthraquinone constituents that extracts from Radix Et Rhizoma Rhei of different frequency, with conventional decocting method extract phase ratio, ultrasonic need not heated, and the yield difference is the highest with the Radix Et Rhizoma Rhei anthraquinone constituents yield after the 20KHz frequency supersound extraction especially with the supersonic frequency difference; And ultrasound wave does not have influence to the composition of extractum.Ultrasound assisted extraction technique can be avoided the destruction of High Temperature High Pressure to effective ingredient, and wide application prospect is arranged.
The Pharmacopoeia of the People's Republic of China (version in 2000, one one) 358 pages of quality standard and process recipes that write down Da Huang female ground beetle ball, this technology is that 12 flavor Chinese medicines in the prescription are pulverized, add refined honey and be prepared into water-honeyed pill or big honeyed pills, Chinese medicine is handled without any extraction among all sides, though reservation Effective Components of Chinese Herb, but also kept a large amount of invalid even poisonous impurity, not only increased patient's dose, and the internal organs of the body that makes the patient is born decomposition or is drained invalid, toxic component, increase patient's burden; Number of patent application be 02152053 " a kind of Radix Et Rhizoma Rhei worm ball " patent disclosure the process recipes of Radix Et Rhizoma Rhei worm ball, officinal process recipes that the present invention has been repetition only is without any novelty.
The advantage of the existing granule of effervescent tablet has the characteristics of tablet again, be to be a kind of tablet that disintegrating agent is made with the effervescent material, in water, can produce a large amount of bubbles, and can dissolve in the short period of time, have that drug effect is rapid, bioavailability is high, convenient carrying, the patient who is specially adapted to child, old man and can not swallows solid preparation, so effervescent tablet has the dosage form novelty, the characteristics that market prospect is wide.
Summary of the invention
For these reasons, the Radix Et Rhizoma Rhei effective site that the present invention adopts supercritical ultrasonics technology and water extraction to extract, extract Semen Persicae with the hot water extraction method, Semen Armeniacae Amarum, Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga, Radix Rehmanniae, Holotrichia diomphalia Bates, the effective site of Tabanus, extract Hirudo with ethanol extraction method, Resina Toxicodendri, make up with pharmaceutic adjuvant, be prepared into effervescent formulation, this preparation technology reduces patient's dose greatly, the effective ingredient of taking increases, invalid, deleterious composition reduces greatly, thereby increase the safety of medicine, adverse reaction reduction improves the pharmacological effect of Da Huang female ground beetle effervescent tablet.
One. process recipes
(1) prescription of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g,, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) Da Huang female ground beetle effervescent tablet raw material consists of: Radix Et Rhizoma Rhei effective site is the 30-60 weight portion, Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, stir-fry) mixed extraction effective site is the 95-190 weight portion, the effective site that Resina Toxicodendri (forging), Hirudo are extracted is the 9-18 weight portion, and pharmaceutic adjuvant is the 2732-2866 weight portion;
(3) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is ethanol extraction 8-12 minute of 75%-85% with concentration, and extracting liquid filtering, filtrate recycling ethanol are to the greatest extent, and concentrate drying is pulverized standby; Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with the 8-12 of medical material amount doubly, temperature is 70 ℃-85 ℃ hot water, extract 2-4 time, extraction time is 1.5-3 hour, and extracting solution merges, and filters, concentrate, drying and crushing is standby; Get Resina Toxicodendri (forging), Hirudo, pulverize, spend the night with the 70%-90% soak with ethanol, 40 ℃-70 ℃ of control temperature were extracted 1-3 hour, extracted 2-4 time, and merge extractive liquid, reclaims ethanol to the greatest extent, obtains extractum, and drying is pulverized; Get the extraction drug effective region and mix with pharmaceutic adjuvant (alkali source being wrapped up with Polyethylene Glycol), granulation, drying, granulate, tabletting, check, packing obtain Da Huang female ground beetle effervescent tablet.
Two. pharmacology embodiment
Embodiment 1
The acute toxicological experiment of Da Huang female ground beetle effervescent tablet
Experiment medicine: Da Huang female ground beetle effervescent tablet of the present invention (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides)
Laboratory animal: healthy mice 18-22g.
Experimental technique: it is 12.0g/60kg that Da Huang female ground beetle effervescent tablet of the present invention is recommended the clinical consumption per day of adult, amounts to crude drug amount 66.7g/60kg.Carry out maximum dosage-feeding test, i.e. tolerant this medicament extract Cmax of animal, maximum volume 62.5%, 0.5ml/10g.Irritate stomach and give in the mice one day three times, amount to crude drug amount 173.3g/kg, be equivalent to 156 times of clinical adult's dosage, to observe the acute toxic reaction of mice.The result shows: it is dead to irritate none example of stomach mice, its activity, breathe, ingest, drinking-water, fur and kill the perusal of internal organs such as the inspection back heart, liver, spleen, lung, kidney, adrenal gland, thymus, there is no unusual.Because maximum dosage-feeding is tested none routine animal dead, does not also see other acute toxic reactions, therefore can not measure LD
50Show that Da Huang female ground beetle effervescent tablet acute toxicity of the present invention is less.
Embodiment 2
Da Huang female ground beetle effervescent tablet is to CCl
4Hepatic injury and HBV antigenic action
Laboratory animal Balb/C is a mice, body weight 20-22g, and the male and female dual-purpose is provided by Peking University's Experimental Animal Center.
Experiment medicine: the big Acridid Zhe of the present invention effervescent tablet (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides)
Da Huang female ground beetle ball (buy, and Shanghai Leiyun Pharmaceutical Industry Co., Ltd. gives birth to by the big pharmacy of Xidan, Beijing Golden Elephant
Produce)
Bifendate drop pill (buy, and the Beijing XieHe medicine Factory produces by the big pharmacy of Xidan, Beijing Golden Elephant.)
Reagent: (the enzyme immunosorbent adsorption test ELISA), is provided by the biochemical reagents experiment of Shanghai section China the HBV markers diagnostic reagent.
Instrument: Hitachi's 7170 type automatic biochemistry analyzers, reagent is provided by Hitachi, Ltd.
Statistical method: date processing adopts the t check relatively of two sample means, and calculates under Pems statistics software kit.
Experimental technique: mice is divided into normal control, CCl at random
4, bifendate (200mg/kg), Da Huang female ground beetle ball, Da Huang female ground beetle effervescent tablet of the present invention, normal control group and CCl
4Group gives normal saline.Animal is irritated stomach (i.g) administration 1 time, continuous 4 days every day.In administration the 3rd day except that the normal control group, every group of equal lumbar injection (i.p) CCl
4(20ul/kg), hematometry serum glutamic pyruvic transminase (ALT) and glutamic oxaloacetic transaminase, GOT (AST) after 16 hours, and hepatic tissue is made the conventional organization pathological examination.The result shows, injection CCl
4After 16 hours, hepatic tissue and liver function are obviously impaired, and Serum ALT and AST significantly raise, and Da Huang female ground beetle effervescent tablet of the present invention has the effect of significant protection liver, can reduce Serum ALT and AST level.(seeing Table 1), the variation and the necrosis that alleviate hepatic tissue see Table 1:
Table 1 couple CCl
4The influence of hepatic injury ATL and AST (X ± S, U/L)
| Group | Number of animals | Dosage (g/kg) | ?ALT | ?AST |
| The normal control group | 10 | ?84.4±32.5② | ?111.7±70.4② | |
| CCl 4 | 15 | ?1669.4±953.9 | ?533.0±239.8 | |
| Da Huang female ground beetle ball | 15 | ?20 | ?1002.1±491.7① | ?352.4±186.9① |
| Da Huang female ground beetle effervescent tablet | 15 | ?20 | ?958.2±487.6 ?② | ?304.5±93.7② |
| Bifendate | 15 | ?0.2 | ?934.6±613.5 ?② | ?279.0±95.8② |
Annotate: with CCl
4Group is 2. P＜0.01, P＜0.05 more 1.
Conclusion: show Da Huang female ground beetle effervescent tablet of the present invention and Radix Et Rhizoma Rhei worm ball relatively by above pharmacological evaluation, have better pharmacological action, show that by acute toxicological experiment Da Huang female ground beetle effervescent tablet of the present invention has good safety.
Three. check and analysis
High effective liquid chromatography for measuring total Radix Et Rhizoma Rhei anthraquinone (in emodin) content
Instrument and reagent: high performance liquid chromatograph (day island proper Tianjin), CR-3A data processor, CTO-6A column oven, SpherisorbC18 post (Dalian is according to Lyntech Corporation (US) 10177 South 77th East Avenue Tulsa, Oklahoma 74133 U.S. for 4.6mm * 300mm, 5 μ m).The emodin reference substance is available from Chinese medicine and biological products assay institute; Da Huang female ground beetle effervescent tablet of the present invention (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides), Da Huang female ground beetle ball (Golden Elephant big pharmacy in Xidan, Beijing is bought, and Shanghai Leiyun Pharmaceutical Industry Co., Ltd. produces); Acetonitrile is a chromatographically pure, and all the other reagent are analytical pure.
Method and result: chromatographic condition mobile phase is acetonitrile-0.1% phosphoric acid (90: 10); Flow velocity 0.6ml/min detects wavelength 254nm, chart speed 1mm/min, sensitivity 0.04AUFS; 45 ℃ of column temperatures.The drafting precision of standard curve takes by weighing emodin reference substance 5～10mg, puts in the 50ml measuring bottle, adds the chloroform dissolving, makes 0.2 respectively, 0.18, the solution of 0.12mg/ml, the accurate respectively 1ml that draws, put in the same 10ml measuring bottle, add chloroform and be diluted to scale, in contrast product liquid.Accurate reference substance liquid 4,6,8,10,12 μ 1 that draw inject chromatograph of liquid respectively, and the record peak area is an abscissa with the peak area, and sample size (μ g) is a vertical coordinate, the drawing standard curve.Through date processing, regression equation is respectively: emodin: Y1=(3.13+0.16X) * 10-4 range of linearity is: emodin 0.08～0.24 μ g.The mensuration of sample: two kinds of preparations are ground into fine powder, get 0.1g, the accurate title, decide, and puts in the apparatus,Soxhlet's, add the chloroform soaked overnight, extract 8h, extracting solution washs with 0.5% sodium hydrate aqueous solution 100ml gradation, and is colourless to cleaning mixture, and be incorporated in the 100ml measuring bottle, fixed molten, as test sample liquid.Accurate reference substance liquid 4～10 μ l that draw, test sample liquid 10 μ l inject chromatograph of liquid respectively, calculate content with the external standard two-point method, the results are shown in Table 2:
The content of two kinds of preparations of table 2 relatively
| Group | Total Radix Et Rhizoma Rhei anthraquinone (in emodin) content (mg/g) |
| Da Huang female ground beetle ball | ??????????1.27 |
| Da Huang female ground beetle effervescent tablet of the present invention | ??????????1.68 |
Conclusion: relatively, the content of the total Radix Et Rhizoma Rhei anthraquinone of monarch drug Radix Et Rhizoma Rhei (in emodin) improves in the Da Huang female ground beetle effervescent tablet Da Huang female ground beetle ball of the present invention, proves absolutely preparation technology's of the present invention practical significance.
Four. preparation embodiment
Embodiment 1
(1) prescription of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g,, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is 75% ethanol extraction 8 minutes with concentration, and extracting liquid filtering, filtrate recycling ethanol are to the greatest extent, and concentrate drying is pulverized standby; Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with 8 times of the medical material amount, temperature 70 ℃ hot water, extract 2 times, extraction time is 1.5 hours, and extracting solution merges, and filters, concentrate, drying and crushing is standby; Get Resina Toxicodendri (forging), Hirudo, pulverize, spend the night with 70% soak with ethanol, 40 ℃ of control temperature were extracted 1 hour, extracted 2 times, and merge extractive liquid, reclaims ethanol to the greatest extent, obtains extractum, and drying is pulverized; Get extraction drug effective region 134 grams and totally 2866 restrain mix homogeneously with pharmaceutic adjuvant citric acid, protein sugar, sodium bicarbonate (wrapping up), fragrant citrus essence with Polyethylene Glycol, granulation, drying, granulate, tabletting, check, packing obtain 1000 of Da Huang female ground beetle effervescent tablets.
Embodiment 2
(1) prescription of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g,, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is 85% ethanol extraction 12 minutes with concentration, carries connection liquid and filters, and filtrate recycling ethanol is to the greatest extent, and concentrate drying is pulverized standby; Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with 12 times of the medical material amount, temperature 85 ℃ hot water, extract 4 times, extraction time is 3 hours, and extracting solution merges, and filters, concentrate, drying and crushing is standby; Get Resina Toxicodendri (forging), Hirudo, pulverize, spend the night with 90% soak with ethanol, 70 ℃ of control temperature were extracted 3 hours, extracted 4 times merge extractive liquid,, reclaimed ethanol to the greatest extent, obtained extractum, and drying is pulverized; Get and extract drug effective region 268 grams and pharmaceutic adjuvant tartaric acid, sweetleaf centautin, potassium bicarbonate (wrapping up), Fructus Citri Limoniae essence and totally 2732 restrain and mix with Polyethylene Glycol, granulation, drying, granulate, tabletting, check, packing obtain 1000 of Da Huang female ground beetle effervescent tablets.
Embodiment 3
(1) prescription of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g,, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is 80% ethanol extraction 9 minutes with concentration, and extracting liquid filtering, filtrate recycling ethanol are to the greatest extent, and concentrate drying is pulverized standby; Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with 10 times of the medical material amount, temperature 75 ℃ hot water, extract 3 times, extraction time is 2 hours, and extracting solution merges, and filters, concentrate, drying and crushing is standby; Get Resina Toxicodendri (forging), Hirudo, pulverize, spend the night with 75% soak with ethanol, 50 ℃ of control temperature were extracted 1.5 hours, extracted 3 times, and merge extractive liquid, reclaims ethanol to the greatest extent, obtains extractum, and drying is pulverized; Getting the mixture (wrapping up with Polyethylene Glycol) that extracts drug effective region 172 grams and pharmaceutic adjuvant sodium bicarbonate and potassium bicarbonate, citric acid, tartaric acid mixture, lactose, strawberry essence totally 2828 restrains and mixes, granulation, drying, granulate, tabletting, check, packing obtain 1000 of Da Huang female ground beetle effervescent tablets.
Embodiment 4
(1) prescription of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g,, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is 80% ethanol extraction 10 minutes with concentration, and extracting liquid filtering, filtrate recycling ethanol are to the greatest extent, and concentrate drying is pulverized standby; Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with 10 times of the medical material amount, temperature 80 ℃ hot water, extract 3 times, extraction time is 2.5 hours, and extracting solution merges, and filters, concentrate, drying and crushing is standby; Get Resina Toxicodendri (forging), Hirudo, pulverize, spend the night with 85% soak with ethanol, 55 ℃ of control temperature were extracted 2 hours, extracted 3 times, and merge extractive liquid, reclaims ethanol to the greatest extent, obtains extractum, and drying is pulverized; Get and extract drug effective region 195 grams and pharmaceutic adjuvant potassium bicarbonate (wrapping up), citric acid tartaric acid mixture, sweetleaf centautin milk-sugar mixture, apple essence and totally 2805 restrain and mix with Polyethylene Glycol, granulation, drying, granulate, tabletting, check, packing obtain 1000 of Da Huang female ground beetle effervescent tablets.
Embodiment 5
(1) prescription of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g,, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is 80% ethanol extraction 11 minutes with concentration, and extracting liquid filtering, filtrate recycling ethanol are to the greatest extent, and concentrate drying is pulverized standby; Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with 11 times of the medical material amount, temperature 80 ℃ hot water, extract 3 times, extraction time is 2.5 hours, and extracting solution merges, and filters, concentrate, drying and crushing is standby; Get Resina Toxicodendri (forging) Hirudo, pulverize, spend the night with 85% soak with ethanol, 65 ℃ of control temperature were extracted 2 hours, extracted 4 times, and merge extractive liquid, reclaims ethanol to the greatest extent, obtains extractum, and drying is pulverized; Get and extract drug effective region 246 grams and pharmaceutic adjuvant sodium bicarbonate (wrapping up), citric acid, protein sugar sweetleaf centautin mixture, apple essence and totally 2754 restrain and mix with Polyethylene Glycol, granulation, drying, granulate, tabletting, check, packing obtain 1000 of Da Huang female ground beetle effervescent tablets.
Embodiment 6
(1) prescription of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g,, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is 85% ethanol extraction 8 minutes with concentration, and extracting liquid filtering, filtrate recycling ethanol are to the greatest extent, and concentrate drying is pulverized standby; Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with 12 times of the medical material amount, temperature 70 ℃ hot water, extract 4 times, extraction time is 1.5 hours, and extracting solution merges, and filters, concentrate, drying and crushing is standby; Get Resina Toxicodendri (forging), Hirudo, pulverize, spend the night with 80% soak with ethanol, 65 ℃ of control temperature were extracted 3 hours, extracted 3 times, and merge extractive liquid, reclaims ethanol to the greatest extent, obtains extractum, and drying is pulverized; Get and extract drug effective region 255 grams and pharmaceutic adjuvant sodium bicarbonate and potassium bicarbonate mixture (wrapping up), citric acid, protein sugar and milk-sugar mixture, Fructus Citri Limoniae essence and totally 2745 restrain and mix with Polyethylene Glycol, granulation, drying, granulate, tabletting, check, packing obtain 1000 of Da Huang female ground beetle effervescent tablets.
Claims (8)
1. pieplant ground beetle effervescent tablet is characterized in that it is a effective site by 12 flavor Chinese medicine extraction such as Radix Et Rhizoma Rhei, with the pharmaceutic adjuvant combination, is prepared into effervescent formulation; Its feature is that also Da Huang female ground beetle effervescent tablet raw material consists of: Radix Et Rhizoma Rhei effective site is the 30-60 weight portion, Radix Et Rhizoma Rhei extracts residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, stir-fry) mixed extraction effective site is the 95-190 weight portion, the effective site that Resina Toxicodendri (forging), Hirudo are extracted is the 9-18 weight portion, and the pharmaceutic adjuvant adjuvant is the 1206-2412 weight portion;
2. the preparation method of a kind of Da Huang female ground beetle effervescent tablet according to claim 1, its feature may further comprise the steps:
(1) medical material of Da Huang female ground beetle effervescent tablet consists of:
Radix Et Rhizoma Rhei 300g, Eupolyphaga Seu Steleophaga (stir-fry) 30g, Hirudo (system) 60g, Radix Paeoniae Alba 120g,
Holotrichia diomphalia Bates (stir-fry) 45g, Resina Toxicodendri (forging) 30g, Semen Persicae 120g, Semen Armeniacae Amarum (stir-fry) 120g,
Radix Scutellariae 60g, Radix Rehmanniae 300g, Tabanus (remove the wing foot, fry) 45g, Radix Glycyrrhizae 90g.
(2) getting the Radix Et Rhizoma Rhei decoction pieces, put into the supersound extraction jar, is ethanol extraction 8-12 minute of 75%-85% with concentration, and extracting liquid filtering, filtrate recycling ethanol are to the greatest extent, and concentrate drying is pulverized, and obtains effective site;
(3) Radix Et Rhizoma Rhei extraction residual medicine dreg and Semen Persicae, Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Scutellariae, the Radix Paeoniae Alba, Eupolyphaga Seu Steleophaga (stir-fry), Radix Rehmanniae, Holotrichia diomphalia Bates (stir-fry), Tabanus (remove the wing foot, fry) mix, with the 8-12 of medical material amount doubly, temperature is 70 ℃-85 ℃ hot water, extract 2-4 time, extraction time is 1.5-3 hour, and extracting solution merges, filter, concentrate, drying and crushing obtains effective site;
(4) get Resina Toxicodendri (forging), Hirudo, pulverize, spend the night with the 70%-90% soak with ethanol, 40 ℃-70 ℃ of control temperature were extracted 1-3 hour, extracted 2-4 time, and merge extractive liquid, reclaims ethanol to the greatest extent, obtains extractum, and drying is pulverized, and obtains effective site;
(5) get the extraction drug effective region and mix with pharmaceutic adjuvant, granulation, drying, granulate, tabletting, check, packing obtain Da Huang female ground beetle effervescent tablet.
3. the pharmaceutic adjuvant according to claim 1,2 described Da Huang female ground beetle effervescent tablets is effervescent, sweeting agent and correctives.
4. Da Huang female ground beetle effervescent tablet according to claim 3 is characterized in that described correctives is any in fragrant citrus essence, Fructus Citri Limoniae essence, strawberry essence and the apple essence.
5. Da Huang female ground beetle effervescent tablet according to claim 3 is characterized in that described sweeting agent can be one or more the mixing sweet taste machine agent in protein sugar, sweetleaf centautin, the lactose.
6. Da Huang female ground beetle effervescent tablet according to claim 3 is characterized in that described effervescent is the mixture of organic acid and sodium bicarbonate and/or potassium bicarbonate.
7. according to the described organic acid of claim 6 mixture of a kind of in citric acid, the tartaric acid or two kinds.
The mixture of 8 sodium bicarbonate according to claim 6 and/or potassium bicarbonate wraps up with Polyethylene Glycol.
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| CN 200410031124 CN1562313A (en) | 2004-04-12 | 2004-04-12 | effervesce tablet of rheum and ground beetle, and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100435840C (en) * | 2006-11-30 | 2008-11-26 | 灵宝市商业医院 | Medicament for treating hyperplasia of prostate |
| CN102697953A (en) * | 2012-06-15 | 2012-10-03 | 李承平 | Tablet for activating blood to eliminate diseases |
| CN104107213A (en) * | 2013-04-16 | 2014-10-22 | 江西普正制药有限公司 | Preparation method of Tibetan medicine Lamiophlomis rotata effervescent tablet |
| CN104473185A (en) * | 2014-12-27 | 2015-04-01 | 广西壮族自治区海洋研究所 | Effervescent tablet containing vitamin C and sipunculusnudus enzymatic protein |
| CN112402515A (en) * | 2020-12-07 | 2021-02-26 | 江苏颐海药业有限责任公司 | Chinese medicinal extract containing insect medicine and preparation method of preparation thereof |
-
2004
- 2004-04-12 CN CN 200410031124 patent/CN1562313A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100435840C (en) * | 2006-11-30 | 2008-11-26 | 灵宝市商业医院 | Medicament for treating hyperplasia of prostate |
| CN102697953A (en) * | 2012-06-15 | 2012-10-03 | 李承平 | Tablet for activating blood to eliminate diseases |
| CN104107213A (en) * | 2013-04-16 | 2014-10-22 | 江西普正制药有限公司 | Preparation method of Tibetan medicine Lamiophlomis rotata effervescent tablet |
| CN104107213B (en) * | 2013-04-16 | 2019-01-11 | 江西普正制药有限公司 | The preparation method of Tibet medicine lamivphlomis root effervescent tablet |
| CN104473185A (en) * | 2014-12-27 | 2015-04-01 | 广西壮族自治区海洋研究所 | Effervescent tablet containing vitamin C and sipunculusnudus enzymatic protein |
| CN112402515A (en) * | 2020-12-07 | 2021-02-26 | 江苏颐海药业有限责任公司 | Chinese medicinal extract containing insect medicine and preparation method of preparation thereof |
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