CN1562224A - Medication for treating painful symptoms of the illness - Google Patents

Abstract

An antalgic Chinese medicine for treating the pain caused by operation, bone fracture, injury, etc is prepared from willmott ceratostigma root. Its preparing process is also disclosed.

Description

The medicine and the preparation technology thereof of treatment antalgesic

Technical field:

The present invention relates to the medicine and the preparation technology thereof of the treatment antalgesic that the single flavor Chinese herbal medicine of a kind of usefulness makes.

Technical background:

Growing blood stasis, meridians resistance by gas, to grow all kinds of antalgesics such as extremely postoperative pain of institute, traumatic pain be common disease, and the medicine for the treatment of generally has plaster at present, and oral agents is also arranged.But great majority all are the compound recipe dosage forms, and are also rare with the medicine of single prescription, and exist the pain relief persistent period short, problems such as price height.

Summary of the invention:

The objective of the invention is to: provide a kind of usefulness preparation that single herbal medicine is made with and preparation technology, its good effect, low price is to satisfy the needs of extensive patients.

The present invention is achieved in that it is the preparation made from Radix ceratostigmatis willemottiani list Herba indigoferae Pseudotinctoriae.

Described preparation is tablet, capsule, granule.

Its preparation technology is: to produce 1000 (sheets), get Radix ceratostigmatis willemottiani 300g～800g, decoct with water secondary, each 2 hours, collect distillate, cold preservation is more than 48 hours, the collection crystallization is deposited standby in addition, and collecting decoction filters, it is 1.33 that filtrate is concentrated into relative density, puts the crystal that cold back adds above-mentioned collection, stirs evenly, add an amount of adjuvant, mixing is made granule, drying, coating are promptly.

Radix ceratostigmatis willemottiani is warm in nature, sweet in the mouth.Has promoting blood circulation and stopping pain, the effect of blood stasis dispersing and fresh blood promoting.

Advantages such as the present invention compared with prior art has the alleviating pain longer duration, and price is low, has no side effect, and technology is simple.Can treat diseases such as postoperative pain, traumatic pain.Concrete clinical summary is as follows:

One, research method

(1), case is selected

1. tcm diagnosis standard

Acute periankle injury: different forms of violence causes the damage of ankle muscle, comprises fascia, tendon, ligament, and tissue such as subcutaneous tissue, part muscle, arthritis.

Acute trauma history is arranged: ankle soft tissue swelling, pain, ecchymosis, dysfunction; The X ray examination does not have fracture.

2. differential diagnosis in tcm standard

Qi stagnation and blood stasis type: acute trauma history is arranged, ankle swelling, ecchymosis or local pyrexia, pain with tenderness, localized pain, function limitation, pale tongue or dark partially, thin fur is white or yellow, the puckery or summary number of arteries and veins or string.

3. Western medicine diagnose standard

Acute soft tissue injury of ankles: comprise contusion (directly external force is hit or collided the limbs part, causes subcutaneous tissue of ankle, muscle, tendon equivalent damage) and sprain that (indirect violence makes limbs and periarticular fascia, muscle.Ligament hyperflexion, tractive cause the damage of surrounding soft tissue or tear).

4. include the case standard in

(1) the acute soft tissue injury course of disease is no more than 3 days;

(2) meet Western medicine diagnose standard and differential diagnosis in tcm standard person;

(3) age is at 18-65 between year.

5. get rid of case standard (comprising incompatibility or rejecting standard)

(1) above-mentioned symptom person due to the non-acute soft tissue injury of ankles;

(2) took relevant analgesic drug product person after the wound;

(3) age under-18s or over-65s person;

(4) gestation or women breast-feeding their children are to this medicine allergy sufferers;

(5) intentionally, important organ severe dysfunction persons such as liver, kidney;

(6) do not meet the standard of including in, non-curative effect reason, also non-untoward reaction and drug withdrawal person midway, and not medication in accordance with regulations can't judge that curative effect or data are incomplete, affect the treatment or safety judgement person.

(2), the administrated method and the course of treatment

The Radix ceratostigmatis willemottiani sheet, every day three times, each 2.Three days is a course of treatment.

Reach treatment back pain intensity, pain degree, tenderness, swelling and dysfunction respectively before the record treatment.

(3), observation index

1, pain intensity, (PI)

Help to judge by the patient or the doctor, oneself records with 0-10 numeral pain intensity staging.The no pain of 0 expression, 10 represent that patients think serious pain, and 1-3 mild pain, 4-6 are moderate pain, and 7-9 is a severe pain.

0 1 2 3 4 5 6 7 8 9 10

2. pain degree classification (WTO three step analgesia therapy pain grade scales)

0 grade of (0 minute) no pain;

I level (1 minute): (mild pain) though pain is arranged but still can stand, and can orthobiosis, sleep is interference-free;

II level (2 minutes): (moderate pain) pain is obvious, is impatient at, and needs to use analgesic, and sleep is disturbed;

III level (3 minutes): (severe pain) sharp ache, sleep seriously is interfered, and needs to use analgesic, can be with autonomic nervous dysfunction or positive position.

3. tenderness

No tenderness 0 minute

Mild pain when pushing, no pain expression 1 minute

Pain is heavier when pushing, and painful expression is arranged, and still can stand 2 fens

Sharp ache during flicking, tenderness 3 minutes

4. swelling

No swelling 0 minute

Mild swelling was lower than bone mark 1 minute

Moderate swelling, flat bone mark, dermatoglyph disappeared 2 fens

Severe swelling exceeds bone mark, and severe patient can have blister 3 minutes

5. joint motion

Can do comings and goings 0 minute

Moderate is limited, can take care of oneself, and can be engaged in 1 minute orthobiosis

Obviously limited, can take care of oneself, but can not be engaged in normal activity 2 minutes

The mobility forfeiture be can't take care of oneself 3 fens

(4), efficacy assessment standard

1. pain intensity poor (PID)

Be before the patient treatment and the difference of treatment back pain intensity, reaction pain relief degree.

2. total effects

Recovery from illness: pain, tenderness, swelling disappear, and joint motion is normal, and integration is 0 minute.

Produce effects: pain, tenderness, swelling obviously alleviate, and joint motion is normal substantially, and integration reduces more than 2/3.

Effectively: pain, tenderness, swelling alleviate to some extent, and joint motion recovers to some extent, and integration reduces more than 1/3.

Invalid: pain, tenderness, swelling, joint motion do not change, and integration reduces below 1/3.

3. safety is observed

There is the gastrointestinal side effect of case in observation post, whether has the secondary work of poison to understand medicine.

Two, clinical data

This is organized 30 routine cases and is outpatient service or emergency case.Male's 18 examples wherein, women's 12 examples, men and women's ratio is 1.5: 1.Minimum 18 years old of age, maximum 60 years old, average 33.88 ± 13.48 years old

Pain degree distributes

N I level (%) II level (%) III level (%)

30 7(23.33％) 21(70％) 2(6.67％)

Three, therapeutic outcome

(1) total effects

N recovery from illness produce effects enabledisable total effective rate

30 2 2 21 5 83.33％

This is organized in the 30 routine cases, 2 examples of fully recovering, produce effects 2 examples, effective 21 examples, invalid 5 examples. total effective rate 83.33%.

(2), each symptom and sign curative effect

The pain degree tenderness joint motion that swells and ache

Treat preceding 1.83 ± 0.53 1.87 ± 0.52 1.20 ± 0.48 1.27 ± 0.45

Treatment back 0.77 ± 0.43 1.06 ± 0.45 0.73 ± 0.64 0.76 ± 0.57

Relatively, expression is through the t check before and after the treatment, and there is significant difference p＜0.05.Treat the back and control preceding comparison, pain degree, tenderness, swelling, joint motion all have alleviation.

(3) pain intensity compares before and after the treatment

Pain intensity was poor before and after pain intensity treatment back pain intensity was treated before the treatment

4.55±1.11 1.43±1.14 3.00±1.05

Relatively, expression is through the t check before and after patient's statement treatment, and there is significant difference p＜0.05.The treatment back is relatively preceding with treatment, and pain intensity alleviates.

(4) relation of pain degree and curative effect

Pain degree n recovery from illness produce effects enabledisable is effective

Rate

I 7 1 0 5 1 85.71％

II 21 1 2 15 4 85.71％

III 2 0 2 0 0 100％

Through X ²P＞0.05, no difference of science of statistics are compared in check between three groups.Show that pain degrees at different levels and curative effect do not have dependency.

(5) safety is observed

In the 30 routine cases, finding no bad of tangible gastrointestinal tract should.

Four, discuss

The present invention is used for the treatment of acute ankle sprain 30 examples, 2 examples of fully recovering, produce effects 2 examples, effective 21 examples, invalid 5 examples, total effective rate 83.23%.Symptoms such as the pain that acute ankle sprain is caused, swelling, joint function disturbance are analyzed by statistics, and relatively, there is significant difference P＜0.05 before treatment back and the treatment, and treatment back symptom alleviates before the treatment.Pain degree and curative effect do not have dependency, and pain at different levels are all had tangible analgesic effect.Find no tangible gastrointestinal side effect in the therapeutic process.

The specific embodiment:

Embodiments of the invention: to produce 1000 tablets of tablets, get Radix ceratostigmatis willemottiani 500g, decoct with water secondary, each 2 hours, collect distillate, cold preservation was collected crystallization and is deposited standby in addition more than 48 hour; Collecting decoction filters, and it is 1.33 (70 ℃) that filtrate is concentrated into relative density, puts the crystal that cold back adds above-mentioned collection, stirs evenly, and adds an amount of additive of tablet, and mixing is made granule, and drying is pressed into 1000, and the bag film-coat promptly.

The present invention also can make capsule, granule etc. according to common process.

Claims (3)

1, a kind of medicine for the treatment of antalgesic is characterized in that: it is the preparation made from Radix ceratostigmatis willemottiani list Herba indigoferae Pseudotinctoriae.

2, the medicine of treatment antalgesic according to claim 1 is characterized in that: described preparation is tablet, capsule, granule.

3, the preparation technology of the medicine of a kind of claim 1,2 described treatment antalgesics is characterized in that: to produce 1000 (sheets), get Radix ceratostigmatis willemottiani 300g～800g, decoct with water secondary, each 2 hours, collect distillate, cold preservation is more than 48 hours, and the collection crystallization is deposited standby in addition, collecting decoction, filter, it is 1.33 that filtrate is concentrated into relative density, puts the crystal that cold back adds above-mentioned collection, stir evenly, add an amount of adjuvant, mixing, make granule, drying, coating is promptly.